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https://www.readbyqxmd.com/read/28107054/helping-relatives-survive-and-reproduce-inclusive-fitness-and-reproductive-value-in-brood-parasitism
#1
Malte Andersson
Costly help can raise a relative's reproduction, survival, and reproductive value and increase the inclusive fitness of the donor of help. Donor fitness is explored here in conspecific brood parasitism. In this alternative reproductive tactic, some females, "parasites," lay eggs in nests of other females of the same species, "hosts," suppliers of help that alone take care of the offspring. Modeling shows that hosts can gain inclusive fitness if parasitized by relatives whose reproduction or survival is thereby increased...
February 2017: American Naturalist
https://www.readbyqxmd.com/read/28107011/delocalization-of-coherent-triplet-excitons-in-linear-rigid-rod-conjugated-oligomers
#2
Christian Hintze, Patrick Korf, Frank Degen, Friederike Schütze, Stefan Mecking, Ulrich E Steiner, Malte Drescher
In this work, the triplet state delocalization in a series of monodisperse oligo(p-phenyleneethynylene)s (OPEs) is studied by pulsed electron paramagnetic resonance (EPR) and pulsed electron nuclear double resonance (ENDOR) determining zero-field splitting, optical spin polarization, and proton hyperfine couplings. Neither the zero-field splitting parameters nor the optical spin polarization change significantly with OPE chain length, in contrast to the hyperfine coupling constants, which showed a systematic decrease with chain length n according to a 2/(1+n) decay law...
January 20, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28106325/a-pde6%C3%AE-kras-inhibitor-chemotype-with-up-to-seven-h-bonds-and-picomolar-affinity-that-prevents-efficient-inhibitor-release-by-arl2
#3
Pablo Martín-Gago, Eyad K Fansa, Christian H Klein, Sandip Murarka, Petra Janning, Marc Schürmann, Malte Metz, Shehab Ismail, Carsten Schultz-Fademrecht, Matthias Baumann, Philippe I H Bastiaens, Alfred Wittinghofer, Herbert Waldmann
Small-molecule inhibition of the interaction between the KRas oncoprotein and the chaperone PDE6δ impairs KRas spatial organization and signaling in cells. However, despite potent binding in vitro (KD <10 nm), interference with Ras signaling and growth inhibition require 5-20 μm compound concentrations. We demonstrate that these findings can be explained by fast release of high-affinity inhibitors from PDE6δ by the release factor Arl2. This limitation is overcome by novel highly selective inhibitors that bind to PDE6δ with up to 7 hydrogen bonds, resulting in picomolar affinity...
January 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28106268/innate-immune-defense-in-the-inner-ear-mucines-are-expressed-by-the-human-endolymphatic-sac
#4
Martin N Møller, Svend Kirkeby, Per Cayé-Thomasen
The human endolymphatic sac has been shown recently to have immunological capacities and has thus been proposed as the main entity protecting the inner ear from pathogen invasion, equivalent to mucosa-associated lymphoid tissue (MALT). Although the sac expresses molecules of the innate immune system, the potential expression of members of the important mucin family has not been detailed. Thus, this paper explores endolymphatic sac expression of a number of mucins and mucin precursors. Twelve fresh tissue samples from the human endolymphatic sac were obtained during translabyrinthine surgery...
February 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28105888/treatment-with-activated-carbon-and-other-adsorbents-as-an-effective-method-for-removal-of-volatile-compounds-in-agricultural-distillates
#5
Maria Balcerek, Katarzyna Pielech-Przybylska, Piotr Patelski, Urszula Dziekońska-Kubczak, Tomaš Jusel
This study investigates the effect of treatment with activated carbon and other adsorbents on the chemical composition and organoleptics of a barley malt-based agricultural distillate. Contact with activated carbon is one of the methods by which the quality of raw distillates and spirit beverages can be improved. Samples placed in contact with 1 g activated carbon (SpiritFerm) per 100 ml distillate with ethanol content of 50% v v(-1) for 1 h showed the largest reductions in the concentrations of most volatile compounds (aldehydes, alcohols, esters)...
