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Dihydromyricetin

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https://www.readbyqxmd.com/read/28208574/complexation-of-phytochemicals-with-cyclodextrin-derivatives-an-insight
#1
REVIEW
Vasanti Suvarna, Parul Gujar, Manikanta Murahari
Natural compounds have been attracting huge attention because of their broad therapeutic properties with specificity in their action in human health care as functional foods, pharmaceuticals and nutraceuticals. However poor bioavailability and reduced bioactivity attributed to poor solubility and instability is the major drawback hindering the incorporation of these therapeutically potential molecules in novel drug delivery systems. Based on the findings of reported research investigations; complexation of poorly water soluble phytochemicals with cyclodextrins has emerged to be a promising approach to improve their aqueous solubility, stability, rate of dissolution and bioavailability...
February 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28114854/gastrointestinal-stability-of-dihydromyricetin-myricetin-and-myricitrin-an-in-vitro-investigation
#2
Dong Xiang, Chen-Guang Wang, Wen-Qing Wang, Chun-Yang Shi, Wei Xiong, Meng-Die Wang, Jian-Guo Fang
The gastrointestinal (GI) stability of three flavonoids, dihydromyricetin (DMY), myricetin (MYR), and myricitrin (MYT), was examined in simulated physiological fluids. Several factors that may influence the degradation rate of theses flavonoids were evaluated, including pH and the presence of pepsin and pancreatin enzymes. We found that GI stability followed the order of MYT > DMY > MYR. These flavonoids were stable in simulated gastric fluids and buffer solutions (pH 1.2), but encountered a pseudo-first-order kinetic degradation in simulated intestinal fluids and buffer solutions (pH 6...
January 23, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28092088/erratum-to-dihydromyricetin-improves-hypobaric-hypoxia-induced-memory-impairment-via-modulation-of-sirt3-signaling
#3
Peng Liu, Dan Zou, Ka Chen, Qicheng Zhou, Yanxiang Gao, Yujie Huang, Jundong Zhu, Qianyong Zhang, Mantian Mi
No abstract text is available yet for this article.
January 16, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/27997436/dihydromyricetin-reverses-mrp2-mediated-mdr-and-enhances-anticancer-activity-induced-by-oxaliplatin-in-colorectal-cancer-cells
#4
Ziyuan Wang, Xiaoting Sun, Yuanyuan Feng, Xuan Liu, Lihong Zhou, Hua Sui, Qing Ji, Qiukai E, Jia Chen, Lili Wu, Qi Li
Dihydromyricetin (DMY), extracted from the Chinese herbal medicine Ampelopsis grossedentata, possesses antitumor potential in different types of human cancer cells. Hence, its effects on drug resistance and molecular mechanisms in colorectal cancer (CRC) are still unknown. In our present study, we observed that DMY enhanced the chemosensitivity to oxaliplatin (OXA). DMY increased OXA-induced apoptosis and reduced 5(6)-carboxy-2',7'-dichlorofluorescein accumulation in OXA-resistant CRC HCT116/L-OHP cells. Our mechanistic study suggested that DMY treatment inhibited multidrug resistance protein 2 (MRP2) expression levels and promoter activity, indicating that DMY reduced not only MRP2 transcriptional and translational levels but also its function...
March 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/27984083/dihydromyricetin-delays-the-onset-of-hyperglycemia-and-ameliorates-insulin-resistance-without-excessive-weight-gain-in-zucker-diabetic-fatty-rats
#5
Lei Liu, Jing Wan, Hedong Lang, Mingyu Si, Jundong Zhu, Yong Zhou, Mantian Mi
Many flavonoids are reported to be partial agonists of PPARγ and exert antidiabetic effects with fewer side effects compared with full agonists. Here, we assessed the effects of flavonoid dihydromyricetin (DHM) on glucose homeostasis in male Zucker diabetic fatty rats. Animals were treated with DHM (50-200  mg kg(-1)) or rosiglitazone (4  mg kg(-1)) once a day for 8 weeks. We found that DHM reduced fasting blood glucose and delayed the onset of hyperglycemia by 4 weeks. Furthermore, DHM preserved pancreatic β-cell mass, elevated adiponectin and improved lipid profile more vigorously than rosiglitazone...
