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Dihydromyricetin

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https://www.readbyqxmd.com/read/28534405/tissue-distribution-excretion-and-metabolic-profile-of-dihydromyricetin-a-flavonoid-from-vine-tea-ampelopsis-grossedentata-after-oral-administration-in-rats
#1
Li Fan, Qing Tong, Weiwei Dong, Guangjie Yang, Xiaolong Hou, Wei Xiong, Chunyang Shi, Jianguo Fang, Wenqing Wang
Dihydromyricetin (DMY), a flavanonol compound found as the most abundant and bioactive constituent in vine tea (Ampelopsis grossedentata), possesses numerous biological activities. In the present study, a HPLC-MS/MS method for the determination of DMY in tissues, urine and feces was developed and applied to the tissue distribution and excretion study after oral administration in rats, and the metabolic profile of DMY was further investigated using UPLC-QTOF-MS. The results indicated that DMY could be distributed rapidly in various tissues and highly in gastrointestinal tract...
May 23, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28500865/dihydromyricetin-ameliorates-atherosclerosis-in-ldl-receptor-deficient-mice
#2
Ting Ting Liu, Yi Zeng, Kun Tang, XueMeng Chen, Wei Zhang, Xiao Le Xu
BACKGROUND AND AIMS: Dihydromyricetin, the most abundant flavonoid in Ampelopsis grossedentata, exerts numerous pharmacological activities, including anti-inflammatory, antioxidant, hepatoprotective, and lipid regulatory activities; however, its protective effect against atherosclerosis remains poorly understood. The aim of the present study was to evaluate the effects of dihydromyricetin on high fat diet (HFD)-induced atherosclerosis using LDL receptor deficient (LDLr(-/-)) mice. METHODS: Blood samples were collected for determination of serum lipid profiles, oxidized LDL (ox-LDL) and pro-inflammatory cytokines...
May 5, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28490955/protection-of-oxidative-stress-induced-apoptosis-in-osteosarcoma-cells-by-dihydromyricetin-through-down-regulation-of-caspase-activation-and-up-regulation-of-bcl-2
#3
Yuming Wang, Wei Wang, Enduo Qiu
Current study was aimed to investigate the effect of dihydromyricetin on hydrogen peroxide induced oxidative stress in the osteosarcoma cells. MTT assay showed that hydrogen peroxide treatment at a concentration of 100 μM caused a significant (p < 0.005) reduction in the viability of MG63 cells. However, reduction in cell viability caused by 100 μM concentration of hydrogen peroxide was completely prevented on incubation with 30 μM dose of dihydromyricetin. Treatment with 100 μM concentration of hydrogen peroxide for 24 h led to condensation of chromatin material, rounding of cell shape and detachment of cells...
May 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28482716/dihydromyricetin-induces-apoptosis-and-cytoprotective-autophagy-through-ros-nf-%C3%AE%C2%BAb-signaling-in-human-melanoma-cells
#4
Ding-Zhou Zhou, Hai-Ying Sun, Jing-Qi Yue, Yong Peng, Yi-Ming Chen, Zhi-Jian Zhong
Dihydromyricetin (DHM), a Rattan tea extract, has recently been shown to have anti-cancer activity in mammalian cells. In the present study, we investigated the effect of DHM on human melanoma cells. Apart from induction of apoptosis, we demonstrated that DHM induced an autophagic response. Moreover, pharmacological inhibition or genetic blockade of autophagy enhanced DHM-induced cell death and apoptosis, indicating the cytoprotective role of autophagy in DHM-treated human melanoma cells. Further study suggested that the nuclear factor kappa B (NF-κB) signaling pathway was involved in DHM-induced autophagy...
May 8, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28466863/erratum-dihydromyricetin-protects-neurons-in-an-mptp-induced-model-of-parkinson-s-disease-by-suppressing-glycogen-synthase-kinase-3-beta-activity
#5
(no author information available yet)
No abstract text is available yet for this article.
