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urinary bladder matrix, UBM

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https://www.readbyqxmd.com/read/28583764/proteomic-composition-and-immunomodulatory-properties-of-urinary-bladder-matrix-scaffolds-in-homeostasis-and-injury
#1
REVIEW
Kaitlyn Sadtler, Sven D Sommerfeld, Matthew T Wolf, Xiaokun Wang, Shoumyo Majumdar, Liam Chung, Dhanashree S Kelkar, Akhilesh Pandey, Jennifer H Elisseeff
Urinary bladder matrix (UBM) is used clinically for management of wounds and reinforcement of surgical soft tissue repair, among other applications. UBM consists of the lamina propria and basal lamina of the porcine urinary bladder, and is decellularized as part of the process to manufacture the medical device. UBM is composed mainly of Collagen I, but also contains a wide variety of fibrillar and basement membrane collagens, glycoproteins, proteoglycans and ECM-associated factors. Upon application of the biomaterial in a traumatic or non-traumatic setting in a mouse model, there is a cascade of immune cells that respond to the damaged tissue and biomaterial...
June 2, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28400698/laparoscopic-rectopexy-with-urinary-bladder-xenograft-reinforcement
#2
Aradhana Mehta, Rami Afshar, David L Warner, Amy Gardner, Ellen Ackerman, Jared Brandt, Kent C Sasse
BACKGROUND AND OBJECTIVES: Rectal prolapse is often repaired laparoscopically, frequently with the use of reinforcement material. Both synthetic and biologically derived materials reduce recurrence rate compared to primary suture repair. Synthetic mesh introduces potential complications such as mesh erosion, fibrosis, and infection. Urinary bladder matrix (UBM) represents a biologically derived material for reinforcement of rectal prolapse repair with the potential to improve durability without risks of synthetic materials...
January 2017: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/28328634/bridging-the-gap-engineered-porcine-derived-urinary-bladder-matrix-conduits-as-a-novel-scaffold-for-peripheral-nerve-regeneration
#3
Lyly Nguyen, Ashkan Afshari, Nathaniel D Kelm, Alonda C Pollins, R Bruce Shack, Mark D Does, Wesley P Thayer
PURPOSE: This study aims to compare engineered nerve conduits constructed from porcine-derived urinary bladder matrix (UBM) with the criterion-standard nerve autografts, for segmental loss peripheral nerve repairs. METHODS: Forty-eight Sprague-Dawley rats were divided into 2 groups. All underwent a 10-mm sciatic nerve gap injury. This was repaired using either (1) reverse autograft-the 10-mm cut segment was oriented 180 degrees and used to coapt the proximal and distal stumps or (2) UBM conduit-the 10-mm nerve gap was bridged with UBM conduit...
June 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28277472/transvaginal-repair-of-complex-rectovaginal-fistulas-using-the-porcine-urinary-bladder-matrix-as-an-augmenting-graft
#4
Hemikaa Devakumar, Neeraja Chandrasekaran, Alexandriah Alas, Laura Martin, G Willy Davila, Eric Hurtado
BACKGROUND: After the US Food and Drug Administration issued a safety warning concerning vaginal mesh implants in 2008, their use in correction of pelvic floor defects have decreased in the United States (http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm479732.htm). However, we are still treating patients who have had complications associated with their use, rectovaginal fistulas (RVFs) being one of them. Rectovaginal fistulas are considered complex if greater than 2.5 cm, recurrent, associated with inflammatory bowel disease, or if they are proximal in location...
May 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28267677/diabetic-foot-ulcers-treated-with-porcine-urinary-bladder-extracellular-matrix-and-total-contact-cast-interim-analysis-of-a-randomized-controlled-trial
#5
Oscar M Alvarez, Tashara Smith, Thomas W Gilbert, Neh J Onumah, Martin E Wendelken, Rachelle Parker, Lee Markowitz
OBJECTIVE: To evaluate the effectiveness of a porcine urinary bladder-derived extracellular matrix (UBM) for the treatment of recalcitrant, neuropathic diabetic foot ulcers (DFUs). MATERIALS AND METHODS: This prospective, parallel, randomized, single-center study involving 17 subjects was performed in an outpatient wound care center setting. Each subject with a DFU was randomized (2:1) to receive the urinary bladder matrix (UBM) plus offloading with a total contact cast (TCC) or standard care (nonadherent dressing plus TCC)...
