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https://www.readbyqxmd.com/read/29241751/hidradenitis-suppurativa-and-the-metabolic-syndrome
#1
Tulin Ergun
The association of the metabolic syndrome (MetS) and its components with immune-mediated chronic inflammatory disorders has attracted much interest within the last two decades. In addition to the well-established association of psoriasis with MetS, recent data point to an association between MetS and hidradenitis suppurativa, as well. The association of hidradenitis suppurativa with MetS and its components, such as diabetes, obesity, and dyslipidemia, has been consistently identified in controlled studies. This relationship is not only limited to older individuals but also applicable to younger patients and those with mild disease...
January 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29240729/introduction-of-inactivated-poliovirus-vaccine-and-impact-on-vaccine-associated-paralytic-poliomyelitis-beijing-china-2014-2016
#2
Dan Zhao, Rui Ma, Tao Zhou, Fan Yang, Jin Wu, Hao Sun, Fang Liu, Li Lu, Xiaomei Li, Shuyan Zuo, Wei Yao, Jian Yin
When included in a sequential polio vaccination schedule, inactivated polio vaccine (IPV) reduces the risk for vaccine-associated paralytic poliomyelitis (VAPP), a rare adverse event associated with receipt of oral poliovirus vaccine (OPV). During January 2014, the World Health Organization (WHO) recommended introduction of at least 1 IPV dose into routine immunization schedules in OPV-using countries (1). The Polio Eradication and Endgame Strategic Plan 2013-2018 recommended completion of IPV introduction in 2015 and globally synchronized withdrawal of OPV type 2 in 2016 (2)...
December 15, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29239188/-evaluation-of-inflammatory-cells-tumor-infiltrating-lymphocytes-in-solid-tumors
#3
P Dundr, K Němejcová, M Bártů, R Matěj, Z Rohan, I Tichá
BACKGROUND: The tumor microenvironment plays an important role in tumorigenesis and the tumor-host relationship. An important part of the tumor microenvironment is inflammatory infiltration. Its evaluation in solid tumors has prognostic meaning and appears also to be predictive of outcome, which is particularly important for predicting responses to immune checkpoint inhibitors. However, the methodology used to assess inflammatory infiltration is problematic, because it has been standardized only for certain types of tumors...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29237479/birth-delivery-method-affects-expression-of-immune-genes-in-lung-and-jejunum-tissue-of-neonatal-beef-calves
#4
Carla Surlis, Keelan McNamara, Eoin O'Hara, Sinead Waters, Marijke Beltman, Joseph Cassidy, David Kenny
BACKGROUND: Caesarean section is a routine veterinary obstetrical procedure employed to alleviate dystocia in cattle. However, CS, particularly before the onset of labour, is known to negatively affect neonatal respiration and metabolic adaptation in humans, though there is little published information for cattle. The aim of this study was to investigate the effect of elective caesarean section (ECS) or normal trans-vaginal (TV) delivery, on lung and jejunal gene expression profiles of neonatal calves...
December 14, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29236585/impact-of-meningococcal-c-conjugate-vaccination-programs-with-and-without-catch-up-campaigns-in-adolescents-lessons-learned-from-bahia-brazil
#5
Lara Evellyn do, Viviane Ferreira, Caroline Feitosa, Amelia Nunes, Leila Campos, Marco Aurélio P Sáfadi
The significant increase in the incidence rates and ongoing outbreaks of serogroup C meningococcal (MenC) disease, associated with the sequence type-103 complex, motivated the incorporation of the meningococcal C conjugate (MCC) vaccine in the routine immunization program in the State of Bahia, Brazil in early 2010, targeting children younger than 5 years of age. In its capital, Salvador, the program also included a catch-up campaign for individuals 10-24 years of age. We performed an observational, ecological study, analyzing data collected from 2007 to 2015, to compare the impact of these two immunization strategies on meningococcal disease incidence and mortality rates...
