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https://www.readbyqxmd.com/read/28730564/a-new-approach-to-assess-occupational-exposure-to-airborne-fungal-contamination-and-mycotoxins-of-forklift-drivers-in-waste-sorting-facilities
#1
Carla Viegas, Tiago Faria, Ana Cebola de Oliveira, Liliana Aranha Caetano, Elisabete Carolino, Anita Quintal-Gomes, Magdalena Twarużek, Robert Kosicki, Ewelina Soszczyńska, Susana Viegas
The waste management industry is an important employer, and exposure of waste-handling workers to microorganisms is considered an occupational health problem. Besides fungal contamination, it is important to consider the co-occurrence of mycotoxins in this setting. Forklifts with closed cabinet and air conditioner are commonly used in waste industry to transport waste and other products within the facilities, possibly increasing the risk of exposure under certain conditions. The aim of this study was to assess the fungal contamination and mycotoxin levels in filters from the air conditioning system of forklift cabinets, as an indicator to assess occupational exposure of the drivers working in a waste sorting facility...
July 20, 2017: Mycotoxin Research
https://www.readbyqxmd.com/read/28730251/severe-upper-gastrointestinal-bleeding-determined-by-a-gastric-lymphoma-associated-with-helicobacter-pylori-positive-atrophic-gastritis
#2
Cosmin Vasile Obleagă, Cristin Constantin Vere, Ana Maria Pătraşcu, Emil Moraru, Antoanela Valentina Crafciuc, Maria Camelia Foarfă, Stelian ŞtefăniŢă Mogoantă, Costin Teodor Streba, Simona Bondari, Ştefan Paitici, Cecil Sorin Mirea, Ionică Daniel Vîlcea
The pathogenesis of gastric cancer regardless of histological structure is a classic example of gene-environment interaction, and an important epidemiological aspect was the recognized association with Helicobacter pylori infection. This paper describes a case of gastric mucosa-associated lymphoid tissue (MALT) lymphoma in a young patient whose first sign of the disease was upper gastrointestinal bleeding and associated hemorrhagic shock. The patient is a 31-year-old man, diagnosed by endoscopy 10 years ago with H...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28723182/cross-linked-gold-nanoparticle-membrane-resonators-as-microelectromechanical-vapor-sensors
#3
Hendrik Schlicke, Malte Behrens, Clemens J Schröter, Gregor T Dahl, Hauke Hartmann, Tobias Vossmeyer
We report a novel approach for the detection of volatile compounds employing electrostatically driven drumhead resonators as sensing elements. The resonators are based on freestanding membranes of alkanedithiol cross-linked gold nanoparticles (GNPs), which are able to sorb analytes from the gas phase. Under reduced pressure, the fundamental resonance frequency of a resonator is continuously monitored while the device is exposed to varying partial pressures of toluene, 4-methylpentan-2-one, 1-propanol, and water...
April 28, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28720586/a-malt-lymphoma-prognostic-index-generated-from-the-dataset-of-the-ielsg-19-prospective-clinical-trial
#4
Catherine Thieblemont, Luciano Cascione, Annarita Conconi, Barbara Kiesewetter, Markus Raderer, Gianluca Gaidano, Maurizio Martelli, Daniele Laszlo, Bertrand Coiffier, Armando Lopez Guillermo, Valter Torri, Franco Cavalli, Peter W Johnson, Emanuele Zucca
There are no widely accepted prognostic indices for extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). This study aimed to develop and validate a specific prognostic tool to personalize and optimize lymphoma treatment of patients with MALT lymphoma. A prognostic index was built by Cox regression (stepwise selection) using data from 401 patients enrolled in the international randomized IELSG-19 trial (NCT 00210353). A validation set, including 633 patients, was obtained by merging three independent cohorts of MALT lymphoma patients...
July 18, 2017: Blood
https://www.readbyqxmd.com/read/28719804/maternal-obesity-attenuates-predelivery-inflammatory-reaction-in-c57bl-6n-mice
#5
Sarah Appel, Merle Schulze-Edinghausen, Tobias Kretschmer, Sarah Storck, Ruth Janoschek, Inga Bae-Gartz, Marion Handwerk, Maria Wohlfarth, Kai-Dietrich Nüsken, Eva Hucklenbruch-Rother, Malte Heykants, Esther Mahabir, Jörg Dötsch
Inflammation and oxidative stress are known to increase before labour. Whether gonadal white adipose tissue (gWAT) participates in this process and whether labour-related processes in placental and adipose tissue are altered in obese women is unknown. In our mouse model, lean mice display elevated placental inflammation and oxidative stress towards the end of pregnancy, accompanied by an increased expression of pro-inflammatory factors in gWAT. Obese mice also display elevated levels of pro-inflammatory factors and oxidative stress in placentas shortly before birth...
