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https://www.readbyqxmd.com/read/27866152/the-effect-of-childhood-add-adhd-on-parental-workforce-participation
#1
Emily J Callander, Faith Allele, Hayley Roberts, William Guinea, Daniel B Lindsay
OBJECTIVE: This research aimed to examine the impact of attention deficit disorder (ADD)/ADHD in children on parental labor force participation across different child age groups. METHOD: This study utilized a longitudinal, quantitative analyses approach. All data were collected from Wave 6 of the Growing Up in Australia: The Longitudinal Study of Australian Children (LSAC) survey. RESULTS: After adjusting for various confounders, mothers whose children were 10/11 years old and had been diagnosed with ADD/ADHD were significantly more likely to be out of the labor force compared with those mothers whose child had not been diagnosed with ADD/ADHD...
November 19, 2016: Journal of Attention Disorders
https://www.readbyqxmd.com/read/27859951/the-effectiveness-of-therapeutic-conversation-intervention-for-caregivers-of-adolescents-with-adhd-a-quasi-experimental-design
#2
M Gisladottir, E K Svavarsdottir
: WHAT IS KNOWN ON THE SUBJECT?: Caregivers of adolescents with ADHD experience major difficulties as care providers and are in need of guidance and support. Adolescents with ADHD may develop oppositional and criminal behaviour. More than 50 % have the symptoms in adulthood, and up to one-fourth with severe emotional or antisocial difficulties. There is a lack of evidence of caregivers' supporting intervention although caregiver groups have been found to contribute to better coping, decreased stress and improvements in ADHD symptoms...
November 18, 2016: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/27828696/current-and-investigational-medication-delivery-systems-for-treating-attention-deficit-hyperactivity-disorder
#3
Rakesh Jain, Alain Katic
OBJECTIVE: To review currently available formulations and emphasize unmet needs in the pharmacologic management of attention-deficit/hyperactivity disorder (ADHD). DATA SOURCES: Publications and clinical trials were identified through PubMed and ClinicalTrials.gov, respectively. A Web-based search identified prescribing information for approved agents for treating ADHD, along with relevant guidelines and diagnostic criteria. STUDY SELECTION: The following search terms were used: (1) ADHD or attention-deficit/hyperactivity disorder or ADD or attention deficit hyperactivity disorder and/or (2) amphetamine or methylphenidate or atomoxetine or guanfacine or clonidine...
August 18, 2016: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/27754487/exome-chip-analyses-in-adult-attention-deficit-hyperactivity-disorder
#4
T Zayats, K K Jacobsen, R Kleppe, C P Jacob, S Kittel-Schneider, M Ribasés, J A Ramos-Quiroga, V Richarte, M Casas, N R Mota, E H Grevet, M Klein, J Corominas, J Bralten, T Galesloot, A A Vasquez, S Herms, A J Forstner, H Larsson, G Breen, P Asherson, S Gross-Lesch, K P Lesch, S Cichon, M B Gabrielsen, O L Holmen, C H D Bau, J Buitelaar, L Kiemeney, S V Faraone, B Cormand, B Franke, A Reif, J Haavik, S Johansson
Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable childhood-onset neuropsychiatric condition, often persisting into adulthood. The genetic architecture of ADHD, particularly in adults, is largely unknown. We performed an exome-wide scan of adult ADHD using the Illumina Human Exome Bead Chip, which interrogates over 250 000 common and rare variants. Participants were recruited by the International Multicenter persistent ADHD CollaboraTion (IMpACT). Statistical analyses were divided into 3 steps: (1) gene-level analysis of rare variants (minor allele frequency (MAF)<1%); (2) single marker association tests of common variants (MAF⩾1%), with replication of the top signals; and (3) pathway analyses...
October 18, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27690748/neurological-soft-signs-are-associated-with-attentional-dysfunction-in-children-with-attention-deficit-hyperactivity-disorder
#5
Mariabernarda Pitzianti, Elisa D'Agati, Livia Casarelli, Marco Pontis, Ivo Kaunzinger, Klaus W Lange, Oliver Tucha, Paolo Curatolo, Augusto Pasini
INTRODUCTION: Inattention is one of the core symptoms of Attention Deficit Hyperactivity Disorder (ADHD). Most of patients with ADHD show motor impairment, consisting in the persistence of neurological soft signs (NSS). Our aim was to evaluate attentional and motor functioning in an ADHD sample and healthy children (HC) and possible link between attentional dysfunction and motor impairment in ADHD. METHOD: Twenty-seven drug-naive patients with ADHD and 23 HC were tested with a test battery, measuring different aspects of attention...