December 13, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29235195/human-pluripotent-stem-cells-to-produce-cell-based-cancer-immunotherapy
#6
REVIEW
Huang Zhu, Yi-Shin Lai, Ye Li, Robert Blum, Dan Kaufman
Human pluripotent stem cells (PSCs) provide a promising resource to produce immune cells for adoptive cellular immunotherapy to better treat and potentially cure otherwise lethal cancers. Cytotoxic T cells and natural killer (NK) cells can now be routinely produced from human PSCs. These PSC-derived lymphocytes have phenotype and function similar to primary lymphocytes isolated from peripheral blood. PSC-derived T and NK cells have advantages compared to primary immune cells, as they can be precisely engineered to introduce improved anti-tumor activity and produced in essentially unlimited numbers...
December 13, 2017: Stem Cells
https://www.readbyqxmd.com/read/29235061/differential-expression-of-immune-factor-between-patients-with-chronic-prostatitis-chronic-pelvic-pain-syndrome-and-the-healthy-volunteers
#7
Chen Ye, Guang'an Xiao, Jian Xu, Shengfei Qin, Yuhua Luo, Guanghua Chen, H Henry Lai, Tie Zhou
PURPOSE: Immune mechanisms have been hypothesized to contribute to the development of CP/CPPS. In this study, we investigated the differential expression of immune factors between patients with CP/CPPS and healthy volunteers. METHODS: This study was registered in Australian New Zealand Clinical Trials Registry. Healthy volunteers and patients with CP/CPPS were enrolled in this study. The inclusion criteria for patients were below: (1) aged 18-45 years old; (2) prostatitis-related syndrome longer than 3 months; (3) normal routine urine culture and negative bacterial culture in prostatic fluid...
December 12, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29234135/comparative-epidemiology-of-poliovirus-transmission
#8
Navideh Noori, John M Drake, Pejman Rohani
Understanding the determinants of polio transmission and its large-scale epidemiology remains a public health priority. Despite a 99% reduction in annual wild poliovirus (WPV) cases since 1988, tackling the last 1% has proven difficult. We identified key covariates of geographical variation in polio transmission patterns by relating country-specific annual disease incidence to demographic, socio-economic and environmental factors. We assessed the relative contributions of these variables to the performance of computer-generated models for predicting polio transmission...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233955/the-effect-of-various-stabilizers-on-preserving-immunogenicity-of-lyophilized-mumps-vaccines
#9
Razieh Kamali Jamil, Mohammad Shayestehour, Zohreh-Azita Sadigh, Mohammad Taqavian, Mohammad-Kazem Shahkarami, Fatemeh Esna-Ashari, Reza Shahbazi, Ashraf Mohammadi, Abolhassan Foroughi, Bizhan Romani
BACKGROUND: Chemical stabilizers are added to live attenuated vaccines for enhancing the virus stability. The aim of this study was to evaluate the effect of various stabilizers on preserving immunogenicity of lyophilized mumps vaccines. STUDY DESIGN: An experimental study. METHODS: Three mumps vaccines with different formulations were inoculated to three groups of Guinea pigs. Sterile water was injected to eight Guinea pigs as a control group...
September 12, 2017: Journal of Research in Health Sciences
https://www.readbyqxmd.com/read/29229844/cytokine-signaling-through-drosophila-mthl10-ties-lifespan-to-environmental-stress
#10
Eui Jae Sung, Masasuke Ryuda, Hitoshi Matsumoto, Outa Uryu, Masanori Ochiai, Molly E Cook, Na Young Yi, Huanchen Wang, James W Putney, Gary S Bird, Stephen B Shears, Yoichi Hayakawa
A systems-level understanding of cytokine-mediated, intertissue signaling is one of the keys to developing fundamental insight into the links between aging and inflammation. Here, we employed Drosophila, a routine model for analysis of cytokine signaling pathways in higher animals, to identify a receptor for the growth-blocking peptide (GBP) cytokine. Having previously established that the phospholipase C/Ca2+ signaling pathway mediates innate immune responses to GBP, we conducted a dsRNA library screen for genes that modulate Ca2+ mobilization in Drosophila S3 cells...