October 27, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27951743/determination-of-dihydromyricetin-in-rat-plasma-by-lc-ms-ms-and-its-application-to-a-pharmacokinetic-study
#6
Lu Liu, Xiaolan Yin, Xu Wang, Xiaohua Li
CONTEXT: The pharmacokinetics properties of dihydromyricetin (DHM) are still unknown. OBJECTIVE: This study investigates the pharmacokinetic characteristics of DHM using a sensitive and reliable LC-MS/MS method. MATERIALS AND METHODS: A rapid and sensitive LC-MS/MS method was developed for the determination of DHM in male Sprague-Dawley rat plasma. Twelve rats were equally randomized into two groups, including the intravenous group (2 mg/kg) and the oral group (20 mg/kg)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27820960/isolation-of-a-new-compound-2-butanone-4-glucopyranoside-6-o-gallate-and-other-8-compounds-from-the-anti-inflammatory-leave-extracts-of-memecylon-edule-roxb
#7
Somsak Nualkaew, Suchitra Thongpraditchote, Yuwadee Wongkrajang, Kaoru Umehara, Hiroshi Noguchi
This present study was designed to isolate the compounds of Memecylon edule. The chemical compounds were purified by chromatographic methods and their structures were established on the basis of spectroscopic analyses (UV, MS and NMR). The major isolated compounds were tested for anti-inflammatory activity. The methanolic extracts of M. edule leaves gave a new compound 2-butanone 4-glucopyranoside 6'-O-gallate (1) with eight known compounds, namely, 3,3'-di-O-methylellagic acid 4-O-β-d-glucopyranoside (2), epigallocatechin-3-O-gallate (EGCG) (3), (2R, 3R)-dihydromyricetin-4'-β-d-glucopyranoside (4), myricetin-3-O-α-l-rhamnopyranoside (5), benzyl-(6-O-α-L arabinofuranosyl) O-β-d-glucopyranoside (6), benzyl-(6-O-α-l-rhanmopyranosyl) O-β-d-glucopyranoside (7), 2-phenylethyl-(6-O-β-d-apiofuranosyl)-O-β-d-glucopyranoside (8) and methyl benzoate 2-(6-O-α-l-rhamnosyl)-O-β-d-glucopyranoside (9)...
November 7, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27796348/metabolomics-reveals-the-protective-of-dihydromyricetin-on-glucose-homeostasis-by-enhancing-insulin-sensitivity
#8
Liang Le, Baoping Jiang, Wenting Wan, Wei Zhai, Lijia Xu, Keping Hu, Peigen Xiao
Dihydromyricetin (DMY), an important flavanone found in Ampelopsis grossedentata, possesses antioxidative properties that ameliorate skeletal muscle insulin sensitivity and exert a hepatoprotective effect. However, little is known about the effects of DMY in the context of high-fat diet (HFD)-induced hepatic insulin resistance. Male Sprague-Dawley(SD) rats were fed a HFD(60% fat) supplemented with DMY for 8 weeks. The administration of DMY to the rats with HFD-induced insulin resistance reduces hyperglycemia, plasma levels of insulin, and steatosis in the liver...
October 31, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27793014/dihydromyricetin-protects-against-liver-ischemia-reperfusion-induced-apoptosis-via-activation-of-foxo3a-mediated-autophagy
#9
Yongbiao Chen, Lizhi Lv, Huifeng Pi, Weijia Qin, Jianwei Chen, Dengfang Guo, Jianyu Lin, Xiaobing Chi, Zhelong Jiang, Hejun Yang, Yi Jiang
Liver ischemia and reperfusion (I/R) injury is characterized by defective liver autophagy accompanied by alterations to the endogenous defense system. Dihydromyricetin (DHM) is a natural flavonoid that demonstrates a wide range of physiological functions, and has been implicated as a regulator of autophagy. This study investigates the protective effects of DHM pretreatment on liver injury caused by ischemia/reperfusion (I/R) and elucidates the potential mechanism of DHM-mediated protection. Mice were subjected to 60 minutes of ischemia followed by 5 hours of reperfusion...
22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27788158/genetics-and-biochemistry-of-zero-tannin-lentils
#10
Mahla Mirali, Randy W Purves, Rob Stonehouse, Rui Song, Kirstin Bett, Albert Vandenberg
The zero-tannin trait in lentil is controlled by a single recessive gene (tan) that results in a phenotype characterized by green stems, white flowers, and thin, transparent, or translucent seed coats. Genes that result in zero-tannin characteristics are useful for studies of seed coat pigmentation and biochemical characters because they have altered pigmentation. In this study, one of the major groups of plant pigments, phenolic compounds, was compared among zero-tannin and normal phenotypes and genotypes of lentil...