October 1, 2016: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/27652281/adgrl3-lphn3-variants-are-associated-with-a-refined-phenotype-of-adhd-in-the-mta-study
#6
Maria T Acosta, James Swanson, Annamarie Stehli, Brooke S G Molina, Ariel F Martinez, Mauricio Arcos-Burgos, Maximilian Muenke
BACKGROUND: ADHD is the most common neuropsychiatric condition affecting individuals of all ages. Long-term outcomes of affected individuals and association with severe comorbidities as SUD or conduct disorders are the main concern. Genetic associations have been extensively described. Multiple studies show that intronic variants harbored in the ADGRL3 (LPHN3) gene are associated with ADHD, especially associated with poor outcomes. METHODS: In this study, we evaluated this association in the Multimodal Treatment Study of children with ADHD (MTA), initiated as a 14-month randomized clinical trial of 579 children diagnosed with DSM-IV ADHD-Combined Type (ADHD-C), that transitioned to a 16-year prospective observational follow-up, and 289 classmates added at the 2-year assessment to serve as a local normative comparison group (LNCG)...
September 2016: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/27612457/characterization-treatment-patterns-and-patient-related-outcomes-of-patients-with-fragile-x-syndrome-in-germany-final-results-of-the-observational-explain-fxs-study
#7
Frank Haessler, Franziska Gaese, Michael Huss, Christoph Kretschmar, Marc Brinkman, Helmut Peters, Samuel Elstner, Michael Colla, David Pittrow
BACKGROUND: As data on the phenotype, characteristics and management of patients with Fragile X Syndrome (FXS) are limited, we aimed to collect such data in Germany in experienced centres involved in the treatment of such patients. METHODS: EXPLAIN-FXS is a prospective observational (non-interventional) study (registry) performed between April 2013 and January 2016 at 18 sites in Germany. Requirements for patient participation included confirmed diagnosis of FXS by genetic testing (>200 CGG repeats) and written informed consent...
2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27500191/processed-data-for-chms-2007-2009-bisphenol-a-phthalates-and-lead-and-learning-and-behavioral-problems-in-canadian-children-6-19-years-of-age
#8
Tye E Arbuckle, Karelyn Davis, Khrista Boylan, Mandy Fisher, Jingshan Fu
This article presents processed data from an analysis of cross-sectional data from Cycle 1 of the Canadian Health Measures Survey (CHMS) to examine the potential association between urinary concentrations of BPA and phthalate metabolites and child learning and behavioral problems, considering important covariates such as gender, blood lead and environmental tobacco smoke (ETS). These processed data are related to the research on a subset of the children (Arbuckle et al., 2016) [1]. The Strengths and Difficulties Questionnaire (SDQ) outcomes of interest were emotional symptoms, hyperactivity/inattention, and a total difficulties SDQ score, with borderline and abnormal scores grouped together and compared with children with normal scores...
September 2016: Data in Brief
https://www.readbyqxmd.com/read/27472007/heterogeneity-in-adhd-neurocognitive-predictors-of-peer-family-and-academic-functioning
#9
Michael J Kofler, Dustin E Sarver, Jamie A Spiegel, Taylor N Day, Sherelle L Harmon, Erica L Wells
Childhood attention-deficit/hyperactivity disorder (ADHD) is associated with impairments in peer, family, and academic functioning. Although impairment is required for diagnosis, children with ADHD vary significantly in the areas in which they demonstrate clinically significant impairment. However, relatively little is known about the mechanisms and processes underlying these individual differences. The current study examined neurocognitive predictors of heterogeneity in peer, family, and academic functioning in a well-defined sample of 44 children with ADHD aged 8-13 years (M = 10...
