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https://www.readbyqxmd.com/read/29355086/a-trauma-informed-analysis-of-the-violence-against-women-act-s-provisions-for-undocumented-immigrant-women
#1
Nadine Shaanta Murshid, Elizabeth A Bowen
Immigrant women in the United States are among the groups disproportionately affected by intimate partner violence (IPV). Undocumented immigrants generally have fewer resources for coping with violence and may experience a range of personal, cultural, and immigration status-related barriers to reporting violence and accessing help. Thus, undocumented immigrant victims of IPV could benefit significantly from policies that promote access to trauma-informed services and legal options. This article applies a trauma-informed policy analysis framework to the Violence Against Women Act's immigration protections to demonstrate how the Act's U-Visa provisions and implementation practices could be improved by incorporating trauma-informed principles of trustworthiness and transparency, empowerment, choice, safety, collaboration, and intersectionality...
January 1, 2018: Violence Against Women
https://www.readbyqxmd.com/read/29343521/t-type-ca2-channels-t-for-targetable
#2
REVIEW
Marta C Sallán, Anna Visa, Soni Shaikh, Mireia Nàger, Judit Herreros, Carles Cantí
In the past decade, T-type Ca2+ channels (TTCC) have been unveiled as key regulators of cancer cell biology and thus have been proposed as chemotherapeutic targets. Indeed, in vitro and in vivo studies indicate that TTCC pharmacologic blockers have a negative impact on the viability of cancer cells and reduce tumor size, respectively. Consequently mibefradil, a TTCC blocker approved in 1997 as an antihypertensive agent but withdrawn in 1998 because of drug-drug interactions, was granted 10 years later the orphan drug status by the FDA to investigate its efficacy against brain, ovary, and pancreatic cancer...
January 17, 2018: Cancer Research
https://www.readbyqxmd.com/read/29327240/geriatric-oncology-in-spain-survey-results-and-analysis-of-the-current-situation
#3
R Gironés, I Morilla, C Guillen-Ponce, M D Torregrosa, I Paredero, E Bustamante, S Del Barco, G Soler, B Losada, L Visa, E Llabrés, B Fox, J L Firvida, R Blanco, M Antonio, F Aparisi, M Pi-Figueras, E Gonzalez-Flores, M J Molina-Garrido, J Saldaña
INTRODUCTION: Geriatric oncology (GO) is a discipline that focuses on the management of elderly patients with cancer. The Spanish Society of Medical Oncology (SEOM) created a Working group dedicated to geriatric oncology in February 2016. OBJECTIVES: The main goal of this study was to describe the current situation in Spain regarding the management of elderly cancer patients through an online survey of medical oncologists. METHODS: A descriptive survey was sent to several hospitals by means of the SEOM website...
December 11, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29313411/inhibition-of-wnt-ctnnb1-signaling-upregulates-sqstm1-and-sensitizes-glioblastoma-cells-to-autophagy-blockers
#4
Mireia Nager, Marta Crespí Sallán, Anna Visa, Charumathi Pushparaj, Maria Santacana, Anna Macià, Andrée Yeramian, Carles Cantí, Judit Herreros
WNT-CTNN1B signaling promotes cancer cell proliferation and stemness. Furthermore, recent evidence indicates that macroautophagy/autophagy regulates WNT signaling. Here we investigated the impact of inhibiting WNT signaling on autophagy in glioblastoma (GBM), a devastating brain tumor. Inhibiting TCF, or silencing TCF4 or CTNNB1/β-catenin upregulated SQSTM1/p62 in GBM at transcriptional and protein levels and, in turn, autophagy. DKK1/Dickkopf1, a canonical WNT receptor antagonist, also induced autophagic flux...
January 9, 2018: Autophagy
https://www.readbyqxmd.com/read/29302170/at-the-nexus-how-hiv-related-immigration-policies-affect-foreign-nationals-and-citizens-in-south-korea
#5
Jessica M Keralis
Effective HIV prevention requires the protection and empowerment of marginalized groups at high risk of infection. However, many policies persist that stigmatize these groups and hinder HIV prevention efforts, including HIV-related travel restrictions. In the Republic of Korea, which requires HIV tests for certain visa categories, these restrictions negatively affect the national HIV response and access to accurate information on effective HIV prevention. In addition, they violate migrants' human rights to confidentiality and informed consent to testing and the rights of persons living with HIV (PLHIV) to privacy, work, medical care, bodily integrity, and freedom from discrimination...
