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Cardiac arrhythmias

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https://www.readbyqxmd.com/read/28918214/efficient-noise-tolerant-estimation-of-heart-rate-variability-using-single-channel-photoplethysmography
#1
Reza Firoozabadi, Eric D Helfenbein, Saeed Babaeizadeh
BACKGROUND: The feasibility of using photoplethysmography (PPG) for estimating heart rate variability (HRV) has been the subject of many recent studies with contradicting results. Accurate measurement of cardiac cycles is more challenging in PPG than ECG due to its inherent characteristics. METHODS: We developed a PPG-only algorithm by computing a robust set of medians of the interbeat intervals between adjacent peaks, upslopes, and troughs. Abnormal intervals are detected and excluded by applying our criteria...
August 18, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28917559/predictors-and-outcomes-of-cardiac-resynchronization-therapy-extended-to-the-second-generator
#2
Xuping Li, Dachun Yang, Fred Kusumoto, Win-Guang Shen, Siva Mulpuru, Shenghua Zhou, Jinjun Liang, Gang Wu, Mei Yang, Jin-Qu Liu, Paul A Friedman, Yong-Mei Cha
BACKGROUND: A proportion of patients who receive cardiac resynchronization therapy (CRT) with defibrillator (CRT-D) live to receive a second generator. Controversy exists on whether an implantable cardioverter-defibrillator (ICD) should be offered to patients who have normalized or near normalized left ventricular ejection fraction (LVEF) at the time of generator replacement (GR). OBJECTIVE: To evaluate incidence of appropriate ICD therapy after CRT-D GR. METHODS: This series involved 1,026 consecutive patients who underwent CRT-D implant between January 2002 and December 2012...
September 13, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28917558/cardiac-sympathectomy-for-the-management-of-ventricular-arrhythmias-refractory-to-catheter-ablation
#3
Travis Richardson, Ricardo Lugo, Pablo Saavedra, George Crossley, Walter Clair, Sharon Shen, Juan Carlos Estrada, Jay Montgomery, M Benjamin Shoemaker, Christopher Ellis, Gregory F Michaud, Eric Lambright, Arvindh Kanagasundram
BACKGROUND: Catheter ablation is now a mainstay of therapy for ventricular arrhythmias (VA). However, there are scenarios where either physiologic or anatomical factors make ablation less likely to be successful. OBJECTIVES: To demonstrate that cardiac sympathetic denervation (CSD) may be an alternate therapy for patients with difficult to ablate VA. METHODS: We identified all patients referred for CSD at a single center for indications other than LQTS and CPVT who had failed catheter ablation...
September 13, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28917556/increased-risk-of-ventricular-arrhythmias-in-survivors-of-out-of-hospital-cardiac-arrest-with-chronic-total-coronary-occlusion
#4
Sing-Chien Yap, Rafi Sakhi, Dominic Amj Theuns, Yunus E Yasar, Rohit E Bhagwandien, Roberto Diletti, Felix Zijlstra, Tamas Szili-Torok
BACKGROUND: A chronic total occlusion (CTO) is common in out-of-hospital cardiac arrest (OHCA) survivors with coronary artery disease. It is unclear whether a CTO contributes to ventricular arrhythmias in this population. OBJECTIVE: This study sought to evaluate the impact of unrevascularized CTO's on the occurrence of appropriate implantable cardioverter-defibrillator (ICD) therapy and all-cause mortality in OHCA survivors with coronary artery disease. METHODS: This was a retrospective study that included all consecutive OHCA survivors with coronary artery disease who received an ICD from 1999 until 2015...
September 13, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28917093/molecular-cloning-and-functional-expression-of-the-k-channel-kv7-1-and-the-regulatory-subunit-kcne1-from-equine-myocardium
#5
Philip J Pedersen, Kirsten B Thomsen, Jon B Flak, Maria A Tejada, Frank Hauser, Dagmar Trachsel, Rikke Buhl, Theodore Kalbfleisch, Michael Scott DePriest, James N MacLeod, Kirstine Calloe, Dan A Klaerke
BACKGROUND: The voltage-gated K(+)-channel KV7.1 and the subunit KCNE1, encoded by the KCNQ1 and KCNE1 genes, respectively, are responsible for termination of the cardiac action potential. In humans, mutations in these genes can predispose patients to arrhythmias and sudden cardiac death (SCD). AIM: To characterize equine KV7.1/KCNE1 currents and compare them to human KV7.1/KCNE1 currents to determine whether KV7.1/KCNE1 plays a similar role in equine and human hearts...