July 29, 2016: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/27471442/neural-biomarkers-for-dyslexia-adhd-and-add-in-the-auditory-cortex-of-children
#10
Bettina Serrallach, Christine Groß, Valdis Bernhofs, Dorte Engelmann, Jan Benner, Nadine Gündert, Maria Blatow, Martina Wengenroth, Angelika Seitz, Monika Brunner, Stefan Seither, Richard Parncutt, Peter Schneider, Annemarie Seither-Preisler
Dyslexia, attention deficit hyperactivity disorder (ADHD), and attention deficit disorder (ADD) show distinct clinical profiles that may include auditory and language-related impairments. Currently, an objective brain-based diagnosis of these developmental disorders is still unavailable. We investigated the neuro-auditory systems of dyslexic, ADHD, ADD, and age-matched control children (N = 147) using neuroimaging, magnetencephalography and psychoacoustics. All disorder subgroups exhibited an oversized left planum temporale and an abnormal interhemispheric asynchrony (10-40 ms) of the primary auditory evoked P1-response...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27453080/cognitive-effects-of-stimulant-guanfacine-and-combined%C3%A2-treatment-in-child-and-adolescent-attention-deficit-hyperactivity-disorder
#11
Robert M Bilder, Sandra K Loo, James J McGough, Fiona Whelan, Gerhard Hellemann, Catherine Sugar, Melissa Del'Homme, Alexandra Sturm, Jennifer Cowen, Grant Hanada, James T McCracken
OBJECTIVE: Psychostimulants are partially effective in reducing cognitive dysfunction associated with attention-deficit/hyperactivity disorder (ADHD). Cognitive effects of guanfacine, an alternative treatment, are poorly understood. Given its distinct action on α2A receptors, guanfacine may have different or complementary effects relative to stimulants. This study tested stimulant and guanfacine monotherapies relative to combined treatment on cognitive functions important in ADHD. METHOD: Children with ADHD (n = 182; aged 7-14 years) completed an 8-week, double blind, randomized, controlled trial with 3 arms: d-methylphenidate (DMPH), guanfacine (GUAN), or combination treatment with DMPH and GUAN (COMB)...
August 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27373215/evaluating-use-of-higher-dose-oxybutynin-in-combination-with-desmopressin-for-refractory-nocturnal-enuresis
#12
Aaron Berkenwald, Jacqueline Pires, Pamela Ellsworth
INTRODUCTION: Nocturnal enuresis is a common pediatric condition with limited treatment options. In older children, pharmacologic therapy is often the preferred treatment. Pharmacologic therapies including desmopressin (DDAVP) or imipramine are effective in 40-50% of children. However, imipramine has serious safety concerns. Desmopressin in combination with a fixed dose anticholinergic has been shown to be useful in individuals who fail desmopressin monotherapy, but still fails to achieve success rates greater than 60%...
August 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27267090/suboptimal-decision-making-by-children-with-adhd-in-the-face-of-risk-poor-risk-adjustment-and-delay-aversion-rather-than-general-proneness-to-taking-risks
#13
Lin Sørensen, Edmund Sonuga-Barke, Heike Eichele, Heidi van Wageningen, Daniel Wollschlaeger, Kerstin Jessica Plessen
OBJECTIVE: Suboptimal decision making in the face of risk (DMR) in children with attention-deficit hyperactivity disorder (ADHD) may be mediated by deficits in a number of different neuropsychological processes. We investigated DMR in children with ADHD using the Cambridge Gambling Task (CGT) to distinguish difficulties in adjusting to changing probabilities of choice outcomes (so-called risk adjustment) from general risk proneness, and to distinguish these 2 processes from delay aversion (the tendency to choose the least delayed option) and impairments in the ability to reflect on choice options...
June 6, 2016: Neuropsychology
https://www.readbyqxmd.com/read/27255087/clinical-management-of-adhd-in-a-family-medicine-residency-program-comparison-with-aap-guidelines
#14
Jessica W Skelley, P Chase Carpenter, M Shawn Morehead, Patrick L Murphy
OBJECTIVES: Attention-deficit/hyperactivity disorder (ADHD) is the most common neurobehavioral disorder. Research has shown that even with the growing incidence of children diagnosed as having ADHD, physicians may find providing optimal care to these patients challenging. Our objective was to contrast existing clinical management of ADHD in a family medicine setting with published American Academy of Pediatrics guidelines and review the literature pertinent to differences. METHODS: A report was generated for all visits with "ADHD" or "ADD" (attention-deficit disorder) as a current or past medical problem that had been addressed at the family medicine clinic from July 2012 to June 2014...
