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https://www.readbyqxmd.com/read/28060449/therapeutic-effects-of-drug-switching-between-acetylcholinesterase-inhibitors-in-patients-with-alzheimer-s-disease
#1
Yasuyuki Ohta, Mohamed Darwish, Nozomi Hishikawa, Toru Yamashita, Kota Sato, Mami Takemoto, Koji Abe
AIM: To evaluate the therapeutic effects of switching from one acetylcholinesterase inhibitor (ChEI), donepezil, galantamine or rivastigmine, to another in Alzheimer's disease patients. METHODS: We retrospectively enrolled 171 Alzheimer's disease patients, whose ChEI medication was changed. The patients were evaluated on three major aspects of dementia - cognitive, affective and activities of daily living (ADL) measures - at 6 months (M) before the drug switch, at the time of drug switch (baseline), and at 3 M and 6 M after the drug switch...
January 6, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28049192/combined-memantine-and-donepezil-treatment-improves-behavioral-and-psychological-symptoms-of-dementia-like-behaviors-in-olfactory-bulbectomized-mice
#2
Yasushi Yabuki, Kazuya Matsuo, Koga Hirano, Yasuharu Shinoda, Shigeki Moriguchi, Kohji Fukunaga
Memantine, an uncompetitive N-methyl-D-aspartate receptor antagonist, and the cholinesterase inhibitor, donepezil, are approved in most countries for treating moderate-to-severe Alzheimer's disease (AD). These drugs have different molecular targets; thus, it is expected that the effects of combined treatment would be synergistic. Some reports do show memantine/donepezil synergy in ameliorating cognition in AD model animals, but their combined effects on behavioral and psychological symptoms of dementia (BPSD)-like behaviors have not been addressed...
January 4, 2017: Pharmacology
https://www.readbyqxmd.com/read/28035924/the-effect-of-the-association-between-donepezil-and-choline-alphoscerate-on-behavioral-disturbances-in-alzheimer-s-disease-interim-results-of-the-ascomalva-trial
#3
Anna Carotenuto, Raffaele Rea, Enea Traini, Angiola Maria Fasanaro, Giovanna Ricci, Valentino Manzo, Francesco Amenta
BACKGROUND: Behavioral and psychological symptoms of dementia (BPSD) are a group of psychological reactions, psychiatric symptoms, and behaviors commonly found in Alzheimer's disease (AD). Four clusters of BPSD have been described: mood disorders (depression, anxiety, and apathy), psychotic symptoms (delusions and hallucinations), aberrant motor behaviors (pacing, wandering, and other purposeless behaviors), and inappropriate behaviors (agitation, disinhibition, and euphoria). Most of them are attributed to acetylcholine deficiency...
December 30, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28009676/effectiveness-of-meaningful-occupation-interventions-for-people-living-with-dementia-in-residential-aged-care-a-systematic-review
#4
Catherine Travers, Deborah Brooks, Sonia Hines, Maria O'Reilly, Mitchell McMaster, Wei He, Margaret MacAndrew, Elaine Fielding, Lina Karlsson, Elizabeth Beattie
BACKGROUND: The ability to participate in valued activities, whether for work, leisure or family, is an important aspect of personal identity. In dementia, progressive memory loss means that abilities developed over a lifetime begin to be lost as well, contributing to the loss of self and identity. Some studies have reported that activities or interventions tailored to be meaningful to the person with dementia (defined as any activity important to the individual) are more effective in addressing behavioral and psychological symptoms of dementia (BPSD) and improving quality of life (QoL) than those that are not so tailored...
December 2016: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28009620/the-treatment-of-disruptive-vocalization-in-dementia-behavioral-and-psychological-symptoms-of-dementia-with-electroconvulsive-therapy-a-case-series
#5
Timothy Edwin Lau, Prakash Kishor Babani, Lisa Anne McMurray
OBJECTIVE: There is emerging evidence that electroconvulsive therapy (ECT) can help with the behavioral and psychological symptoms of dementia. One of the most distressing behavioral symptoms of dementia is disruptive vocalization. Previous small case series have suggested that antidepressants and ECT can be beneficial for this distressing condition. The aim of this study was to describe the successful use of ECT in treating 5 patients with disruptive vocalization. METHODS: A retrospective chart review of 5 patients with dementia of mixed etiologies was conducted comparing pretreatment and posttreatment scores on the Cohen-Mansfield Agitation Inventory...
December 21, 2016: Journal of ECT
https://www.readbyqxmd.com/read/28001283/hey-mister-tambourine-man-play-a-drug-for-me-music-as-medication
#6
Robert H Howland
Listening to music may be thought of as noninvasive and nonpharmacological, but music should be considered a drug therapy. Music exposure has measurable neurobiological effects that are linked to systems regulating reward, motivation, and pleasure; stress and arousal; and immunity. Functional neuroimaging and lesion studies demonstrate that music-evoked emotions are associated with modulation of linked limbic and paralimbic brain regions. Some of these regions are involved in reward, motivation, and pleasure, and there are additional projections to brain structures regulating autonomic, emotional, and cognitive function...