September 11, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28917022/epidemiology-pathogenesis-and-management-of-takotsubo-syndrome
#6
REVIEW
Shams Y-Hassan, Per Tornvall
Takotsubo syndrome is a recently recognized acute cardiac disease entity with a clinical presentation resembling that of an acute coronary syndrome. The typical takotsubo syndrome patient has a unique circumferential left (bi-) ventricular contraction abnormality profile that extends beyond a coronary artery supply territory and appears to follow the anatomical cardiac sympathetic innervation. The syndrome predominantly affects postmenopausal women and is often preceded by emotional or physical stress. Patients with predisposing factors such as malignancy and other chronic comorbidities are more prone to suffer from takotsubo syndrome...
September 15, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28916638/pharmacological-and-physiological-assessment-of-serotonin-formation-and-degradation-in-isolated-preparations-from-mouse-and-human-heart
#7
Ulrich Gergs, Franziska Jung, Igor B Buchwalow, Britt Hofmann, Andreas Simm, Hendrik Treede, Joachim Neumann
Using transgenic mice (TG) that overexpress the human 5-HT4a-receptor specifically in cardiomyocytes, we wanted to know whether 5-HT can be formed and degraded in the mammalian heart and whether this can likewise lead to inotropic and chronotropic effects in this TG model. We noted that the 5-HT precursor, 5-hydroxy-tryptophan (5-HTP), can exert inotropic and chronotropic effects in cardiac preparations from TG but not from wild type (WT): similar results were found in human atrial preparations, as well as in intact TG animals using echocardiography...
September 15, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28916174/evaluation-of-beat-to-beat-ventricular-repolarization-lability-from-standard-12-lead-ecg-during-acute-myocardial-ischemia
#8
Salah S Al-Zaiti, Mohammad Alrawashdeh, Christian Martin-Gill, Clifton Callaway, David Mortara, Jan Nemec
BACKGROUND: Acute myocardial ischemia is a common cause of ventricular arrhythmias, yet recent ECG methods predicting susceptibility to ventricular tachyarrhythmia have not been fully evaluated during spontaneous ischemia. We sought to evaluate the clinical utility of alternans and non-alternans components of repolarization variability from the standard 10-second 12-lead ECG signals to risk stratify patients with acute chest pain. METHODS: We enrolled consecutive, non-traumatic, chest pain patients transported through Emergency Medical Services (EMS) to three tertiary care hospitals with cardiac catheterization lab capabilities in Pittsburgh, PA...
August 10, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28916127/open-thoracic-and-thoraco-abdominal-aortic-repair-in-patients-with-connective-tissue-disease
#9
Paula R Keschenau, Drosos Kotelis, Jeroen Bisschop, Mohammad E Barbati, Jochen Grommes, Barend Mees, Alexander Gombert, Arnoud G Peppelenbosch, Geert Willem H Schurink, Johannes Kalder, Michael J Jacobs
OBJECTIVE/BACKGROUND: The aim is to present current results of open complex aortic repair in patients with connective tissue disease (CTD). METHODS: This was a retrospective cross-border, single centre study. From February 2000 to April 2016 72 aortic operations were performed on 65 patients with CTD (41 male, median age 41 years [range 19-70 years]). Fifty-six patients (86%) underwent at least one previous aortic repair (71 open, four endovascular), including 33 patients (51%) operated before at the site of the procedure reported here...
September 12, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28915139/left-and-right-ventricular-morphology-function-and-late-gadolinium-enhancement-extent-and-localization-change-with-different-clinical-presentation-of-acute-myocarditis-data-from-the-italian-multicenter-study-on-myocarditis-itamy
#10
Gianluca Di Bella, Giovanni Camastra, Lorenzo Monti, Santo Dellegrottaglie, Paolo Piaggi, Claudio Moro, Alessia Pepe, Chiara Lanzillo, Gianluca Pontone, Martina Perazzolo Marra, Mauro Di Roma, Alessandra Scatteia, Giovanni D Aquaro
AIMS: Poor data exist about cardiac magnetic resonance (CMR) findings in a large sample of acute myocarditis with different clinical presentations (heart failure, arrhythmias, and infarct-like presentation). METHODS: Five hundred and forty-three in-patients with a clinical suspected of acute myocarditis confirmed by CMR were enrolled. The clinical indications to perform CMR were chest pain and/or dyspnea and/or palpitations, or effort intolerance/malaise in the last month; elevated troponin and/or new ventricular dysfunction, and/or new ECG abnormalities; and suspected inflammatory cause...
