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George Richard Holt, Kevin Christopher McMains, Randal A Otto
Evaluating and providing global health assistance, humanitarian aid, and medical missions to Middle Eastern countries can be rewarding and challenging. A broad spectrum of financial capabilities supports effective health care delivery and infrastructure. Middle East tension can make obtaining a visa difficult. Personal safety considerations may hinder efforts to develop and carry out clinical and educational programs. Several Middle East countries have sophisticated and modern health care systems. Medical education and specialty training compares with that of Western medicine...
March 12, 2018: Otolaryngologic Clinics of North America
Ramón Medel Jiménez, Juan C Sánchez España, José Visa Nassarre, Eva Ayala Barroso, Alfredo Pueyo Ferrer, Alejandra Tapia Bahamondes, Luz M Vasquez
PURPOSE: To describe our experience and outcomes managing complete third cranial nerve palsy. METHODS: This was a retrospective analysis of the clinical records of 7 consecutive patients treated at our centre for unilateral third nerve palsy over the period 2010-2016. We describe our surgical approach using a frontalis muscle flap to correct the eyelid ptosis associated with medial fixation of the rectus muscle tendon to the orbit to correct the horizontal deviation...
March 15, 2018: Orbit
Shuaishuai Ni, Baoli Li, Feifei Chen, Hanwen Wei, Fei Mao, Yifu Liu, Yixiang Xu, Xiaoxi Qiu, Xiaokang Li, Wenwen Liu, Linghao Hu, Dazheng Ling, Manjiong Wang, Xinyu Zheng, Jin Zhu, Lefu Lan, Jian Li
Diapophytoene desaturase (CrtN) is a potential novel target for intervening in the biosynthesis of the virulence factor staphyloxanthin. In this study, 38 1,4-benzodioxan-derived CrtN inhibitors were designed and synthesized to overwhelm the defects of leading compound 4a . Derivative 47 displayed superior pigment inhibitory activity, better hERG inhibitory properties and water solubility, and significantly sensitized MRSA strains to immune clearance in vitro. Notably, 47 displayed excellent efficacy against pigmented S...
March 8, 2018: ACS Medicinal Chemistry Letters
Kota Asakura, Takuya Azechi, Hiroshi Sasano, Hidehito Matsui, Hideaki Hanaki, Motoyasu Miyazaki, Tohru Takata, Miwa Sekine, Tomoiku Takaku, Tomonori Ochiai, Norio Komatsu, Keigo Shibayama, Yuki Katayama, Koji Yahara
Vancomycin-intermediately resistant Staphylococcus aureus (VISA) and heterogeneous VISA (hVISA) are associated with treatment failure. hVISA contains only a subpopulation of cells with increased minimal inhibitory concentrations, and its detection is problematic because it is classified as vancomycin-susceptible by standard susceptibility testing and the gold-standard method for its detection is impractical in clinical microbiology laboratories. Recently, a research group developed a machine-learning classifier to distinguish VISA and hVISA from vancomycin-susceptible S...
2018: PloS One
Franz Alois Adlmann, Jörg Herbel, Airidas Korolkovas, Andreas Bliersbach, Boris Toperverg, Walter van Herck, Gunnar Karl Pálsson, Brian Kitchen, Max P W Wolff
Grazing incidence neutron scattering experiments offer surface sensitivity by reflecting from an interface at momentum transfers close to total external reflection.
 Under these conditions the penetration depth is strongly non-linear and may change by many orders of magnitude.
 This fact imposes severe challenges for depth resolved experiments, since the brilliance of neutron beams is relatively low in comparison to e.g. synchrotron radiation.
 In this article we use probability density functions to calculate the contribution of scattering at different distances from an interface to the intensities registered on the detector...
March 9, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Jordi Vega, Albert Baduell, Francesc Malagelada, Jörg Allmendinger, Miki Dalmau-Pastor
BACKGROUND: Haglund syndrome is a common cause of heel pain. Risk for tendon detachment after calcaneoplasty can exist. Open Achilles tendon detachment, calcaneoplasty, bursectomy, pathologic tendon-tissue debridement, and tendon reattachment of the Achilles tendon is a common surgical management of Haglund syndrome combined with insertional Achilles tendinopathy. The aim of this study was to describe the endoscopic calcaneoplasty and anchor suture augmentation of the Achilles insertional area, and the results obtained in patients with an increased risk of Achilles tendon rupture after calcaneoplasty...
