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Somsak Nualkaew, Suchitra Thongpraditchote, Yuwadee Wongkrajang, Kaoru Umehara, Hiroshi Noguchi
This present study was designed to isolate the compounds of Memecylon edule. The chemical compounds were purified by chromatographic methods and their structures were established on the basis of spectroscopic analyses (UV, MS and NMR). The major isolated compounds were tested for anti-inflammatory activity. The methanolic extracts of M. edule leaves gave a new compound 2-butanone 4-glucopyranoside 6'-O-gallate (1) with eight known compounds, namely, 3,3'-di-O-methylellagic acid 4-O-β-d-glucopyranoside (2), epigallocatechin-3-O-gallate (EGCG) (3), (2R, 3R)-dihydromyricetin-4'-β-d-glucopyranoside (4), myricetin-3-O-α-l-rhamnopyranoside (5), benzyl-(6-O-α-L arabinofuranosyl) O-β-d-glucopyranoside (6), benzyl-(6-O-α-l-rhanmopyranosyl) O-β-d-glucopyranoside (7), 2-phenylethyl-(6-O-β-d-apiofuranosyl)-O-β-d-glucopyranoside (8) and methyl benzoate 2-(6-O-α-l-rhamnosyl)-O-β-d-glucopyranoside (9)...
November 7, 2016: Natural Product Research
Liang Le, Baoping Jiang, Wenting Wan, Wei Zhai, Lijia Xu, Keping Hu, Peigen Xiao
Dihydromyricetin (DMY), an important flavanone found in Ampelopsis grossedentata, possesses antioxidative properties that ameliorate skeletal muscle insulin sensitivity and exert a hepatoprotective effect. However, little is known about the effects of DMY in the context of high-fat diet (HFD)-induced hepatic insulin resistance. Male Sprague-Dawley(SD) rats were fed a HFD(60% fat) supplemented with DMY for 8 weeks. The administration of DMY to the rats with HFD-induced insulin resistance reduces hyperglycemia, plasma levels of insulin, and steatosis in the liver...
October 31, 2016: Scientific Reports
Yongbiao Chen, Lizhi Lv, Huifeng Pi, Weijia Qin, Jianwei Chen, Dengfang Guo, Jianyu Lin, Xiaobing Chi, Zhelong Jiang, Hejun Yang, Yi Jiang
Liver ischemia and reperfusion (I/R) injury is characterized by defective liver autophagy accompanied by alterations to the endogenous defense system. Dihydromyricetin (DHM) is a natural flavonoid that demonstrates a wide range of physiological functions, and has been implicated as a regulator of autophagy. This study investigates the protective effects of DHM pretreatment on liver injury caused by ischemia/reperfusion (I/R) and elucidates the potential mechanism of DHM-mediated protection. Mice were subjected to 60 minutes of ischemia followed by 5 hours of reperfusion...
October 25, 2016: Oncotarget
Mahla Mirali, Randy W Purves, Rob Stonehouse, Rui Song, Kirstin Bett, Albert Vandenberg
The zero-tannin trait in lentil is controlled by a single recessive gene (tan) that results in a phenotype characterized by green stems, white flowers, and thin, transparent, or translucent seed coats. Genes that result in zero-tannin characteristics are useful for studies of seed coat pigmentation and biochemical characters because they have altered pigmentation. In this study, one of the major groups of plant pigments, phenolic compounds, was compared among zero-tannin and normal phenotypes and genotypes of lentil...
2016: PloS One
Bi-Rong Li, Le Wang, Wei-Na Han, Lin-Qin Xia, Shu Tang
OBJECTIVE: To investigate the reversal effect of dihydromyricetin(DMY) on drug resistance of K562/A02 cells to adriamycin and explore its possible mechanism. METHODS: K562 and K562/A02 cells were treated with DMY (5, 10, 20, 40, 60, 80 and 100 mg/L) and ADM (100-0.05 mg/L) for 48 h. The viability of K562 cells and K562/A02 cells was tested and the reversal effect of DMY on drug resistance of K562/A02 cells to adriamycin was analyzed by MTT. The relative concentration of ADM in cells was measured by flow cytometry...
October 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
Xianjuan Kou, Xingran Liu, Xianbing Chen, Jie Li, Xiaoqi Yang, Jingjing Fan, Yi Yang, Ning Chen
The underlying molecular mechanisms for aging-related neurodegenerative diseases such as Alzheimer's disease (AD) are not fully understood. Currently, growing evidences have revealed that microRNAs (miRNAs) are involved in aging and aging-related diseases. The up-regulation of miR-34a has been reported to be associated with aging-related diseases, and thus it should be a promising therapeutic target. Ampelopsin, also called dihydromyricetin (DHM), a natural flavonoid from Chinese herb Ampelopsis grossedentata, has been reported to possess multiple pharmacological functions including anti-inflammatory, anti-oxidative and anti-cancer functions...
