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urinary bladder matrix, UBM

A Costa, J D Naranjo, N J Turner, I T Swinehart, B D Kolich, S A Shaffiey, R Londono, T J Keane, J E Reing, S A Johnson, S F Badylak
The use of synthetic surgical mesh materials has been shown to decrease the incidence of hernia recurrence, but can be associated with undesirable effects such as infection, chronic discomfort, and adhesion to viscera. Surgical meshes composed of extracellular matrix (i.e., biologically-derived mesh) are an alternative to synthetic meshes and can reduce some of these undesirable effects but are less frequently used due to greater cost and perceived inadequate strength as the mesh material degrades and is replaced by host tissue...
November 2016: Biomaterials
Jenna L Dziki, Derek S Wang, Catalina Pineda, Brian M Sicari, Theresa Rausch, Stephen F Badylak
The host response to biomaterials is a critical determinant of their success or failure in tissue-repair applications. Macrophages are among the first responders in the host response to biomaterials and have been shown to be predictors of downstream tissue remodeling events. Biomaterials composed of mammalian extracellular matrix (ECM) in particular, have been shown to promote distinctive and constructive remodeling outcomes when compared to their synthetic counterparts, a property that has been largely attributed to their ability to modulate the host macrophage response...
September 6, 2016: Journal of Biomedical Materials Research. Part A
Kent C Sasse, David L Warner, Ellen Ackerman, Jared Brandt
BACKGROUND AND OBJECTIVES: Hiatal hernias are repaired laparoscopically with increasing use of reinforcement material. Both synthetic and biologically derived materials reduce the recurrence rate compared to primary crural repair. Synthetic mesh introduces complications, such as mesh erosion, fibrosis, and infection. Urinary bladder matrix (UBM) represents a biologically derived material for use in hiatal hernia repair reinforcement with the potential to improve durability of repair without incurring the risks of other reinforcement materials...
April 2016: JSLS: Journal of the Society of Laparoendoscopic Surgeons
Sara Gonçalves, Inês Patrício Rodrigues, Jorge Padrão, João Pedro Silva, Vitor Sencadas, Senentxu Lanceros-Mendez, Henrique Girão, Francisco M Gama, Fernando Dourado, Lígia R Rodrigues
This work evaluated the effect of acetylated bacterial cellulose (ABC) substrates coated with urinary bladder matrix (UBM) on the behavior of retinal pigment epithelium (RPE), as assessed by cell adhesion, proliferation and development of cell polarity exhibiting transepithelial resistance and polygonal shaped-cells with microvilli. Acetylation of bacterial cellulose (BC) generated a moderate hydrophobic surface (around 65°) while the adsorption of UBM onto these acetylated substrates did not affect significantly the surface hydrophobicity...
March 1, 2016: Colloids and Surfaces. B, Biointerfaces
A M Eweida, M K Marei
The pronounced effect of extracellular matrix (ECM) scaffolds in supporting tissue regeneration is related mainly to their maintained 3D structure and their bioactive components. These decellularized matrix scaffolds could be revitalized before grafting via adding stem cells, fibroblasts, or keratinocytes to promote wound healing. We reviewed the online published literature in the last five years for the studies that performed ECM revitalization and discussed the results of these studies and the related literature...
2015: BioMed Research International
Andre R Massensini, Harmanvir Ghuman, Lindsey T Saldin, Christopher J Medberry, Timothy J Keane, Francesca J Nicholls, Sachin S Velankar, Stephen F Badylak, Michel Modo
UNLABELLED: Biomaterials composed of mammalian extracellular matrix (ECM) promote constructive tissue remodeling with minimal scar tissue formation in many anatomical sites. However, the optimal shape and form of ECM scaffold for each clinical application can vary markedly. ECM hydrogels have been shown to promote chemotaxis and differentiation of neuronal stem cells, but minimally invasive delivery of such scaffold materials to the central nervous system (CNS) would require an injectable form...
November 2015: Acta Biomaterialia
Amit Aurora, Janet L Roe, Benjamin T Corona, Thomas J Walters
Extracellular matrix (ECM) derived scaffolds continue to be investigated for the treatment of volumetric muscle loss (VML) injuries. Clinically, ECM scaffolds have been used for lower extremity VML repair; in particular, MatriStem™, a porcine urinary bladder matrix (UBM), has shown improved functional outcomes and vascularization, but limited myogenesis. However, efficacy of the scaffold for the repair of traumatic muscle injuries has not been examined systematically. In this study, we demonstrate that the porcine UBM scaffold when used to repair a rodent gastrocnemius musculotendinous junction (MTJ) and tibialis anterior (TA) VML injury does not support muscle tissue regeneration...
