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https://www.readbyqxmd.com/read/28538846/-clinical-and-microbiological-study-of-catheter-associated-urinary-tract-infections-in-internal-medicine-services-of-a-venezuelan-university-hospital
#1
Pedro Quijada-Martínez, Ana Flores-Carrero, Indira Labrador, María Araque
Objectives: To determine the clinical and microbiological characteristics of catheter-associated urinary tract infections (CA-UTI) in patients admitted to the Internal Medicine services of the Hospital Universitario de Los Andes (HULA), Mérida, Venezuela and to establish the clonal distribution of multi-resistant Enterobacteriaceae that produce this infection. Materials and Methods: Seventy-three adult patients with bladder catheterization were studied between January and July 2015...
January 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/28535303/a-novel-goldnano-carb-test-for-rapid-phenotypic-detection-of-carbapenemases-particularly-oxa-type-in-enterobacteriaceae-pseudomonas-aeruginosa-and-acinetobacter-spp
#2
Arpasiri Srisrattakarn, Aroonlug Lulitanond, Chotechana Wilailuckana, Nicha Charoensri, Jureerut Daduang, Aroonwadee Chanawong
Objectives: To develop a simple gold nanoparticle (AuNP)-based colorimetric test, GoldNano Carb (GoldC), for detecting carbapenemase production in Gram-negative bacteria, compared with updated Carba NP (CNP) and CarbAcineto NP (CAcNP) tests by using PCR methods as gold standard. Methods: Ninety-nine carbapenemase-producing Enterobacteriaceae (CPE), Pseudomonas spp. and Acinetobacter spp. isolates and 89 non-CPE isolates were tested by the GoldC and CNP. Additionally, the CAcNP was performed in the Acinetobacter spp...
May 23, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28533245/clonal-dissemination-of-oxa-232-carbapenenase-producing-klebsiella-pneumoniae-in-neonates
#3
Dandan Yin, Dong Dong, Ke Li, Lei Zhang, Jianliang Liang, Yang Yang, Nana Wu, Yiyan Bao, Chuanqing Wang, Fupin Hu
Five OXA-232 carbapenemase-producing Klebsiella pneumoniae were isolated from neonates, belonging to the pandemic clone ST15, and co-produced blaCTX-M-15 and blaSHV-1 genes. All isolates were resistant to ertapenem (MIC>32μg/mL) and meropenem (4-8μg/mL), susceptible or intermediate to impenem (1-2μg/mL). The blaOXA-232 was located on a ColE-type transformable plasmid of 6,141 bp. To our best knowledge, this is the first report of OXA-232 carbapenemase among clinical isolates in China.
May 22, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28533001/evaluation-of-the-rapidec%C3%A2-carba-np-and-%C3%AE-carba%C3%A2-tests-for-rapid-detection-of-carbapenemase-producing-enterobacteriaceae
#4
Stefano Mancini, Nicolas Kieffer, Laurent Poirel, Patrice Nordmann
The analytical performances of the RAPIDEC CARBA NP® (bioMérieux) and the β-CARBA® (Bio-Rad) tests were evaluated for the rapid detection of any known type of carbapenemases in Enterobacteriaceae. An international collection of 149 enterobacterial isolates comprising 111 Carbapenemase-Producing Enterobacteriaceae (CPE) and 38 non-carbapenemase producers was used. CPE included 32 carbapenemase producers of class A (18 KPC-2, 1 FRI-1, 5 SME and 8 IMI), 33 of class B (13 NDM, 11 VIM and 9 IMP) and 46 of class D (15 OXA-48, 14 OXA-181, 10 OXA-204, 3 OXA-232 and 4 OXA-162)...