May 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28436480/dihydromyricetin-induces-apoptosis-and-reverses-drug-resistance-in-ovarian-cancer-cells-by-p53-mediated-downregulation-of-survivin
#6
Yingqi Xu, Shengpeng Wang, Hon Fai Chan, Huaiwu Lu, Zhongqiu Lin, Chengwei He, Meiwan Chen
Ovarian cancer is one of the leading causes of death in gynecological malignancies, and the resistance to chemotherapeutic agents remains a major challenge to successful ovarian cancer chemotherapy. Dihydromyricetin (DHM), a natural flavonoid derived from Ampeopsis Grossdentata, has been widely applied in food industry and medicine for a long time. However, little is known about the effects of DHM on ovarian cancer and the underlying mechanisms. In this study, we demonstrated that DHM could effectively inhibit the proliferation of ovarian cancer cells and induce cell apoptosis...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28421194/dihydromyricetin-protects-against-diabetic-cardiomyopathy-in-streptozotocin-induced-diabetic-mice
#7
Bin Wu, Jie Lin, Jian Luo, Dong Han, Miaomiao Fan, Tao Guo, Ling Tao, Ming Yuan, Fu Yi
Diabetic cardiomyopathy (DCM) is an important cause of heart failure in diabetic patients. The present study sought to explore the potential effects of dihydromyricetin (DHM) on DCM and its possible mechanism. A diabetic model was induced by intraperitoneal injection of streptozotocin (STZ) in C57BL/6J mice. Two weeks after the STZ injection, mice were randomly allocated into the following 4 groups for treatment: the control group (CON), the control treated with DHM group (CON + DHM), the diabetes group (DM), and the diabetes treated with DHM group (DM + DHM)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28419832/dihydromyricetin-modulates-p62-and-autophagy-crosstalk-with-the-keap-1-nrf2-pathway-to-alleviate-ethanol-induced-hepatic-injury
#8
Ping Qiu, Yu Dong, Bo Li, Xian-Jie Kang, Chao Gu, Tao Zhu, Yun-Yun Luo, Min-Xia Pang, Wei-Feng Du, Wei-Hong Ge
Increasing evidence has demonstrated that dihydromyricetin (DMY) contains highly effective antioxidative, anti-inflammatory, anti-microbial and anti-diabetic properties. Nevertheless, the underlying hepatoprotective mechanisms of DMY have infrequently been reported thus far. In the present study, C57BL/6 mice were fed with the Lieber-DeCarli diet containing alcohol or isocaloric maltose dextrin as a control diet with or without DMY (75 and 150mg/kg/d bw) for 6 weeks. DMY significantly attenuated hepatic enzyme release, hepatic lipid peroxidation and triglyceride deposition induced by chronic alcohol exposure...
April 15, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28414055/dihydromyricetin-attenuated-ang-ii-induced-cardiac-fibroblasts-proliferation-related-to-inhibitory-of-oxidative-stress
#9
Qiuyi Song, Lulu Liu, Jin Yu, Jingyao Zhang, Mengting Xu, Linlin Sun, Huiqin Luo, Zhaosong Feng, Guoliang Meng
Dihydromyricetin (DMY) is one of the most important flavonoids in vine tea, which showed several pharmacological effects. However, information about the potential role of DMY on angiotensin II (Ang II) induced cardiac fibroblasts proliferation remains unknown. In the present study, cardiac fibroblasts isolated from neonatal Sprague-Dawley rats were pretreated with different concentrations of DMY (0-320μM) for 4h, or DMY (80μM) for different time (0-24h), followed by Ang II (100nM) stimulation for 24h, Then number of cardiac fibroblasts and content of hydroxyproline was measured...