March 1, 2018: Foot & Ankle International
Fiona J Rowe, Lauren R Hepworth, Kerry L Hanna, Claire Howard
OBJECTIVE: To report and evaluate a new Vision Impairment Screening Assessment (VISA) tool intended for use by the stroke team to improve identification of visual impairment in stroke survivors. DESIGN: Prospective case cohort comparative study. SETTING: Stroke units at two secondary care hospitals and one tertiary centre. PARTICIPANTS: 116 stroke survivors were screened, 62 by naïve and 54 by non-naïve screeners. MAIN OUTCOME MEASURES: Both the VISA screening tool and the comprehensive specialist vision assessment measured case history, visual acuity, eye alignment, eye movements, visual field and visual inattention...
March 6, 2018: BMJ Open
Samantha E Smith, Victoria R Tallentire, Lindsey M Pope, Anita H Laidlaw, Jill Morrison
OBJECTIVES: To explore the reasons that doctors choose to leave UK medicine after their foundation year two posts. SETTING: All four regions of Scotland. PARTICIPANTS: Foundation year two doctors (F2s) working throughout Scotland who were considering leaving UK medicine after foundation training were recruited on a volunteer basis. Maximum variation between participants was sought. PRIMARY AND SECONDARY OUTCOME MEASURES: Semistructured interviews were coded using template analysis...
March 2, 2018: BMJ Open
Yavuz Selim Karatekin, Bedri Karaismailoglu, Gokhan Kaynak, Tahir Ogut, Atilla Suleyman Dikici, Emel Ure Esmerer, Onder Aydingoz, Huseyin Botanlioglu
BACKGROUND: Achilles tendon injuries are one of the most common tendon injuries. Surgical treatment is preferred in young and active patients. Although there are studies which evaluate the repair area with magnetic resonance imaging and ultrasonography after surgical treatment, there are very few studies which analyzes the elasticity of the tendon by quantitative methods. ARFI (acoustic radiation force impulse) elastography is a simple and non-invasive method that can quantitatively measure the elasticity of the soft tissues...
March 2, 2018: Journal of Orthopaedic Surgery and Research
Maryam Ghahremani, Nima Hosseini Jazani, Yaeghob Sharifi
OBJECTIVES: This study aimed to evaluate the frequency, the, phenotypic and molecular characteristics of methicillin- resistant, Staphylococcus aureus (MRSA) and vancomycin-resistant S. aureus (VRSA), from clinical specimens at three university teaching hospitals in Urmia-North West of Iran (2012- 2015). METHODS: After identification of the isolates, the antibiotic, susceptibility, the presence of mecA, vanA, pvl genes and staphylococcal, cassette chromosome mec (SCCmec) typing were evaluated...
February 14, 2018: Journal of Global Antimicrobial Resistance
Jackson R Staggers, Kenneth Smith, Cesar de C Netto, Sameer Naranje, Krishna Prasad, Ashish Shah
BACKGROUND: Several operative techniques exist for Achilles tendinopathy. The purpose of our study was to compare the clinical and functional outcomes of flexor hallucis longus (FHL) transfer and V-Y advancement for the treatment of chronic insertional Achilles tendinopathy. METHODS: Retrospective chart review from 2010 to 2016 of patients that underwent FHL transfer or V-Y advancement for chronic insertional Achilles tendinopathy. Outcome measures were compared for these two procedures...
February 16, 2018: International Orthopaedics
Elinor Warner, Rogan Corbridge
Direct oesophagoscopy is largely a diagnostic procedure performed for a variety of symptoms (e.g. unilateral otalgia or odonophagia) or as part of a panendoscopy to exclude a synchronous primary; therefore good visualisation of abnormal mucosa is essential. The current standard oesophagoscopy technique involves direct visualisation from approximately 25cm down a narrow, illuminated oesophagoscope limiting visualisation of abnormal mucosa. Usually performed by a single operator, the technique is difficult to teach, as the trainee is unable to visualise what the trainer is seeing endoluminally and visa versa...
February 12, 2018: Clinical Otolaryngology
M L Plinsinga, B K Coombes, R Mellor, P Nicolson, A Grimaldi, P Hodges, K Bennell, B Vicenzino
BACKGROUND: Gluteal tendinopathy is the most common lower limb tendinopathy presenting to general practice. It has a high prevalence among middle-aged females and impacts on daily activities, work participation and quality of life. The aim was to compare physical and psychological characteristics between subgroups of severity of pain and disability. METHODS: A multi-centre cross-sectional cohort of 204 participants (mean age 55 years, 82% female) who had a clinical diagnosis of gluteal tendinopathy with MRI confirmation were assessed...
