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https://www.readbyqxmd.com/read/29331942/sucrase-isomaltase-15phe-ibs-risk-variant-in-relation-to-dietary-carbohydrates-and-faecal-microbiota-composition
#1
Louise Thingholm, Malte Rühlemann, Jun Wang, Matthias Hübenthal, Wolfgang Lieb, Matthias Laudes, Andre Franke, Mauro D'Amato
No abstract text is available yet for this article.
January 13, 2018: Gut
https://www.readbyqxmd.com/read/29331841/culture-beats-gender-the-importance-of-controlling-for-identity-and-parenting-related-risk-factors-in-adolescent-psychopathology
#2
Inge Seiffge-Krenke, Malte Persike, Elias Besevegis, Cecilia Chau, Neslihan Güney Karaman, Lyda Lannegrand-Willems, Katharzyna Lubiewska, Iffat Rohail
This study analyzed the unique effects of gender and culture on psychopathology in adolescents from seven countries after controlling for factors which might have contributed to variations in psychopathology. In a sample 2259 adolescents (M = 15 years; 54% female) from France, Germany, Turkey, Greece, Peru, Pakistan, and Poland identity stress, coping with identity stress, maternal parenting (support, psychological control, anxious rearing) and psychopathology (internalizing, externalizing and total symptomatology) were assessed...
January 10, 2018: Journal of Adolescence
https://www.readbyqxmd.com/read/29331570/meningeal-marginal-zone-b-cell-lymphoma-the-meningioma-trap
#3
Alexandre Villeneuve, François Rubin, Pierre Bonfils
OBJECTIVE: To report a case of marginal zone MALT lymphoma of the temporal dura mater, initially mistaken for temporal meningioma. CASE REPORT: A 60-year-old immunocompetent woman, followed for more than 10 years for temporal meningioma causing vertigo and mixed hearing loss, presented with cervical lymphadenopathy, revealing marked progression of an intracranial lesion, leading to a diagnosis of marginal zone MALT lymphoma based on histological examination of a cervical lymph node...
January 10, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29327175/microrna-30c-as-a-novel-diagnostic-biomarker-for-primary-and-secondary-b-cell-lymphoma-of-the-cns
#4
Alexander Baraniskin, Monika Chomiak, Guido Ahle, Thomas Gress, Malte Buchholz, Michael Turewicz, Martin Eisenacher, Michelle Margold, Uwe Schlegel, Wolff Schmiegel, Stephan Hahn, Roland Schroers
Primary lymphomas of the central nervous system (PCNSL) are highly aggressive tumors affecting exclusively the CNS, meninges, and eyes. PCNSL must be separated from secondary spread of systemic lymphoma to the CNS (SCNSL), which may occur at diagnosis or relapse of systemic lymphomas. At present, there are no valid methods to distinguish PCNSL from SCNSL based on tumor biopsy because of similar histological presentation. However, SCNSL and PCNSL are different in terms of prognosis and adequate therapy protocols...
January 11, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29325921/energy-flux-the-link-between-multitrophic-biodiversity-and-ecosystem-functioning
#5
REVIEW
Andrew D Barnes, Malte Jochum, Jonathan S Lefcheck, Nico Eisenhauer, Christoph Scherber, Mary I O'Connor, Peter de Ruiter, Ulrich Brose
Relating biodiversity to ecosystem functioning in natural communities has become a paramount challenge as links between trophic complexity and multiple ecosystem functions become increasingly apparent. Yet, there is still no generalised approach to address such complexity in biodiversity-ecosystem functioning (BEF) studies. Energy flux dynamics in ecological networks provide the theoretical underpinning of multitrophic BEF relationships. Accordingly, we propose the quantification of energy fluxes in food webs as a powerful, universal tool for understanding ecosystem functioning in multitrophic systems spanning different ecological scales...