July 1, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28719100/deuteration-of-hyperpolarized-%C3%A2-%C3%A2-c-labelled-zymonic-acid-enables-sensitivity-enhanced-dynamic-mri-of-ph
#6
Christian Hundshammer, Stephan Düwel, Simone Köcher, Malte Gersch, Benedikt Feuerecker, Christoph Scheurer, Axel Haase, Steffen J Glaser, Markus Schwaiger, Franz Schilling
Aberrant pH is characteristic of many pathologies such as ischemia, inflammation or cancer. Therefore, a non-invasive and spatially resolved pH determination is valuable for disease diagnosis, characterization of response to treatment and the design of pH-sensitive drug delivery systems. We recently introduced hyperpolarized zymonic acid (ZA) as a novel MRI probe of extracellular pH utilizing dissolution dynamic polarization (DNP) for a more than 10,000-fold NMR signal enhancement. Here we present a strategy to enhance the sensitivity of this approach by deuteration of ZA (ZAd)...
July 18, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28714985/electrical-pumping-and-tuning-of-exciton-polaritons-in-carbon-nanotube-microcavities
#7
Arko Graf, Martin Held, Yuriy Zakharko, Laura Tropf, Malte C Gather, Jana Zaumseil
Exciton-polaritons are hybrid light-matter particles that form upon strong coupling of an excitonic transition to a cavity mode. As bosons, polaritons can form condensates with coherent laser-like emission. For organic materials, optically pumped condensation was achieved at room temperature but electrically pumped condensation remains elusive due to insufficient polariton densities. Here we combine the outstanding optical and electronic properties of purified, solution-processed semiconducting (6,5) single-walled carbon nanotubes (SWCNTs) in a microcavity-integrated light-emitting field-effect transistor to realize efficient electrical pumping of exciton-polaritons at room temperature with high current densities (>10 kA cm(-2)) and tunability in the near-infrared (1,060 nm to 1,530 nm)...
July 17, 2017: Nature Materials
https://www.readbyqxmd.com/read/28714751/antidepressant-efficacy-of-electroconvulsive-therapy-is-associated-with-a-reduction-of-the-innate-cellular-immune-activity-in-the-cerebrospinal-fluid-in-patients-with-depression
#8
Laura Kranaster, Carolin Hoyer, Suna S Aksay, J Malte Bumb, Norbert Müller, Peter Zill, Markus J Schwarz, Alexander Sartorius
OBJECTIVES: A bidirectional link between the antidepressant effects of electroconvulsive therapy (ECT) and the modulation of the immune system has been proposed. To elucidate the interplay between antidepressant treatment and macrophage/microglia activation in humans, we performed a study on the effects of the antidepressant treatment by ECT on markers of macrophage/microglia activation in patients with depression. METHODS: We measured six different markers (IL-6, neopterin, sCD14, sCD163 MIF and MCP1) of macrophage/microglia activation in the cerebrospinal fluid (CSF) and blood of 12 patients with a severe, treatment-resistant depressive episode before and after a course of ECT...
July 17, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28713841/design-and-implementation-of-an-optimal-laser-pulse-front-tilting-scheme-for-ultrafast-electron-diffraction-in-reflection-geometry-with-high-temporal-resolution
#9
Francesco Pennacchio, Giovanni M Vanacore, Giulia F Mancini, Malte Oppermann, Rajeswari Jayaraman, Pietro Musumeci, Peter Baum, Fabrizio Carbone
Ultrafast electron diffraction is a powerful technique to investigate out-of-equilibrium atomic dynamics in solids with high temporal resolution. When diffraction is performed in reflection geometry, the main limitation is the mismatch in group velocity between the overlapping pump light and the electron probe pulses, which affects the overall temporal resolution of the experiment. A solution already available in the literature involved pulse front tilt of the pump beam at the sample, providing a sub-picosecond time resolution...
July 2017: Structural Dynamics (Melville, N.Y.)
https://www.readbyqxmd.com/read/28712656/treatments-for-ocular-adnexal-lymphoma-a-report-by-the-american-academy-of-ophthalmology
#10
Michael T Yen, Jurij R Bilyk, Edward J Wladis, Elizabeth A Bradley, Louise A Mawn
PURPOSE: To review the literature to determine the efficacy of available treatments for ocular adnexal lymphoma (OAL) and to evaluate the outcomes and complications of treatments in patients older than 13 years. METHODS: A literature search was conducted last in March 2017 in the PubMed and Cochrane Library databases for English-language original research investigations that evaluated treatment outcomes for OAL. The searches identified 307 unique citations, and 27 studies were selected according to the criteria outlined for this assessment...
