Noreen Mohsin, Devin Hunt, Jia Yan, Austin J Jabbour, Paul Nghiem, Jaehyuk Choi, Yue Zhang, Alexandra F Freeman, Jenna R E Bergerson, Stefania Dell'Orso, Kristina Lachance, Rima Kulikauskas, Loren Collado, Wenjia Cao, Justin Lack, Morgan Similuk, Bryce A Seifert, Rajarshi Ghosh, Magdalena A Walkiewicz, Isaac Brownell
IMPORTANCE: Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer. Of the patients who develop MCC annually, only 4% are younger than 50 years. OBJECTIVE: To identify genetic risk factors for early-onset MCC via genomic sequencing. DESIGN, SETTING, AND PARTICIPANTS: The study represents a multicenter collaboration between the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Institute of Allergy and Infectious Diseases (NIAID), and the University of Washington...
January 3, 2024: JAMA Dermatology