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https://www.readbyqxmd.com/read/29668112/pharmacogenetic-manipulation-of-the-nucleus-accumbens-alters-binge-like-alcohol-drinking-in-mice
#1
Kush Purohit, Puja K Parekh, Joseph Kern, Ryan W Logan, Zheng Liu, Yanhua Huang, Colleen A McClung, John C Crabbe, Angela R Ozburn
BACKGROUND: Chronic alcohol intake leads to long-lasting changes in reward- and stress-related neuronal circuitry. The nucleus accumbens (NAc) is an integral component of this circuitry. Here, we investigate the effects of DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) on neuronal activity in the NAc and binge-like drinking. METHODS: C57BL/6J mice were stereotaxically injected with AAV2 hSyn-HA hM3Dq, -hM4Di, or -eGFP bilaterally into NAc [core + shell, core or shell]...
April 18, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29667811/in-vitro-and-in-vivo-studies-of-the-electrophilicity-of-physcion-and-its-oxidative-metabolites
#2
Xiaotong Qin, Ying Peng, Jiang Zheng
Physcion (1,8-dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione) is a bioactive component found in Polygoni Multiflori Radix (PMR) which has been widely used as traditional Chinese medicine. Unfortunately, studies showed hepatotoxicity of PMR during its clinical use. The mechanisms of its toxic action remain unknown. The major objectives of this study were to characterize oxidative metabolites of physcion in vitro and in vivo and to determine the electrophilicity of the parent compound and its oxidative metabolites...
April 18, 2018: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29667115/biopsy-feasibility-trial-for-breast-cancer-pathologic-complete-response-detection-after-neoadjuvant-chemotherapy-imaging-assessment-and-correlation-endpoints
#3
Gaiane M Rauch, Henry M Kuerer, Beatriz Adrada, Lumarie Santiago, Tanya Moseley, Rosalind P Candelaria, Elsa Arribas, Jia Sun, Jessica W T Leung, Savitri Krishnamurthy, Wei T Yang
PURPOSE: This study was designed to present the secondary imaging endpoints of the trial for evaluating mammogram (MMG), ultrasound (US) and image guided biopsy (IGBx) assessment of pathologic complete response (pCR) in breast cancer (BC) patients undergoing neoadjuvant chemotherapy (NAC). METHODS: Patients with T1-3, N0-3, M0 triple-negative or HER2-positive BC who received NAC were enrolled in an Institutional Review Board-approved prospective, clinical trial...
April 17, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29665402/n-acetylcysteine-inhibits-mancozeb-induced-impairments-to-the-normal-development-of-zebrafish-embryos
#4
Dennis Guilherme Costa-Silva, Luana Paganotto Leandro, Pratícia Brum Vieira, Nelson Rodrigues de Carvalho, Andressa Rubim Lopes, Lucia Emanueli Schimith, Mauro Eugênio Medina Nunes, Renata Siqueira de Mello, Illana Kemmerich Martins, Adriano Alves de Paula, Andrés Delgado Cañedo, José Cláudio Fonseca Moreira, Thais Posser, Jeferson Luis Franco
Mancozeb (MZ), a manganese/zinc-containing ethylene-bis-dithiocarbamate (EBCD) fungicide has been claimed to present low acute toxicity and short environmental persistence, however, its effects on embryogenesis in non-target organisms is unclear. Here, we used zebrafish embryos (5 hpf) to assess the potential embryotoxic effects induced by MZ (up to 72 hpf) as well as the role of reactive oxygen species (ROS) in this process by pre-treatment with a classical antioxidant (N-acetylcysteine, NAC). Markers of reactive oxygen species production (ROS), glutathione (GSH) levels and glutathione S-transferase (GST) activity were measured along with genotoxicity (comet assay), cell death (Acridine Orange) and behavioral parameters (spontaneous movement, touch stimulation and swimming response), in order to determine potential mechanisms of embryotoxicity...
April 14, 2018: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/29664829/nipple-sparing-mastectomy-and-immediate-breast-reconstruction-with-a-deep-inferior-epigastric-perforator-flap-a-study-of-patient-satisfaction
#5
Jerry Levy, Romain Bosc, Noel Warren, Sabban Rebecca, Thu Ha Dao, Barbara Hersant, Jean-Paul Meningaud
INTRODUCTION: The morphological result of nipple-areola complex (NAC) reconstruction may be disappointing for patients who undergo skin-sparing mastectomies and immediate breast reconstruction, followed by secondary reconstruction of the nipple-areola complex.The aim of this study was to analyze patient satisfaction after nipple-sparing mastectomy and immediate breast reconstruction with a deep inferior epigastric perforator flap. MATERIALS AND METHODS: Our retrospective study involved all patients who underwent an immediate breast reconstruction after unilateral mastectomy with conservation of the NAC...