December 1, 2016: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/27998324/investigating-the-current-methods-of-assessing-behavioral-and-psychological-symptoms-in-residential-aged-care-facilities-in-a-metropolitan-city
#7
Samantha M Loi, Nicola T Lautenschlager
Up to 90% of people with dementia living in residential aged care facilities (RACFs) display behavioral and psychological symptoms of dementia (BPSD), and these are associated with poorer quality of life and increased morbidity and mortality. In order to implement appropriate interventions, it is important to understand the symptoms in more detail. Despite the availability of BPSD assessment tools, it is unknown what the current practice of monitoring of BPSD in RACFs. We sought to investigate the current BPSD assessment tools being used in RACFs and explore different stakeholders' views on current practices...
December 21, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27970857/pharmacotherapies-for-the-treatment-of-behavioral-and-psychological-symptoms-of-dementia-a-systematic-review-on-recent-evidence
#8
H Stürzlinger, A Eisenmann, K Antony, A Laschkolnig, D Pertl
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27927732/trauma-informed-hospice-and-palliative-care
#9
Barbara L Ganzel
This review highlights the need to integrate trauma-informed practices into hospice and palliative care. The pervasiveness of psychological trauma exposure has been established in the general population and among the elderly adults. Moreover, there is emerging evidence for multiple additional opportunities for exposure to psychological trauma at or near the end of life. For example, many people experience intensive medical interventions prior to their admission to hospice and/or palliative care, and there is increasing recognition that these interventions may be traumatic...
December 7, 2016: Gerontologist
https://www.readbyqxmd.com/read/27917740/delirium-superimposed-on-dementia-phenomenological-differences-between-patients-with-and-without-behavioral-and-psychological-symptoms-of-dementia-in-a-specialized-delirium-unit
#10
Jennifer Abengaña, Mei Sian Chong, Laura Tay
BACKGROUND: Overlap between neuropsychiatric symptoms of dementia and delirium complicates diagnosis of delirium superimposed on dementia (DSD). This study sought to examine differences in delirium presentation and outcomes between DSD patients with and without pre-existing behavioral and psychological symptoms of dementia (BPSD). METHODS: This was a prospective cohort study of older adults with DSD admitted to a specialized delirium unit (December 2010-August 2012)...
December 5, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27911304/effects-of-short-term-exercise-interventions-on-behavioral-and-psychological-symptoms-in-patients-with-dementia-a%C3%A2-systematic-review
#11
Tim Fleiner, Stefan Leucht, Hans Förstl, Wiebren Zijlstra, Peter Haussermann
Observational and interventional studies indicate a direct link between the patients' physical activity and the extent of behavioral and psychological symptoms of dementia (BPSD). At present, there are no evidence-based recommendations for physical exercise in the acute dementia care settings. Hence, this systematic review investigates the effects of short-term exercise trials on BPSD. Trials with a length up to three months investigating the effects of structured exercise interventions on BPSD in acute dementia care settings were included...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27865556/trans-crocetin-improves-amyloid-%C3%AE-degradation-in-monocytes-from-alzheimer-s-disease-patients
#12
Roberto Tiribuzi, Lucia Crispoltoni, Valerio Chiurchiù, Antonella Casella, Celeste Montecchiani, Alberto Marco Del Pino, Mauro Maccarrone, Carlo Alberto Palmerini, Carlo Caltagirone, Toshitaka Kawarai, Aldo Orlacchio, Antonio Orlacchio
Herbal medicines have been recently employed in research and clinical studies for the potential treatment of behavioral and psychological symptoms associated with Alzheimer's Disease (AD) and other types of dementia. The present study investigates the effect of trans-crocetin, an active constituent of Crocus sativus L., to restore in vitro the reduced ability of AD patients' monocytes to degrade amyloid-β(1-42) (Aβ42). CD14(+) monocytes from 22 sporadic AD patients with moderate cognitive impairment were isolated; then, the role of trans-crocetin, purified from saffron extracts, was evaluated in terms of Aβ42 degradation rate through flow cytometry, as well as expression of cathepsin B by Western blotting...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27864478/patient-and-caregiver-interplay-in-behavioral-and-psychological-symptoms-of-dementia-family-caregiver-s-experience
#13
Jun-Ah Song, Myonghwa Park, Jaewon Park, Hong Jin Cheon, Mihyun Lee
The purpose of this study was to identify family caregivers' experiences in managing the behavioral and psychological symptoms of dementia (BPSD) with particular focus on their interpersonal interactions with patient with dementia. Data were collected through focus-group interviews with 15 family caregivers from three local dementia-support centers located in Seoul. Data were analyzed using content analysis. Three main themes were identified through data analysis: triggers of BPSD, family caregiver's actions in response to BPSD and patient's reactions, and the effect of BPSD on family caregivers...
