keyword
MENU ▼
Read by QxMD icon Read
search

Dihydromyricetin

keyword
https://www.readbyqxmd.com/read/29660761/interactions-of-dihydromyricetin-a-flavonoid-from-vine-tea-ampelopsis-grossedentata-with-gut-microbiota
#1
Li Fan, Xinyuan Zhao, Qing Tong, Xiya Zhou, Jing Chen, Wei Xiong, Jianguo Fang, Wenqing Wang, Chunyang Shi
Dihydromyricetin (DMY) is the main bioactive constituent in vine tea (Ampelopsis grossedentata), which was predominantly distributed in the gastrointestinal tract and showed poor oral bioavailability. Our aim was to systematically investigate the interactions of DMY with gut microbiota. Through the metabolism study of DMY by fecal microflora in vitro, it was found that DMY could be metabolized into three metabolites by fecal microflora via reduction and dehydroxylation pathways, and the dehydroxylation metabolite was the dominant one...
April 16, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29656207/dihydromyricetin-relieves-rheumatoid-arthritis-symptoms-and-suppresses-expression-of-pro-inflammatory-cytokines-via-the-activation-of-nrf2-pathway-in-rheumatoid-arthritis-model
#2
Jianguo Chu, Xiujun Wang, Huanjie Bi, Lifeng Li, Mingguang Ren, Jingwei Wang
Rheumatoid arthritis (RA) is a systemic inflammatory and autoimmune disease. In this research, we estimated the protective effects of Dihydromyricetin (DMY) on RA induced by Complete Freund's Adjuvant (CFA). We found that DMY effectively relieved rheumatoid arthritis symptoms, such as body weight change, paw swelling and rheumatoid arthritis scores. In addition, we also observed that DMY significantly lowered the immune organ indexes (including thymus and spleen) and exhibited the anti-inflammatory effect in CFA-induced rheumatoid arthritis...
April 12, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29554804/reduction-of-dihydrokaempferol-by-vitis-vinfera-dihydroflavonol-4-reductase-to-produce-orange-pelargonidin-type-anthocyanins
#3
Sha Xie, Ting Zhao, Zhen-Wen Zhang, Jiangfei Meng
Vitis vinifera has been thought to be unable to produce pelargonidin-type anthocyanins because its dihydroflavonol 4-reductase (DFR) does not efficiently reduce dihydrokaempferol. However, in this study, pelargonidin 3-O-glucoside was detected in the skin of V. vinifera 'Pinot Noir', 'Cabernet Sauvignon' and 'Yan73', as well as in the flesh of 'Yan73' using HPLC-ESI-MS/MS. Additionally, pelargonidin 3-O-(6-acetyl)-glucoside was detected in 'Yan73' skin and flesh for the first time. To further confirm the presence of pelargonidin-type anthocyanins in these grape cultivars, their DFRs were cloned, expressed in Escherichia coli and purified...
March 20, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29522258/protective-effect-of-dihydromyricetin-on-lps-induced-acute-lung-injury
#4
Bo Wang, Yunfang Xiao, Xiaofeng Yang, Yanhao He, Ting Jing, Weirong Wang, Jiye Zhang, Rong Lin
Dihydromyricetin (DHM), a bioactive flavonoid component isolated from Ampelopsis grossedentata, is known to have anti-inflammatory effect, but the effect of DHM on acute lung injury (ALI) is largely unknown. Here, we investigated the effect of DHM on ALI and the underlying mechanism by bioinformatic analyses and animal experiments. We found that pretreatment with DHM ameliorated lung pathological changes and suppressed the inflammation response in lung tissues after LPS challenge. The potential targets of DHM were predicted by DDI-CPI and DRAR-CPI tools and analyzed using the STRING server to predict the functionally related signaling pathways, such as MAPK signaling...
March 9, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29505925/dihydromyricetin-ameliorates-foam-cell-formation-via-lxr%C3%AE-abca1-abcg1-dependent-cholesterol-efflux-in-macrophages
#5
Yi Zeng, Yi Peng, Kun Tang, Yu Qin Wang, Zhe Yu Zhao, Xin Yu Wei, Xiao Le Xu
As the most abundant flavonoid in Ampelopsis grossedentata, the protective effects of dihydromyricetin on atherosclerosis have been well established, yet the detailed mechanisms are not fully understood. The aim of the present study was to examine the effect of dihydromyricetin on lipid accumulation and the underlying molecular mechanisms in macrophages and ApoE-/- mice. Incubation with dihydromyricetin significantly attenuated oxidized low-density lipoprotein (ox-LDL)-mediated cholesterol and lipid accumulation in THP-1-derived macrophages, which was due to increased cholesterol efflux...