January 20, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28105686/visual-tactile-processing-in-primary-somatosensory-cortex-emerges-before-cross-modal-experience
#6
Malte Bieler, Kay Sieben, Sandra Schildt, Brigitte Röder, Ileana L Hanganu-Opatz
The presumptive unisensory neocortical areas process multisensory information by oscillatory entrainment of neuronal networks via direct cortico-cortical projections. While neonatal unimodal experience has been identified as necessary for setting up the neuronal networks of multisensory processing, it is still unclear whether early cross-modal experience equally controls the ontogeny of multisensory processing. Here, we assess the development of visual-somatosensory interactions and their anatomical substrate by performing extracellular recordings of network activity in primary sensory cortices in vivo and assessing the cortico-cortical connectivity in pigmented rats...
January 20, 2017: Synapse
https://www.readbyqxmd.com/read/28102341/lasing-in-live-mitotic-and-non-phagocytic-cells-by-efficient-delivery-of-microresonators
#7
Marcel Schubert, Klara Volckaert, Markus Karl, Andrew Morton, Philipp Liehm, Gareth B Miles, Simon J Powis, Malte C Gather
Reliable methods to individually track large numbers of cells in real time are urgently needed to advance our understanding of important biological processes like cancer metastasis, neuronal network development and wound healing. It has recently been suggested to introduce microscopic whispering gallery mode lasers into the cytoplasm of cells and to use their characteristic, size-dependent emission spectrum as optical barcode but so far there is no evidence that this approach is generally applicable. Here, we describe a method that drastically improves intracellular delivery of resonators for several cell types, including mitotic and non-phagocytic cells...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28094798/stable-isotopes-in-the-atmospheric-marine-boundary-layer-water-vapour-over-the-atlantic-ocean-2012-2015
#8
Marion Benetti, Hans Christian Steen-Larsen, Gilles Reverdin, Árný Erla Sveinbjörnsdóttir, Giovanni Aloisi, Max B Berkelhammer, Bernard Bourlès, Denis Bourras, Gaëlle de Coetlogon, Ann Cosgrove, Anne-Katrine Faber, Jacques Grelet, Steffen Bo Hansen, Rod Johnson, Hervé Legoff, Nicolas Martin, Andrew J Peters, Trevor James Popp, Thierry Reynaud, Malte Winther
The water vapour isotopic composition ((1)H2(16)O, H2(18)O and (1)H(2)H(16)O) of the Atlantic marine boundary layer has been measured from 5 research vessels between 2012 and 2015. Using laser spectroscopy analysers, measurements have been carried out continuously on samples collected 10-20 meter above sea level. All the datasets have been carefully calibrated against the international VSMOW-SLAP scale following the same protocol to build a homogeneous dataset covering the Atlantic Ocean between 4°S to 63°N...
January 17, 2017: Scientific Data
https://www.readbyqxmd.com/read/28094784/targeted-dna-sequencing-and-in-situ-mutation-analysis-using-mobile-phone-microscopy
#9
Malte Kühnemund, Qingshan Wei, Evangelia Darai, Yingjie Wang, Iván Hernández-Neuta, Zhao Yang, Derek Tseng, Annika Ahlford, Lucy Mathot, Tobias Sjöblom, Aydogan Ozcan, Mats Nilsson
Molecular diagnostics is typically outsourced to well-equipped centralized laboratories, often far from the patient. We developed molecular assays and portable optical imaging designs that permit on-site diagnostics with a cost-effective mobile-phone-based multimodal microscope. We demonstrate that targeted next-generation DNA sequencing reactions and in situ point mutation detection assays in preserved tumour samples can be imaged and analysed using mobile phone microscopy, achieving a new milestone for tele-medicine technologies...
January 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28089436/the-significance-of-histologic-examination-of-gastrectomy-specimens-a-clinicopathologic-study-of-511-cases
#10
Pavel Kopach, Elizabeth M Genega, Sajani N Shah, Julie J Kim, Yvelisse Suarez
BACKGROUND: Sleeve gastrectomy (SG) is quickly becoming the preferred procedure for bariatric surgery. According to the American Society for Metabolic and Bariatric Surgery guidelines, routine preoperative upper gastrointestinal endoscopies are not recommended universally for bariatric surgery. Some studies have shown that the histologic examination of SG specimens is insignificant and not a cost-effective practice. However, some speculate SG examination may unveil pertinent findings and prevent further progression of precursor lesions...