December 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29229160/postoperative-anti-pd-1-antibody-treatment-to-reduce-recurrence-in-a-cancer-ablation-surgical-wound
#11
Nayeon Choi, Da-Yong Shin, Hye Jin Kim, Uk Yeol Moon, Kwan-Hyuck Baek, Han-Sin Jeong
BACKGROUND: Postoperative radiation and chemotherapy are routinely applied for microscopic residual diseases; however, treatment outcomes are not optimal, and patients frequently suffer from treatment-related toxicities. To search for an effective and less-toxic adjuvant treatment for patients with high risk of recurrence, the preventive effect of anti-programmed cell death protein 1 (PD-1) treatment was evaluated in an in vivo animal model of post-surgical tumor recurrence. MATERIALS AND METHODS: An animal model of postsurgical tumor recurrence (SCCVII tumors in C3H mice) was established by reinoculating tumor cells (105 cells) into surgical wound of primary tumor resection...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29225661/maternal-nutritional-status-during-pregnancy-and-infant-immune-response-to-routine-childhood-vaccinations
#12
REVIEW
Olayinka Obanewa, Marie-Louise Newell
To systematically review the association between maternal nutritional status in pregnancy and infant immune response to childhood vaccines. We reviewed literature on maternal nutrition during pregnancy, fetal immune system and vaccines and possible relationships. Thereafter, we undertook a systematic review of the literature of maternal nutritional status and infant vaccine response, extracted relevant information, assessed quality of the nine papers identified and present findings in a narrative format. From limited evidence of average quality, intrauterine nutrition deficiency could lead to functional deficit in the infant's immune function; child vaccine response may thus be negatively affected by maternal malnutrition...
September 2017: Future Virology
https://www.readbyqxmd.com/read/29225627/isolation-and-molecular-characterization-of-amniotic-fluid-derived-mesenchymal-stem-cells-obtained-from-caesarean-sections
#13
Lucas-Sebastian Spitzhorn, Md Shaifur Rahman, Laura Schwindt, Huyen-Tran Ho, Wasco Wruck, Martina Bohndorf, Silke Wehrmeyer, Audrey Ncube, Ines Beyer, Carsten Hagenbeck, Percy Balan, Tanja Fehm, James Adjaye
Human amniotic fluid cells are immune-privileged with low immunogenicity and anti-inflammatory properties. They are able to self-renew, are highly proliferative, and have a broad differentiation potential, making them amenable for cell-based therapies. Amniotic fluid (AF) is routinely obtained via amniocentesis and contains heterogeneous populations of foetal-derived progenitor cells including mesenchymal stem cells (MSCs). In this study, we isolated human MSCs from AF (AF-MSCs) obtained during Caesarean sections (C-sections) and characterized them...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29224773/parental-knowledge-and-attitudes-to-childhood-hearing-loss-and-hearing-services-in-the-solomon-islands
#14
Annette Kaspar, Obiga Newton, Joseph Kei, Carlie Driscoll, De Wet Swanepoel, Helen Goulios
OBJECTIVE: An understanding of parental knowledge and attitudes towards childhood hearing loss is essential to the successful implementation of audiology services. The present study aimed to investigate parental knowledge and attitudes among parents in the Solomon Islands. METHODS AND MATERIALS: A total of 100 mothers and 50 fathers were administered a questionnaire via semi-structured interviews. RESULTS: Highest parental awareness of aetiology of childhood hearing loss was noted for otitis media (94%), noise exposure (87...
December 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29223486/cost-effectiveness-of-rotavirus-vaccination-in-ghana-examining-impacts-from-2012-to-2031
#15
Justice Nonvignon, Deborah Atherly, Clint Pecenka, Moses Aikins, Lauren Gazley, Devin Groman, Clement T Narh, George Armah
BACKGROUND: Diarrhea causes about 10% of all deaths in children under five years globally, with rotavirus causing about 40% of all diarrhea deaths. Ghana introduced rotavirus vaccination as part of routine immunization in 2012 and it has been shown to be effective in reducing disease burden in children under five years. Ghana's transition from low to lower-middle income status in 2010 implies fewer resources from Gavi as well as other major global financing mechanisms. Ghana will soon bear the full cost of vaccines...
December 6, 2017: Vaccine
https://www.readbyqxmd.com/read/29219093/feasibility-of-implementing-a-cellphone-based-reminder-recall-strategy-to-improve-childhood-routine-immunization-in-a-low-resource-setting-a-descriptive-report
#16
Victoria Bolanle Brown, O Abimbola Oluwatosin
BACKGROUND: Reminder/recall systems are effective ways to improve immunization rates, but their feasibility in primary health care (PHC) settings in Nigeria has not been adequately evaluated. In this study we describe the acceptability and adaptability of immunization reminder/recall system in an urban setting in southwest Nigeria. METHODS: This is a descriptive report of a cluster randomized controlled trial. Four local government areas (LGAs) were randomly assigned into a cellphone reminder/recall intervention group or a usual care control group...
