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https://www.readbyqxmd.com/read/29451000/novel-automated-immune-turbidimetric-assay-for-routine-urinary-cystatin-c-determinations
#1
Balázs Szirmay, Péter Kustán, Zoltán Horváth-Szalai, Andrea Ludány, Ágnes Lakatos, Diána Mühl, István Wittmann, Attila Miseta, Gábor L Kovács, Tamás Kőszegi
AIM: There is no commercially available urinary cystatin-C (u-CYSC) test in the market. Therefore, we optimized and validated an automated immune turbidimetric test for u-CYSC measurements and investigated u-CYSC concentrations in acute and chronic diseases which might lead to renal tubular disorders. MATERIALS & METHODS: A particle-enhanced immune turbidimetric assay was adapted and validated on a Cobas 8000/c502 analyzer. Urine samples of different patient groups were also analyzed...
February 16, 2018: Bioanalysis
https://www.readbyqxmd.com/read/29448179/elevated-neutrophil-to-lymphocyte-ratio-in-non-affective-psychotic-adolescent-inpatients-evidence-for-early-association-between-inflammation-and-psychosis
#2
Yael Bustan, Adi Drapisz, David H Ben Dor, Matan Avrahami, Maya Schwartz-Lifshitz, Abraham Weizman, Ran Barzilay
Accumulating data suggest an association between inflammation and schizophrenia and related psychosis. While several studies have established this immune-psychosis association in adult schizophrenia patients, there is very limited data associating inflammation with acute psychosis in children and adolescents. The ratio between neutrophils and lymphocyte, computed from routine blood counts, has been shown to correlate with traditional markers of inflammation, and is therefore considered a proxy-marker for inflammation...
February 12, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29444257/comparison-of-strategies-and-incidence-thresholds-for-vi-conjugate-vaccines-against-typhoid-fever-a-cost-effectiveness-modeling-study
#3
Nathan C Lo, Ribhav Gupta, Jeffrey D Stanaway, Denise O Garrett, Isaac I Bogoch, Stephen P Luby, Jason R Andrews
Background: Typhoid fever remains a major public health problem globally. While new Vi conjugate vaccines hold promise for averting disease, the optimal programmatic delivery remains unclear. We aimed to identify the strategies and associated epidemiologic conditions under which Vi conjugate vaccines would be cost-effective. Methods: We developed a dynamic, age-structured transmission and cost-effectiveness model that simulated multiple vaccination strategies with a typhoid Vi conjugate vaccine from a societal perspective...
February 12, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29443045/routine-screening-method-for-microparticles-in-platelet-transfusions
#4
Daniel Millar, Larry Murphy, Audrey Labrie, Elisabeth Maurer-Spurej
Platelet inventory management based on screening microparticle content in platelet concentrates is a new quality improvement initiative for hospital blood banks. Cells fragment off microparticles (MP) when they are stressed. Blood and blood components may contain cellular fragments from a variety of cells, most notably from activated platelets. When performing their roles as innate immune cells and major players in coagulation and hemostasis, platelets change shape and generate microparticles. With dynamic light scattering (DLS)-based microparticle detection, it is possible to differentiate activated (high microparticle) from non-activated (low microparticle) platelets in transfusions, and optimize the use of this scarce blood product...
January 31, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29441651/invasive-pneumococcal-infections-in-pediatric-liver-small-bowel-pancreas-transplant-recipients
#5
Hanh D Vo, Diana F Florescu, Cindy R Brown, Heather E Chambers, David F Mercer, Luciano M Vargas, Wendy J Grant, Alan N Langnas, Ruben E Quiros-Tejeira
Children undergoing LSBPTx are at increased risk of IPI due to splenectomy. We aimed to describe the clinical features and outcomes of IPI in pediatric LSBPTx recipients. Between 2008 and 2016, 122 LSBPTx children at our center were retrospectively reviewed. Nine patients had 12 episodes of IPI; the median age at first infection was 3.5 years (range: 1.5-7.1 years). The median time from transplant to first infection was 3 years (range: 0.8-5.8 years). Clinical presentation included as follows: pneumonia (n = 1), bacteremia/sepsis (n = 7), pneumonia with sepsis (n = 1), meningitis with sepsis (n = 2), pneumonia and meningitis with sepsis (n = 1)...