October 21, 2016: Oncotarget
Shasha Liu, Qidi Ai, Kai Feng, Yubing Li, Xiang Liu
Reperfusion therapy is widely used to treat acute myocardial infarction (AMI). However, further injury to the heart induced by rapidly initiating reperfusion is often encountered in clinical practice. A lack of pharmacological strategies in clinics limits the prognosis of patients with myocardial ischemia-reperfusion injury (MIRI). Dihydromyricetin (DMY) is one of the most abundant components in vine tea, commonly known as the tender stems and leaves of Ampelopsis grossedentata. The aim of this study was to evaluate the cardioprotection of DMY against myocardial ischemia-reperfusion (I/R) injury and to further investigate the underlying mechanism...
December 2016: Apoptosis: An International Journal on Programmed Cell Death
Yanping Wu, Jinrong Bai, Kai Zhong, Yina Huang, Hong Gao
The antibacterial activity and mechanism of 2R,3R-dihydromyricetin (DMY) against Staphylococcus aureus were investigated. The minimum inhibitory concentration of DMY against S. aureus was 0.125mg/ml, and the growth inhibitory assay also revealed that DMY showed a potent antibacterial activity against S. aureus. Massive nucleotide leakage and flow cytometric analysis demonstrated that DMY disrupted the membrane integrity of S. aureus. Morphological changes and membrane hyperpolarization of S. aureus cells treated with DMY further suggested that DMY destroyed cell membrane...
March 1, 2017: Food Chemistry
Nina Tang, Juan Ma, Ke Si Wang, Chunliu Mi, Ying Lv, Lian Xun Piao, Guang Hua Xu, Xuezheng Li, Jung Joon Lee, Xuejun Jin
Nuclear factor-kappa B (NF-κB) has been reported to play a pivotal role in many physiological processes including inflammation, apoptosis, and angiogenesis. We discovered a potent natural NF-κB inhibitor, dihydromyricetin, from the traditional herb Ampelopsis grossedentata, which has a long history of use in food and medicine. In this study, we demonstrated the effect of dihydromyricetin on NF-κB activation in TNF-α-induced HeLa cells. Dihydromyricetin was found to markedly inhibit the phosphorylation and degradation of the inhibitor of NF-κB alpha (IκBα), and subsequent nuclear translocation of p65...
November 2016: Molecular and Cellular Biochemistry
Fei Wu, Yi Li, Haibo Song, Yuan Zhang, Yuzhu Zhang, Miao Jiang, Fang Wang, Qian Mu, Wen Zhang, Liang Li, Dongqi Tang
Nephrotoxicity is a frequent severe side effect of cisplatin chemotherapy, limiting its clinical use despite being one of the most potent chemotherapy drugs. Dihydromyricetin is a highly abundant compound purified from the leaves of Ampelopsis grossedentata. Previous studies have demonstrated the anti-inflammatory and antioxidative effects of Dihydromyricetin both in vitro and in vivo, but little is known about the effects of Dihydromyricetin on cisplatin-induced nephrotoxicity and its underlying mechanisms...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
Huey-Chun Huang, Chun-Chieh Liao, Chu-Chun Peng, Jia-Min Lim, Jen-Hung Siao, Chien-Mei Wei, Chien-Chih Chen, Chung-Shing Wu, Tsong-Min Chang
The inhibitory effects of dihydromyricetin purified from Ampelopsis grossedentata on melanogenesis and its antioxidant characteristics were investigated. Assays of tyrosinase activities and melanin content in B16F10 mouse melanoma cells were carried out spectrophotometrically, and the expression of melanogenesis-related proteins was determined by Western blotting. The possible signaling pathways involved in dihydromyricetin-mediated depigmentation were also examined using specific protein kinase regulators...
October 25, 2016: Chemico-biological Interactions
Hongbing Zhang, Guoyong Xie, Mei Tian, Qian Pu, Minjian Qin
The fermented leaf of Ampelopsis grossedentata has been used as a beverage and folk medicine called "vine tea" in the southern region of China. In this paper, the optimum extraction conditions for the maximum recovery amounts of total flavonoids (TF), dihydromyricetin (DMY), myricitrin (MYG) and myricetin (MY) from natural Ampelopsis grossedentata leaves subjected to ultrasonic-assisted extraction (UAE) were determined and optimized by using response surface methodology. The method was employed by the Box-Behnken design (BBD) and Derringer's desirability function using methanol concentration, extraction time, liquid/solid ratio as factors and the contents of TF, DMY, MYG and MY as responses...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Shang-Jyh Kao, Wei-Jiunn Lee, Jer-Hwa Chang, Jyh-Ming Chow, Chi-Li Chung, Wen-Yueh Hung, Ming-Hsien Chien
Nonsmall cell lung cancer (NSCLC) is the most common type of lung cancer with a high mortality rate and still remains a therapeutic challenge. A strategy for targeting NSCLC is to identify agents that are effective against NSCLC cells while sparing normal cells. Dihydromyricetin (DHM) is the major flavonoid component derived from Ampelopsis grossedentata, which has a long history of use in medicine. Herein, the molecular mechanisms by which DHM exerts its anticancer effects against NSCLC cells were investigated...