April 17, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29663874/n-acetyl-cysteine-and-vitamin-d-supplementation-in-treatment-resistant-obsessive-compulsive-disorder-patients-a-general-review
#6
Flavia di Michele, Alberto Siracusano, Talamo Alessandra, Cinzia Niolu
OBJECTIVE: Obsessive-compulsive disorder (OCD) is a disabling mental illness for which pharmacological and psychosocial interventions are all too often inadequate. This demonstrates the need for more targeted therapeutics. Recent preclinical and clinical studies have implicated dysfunction of glutamatergic neurotransmission in the pathophysiology of OCD. Moreover there are studies suggesting that neuroimmune abnormalities may play an important role in the pathogenesis of OCD. N-acetyl cysteine (NAC) is a safe and readily available agent that would modify the synaptic release of glutamate in subcortical brain regions via modulation of the cysteine-glutamate antiporter...
April 17, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29662624/arsenic-trioxide-mediated-suppression-of-mir-182-5p-is-associated-with-potent-anti-oxidant-effects-through-up-regulation-of-sesn2
#7
Liang-Ting Lin, Shin-Yi Liu, Jyh-Der Leu, Chun-Yuan Chang, Shih-Hwa Chiou, Te-Chang Lee, Yi-Jang Lee
Arsenic trioxide (ATO) is a traditional Chinese medicine that can induce oxidative stress for treatment of cancer cells. However, ATO may generate anti-oxidative responses to compromise the cytotoxic effect, but the underlying mechanisms remain unclear. Here we found that ATO could inhibit miR-182-5p expression in patient-derived primary S1 glioblastoma (GBM) cells accompanied by up-regulation of Sestrin-2 ( SESN2 ) mRNA, a known anti-oxidant molecule. This phenomenon was also detected in a U87MG glioma cell line, human lung adenocarcinoma H1299 cell line and A549 cell line...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29661657/reprint-of-the-effect-of-n-acetylcysteine-and-working-memory-training-on-cocaine-use-craving-and-inhibition-in-regular-cocaine-users-correspondence-of-lab-assessments-and-ecological-momentary-assessment
#8
Mieke H J Schulte, Reinout W Wiers, Wouter J Boendermaker, Anna E Goudriaan, Wim van den Brink, Denise S van Deursen, Malte Friese, Emily Brede, Andrew J Waters
INTRODUCTION: Effective treatment for cocaine use disorder should dampen hypersensitive cue-induced motivational processes and/or strengthen executive control. Using a randomized, double-blind, placebo-controlled intervention, the primary aim of this study was to investigate the effect of N-Acetylcysteine (NAC) and working memory (WM)-training to reduce cocaine use and craving and to improve inhibition assessed in the laboratory and during Ecological Momentary Assessment (EMA). The second aim was to examine correspondence between laboratory and EMA data...
March 26, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29660403/ros-modifiers-and-nox4-affect-the-expression-of-the-survivin-associated-radio-adaptive-response
#9
Jeffrey S Murley, Jack L Arbiser, Ralph R Weichselbaum, David J Grdina
The survivin-associated radio-adaptive response can be induced following exposure to ionizing radiation in the dose range from 5 to 100 mGy, and its magnitude of expression is dependent upon the TP53 mutational status of cells and ROS signaling. The purpose of the study was to investigate the potential role of ROS in the development of the survivin-associated adaptive response. Utilizing human colon carcinoma HCT116 TP53 wild type (WT) and HCT116 isogenic TP53 null mutant (Mut) cell cultures, the roles of inter- and intracellular ROS signaling on expression of the adaptive response as evidenced by changes in intracellular translocation of survivin measured by ELISA, and cell survival determined by a standard colony forming assay were investigated using ROS modifying agents that include emodin, N-acetyl-l-cysteine (NAC), fulvene-5, honokiol, metformin and rotenone...
April 13, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29660332/dusp14-knockout-accelerates-cardiac-ischemia-reperfusion-ir-injury-through-activating-nf-%C3%AE%C2%BAb-and-mapks-signaling-pathways-modulated-by-ros-generation
#10
Bin Lin, Jing Xu, De-Guang Feng, Feng Wang, Jia-Xiang Wang, Hui Zhao
Inflammation and oxidative stress are significantly involved in the progression of a variety of diseases, including myocardial ischemia/reperfusion (IR). In the present study, we hypothesized a protective role of dual-specificity phosphatase 14 (DUSP14) in myocardial IR, as well as the underlying molecular mechanism. The results indicated that DUSP14 was down-regulated following cardiac IR injury. Subsequently, the wild type (WT) and DUSP14-knockout (KO) mice were included to further reveal the potential role of DUSP14 in cardiac IR injury progression...
