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https://www.readbyqxmd.com/read/28320165/hla-genotype-as-a-marker-of-multiple-sclerosis-prognosis-a-pilot-study
#1
Andreas P Lysandropoulos, Nicolas Mavroudakis, Massimo Pandolfo, Kaoutar El Hafsi, Wim van Hecke, Anke Maertens, Thibo Billiet, Annemie Ribbens
OBJECTIVE: The identification of a biomarker with prognostic value is an unmet need in multiple sclerosis (MS). The objective of this study was to investigate a possible association of HLA genotype with disease status and progression in MS, based on comprehensive and sensitive clinical and magnetic resonance imaging (MRI) parameters to measure disease effects. METHOD: A total of 118 MS patients (79 females, 39 males) underwent HLA typing. Patient MS status was assessed at two time points in a 2-year interval, based on clinical scores (including EDSS, MSSS, T25FW, 9-HPT, SDMT, BVMT, CVLT-II) and MRI evaluations...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28297591/estrogen-replacement-improves-verbal-memory-and-executive-control-in-oligomenorrheic-amenorrheic-athletes-in-a-randomized-controlled-trial
#2
Charumathi Baskaran, Brooke Cunningham, Franziska Plessow, Vibha Singhal, Ryan Woolley, Kathryn E Ackerman, Meghan Slattery, Hang Lee, Elizabeth A Lawson, Kamryn Eddy, Madhusmita Misra
OBJECTIVE: Both estrogen and exercise may have cognition enhancing benefits; however, young oligomenorrheic/amenorrheic athletes (OA) with estrogen deficiency have not been evaluated for cognitive deficits. Our objective was to determine whether 6 months of estrogen replacement will impact cognitive domains in OA. We hypothesized that estrogen replacement would improve verbal memory and executive control in OA. METHODS: We performed cognitive assessments at baseline and after 6 months in 48 OA (14-25 years) randomized to estrogen (EST+) (oral 30 µg ethinyl estradiol [n = 16] or transdermal 100 µg 17-β-estradiol patch [n = 13]) or no estrogen (EST-) (n = 19) in an ongoing clinical trial...
March 14, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28273777/remote-assessment-of-verbal-memory-in-ms-patients-using-the-california-verbal-learning-test
#3
Lisa F Barcellos, Kalliope H Bellesis, Ling Shen, Xiaorong Shao, Terrence Chinn, Seth Frndak, Allison Drake, Nandini Bakshi, Jackie Marcus, Catherine Schaefer, Ralph Hb Benedict
We used the California Verbal Learning Test, Second Edition (CVLT-II), one component of the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS), to determine feasibility of a remote assessment protocol. We compared telephone-administered CVLT-II data from MS patients to data acquired in person from an independent sample of patients and healthy controls. Mixed factor analyses of variance (ANOVAs) showed no significant differences between patient groups, but between-group effects comparing patients and healthy controls were significant...
February 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28111742/the-role-of-executive-functioning-in-memory-performance-in-pediatric-focal-epilepsy
#4
Leigh N Sepeta, Kaitlin Blackstone Casaletto, Virginia Terwilliger, Joy Facella-Ervolini, Maegan Sady, Jessica Mayo, William D Gaillard, Madison M Berl
OBJECTIVE: Learning and memory are essential for academic success and everyday functioning, but the pattern of memory skills and its relationship to executive functioning in children with focal epilepsy is not fully delineated. We address a gap in the literature by examining the relationship between memory and executive functioning in a pediatric focal epilepsy population. METHODS: Seventy children with focal epilepsy and 70 typically developing children matched on age, intellectual functioning, and gender underwent neuropsychological assessment, including measures of intelligence (Wechsler Abbreviated Scale of Intelligence [WASI]/Differential Ability Scales [DAS]), as well as visual Children's Memory Scale (CMS Dot Locations) and verbal episodic memory (Wide Range Assessment of Memory and Learning [WRAML] Story Memory and California Verbal Learning Test for Children [CVLT-C])...
