Jiasuoer Xiaokereti, Yan-Kai Guo, Zhen-Yu Dong, Mei Ma, Yan-Mei Lu, Yao-Dong Li, Xian-Hui Zhou, Ling Zhang, Bao-Peng Tang
OBJECTIVE: Autonomic imbalance plays a crucial role in obstructive sleep apnea (OSA) associated atrial fibrillation (AF). Here, we investigated the potential neural mechanism of AF induced by OSA. METHODS: Ten dogs were divided into control group (n = 5) and OSA group (n = 5). The chronic OSA model was established by repeat apnea-ventilation cycles for 4 hours a day for 12 weeks. During the process of model establishment, arterial blood gases, atrial effective refractory period (AERP), AF inducibility, normalized low-frequency power (LFnu), normalized high-frequency power (HFnu), and LFnu/ HFnu were evaluated at baseline, 4th week, 8th week, and 12th week...
2021: PloS One