June 2016: Southern Medical Journal
https://www.readbyqxmd.com/read/27242472/computer-enabled-neuroplasticity-treatment-a-clinical-trial-of-a-novel-design-for-neurofeedback-therapy-in-adult-adhd
#15
Benjamin Cowley, Édua Holmström, Kristiina Juurmaa, Levas Kovarskis, Christina M Krause
BACKGROUND: We report a randomized controlled clinical trial of neurofeedback therapy intervention for ADHD/ADD in adults. We focus on internal mechanics of neurofeedback learning, to elucidate the primary role of cortical self-regulation in neurofeedback. We report initial results; more extensive analysis will follow. METHODS: Trial has two phases: intervention and follow-up. The intervention consisted of neurofeedback treatment, including intake and outtake measurements, using a waiting-list control group...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27232650/methylphenidate-in-pregnancy-a-multicenter-prospective-comparative-observational-study
#16
Orna Diav-Citrin, Svetlana Shechtman, Judy Arnon, Rebecka Wajnberg, Cornelia Borisch, Evelin Beck, Jonathan Luke Richardson, Pina Bozzo, Irena Nulman, Asher Ornoy
INTRODUCTION: Methylphenidate is a central nervous system stimulant medicinally used in the treatment of attention-deficit disorder with or without hyperactivity (ADD/ADHD). Data on its use in human pregnancy are limited. The primary objective of the study was to evaluate the risk of major congenital anomalies after pregnancy exposure to methylphenidate for medical indications. METHODS: In a prospective, comparative, multicenter observational study performed in 4 participating Teratology Information Services (in Jerusalem, Berlin, Newcastle upon Tyne, and Toronto) between 1996 and 2013, methylphenidate-exposed pregnancies were compared with pregnancies counseled for nonteratogenic exposure (NTE) after matching by maternal age, gestational age, and year at initial contact...
May 24, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27179356/probabilities-of-add-adhd-and-related-substance-use-among-canadian-adults
#17
Ross D Connolly, David Speed, Jacqueline Hesson
OBJECTIVE: The aim of this study was to estimate the prevalence and probabilities of comorbidities between self-reported ADD/ADHD and smoking, alcohol binge drinking, and substance use disorders (SUDs) from a national Canadian sample. METHOD: Data were taken from the Public Use Microdata File of the 2012 Canadian Community Health Survey-Mental Health (N = 17 311). The prevalence of (a) smoking, (b) alcohol binge drinking, and (c) SUDs was estimated among those with an ADD/ADHD diagnosis versus those without an ADD/ADHD diagnosis...
May 14, 2016: Journal of Attention Disorders
https://www.readbyqxmd.com/read/27176739/two-year-prospective-study-of-characteristics-and-outcome-of-adolescents-referred-to-an-adolescent-urgent-psychiatric-clinic
#18
Nasreen Roberts, Linda Booij, Nicholas Axas, Leanne Repetti
OBJECTIVE: (a) To describe the clinical characteristics and outcome of adolescents referred for urgent psychiatric consultation, and (b) compare suicidal with non-suicidal referrals. METHODS: This was a 2-year prospective study. Data was gathered on demographic, historical and clinical variables. Comparison of suicidal and non-suicidal patients was conducted using χ2. A hospital database was used for referral and wait times. RESULTS: Of 805 assessments, 55% were referred by emergency physicians and 28% by primary care physicians...
May 13, 2016: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/27150337/associations-of-pineal-volume-chronotype-and-symptom-severity-in-adults-with-attention-deficit-hyperactivity-disorder-and-healthy-controls
#19
Jan Malte Bumb, Daniela Mier, Ingo Noelte, Michael Schredl, Peter Kirsch, Oliver Hennig, Luisa Liebrich, Sabrina Fenske, Barbara Alm, Carina Sauer, Franz Markus Leweke, Esther Sobanski
The pineal gland, as part of the human epithalamus, is the main production site of peripheral melatonin, which promotes the modulation of sleep patterns, circadian rhythms and circadian preferences (morningness vs. eveningness). The present study analyses the pineal gland volume (PGV) and its association with circadian preferences and symptom severity in adult ADHD patients compared to healthy controls. PGV was determined manually using high-resolution 3T MRI (T1-magnetization prepared rapid gradient echo) in medication free adult ADHD patients (N=74) compared to healthy controls (N=86)...
July 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27128360/attention-deficit-hyperactivity-disorder-symptoms-add-risk-to-circadian-rhythm-sleep-problems-in-depression-and-anxiety
#20
T I Bron, D Bijlenga, J J S Kooij, S W N Vogel, D Wynchank, A T F Beekman, B W J H Penninx
BACKGROUND: Comorbid ADHD symptoms may partly account for circadian rhythm disturbances in depression and anxiety disorders. METHODS: Self-reported sleep characteristics of 2090 participants in the Netherlands Study of Depression and Anxiety were assessed using the Munich Chronotype Questionnaire. We defined 3 groups: healthy controls (HC), persons with lifetime depression and/or anxiety disorders (LDA), and those with both LDA and high ADHD symptoms (LDA+ADHD), using the Conner's Adult ADHD Rating Scale...
August 2016: Journal of Affective Disorders
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