February 9, 2018: European Journal of Pain: EJP
Avi Rubinov, Hila Zommer, Helya Aghazadeh, Ezekiel Weis
OBJECTIVE: To report the experience of a tertiary care orbital service in treating severe active thyroid related orbitopathy with methotrexate (MTX) managed by the Ophthalmologist. DESIGN: Retrospective consecutive case series. PARTICIPANTS: Nineteen consecutive patients (5 males and 14 females) with severe active thyroid related orbitopathy. METHODS: Severe active thyroid orbitopathy patients with partial or no response to intravenous glucocorticoids were treated with MTX and observed for inflammatory scale reduction and treatment complications...
February 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Izabela Błażewicz, Maciej Jaśkiewicz, Lidia Piechowicz, Damian Neubauer, Roman J Nowicki, Wojciech Kamysz, Wioletta Barańska-Rybak
Introduction: Daptomycin is a cyclic lipopeptide that is bactericidal against Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), vancomycin-intermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA) strains. Daptomycin exerts its antimicrobial effect by a calcium-dependent interaction with the cytoplasmic membrane resulting in depolarization, ion loss and rapid cell death. Unfortunately, loss of daptomycin susceptibility in S. aureus in the clinical setting has been noted...
December 2017: Postȩpy Dermatologii i Alergologii
Håkan Alfredson, Christoph Spang
BACKGROUND: Non-invasive treatment is not always successful in patients with Achilles tendon disorders, and surgical treatment is instituted as the next step. There is sparse knowledge about the diagnoses, pain levels before surgery, surgically confirmed pathologies and postoperative complications in large patient groups. AIMS: To study the diagnoses, pain scores before surgery, macroscopic surgical findings and postoperative complications in a series of patients treated for Achilles disorders...
June 12, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
Lee-Chung Lin, Shih-Cheng Chang, Mao-Cheng Ge, Tsui-Ping Liu, Jang-Jih Lu
Prolonged vancomycin usage may cause methicillin-resistant Staphylococcus aureus to become vancomycin-intermediate S. aureus (VISA) and heterogeneous VISA (hVISA). Mechanisms of vancomycin resistance of VISA and hVISA are still unclear. In this study, analyses of nucleotide sequence variations in 30 vancomycin-sensitive S. aureus (VSSA), 41 hVISA and 16 VISA isolates revealed 29 single-nucleotide variations in 12 genes (fmtC, graR, graS, htrA, mecA, pbp2, pbp4, srtA, tcaA, upps, vicK and vraR) that are related to cell wall synthesis or the two-component system...
2018: Infection and Drug Resistance
Inger Sierevelt, Maayke van Sterkenburg, Hans Tol, Bella van Dalen, Niek van Dijk, Daniel Haverkamp
AIM: To translate the Victorian Institute of Sports Assessment-Achilles (VISA-A) questionnaire into the Dutch language (VISA-A-NL), and to assess its reliability, validity, and applicability to non-athletes. METHODS: After translation according to a forward-backward protocol, 101 patients with complaints of Achilles tendinopathy were asked to fill out the VISA-A-NL at two time points together with visual analogue scale, the Foot and Ankle Outcome Score, and the Short Form-36 questionnaires...
January 18, 2018: World Journal of Orthopedics
Baoli Li, Shuaishuai Ni, Feifei Chen, Fei Mao, Hanwen Wei, Yifu Liu, Jin Zhu, Lefu Lan, Jian Li
Blocking the biosynthesis process of staphyloxanthin has emerged as a promising antivirulence strategy. Our previous research revealed that diapophytoene desaturase was an attractive and druggable target against infections caused by pigmented Staphylococcus aureus. Benzocycloalkane-derived compounds were effective inhibitors of diapophytoene desaturase but limited by high hERG (human Ether-a-go-go Related Gene) inhibition activity. Here, we identified a new type of benzo-hepta-containing cycloalkane derivative as diapophytoene desaturase inhibitors...
February 12, 2018: ACS Infectious Diseases
Nadine Shaanta Murshid, Elizabeth A Bowen
Immigrant women in the United States are among the groups disproportionately affected by intimate partner violence (IPV). Undocumented immigrants generally have fewer resources for coping with violence and may experience a range of personal, cultural, and immigration status-related barriers to reporting violence and accessing help. Thus, undocumented immigrant victims of IPV could benefit significantly from policies that promote access to trauma-informed services and legal options. This article applies a trauma-informed policy analysis framework to the Violence Against Women Act's immigration protections to demonstrate how the Act's U-Visa provisions and implementation practices could be improved by incorporating trauma-informed principles of trustworthiness and transparency, empowerment, choice, safety, collaboration, and intersectionality...
January 1, 2018: Violence Against Women
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