April 13, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29659325/reactive-oxygen-species-mediates-50-hz-magnetic-field-induced-egf-receptor-clustering-via-acid-sphingomyelinase-activation
#11
Liyuan Sun, Liangjing Chen, Lina Bai, Yongpeng Xia, Xiaobo Yang, Wei Jiang, Wenjun Sun
PURPOSE: Exposure to extremely low frequency electromagnetic fields (ELF-MFs) could elicit biological effects including carcinogenesis. However, the detailed mechanisms by which these ELF-MFs interact with biological system are currently unclear. Previously, we found that a 50-Hz magnetic field (MF) exposure could induce epidermal growth factor receptor (EGFR) clustering and phosphorylation on cell membranes. In the present experiment, the possible roles of reactive oxygen species (ROS) in MF-induced EGFR clustering were investigated...
April 16, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29659022/transcription-factor-rd26-is-a-key-regulator-of-metabolic-reprogramming-during-dark-induced-senescence
#12
Iman Kamranfar, Gang-Ping Xue, Takayuki Tohge, Mastoureh Sedaghatmehr, Alisdair R Fernie, Salma Balazadeh, Bernd Mueller-Roeber
Leaf senescence is a key process in plants that culminates in the degradation of cellular constituents and massive reprogramming of metabolism for the recovery of nutrients from aged leaves for their reuse in newly developing sinks. We used molecular-biological and metabolomics approaches to identify NAC transcription factor (TF) RD26 as an important regulator of metabolic reprogramming in Arabidopsis thaliana. RD26 directly activates CHLOROPLAST VESICULATION (CV), encoding a protein crucial for chloroplast protein degradation, concomitant with an enhanced protein loss in RD26 overexpressors during senescence, but a reduced decline of protein in rd26 knockout mutants...
April 16, 2018: New Phytologist
https://www.readbyqxmd.com/read/29658920/identification-of-dopamine-d1-alpha-receptor-within-rodent-nucleus-accumbens-by-an-innovative-rna-in-situ-detection-technology
#13
Hailong Li, Jessica M Illenberger, Kristen A McLaurin, Charles F Mactutus, Rosemarie M Booze
In the central nervous system, the D1-alpha subtype receptor (Drd1α) is the most abundant dopamine (DA) receptor, which plays a vital role in regulating neuronal growth and development. However, the mechanisms underlying Drd1α receptor abnormalities mediating behavioral responses and modulating working memory function are still unclear. Using a novel RNA in situ hybridization assay, the current study identified dopamine Drd1α receptor and tyrosine hydroxylase (TH) RNA expression from DA-related circuitry in the nucleus accumbens (NAc) area and substantia nigra region (SNR), respectively...
March 27, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29657089/mechanistic-target-of-rapamycin-mtor-protein-expression-in-the-tumor-and-its-microenvironment-correlates-with-more-aggressive-pathology-at-cystectomy
#14
Brian R Winters, Funda Vakar-Lopez, Lisha Brown, Bruce Montgomery, Roland Seiler, Peter C Black, Joost L Boormans, Marc Dall Era, Elai Davincioni, James Douglas, Ewan A Gibb, Bas W G van Rhijn, Michiel S van der Heijden, Andrew C Hsieh, Jonathan L Wright, Hung-Ming Lam
BACKGROUND: The mechanistic target of rapamycin (mTOR) has been implicated in driving tumor biology in multiple malignancies, including urothelial carcinoma (UC). We investigate how mTOR and phosphorylated mTOR (pmTOR) protein expression correlate with chemoresponsiveness in the tumor and its microenvironment at final pathologic staging after neoadjuvant chemotherapy (NAC). METHODS: A single-institution retrospective analysis was performed on 62 patients with cT2-4Nany UC undergoing NAC followed by radical cystectomy...
April 12, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29656874/regional-heterogeneity-of-d2-receptor-signaling-in-the-dorsal-striatum-and-nucleus-accumbens
#15
Pamela F Marcott, Sheng Gong, Prashant Donthamsetti, Steven G Grinnell, Melissa N Nelson, Amy H Newman, Lutz Birnbaumer, Kirill A Martemyanov, Jonathan A Javitch, Christopher P Ford
Dopamine input to the dorsal and ventral striatum originates from separate populations of midbrain neurons. Despite differences in afferent inputs and behavioral output, little is known about how dopamine release is encoded by dopamine receptors on medium spiny neurons (MSNs) across striatal subregions. Here we examined the activation of D2 receptors following the synaptic release of dopamine in the dorsal striatum (DStr) and nucleus accumbens (NAc) shell. We found that D2 receptor-mediated synaptic currents were slower in the NAc and this difference occurred at the level of D2-receptor signaling...