July 13, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28710853/real-world-effectiveness-of-sofosbuvir-based-treatment-regimens-for-chronic-hepatitis-c-genotype-3-infection-results-from-the-multicenter-german-hepatitis-c-cohort-gecco-03
#11
Malte H Wehmeyer, Patrick Ingiliz, Stefan Christensen, Dietrich Hueppe, Thomas Lutz, Karl Georg Simon, Knud Schewe, Christoph Boesecke, Axel Baumgarten, Heiner Busch, Juergen Rockstroh, Guenther Schmutz, Torben Kimhofer, Florian Berger, Stefan Mauss, Julian Schulze Zur Wiesch
There are limited data regarding the real world effectiveness of direct acting antivirals (DAA) for the therapy of chronic genotype 3 hepatitis C virus (HCV) infection. All HCV genotype 3 infected patients from the German hepatitis C cohort (GECCO), which is a prospective database of nine German hepatitis C treatment centers, were included in the study. 342 chronically infected HCV genotype 3 patients were analyzed (253 males [74.0%], mean age 47.3 years, 127 cirrhotic patients [37.1%] mostly with Child A cirrhosis, 113 treatment experienced patients [37...
July 15, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28710503/rac1-mediated-cardiac-damage-causes-diastolic-dysfunction-in-a-mouse-model-of-subacute-doxorubicin-induced-cardiotoxicity
#12
Jan Ohlig, Christian Henninger, Simone Zander, Marc Merx, Malte Kelm, Gerhard Fritz
The anticancer efficacy of anthracyclines is limited by congestive heart failure. Clinically established markers of early onset of cardiotoxicity following anthracycline treatment and preventive measures are missing. Although statins are reported to alleviate anthracycline-induced cardiotoxicity in vivo, the molecular mechanisms involved remain elusive. In vitro data point to Rac1 as major target of the cytoprotective statin effects. Here we investigated whether specific inhibition of Rac1 by NSC23766 is as effective as lovastatin in preventing subacute cardiotoxicity following doxorubicin treatment...
July 14, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28710240/a-rare-case-of-gastric-mixed-adenoneuroendocrine-carcinoma-manec-with-gastric-helicobacter-pylori-negative-mucosa-associated-lymphoid-tissue-malt-lymphoma
#13
Babikir Kheiri, Mohammed Osman, Douglas Congdon, Ghassan Bachuwa
No abstract text is available yet for this article.
July 14, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28710097/germinal-centres-in-diagnostic-labial-gland-biopsies-of-patients-with-primary-sj%C3%A3-gren-s-syndrome-are-not-predictive-for-parotid-malt-lymphoma-development
#14
Erlin A Haacke, Bert van der Vegt, Arjan Vissink, Fred K L Spijkervet, Hendrika Bootsma, Frans G M Kroese
OBJECTIVE: Patients with primary Sjögren's syndrome (pSS) have an increased risk of developing non-Hodgkin's lymphoma (NHL), particularly parotid gland mucosa-associated lymphoid tissue (MALT) lymphomas. Presence of germinal centres (GCs) in labial gland biopsies has been suggested as predictive factor for NHL. We assessed whether presence of GCs is increased in labial gland biopsies from patients with pSS who developed parotid MALT lymphoma, the dominant NHL-subtype in pSS, compared with patients with pSS who did not develop lymphoma...
July 14, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28709887/frequency-and-prognostic-value-of-pten-loss-in-patients-with-upper-tract-urothelial-carcinoma-treated-with-radical-nephroureterectomy
#15
Malte Rieken, Shahrokh F Shariat, Jose A Karam, Beat Foerster, Francesca Khani, Kilian Gust, Mohammad Abufaraj, Christopher G Wood, Alon Z Weizer, Jay D Raman, Charles C Guo, Nathalie Rioux-Leclercq, Andrea Haitel, Karim Bensalah, Yair Lotan, Alexander Bachmann, Angelo M De Marzo, Brian D Robinson, Vitaly Margulis
PURPOSE: The frequency and prognostic significance of phosphatase and tensin homolog (PTEN) protein expression in upper tract urothelial carcinoma (UTUC) have not been investigated yet in large studies. To analyze PTEN protein status and its association with disease recurrence and survival outcomes in a large, multi-institutional UTUC cohort. MATERIALS AND METHODS: Retrospective analysis of 611 patients with UTUC treated with radical nephroureterectomy (RNU) between 1991 and 2008 at seven institutions...