February 27, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28091712/two-cases-of-female-urethral-reconstruction-with-acellular-porcine-urinary-bladder-matrix
#6
Sana Ansari, Mickey Karram
INTRODUCTION AND HYPOTHESIS: Female urethral reconstruction via the traditional routes can be limiting for various reasons. Current literature on the use of acellular biologic grafts derived from viscera for female urethral reconstruction is limited. We present two cases of women with complete loss of their posterior urethra presenting for urethral reconstruction. METHODS: Two cases of urethral reconstruction using acellular porcine urinary bladder matrix (UBM), along with labial fat pad transposition and biologic pubovaginal sling are presented...
January 13, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/27786165/inflammatory-response-to-dextrin-based-hydrogel-associated-with-human-mesenchymal-stem-cells-urinary-bladder-matrix-and-bonelike-%C3%A2-granules-in-rat-subcutaneous-implants
#7
Dina M Silva, Ana Rita Caseiro, Irina Amorim, Isabel Pereira, Fátima Faria, Tiago Pereira, José Domingos Santos, Francisco Miguel Gama, Ana Colette Maurício
Increasing relevance has been attributed to hydrogels due to their ability to provide an extracellular matrix (ECM)-like environment for cellular adhesion and proliferation, acting as mechanical scaffolds for tissue remodeling or as delivery matrices. In vivo biocompatibility of a hybrid dextrin hydrogel produced from oxidized dextrin and adipic acid dihydrazide and its combinations with human mesenchymal stem cells (hMSCs), ECM from a porcine bladder (urinary bladder matrix) and ceramic granules (Bonelike(®)), was evaluated following ISO 10993 after subcutaneous implantation in a rat model...
October 27, 2016: Biomedical Materials
https://www.readbyqxmd.com/read/27778194/intra-articular-injection-of-urinary-bladder-matrix-reduces-osteoarthritis-development
#8
Heather N Jacobs, Sona Rathod, Matthew T Wolf, Jennifer H Elisseeff
Micronized porcine urinary bladder matrix (UBM) is an extracellular matrix biomaterial that has immunomodulatory and pro-regenerative properties. The objective of this study was to assess the ability of UBM to alter disease progression in a mouse model of post-traumatic osteoarthritis (OA). Ten-week-old wild-type C57BL/6 male mice underwent anterior cruciate ligament transection (ACLT) to induce OA. Two weeks after ACLT, UBM (50 mg/mL) or saline was injected into the mouse joint. At 4 and 8 weeks post-ACLT, cartilage integrity was assessed using OARSI scoring of histology, pain was evaluated, and joints were harvested for quantitative RT-PCR analysis of cartilage-specific and inflammatory gene expression...
January 2017: AAPS Journal
https://www.readbyqxmd.com/read/27619242/mechanical-strength-vs-degradation-of-a-biologically-derived-surgical-mesh-over-time-in-a-rodent-full-thickness-abdominal-wall-defect
#9
A Costa, J D Naranjo, N J Turner, I T Swinehart, B D Kolich, S A Shaffiey, R Londono, T J Keane, J E Reing, S A Johnson, S F Badylak
The use of synthetic surgical mesh materials has been shown to decrease the incidence of hernia recurrence, but can be associated with undesirable effects such as infection, chronic discomfort, and adhesion to viscera. Surgical meshes composed of extracellular matrix (i.e., biologically-derived mesh) are an alternative to synthetic meshes and can reduce some of these undesirable effects but are less frequently used due to greater cost and perceived inadequate strength as the mesh material degrades and is replaced by host tissue...
