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Vaccine adverse events

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https://www.readbyqxmd.com/read/27912069/immunogenicity-and-safety-of-southern-hemisphere-quadrivalent-inactivated-influenza-vaccine-a-phase-iii-open-label-study-of-adults-in-brazil
#1
Cristiano A F Zerbini, Rodrigo Ribeiro Dos Santos, Maria Jose Nunes, Jyoti Soni, Ping Li, Varsha K Jain, Opokua Ofori-Anyinam
The World Health Organization influenza forecast now includes an influenza B strain from each of the influenza B lineages (B/Yamagata and B/Victoria) for inclusion in seasonal influenza vaccines. Traditional trivalent influenza vaccines include an influenza B strain from one lineage, but because two influenza B lineages frequently co-circulate, the effectiveness of trivalent vaccines may be reduced in seasons of influenza B vaccine-mismatch. Thus, quadrivalent vaccines may potentially reduce the burden of influenza compared with trivalent vaccines...
November 29, 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27905819/mothers-preferences-regarding-new-combination-vaccines-for-their-children-in-japan-2014
#2
Aiko Shono, Masahide Kondo
A number of new vaccines to prevent childhood diseases have been introduced globally over the last few decades. Only four combination vaccines are currently available in Japan, DTaP/sIPV, DTaP, DT, and MR, leading to complex infant vaccine scheduling. This study aims to investigate mothers' preferences with respect to combination vaccines for their children, should new combination vaccines become available that have not yet been launched in Japan or that will be developed in the future. We conducted a web-based, cross-sectional survey of 1,243 mothers who had at least one child between 2 months and 3 years of age...
December 1, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27903416/post-licensure-phase-iv-safety-study-of-a-live-attenuated-japanese-encephalitis-recombinant-vaccine-in-children-in-thailand
#3
Tawee Chotpitayasunondh, Pornpimol Pruekprasert, Thanyawee Puthanakit, Chitsanu Pancharoen, Auchara Tangsathapornpong, Peninnah Oberdorfer, Pope Kosalaraksa, Olarn Prommalikit, Suwimon Tangkittithaworn, Phirangkul Kerdpanich, Chonnamet Techasaensiri, Joanna Korejwo, Sunate Chuenkitmongkol, Guy Houillon
BACKGROUND: Japanese encephalitis is a mosquito-borne viral disease endemic in most countries in Asia. A recombinant live, attenuated Japanese encephalitis virus vaccine, JE-CV, is licensed in 14 countries, including Thailand, for the prevention of Japanese encephalitis in adults and children. METHODS: This was a prospective, phase IV, open-label, multicentre, safety study of JE-CV conducted from November 2013 to April 2015, to evaluate rare serious adverse events (AEs)...
November 28, 2016: Vaccine
https://www.readbyqxmd.com/read/27899225/humoral-and-cellular-response-after-varicella-vaccination-in-vzv-igg-seronegative-kidney-transplant-candidates
#4
Marcia M L Kho, Joke M Zuijderwijk, Annemiek A van der Eijk, Ronella de Kuiper, Marieken J Boer-Verschragen, Willem Weimar, Nicole M van Besouw
BACKGROUND: In immunocompromised patients, primary infection with VZV may have a disastrous clinical course. Vaccination of VZV-seronegative patients on the waiting list for renal transplantation may prevent severe disease. However, the immunologic response of end-stage renal disease patients to peptide vaccines is far from optimal. Our question was whether end-stage renal disease patients with undetectable VZV-IgG levels were able to mount an adequate humoral and cellular response to a live attenuated varicella vaccine...
November 26, 2016: Vaccine
https://www.readbyqxmd.com/read/27898235/postexposure-prophylaxis-after-possible-anthrax-exposure-adherence-and-adverse-events
#5
Leisha D Nolen, Rita M Traxler, Grishma A Kharod, Pallavi A Kache, Stefan Katharios-Lanwermeyer, Katherine A Hendricks, Sean V Shadomy, William A Bower, Dana Meaney-Delman, Henry T Walke
Anthrax postexposure prophylaxis (PEP) was recommended to 42 people after a laboratory incident that involved potential aerosolization of Bacillus anthracis spores in 2 laboratories at the Centers for Disease Control and Prevention in 2014. At least 31 (74%) individuals who initiated PEP did not complete either the recommended 60 days of antimicrobial therapy or the 3-dose vaccine regimen. Among the 29 that discontinued the antimicrobial component of PEP, most (38%) individuals discontinued PEP because of their low perceived risk of infection; 9 (31%) individuals discontinued prophylaxis due to PEP-related minor adverse events, and 10% cited both low risk and adverse events as their reason for discontinuation...
