keyword
MENU ▼
Read by QxMD icon Read
search

integrated care pathways

keyword
https://www.readbyqxmd.com/read/29344898/methods-for-high-throughput-drug-combination-screening-and-synergy-scoring
#1
Liye He, Evgeny Kulesskiy, Jani Saarela, Laura Turunen, Krister Wennerberg, Tero Aittokallio, Jing Tang
Gene products or pathways that are aberrantly activated in cancer but not in normal tissue hold great promises for being effective and safe anticancer therapeutic targets. Many targeted drugs have entered clinical trials but so far showed limited efficacy mostly due to variability in treatment responses and often rapidly emerging resistance. Toward more effective treatment options, we will need multi-targeted drugs or drug combinations, which selectively inhibit the viability and growth of cancer cells and block distinct escape mechanisms for the cells to become resistant...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29344895/bioinformatics-approaches-to-predict-drug-responses-from-genomic-sequencing
#2
Neel S Madhukar, Olivier Elemento
Fulfilling the promises of precision medicine will depend on our ability to create patient-specific treatment regimens. Therefore, being able to translate genomic sequencing into predicting how a patient will respond to a given drug is critical. In this chapter, we review common bioinformatics approaches that aim to use sequencing data to predict sample-specific drug susceptibility. First, we explain the importance of customized drug regimens to the future of medical care. Second, we discuss the different public databases and community efforts that can be leveraged to develop new methods for identifying new predictive biomarkers...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29338778/increased-whole-blood-ffa2-gpr43-receptor-expression-is-associated-with-increased-30-day-survival-in-patients-with-sepsis
#3
Zyad J Carr, Andry Van De Louw, Graham Fehr, Jialiu D Li, Allen Kunselman, Victor Ruiz-Velasco
OBJECTIVE: Sepsis is a condition associated with a dysregulated inflammatory response to infection with significant morbidity. Recent advances have elucidated the vital role that the short chain fatty acid glycoprotein receptor 43 (FFA2/GPR43) plays in inflammatory and immunomodulatory pathways. We hypothesized that elevated whole blood GPR43 RNA expression would be associated with increased 30-day survival in patients admitted with sepsis. Patients (n = 93) admitted to the intensive care unit with the diagnosis of sepsis underwent quantitative real time PCR within 48 h of intensive care unit admission...
January 16, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29336644/evidence-education-and-multi-disciplinary-integration-are-needed-to-embed-exercise-into-lung-cancer-clinical-care-a-qualitative-study-involving-physiotherapists
#4
Catherine L Granger, Selina M Parry, Linda Denehy, Louisa Remedios
AIMS: To explore physiotherapists perceptions regarding barriers and enablers to embedding exercise into routine lung cancer clinical care. DESIGN: Qualitative study (content analysis). Eight physiotherapists working in the area of lung cancer at five hospitals participated. The focus group was conducted, transcribed verbatim and independently crosschecked. Thematic analysis was utilized. RESULTS: The data generated four major themes: evidence justifying exercise; staffing and services; maximising the efficacy of interventions; and hospital culture...
January 16, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29334351/integrating-third-party-telehealth-records-with-the-general-practice-electronic-medical-record-system-a-solution
#5
Mary Paterson, Alison McAulay, Brian McKinstry
BACKGROUND: The implementation of telemonitoring at scale has been less successful than anticipated, often hindered by clinicians' perceived increase in workload. One important factor has been the lack of integration of patient generated data (PGD) with the electronic medical record (EMR). Clinicians have had problems accessing PGD on telehealth systems especially in patient consultations in primary care. OBJECTIVE: To design a method to produce a report of PGD that is available to clinicians through their routine EMR system...
November 17, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/29332973/metabologenomics-of-phaeochromocytoma-and-paraganglioma-an-integrated-approach-for-personalised-biochemical-and-genetic-testing
#6
REVIEW
Graeme Eisenhofer, Barbara Klink, Susan Richter, Jacques Wm Lenders, Mercedes Robledo
The tremendous advances over the past two decades in both clinical genetics and biochemical testing of chromaffin cell tumours have led to new considerations about how these aspects of laboratory medicine can be integrated to improve diagnosis and management of affected patients. With germline mutations in 15 genes now identified to be responsible for over a third of all cases of phaeochromocytomas and paragangliomas, these tumours are recognised to have one of the richest hereditary backgrounds among all neoplasms...