November 2016: Biomaterials
https://www.readbyqxmd.com/read/27601305/solubilized-extracellular-matrix-bioscaffolds-derived-from-diverse-source-tissues-differentially-influence-macrophage-phenotype
#10
Jenna L Dziki, Derek S Wang, Catalina Pineda, Brian M Sicari, Theresa Rausch, Stephen F Badylak
The host response to biomaterials is a critical determinant of their success or failure in tissue-repair applications. Macrophages are among the first responders in the host response to biomaterials and have been shown to be predictors of downstream tissue remodeling events. Biomaterials composed of mammalian extracellular matrix (ECM) in particular have been shown to promote distinctive and constructive remodeling outcomes when compared to their synthetic counterparts, a property that has been largely attributed to their ability to modulate the host macrophage response...
January 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27186066/hiatal-hernia-repair-with-novel-biological-graft-reinforcement
#11
Kent C Sasse, David L Warner, Ellen Ackerman, Jared Brandt
BACKGROUND AND OBJECTIVES: Hiatal hernias are repaired laparoscopically with increasing use of reinforcement material. Both synthetic and biologically derived materials reduce the recurrence rate compared to primary crural repair. Synthetic mesh introduces complications, such as mesh erosion, fibrosis, and infection. Urinary bladder matrix (UBM) represents a biologically derived material for use in hiatal hernia repair reinforcement with the potential to improve durability of repair without incurring the risks of other reinforcement materials...
April 2016: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/26689643/acetylated-bacterial-cellulose-coated-with-urinary-bladder-matrix-as-a-substrate-for-retinal-pigment-epithelium
#12
Sara Gonçalves, Inês Patrício Rodrigues, Jorge Padrão, João Pedro Silva, Vitor Sencadas, Senentxu Lanceros-Mendez, Henrique Girão, Francisco M Gama, Fernando Dourado, Lígia R Rodrigues
This work evaluated the effect of acetylated bacterial cellulose (ABC) substrates coated with urinary bladder matrix (UBM) on the behavior of retinal pigment epithelium (RPE), as assessed by cell adhesion, proliferation and development of cell polarity exhibiting transepithelial resistance and polygonal shaped-cells with microvilli. Acetylation of bacterial cellulose (BC) generated a moderate hydrophobic surface (around 65°) while the adsorption of UBM onto these acetylated substrates did not affect significantly the surface hydrophobicity...
March 1, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/26509165/naturally-occurring-extracellular-matrix-scaffolds-for-dermal-regeneration-do-they-really-need-cells
#13
REVIEW
A M Eweida, M K Marei
The pronounced effect of extracellular matrix (ECM) scaffolds in supporting tissue regeneration is related mainly to their maintained 3D structure and their bioactive components. These decellularized matrix scaffolds could be revitalized before grafting via adding stem cells, fibroblasts, or keratinocytes to promote wound healing. We reviewed the online published literature in the last five years for the studies that performed ECM revitalization and discussed the results of these studies and the related literature...
2015: BioMed Research International
https://www.readbyqxmd.com/read/26318805/concentration-dependent-rheological-properties-of-ecm-hydrogel-for-intracerebral-delivery-to-a-stroke-cavity
#14
Andre R Massensini, Harmanvir Ghuman, Lindsey T Saldin, Christopher J Medberry, Timothy J Keane, Francesca J Nicholls, Sachin S Velankar, Stephen F Badylak, Michel Modo
UNLABELLED: Biomaterials composed of mammalian extracellular matrix (ECM) promote constructive tissue remodeling with minimal scar tissue formation in many anatomical sites. However, the optimal shape and form of ECM scaffold for each clinical application can vary markedly. ECM hydrogels have been shown to promote chemotaxis and differentiation of neuronal stem cells, but minimally invasive delivery of such scaffold materials to the central nervous system (CNS) would require an injectable form...