December 2017: Health and Human Rights
https://www.readbyqxmd.com/read/29260258/reproducibility-of-shear-wave-elastography-measuresof-the-achilles-tendon
#6
Catherine Payne, Peter Watt, Mara Cercignani, Nick Webborn
OBJECTIVE: To assess the reproducibility of shear wave elastography (SWE) measures in the Achilles tendon (AT) in vivo. MATERIALS AND METHODS: Shear wave velocity (SWV) of 14 healthy volunteers [7 males, 7 females; mean age 26.5 ± 3.8 years, mean height 171.6 ± 10.9 cm, mean Victorian Institute of Sports Assessment Achilles questionnaire (VISA-A) score 99.4 ± 1.2] was measured with the foot relaxed and fixed at 90°. Data were collected over five consecutive measures and 5 consecutive days...
December 19, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29243921/extra-sugar-on-vancomycin-new-analogues-for-combating-multidrug-resistant-staphylococcus-aureus-and-vancomycin-resistant-enterococci
#7
Dongliang Guan, Feifei Chen, Lun Xiong, Feng Tang, Faridoon Faridoon, Yunguang Qiu, Naixia Zhang, Likun Gong, Jian Li, Lefu Lan, Wei Huang
Lipophilic substitution on vancomycin is an effective strategy for development of novel vancomycin analogues against drug-resistant bacteria by enhancing bacterial cell wall interaction. However, hydrophobic structures usually led to long elimination half-life and accumulative toxicity, therefore hydrophilic fragments were also introduced to the lipo-vancomycin to regulate their PK/PD properties. Here, we synthesized a series of new vancomycin analogues carrying various sugar moieties on the 7th-amino acid phenyl ring and lipophilic substitutions on vancosamine with extensive SAR analysis...
December 15, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29243920/novel-terminal-bipheny-based-diapophytoene-desaturases-crtn-inhibitors-as-anti-mrsa-visr-lrsa-agents-with-reduced-herg-activity
#8
Baoli Li, Shuaishuai Ni, Fei Mao, Feifei Chen, Yifu Liu, Hanwen Wei, Wenhua Chen, Jin Zhu, Lefu Lan, Jian Li
CrtN has been identified as an attractive and druggable target for treating pigmented S. aureus infections. More than 100 new compounds were synthesized that target the overwhelming the defects of the CrtN inhibitor 1. Analogs 23a-b demonstrated significant activity against pigmented S. aureus Newman and thirteen MRSA strains (IC50 = 0.02~10.5 nM), along with lower hERG inhibition (IC50 > 30 μM, ~10-fold decrease in comparison with 1). Furthermore, 23a-b were confirmed to reduce the staphylococcal load in the kidney and heart in a mice model with normal treatment deeper than pretreatment ones, comparable even with vancomycin and linezolid...
December 15, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29242093/efficacy-and-safety-of-chemotherapy-in-older-versus-non-older-patients-with-advanced-gastric-cancer-a-real-world-data-non-inferiority-analysis
#9
Laura Visa, Paula Jiménez-Fonseca, Elena Asensio Martínez, Raquel Hernández, Ana Custodio, Marcelo Garrido, Antonio Viudez, Elvira Buxo, Isabel Echavarria, Juana María Cano, Ismael Macias, Montserrat Mangas, Eva Martínez de Castro, Teresa García, Felipe Álvarez Manceñido, Ana Fernández Montes, Aitor Azkarate, Federico Longo, Asunción Díaz Serrano, Carlos López, Alicia Hurtado, Paula Cerdá, Raquel Serrano, Aitziber Gil-Negrete, Alfonso Martín Carnicero, Paola Pimentel, Avinash Ramchandani, Alberto Carmona-Bayonas
OBJECTIVE: Advanced gastric cancer (AGC) is a common neoplasm in older adults. Nevertheless, there are few specific management data in the literature. The aim of this study was to assess non-inferiority of survival and efficacy-related outcomes of chemotherapy used in older vs non-older patients with AGC. MATERIALS AND METHODS: We recruited 1485 patients from the AGAMENON registry of AGC treated with polychemotherapy between 2008-2017. A statistical analysis was conducted to prove non-inferiority for overall survival (OS) associated with the use of chemotherapy schedules in individuals ≥70 vs...