February 13, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29439885/early-tissue-effects-of-stereotactic-body-radiation-therapy-for-spinal-metastases
#6
Jasper G Steverink, Stefan M Willems, Marielle E P Philippens, Nicolien Kasperts, Wietse S C Eppinga, Anne L Versteeg, Joanne M van der Velden, Salman Faruqi, Arjun Sahgal, Jorrit-Jan Verlaan
PURPOSE: Stereotactic body radiation therapy (SBRT) is a highly effective and potentially ablative treatment for complex spinal metastases. Recent data have suggested radiobiologic effects of SBRT that expand beyond the traditional concept of DNA damage. Antitumor immunity, vascular damage leading to tumor necrosis, and increased rates of tumor apoptosis have been implied; however, in-human evidence remains scarce. The present study reports unique pathologic confirmation of SBRT-induced biological effects within spinal metastases treated with preoperative SBRT...
January 6, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29439866/mass-media-effect-on-vaccines-uptake-during-silent-polio-outbreak
#7
Iftach Sagy, Victor Novack, Michael Gdalevich, Dan Greenberg
BACKGROUND: During 2013, isolation of a wild type 1 poliovirus from routine sewage sample in Israel, led to a national OPV campaign. During this period, there was a constant cover of the outbreak by the mass media. AIMS: To investigate the association of media exposure and OPV and non-OPV vaccines uptake during the 2013 silent polio outbreak in Israel. METHODS: We received data on daily immunization rates during the outbreak period from the Ministry of Health (MoH)...
February 10, 2018: Vaccine
https://www.readbyqxmd.com/read/29433129/-routine-vaccination-strategies-reactive-vaccination-and-pandemic-preparedness-and-response
#8
Giovanni Rezza
Vaccines represent the most important public health tools. In order to ensure the success of an effective and safe vaccine, it is important to implement adequate immunization strategies. Routine strategies, based on children immunization schedules, represent the most commonly utilized approach. Reactive immunization strategies may also be used and be effective especially in response to an outbreak; these strategies include both mass vaccination and ring vaccination, which relies on the identification and immunization of case contacts...
September 2017: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/29432666/impact-of-rotavirus-vaccination-on-rotavirus-hospitalization-rates-among-a-resource-limited-rural-population-in-mbita-western-kenya
#9
Ernest Apondi Wandera, Shah Mohammad, Martin Bundi, James Nyangao, Amina Galata, Cyrus Kathiiko, Erick Odoyo, Sora Guyo, Gabriel Miring'u, Satoshi Komoto, Yoshio Ichinose
OBJECTIVES: A two-dose oral monovalent rotavirus vaccine (RV1) was introduced into the Kenyan National Immunization Program in July 2014. We assessed trends in hospitalization for rotavirus-specific acute gastroenteritis (AGE) and strain distribution among children <5 years in a rural, resource-limited setting in Kenya before and after the nationwide implementation of the vaccine. METHODS: Data on rotavirus AGE and strain distribution were derived from a five-year hospital-based surveillance...
February 12, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29432552/routine-immunization-in-pakistan-comparison-of-multiple-data-sources-and-identification-of-factors-associated-with-vaccination
#10
Hafsa Imran, Dania Raja, Nicholas C Grassly, M Zubair Wadood, Rana M Safdar, Kathleen M O'Reilly
Background: Within Pakistan, estimates of vaccination coverage with the pentavalent vaccine, oral polio vaccine (OPV) and measles vaccine (MV) in 2011 were reported to be 74%, 75% and 53%, respectively. These national estimates may mask regional variation. The reasons for this variation have not been explored. Methods: Data from the Multiple Indicator Cluster Surveys (MICS) for Balochistan and Punjab (2010-2011) are analysed to examine factors associated with receiving three or more doses of the pentavalent vaccine and one or more MVs using regression modelling...