November 29, 2016: Health Security
https://www.readbyqxmd.com/read/27895921/literature-review-of-vaccine-related-adverse-events-reported-from-hpv-vaccination-in-randomized-controlled-trials
#6
Mohamed Macki, Ali A Dabaja
BACKGROUND: The human papilloma virus (HPV) infections were addressed with two FDA-approved HPV vaccines: quadrivalent and bivalent vaccine. The objective of this manuscript is to determine the safety of the HPV vaccine. RESULTS: A search of PubMed articles for "human papillomavirus vaccine" was used to identify all-type HPV clinical studies prior to October 2014. A refined search of clinical trials, multicenter studies, and randomized studies were screened for only randomized controlled trials comparing HPV vaccine to controls (saline placebo or aluminum derivatives)...
2016: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/27895845/a-trial-of-a-7-valent-pneumococcal-conjugate-vaccine-in-hiv-infected-adults
#7
Neil French, Stephen B Gordon, Thandie Mwalukomo, Sarah A White, Gershom Mwafulirwa, Herbert Longwe, Martin Mwaiponya, Eduard E Zijlstra, Malcolm E Molyneux, Charles F Gilks
BACKGROUND: Streptococcus pneumoniae is a leading and serious coinfection in adults with human immunodeficiency virus (HIV) infection, particularly in Africa. Prevention of this disease by vaccination with the current 23-valent polysaccharide vaccine is suboptimal. Protein conjugate vaccines offer a further option for protection, but data on their clinical efficacy in adults are needed. METHODS: In this double-blind, randomized, placebo-controlled clinical efficacy trial, we studied the efficacy of a 7-valent conjugate pneumococcal vaccine in predominantly HIV-infected Malawian adolescents and adults who had recovered from documented invasive pneumococcal disease...
September 2016: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/27895844/effect-of-human-rotavirus-vaccine-on-severe-diarrhea-in-african-infants
#8
Shabir A Madhi, Nigel A Cunliffe, Duncan Steele, Desirée Witte, Mari Kirsten, Cheryl Louw, Bagrey Ngwira, John C Victor, Paul H Gillard, Brigitte B Cheuvart, Htay H Han, Kathleen M Neuzil
BACKGROUND: Rotavirus is the most common cause of severe gastroenteritis among young children worldwide. Data are needed to assess the efficacy of the rotavirus vaccine in African children. METHODS: We conducted a randomized, placebo-controlled, multicenter trial in South Africa (3166 infants; 64.1% of the total) and Malawi (1773 infants; 35.9% of the total) to evaluate the efficacy of a live, oral rotavirus vaccine in preventing severe rotavirus gastroenteritis...
September 2016: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/27894306/first-phase-i-human-clinical-trial-of-a-killed-whole-hiv-1-vaccine-demonstration-of-its-safety-and-enhancement-of-anti-hiv-antibody-responses
#9
Eunsil Choi, Chad J Michalski, Seung Ho Choo, Gyoung Nyoun Kim, Elizabeth Banasikowska, Sangkyun Lee, Kunyu Wu, Hwa-Yong An, Anthony Mills, Stefan Schneider, U Fritz Bredeek, Daniel R Coulston, Shilei Ding, Andrés Finzi, Meijuan Tian, Katja Klein, Eric J Arts, Jamie F S Mann, Yong Gao, C Yong Kang
BACKGROUND: Vaccination with inactivated (killed) whole-virus particles has been used to prevent a wide range of viral diseases. However, for an HIV vaccine this approach has been largely negated due to inherent safety concerns, despite the ability of killed whole-virus vaccines to generate a strong, predominantly antibody-mediated immune response in vivo. HIV-1 Clade B NL4-3 was genetically modified by deleting the nef and vpu genes and substituting the coding sequence for the Env signal peptide with that of honeybee melittin signal peptide to produce a less virulent and more replication efficient virus...