March 2, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29493145/-correlation-analysis-between-quality-and-habitat-phenotype-of-hovenia-acerba
#6
Cong Liu, Jia-Liang Wu, Na Zhao, Jian Sun, Xiao-Xia Shen, Zhi-An Wang
The contents of dihydromyricetin and total flavonoids of Hovenia acerba seeds were detected by HPLC-DAD and UV spectrophotometer. And then the correlation between the habitat, phenotype and quality of H. acerba seeds were deeply studied. There were big differences in both appearance and quality among the H. acerba seeds from different places. It showed that the content of dihydromyricetin in H. acerba seeds was 0.41-9.81 mg•g⁻¹, and the content of total flavonoids was 5.52-21.98 mg•g⁻¹. The cluster analysis showed that the quality of H...
December 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29468960/the-discovery-of-antibacterial-natural-compound-based-on-peptide-deformylase
#7
Li Liang, Qianqian Zhou, Zhixiang Hao, Fanfan Wang, Yasheng Zhu, Qisi Lin, Jian Gao
BACKGROUND: In recent years, Staphylococcus aureus have developed resistance to medicines used for the treatment of human infections. Therefore, the search for antibacterial agents of high potency against Staphylococcus aureus is of great concern. Peptide deformylase (PDF), a metalloprotease catalyzing the removal of a formyl group from newly synthesized proteins, has been considered to be an important antibacterial drug target. OBJECTIVE: To discover novel antibacterial drugs based on Staphylococcus aureus peptide deformylase...
February 20, 2018: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/29425256/dihydromyricetin-improves-type-2-diabetes-induced-cognitive-impairment-via-suppressing-oxidative-stress-and-enhancing-brain-derived-neurotrophic-factor-mediated-neuroprotection-in-mice
#8
Hongyan Ling, Zemei Zhu, Jihua Yang, Jianqin He, Sisi Yang, Di Wu, Shuidong Feng, Duanfang Liao
Type 2 diabetes mellitus (T2DM) leads to cognitive impairment (CI), but there have been no effective pharmacotherapies or drugs for cognitive dysfunction in T2DM. Dihydromyricetin (DHM) is a natural flavonoid compound extracted from the leaves of Ampelopsis grossedentata and has various pharmacological effects including anti-oxidant and anti-diabetes. Thus, we investigated the effects of DHM on CI in T2DM mouse model and its possible mechanism. To induce T2DM, mice were fed with high-sugar and high-fat diet for 8 weeks, followed by a low dose streptozotocin (STZ) administration...
February 7, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29331105/dietary-factors-modulate-colonic-tumorigenesis-through-the-interaction-of-gut-microbiota-and-host-chloride-channels
#9
Yong Zhang, Chao Kang, Xiao-Lan Wang, Min Zhou, Meng-Ting Chen, Xiao-Hui Zhu, Kai Liu, Bin Wang, Qian-Yong Zhang, Jun-Dong Zhu, Man-Tian Mi
SCOPE: In recent decades, the association among diet, gut microbiota, and the risk of colorectal cancer (CRC) has been established. Gut microbiota and associated metabolites, such as bile acids and butyrate, are now known to play a key role in CRC development. The aim of this study is to identify that the progression to CRC is influenced by cholic acid, sodium butyrate, a high-fat diet, or different dose of dihydromyricetin (DMY) interacted with gut microbiota. METHODS AND RESULTS: An AOM/DSS (azoxymethan/dextran sodium sulfate) model is established to study the gut microbiota compsition before and after tumor formation during colitis-induced tumorigenesis...
March 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29310441/dihydromyricetin-ameliorates-nonalcoholic-fatty-liver-disease-by-improving-mitochondrial-respiratory-capacity-and-redox-homeostasis-through-modulation-of-sirt3-signaling
#10
Xianglong Zeng, Jining Yang, Ou Hu, Juan Huang, Li Ran, Mengting Chen, Yu Zhang, Xi Zhou, Jundong Zhu, Qianyong Zhang, Long Yi, Mantian Mi
AIMS: Our previous clinical trial indicated that the flavonoid dihydromyricetin (DHM) could improve hepatic steatosis in patients with nonalcoholic fatty liver disease (NAFLD), altough the potential mechanisms of these effects remained elusive. Here, we investigated the hepatoprotective role of DHM on high-fat diet (HFD)-induced NAFLD. RESULTS: DHM supplementation could effectively ameliorate the development of NAFLD by inhibiting hepatic lipid accumulation both in HFD-fed wild-type mice and in palmitic acid-induced hepatocytes...