May 13, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28529729/characterization-of-the-novel-in1059-harbouring-vim-gene-cassette
#5
Dongguo Wang, Jinhong Yang, Meiyu Fang, Wei He, Ying Zhang, Caixia Liu, Dongsheng Zhou
BACKGROUND: VIM-type enzyme encodes the most widely acquired metallo-β-lactamases in Gram- negative bacteria. To obtain current epidemiological data for integrons from enterobacteriae in hospital, the study characterizes the genetic structure in In1059 by comparison with In846 integrons harbouring VIM gene and other class 1 integrons including In37, In62, In843 and In1021 with the aim of identifying the putative mechanisms involved integron mobilization and infer evolution of relevant integrons...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28526792/environmental-spread-of-ndm-1-producing-multi-drug-resistant-bacteria-in-dhaka-bangladesh
#6
Mohammad Aminul Islam, Moydul Islam, Rashedul Hasan, M Iqbal Hossain, Ashikun Nabi, Mahdia Rahman, Wil H F Goessens, Hubert P Endtz, Alexandria B Boehm, Shah M Faruque
Resistance to carbapenem antibiotics through the production of New Delhi Metallo-β-lactamase-1 (NDM-1) constitutes an emerging challenge in the treatment of bacterial infections. To monitor possible source of spread of these organisms in Dhaka, Bangladesh, we conducted comparative analysis of waste water samples from hospital adjacent areas (HAR) and from community areas (COM) as well as public tap water samples for the occurrence and characteristics of NDM-1 producing bacteria. Of 72 HAR samples tested 51 (71%) were positive for NDM-1-producing bacteria as evidenced by phenotypic tests and the presence of blaNDM-1 gene, compared to 5 of 41 (12...
May 19, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28522700/draft-genome-sequences-of-two-carbapenemase-producing-acinetobacter-baumannii-clinical-strains-isolated-from-albanian-and-togolese-patients
#7
Mohamed M H Abdelbary, Guy Prod'hom, Gilbert Greub, Laurence Senn, Dominique S Blanc
We report here the draft genome sequences of two multidrug-resistant Acinetobacter baumannii clinical strains, H31499 and H31506, which were isolated at the Lausanne University Hospital in 2015 from an Albanian and a Togolese patient, respectively.
May 18, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28520983/genomic-epidemiology-of-global-vim-producing-enterobacteriaceae
#8
Yasufumi Matsumura, Gisele Peirano, Rebekah Devinney, Patricia A Bradford, Mary R Motyl, Mark D Adams, Liang Chen, Barry Kreiswirth, Johann D D Pitout
Background: : International data on the molecular epidemiology of Enterobacteriaceae with VIM carbapenemases are limited. Methods: We performed short read (Illumina) WGS on a global collection of 89 VIM-producing clinical Enterobacteriaceae (2008-14). Results: VIM-producing (11 varieties within 21 different integrons) isolates were mostly obtained from Europe. Certain integrons with bla VIM were specific to a country in different species and clonal complexes (CCs) (In 87 , In 624 , In 916 and In 1323 ), while others had spread globally among various Enterobacteriaceae species (In 110 and In 1209 )...
May 16, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28520867/activity-of-ceftolozane-tazobactam-against-surveillance-and-problem-enterobacteriaceae-pseudomonas-aeruginosa-and-non-fermenters-from-the-british-isles
#9
David M Livermore, Shazad Mushtaq, Daniele Meunier, Katie L Hopkins, Robert Hill, Rachael Adkin, Aiysha Chaudhry, Rachel Pike, Peter Staves, Neil Woodford
Background: We assessed the activity of ceftolozane/tazobactam against consecutive isolates collected in the BSAC Bacteraemia Surveillance from 2011 to 2015 and against 'problem' isolates sent to the UK national reference laboratory from July 2015, when routine testing began. Methods: Susceptibility testing was by BSAC agar dilution with resistance mechanisms identified by PCR and interpretive reading. Results: Data were reviewed for 6080 BSAC surveillance isolates and 5473 referred organisms...
May 16, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28515215/an-outbreak-of-ndm-1-producing-klebsiella-pneumoniae-in-a-dutch-hospital-with-interspecies-transfer-of-the-resistance-plasmid-and-unexpected-occurrence-in-unrelated-healthcare-centers
#10
Thijs Bosch, Suzanne P M Lutgens, Mirjam H A Hermans, Peter C Wever, Peter M Schneeberger, Nicole H M Renders, Alexander C A P Leenders, Jan A J W Kluytmans, Annelot Schoffelen, Daan Notermans, Sandra Witteveen, Erik Bathoorn, Leo M Schouls
Introduction. In the Netherlands, the number of cases with New Delhi metallo-beta-lactamase (NDM)-positive Enterobacteriaceae is low. Here, we report an outbreak of NDM-1 producing Klebsiella pneumoniae in a Dutch hospital with interspecies transfer of the resistance plasmid and unexpected occurrence in other unrelated healthcare centers (HCCs).Methods. Next-generation sequencing was performed on 250 carbapenemase-producing Enterobacteriaceae isolates including 42 NDM-positive isolates obtained from 29 persons at the outbreak site...