February 2017: Epilepsia
https://www.readbyqxmd.com/read/28071963/impaired-verbal-learning-in-forensic-inpatients-with-schizophrenia-spectrum-disorder
#5
Lasha Corbett, Kenny A Karyadi, Dominique Kinney, Stephen R Nitch, Stacey Marie Bayan, Mark Williams
The present study aimed to: (a) examine verbal learning performances among forensic inpatients diagnosed with Schizophrenia Spectrum Disorder (SSD); and (b) compare verbal learning performances among forensic SSD inpatients, SSD outpatients, and a small control sample. Participants included forensic SSD inpatients (n = 71), SSD outpatients (n = 305; see Stone et al.), and a control sample from the California Verbal Learning Test-II (CVLT-II) manual (n = 78; see Delis, Kramer, Kaplan, & Ober). Five verbal learning outcomes were measured using the CVLT-II...
January 10, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/27991994/the-correlation-between-edss-and-cognitive-impairment-in-ms-patients-assessment-of-a-brazilian-population-using-a-bicams-version
#6
Marco A G de Caneda, Maria Cecília A de Vecino
Objectives: To investigate the correlation between the disabilities of MS patients and their cognitive impairment assessed by the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS). Methods: Forty patients with definitive diagnoses of MS were selected. The correlation coefficient (r) between the Expanded Disability Status Scale (EDSS) and the neuropsychological tests of BICAMS were calculated. Results: The correlation was clinically substantial and significant with r = 0...
December 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27984258/incidental-learning-a-brief-valid-measure-of-memory-based-on-the-wais-iv-vocabulary-and-similarities-subtests
#7
Robert J Spencer, Jaclyn Reckow, Lauren L Drag, Linas A Bieliauskas
OBJECTIVE: We assessed the validity of a brief incidental learning measure based on the Similarities and Vocabulary subtests of the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV). BACKGROUND: Most neuropsychological assessments for memory require intentional learning, but incidental learning occurs without explicit instruction. Incidental memory tests such as the WAIS-III Symbol Digit Coding subtest have existed for many years, but few memory studies have used a semantically processed incidental learning model...
December 2016: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/27920794/dance-experience-and-associations-with-cortical-gray-matter-thickness-in-the-aging-population
#8
Shai Porat, Naira Goukasian, Kristy S Hwang, Theodore Zanto, Triet Do, Jonathan Pierce, Shantanu Joshi, Ellen Woo, Liana G Apostolova
INTRODUCTION: We investigated the effect dance experience may have on cortical gray matter thickness and cognitive performance in elderly participants with and without mild cognitive impairment (MCI). METHODS: 39 cognitively normal and 48 MCI elderly participants completed a questionnaire regarding their lifetime experience with music, dance, and song. Participants identified themselves as either dancers or nondancers. All participants received structural 1.5-tesla MRI scans and detailed clinical and neuropsychological evaluations...
September 2016: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/27889837/exercise-training-effects-on-memory-and-hippocampal-viscoelasticity-in-multiple-sclerosis-a-novel-application-of-magnetic-resonance-elastography
#9
Brian M Sandroff, Curtis L Johnson, Robert W Motl
INTRODUCTION: Cognitive impairment is common and debilitating among persons with multiple sclerosis (MS) and might be managed with exercise training. However, the effects of exercise training on viscoelastic brain properties in this population are unknown. The present pilot study adopted a single-blind randomized controlled trial (RCT) design and is the first to examine the effect of an aerobic exercise training intervention on learning and memory and hippocampal viscoelasticity using magnetic resonance elastography (MRE) in persons with MS...
November 26, 2016: Neuroradiology
https://www.readbyqxmd.com/read/27885448/cognitive-dysfunction-in-patients-with-multiple-sclerosis-treated-with-first-line-disease-modifying-therapy-a-multi-center-controlled-study-using-the-bicams-battery
#10
MULTICENTER STUDY
Bilge Piri Cinar, Görkem Kösehasanoğulları, Pinar Yigit, Serkan Ozakbas
Multiple sclerosis (MS) can impair cognitive functions even in the early stages. The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) battery is very short and highly sensitive and can be used to evaluate cognitive status in the disease. Several clinical trials have shown beneficial effects of disease-modifying drugs (DMDs) on long-term cognitive measures which may even reduce cognitive deficits in MS patients. Relapsing remitting MS patients using DMDs were enrolled in the study and monitored for 12 months...
