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https://www.readbyqxmd.com/read/28725205/school-functioning-of-a-particularly-vulnerable-group-children-and-young-people-in-residential-child-care
#1
Carla González-García, Susana Lázaro-Visa, Iriana Santos, Jorge F Del Valle, Amaia Bravo
A large proportion of the children and young people in residential child care in Spain are there as a consequence of abuse and neglect in their birth families. Research has shown that these types of adverse circumstances in childhood are risk factors for emotional and behavioral problems, as well as difficulties in adapting to different contexts. School achievement is related to this and represents one of the most affected areas. Children in residential child care exhibit extremely poor performance and difficulties in school functioning which affects their transition to adulthood and into the labor market...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28717617/conservative-treatment-for-insertional-achilles-tendinopathy-platelet-rich-plasma-and-focused-shock-waves-a-retrospective-study
#2
Davide Erroi, Matilde Sigona, Tania Suarez, Donatella Trischitta, Antonio Pavan, Maria Chiara Vulpiani, Mario Vetrano
BACKGROUND: Insertional Achilles tendinopathy (IAT) represents a serious challenge for both physiatrists and surgeons. Here we analyse the results obtained by two conservative treatments [platelet-rich plasma (PRP) injections and focused extracorporeal shock-wave therapy (ESWT)] in physically active patients with IAT. METHODS: During two consecutive periods, 45 consecutive patients with IAT were treated with 3 sessions of ESWT (2400 impulses at 0.17-0.25 mJ/mm(2) per session) (24 cases between September 2011 and July 2013) or with 2 autologous PRP injections over two weeks (21 cases between September 2013 and July 2015)...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28717616/topical-polidocanol-application-in-combination-with-static-stretching-in-tendinopathies-a-prospective-pilot-study
#3
Matthias Gatz, Simone Schrading, Timm Dirrichs, Marcel Betsch, Markus Tingart, Björn Rath, Christiane Kuhl, Valentin Quack
BACKGROUND: Highly operator-based injection therapy with vasosclerosing and anesthetic polidocanol is used for tendinopathies. This pilot-study evaluates the topical application of polidocanol gel. METHODS: Prospective case series. 39 patients with tendinopathies (14 Achilles, 14 patella, 11 wrist extensors) with a symptom duration > 6 months were included. Polidocanol and static stretching were the therapy in the first 2 weeks, while static stretching was continuously performed for 6 months...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28717615/outcomes-of-prolotherapy-for-intra-tendinous-achilles-tears-a-case-series
#4
Otto Chan, Ben Havard, Sarah Morton, Mel Pritchard, Nicola Maffulli, Tom Crisp, Nat Padhiar, Jeremy David Perry, John King, Dylan Morrissey
BACKGROUND: The intra-tendinous tear is a new pathology that is defined as a discontinuity of fibres situated entirely within the tendon. Prolotherapy involves injecting an irritant, such as hyperosmolar dextrose, to stimulate a tissue healing response and ultimately reduce pain. METHODS: 43 consecutive patients diagnosed with an intra-tendinous tear were included (27 males: 16 females, mean (SD) age 41 (11.3). Patients were injected with 0.4ml-1.5ml (mean 0.8ml) of 50% dextrose and 0...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28708705/ultrasound-guidance-does-not-improve-the-results-of-shock-wave-for-plantar-fasciitis-or-calcific-achilles-tendinopathy-a-randomized-control-trial
#5
Masiiwa M Njawaya, Bassam Moses, David Martens, Jessica J Orchard, Tim Driscoll, John Negrine, John W Orchard
OBJECTIVE: To establish whether the use of ultrasound to direct shock waves to the area of greater calcification in calcaneal enthesopathies was more effective than the common procedure of directing shock waves to the point where the patient has the most tenderness. DESIGN: Two-armed nonblinded randomized control trial with allocation concealment. SETTING: The Sports Clinic at Sydney University. PATIENTS: Participants 18 years or older with symptomatic plantar fasciitis (PF) (with heel spur) or calcific Achilles tendinopathy (CAT)...
July 11, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28693535/alfredson-versus-silbernagel-exercise-therapy-in-chronic-midportion-achilles-tendinopathy-study-protocol-for-a-randomized-controlled-trial
#6
Bas Habets, Robert E H van Cingel, Frank J G Backx, Bionka M A Huisstede
BACKGROUND: Midportion Achilles tendinopathy (AT) is a common overuse injury, usually requiring several months of rehabilitation. Exercise therapy of the ankle plantar flexors (i.e. tendon loading) is considered crucial during conservative rehabilitation. Alfredson's isolated eccentric and Silbernagel's combined concentric-eccentric exercise programs have both shown beneficial results, but it is unknown whether any of these programs is superior for use in clinical practice. Therefore, the primary objective of this study is to compare the effectiveness of both programs on clinical symptoms...