July 11, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28709768/plasma-sphingosine-1-phosphate-concentrations-are-associated-with-systolic-heart-failure-in-patients-with-ischemic-heart-disease
#16
Amin Polzin, Kerstin Piayda, Petra Keul, Lisa Dannenberg, Annemarie Mohring, Markus Gräler, Tobias Zeus, Malte Kelm, Bodo Levkau
OBJECTIVE: Sphingosine-1-Phosphate (S1P) is a bioactive sphingolipid with important functions in immunity, inflammation and cardiovascular biology. S1P is associated with prevalence and severity of coronary artery disease and myocardial infarction. However, its relevance in ischemic cardiomyopathy is unknown. We aimed to investigate associations of plasma S1P and other sphingolipids with the extent of heart failure in patients with ischemic heart disease. METHODS AND RESULTS: 74 patients with ischemic heart disease were investigated in this observational study...
July 12, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28706520/hypothermia-promotes-interleukin-22-expression-and-fine-tunes-its-biological-activity
#17
Evgeny Chichelnitskiy, Britta Himmelseher, Malte Bachmann, Josef Pfeilschifter, Heiko Mühl
Disturbed homeostasis as a result of tissue stress can provoke leukocyte responses enabling recovery. Since mild hypothermia displays specific clinically relevant tissue-protective properties and interleukin (IL)-22 promotes healing at host/environment interfaces, effects of lowered ambient temperature on IL-22 were studied. We demonstrate that a 5-h exposure of endotoxemic mice to 4°C reduces body temperature by 5.0° and enhances splenic and colonic il22 gene expression. In contrast, tumor necrosis factor-α and IL-17A were not increased...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28702966/possible-role-of-helicobacter-pylori-in-diseases-of-dermatological-interest
#18
C Guarneri, J Lotti, M Fioranelli, M G Roccia, T Lotti, F Guarneri
Helicobacter pylori is a gram-negative, flagellate, microaerophilic bacterium identified for the first time about 30 years ago, as a pathogenic factor of gastritis and peptic ulcer. Soon after, it was linked to several gastrointestinal and extra-gastrointestinal diseases (hematological, cardiovascular, neurological, pulmonary and ocular diseases, obesity, diabetes mellitus, growth retardation and extragastric MALT lymphoma). Association and possible cause-effect correlation with H. pylori infection were suggested in diseases of dermatological interest such as chronic urticaria, rosacea, Henoch-Schoenleins purpura, idiopathic thrombocytopenic purpura, cutaneous and oral lichen planus, atopic dermatitis, recurrent aphthous stomatitis, systemic sclerosis, psoriasis, Sjögrens syndrome, Behçet's disease, pruritus, alopecia areata, primary cutaneous marginal zone B-cell lymphomas, vitiligo, chronic prurigo, multiformis, prurigo nodularis, leukocytoclastic vasculitis, prurigo pigmentosa, eczema nummulare, primary cutaneous MALT-type lymphoma, sublamina densa-type linear IgA bullous dermatosis, Sweet's syndrome, cutaneous T-cell pseudolymphoma and pemphigus vulgaris...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28699415/a-scalable-approach-for-the-generation-of-human-pluripotent-stem-cell-derived-hepatic-organoids-with-sensitive-hepatotoxicity-features
#19
Malte Sgodda, Zhen Dai, Robert Zweigerdt, Amar D Sharma, Michael Ott, Tobias Cantz
The quest for physiologically-active human hepatocyte-like cells for in vitro research and drug screening is high. The recent progress in the field of pluripotent stem cell (PSC) - derived hepatic cells within the last decade brings those cells closer to applications in translational medicine. However, the classical two-dimensional (2D) cell culture systems are of limited use, because relevant cell-cell interactions based on cell polarity, which is a major prerequisite for proper hepatic cell metabolisms, are not provided...
July 12, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28696461/room-temperature-in-cell-epr-spectroscopy-alpha-synuclein-disease-variants-remain-intrinsically-disordered-in-the-cell
#20
Julia Cattani, Vinod Subramaniam, Malte Drescher
Human alpha-Synuclein (aS), implicated in Parkinson's disease, adopts a rich variety of different conformations depending on the macromolecular context. In order to unravel its pathophysiological role, monitoring its intracellular conformational state and identifying differences for the disease variants is crucial. Here, we present an intracellular spectroscopy approach based on a systematic spin-labeling site-scan in combination with intracellular electron paramagnetic resonance spectroscopy determining conformations on a molecular scale...
July 11, 2017: Physical Chemistry Chemical Physics: PCCP
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