September 14, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28914660/mediterranean-diet-impact-on-cardiovascular-diseases-a-narrative-review
#11
Anna V Mattioli, Pasquale Palmiero, Olivia Manfrini, Paolo E Puddu, Savina Nodari, Alessandra Dei Cas, Giuseppe Mercuro, Domenico Scrutinio, Pietro Palermo, Susanna Sciomer, Simona Di Francesco, Giuseppina Novo, Salvatore Novo, Roberto F E Pedretti, Annapaola Zito, Gianfranco Parati, Roberto Pedrinelli, Alberto Farinetti, Maria Maiello, Federica Moscucci, Raffaele L Tenaglia, Vincenzo Sucato, Marco Triggiani, Lucia Cugusi, Pietro Scicchitano, Pier S Saba, Marco M Ciccone
: Cardiovascular disease (CVD) accounts for more than 17 million deaths per year worldwide. It has been estimated that the influence of lifestyle on CVD mortality amounts to 13.7% for smoking, 13.2% for poor diet, and 12% for inactive lifestyle. These results deeply impact both the healthy status of individuals and their skills in working. The impact of CVD on productivity loss accounts for the 24% in total costs for CVD management.Mediterranean diet (MedD) can positively impact on natural history of CVD. It is characterized by a relatively high consumption of inexpensive and genuine food such as cereals, vegetables, legumes, nuts, fish, fresh fruits, and olive oil as the principal source of fat, low meat consumption and low-to-moderate consumption of milk, dairy products, and wine...
September 12, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28912206/clinical-yield-of-familial-screening-after-sudden-death-in-young-subjects-the-french-experience
#12
Pauline Quenin, Florence Kyndt, Philippe Mabo, Jacques Mansourati, Dominique Babuty, Aurélie Thollet, Béatrice Guyomarch, Richard Redon, Julien Barc, Jean-Jacques Schott, Frederic Sacher, Vincent Probst, Jean Baptiste Gourraud
BACKGROUND: After sudden cardiac death with negative autopsy, clinical screening of relatives identifies a high proportion of inherited arrhythmia syndrome. However, the efficacy of this screening in families not selected by autopsy has never been assessed. We aim to investigate the value of clinical screening in relatives of all subjects who died suddenly before 45 years of age. METHODS AND RESULTS: One hundred and three consecutive families who experienced unexplained sudden cardiac death before 45 years of age were included from May 2009 to December 2014 in a prospective multicenter registry...
September 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28912183/arrhythmogenic-cardiomyopathy
#13
REVIEW
Domenico Corrado, Cristina Basso, Daniel P Judge
Arrhythmogenic cardiomyopathy is an inherited heart muscle disorder, predisposing to sudden cardiac death, particularly in young patients and athletes. Pathological features include loss of myocytes and fibrofatty replacement of right ventricular myocardium; biventricular involvement is often observed. It is a cell-to-cell junction cardiomyopathy, typically caused by genetically determined abnormalities of cardiac desmosomes, which leads to detachment of myocytes and alteration of intracellular signal transduction...
September 15, 2017: Circulation Research
https://www.readbyqxmd.com/read/28912180/dilated-cardiomyopathy-genetic-determinants-and-mechanisms
#14
REVIEW
Elizabeth M McNally, Luisa Mestroni
Nonischemic dilated cardiomyopathy (DCM) often has a genetic pathogenesis. Because of the large number of genes and alleles attributed to DCM, comprehensive genetic testing encompasses ever-increasing gene panels. Genetic diagnosis can help predict prognosis, especially with regard to arrhythmia risk for certain subtypes. Moreover, cascade genetic testing in family members can identify those who are at risk or with early stage disease, offering the opportunity for early intervention. This review will address diagnosis and management of DCM, including the role of genetic evaluation...
September 15, 2017: Circulation Research
https://www.readbyqxmd.com/read/28912075/ventricular-repolarization-disturbances-after-high-dose-intravenous-methylprednisolone-theraphy
#15
Gokhan Altunbas, Murat Sucu, Orhan Zengin
OBJECTIVE: There are no randomized trials evaluating the effects of pulse steroid treatment on cardiac electrophysiologic functions. The data are limited only to case series. In this study, we sought to evaluate the effects of high dose intravenous methylprednisolone therapy on indices of ventricular repolarization. METHODS: Fifty patients with various autoimmune and inflammatory disorders were enrolled to the study. Electrocardiography (ECG) was obtained 4h before and 12h after the pulse steroid treatment...