November 17, 2016: Clinical Nursing Research
https://www.readbyqxmd.com/read/27849639/wecareadvisor%C3%A2-the-development-of-a-caregiver-focused-web-based-program-to-assess-and-manage-behavioral-and-psychological-symptoms-of-dementia
#14
Helen C Kales, Laura N Gitlin, Barbara Stanislawski, Katherine Marx, Molly Turnwald, Daphne C Watkins, Constantine G Lyketsos
BACKGROUND/OBJECTIVES: Behavioral and psychological symptoms of dementia (BPSD) are nearly universal in dementia and associated with multiple negative outcomes. Current real-world management is largely pharmacologic, despite poor risk/benefit. The WeCareAdvisor was designed to enable family caregivers to assess, manage, and track BPSD using nonpharmacologic strategies. DESIGN: In-depth qualitative data were collected from family caregivers of people with dementia to inform: (1) style of approach and "look and feel" of the tool, and (2) the types of psychoeducation most needed by caregivers...
November 15, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27847922/treatment-of-behavioral-and-psychological-symptoms-of-dementia-a-systematic-review
#15
REVIEW
Ulrich W Preuss, Jessica W M Wong, G Koller
BPSD (Behavioral and Psychological Symptoms in Dementia) affects virtually all patients with dementia. The aim of this review is to present information on epidemiology, consequences and evidence-based non-pharmacological and pharmacological treatment approaches. The review also covers recent literature derived from a systematic literature Medline search on BPSD. Results indicate that BPSD are major risk factors for an earlier placement of affected individuals in nursing homes and a potentially more severe course of dementia over time...
2016: Psychiatria Polska
https://www.readbyqxmd.com/read/27846102/study-on-the-effects-of-individualized-learning-therapy-on-cognitive-function-and-behavioral-and-psychological-symptoms-of-dementia-in-the-institutionalized-older-adults
#16
Hsiao-Mei Chen, Li-Jane Tsai, Shu-Yuan Chao, Mary Jo Clark
BACKGROUND: The increasing number of elderly people affected by dementia in Taiwan has made dementia care a crucial issue of concern. This issue is particularly important in terms of the proper management of behavioral symptoms and improvement of the cognitive functions of those affected by this disease. PURPOSE: This study examined the effects of individualized learning therapy on cognition and neuropsychiatric symptoms among elderly people with dementia. METHODS: A quasi-experimental, pretest-posttest research design was adopted...
December 2016: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/27806743/causes-of-nursing-home-placement-for-older-people-with-dementia-a-systematic-review-and-meta-analysis
#17
Sandeep Toot, Tom Swinson, Mike Devine, David Challis, Martin Orrell
BACKGROUND: Up to half of people with dementia in high income countries live in nursing homes and more than two-thirds of care home residents have dementia. Fewer than half of these residents report good quality of life and most older people are anxious about the prospect of moving into a nursing home. Robust evidence is needed as to the causes of admission to nursing homes, particularly where these risk factors are modifiable. METHODS: We conducted a systematic literature search to identify controlled comparison studies in which the primary outcome was admission to nursing home of older adults with dementia...
November 3, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27756815/eating-behaviors-and-dietary-changes-in-patients-with-dementia
#18
Gabriele Cipriani, Cecilia Carlesi, Claudio Lucetti, Sabrina Danti, Angelo Nuti
BACKGROUND: Eating problems and dietary changes have been reported in patients with dementia. OBJECTIVES: The aim of this article is to explore the generalized problems with nutrition, diet, feeding, and eating reported among patients with dementia. METHODS: Medline and Google Scholar searches were conducted for relevant articles, chapters, and books published before 2016. Search terms used included behavioral and psychological symptoms of dementia, dementia, dietary changes, eating behavior...
October 18, 2016: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/27743677/-prescription-of-antipsychotics-in-elderly-patients-with-dementia-in-a-psychiatric-hospital-impact-of-recommendations-of-the-french-health-authority
#19
X Jégouzo, M Desbordes, S Delègue, G Le Vacon, M Patrick, S Mouchabac
OBJECTIVES: Behavioral and psychological symptoms have a high prevalence in dementia. They include mood disorders, psychotic disorders and behavioral disorders such as aggression or screaming. Despite a number of side effects and an increased mortality, antipsychotic drugs are widely prescribed for treatment of this disorder. In France, this increased risk of mortality led in 2009 to the adoption of guidelines concerning all antipsychotics. The guidelines propose a sensible use of antipsychotics after the establishment of non-pharmacological measures...
October 12, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27726067/apathy-in-dementia-systematic-review-of-recent-evidence-on-pharmacological-treatments
#20
Fleur Harrison, Liesbeth Aerts, Henry Brodaty
Increasing recognition that apathy is one of the most prevalent behavioral and psychological symptoms of dementia and causes substantial caregiver distress has led to trials evaluating psychosocial and pharmacological treatments of apathy in dementia. We evaluated evidence of the efficacy of pharmacotherapies for apathy in dementia from studies since 2013. Previously reported benefits of acetylcholinesterase inhibitors and memantine were not replicated in recent studies. Antidepressants had mixed results with positive effects for apathy shown only for agomelatine, while stimulants, analgesics, and oxytocin study results were inconclusive...
November 2016: Current Psychiatry Reports
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