February 2017: Neurological Sciences
https://www.readbyqxmd.com/read/27827539/exploratory-analysis-of-cvlt-ii-forced-choice-recognition-and-rbans-ei-base-rates-for-forensically-committed-psychotic-disordered-inpatients-implications-on-clinical-decision-making
#11
Stacey M Bayan, Steve Nitch, Dominique Kinney, Marina Kaminetskaya
Within the inpatient forensic setting, requests for a neuropsychological evaluation are common to determine cognitive strengths and weaknesses. However, variable effort proves to be a prominent issue in this setting. Thus, assessment of effort becomes an essential component of a neuropsychological evaluation. The California Verbal Learning Test, 2nd Edition (CVLT-II) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) are widely utilized cognitive measures in the inpatient setting...
November 9, 2016: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/27826691/drd2-c957t-polymorphism-is-associated-with-improved-6-month-verbal-learning-following-traumatic-brain-injury
#12
John K Yue, Ethan A Winkler, Jonathan W Rick, John F Burke, Thomas W McAllister, Sam S Oh, Esteban G Burchard, Donglei Hu, Jonathan Rosand, Nancy R Temkin, Frederick K Korley, Marco D Sorani, Adam R Ferguson, Hester F Lingsma, Sourabh Sharma, Caitlin K Robinson, Esther L Yuh, Phiroz E Tarapore, Kevin K W Wang, Ava M Puccio, Pratik Mukherjee, Ramon Diaz-Arrastia, Wayne A Gordon, Alex B Valadka, David O Okonkwo, Geoffrey T Manley
Traumatic brain injury (TBI) often leads to heterogeneous clinical outcomes, which may be influenced by genetic variation. A single-nucleotide polymorphism (SNP) in the dopamine D2 receptor (DRD2) may influence cognitive deficits following TBI. However, part of the association with DRD2 has been attributed to genetic variability within the adjacent ankyrin repeat and kinase domain containing 1 protein (ANKK1). Here, we utilize the Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot (TRACK-TBI Pilot) study to investigate whether a novel DRD2 C957T polymorphism (rs6277) influences outcome on a cognitive battery at 6 months following TBI-California Verbal Learning Test (CVLT-II), Wechsler Adult Intelligence Test Processing Speed Index Composite Score (WAIS-PSI), and Trail Making Test (TMT)...
January 2017: Neurogenetics
https://www.readbyqxmd.com/read/27780496/cognitive-and-anatomical-correlates-of-anosognosia-in-amnestic-mild-cognitive-impairment-and-early-stage-alzheimer-s-disease
#13
Gulben Senturk, Basar Bilgic, Ali Bilgin Arslan, Ali Bayram, Hasmet Hanagasi, Hakan Gurvit, Murat Emre
BACKGROUND: Anosognosia is a common feature in Alzheimer's disease (AD). The brain substrates of anosognosia are not fully understood, and less is known about the cognitive substrates of anosognosia in prodromal and early stages of AD. METHODS: Fourty-seven patients with amnestic-type mild cognitive impairment (aMCI) (n = 26) and early-stage AD (n = 21) were included, and Clinical Insight Rating Scale and Anosognosia Questionnaire for Dementia (AQ-D) were used to assess anosognosia...
October 26, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27753292/trying-to-remember-effort-mediates-the-relationship-between-frequency-of-cannabis-use-and-memory-performance
#14
Rayna B Hirst, Kaitlyn R Young, Louise M Sodos, Robert E Wickham, Mitch Earleywine
INTRODUCTION: While many studies suggest that regular cannabis use leads to deficits in cognitive functioning, particularly in memory, few have measured effort put forth during testing, and none have examined this as a potential mediator. Both age of onset of regular cannabis use and frequency of use have been linked to increased risk of memory deficits. The present study sought to determine whether effort mediated the relationship between frequency or age of onset of cannabis use and learning and memory performance...
October 18, 2016: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/27744302/the-relative-temporal-sequence-of-decline-in-mobility-and-cognition-among-initially-unimpaired-older-adults-results-from-the-baltimore-longitudinal-study-of-aging
#15
Qu Tian, Yang An, Susan M Resnick, Stephanie Studenski
BACKGROUND: most older individuals who experience mobility decline, also show cognitive decline, but whether cognitive decline precedes or follows mobility limitation is not well understood. OBJECTIVE: examine the temporal sequence of mobility and cognition among initially unimpaired older adults. METHODS: mobility and cognition were assessed every 2 years for 6 years in 412 participants aged ≥60 with initially unimpaired cognition and gait speed...