October 2015: Biomaterials
Marco Angelozzi, Martina Miotto, Letizia Penolazzi, Stefania Mazzitelli, Timothy Keane, Stephen F Badylak, Roberta Piva, Claudio Nastruzzi
A novel approach to produce artificial bone composites (microfibers) with distinctive features mimicking natural tissue was investigated. Currently proposed inorganic materials (e.g. apatite matrixes) lack self-assembly and thereby limit interactions between cells and the material. The present work investigates the feasibility of creating "bio-inspired materials" specifically designed to overcome certain limitations inherent to current biomaterials. We examined the dimensions, morphology, and constitutive features of a composite hydrogel which combined an alginate based microfiber with a gelatin solution or a particulate form of urinary bladder matrix (UBM)...
November 1, 2015: Materials Science & Engineering. C, Materials for Biological Applications
Erika Silva-Benítez, Eduardo Soto-Sáinz, Amaury Pozos-Guillen, José Geovanni Romero-Quintana, Maribel Aguilar-Medina, Alfredo Ayala-Ham, Eri Peña-Martínez, Rosalío Ramos-Payán, Héctor Flores
Extracellular matrix (ECM) is a rich network of proteins and proteoglycans that has proved to be very useful in tissue regeneration. Porcine ECM has been proposed as a biological scaffold, and urinary bladder matrix (UBM) has demonstrated superior biological properties; however, its use in human treatment requires ensuring that it is DNA free. Several protocols have been used for decellularization and to demonstrate the absence of DNA, but until now, a porcine housekeeping gene for quantifying DNA by real-time quantitative PCR (qPCR) has been limiting...
November 2015: In Vitro Cellular & Developmental Biology. Animal
Alexis Lanteri Parcells, Brenon Abernathie, Ramazi Datiashvili
BACKGROUND: Management of complicated open wounds represents a challenge when reconstructive options are not applicable. Urinary bladder matrix (UBM) provides a biocompatible material that allows inductivetissue remodeling. METHODS: The use of urinary bladder matrix inthe treatment of 5 patients with complicated open wounds that failed toheal with conventional therapy is presented. RESULTS: A 3-year old male sustained a second-degree oil burn measuring 8 cm x 4 cm to his dorsal forearm; UBM was applied weekly and the wound epithelialized in 3 weeks...
July 2014: Wounds: a Compendium of Clinical Research and Practice
A Callanan, N F Davis, T M McGloughlin, M T Walsh
Deployment of stent-grafts, derived from synthetic biomaterials, is an established minimally invasive approach for effectively treating abdominal aortic aneurysms (AAAs). However, a notable disadvantage associated with this surgical technique is migration of the deployed stent-graft due to poor biocompatibility and inadequate integration in vivo. Recently, tissue-engineered extracellular matrices (ECMs) have shown early promise as integrating stabilisation collars in this setting due to their ability to induce a constructive tissue remodelling response after in vivo implantation...
June 3, 2014: Journal of Biomechanics
Howard Kimmel, Michael Rahn, Thomas W Gilbert
A study involving 3 patients was performed to evaluate the efficacy of Matristem, an extracellular matrix scaffold derived from the porcine urinary bladder matrix (UBM), to promote natural healing in patients with severe, chronic wounds that did not respond well to standard wound management. In all cases, the wounds closed after only a few weeks of repeated treatments with UBM, with all patients showing complete epithelialization of the wound with limited formation of scar tissue by 13 weeks after first treatment...
September 2010: Journal of the American College of Certified Wound Specialists
Morimasa Kitamura, Shigeru Hirano, Shin-Ichi Kanemaru, Yoshiharu Kitani, Satoshi Ohno, Tsuyoshi Kojima, Tatsuo Nakamura, Juichi Ito, Clark A Rosen, Thomas W Gilbert
Acellular extracellular matrix scaffold derived from porcine urinary bladder (UBM) is decellularized material that has shown success for constructive remodelling of various tissues and organs. The regenerative effects of UBM were reported for the tympanic membrane, oesophagus, trachea, larynx, pleura and pericardium in animal studies, with promising results. The aim of this study was to investigate the regenerative effects of UBM on hemilarynx, using a canine model. A left partial hemilaryngectomy was performed and the surgical defects were reconstructed by insertion of UBM scaffold...
January 8, 2014: Journal of Tissue Engineering and Regenerative Medicine
Xuemei Fan, Yanzhou Wang, Yu Wang, Huicheng Xu
INTRODUCTION AND HYPOTHESES: Our aim was to compare histological and biomechanical effects of polypropylene (PP) mesh and porcine-derived, cross-linked urinary bladder matrix (cUBM) graft materials using a rabbit vaginal and abdominal model. METHODS: Forty rabbits were implanted with PP mesh (n = 20) or cUBM (n = 20) in the vagina and abdomen. Two grafts (PP or cUBM) of the same type were placed into each site, so each rabbit had four grafts. Grafts were harvested 12 weeks later and processed for histologic analysis and biomechanical testing...