August 1, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28912073/mapping-of-ventricular-arrhythmias-using-a-novel-noninvasive-epicardial-and-endocardial-electrophysiology-system
#16
Alexey Tsyganov, Erik Wissner, Andreas Metzner, Sergey Mironovich, Maria Chaykovskaya, Vitaly Kalinin, Mikhail Chmelevsky, Christine Lemes, Karl-Heinz Kuck
INTRODUCTION: The aim of this study was to assess the use of a novel noninvasive epicardial and endocardial electrophysiology system (NEEES) for mapping of ventricular arrhythmias. METHODS: Eight patients (2 females, mean age 50±17 years) with ischemic (n=3) and nonischemic (n=5) cardiomyopathy and inducible ventricular arrhythmias during electrophysiology study were enrolled. Noninvasive mapping of ventricular arrhythmias was performed using the NEEES based on body-surface electrocardiograms and computed tomography imaging data...
August 1, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28912057/apnoeic-oxygenation-during-intubation-in-the-intensive-care-unit-a-systematic-review-and-meta-analysis
#17
REVIEW
Matthew J Binks, Rhys S Holyoak, Thomas M Melhuish, Ruan Vlok, Anthony Hodge, Thomas Ryan, Leigh D White
Hypoxaemia increases the risk of cardiac arrest and mortality during intubation. The reduced physiological reserve and reduced efficacy of pre-oxygenation in intensive care patients makes their intubation particularly dangerous. Apnoeic oxygenation is a promising means of preventing hypoxaemia in this setting. We sought to ascertain whether apnoeic oxygenation reduces the incidence of hypoxaemia when used during endotracheal intubation in the intensive care unit (ICU). A systematic review of five databases for all relevant studies published up to November 2016 was performed...
September 11, 2017: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/28911997/heart-type-fatty-acid-binding-protein-in-cardiovascular-disease-a-systemic-review
#18
REVIEW
Yoichiro Otaki, Tetsu Watanabe, Isao Kubota
Fatty acid-binding proteins, whose clinical applications have been studied, are a family of proteins that reflect tissue injury. Heart-type fatty acid-binding protein (H-FABP) is a marker of ongoing myocardial damage and useful for early diagnosis of acute myocardial infarction (AMI). In the past decade, compared to other cardiac enzymes, H-FABP has shown more promise as an early detection marker for AMI. However, the role of H-FABP is being re-examined due to recent refinement in the search for newer biomarkers, and greater understanding of the role of high-sensitivity troponin...
September 11, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28911189/long-working-hours-as-a-risk-factor-for-atrial-fibrillation-a-multi-cohort-study
#19
Mika Kivimäki, Solja T Nyberg, G David Batty, Ichiro Kawachi, Markus Jokela, Lars Alfredsson, Jakob B Bjorner, Marianne Borritz, Hermann Burr, Nico Dragano, Eleonor I Fransson, Katriina Heikkilä, Anders Knutsson, Markku Koskenvuo, Meena Kumari, Ida E H Madsen, Martin L Nielsen, Maria Nordin, Tuula Oksanen, Jan H Pejtersen, Jaana Pentti, Reiner Rugulies, Paula Salo, Martin J Shipley, Sakari Suominen, Töres Theorell, Jussi Vahtera, Peter Westerholm, Hugo Westerlund, Andrew Steptoe, Archana Singh-Manoux, Mark Hamer, Jane E Ferrie, Marianna Virtanen, Adam G Tabak
Aims: Studies suggest that people who work long hours are at increased risk of stroke, but the association of long working hours with atrial fibrillation, the most common cardiac arrhythmia and a risk factor for stroke, is unknown. We examined the risk of atrial fibrillation in individuals working long hours (≥55 per week) and those working standard 35-40 h/week. Methods and results: In this prospective multi-cohort study from the Individual-Participant-Data Meta-analysis in Working Populations (IPD-Work) Consortium, the study population was 85 494 working men and women (mean age 43...
September 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28906362/are-we-ever-too-old-characteristics-and-outcome-of-octogenarians-admitted-to-a-medical-intensive-care-unit
#20
Johanna Maria Muessig, Maryna Masyuk, Amir Movahed Nia, Marcus Franz, Bjoern Kabisch, Malte Kelm, Christian Jung
The aging population increases the demand of intensive care unit (ICU) treatments. However, the availability of ICU beds is limited. Thus, ICU admission of octogenarians is considered controversial. The population above 80 years is a very heterogeneous group though, and age alone might not be the best predictor. Aim of this study was to analyze resource consumption and outcome of octogenarians admitted to a medical ICU to identify reliable survival predictors in a senescent society.This retrospective observational study analyzes 930 octogenarians and 5732 younger patients admitted to a medical ICU...
September 2017: Medicine (Baltimore)
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