February 21, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29258286/optimizing-the-maximum-recovery-of-dihydromyricetin-from-chinese-vine-tea-ampelopsis-grossedentata-using-response-surface-methodology
#11
Umair Muhammad, Hedong Lu, Juan Wang, Jinzhi Han, Xiaoyu Zhu, Zhaoxin Lu, Sultana Tayyaba, Yousef I Hassan
This work provides an optimized extraction approach intended to maximize the recovery of dihydromyricetin (DHM) from Chinese vine tea ( Ampelopsis grossedentata ) leaves. The presented work adopts a Box-Behnken design as a response surface methodology to understand the role and influence of specific extraction parameters including: time, temperature, and solvent composition/ethanol (%) on DHM final yields. Initially, single factor experiments were used to delineate the role of above factors (temperature, time, and solvent composition) before proceeding with three factors-three levels Box-Behnken design with 17 separate runs to assess the effect of multifactorial treatments on DHM recovery rates...
December 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29235425/antibacterial-effect-of-2r-3r-dihydromyricetin-on-the-cellular-functions-of-staphylococcus-aureus
#12
Yan-Ping Wu, Jin-Rong Bai, Kai Zhong, Ding-Ding Bai, Yi-Na Huang, Kai Xiao, Yun Ran, Hong Gao
The C-3-OH, C-4 carbonyl oxygen and hydrogenation of C2=C3 bond on the C-ring of 2R,3R-dihydromyricetin (DMY) proved to be not necessary for the antibacterial activity against Staphylococcus aureus. DMY significantly decreased the intracellular ATP of S. aureus cells but had few effects on pHin , proline oxidation, succinate dehydrogenase activity or malate dehydrogenase activity.
January 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29228897/a-new-buckwheat-dihydroflavonol-4-reductase-dfr-with-a-unique-substrate-binding-structure-has-altered-substrate-specificity
#13
Kenjiro Katsu, Rintaro Suzuki, Wataru Tsuchiya, Noritoshi Inagaki, Toshimasa Yamazaki, Tomomi Hisano, Yasuo Yasui, Toshiyuki Komori, Motoyuki Koshio, Seiji Kubota, Amanda R Walker, Kiyoshi Furukawa, Katsuhiro Matsui
BACKGROUND: Dihydroflavonol 4-reductase (DFR) is the key enzyme committed to anthocyanin and proanthocyanidin biosynthesis in the flavonoid biosynthetic pathway. DFR proteins can catalyse mainly the three substrates (dihydrokaempferol, dihydroquercetin, and dihydromyricetin), and show different substrate preferences. Although relationships between the substrate preference and amino acids in the region responsible for substrate specificity have been investigated in several plant species, the molecular basis of the substrate preference of DFR is not yet fully understood...
December 11, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29225170/dihydromyricetin-sensitizes-human-acute-myeloid-leukemia-cells-to-retinoic-acid-induced-myeloid-differentiation-by-activating-stat1
#14
Ming-Hui He, Qiang Zhang, Gang Shu, Ju-Chun Lin, Ling Zhao, Xiao-Xia Liang, Lizi Yin, Fei Shi, Hua-Lin Fu, Zhi-Xiang Yuan
The success of all-trans retinoic acid (ATRA) in differentiation therapy for patients with acute promyelocytic leukemia (APL) highly encourages researches to apply a new combination therapy based on ATRA. Therefore, research strategies to further sensitize cells to retinoids are urgently needed. In this study, we showed that Dihydromyricetin (DMY), a 2,3-dihydroflavonol compound, exhibited a strong synergy with ATRA to promote APL NB4 cell differentiation. We observed that DMY sensitized the NB4 cells to ATRA-induced cell growth inhibition, CD11b expression, NBT reduction and myeloid regulator expression...
January 8, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29193391/dihydromyricetin-inhibits-nlrp3-inflammasome-dependent-pyroptosis-by-activating-the-nrf2-signaling-pathway-in-vascular-endothelial-cells
#15
Qin Hu, Ting Zhang, Long Yi, Xi Zhou, Mantian Mi
Increasing evidence demonstrates that pyroptosis, pro-inflammatory programmed cell death, is linked to atherosclerosis; however, the underlying mechanisms remain to be elucidated. Dihydromyricetin (DHM), a natural flavonoid, was reported to exert anti-oxidative and anti-inflammatory bioactivities. However, the effect of DHM on atherosclerosis-related pyroptosis has not been studied. In the present study, palmitic acid (PA) treatment led to pyroptosis in human umbilical vein endothelial cells (HUVECs), as evidenced by caspase-1 activation, LDH release, and propidium iodide-positive staining; enhanced the maturation and release of proinflammatory cytokine IL-1β and activation of the NLRP3 inflammasome; and markedly increased intracellular reactive oxygen species (ROS) and mitochondrial ROS (mtROS) levels...