January 8, 2018: Trends in Ecology & Evolution
https://www.readbyqxmd.com/read/29325249/-clinicopathologic-features-of-primary-hepatic-marginal-zone-lymphoma-of-mucosa-associated-lymphoid-tissue-and-hepatic-pseudolymphoma
#6
C Liu, X Li, H Li, Q X Gong, Y Li, Z Wang, Z H Zhang
Objective: To study the clinicopathological features of primary hepatic extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT lymphoma) and hepatic pseudolymphoma, and to discuss their differential diagnosis, treatment and prognosis. Methods: Three primary hepatic MALT lymphomas and two hepatic pseudolymphomas collected from January 2012 to March 2017 in the First Affiliated Hospital of Nanjing Medical University were evaluated by HE and immunohistochemistry(IHC), in-situ hybridization and immunoglobulin (Ig) gene rearrangement detection, and the relevant literature reviewed...
January 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29321210/the-immune-checkpoint-modulator-ox40-and-its-ligand-ox40l-in-nk-cell-immunosurveillance-and-acute-myeloid-leukemia
#7
Tina Nuebling, Carla Emilia Schumacher, Martin Hofmann, Ilona Hagelstein, Benjamin Joachim Schmiedel, Stefanie Maurer, Birgit Federmann, Kathrin Rothfelder, Malte Roerden, Daniela Dorfel, Pascal Schneider, Gundram Jung, Helmut Rainer Salih
The TNF receptor family member OX40 promotes activation and proliferation of T cells, which fuels efforts to modulate this immune checkpoint to reinforce antitumor immunity. Besides T cells, NK cells are a second cytotoxic lymphocyte subset that contributes to antitumor immunity, particularly in leukemia. Accordingly, these cells are being clinically evaluated for cancer treatment through multiple approaches, such as adoptive transfer of ex vivo expanded polyclonal NK cells (pNKC). Here we analyzed whether and how OX40 and its ligand (OX40L) influence NK-cell function and anti-leukemia reactivity...
January 10, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29319513/production-characterization-and-valuable-applications-of-exopolysaccharides-from-marine-bacillus-subtilis-sh1
#8
Sahar W M Hassan, Hassan A H Ibrahim
Exopolysaccharides (EPSs) are high molecular weight polymers consisting of different sugar residues they are preferable for replacing synthetic polymers as they are degradable and nontoxic. Many microorganisms possess the ability to synthesize and excrete exopolysaccharides with novel chemical compositions, properties and structures to have potential applications in different fields. The present study attempt to optimize the production of EPS by marine Bacillus subtilis SH1 in addition to characterization and investigation of different valuable applications...
December 4, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/29318237/sustainable-terpene-based-polyamides-via-anionic-polymerization-of-a-pinene-derived-lactam
#9
Malte Winnacker, Jacob Sag
A sustainable lactam, which is derived from the renewable terpene β-pinene, is converted to polyamides via a convenient anionic ring-opening polymerization (ROP), which can be easily handled without the use of a costly catalyst. The resulting polyamides have prosperous thermal properties, which enable their future use as high-performance polymers.
January 10, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29316577/-combination-of-nafld-fibrosis-score-and-liver-stiffness-measurement-for-identification-of-moderate-fibrosis-stages-ii-iii-in-non-alcoholic-fatty-liver-disease
#10
Andreas Drolz, Malte Wehmeyer, Tom Diedrich, Felix Piecha, Julian Schulze Zur Wiesch, Johannes Kluwe
INTRODUCTION:  Non-alcoholic fatty liver disease (NAFLD) has become one of the most frequent causes of chronic liver disease. Currently, therapeutic options for NAFLD patients are limited, but new pharmacologic agents are being investigated in the course of clinical trials. Because most of these studies are focusing on patients with fibrosis stages II and III (according to Kleiner), non-invasive identification of patients with intermediate fibrosis stages (II and III) is of increasing interest...
January 2018: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29316575/time-trend-of-reported-cases-and-publications-hepatitis-e-in-comparison-to-hepatitis-a%C3%A2-%C3%A2-d-in-germany-from-2001-to-2016
#11
Malte H Wehmeyer, Johannes Hartl, Moritz von Wulffen, Ansgar W Lohse, Sven Pischke
BACKGROUND:  The frequency of autochthonous hepatitis E virus (HEV) infections in Western countries has increased since the millennium, probably due to a higher awareness for HEV. The aim of this study was to analyze the epidemiological situation and regional distribution of HEV in comparison to hepatitis A - D in Germany. METHODS:  Data of the reported cases, patients' travel histories, and the regional distribution of hepatitis A - E virus infections from 2001 to 2017 were extracted from databases of the Robert Koch Institute...