April 10, 2018: Neuron
https://www.readbyqxmd.com/read/29656300/the-sineoculis-homeobox-homolog-1-six1-gene-regulates-paclitaxel-resistance-by-affecting-reactive-oxygen-species-and-autophagy-in-human-hepatocellular-carcinoma-cell-line-hepg2
#16
Baowei Li, Shahe Zhao, Ruipeng Geng, Zhongchao Huo, Hui Zhang
BACKGROUND The objective of this study was to explore the role of SIX1 in paclitaxel (TAX) resistance of HepG2 cells via reactive oxygen species (ROS) and autophagy pathway. MATERIAL AND METHODS Hepatoma cell line HepG2 was treated with SIX1 knockdown or/and TAX. Cell growth was detected by MTT assay and colony formation assay. Cell apoptosis was evaluated with flow cytometry. ROS levels were detected using flow cytometry (stained with DCFH2-DA). Western blot was conducted to detect the expression of SIX1 and autophagy-related proteins...
April 15, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29656008/identification-of-mirnas-linked-with-the-drought-response-of-tef-eragrostis-tef-zucc-trotter
#17
Federico Martinelli, Gina Cannarozzi, Bipin Balan, Fredy Siegrist, Annett Weichert, Regula Blösch, Zerihun Tadele
Tef [Eragrostis tef (Zucc.) Trotter], a staple food crop in the Horn of Africa and particularly in Ethiopia, has several beneficial agronomical and nutritional properties, including waterlogging and drought tolerance. In this study, we performed microRNA profiling of tef using the Illumina HiSeq 2500 platform, analyzing both shoots and roots of two tef genotypes, one drought-tolerant (Tsedey) and one drought-susceptible (Alba). We obtained more than 10 million filtered reads for each of the 24 sequenced small cDNA libraries...
March 29, 2018: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29655793/inhibition-of-nlrp9b-attenuates-acute-lung-injury-through-suppressing-inflammation-apoptosis-and-oxidative-stress-in-murine-and-cell-models
#18
Qiu Yanling, Cheng Xiaoning, Bai Fei, Fang Liyun, Hu Huizhong, Sun Daqing
Acute lung injury (ALI), known a severe disease along with high morbidity and mortality, is lacking of specific therapies. Inflammation, apoptosis and oxidative stress are critical pathologies that contribute to ALI. Recently, there is study indicated that NLRP9b, a NOD-like receptor (NLR) member, is critical in modulation of inflammatory response. However, the effects of NLRP9b on sepsis-associated ALI, and the underlying molecular mechanism have not been understood. In the present study, the wild type (WT) and NLRP9b-knockout (NLRP9b-/- ) mice with C57B/L6 background were subjected to a cecal ligation and puncture (CLP) for ALI murine model establishment...
April 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29651385/clinicopathological-predictors-of-long-term-benefit-in-breast-cancer-treated-with-neoadjuvant-chemotherapy
#19
Marco Galvez, Carlos A Castaneda, Joselyn Sanchez, Miluska Castillo, Lia Pamela Rebaza, Gabriela Calderon, Miguel De La Cruz, Jose Manuel Cotrina, Julio Abugattas, Jorge Dunstan, Henry Guerra, Omar Mejia, Henry L Gomez
AIM: To investigate the survival impact of clinicopathological factors, including pathological complete response (pCR) and tumor-infiltrating lymphocytes (sTIL) levels according to subtypes, in breast cancer (BC) patients who received neo-adjuvant chemotherapy (NAC). METHODS: We evaluated 435 BC patients who presented and received NAC at the Instituto Nacional de Enfermedades Neoplasicas from 2003 to 2014. sTIL was analyzed as the proportion of tumor stroma occupied by lymphocytes, and was prospectively evaluated on hematoxylin and eosin-stained sections of the preNAC core biopsy...
April 10, 2018: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29651294/lateral-root-development-in-potato-is-mediated-by-stu-mi164-regulation-of-nac-transcription-factor
#20
Li Zhang, Lei Yao, Ning Zhang, Jiangwei Yang, Xi Zhu, Xun Tang, Alejandro Calderón-Urrea, Huaijun Si
The NAC designation is derived from petunia ( Petunia hybrida ) gene NO APICAL MERISTEM ( NAM ) and Arabidopsis genes ATAF1/ATAF2 and CUP-SHAPED COTYLEDON2 ( CUC2 ), which belongs to the family of plant-specific transcription factors (TFs), and plays important role in plant development processes, such as response to biotic and abiotic stress, and hormone signaling. MicroRNAs (miRNAs) are a class of small, non-coding endogenous RNAs which play versatile and significant role in plant stress response and development via negatively affecting gene expression at a post-transcriptional level...
2018: Frontiers in Plant Science
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