November 28, 2016: Retrovirology
https://www.readbyqxmd.com/read/27893654/safety-comparison-of-four-types-of-rabies-vaccines-in-patients-with-who-category-ii-animal-exposure-an-observation-based-on-different-age-groups
#10
Jun Peng, Sha Lu, Zhenggang Zhu, Man Zhang, Quan Hu, Yuan Fang
To evaluate the safeties of 4 types of rabies vaccines for patients with WHO category II animal exposure, especially in different age groups.A total of 4000 patients with WHO category II animal exposure were randomly divided into 4 vaccine groups, and were respectively given with Vaccines A, B, C, and D. And subjects in each vaccine group were divided into 4 age groups (≤5, 5-18, 19-60, and ≥60-year-old groups). Then adverse events (including local and systemic ones) were recorded and compared. Consequently, except for Vaccine B, patients under the age of 5 in Groups A, C, and D suffered from more adverse reactions than those in other age groups...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27889711/immunogenicity-and-safety-of-a-liquid-hexavalent-vaccine-in-indian-infants
#11
Jugesh Chhatwal, Sanjay Lalwani, Emmanuel Vidor
OBJECTIVE: To evaluate the immunogenicity and safety of a fully liquid, hexavalent diphtheria tetanus acellular pertussis inactivated poliovirus hepatitis B Haemophilus influenzae type b (DTaP IPV HB PRPT) vaccine in Indian infants. DESIGN: Phase III, single-arm study. SETTING: Two tertiary care hospitals. PARTICIPANTS: 177 healthy, 6-week-old infants. INTERVENTION: All participants received HB and OPV vaccines at birth and DTaP-IPV-HB-PRP~T at 6, 10, 14 weeks of age...
November 5, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27887596/effectiveness-immunogenicity-and-safety-of-23-valent-pneumococcal-polysaccharide-vaccine-revaccinations-in-the-elderly-a-systematic-review
#12
Cornelius Remschmidt, Thomas Harder, Ole Wichmann, Christian Bogdan, Gerhard Falkenhorst
BACKGROUND: In many industrialized countries routine vaccination with the 23-valent pneumococcal polysaccharide vaccine (PPSV-23) is recommended to prevent pneumococcal disease in the elderly. However, vaccine-induced immunity wanes after a few years, and there are controversies around revaccination with PPSV-23. Here, we systematically assessed the effectiveness and safety of PPSV-23 revaccination. METHOD: We conducted a systematic literature review in MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials from inception to June 2015...
November 25, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27881130/electronic-reminders-to-facilitate-longitudinal-care-a-mixed-methods-study-in-general-practices
#13
Christine Kersting, Birgitta Weltermann
BACKGROUND: Longitudinal, patient-centered care represents a challenge for general practitioners (GPs), and in this context, reminder systems can offer targeted support. This study aimed to identify details of such reminders: (1) contents of care addressed, (2) their mode of display in the electronic health record (EHR), (3) their visual appearance, (4) personnel responsibilities for editing and applying reminders, and (5) use of reminders for patient recall. METHODS: This mixed-methods study comprised (1) a cross-sectional survey among 185 GP practices from a German university network, and (2) structured observations of reminder utilization in six practices based on a clinical vignette describing a multimorbid senior with 26 care needs...
November 24, 2016: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/27879555/safety-and-immunogenicity-of-dtap5-ipv-compared-with-dtap5-plus-ipv-as-the-fifth-dose-in-children-4-to-6-years-of-age
#14
Michael J Smith, Emilia Jordanov, Xiaohua Sheng, Peter H Tsang
BACKGROUND: Immunogenicity and safety of stand-alone diphtheria, tetanus toxoid, 5-component acellular pertussis vaccine adsorbed, inactivated poliovirus (IPV) combination vaccine (DTaP5-IPV) was compared with separate DTaP5 plus IPV vaccines as fifth dose in children 4-6 years of age. METHODS: In this phase III, controlled, multicenter, randomized, open-label study participants were randomized to DTaP5-IPV plus measles/mumps/rubella (MMR) and varicella virus (VZV) vaccines (Group 1; N=324), DTaP5+IPV with MMR and VZV (Group 2; N=327), DTaP5-IPV with/without MMR/VZV (Group 3; N=2419), or DTaP5+IPV with/without MMR/VZV (Group 4; N=302)...
November 22, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27876690/-mommy-blogs-and-the-vaccination-exemption-narrative-results-from-a-machine-learning-approach-for-story-aggregation-on-parenting-social-media-sites
#15
Timothy R Tangherlini, Vwani Roychowdhury, Beth Glenn, Catherine M Crespi, Roja Bandari, Akshay Wadia, Misagh Falahi, Ehsan Ebrahimzadeh, Roshan Bastani
BACKGROUND: Social media offer an unprecedented opportunity to explore how people talk about health care at a very large scale. Numerous studies have shown the importance of websites with user forums for people seeking information related to health. Parents turn to some of these sites, colloquially referred to as "mommy blogs," to share concerns about children's health care, including vaccination. Although substantial work has considered the role of social media, particularly Twitter, in discussions of vaccination and other health care-related issues, there has been little work on describing the underlying structure of these discussions and the role of persuasive storytelling, particularly on sites with no limits on post length...