November 15, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28089147/sequent-please-vs-pantera-lux-drug-coated-balloon-angioplasty-in-real-life-results-from-the-d%C3%A3-sseldorf-dcb-registry
#11
Athena Assadi-Schmidt, Annemarie Mohring, Eva Liebsch, Lisa Dannenberg, Alina Achilles, Martin Pöhl, Shazia Afzal, Verena Veulemans, Patrick Horn, Roberto Sansone, Florian Bönner, Bodo Levkau, Malte Kelm, Tobias Zeus, Amin Polzin
BACKGROUND: In-stent restenosis (ISR) is still a major concern in interventional cardiology. Drug coated balloon (DCB) angioplasty has been shown to be a promising option in treatment of ISR. However heterogeneity of different DCBs in suppression of neointimal growth has been described in a porcine model of coronary ISR. Therefore, in this registry analysis, we compared two frequently used paclitaxel eluting DCBs, the SeQuent Please and the Pantera Lux DCB. METHODS: 571 patients were treated with DCB angioplasty at the Heinrich-Heine University Düsseldorf between 2009 and 2012...
December 13, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28088607/transcatheter-aortic-valve-implantation-leads-to-a-restoration-of-von-willebrand-factor-vwf-abnormalities-in-patients-with-severe-aortic-stenosis-incidence-and-relevance-of-clinical-and-subclinical-vwf-dysfunction-in-patients-undergoing-transfemoral-tavi
#12
Alexander Sedaghat, Hannah Kulka, Jan-Malte Sinning, Nora Falkenberg, Julia Driesen, Barbara Preisler, Christoph Hammerstingl, Georg Nickenig, Bernd Pötzsch, Johannes Oldenburg, Hans-Jörg Hertfelder, Nikos Werner
BACKGROUND: In this study, we sought to analyze the incidence and relevance of von Willebrand factor (VWF) abnormalities in patients undergoing transcatheter aortic valve implantation (TAVI), especially on perioperative bleeding. Furthermore, we hypothesized that, similar to aortic valve surgery, TAVI results in a restoration of VWF abnormalities. METHODS AND RESULTS: We performed a prospective analysis of periinterventional VWF parameters in 74 patients (80±7years, female in 37...
January 7, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28088367/assignment-of-c1q-binding-hla-antibodies-as-unacceptable-hla-antigens-avoids-positive-cdc-crossmatches-prior-to-transplantation-of-deceased-donor-organs
#13
David Juhl, Matthias Marget, Michael Hallensleben, Siegfried Görg, Malte Ziemann
Soon, a virtual crossmatch shall replace the complement-dependent cytotoxicity (CDC) allocation crossmatch in the Eurotransplant region. To prevent positive CDC-crossmatches in the recipient centre, careful definition of unacceptable antigens is necessary. For highly sensitized patients, this is difficult by CDC alone. Assignment of all antibodies detected by sensitive assays, however, could prevent organ allocation. To assess the usefulness of the Luminex C1q-assay to prevent positive CDC-crossmatches, all CDC-crossmatches performed prior to deceased kidney transplantation in a 16-month-period were reviewed...
January 11, 2017: Transplant Immunology
https://www.readbyqxmd.com/read/28087997/experience-in-action-moderating-care-in-web-based-patient-feedback
#14
Malte Ziewitz
What does it take to mobilise experiences of care and make them useful for improving services? This article draws on ethnographic fieldwork with a UK-based patient feedback website to develop a critical perspective on patient experience as a contingent accomplishment and a focal point for eliciting, provoking, and respecifying relations of accountability. Following a single posting from the moderation room back to the author and into the wards and offices of the hospital, I show how moderators, carers, and clinical staff respond to and act upon a seemingly stable experience...
December 21, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/28087736/imputation-of-orofacial-clefting-data-identifies-novel-risk-loci-and-sheds-light-on-the-genetic-background-of-cleft-lip-%C3%A2-cleft-palate-and-cleft-palate-only
#15
Kerstin U Ludwig, Anne C Böhmer, John Bowes, Miloš Nikolić, Nina Ishorst, Niki Wyatt, Nigel L Hammond, Lina Gölz, Frederic Thieme, Sandra Barth, Hannah Schuenke, Johanna Klamt, Malte Spielmann, Khalid Aldhorae, Augusto Rojas-Martinez, Markus M Nöthen, Alvaro Rada-Iglesias, Michael J Dixon, Michael Knapp, Elisabeth Mangold
Nonsyndromic cleft lip with or without cleft palate (nsCL/P) is among the most common human birth defects with multifactorial etiology. Here, we present results from a genome-wide imputation study of nsCL/P in which, after adding replication cohort data, four novel risk loci for nsCL/P are identified (at chromosomal regions 2p21, 14q22, 15q24 and 19p13). On a systematic level, we show that the association signals within this high-density dataset are enriched in functionally-relevant genomic regions that are active in both human neural crest cells (hNCC) and mouse embryonic craniofacial tissue...