August 19, 2016: Environmental Toxicology
Shuhua Mu, Youlan Li, Bingbing Liu, Weiping Wang, Si Chen, Jiajia Wu, Lisi OuYang, Yaxi Zhu, Keyi Li, Mali Zhan, Zongwei Liu, Yu Jia, Yuxin Ma, Wanlong Lei
Oxidative stress is closely involved in neurodegenerative diseases. The present study aimed to examine the effect of anti-oxidant DHM (dihydromyricetin) on 3NP (3-nitropropionic acid) -induced behavioral deficits of experimental rats and striatal histopathological injury by using behavioral, imaging, biochemistry, histochemistry and molecular biology technologies. The experimental results showed that both motor dysfunctions and learning and memory impairments induced by 3NP were significantly reduced after DHM treatment...
October 2016: Journal of Molecular Neuroscience: MN
Rui Wang, Jiang Pi, Xiaohui Su, Juan Liu, Xing Zeng, Ivan Wong, Lufen Huang, Hua Zhou, Jiye Cai, Ting Li, Liang Liu
Dihydromyricetin (DMY) a flavonoid derived from medicinal plant Ampelopsis grossedentata, possesses anti-oxidative and anti-inflammatory effects in vitro, however, the in vivo anti-inflammatory action of DMY remains unknown. In the current study, carrageenan-induced paw edema in rat, an acute inflammation model, and RAW264.7 macrophages activated by LPS were employed to evaluate the anti-inflammatory potency of DMY in vivo and in vitro. Results showed that DMY significantly attenuated rat paw edema induced by carrageenan...
August 3, 2016: Scanning
Teng-Fei Fan, Tian-Fu Wu, Lin-Lin Bu, Si-Rui Ma, Yi-Cun Li, Liang Mao, Zhi-Jun Sun, Wen-Feng Zhang
Chemotherapy is an effective weapon in the battle against cancer, but numerous cancer patients are either not sensitive to chemotherapy or develop drug resistance to current chemotherapy regimens. Therefore, an effective chemotherapy mechanism that enhances tumor sensitivity to chemotherapeutics is urgently needed. The aim of the present study was to determine the antitumor activity of dihydromyricetin (DHM) on head and neck squamous cell carcinoma (HNSCC) and its underlying mechanisms. We demonstrated that DHM can markedly induce apoptotic cell death and autophagy in HNSCC cells...
July 25, 2016: Oncotarget
Wei Zhang, Shengdong Wang, Houfa Yin, Erman Chen, Deting Xue, Qiang Zheng, Xiang Gao, Zhijun Pan
Substantial evidence has demonstrated that the decreased osteogenic differentiation of bone mesenchymal stem cells (BMSCs) is closely related to bone metabolic diseases. Thus, it is very important to develop several potentially useful therapeutic agents to enhance BMSC osteogenesis. Flavonoids show promise in enhancing bone mass. Dihydromyricetin (DMY), a type of flavonoid, has not yet been investigated regarding its effects on BMSC osteogenesis. To investigate the effects of DMY on osteogenesis, human BMSCs were induced with or without DMY...
December 2016: Fundamental & Clinical Pharmacology
Zhao-Xiang Ren, Ya-Fei Zhao, Ting Cao, Xue-Chu Zhen
AIM: It is general believed that mitochondrial dysfunction and oxidative stress play critical roles in the pathology of Parkinson's disease (PD). Dihydromyricetin (DHM), a natural flavonoid extracted from Ampelopsis grossedentata, has recently been found to elicit potent anti-oxidative effects. In the present study, we explored the role of DHM in protecting dopaminergic neurons. METHODS: Male C57BL/6 mice were intraperitoneally injected with 1-methyl4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) for 7 d to induce PD...
July 4, 2016: Acta Pharmacologica Sinica
Caifeng Xie, Zhen Chen, Chengfu Zhang, Xin Xu, Jiangbo Jin, Weihua Zhan, Tianyu Han, Jianbin Wang
AIMS: Dihydromyricetin (DMY), a flavonoid component isolated from Ampelopsis grossedentata, was recently reported to ameliorate nonalcoholic fatty liver disease (NAFLD) in patients. However, the underlying mechanisms of this action remain unknown. Here, we evaluate the effect of DMY on an in vitro model of NAFLD and investigate the signal transduction pathways underlying DMY treatment. MAIN METHODS: Oleic acid (OA) induced hepatic steatosis was established in L02 and HepG2 cells as in vitro model of NAFLD...
July 15, 2016: Life Sciences
Zhe He, Li Zhang, Cuiqin Zhuo, Fujun Jin, Yifei Wang
UVA irradiation stimulates the production of reactive oxygen species (ROS), which results in oxidative stress, cellular damage, and ultimately, cell death by interacting with other intracellular molecules. In the present study, we explored the protective role of Dihydromyricetin (DHM,1.25-10μM) against UVA-induced inflammation response and apoptosis in the human keratinocyte cell line (HaCaT cells) and the underlying mechanisms. DHM pre-treatment significantly increased HaCaT cell viability and suppressed UVA-induced production of inflammatory cytokines, as well as apoptosis of HaCaT cells...
August 2016: Journal of Photochemistry and Photobiology. B, Biology
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