April 2017: Clinical Biochemist. Reviews
https://www.readbyqxmd.com/read/29329571/environmental-exposures-and-fetal-growth-the-haifa-pregnancy-cohort-study
#7
Rachel Golan, Itai Kloog, Ronit Almog, Anat Gesser-Edelsburg, Maya Negev, Maya Jolles, Varda Shalev, Vered H Eisenberg, Gideon Koren, Wiessam Abu Ahmad, Hagai Levine
BACKGROUND: The developing fetus is susceptible to environmental insults. Studying the effects of environmental exposures on fetal growth is essential for understanding the causal pathway between prenatal exposures and pregnancy outcomes. Here we describe the Haifa Pregnancy Cohort Study (HPCS) and discuss challenges and opportunities in applying "big data" paradigm. METHODS: Maccabi Healthcare Services (MHS), is the second largest Israeli health maintenance organization (HMO) providing care services to two million beneficiaries...
January 12, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29329310/medication-discrepancies-across-multiple-care-transitions-a-retrospective-longitudinal-cohort-study-in-italy
#8
Marco Bonaudo, Maria Martorana, Valerio Dimonte, Alessandra D'Alfonso, Giulio Fornero, Gianfranco Politano, Maria Michela Gianino
PURPOSE: Medication discrepancies are defined as unexplained differences among regimens across different sites of care. The problem of medication discrepancies that occur during the entire care pathway from hospital admission to a local care setting discharge (namely all types of settings dedicated to formal care other than hospitals) has received little attention in the medical literature. The present study aims to (1) determine the prevalence of medication discrepancies that occur during the entire care pathway from hospital admission to local care setting discharge, (2) describe the discrepancy and medication type, and (3) identify potential risk factors for experiencing medication discrepancies in patient care transitions...
2018: PloS One
https://www.readbyqxmd.com/read/29321008/effects-of-a-culturally-specific-tobacco-cessation-intervention-among-african-american-quitline-enrollees-a-randomized-controlled-trial
#9
Monica Webb Hooper, Kelly Carpenter, Michael Payne, Ken Resnicow
BACKGROUND: African Americans suffer disproportionately from tobacco-related illness and have more difficulty quitting smoking than other racial/ethnic groups. Previous research indicates that African American treatment-seekers are high utilizers of tobacco quitlines, yet cessation rates via quitlines are lower relative to whites. The goal of the present study is to test the effectiveness of adding a culturally specific, video-based, adjunct to standard quitline care. It is hypothesized that the integration of an evidence-based intervention (Pathways to Freedom: Leading the Way to a Smoke-Free Community©; PTF) into quitline services will increase cessation and treatment engagement compared to control conditions, and that effects will be moderated by sociocultural factors (e...
January 10, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29310993/consensus-methodology-to-determine-minor-ailments-appropriate-to-be-directed-for-management-within-community-pharmacy
#10
Hamde Nazar, Zachariah Nazar, Andre Yeung, Mike Maguire, Alex Connelly, Sarah P Slight
BACKGROUND: National Health Service (NHS) 111, a medical helpline for urgent care used within the England and Scotland, receives significant numbers of patient calls yearly for a range of clinical conditions. Some are considered high acuity and mainly directed to urgent and emergency care. Low acuity conditions are also directed to these costly, overburdened services. Community pharmacy is a recognised setting for effective low acuity condition management and could offer an alternative...
January 4, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29310566/analysis-of-oxidative-stress-related-markers-in-critically-ill-polytrauma-patients-an-observational-prospective-single-center-study
#11
Mihai Sandesc, Alexandru Florin Rogobete, Ovidiu Horea Bedreag, Anca Dinu, Marius Papurica, Carmen Alina Cradigati, Mirela Sarandan, Sonia Elena Popovici, Lavinia Melania Bratu, Tiberiu Bratu, Adrian Tudor Stan, Dorel Sandesc
Critically ill polytrauma patients have increased production of free radicals (FRs) and consequent alterations in biochemical pathways, as well as disruption of cellular integrity, due to increased lipid peroxidation. The aim of this study was to investigate several biomarkers associated with increased oxidative stress in critically ill polytrauma patients, and to evaluate the effect of antioxidant treatment on the clinical outcome in these patients. A total of 67 polytrauma patients from an intensive care unit met the selection criteria...