April 13, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28400785/dihydroflavonol-4-reductase-genes-from-freesia-hybrida-play-important-and-partially-overlapping-roles-in-the-biosynthesis-of-flavonoids
#10
Yueqing Li, Xingxue Liu, Xinquan Cai, Xiaotong Shan, Ruifang Gao, Song Yang, Taotao Han, Shucai Wang, Li Wang, Xiang Gao
Dihydroflavonol-4-reductase (DFR) is a key enzyme in the reduction of dihydroflavonols to leucoanthocyanidins in both anthocyanin biosynthesis and proanthocyanidin accumulation. In many plant species, it is encoded by a gene family, however, how the different copies evolve either to function in different tissues or at different times or to specialize in the use of different but related substrates needs to be further investigated, especially in monocot plants. In this study, a total of eight putative DFR-like genes were firstly cloned from Freesia hybrida...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28393183/anti%C3%A2-inflammatory-effects-of-dihydromyricetin-in-a-mouse-model-of-asthma
#11
Bin Xu, Shuran Huang, Caiying Wang, Haitao Zhang, Shengcun Fang, Yingming Zhang
Dihydromyricetin (DHM) is a plant flavonoid and is the primary active ingredient isolated from the medicinal herb, Ampelopsis grossedentata. DHM has been shown to possess various pharmacological activities, including anti‑inflammatory effects. However, the possible role of DHM in asthma treatment remains to be elucidated. The present study aimed to investigate its anti‑inflammatory properties in mice with symptoms of allergic asthma. The C57BL/6 mice were sensitized and challenged with ovalbumin (OVA) to induce asthma...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28381351/dihydromyricetin-induces-mitochondria-mediated-apoptosis-in-hepg2-cells-through-down-regulation-of-the-akt-bad-pathway
#12
Zhuangwei Zhang, Huiqin Zhang, Shiyong Chen, Yan Xu, Anjun Yao, Qi Liao, Liyuan Han, Zuquan Zou, Xiaohong Zhang
The plant flavonol dihydromyricetin (DHM) was reported to induce apoptosis in human hepatocarcinoma HepG2 cells. This study was undertaken to elucidate the underlying molecular mechanism of action of DHM. In the study, DHM down-regulated Akt expression and its phosphorylation at Ser473, up-regulated the levels of mitochondrial proapoptotic proteins Bax and Bad, and inhibited the phosphorylation of Bad at Ser136 and Ser112. It also inhibited the expression of the antiapoptotic protein Bcl-2 and enhanced the cleavage and activation of caspase-3 as well as the degradation of its downstream target poly(ADP-ribose) polymerase...
February 2017: Nutrition Research
https://www.readbyqxmd.com/read/28363698/dihydromyricetin-prevents-obesity-induced-slow-twitch-fiber-reduction-partially-via-flcn-fnip1-ampk-pathway
#13
Qicheng Zhou, Yeyun Gu, Hedong Lang, Xiaolan Wang, Ka Chen, Xinhua Gong, Min Zhou, Li Ran, Jundong Zhu, Mantian Mi
Obesity is often accompanied by decreases in the proportion of skeletal muscle slow-twitch fibers and insulin sensitivity. Increased plasma non-esterified fatty acids (NEFA) levels are responsible for obesity-associated insulin resistance. Palmitate, one of the most elevated plasma NEFA in obesity, has been recognized as the principle inducer of insulin resistance. The present study showed that increased plasma NEFA levels were negatively linked to slow-twitch fiber proportion and insulin sensitivity, while slow-twitch fiber proportion was positively correlated to insulin sensitivity in high fat diet (HFD)-fed and ob/ob mice...
March 29, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28348066/poplar-myb115-and-myb134-transcription-factors-regulate-proanthocyanidin-synthesis-and-structure
#14
Amy Midori James, Dawei Ma, Robin Mellway, Andreas Gesell, Kazuko Yoshida, Vincent Walker, Lan Tran, Don Stewart, Michael Reichelt, Jussi Suvanto, Juha-Pekka Salminen, Jonathan Gershenzon, Armand Séguin, C Peter Constabel
The accumulation of proanthocyanidins is regulated by a complex of transcription factors composed of R2R3 MYB, basic helix-loop-helix, and WD40 proteins that activate the promoters of biosynthetic genes. In poplar (genus Populus), MYB134 is known to regulate proanthocyanidin biosynthesis by activating key flavonoid genes. Here, we characterize a second MYB regulator of proanthocyanidins, MYB115. Transgenic poplar overexpressing MYB115 showed a high-proanthocyanidin phenotype and reduced salicinoid accumulation, similar to the effects of MYB134 overexpression...
May 2017: Plant Physiology
https://www.readbyqxmd.com/read/28315000/polyphenol-metabolism-in-differently-colored-cultivars-of-red-currant-ribes-rubrum-l-through-fruit-ripening
#15
Zala Zorenc, Robert Veberic, Darinka Koron, Silvija Miosic, Olly Sanny Hutabarat, Heidi Halbwirth, Maja Mikulic-Petkovsek
Rare red currants colors caused by low anthocyanin content in the pink and a lack of anthocyanins in the white cultivar correlated with low ANS gene expression, enzyme activity, and increased sugar/acid ratios. Changes in the contents of polyphenols, sugars, and organic acids in berries of the three differently colored Ribes rubrum L. cultivars ('Jonkheer van Tets', 'Pink Champagne', and 'Zitavia') were determined by LC-MS and HPLC at 4 sampling times during the last month of fruit ripening. The activities of the main flavonoid enzymes, chalcone synthase/chalcone isomerase (CHS/CHI), flavanone 3-hydroxylase (FHT), and dihydroflavonol 4-reductase (DFR), and the expression of anthocyanidin synthase (ANS) were additionally measured...