2016: PloS One
https://www.readbyqxmd.com/read/27784359/-reversal-effect-of-dihydromyricetin-on-drug-resistance-of-k562-a02-cell-line-to-adriamycin
#11
Bi-Rong Li, Le Wang, Wei-Na Han, Lin-Qin Xia, Shu Tang
OBJECTIVE: To investigate the reversal effect of dihydromyricetin(DMY) on drug resistance of K562/A02 cells to adriamycin and explore its possible mechanism. METHODS: K562 and K562/A02 cells were treated with DMY (5, 10, 20, 40, 60, 80 and 100 mg/L) and ADM (100-0.05 mg/L) for 48 h. The viability of K562 cells and K562/A02 cells was tested and the reversal effect of DMY on drug resistance of K562/A02 cells to adriamycin was analyzed by MTT. The relative concentration of ADM in cells was measured by flow cytometry...
October 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/27780933/ampelopsin-attenuates-brain-aging-of-d-gal-induced-rats-through-mir-34a-mediated-sirt1-mtor-signal-pathway
#12
Xianjuan Kou, Xingran Liu, Xianbing Chen, Jie Li, Xiaoqi Yang, Jingjing Fan, Yi Yang, Ning Chen
The underlying molecular mechanisms for aging-related neurodegenerative diseases such as Alzheimer's disease (AD) are not fully understood. Currently, growing evidences have revealed that microRNAs (miRNAs) are involved in aging and aging-related diseases. The up-regulation of miR-34a has been reported to be associated with aging-related diseases, and thus it should be a promising therapeutic target. Ampelopsin, also called dihydromyricetin (DHM), a natural flavonoid from Chinese herb Ampelopsis grossedentata, has been reported to possess multiple pharmacological functions including anti-inflammatory, anti-oxidative and anti-cancer functions...
October 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27738772/the-cardioprotective-effect-of-dihydromyricetin-prevents-ischemia-reperfusion-induced-apoptosis-in-vivo-and-in-vitro-via-the-pi3k-akt-and-hif-1%C3%AE-signaling-pathways
#13
Shasha Liu, Qidi Ai, Kai Feng, Yubing Li, Xiang Liu
Reperfusion therapy is widely used to treat acute myocardial infarction (AMI). However, further injury to the heart induced by rapidly initiating reperfusion is often encountered in clinical practice. A lack of pharmacological strategies in clinics limits the prognosis of patients with myocardial ischemia-reperfusion injury (MIRI). Dihydromyricetin (DMY) is one of the most abundant components in vine tea, commonly known as the tender stems and leaves of Ampelopsis grossedentata. The aim of this study was to evaluate the cardioprotection of DMY against myocardial ischemia-reperfusion (I/R) injury and to further investigate the underlying mechanism...
December 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27719936/a-dual-antibacterial-mechanism-involved-in-membrane-disruption-and-dna-binding-of-2r-3r-dihydromyricetin-from-pine-needles-of-cedrus-deodara-against-staphylococcus-aureus
#14
Yanping Wu, Jinrong Bai, Kai Zhong, Yina Huang, Hong Gao
The antibacterial activity and mechanism of 2R,3R-dihydromyricetin (DMY) against Staphylococcus aureus were investigated. The minimum inhibitory concentration of DMY against S. aureus was 0.125mg/ml, and the growth inhibitory assay also revealed that DMY showed a potent antibacterial activity against S. aureus. Massive nucleotide leakage and flow cytometric analysis demonstrated that DMY disrupted the membrane integrity of S. aureus. Morphological changes and membrane hyperpolarization of S. aureus cells treated with DMY further suggested that DMY destroyed cell membrane...
March 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27686451/dihydromyricetin-suppresses-tnf-%C3%AE-induced-nf-%C3%AE%C2%BAb-activation-and-target-gene-expression
#15
Nina Tang, Juan Ma, Ke Si Wang, Chunliu Mi, Ying Lv, Lian Xun Piao, Guang Hua Xu, Xuezheng Li, Jung Joon Lee, Xuejun Jin
Nuclear factor-kappa B (NF-κB) has been reported to play a pivotal role in many physiological processes including inflammation, apoptosis, and angiogenesis. We discovered a potent natural NF-κB inhibitor, dihydromyricetin, from the traditional herb Ampelopsis grossedentata, which has a long history of use in food and medicine. In this study, we demonstrated the effect of dihydromyricetin on NF-κB activation in TNF-α-induced HeLa cells. Dihydromyricetin was found to markedly inhibit the phosphorylation and degradation of the inhibitor of NF-κB alpha (IκBα), and subsequent nuclear translocation of p65...