January 2018: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29316464/comparison-of-tolerance-and-biosorption-of-three-trace-metals-cd-cu-pb-by-the-soil-fungus-absidia-cylindrospora
#12
Quentin Albert, Lydia Leleyter, Mélanie Lemoine, Natacha Heutte, Jean-Philippe Rioult, Lucile Sage, Fabienne Baraud, David Garon
Trace metals cause deterioration of the soil and constitute a major concern for the environment and human health. Bioremediation could be an effective solution for the rectification of contaminated soils. Fungi could play an important role in biodegradation because of the morphology of their mycelium (highly reactive and extensive biological surface) and its physiology (high tolerance to many stresses, production of enzymes and secondary metabolites). Fungi can effectively biosequestrate, or biotransform many organic and inorganic contaminants into a non-bioavailable form...
December 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/29315745/aspergillus-niger-mutants-affected-in-conidial-pigmentation-do-not-have-an-increased-susceptibility-to-water-stress-during-growth-at-low-water-activity
#13
Frank J J Segers, Han A B Wösten, Jan Dijksterhuis
Aspergillus niger forms conidia that contain melanin in their cell wall. This black pigment has been shown to protect fungi against UV-radiation and experimental evidence has indicated that it also protects against drought and high salt concentrations. In this study, growth of A. niger was evaluated at low water activity (aw ) and after changes in relative humidity (RH). In addition, deletion strains of A. niger affected in the melanin synthesis pathway were compared. Germination of conidia of the wild-type and deletion strains was observed at 0...
January 8, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29312579/deletion-lengthening-at-chromosomes-6q-and-16q-targets-multiple-tumor-suppressor-genes-and-is-associated-with-an-increasingly-poor-prognosis-in-prostate-cancer
#14
Martina Kluth, Simon Jung, Omar Habib, Mina Eshagzaiy, Anna Heinl, Nina Amschler, Sawinee Masser, Malte Mader, Frederic Runte, Philipp Barow, Sohall Frogh, Jazan Omari, Christina Möller-Koop, Claudia Hube-Magg, Joachim Weischenfeldt, Jan Korbel, Stefan Steurer, Till Krech, Hartwig Huland, Markus Graefen, Sarah Minner, Guido Sauter, Thorsten Schlomm, Ronald Simon
Prostate cancer is characterized by recurrent deletions that can considerably vary in size. We hypothesized that large deletions develop from small deletions and that this "deletion lengthening" might have a "per se" carcinogenic role through a combinatorial effect of multiple down regulated genes. In vitro knockdown of 37 genes located inside the 6q12-q22 deletion region identified 4 genes with additive tumor suppressive effects, further supporting a role of the deletion size for cancer aggressiveness. Employing fluorescence in-situ hybridization analysis on prostate cancer tissue microarrays, we determined the deletion size at 6q and 16q in more than 3,000 tumors...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29307560/the-association-between-objectively-measured-physical-activity-depression-cognition-and-health-related-quality-of-life-in-parkinson-s-disease
#15
Janet M T van Uem, Bernhard Cerff, Malte Kampmeyer, Jos Prinzen, Menno Zuidema, Markus A Hobert, Susanne Gräber, Daniela Berg, Walter Maetzler, Inga Liepelt-Scarfone
BACKGROUND: Lower levels of physical activity are associated with lower Health-Related Quality of Life (HRQoL) in Parkinson's disease (PD). We evaluated the influence of quantitative physical activity parameters among other (disease-related) features representing other domains of the WHO International model for classification of Function, Disability, and Health (ICF) on HRQoL in PD. METHODS: Home-based movement data (DynaPort MiniMod®) was collected in 47 PD patients...
December 23, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29304185/high-body-mass-index-is-a-risk-factor-for-difficult-deep-sedation-in-percutaneous-mitral-valve-repair
#16
Katharina Hellhammer, Shazia Afzal, Renate Tigges, Maximilian Spieker, Tienush Rassaf, Tobias Zeus, Ralf Westenfeld, Malte Kelm, Patrick Horn
BACKGROUND: The safety and efficacy of deep sedation (DS) in MitraClip® procedures have been shown previously. However, clinical experience demonstrates that in some patients DS is difficult to achieve. We hypothesize that some patient characteristics can predict difficult DS. METHODS: We prospectively analysed 69 patients undergoing MitraClip® procedures using DS. Application of DS was graded as simple (group 1) or difficult (group 2) depending on a cumulative score based on one point for each of the following criteria: decrease in oxygen saturation, retention of carbon dioxide, disruptive body movements, and the need for catecholamines...