January 9, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29307764/predictive-model-integrating-dynamic-parameters-for-massive-blood-transfusion-in-major-trauma-patients-the-dynamic-mbt-score
#12
Chun Tat Lui, Oi Fung Wong, Kwok Leung Tsui, Chak Wah Kam, Siu Man Li, Mina Cheng, Ka Kit Gilberto Leung
BACKGROUND: Currently existing predictive models for massive blood transfusion in major trauma patients had limitations for sequential evaluation of patients and lack of dynamic parameters. OBJECTIVE: To establish a predictive model for predicting the need of massive blood transfusion major trauma patients, integrating dynamic parameters. DESIGN: Multi-center retrospective cohort study. SETTING: Four designated trauma centers in Hong Kong...
January 4, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29307411/food-allergy-and-omics
#13
REVIEW
Gopal Krishna Dhondalay, Efren Rael, Swati Acharya, Wenming Zhang, Vanitha Sampath, Stephen J Galli, Robert Tibshirani, Scott D Boyd, Holden Maecker, Kari Christine Nadeau, Sandra Andorf
Food allergy (FA) prevalence has been increasing over the last few decades and is now a global health concern. Current diagnostic methods for FA result in a high number of false-positive results, and the standard of care is either allergen avoidance or use of epinephrine on accidental exposure, although currently with no other approved treatments. The increasing prevalence of FA, lack of robust biomarkers, and inadequate treatments warrants further research into the mechanism underlying food allergies. Recent technological advances have made it possible to move beyond traditional biological techniques to more sophisticated high-throughput approaches...
January 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29304866/update-on-the-integrated-nutrition-pathway-for-acute-care-inpac-post-implementation-tailoring-and-toolkit-to-support-practice-improvements
#14
Heather Keller, Celia Laur, Marlis Atkins, Paule Bernier, Donna Butterworth, Bridget Davidson, Brenda Hotson, Roseann Nasser, Manon Laporte, Chelsa Marcell, Sumantra Ray, Jack Bell
The Integrated Nutrition Pathway for Acute Care (INPAC) is an evidence and consensus based pathway developed to guide health care professionals in the prevention, detection, and treatment of malnutrition in medical and surgical patients. From 2015 to 2017, the More-2-Eat implementation project (M2E) used a participatory action research approach to determine the feasibility, and evaluate the implementation of INPAC in 5 hospital units across Canada. Based on the findings of M2E and consensus with M2E stakeholders, updates have been made to INPAC to enhance feasibility in Canadian hospitals...
January 5, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29300976/integrating-new-approaches-to-atrial-fibrillation-management-the-6th-afnet-ehra-consensus-conference
#15
Dipak Kotecha, Günter Breithardt, A John Camm, Gregory Y H Lip, Ulrich Schotten, Anders Ahlsson, David Arnar, Dan Atar, Angelo Auricchio, Jeroen Bax, Stefano Benussi, Carina Blomstrom-Lundqvist, Martin Borggrefe, Giuseppe Boriani, Axel Brandes, Hugh Calkins, Barbara Casadei, Manuel Castellá, Winnie Chua, Harry Crijns, Dobromir Dobrev, Larissa Fabritz, Martin Feuring, Ben Freedman, Andrea Gerth, Andreas Goette, Eduard Guasch, Doreen Haase, Stephane Hatem, Karl Georg Haeusler, Hein Heidbuchel, Jeroen Hendriks, Craig Hunter, Stefan Kääb, Stefanie Kespohl, Ulf Landmesser, Deirdre A Lane, Thorsten Lewalter, Lluís Mont, Michael Nabauer, Jens C Nielsen, Michael Oeff, Jonas Oldgren, Ali Oto, Laurent Pison, Tatjana Potpara, Ursula Ravens, Isabelle Richard-Lordereau, Michiel Rienstra, Irina Savelieva, Renate Schnabel, Moritz F Sinner, Philipp Sommer, Sakis Themistoclakis, Isabelle C Van Gelder, Panagiotis E Vardas, Atul Verma, Reza Wakili, Evelyn Weber, David Werring, Stephan Willems, André Ziegler, Gerhard Hindricks, Paulus Kirchhof
There are major challenges ahead for clinicians treating patients with atrial fibrillation (AF). The population with AF is expected to expand considerably and yet, apart from anticoagulation, therapies used in AF have not been shown to consistently impact on mortality or reduce adverse cardiovascular events. New approaches to AF management, including the use of novel technologies and structured, integrated care, have the potential to enhance clinical phenotyping or result in better treatment selection and stratified therapy...