May 17, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28515213/rapid-identification-of-five-classes-of-carbapenem-resistance-genes-directly-from-rectal-swabs-using-the-xpert%C3%A2-carba-r-assay
#11
Nicholas M Moore, Rafael Cantón, Edoardo Carretto, Lance R Peterson, Robert L Sautter, Maria M Traczewski
Carbapenemase-producing organisms (CPO) have been identified by global health leaders as an urgent threat. Detection of patients with gastrointestinal carriage of CPO is necessary to interrupt their spread within healthcare facilities. In this multi-site study, we assessed the performance of the Xpert® Carba-R test, a rapid real-time PCR (qPCR) assay that detects five families of carbapenemase genes (blaIMP, blaKPC, blaNDM, blaOXA-48, and blaVIM) directly from rectal swab specimens. Using dual swabs, specimens from 755 patients were collected and tested prospectively...
May 17, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28512626/anti-restriction-protein-klcahs-promotes-dissemination-of-carbapenem-resistance
#12
Wei Liang, Yingzhou Xie, Wei Xiong, Yu Tang, Gang Li, Xiaofei Jiang, Yuan Lu
Carbapenemase-producing Klebsiella pneumoniae (KPC) has emerged and spread throughout the world. A retrospective analysis was performed on carbapenem-resistant K. pneumoniae isolated at our teaching hospital during the period 2009-2010, when the initial outbreak occurred. To determine the mechanism(s) that underlies the increased infectivity exhibited by KPC, Multilocus Sequence Typing (MLST) was conducted. A series of plasmids was also extracted, sequenced and analyzed. Concurrently, the complete sequences of blaKPC-2-harboring plasmids deposited in GenBank were summarized and aligned...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28511381/prevalence-of-carbapenem-resistant-non-fermenting-gram-negative-bacterial-infection-and-identification-of-carbapenemase-producing-nfgnb-isolates-by-simple-phenotypic-tests
#13
Jane Esther, Diego Edwin, Uma
INTRODUCTION: Non-Fermenting Gram negative bacilli (NFGNB) are emerging multi-drug resistant pathogens causing nosocomial infections. In recent years, carbapenem resistance in NFGNB has increased due to a variety of drug resistance mechanisms, the most common being production of carbapenemases. AIM: To detect carbapenemase and metallo-β-lactamase (MBL) production in NFGNBs by four phenotypic tests and to compare the various phenotypic methods for detection of carbapenemase and MBL production in nosocomial NFGNB isolates...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28507322/rapid-susceptibility-profiling-of-carbapenem-resistant-klebsiella-pneumoniae
#14
K T Mulroney, J M Hall, X Huang, E Turnbull, N M Bzdyl, A Chakera, U Naseer, E M Corea, M J Ellington, K L Hopkins, A L Wester, O Ekelund, N Woodford, T J J Inglis
The expanding global distribution of multi-resistant Klebsiella pneumoniae demands faster antimicrobial susceptibility testing (AST) to guide antibiotic treatment. Current ASTs rely on time-consuming differentiation of resistance and susceptibility after initial isolation of bacteria from a clinical specimen. Here we describe a flow cytometry workflow to determine carbapenem susceptibility from bacterial cell characteristics in an international K. pneumoniae isolate collection (n = 48), with a range of carbapenemases...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28507112/mcr-1-and-oxa-48-in-vivo-acquisition-in-kpc-producing-escherichia-coli-after-colistin-treatment
#15
Racha Beyrouthy, Frederic Robin, Aude Lessene, Igor Lacombat, Laurent Dortet, Thierry Naas, Valérie Ponties, Richard Bonnet
The spread of mcr-1-encoding plasmids into carbapenem-resistant Enterobacteriaceae raises concerns about the emergence of untreatable bacteria. We report the acquisition of mcr-1 in a carbapenem- resistant E. coli after a 3-week course of colistin in a patient repatriated to France from Portugal. Whole-genome sequencing revealed that the KPC-producing E. coli strain acquired two plasmids, an IncL OXA-48-encoding plasmid and an IncX4 mcr-1-encoding plasmid. This is the first report of mcr-1 in carbapenemase-encoding bacteria in France...