February 8, 2018: International Health
https://www.readbyqxmd.com/read/29429807/post-hoc-analysis-of-the-efficacy-of-the-13-valent-pneumococcal-conjugate-vaccine-against-vaccine-type-community-acquired-pneumonia-in-at-risk-older-adults
#11
José A Suaya, Qin Jiang, Daniel A Scott, William C Gruber, Chris Webber, Beate Schmoele-Thoma, Cassandra K Hall-Murray, Luis Jodar, Raul E Isturiz
BACKGROUND: Individuals with certain chronic medical conditions are at higher risk of developing pneumonia and pneumococcal disease than those without. Using data from the Community-Acquired Pneumonia Immunization Trial in Adults (CAPiTA), this post hoc analysis assessed the efficacy of the 13-valent pneumococcal conjugate vaccine (PCV13) in adults aged ≥65 years with at-risk conditions. METHODS: The Community-Acquired Pneumonia Immunization Trial in Adults (CAPiTA) was a double-blind, parallel-group, randomized, placebo-controlled study in the Netherlands in which adults aged ≥65 years received either PCV13 or placebo...
February 8, 2018: Vaccine
https://www.readbyqxmd.com/read/29429027/immunization-coverage-in-children-with-inflammatory-bowel-disease
#12
K Kowalska-Duplaga, M Baranowska-Nowak, M Nescioruk, M Banasiuk, K Karolewska-Bochenek, I Łazowska-Przeorek, A Radzikowski, Aleksandra Banaszkiewicz
Patients suffering from inflammatory bowel diseases (IBD) are at increased risk of infections, mainly due to immunosuppressive treatment. Moreover, infections may cause flares of IBD. Vaccination is the most effective way of preventing many infections. The aim of this study was to evaluate the vaccination status of Polish children with IBD. Individual immunization cards of children with IBD and healthy controls were reviewed. Demographic data such as age, sex, and IBD history, including therapy type, were collected...
February 11, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29425201/a-novel-antibody-surrogate-biomarker-to-monitor-parasite-persistence-in-trypanosoma-cruzi-infected-patients
#13
Maan Zrein, Elodie Granjon, Lucie Gueyffier, Julie Caillaudeau, Peter Liehl, Hans Pottel, Clareci Silva Cardoso, Claudia Di Lorenzo Oliveira, Lea Campos de Oliveira, Tzong-Hae Lee, Ariela Mota Ferreira, Antonio Luiz P Ribeiro, Michael P Busch, Ester Cerdeira Sabino
BACKGROUND: Trypanosoma cruzi parasite, the causative agent of Chagas disease, infects about six million individuals in more than 20 countries. Monitoring parasite persistence in infected individuals is of utmost importance to develop and evaluate treatments to control the disease. Routine screening for infected human individuals is achieved by serological assays; PCR testing to monitor spontaneous or therapy-induced parasitological cure has limitations due to the low and fluctuating parasitic load in circulating blood...
February 9, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29422392/the-immune-imbalance-in-the-second-hit-of-pancreatitis-is-independent-of-il-17a
#14
John-Edwin Thomson, Martin Brand, Pascaline Fonteh
BACKGROUND: Severe acute pancreatitis (SAP) is characterised by two distinct clinical phases. Organ dysfunction and death is initially as a result of a systemic inflammatory response syndrome (SIRS). Systemic sepsis from infected pancreatic necrosis characterises the second phase, the so called 'second hit' of acute pancreatitis (AP). An immune imbalance during the second hit is postulated to contribute to the formation of the septic complications that occur in these patients. The pro-inflammatory T-helper (Th) 17 pathway has been shown to be an initiator of early SIRS in AP, however to date its role has not been established in the second hit in AP...
January 31, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29420131/t-cell-receptor-excision-circle-levels-and-safety-of-paediatric-immunization-a-population-based-self-controlled-case-series-analysis
#15
Kumanan Wilson, Daniel R Duque, Malia Sq Murphy, Steven Hawken, Anne Pham-Huy, Jeffrey Kwong, Shelley L Deeks, Beth K Potter, Natasha S Crowcroft, Dennis E Bulman, Pranesh Chakraborty, Julian Little
T-cell receptor excision circle levels are a surrogate marker of T-cell production and immune system function. We sought to determine whether non-pathological infant T-cell receptor excision circle levels were associated with adverse events following immunization. A self-controlled case series design was applied on a sample of 231,693 children who completed newborn screening for severe combined immunodeficiency in Ontario, Canada between August 2013 and December 2015. Exposures included routinely administered pediatric vaccines up to 15 months of age...