July 11, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28678925/gestational-protein-restriction-increases-cardiac-connexin-43-mrna-levels-in-male-adult-rat-offspring
#7
Kamila Fernanda Rossini, Camila Andrea de Oliveira, Hércules Jonas Rebelato, Marcelo Augusto Marreto Esquisatto, Rosana Catisti
Background: The dietary limitation during pregnancy influences the growth and development of the fetus and offspring and their health into adult life. The mechanisms underlying the adverse effects of gestational protein restriction (GPR) in the development of the offspring hearts are not well understood. Objectives: The aim of this study was to evaluate the effects of GPR on cardiac structure in male rat offspring at day 60 after birth (d60). Methods: Pregnant Wistar rats were fed a normal-protein (NP, 17% casein) or low-protein (LP, 6% casein) diet...
June 29, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28674046/repurposing-thiram-and-disulfiram-as-antibacterial-agents-for-multi-drug-resistant-staphylococcus-aureus-infections
#8
Timothy E Long
Thiram and disulfiram were evaluated as antibacterial agents against multidrug resistant Staphylococcus aureus Against a 30 member panel comprised of vancomycin-susceptible (VSSA), vancomycin-intermediate (VISA) and vancomycin-resistant (VRSA) strains, the MIC90 values of the respective test agents were 4 and 16 μg/mL. Additional analyses revealed that thiram and disulfiram are rapid-acting bacteriostatic agents with narrow, Gram-positive bacteria spectrum activity. Synergy studies further determined that disulfiram increases the vancomycin susceptibility of three clinical VRSA strains in vitro, thus establishing a potential use in combination therapy...
July 3, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28659908/pterostilbene-a-methoxylated-resveratrol-derivative-efficiently-eradicates-planktonic-biofilm-and-intracellular-mrsa-by-topical-application
#9
Shih-Chun Yang, Chih-Hua Tseng, Pei-Wen Wang, Po-Liang Lu, Yi-Han Weng, Feng-Lin Yen, Jia-You Fang
Pterostilbene is a methoxylated derivative of resveratrol originated from natural sources. We investigated the antibacterial activity of pterostilbene against drug-resistant Staphylococcus aureus and the feasibility of using it to treat cutaneous bacteria. The antimicrobial effect was evaluated using an in vitro culture model and an in vivo mouse model of cutaneous infection. The minimum inhibitory concentration (MIC) assay demonstrated a superior biocidal activity of pterostilbene compared to resveratrol (8~16-fold) against methicillin-resistant S...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28656013/vancomycin-resistance-in-staphylococcus-aureus%C3%A2
#10
REVIEW
Will A McGuinness, Natalia Malachowa, Frank R DeLeo
The evolution of Staphylococcus aureus during the modern antibiotic era has been delineated by distinct strain emergence events, many of which include acquisition of antibiotic resistance. The relative high burden of methicillin-resistant S. aureus (MRSA) in healthcare and community settings is a major concern worldwide. Vancomycin, a glycopeptide antibiotic that inhibits cell wall biosynthesis, remains a drug of choice for treatment of severe MRSA infections. S. aureus strains exhibiting increased resistance to vancomycin, known as vancomycin intermediate-resistant S...
June 2017: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/28642226/measuring-patient-reported-outcomes-pros-proms-in-people-with-achilles-tendinopathy-how-useful-is-the-visa-a
#11
EDITORIAL
Adrian Mallows, Chris Littlewood, Peter Malliaras
No abstract text is available yet for this article.
June 22, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28641800/effect-of-changes-in-visa-policies-and-procedures-on-fellows-in-training-and-early-career-cardiologists
#12
EDITORIAL
Zaher Fanari
No abstract text is available yet for this article.
June 27, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28634536/telavancin-a-novel-semisynthetic-lipoglycopeptide-agent-to-counter-the-challenge-of-resistant-gram-positive-pathogens
#13
REVIEW
Biswadeep Das, Chayna Sarkar, Debasmita Das, Amit Gupta, Arnav Kalra, Shubham Sahni
Telavancin (TD-6424), a semisynthetic lipoglycopeptide vancomycin-derivative, is a novel antimicrobial agent developed by Theravance for overcoming resistant Gram-positive bacterial infections, specifically methicillin-resistant Staphylococcus aureus (MRSA). The US Food and Drug Administration (USFDA) had approved telavancin in 2009 for the treatment of complicated skin and skin structure infections (cSSSIs) caused by Gram-positive bacteria, including MRSA (S. aureus, Streptococcus agalactiae, Streptococcus pyogenes, Streptococcus anginosus group, or Enterococcus faecalis)...
March 2017: Therapeutic Advances in Infectious Disease
https://www.readbyqxmd.com/read/28628223/unsuccessful-treatment-of-methicillin-resistant-staphylococcus-aureus-endocarditis-with-dalbavancin
#14
J M Steele, R W Seabury, C M Hale, B T Mogle
WHAT IS KNOWN AND OBJECTIVE: Limited evidence describes dalbavancin use in infective endocarditis (IE). CASE DESCRIPTION: A 27-year-old pregnant female received 4 weeks of dalbavancin for methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia and tricuspid valve IE after conventional therapy was no longer an option due to non-compliance. Despite having a smaller cardiac vegetation following dalbavancin, she was bacteraemic <2 weeks later with vancomycin-intermediate (VISA) and telavancin-non-susceptible S...