March 17, 2017: Planta
https://www.readbyqxmd.com/read/28244316/highly-efficient-enzymatic-acylation-of-dihydromyricetin-by-the-immobilized-lipase-with-deep-eutectic-solvents-as-cosolvent
#16
Shi-Lin Cao, Xiao Deng, Pei Xu, Zi-Xuan Huang, Jian Zhou, Xue-Hui Li, Min-Hua Zong, Wen-Yong Lou
A novel deep eutectic solvent (DES)-DMSO cosolvent system has been, for the first time, successfully used as the reaction medium for the enzymatic acylation of dihydromyricetin (DMY) catalyzed by the immobilized lipase from Aspergillus niger (ANL). The cosolvent mixture, ChCl:Glycerol-DMSO (1:3, v/v) proved to be the optimal medium. With the newly developed cosolvent, the initial reaction rate of enzymatic acylation of DMY achieved 11.1 mM/h and the conversion of DMY was 91.6%. ANL@PD-MNPs is stable and recyclable in this cosolvent, offering 90% conversion rate after repeated use of 5 times...
March 7, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28240161/dihydromyricetin-reduces-tgf-%C3%AE-via-p53-activation-dependent-mechanism-in-hepatocellular-carcinoma-hepg2-cells
#17
Xiaojie Huang, Tianming Lian, Xiaoqian Guan, Bin Liu, Zeqing Song, Jingjing Zhang, Shiting Bao, Runzhi Zhu
Natural antineoplastic drug development is crucial to treatment of clinical oncology. Dihydromyricetin, a bioactive flavonoid compound was extracted from the stems and leaves of Ampelopsis grossedentata. It exhibited anticancer activity and induced apoptosis in human hepatocellular carcinoma cells according to our previous studies. In this study, we demonstrated that DHM could significantly inhibit proliferation and induce apoptosis in HepG2 cells with MTT and Flow Cytometry methods. It is very interesting that we found DHM could regulate TGF-β signal pathway and which has a crosstalk with P53, Smad3 and P-Smad2/3 proteins...
February 23, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28208574/complexation-of-phytochemicals-with-cyclodextrin-derivatives-an-insight
#18
REVIEW
Vasanti Suvarna, Parul Gujar, Manikanta Murahari
Natural compounds have been attracting huge attention because of their broad therapeutic properties with specificity in their action in human health care as functional foods, pharmaceuticals and nutraceuticals. However poor bioavailability and reduced bioactivity attributed to poor solubility and instability is the major drawback hindering the incorporation of these therapeutically potential molecules in novel drug delivery systems. Based on the findings of reported research investigations; complexation of poorly water soluble phytochemicals with cyclodextrins has emerged to be a promising approach to improve their aqueous solubility, stability, rate of dissolution and bioavailability...
April 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28114854/gastrointestinal-stability-of-dihydromyricetin-myricetin-and-myricitrin-an-in-vitro-investigation
#19
Dong Xiang, Chen-Guang Wang, Wen-Qing Wang, Chun-Yang Shi, Wei Xiong, Meng-Die Wang, Jian-Guo Fang
The gastrointestinal (GI) stability of three flavonoids, dihydromyricetin (DMY), myricetin (MYR), and myricitrin (MYT), was examined in simulated physiological fluids. Several factors that may influence the degradation rate of theses flavonoids were evaluated, including pH and the presence of pepsin and pancreatin enzymes. We found that GI stability followed the order of MYT > DMY > MYR. These flavonoids were stable in simulated gastric fluids and buffer solutions (pH 1.2), but encountered a pseudo-first-order kinetic degradation in simulated intestinal fluids and buffer solutions (pH 6...
January 23, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28092088/erratum-to-dihydromyricetin-improves-hypobaric-hypoxia-induced-memory-impairment-via-modulation-of-sirt3-signaling
#20
Peng Liu, Dan Zou, Ka Chen, Qicheng Zhou, Yanxiang Gao, Yujie Huang, Jundong Zhu, Qianyong Zhang, Mantian Mi
No abstract text is available yet for this article.
January 16, 2017: Molecular Neurobiology
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