November 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27642358/preventive-effect-of-dihydromyricetin-against-cisplatin-induced-nephrotoxicity-in-vitro-and-in-vivo
#16
Fei Wu, Yi Li, Haibo Song, Yuan Zhang, Yuzhu Zhang, Miao Jiang, Fang Wang, Qian Mu, Wen Zhang, Liang Li, Dongqi Tang
Nephrotoxicity is a frequent severe side effect of cisplatin chemotherapy, limiting its clinical use despite being one of the most potent chemotherapy drugs. Dihydromyricetin is a highly abundant compound purified from the leaves of Ampelopsis grossedentata. Previous studies have demonstrated the anti-inflammatory and antioxidative effects of Dihydromyricetin both in vitro and in vivo, but little is known about the effects of Dihydromyricetin on cisplatin-induced nephrotoxicity and its underlying mechanisms...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27586645/dihydromyricetin-from-ampelopsis-grossedentata-inhibits-melanogenesis-through-down-regulation-of-mapk-pka-and-pkc-signaling-pathways
#17
Huey-Chun Huang, Chun-Chieh Liao, Chu-Chun Peng, Jia-Min Lim, Jen-Hung Siao, Chien-Mei Wei, Chien-Chih Chen, Chung-Shing Wu, Tsong-Min Chang
The inhibitory effects of dihydromyricetin purified from Ampelopsis grossedentata on melanogenesis and its antioxidant characteristics were investigated. Assays of tyrosinase activities and melanin content in B16F10 mouse melanoma cells were carried out spectrophotometrically, and the expression of melanogenesis-related proteins was determined by Western blotting. The possible signaling pathways involved in dihydromyricetin-mediated depigmentation were also examined using specific protein kinase regulators...
October 25, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27556431/optimization-of-the-ultrasonic-assisted-extraction-of-bioactive-flavonoids-from-ampelopsis-grossedentata-and-subsequent-separation-and-purification-of-two-flavonoid-aglycones-by-high-speed-counter-current-chromatography
#18
Hongbing Zhang, Guoyong Xie, Mei Tian, Qian Pu, Minjian Qin
The fermented leaf of Ampelopsis grossedentata has been used as a beverage and folk medicine called "vine tea" in the southern region of China. In this paper, the optimum extraction conditions for the maximum recovery amounts of total flavonoids (TF), dihydromyricetin (DMY), myricitrin (MYG) and myricetin (MY) from natural Ampelopsis grossedentata leaves subjected to ultrasonic-assisted extraction (UAE) were determined and optimized by using response surface methodology. The method was employed by the Box-Behnken design (BBD) and Derringer's desirability function using methanol concentration, extraction time, liquid/solid ratio as factors and the contents of TF, DMY, MYG and MY as responses...
August 20, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27539140/suppression-of-reactive-oxygen-species-mediated-erk-and-jnk-activation-sensitizes-dihydromyricetin-induced-mitochondrial-apoptosis-in-human-non-small-cell-lung-cancer
#19
Shang-Jyh Kao, Wei-Jiunn Lee, Jer-Hwa Chang, Jyh-Ming Chow, Chi-Li Chung, Wen-Yueh Hung, Ming-Hsien Chien
Nonsmall cell lung cancer (NSCLC) is the most common type of lung cancer with a high mortality rate and still remains a therapeutic challenge. A strategy for targeting NSCLC is to identify agents that are effective against NSCLC cells while sparing normal cells. Dihydromyricetin (DHM) is the major flavonoid component derived from Ampelopsis grossedentata, which has a long history of use in medicine. Herein, the molecular mechanisms by which DHM exerts its anticancer effects against NSCLC cells were investigated...
August 19, 2016: Environmental Toxicology
https://www.readbyqxmd.com/read/27501707/dihydromyricetin-ameliorates-3np-induced-behavioral-deficits-and-striatal-injury-in-rats
#20
Shuhua Mu, Youlan Li, Bingbing Liu, Weiping Wang, Si Chen, Jiajia Wu, Lisi OuYang, Yaxi Zhu, Keyi Li, Mali Zhan, Zongwei Liu, Yu Jia, Yuxin Ma, Wanlong Lei
Oxidative stress is closely involved in neurodegenerative diseases. The present study aimed to examine the effect of anti-oxidant DHM (dihydromyricetin) on 3NP (3-nitropropionic acid) -induced behavioral deficits of experimental rats and striatal histopathological injury by using behavioral, imaging, biochemistry, histochemistry and molecular biology technologies. The experimental results showed that both motor dysfunctions and learning and memory impairments induced by 3NP were significantly reduced after DHM treatment...
October 2016: Journal of Molecular Neuroscience: MN
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