November 22, 2016: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/27869969/influenza-vaccination-among-elderly-in-pelotas-rs-brazil-2014-a-population-based-study
#16
Rosália Garcia Neves, Suele Manjourany Silva Duro, Elaine Tomasi
OBJECTIVE: to describe the prevalence of individuals vaccinated against influenza and associated factors with vaccination among elderly; identify reasons for noncompliance and adverse events. METHODS: this was a cross-sectional study, conducted in the urban area of Pelotas-RS, Brazil, in 2014. RESULTS: out of 1,451 elderly, 71% got vaccinated; the highest prevalences were observed in the elderly with better economic status (PR=1.2 - 95%CI 1...
October 2016: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/27868103/integrative-representations-and-analyses-of-vaccine-induced-intended-protective-immunity-and-unintended-adverse-events-using-ontology-based-and-theory-guided-approaches
#17
Yongqun He, Edison Ong, Jiangan Xie
No abstract text is available yet for this article.
June 2016: Global Vaccines and Immunology
https://www.readbyqxmd.com/read/27866772/h1-ic31-vaccination-is-safe-and-induces-long-lived-tnf-%C3%AE-il-2-cd4-t-cell-responses-in-m-tuberculosis-infected-and-uninfected-adolescents-a-randomized-trial
#18
Helen Mearns, Hennie D Geldenhuys, Benjamin M Kagina, Munyaradzi Musvosvi, Francesca Little, Frances Ratangee, Hassan Mahomed, Willem A Hanekom, Søren T Hoff, Morten Ruhwald, Ingrid Kromann, Peter Bang, Mark Hatherill, Peter Andersen, Thomas J Scriba
BACKGROUND: Control of the tuberculosis epidemic requires a novel vaccine that is effective in preventing tuberculosis in adolescents, a key target population for vaccination against TB. METHODS: Healthy adolescents, stratified by M. tuberculosis-infection status, were enrolled into this observer-blinded phase II clinical trial of the protein-subunit vaccine candidate, H1:IC31, comprising a fusion protein (H1) of Ag85B and ESAT-6, formulated with the IC31 adjuvant...
November 17, 2016: Vaccine
https://www.readbyqxmd.com/read/27866765/safety-tolerability-and-immunogenicity-of-a-single-dose-4-antigen-or-3-antigen-staphylococcus-aureus-vaccine-in-healthy-older-adults-results-of-a-randomised-trial
#19
C Buddy Creech, Robert W Frenck, Eric A Sheldon, David J Seiden, Martin K Kankam, Edward T Zito, Douglas Girgenti, Joseph M Severs, Frederick W Immermann, Lisa K McNeil, David Cooper, Kathrin U Jansen, William Gruber, Joseph Eiden, Annaliesa S Anderson, James Baber
BACKGROUND: The decline in immune function with age is a challenge to vaccine development. Following an initial study in adults aged 18-64years, this study evaluated the safety and immunogenicity of Staphylococcus aureus (S. aureus) 4-antigen (SA4Ag) and 3-antigen (SA3Ag) vaccine in older adults. SA3Ag included capsular polysaccharide serotypes 5 and 8 (CP5 and CP8) conjugated to the nontoxic mutant form of diphtheria toxin (CRM197) and a recombinant version of clumping factor A (ClfA)...
November 17, 2016: Vaccine
https://www.readbyqxmd.com/read/27861677/analysis-of-adverse-events-following-immunization-in-minas-gerais-brazil-2011-a-cross-sectional-study
#20
Suelem Santos Silva, Valéria Conceição de Oliveira, Helen Cristiny Teodoro Couto Ribeiro, Tamara Gabriela Silva Alves, Ricardo Bezerra Cavalcante, Eliete Albano de Azevedo Guimarães
OBJECTIVE: to analyze the main adverse events occurring following immunization in Minas Gerais State, Brazil, in 2011. METHODS: this is a cross-sectional study using secondary data from the Brazilian Information System on Adverse Events Following Immunization. RESULTS: 1,449 adverse events were found; more than half occurred in children under one year of age (56.1%; OR=1.39; 95%CI: 1.08;1.78); the highest rates per 100,000 doses administered were found in the Southern Triangle (36...
January 2016: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
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