June 19, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28623258/chromatin-organization-regulates-viral-egress-dynamics
#15
Vesa Aho, Markko Myllys, Visa Ruokolainen, Satu Hakanen, Elina Mäntylä, Jori Virtanen, Veijo Hukkanen, Thomas Kühn, Jussi Timonen, Keijo Mattila, Carolyn A Larabell, Maija Vihinen-Ranta
Various types of DNA viruses are known to elicit the formation of a large nuclear viral replication compartment and marginalization of the cell chromatin. We used three-dimensional soft x-ray tomography, confocal and electron microscopy, combined with numerical modelling of capsid diffusion to analyse the molecular organization of chromatin in herpes simplex virus 1 infection and its effect on the transport of progeny viral capsids to the nuclear envelope. Our data showed that the formation of the viral replication compartment at late infection resulted in the enrichment of heterochromatin in the nuclear periphery accompanied by the compaction of chromatin...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28606105/credentialing-and-retention-of-visa-trainees-in-post-graduate-medical-education-programs-in-canada
#16
Maria Mathews, Rima Kandar, Steve Slade, Yanqing Yi, Sue Beardall, Ivy Bourgeault, Lynda Buske
BACKGROUND: Visa trainees are international medical graduates (IMG) who come to Canada to train in a post-graduate medical education (PGME) program under a student or employment visa and are expected to return to their country of origin after training. We examined the credentialing and retention of visa trainees who entered PGME programs between 2005 and 2011. METHODS: Using the Canadian Post-MD Education Registry's National IMG Database linked to Scott's Medical Database, we examined four outcomes: (1) passing the Medical Council of Canada Qualifying Examination Part 2 (MCCQE2), (2) obtaining a specialty designation (CCFP, FRCPC/SC), and (3) working in Canada after training and (4) in 2015...
June 12, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28595277/genetic-alterations-responsible-for-reduced-susceptibility-to-vancomycin-in-community-associated-mrsa-strains-of-st72
#17
Jin Yang Baek, Doo Ryeon Chung, Kwan Soo Ko, So Hyun Kim, Soo-Jin Yang, Cheol-In Kang, Kyong Ran Peck, Jae-Hoon Song
Objectives: We previously reported the first case of vancomycin treatment failure due to development of vancomycin-intermediate resistance in a patient with an MRSA of ST72, a community genotype in Korea. We investigated two isogenic MRSA strains from this patient, who experienced treatment failure with vancomycin and rifampicin. Methods: We tracked the genetic alterations that confer reduced susceptibility to vancomycin on those two isogenic MRSA strains by WGS...
June 7, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28584147/influence-of-is256-on-genome-variability-and-formation-of-scv-in-staphylococcus-aureus
#18
Franziska Kleinert, René Kallies, Michael Hort, Annegret Zweynert, Christiane Szekat, Michael Nagel, Gabriele Bierbaum
Staphylococcus aureus has acquired resistance to nearly all antibiotics used in clinical practice. Whereas some resistance mechanisms are conferred by uptake of resistance genes, others evolve by mutation. Here, the insertion sequence 256 (IS256) has been shown to play a role, e. g. in S. aureus strains displaying intermediate resistance to vancomycin (VISA).To characterize the IS256 insertion sites in the genomes of two closely related sequence type (ST) 247 VISA strains, all insertions were mapped in both VISA and a susceptible control strain...
June 5, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28582291/craniofacial-surgery-fellowship-selection-criteria-a-national-program-director-survey
#19
Francesco M Egro, Nathaniel A Blecher, Joseph E Losee, Vu T Nguyen, Jesse Goldstein
BACKGROUND: Candidate characteristics for craniofacial fellowship training still remain unknown, as no data are available in the literature. This study aims to provide information on the criteria that are used to select and rank applicants for the craniofacial surgery fellowship match. METHOD: A 38-question survey was sent in April 2015 to all craniofacial surgery fellowship program directors (n = 29) involved in the US match using QuestionPro Survey Software...
June 2, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28562450/considerations-for-residency-programs-regarding-accepting-undocumented-students-who-are-daca-recipients
#20
Sunny Nakae, Denisse Rojas Marquez, Isha Marina Di Bartolo, Raquel Rodriguez
The Deferred Action for Childhood Arrivals (DACA) initiative provides for the temporary deferral of enforcement of immigration laws for certain undocumented individuals brought to the United States before age 16. More than 50 medical schools now consider applicants who are DACA recipients, and medical school graduates with DACA are eligible to continue their training in graduate medical education. In this article, the authors summarize current policy and provide data on DACA recipients in medical school. They then review the implications for considering DACA recipients in graduate medical education, including employment guidelines, employer responsibilities, training at Veterans Affairs facilities, research funding, and professional licensure...
May 30, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
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