January 2, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29298363/dietary-and-nutrition-recommendations-in-pediatric-primary-care-a-call-to-action
#16
Sayward E Harrison, Deborah Greenhouse
Rapid increases in childhood obesity reflect widespread changes in diet and physical activity, which are of significant concern because obesity increases a child's risk for negative health outcomes and frequently creates a pathway to adult obesity. Diet and nutrition play a key role in maintaining energy balance and preventing weight gain; therefore, they are obvious targets for obesity prevention efforts. Primary care providers are in an optimal position to convey messages about healthy eating to children and families, and specific guidelines exist for how to incorporate diet and nutrition prevention into primary care...
January 2018: Southern Medical Journal
https://www.readbyqxmd.com/read/29297334/the-hub-and-spoke-organization-design-revisited-a-lifeline-for-rural-hospitals
#17
James K Elrod, John L Fortenberry
BACKGROUND: Characterized by declining populations, high poverty, reduced employment opportunities, and high numbers of uninsured residents, rural communities pose significant challenges for healthcare providers desirous of addressing these medically underserved areas. Such difficult environments, in fact, have forced the closure of many rural hospitals across America, with scores facing the same threat, compelling intensive efforts to identify pathways which will yield an improved future...
December 13, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29277953/emergent-leadership-among-tenants-with-psychiatric-disabilities-living-in-supported-housing
#18
Myra Piat, Judith Sabetti, Deborah Padgett
The overall aim of this study was to explore the experiences of people with psychiatric disabilities living as tenants in independent, supported apartments for the first time. Supported housing provides an alternative to structured, custodial housing models, such as foster homes, or board-and-care homes, for clients in public mental health systems. This article reports findings on how leadership emerged among tenants after making the transition from custodial to supported housing. Semi-structured interviews were conducted with tenants (n = 24) and included questions on their housing history, current living situation, relationships with staff, participation, and understanding or experience of leadership...
December 25, 2017: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29277456/stress-autonomic-imbalance-and-the-prediction-of-metabolic-risk-a-model-and-a-proposal-for-research
#19
REVIEW
Lawson Wulsin, James Herman, Julian F Thayer
BACKGROUND: Devising novel prevention strategies for metabolic disorders will depend in part on the careful elucidation of the common pathways for developing metabolic risks. The neurovisceral integration model has proposed that autonomic imbalance plays an important role in the pathway from acute and chronic stress to cardiovascular disease. Though generally overlooked by clinicians, autonomic imbalance (sympathetic overactivity and/or parasympathetic underactivity) can be measured and modified by methods that are available in primary care...
December 22, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29247265/end-of-life-care-pathway-of-head-and-neck-cancer-patients-single-institution-experience
#20
T Heinonen, V Loimu, K Saarilahti, T Saarto, A Mäkitie
BACKGROUND: Studies on palliative care of head and neck cancer (HNC) patients are scarce although the affected patient population is quite large. OBJECTIVE: To evaluate the role of a specialised palliative-care pathway of HNC patients. PATIENTS AND METHODS: Data on all HNC patients who were treated at the Helsinki University Hospital Palliative Care Center during 1 year were retrospectively reviewed. The analysis comprised 60 patients (49 males; mean age 67 years; range 28-88)...
December 15, 2017: European Archives of Oto-rhino-laryngology
keyword
keyword
15666
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"