2018: PloS One
https://www.readbyqxmd.com/read/29302939/transcatheter-aortic-valve-implantation-in-high-risk-inoperable-patients-repositionable-versus-non-repositionable-self-expanding-valve
#17
Verena Veulemans, Dagmar B Sötemann, Laura Kleinebrecht, Stefanie Keymel, Christian Jung, Tobias Zeus, Malte Kelm, Ralf Westenfeld
BACKGROUND: Although next-generation cardiac prostheses have shown favorable results in transcatheter aortic valve implantation (TAVI), these have mostly been documented in intermediate-risk patients. Whether this could be translated to high-risk patients is not known. Hence, the safety and clinical performance of the new, repositionable CoreValve Evolut R-System (ERS) was evaluated by comparison with a non-repositionable CoreValve-System (CVS), in 96 high-risk/inoperable (HRI) patients...
July 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29301732/gastrointestinal-lymphomas-french-intergroup-clinical-practice-recommendations-for-diagnosis-treatment-and-follow-up-snfge-ffcd-gercor-unicancer-sfcd-sfed-sfro-sfh
#18
REVIEW
Tamara Matysiak-Budnik, Bettina Fabiani, Christophe Hennequin, Catherine Thieblemont, Georgia Malamut, Guillaume Cadiot, Olivier Bouché, Agnès Ruskoné-Fourmestraux
INTRODUCTION: This document is a summary of the French Intergroup guidelines on the management of gastro-intestinal lymphomas, available on the web-site of the French Society of Gastroenterology, SNFGE (www.tncd.org), updated in September 2017. METHODS: This collaborative work was realised under the auspices of several French medical societies and involved clinicians with specific expertise in the field of gastrointestinal lymphomas, including gastroenterologists, haematologists, pathologists, and radiation oncologist, representing the major French or European clinical trial groups...
December 18, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29297564/oral-nodular-lesions-in-patients-with-sj%C3%A3-gren-s-syndrome-unusual-oral-implications-of-a-systemic-disorder
#19
Juliana Barchelli Pinheiro, Camila Tirapelli, Claudia Helena Lovato da Silva, Marilena Chinali Komesu, Flávio Calil Petean, Paulo Louzada Junior, Jorge Esquiche León, Ana Carolina Fragoso Motta
Sjögren's syndrome (SS) is a systemic chronic autoimmune disorder affecting the lacrimal and salivary glands. SS may manifest as primary SS (pSS) or secondary SS (sSS), the latter occurring in the context of another autoimmune disorder. In both cases, the dry eyes and mouth affect the patient's quality of life. Late complications may include blindness, dental tissue destruction, oral candidiasis and lymphoma. This paper reports two cases of SS, each of them presenting unusual oral nodular lesion diagnosed as relapsed MALT lymphoma and mucocele...
May 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29296236/combined-microrna-and-mrna-microfluidic-taqman-array-cards-for-the-diagnosis-of-malignancy-of-multiple-types-of-pancreatico-biliary-tumors-in-fine-needle-aspiration-material
#20
Thomas M Gress, Ludwig Lausser, Lyn-Rouven Schirra, Lisa Ortmüller, Ramona Diels, Bo Kong, Christoph W Michalski, Thilo Hackert, Oliver Strobel, Nathalia A Giese, Miriam Schenk, Rita T Lawlor, Aldo Scarpa, Hans A Kestler, Malte Buchholz
Pancreatic ductal adenocarcinoma (PDAC) continues to carry the lowest survival rates among all solid tumors. A marked resistance against available therapies, late clinical presentation and insufficient means for early diagnosis contribute to the dismal prognosis. Novel biomarkers are thus required to aid treatment decisions and improve patient outcomes. We describe here a multi-omics molecular platform that allows for the first time to simultaneously analyze miRNA and mRNA expression patterns from minimal amounts of biopsy material on a single microfluidic TaqMan Array card...
December 8, 2017: Oncotarget
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