May 15, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28506784/healthcare-personnelintestinal-colonization-with-multidrug-resistant-organisms
#16
Brooke K Decker, Anna F Lau, John P Dekker, Christine D Spalding, Ninet Sinaii, Sean Conlan, David K Henderson, Julia A Segre, Karen M Frank, Tara N Palmore
OBJECTIVES: This study aims to assess the association between patient contact and intestinal carriageof multidrug-resistant organisms (MDRO) by sampling healthcare personnel (HCP) and staff without patient contact. METHODS: For this observational study, we recruited400HCPwho worked in our 200-bed research hospitaland 400 subjectswithout patient contact between November 2013 and February 2015.Participants submitted two self-collected perirectal swabsand a questionnaire...
May 12, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28503496/prevalence-of-acquired-carbapenemase-genes-in-klebsiella-pneumoniae-by-multiplex-pcr-in-isfahan
#17
Farzin Khorvash, Mohammed Reza Yazdani, Ali Asghar Soudi, Shiva Shabani, Nirvana Tavahen
BACKGROUND: Multi-drug resistant Klebsiella pneumoniae has been considered as a serious global threat. This study was done to investigate carbapenemase producing genomes among K. pneumoniae isolates in Isfahan, Central Iran. MATERIALS AND METHODS: In a cross-sectional study from 2011 to 2012, 29 carbapenem resistant (according to disc diffusion method) carbapenemase producing (according to modified Hodge test) K. pneumoniae strains were collected from Intensive Care Unit (ICUs) of Al-Zahra referral Hospital...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28502395/multicenter-evaluation-of-the-rapidec%C3%A2-carba-np-test-for-rapid-screening-of-carbapenemase-producing-enterobacteriaceae-and-gram-negative-nonfermenters-from-clinical-specimens
#18
Marco Coppi, Alberto Antonelli, Tommaso Giani, Teresa Spanu, Flora Marzia Liotti, Carla Fontana, Walter Mirandola, Raffaele Gargiulo, Agostino Barozzi, Carola Mauri, Luigi Principe, Gian Maria Rossolini
The rapid diagnosis of carbapenemase-producing (CP) bacteria is essential for the management of therapy and infection control. In this study, RAPIDEC® CARBA NP (RCNP) was evaluated for the rapid screening of CP Enterobacteriaceae, Acinetobacter baumannii complex, and Pseudomonas aeruginosa from clinical specimens collected at five Italian hospitals. Firstly, each site tested 20 well-characterized strains in a blinded fashion. Secondly, each center prospectively tested 25 isolates from blood cultures processed with a rapid workflow (6h after subculture) and 25 isolates from other specimens processed after an overnight culture...
April 27, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28498924/major-role-of-pkpqil-like-plasmids-in-the-early-dissemination-of-kpc-type-carbapenemases-in-the-uk
#19
M Doumith, J Findlay, H Hirani, K L Hopkins, D M Livermore, A Dodgson, N Woodford
Objectives: Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae were first seen in the UK in 2003 and have been increasingly reported since 2010, largely owing to an ongoing outbreak in North-West England. We examined the role of clonal spread and plasmid transmission in their emergence. Methods: : Isolates comprised KPC-positive K. pneumoniae ( n  =   33), Escherichia coli ( n  =   7) and Enterobacter spp. ( n  =   4) referred to the national reference laboratory between 2008 and 2010 from 17 UK centres, including three in North-West England...
May 11, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28487209/molecular-characterisation-of-carbapenemases-in-urban-pigeon-droppings-in-france-and-algeria
#20
Houda Morakchi, Lotfi Loucif, Djamila Gacemi-Kirane, Jean-Marc Rolain
OBJECTIVES: The main objective of this study was to detect the presence of carbapenemase-encoding genes in stool samples of urban pigeons. METHODS: Stool samples were collected from 73 pigeons in two Mediterranean cities, namely Marseille (France) and Annaba (Algeria). Faecal samples were screened by real-time PCR and standard PCR for the presence of carbapenemase-encoding genes. RESULTS: Carbapenem resistance genes were detected in 16 (21...
May 6, 2017: Journal of Global Antimicrobial Resistance
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