February 8, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29417364/maternal-care-providers-barriers-regarding-influenza-and-pertussis-vaccination-during-pregnancy-in-catalonia-spain
#16
Luz Maria Vilca, Cristina Martínez, Miriam Burballa, Magda Campins
Objective Maternal care providers (MCPs), obstetrician-gynaecologists and midwives are uniquely placed to increase maternal vaccination acceptance. We aimed to assess their knowledge, attitudes and practices regarding influenza and pertussis vaccination during pregnancy. Methods We conducted an online survey among MCPs working at "Attention to Sexual and Reproductive Health" (ASSIR) Units in Catalonia region. The survey included questions about current recommendations of influenza and pertussis immunization during pregnancy, reasons for not routinely recommending vaccination and several strategies to increase vaccination uptake...
February 7, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29416876/histological-scoring-of-immune-and-stromal-features-in-breast-and-axillary-lymph-nodes-is-prognostic-for-distant-metastasis-in-lymph-node-positive-breast-cancers
#17
Anita Grigoriadis, Patrycja Gazinska, Trupti Pai, Sheeba Irhsad, Yin Wu, Rosemary Millis, Kalnisha Naidoo, Julie Owen, Cheryl E Gillett, Andrew Tutt, Anthonius Cc Coolen, Sarah E Pinder
The prognostic importance of lymph node (LN) status and tumour-infiltrating lymphocytes (TILs), is well established, particularly TILs in triple negative breast cancers (TNBCs). So far, few studies have interrogated changes in involved and uninvolved LNs and evaluated if their morphological patterns add valuable information for the prediction of disease progression in breast cancer. In a cohort of 309 patients enriched for TNBCs (170/309), we histologically characterised immune and stromal features in primary tumours and associated involved and uninvolved axillary LNs on routine haematoxylin and eosin stained sections...
January 2018: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/29416539/adjuvant-effect-of-bacille-calmette-gu%C3%A3-rin-on-hepatitis-b-vaccine-immunogenicity-in-the-preterm-and-term-newborn
#18
Annette Scheid, Francesco Borriello, Carlo Pietrasanta, Helen Christou, Joann Diray-Arce, Matthew A Pettengill, Sweta Joshi, Ning Li, Ilana Bergelson, Tobias Kollmann, David J Dowling, Ofer Levy
Immunization is key to protecting term and preterm infants from a heightened risk of infection. However, preterm immunity is distinct from that of the term, limiting its ability to effectively respond to vaccines routinely given at birth, such as hepatitis B vaccine (HBV). As part of the Expanded Program on Immunization, HBV is often given together with the live-attenuated vaccine Bacille Calmette-Guérin (BCG), known to activate multiple pattern-recognition receptors. Of note, some clinical studies suggest BCG can enhance efficacy of other vaccines in term newborns...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29413097/a-cross-sectional-study-of-the-relationship-between-infant-thimerosal-containing-hepatitis-b-vaccine-exposure-and-attention-deficit-hyperactivity-disorder
#19
David A Geier, Janet K Kern, Kristin G Homme, Mark R Geier
Attention-deficit/hyperactivity disorder (ADHD) is characterized by a marked pattern of inattention and/or hyperactivity-impulsivity that is inconsistent with developmental level and interferes with normal functioning in at least two settings. This study evaluated the hypothesis that infant Thimerosal-containing hepatitis B vaccine (T-HepB) exposure would increase the risk of an ADHD diagnosis. This cross-sectional study examined 4393 persons between 13 and 19 years of age from the combined 1999-2004 National Health and Nutritional Examination Survey (NHANES) by analyzing demographic, immunization, socioeconomic, and health-related variables using the SAS system...
March 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29413057/tumor-biomarker-testing-in-non-small-cell-lung-cancer-a-decade-of-change
#20
Paul A VanderLaan, Deepa Rangachari, Adnan Majid, Mihir S Parikh, Sidharta P Gangadharan, Michael S Kent, Danielle C McDonald, Mark S Huberman, Susumu S Kobayashi, Daniel B Costa
INTRODUCTION: Although a growing list of essential genomic/immune-based biomarkers are linked to approved non-small-cell lung cancer (NSCLC) therapies worldwide, few reports have detailed the evolution of NSCLC predictive biomarker assessment in routine clinical practice. METHODS: We retrospectively reviewed the first one thousand plus NSCLC patient specimens from our institution analyzed for predictive biomarkers from 2004 to 2017 and evaluated patterns of testing as well as correlation with clinical-pathologic characteristics...
February 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
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