November 29, 2017: BioFactors
https://www.readbyqxmd.com/read/29160030/dihydromyricetin-enhances-glucose-uptake-by-inhibition-of-mek-erk-pathway-and-consequent-down-regulation-of-phosphorylation-of-ppar%C3%AE-in-3t3-l1-cells
#16
Lei Liu, Min Zhou, Hedong Lang, Yong Zhou, Mantian Mi
Accumulating evidence suggests that inhibition of mitogen-activated protein kinase signalling can reduce phosphorylation of peroxisome proliferator-activated receptor γ (PPARγ) at serine 273, which mitigates obesity-associated insulin resistance and might be a promising treatment for type 2 diabetes. Dihydromyricetin (DHM) is a flavonoid that has many beneficial pharmacological properties. In this study, mouse fibroblast 3T3-L1 cells were used to investigate whether DHM alleviates insulin resistance by inhibiting PPARγ phosphorylation at serine 273 via the MEK/ERK pathway...
November 21, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29128706/consumption-of-ellagic-acid-and-dihydromyricetin-synergistically-protects-against-uv-b-induced-photoaging-possibly-by-activating-both-tgf-%C3%AE-1-and-wnt-signaling-pathways
#17
Na Rang Moon, Suna Kang, Sunmin Park
Ellagic acid (EGA) and dihydromyricetin (DHM) are both found in fruits and vegetables are used for anti-aging treatment for the skin. The anti-photoaging efficacy of EGA and DHM was investigated in UV-B irradiated skin in vivo and the involvement of transforming growth factor (TGF)-β1 and wnt signaling pathways were examined in vitro. HaCaT cells were treated with either 50μM EGA, 50μM DHM or 25μM EGA+25μM DHM before 100mJ/cm2 UV-B exposure, and then oxidative stress and inflammation was measured. The involvement of TGF-β1 and wnt signaling was measured using their inhibitors, respectively, in HaCaT cells...
January 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29078260/dihydromyricetin-prevents-monocrotaline-induced-pulmonary-arterial-hypertension-in-rats
#18
Qinghai Li, Jun Wang, Xianying Zhu, Zhilin Zeng, Xiaomei Wu, Yongjian Xu, Jungang Xie, Jun Yu
Pulmonary artery hypertension (PAH) is a chronic and deadly disease, for which effective medical treatments are lacking. Here, we investigated whether 2R,3R-dihydromyricetin (DHM) could prevent monocrotaline (MCT)-induced PAH in rats. The MCT-injected rats were treated with normal saline or DHM (100mg/kg body weight/d) for 4 weeks, followed by measurements of right ventricular systolic pressure (RVSP), right ventricular hypertrophy index (RVHI), pulmonary arterial remodeling (PAR), and expression levels of IL-6, TNF-α, and IL-10...
December 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29067862/molecular-inhibitory-mechanism-of-dihydromyricetin-on-mushroom-tyrosinase
#19
Jianmin Chen, Shiqi Liu, Ziyao Huang, Weiyue Huang, Qinglian Li, Yaling Ye
Tyrosinase is the rate-limiting enzyme for controlling the production of melanin in the human body, and overproduction of melanin can lead to a variety of skin disorders. In this paper, the inhibitory kinetics of Dihydromyricetin (DHM) on tyrosinase and their binding mechanism were determined using spectroscopy, molecular docking, antioxidant assays and chromatography. The spectroscopic results indicate that DHM reversibly inhibits tyrosinase in a mix-type manner through a multiphase kinetic process with the IC50 of 849...
October 25, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29058041/dihydromyricetin-exerts-a-rapid-antidepressant-like-effect-in-association-with-enhancement-of-bdnf-expression-and-inhibition-of-neuroinflammation
#20
Zhaoxiang Ren, Pengju Yan, Liushuai Zhu, Huicui Yang, Yafei Zhao, Brian P Kirby, John L Waddington, Xuechu Zhen
RATIONALE: Major depressive disorder (MDD) is a highly prevalent illness that affects large populations across the world, and increasing evidence suggests that neuroinflammation and levels of brain-derived neurotrophic factor (BDNF) are closely related to depression. Dihydromyricetin (DHM) is a kind of flavonoid natural product that has been reported to display multiple pharmacological effects, including anti-inflammatory and anti-oxidative properties, and these may contribute to ameliorate MDD...
January 2018: Psychopharmacology
keyword
keyword
1566
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"