December 11, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29237355/cross-cultural-adaptation-of-the-victorian-institute-of-sports-assessment-achilles-visa-a-questionnaire-for-spanish-athletes
#10
Sergio Hernández-Sánchez, Emilio José Poveda-Pagán, Yasser Alakhdar, Maria Dolores Hidalgo-Montesinos, César Fernández-de-Las-Peñas, José L Arias-Buría
Study Design Clinical measurement study. Background Achilles tendinopathy is a prevalent sport-related injury. The Victorian Institute of Sports Assessment-Achilles (VISA-A) questionnaire is a widely-used patient-reported outcome to assess the severity of symptoms for this injury. Objective To adapt the VISA-A questionnaire into Spanish and to assess its psychometric properties. Methods Cross-cultural adaptation was conducted according to recommended guidelines. The Spanish VISA-A (VISA-A-Sp) questionnaire was administered to 210 subjects: 70 healthy students, 70 active at risk subjects (participating in running and jumping) and 70 patients with Achilles tendinopathy diagnosis...
December 13, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29236188/contributors-to-nonsuicidal-self-injury-in-incarcerated-youth
#11
Larkin Street McReynolds, Gail Wasserman, Elise Ozbardakci
BACKGROUND: Despite elevations in risks associated with self-injurious behavior among community adolescents, the degree to which these features are associated with self-injury among incarcerated youth has rarely been examined. Although the DSM-5 recently proposed a distinct category of nonsuicidal self-injury (NSSI), most studies of youths in forensic settings have not distinguished between subtypes of self-harming individuals. METHODS: Demographic, offense, and disorder contributors to NSSI in incarcerated youths of both genders (N = 358) were examined via a computerized self-report instrument (VISA), largely consistent with DSM-5...
December 13, 2017: Health & Justice
https://www.readbyqxmd.com/read/29231998/phosphorylated-tyr142-%C3%AE-catenin-localizes-to-centrosomes-and-is-regulated-by-syk
#12
D Bhardwaj, M Náger, A Visa, M C Sallán, P J Coopman, C Cantí, J Herreros
β-catenin is a central component of adherent junctions and a key effector of canonical Wnt signalling, in which dephosphorylated Ser/Thr β-catenin regulates gene transcription. β-catenin phosphorylation at Tyr142 (PTyr142 β-catenin), which is induced by receptor and Src family Tyr kinases, represents a previously described β-catenin switch from adhesive to migratory roles. In addition to classical β-catenin roles, phosphorylated Ser/Thr β-catenin and total β-catenin were involved in centrosomal functions, including mitotic spindle formation and centrosome separation...
December 12, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29221624/international-medical-graduates-in-nephrology-roles-rules-and-future-risks
#13
Jeffrey S Berns, Muriel Ghosn, Rodolfo R Altamirano
International medical graduates (IMGs) have become an increasingly essential part of many residency and fellowship programs in the United States. IMGs, who may be of either US or non-US citizenship, contribute significantly to the physician workforce across this country, particularly in underserved areas, as well as in their home countries on their return after training. Approximately 65% of nephrology fellows are IMGs, with most of these being non-US citizens. Non-US IMG applications for nephrology fellowship have been declining, exacerbating an ongoing shortage of nephrology trainees...
December 5, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29210775/isometric-exercise-to-reduce-pain-in-patellar-tendinopathy-in-season-is-it-effective-on-the-road
#14
Ebonie Rio, Craig Purdam, Michael Girdwood, Jill Cook
OBJECTIVE: To investigate the effectiveness of an isometric squat exercise using a portable belt, on patellar tendon pain and function, in athletes during their competitive season. DESIGN: Case series with no requirements to change any aspect of games or training. The object of this pragmatic study was to investigate this intervention in addition to "usual management." A control or sham intervention was considered unacceptable to teams. SETTING: In-season...
November 27, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29203466/visa-problems-mean-nhs-is-losing-uk-trained-gps-doctors-warn
#15
Abi Rimmer
No abstract text is available yet for this article.