December 4, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29215933/a-randomized-phase-ii-trial-of-induction-chemotherapy-followed-by-cisplatin-chronotherapy-versus-constant-rate-delivery-combined-with-radiotherapy
#17
P X Zhang, F Jin, Z L Li, W L Wu, Y Y Li, J H Long, G Y Chen, X X Chen, J Y Gan, X Y Gong, Q Y He, T Bi
Chronotherapy is no longer a novel concept in cancer treatment after approximately 20 years of development. Many clinical trials have provided strong supporting evidence that chronomodulated treatment yields better results than a traditional dosage regimen. This study aimed to evaluate the adverse reactions, effect on immune functions, and therapeutic efficacy of chronomodulated infusion versus flat intermittent infusion of cisplatin (DDP) combined with intensity-modulated radiation therapy (IMRT) in patients with locoregionally advanced nasopharyngeal carcinoma (NPC)...
December 7, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29215634/expansion-of-patient-derived-circulating-tumor-cells-from-liquid-biopsies-using-a-ctc-microfluidic-culture-device
#18
Bee Luan Khoo, Gianluca Grenci, Ying Bena Lim, Soo Chin Lee, Jongyoon Han, Chwee Teck Lim
The development of personalized cancer therapy depends on a robust system to monitor the patient's individual response to anticancer treatment. Anticancer drug efficacy has been tested on circulating tumor cells (CTCs) derived from patient blood samples after ex vivo expansion into CTC clusters. Current attempts to culture these primary cancer cells focus on long-term maintenance under growth factor supplements into cell lines, which usually takes >6 months and results in a CTC expansion efficiency of <20%...
January 2018: Nature Protocols
https://www.readbyqxmd.com/read/29213269/safety-and-immunogenicity-of-malaria-vectored-vaccines-given-with-routine-expanded-program-on-immunization-vaccines-in-gambian-infants-and-neonates-a-randomized-controlled-trial
#19
Victorine A Mensah, Sophie Roetynck, Ebrima K Kanteh, Georgina Bowyer, Amy Ndaw, Francis Oko, Carly M Bliss, Ya Jankey Jagne, Riccardo Cortese, Alfredo Nicosia, Rachel Roberts, Flavia D'Alessio, Odile Leroy, Babacar Faye, Beate Kampmann, Badara Cisse, Kalifa Bojang, Stephen Gerry, Nicola K Viebig, Alison M Lawrie, Ed Clarke, Egeruan B Imoukhuede, Katie J Ewer, Adrian V S Hill, Muhammed O Afolabi
Background: Heterologous prime-boost vaccination with chimpanzee adenovirus 63 (ChAd63) and modified vaccinia virus Ankara (MVA) encoding multiple epitope string thrombospondin-related adhesion protein (ME-TRAP) has shown acceptable safety and promising immunogenicity in African adult and pediatric populations. If licensed, this vaccine could be given to infants receiving routine childhood immunizations. We therefore evaluated responses to ChAd63 MVA ME-TRAP when co-administered with routine Expanded Program on Immunization (EPI) vaccines...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29210833/influence-of-injection-drug-use-related-hiv-acquisition-on-cd4-response-to-first-antiretroviral-therapy-regimen-among-virally-suppressed-individuals
#20
Keri L Calkins, Catherine R Lesko, Geetanjali Chander, Richard D Moore, Bryan Lau
BACKGROUND: The inflammatory effects of injection drug use may result in an impaired immune response to antiretroviral therapy (ART). We examined CD4 response to first ART regimen among individuals in routine HIV care, stratified by injection drug use-related HIV acquisition. SETTING: Cohort study including patients who initiated ART between 2000-2015 in the Johns Hopkins HIV Clinic. METHODS: We followed individuals from ART initiation until death, loss to follow-up, loss of viral load suppression (<500 copies/mL) or administrative censoring...
November 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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