May 2014: International Urogynecology Journal
Steve J Schomisch, Liming Yu, Yuhsin Wu, Eric M Pauli, Cassandra Cipriano, Amitabh Chak, Richard H Lash, Jeffrey L Ponsky, Jeffrey M Marks
BACKGROUND AND STUDY AIMS: Endoscopic mucosal resection (EMR) offers a minimally invasive therapy for advanced esophageal dysplasia and early cancers but stricture formation limits its applicability. We aimed at assessing the efficacy of placement of a commercially available biological mesh for preventing stricture formation following esophageal EMR. METHODS: 25 swine were submitted to circumferential esophageal EMR with 10-cm extent and divided in five groups: one group with EMR only (control); one receiving an uncovered stent (stent-only group); and three groups receiving a stent covered with one of three extracellular matrices, namely small intestine submucosa (SIS group), acellular dermal matrix (ADM group), or urinary bladder matrix (UBM group)...
February 2014: Endoscopy
A Callanan, N F Davis, T M McGloughlin, M T Walsh
Tubularized porcine extracellular matrices (ECMs) are under investigation as adjuvant scaffolds for endovascular aneurismal repair (EVAR). Limitations with tubularized ECMs in this setting include difficulties in achieving a confluent endothelium on the scaffold's luminal surface prior to in vivo implantation. In this in vitro study a rotational "cell-seeding rig" (RCR) was constructed to assess the potential for endothelialization of tubular ECM constructs. Human aortic endothelial cells (HAECs) were cultured onto the luminal surfaces of tubular porcine urinary bladder matrix (UBM) scaffolds and rotated in the RCR at experimental rotational speeds...
May 2014: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Nathaniel T Remlinger, Thomas W Gilbert, Masahiro Yoshida, Brogan N Guest, Ryotaro Hashizume, Michelle L Weaver, William R Wagner, Bryan N Brown, Kimimasa Tobita, Peter D Wearden
The current prevalence and severity of heart defects requiring functional replacement of cardiac tissue pose a serious clinical challenge. Biologic scaffolds are an attractive tissue engineering approach to cardiac repair because they avoid sensitization associated with homograft materials and theoretically possess the potential for growth in similar patterns as surrounding native tissue. Both urinary bladder matrix (UBM) and cardiac ECM (C-ECM) have been previously investigated as scaffolds for cardiac repair with modest success, but have not been compared directly...
July 2013: Organogenesis
L M Davis, A Callanan, G T Carroll, B J Doyle, M T Walsh, T M McGloughlin
Tissue engineered acellular vascular grafts are an emerging concept in the development of vascular prostheses for the minimally invasive treatment of cardiovascular diseases. Extracellular matrix (ECM) scaffolds, such as small intestinal submucosa (SIS) and urinary bladder matrix (UBM), offer many advantages over currently available synthetic devices. However, storage of such biomaterials can unduly influence the scaffold properties. This study evaluated the effects of up to 16 weeks hydrated storage on the mechanical and cellular performance of stented and unstented tubular scaffolds...
January 2014: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Niall F Davis, Daniel N Coakley, Anthony Callanan, Hugh D Flood, Tim M McGloughlin
INTRODUCTION AND HYPOTHESIS: Tissue-engineered biomaterials have shown recent promise as adjuvant scaffolds for treating stress urinary incontinence (SUI). The objective of the present study was to compare their mechanical and regenerative properties with synthetic biomaterials in this urogynaecological setting. METHODS: The biomechanical properties of polypropylene (Serasis®; n = 12), four-ply urinary bladder matrix (UBM; n = 12) and four-ply small intestinal submucosa (SIS; n = 12) were determined with uni-axial tensile testing protocols and compared with stress-strain curves...
December 2013: International Urogynecology Journal
Xuemei Fan, Senlin Xu, Yanzhou Wang, Shengping Li, Yu Wang, Huicheng Xu
The high failure rate of traditional procedures of repairing pelvic organ prolapse by using sutures pushes multiple transvaginal mesh delivery systems into the marketplace; however, these are currently without optimal clinical results. We observed the short-term histological changes and the effects of Th1/Th2 cytokines after the implantation in rabbit abdominal walls of five materials, i.e., porcine urinary bladder matrix (UBM), cross-linked UBM, polypropylene mesh, composite cross-linked UBM, and composite UBM, and explored the feasibility of their application to pelvic reconstructive surgery...
August 2013: Biomedizinische Technik. Biomedical Engineering
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