October 15, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27668977/a-new-assessment-tool-for-patients-with-multiple-sclerosis-from-spanish-speaking-countries-validation-of-the-brief-international-cognitive-assessment-for-ms-bicams-in-argentina
#16
Sandra Vanotti, Audrey Smerbeck, Ralph H B Benedict, Fernando Caceres
BACKGROUND: The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) is an international assessment tool for monitoring cognitive function in multiple sclerosis (MS) patients. BICAMS comprises the Symbol Digit Modalities Test (SDMT), the California Verbal Learning Test - Second Edition (CVLT II) and the Brief Visuospatial Memory Test - Revised (BVMT-R). Our objective was to validate and assess the reliability of BICAMS as applied in Argentina and to obtain normative data in Spanish for this population...
October 2016: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/27658720/improvement-in-verbal-memory-performance-in-depressed-in-patients-after-treatment-with-electroconvulsive-therapy
#17
S V Biedermann, J M Bumb, T Demirakca, G Ende, A Sartorius
OBJECTIVE: Electroconvulsive therapy (ECT) is a highly effective and well-tolerated therapy for severe and treatment-resistant depression. Cognitive side-effects are still feared by some patients and clinicians. Importantly, cognitive impairments are among the most disabling symptoms of depression itself. METHODS: Patients suffering from a severe episode of depression were treated with either ECT or treatment as usual (TAU) in an in-patient setting. Matched healthy participants served as controls (HC)...
December 2016: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/27645348/validation-of-the-brief-international-cognitive-assessment-for-multiple-sclerosis-bicams-in-greek-population-with-multiple-sclerosis
#18
E Polychroniadou, C Bakirtzis, D Langdon, R Lagoudaki, E Kesidou, P Theotokis, D Tsalikakis, K Poulatsidou, O Kyriazis, M Boziki, G Papadopoulos, E Boura, L Sintila, S Hatzigeorgiou, C Ziamos, P Ioannidis, D Karacostas, N Grigoriadis
BACKGROUND: Cognitive impairment is experienced by about 50% of patients with Multiple Sclerosis (MS) worldwide and affects their employment, disease management and quality of life in general. The Brief International Cognitive assessment for MS (BICAMS) is a brief, practical and potentially universal battery for cognitive impairment in MS patients. It consists of three tests: the Symbol Digit Modalities Test (SDMT), the California Verbal Learning Test-2 (CVLT-2) and the Brief Visuospatial Memory Test-Revised (BVMT-R)...
September 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27619108/cvlt-ii-forced-choice-recognition-trial-as-an-embedded-validity-indicator-a-systematic-review-of-the-evidence
#19
Eben S Schwartz, Laszlo Erdodi, Nicholas Rodriguez, Jyotsna J Ghosh, Joshua R Curtain, Laura A Flashman, Robert M Roth
OBJECTIVES: The Forced Choice Recognition (FCR) trial of the California Verbal Learning Test, 2nd edition, was designed as an embedded performance validity test (PVT). To our knowledge, this is the first systematic review of classification accuracy against reference PVTs. METHODS: Results from peer-reviewed studies with FCR data published since 2002 encompassing a variety of clinical, research, and forensic samples were summarized, including 37 studies with FCR failure rates (N=7575) and 17 with concordance rates with established PVTs (N=4432)...
September 2016: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/27595167/intrusions-and-provoked-and-spontaneous-confabulations-on-memory-tests-in-korsakoff-s-syndrome
#20
Yvonne C M Rensen, Joukje M Oosterman, Serge J W Walvoort, Paul A T M Eling, Roy P C Kessels
INTRODUCTION: Intrusions on verbal memory tests have been used as an index for clinical confabulation. Severe memory impairments in combination with executive dysfunction have been suggested to be the underlying mechanism of confabulation, but to date, this relation is unclear. The aim of this study was (a) to examine the relation between (different types of) intrusions and confabulations in a large sample of confabulating patients with Korsakoff's syndrome (KS) and (b) to investigate whether different measures of executive functioning and memory performance are related to provoked and spontaneous confabulation...
March 2017: Journal of Clinical and Experimental Neuropsychology
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