January 13, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28081104/intracavity-stretcher-for-chirped-pulse-amplification-in-high-power-laser-systems
#16
Hartmut Liebetrau, Marco Hornung, Sebastian Keppler, Marco Hellwing, Alexander Kessler, Frank Schorcht, Joachim Hein, Malte C Kaluza
We present pulse stretching with an intracavity Offner-type pulse stretcher applied to a high-energy, short-pulse laser system. The compact intracavity design, offering a tunable stretching factor, allows the pulses to be stretched to several nanoseconds and, at the same time, to be amplified to 100 μJ. The stretched pulses have been further amplified with the high-power laser system Polaris and have been recompressed to durations as short as 102 fs, reaching peak powers of 100 TW. Furthermore, the temporal intensity contrast is investigated and compared to the formerly used stretcher setup...
January 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28078126/gastrointestinal-lymphoma-in-western-algeria-pattern-of-distribution-and-histological-subtypes-retrospective-study
#17
Soumia Zeggai, Noria Harir, Abdenacer Tou, Miloud Medjamia, Khaira Guenaoui
BACKGROUND: Primary gastrointestinal (GI) lymphomas (GIL) are uncommon diseases that can involve the whole GI tract. Considerable variation exists in the literature with respect to incidence of the various histological subtypes and sites of involvement. This study was undertaken to establish the anatomic distribution, histological subtypes and sites of GI lymphomas of patients from Western Algeria. METHODS: The case records of 58 consecutive patients with GIL diagnosed at the Pathologies Departments of Algerian west region (the Military Hospital of Oran city and the Central University Hospital of Sidi Bel Abbes city) from January 2006 to December 2013 were retrospectively evaluated for epidemiology and histopathology report...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28077625/radiotherapy-for-localized-gastric-mucosa-associated-lymphoid-tissue-lymphoma-long-term-outcomes-over-10-years
#18
Yu Ohkubo, Yoshihiro Saito, Hiroki Ushijima, Masahiro Onishi, Tomoko Kazumoto, Jun-Ichi Saitoh, Nobuko Kubota, Hirofumi Kobayashi, Nobuo Maseki, Yu Nishimura, Masafumi Kurosumi
This study aimed to assess the long-term outcomes of radiotherapy in patients with localized gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Twenty-seven patients with Stage I gastric MALT lymphoma were treated with radiotherapy from 1999 to 2010. The median age was 65 years (range: 31-84). Fifteen patients were Helicobacter pylori-negative. Thirteen patients were treated with definitive radiotherapy alone. The other 14 patients who had refractory or residual disease following a prior treatment received salvage radiotherapy...
January 10, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28077562/sensitive-and-inexpensive-digital-dna-analysis-by-microfluidic-enrichment-of-rolling-circle-amplified-single-molecules
#19
Malte Kühnemund, Iván Hernández-Neuta, Mohd Istiaq Sharif, Matteo Cornaglia, Martin A M Gijs, Mats Nilsson
Single molecule quantification assays provide the ultimate sensitivity and precision for molecular analysis. However, most digital analysis techniques, i.e. droplet PCR, require sophisticated and expensive instrumentation for molecule compartmentalization, amplification and analysis. Rolling circle amplification (RCA) provides a simpler means for digital analysis. Nevertheless, the sensitivity of RCA assays has until now been limited by inefficient detection methods. We have developed a simple microfluidic strategy for enrichment of RCA products into a single field of view of a low magnification fluorescent sensor, enabling ultra-sensitive digital quantification of nucleic acids over a dynamic range from 1...
January 10, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28076871/intraoperative-hypotonie-pathophysiologie-und-klinische-relevanz
#20
Malte Book, Florian Jelschen, Andreas Weyland
No abstract text is available yet for this article.
January 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
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