December 4, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29200950/isolation-and-determination-of-four-potential-antimicrobial-components-from-pseudomonas-aeruginosa-extracts
#16
Ling-Qing Xu, Jian-Wen Zeng, Chong-He Jiang, Huan Wang, Yu-Zhen Li, Wei-Hong Wen, Jie-Hua Li, Feng Wang, Wei-Jen Ting, Zi-Yong Sun, Chih-Yang Huang
Background:Pseudomonas aeruginosa can cause disease and also can be isolated from the skin of healthy people. Additionally, it exhibits certain antimicrobial effects against other microorganisms.Methods: We collected 60 strains of P. aeruginosa and screened their antimicrobial effects against Staphylococcus aureus (ATCC 25923) using the filter paper-disk method, the cross-streaking method and the co-culture method and then evaluated the antimicrobial activity of the chloroform-isolated S. aureus extracts against methicillin-resistant S...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29187905/nanoparticle-delivery-of-mir-34a-eradicates-long-term-cultured-breast-cancer-stem-cells-via-targeting-c22orf28-directly
#17
Xiaoti Lin, Weiyu Chen, Fengqin Wei, Binhua P Zhou, Mien-Chie Hung, Xiaoming Xie
Rationale: Cancer stem cells (CSCs) have been implicated as the seeds of therapeutic resistance and metastasis, due to their unique abilities of self-renew, wide differentiation potentials and resistance to most conventional therapies. It is a proactive strategy for cancer therapy to eradicate CSCs. Methods: Tumor tissue-derived breast CSCs (BCSC), including XM322 and XM607, were isolated by fluorescence-activated cell sorting (FACS); while cell line-derived BCSC, including MDA-MB-231.SC and MCF-7.SC, were purified by magnetic-activated cell sorting (MACS)...
2017: Theranostics
https://www.readbyqxmd.com/read/29166934/arthroscopic-patellar-release-for-treatment-of-chronic-symptomatic-patellar-tendinopathy-long-term-outcome-and-influential-factors-in-an-athletic-population
#18
Gernot Lang, Jan M Pestka, Dirk Maier, Kaywan Izadpanah, Norbert Südkamp, Peter Ogon
BACKGROUND: Arthroscopic patellar release (APR) is utilized for minimally invasive surgical treatment of patellar tendinopathy. Evidence regarding long-term success following the procedure is limited. Also, the influence of age and preoperative performance level, are incompletely understood. The aim of this study was to investigate whether APR translates into sustained pain relief over a long-term follow-up in athletes undergoing APR. Furthermore, we analyzed if age influences clinical and functional outcome measures in APR...
November 22, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29158272/combination-antibiotic-exposure-selectively-alters-the-development-of-vancomycin-intermediate-resistance-in-staphylococcus-aureus
#19
Xuting Zheng, Andrew D Berti, Sue McCrone, Melanie Roch, Adriana E Rosato, Warren E Rose, Baiyi Chen
Invasive methicillin-resistant Staphylococcus aureus (MRSA) treated with vancomycin (VAN) is associated with reduced VAN susceptibility and treatment failure. VAN combination therapy is one strategy to improve response, but comprehensive assessments of combinations to prevent resistance are limited. This study identifies optimal combinations to prevent the emergence of VAN-intermediate Staphylococcus aureus (VISA). Two standard MRSA and two heterogeneous VISA (hVISA) strains were exposed for 28 days in vitro to VAN alone, VAN with cefazolin (CFZ), fosfomycin (FOF), gentamicin (GEN), meropenem (MEM), rifampin (RIF), piperacillin-tazobactam (TZP) or trimethoprim-sulfamethoxazole (SXT)...
November 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29155878/irhom2-is-essential-for-innate-immunity-to-rna-virus-by-antagonizing-er-and-mitochondria-associated-degradation-of-visa
#20
Wei-Wei Luo, Shu Li, Chen Li, Zhou-Qin Zheng, Pan Cao, Zhen Tong, Huan Lian, Su-Yun Wang, Hong-Bing Shu, Yan-Yi Wang
VISA (also known as MAVS, IPS-1 and Cardif) is an essential adaptor protein in innate immune response to RNA virus. The protein level of VISA is delicately regulated before and after viral infection to ensure the optimal activation and timely termination of innate antiviral response. It has been reported that several E3 ubiquitin ligases can mediate the degradation of VISA, but how the stability of VISA is maintained before and after viral infection remains enigmatic. In this study, we found that the ER-associated inactive rhomboid protein 2 (iRhom2) plays an essential role in mounting an efficient innate immune response to RNA virus by maintaining the stability of VISA through distinct mechanisms...
November 20, 2017: PLoS Pathogens
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