November 2015: Acta Biomaterialia
https://www.readbyqxmd.com/read/26256250/an-acellular-biologic-scaffold-does-not-regenerate-appreciable-de-novo-muscle-tissue-in-rat-models-of-volumetric-muscle-loss-injury
#15
Amit Aurora, Janet L Roe, Benjamin T Corona, Thomas J Walters
Extracellular matrix (ECM) derived scaffolds continue to be investigated for the treatment of volumetric muscle loss (VML) injuries. Clinically, ECM scaffolds have been used for lower extremity VML repair; in particular, MatriStem™, a porcine urinary bladder matrix (UBM), has shown improved functional outcomes and vascularization, but limited myogenesis. However, efficacy of the scaffold for the repair of traumatic muscle injuries has not been examined systematically. In this study, we demonstrate that the porcine UBM scaffold when used to repair a rodent gastrocnemius musculotendinous junction (MTJ) and tibialis anterior (TA) VML injury does not support muscle tissue regeneration...
October 2015: Biomaterials
https://www.readbyqxmd.com/read/26249575/composite-ecm-alginate-microfibers-produced-by-microfluidics-as-scaffolds-with-biomineralization-potential
#16
Marco Angelozzi, Martina Miotto, Letizia Penolazzi, Stefania Mazzitelli, Timothy Keane, Stephen F Badylak, Roberta Piva, Claudio Nastruzzi
A novel approach to produce artificial bone composites (microfibers) with distinctive features mimicking natural tissue was investigated. Currently proposed inorganic materials (e.g. apatite matrixes) lack self-assembly and thereby limit interactions between cells and the material. The present work investigates the feasibility of creating "bio-inspired materials" specifically designed to overcome certain limitations inherent to current biomaterials. We examined the dimensions, morphology, and constitutive features of a composite hydrogel which combined an alginate based microfiber with a gelatin solution or a particulate form of urinary bladder matrix (UBM)...
November 1, 2015: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/26091631/quantification-of-dna-in-urinary-porcine-bladder-matrix-using-the-actb-gene
#17
Erika Silva-Benítez, Eduardo Soto-Sáinz, Amaury Pozos-Guillen, José Geovanni Romero-Quintana, Maribel Aguilar-Medina, Alfredo Ayala-Ham, Eri Peña-Martínez, Rosalío Ramos-Payán, Héctor Flores
Extracellular matrix (ECM) is a rich network of proteins and proteoglycans that has proved to be very useful in tissue regeneration. Porcine ECM has been proposed as a biological scaffold, and urinary bladder matrix (UBM) has demonstrated superior biological properties; however, its use in human treatment requires ensuring that it is DNA free. Several protocols have been used for decellularization and to demonstrate the absence of DNA, but until now, a porcine housekeeping gene for quantifying DNA by real-time quantitative PCR (qPCR) has been limiting...
November 2015: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/25860538/the-use-of-urinary-bladder-matrix-in-the-treatment-of-complicated-open-wounds
#18
Alexis Lanteri Parcells, Brenon Abernathie, Ramazi Datiashvili
BACKGROUND: Management of complicated open wounds represents a challenge when reconstructive options are not applicable. Urinary bladder matrix (UBM) provides a biocompatible material that allows inductivetissue remodeling. METHODS: The use of urinary bladder matrix inthe treatment of 5 patients with complicated open wounds that failed toheal with conventional therapy is presented. RESULTS: A 3-year old male sustained a second-degree oil burn measuring 8 cm x 4 cm to his dorsal forearm; UBM was applied weekly and the wound epithelialized in 3 weeks...
July 2014: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/24709565/the-effects-of-stent-interaction-on-porcine-urinary-bladder-matrix-employed-as-stent-graft-materials
#19
A Callanan, N F Davis, T M McGloughlin, M T Walsh
Deployment of stent-grafts, derived from synthetic biomaterials, is an established minimally invasive approach for effectively treating abdominal aortic aneurysms (AAAs). However, a notable disadvantage associated with this surgical technique is migration of the deployed stent-graft due to poor biocompatibility and inadequate integration in vivo. Recently, tissue-engineered extracellular matrices (ECMs) have shown early promise as integrating stabilisation collars in this setting due to their ability to induce a constructive tissue remodelling response after in vivo implantation...
June 3, 2014: Journal of Biomechanics
https://www.readbyqxmd.com/read/24527148/the-clinical-effectiveness-in-wound-healing-with-extracellular-matrix-derived-from-porcine-urinary-bladder-matrix-a-case-series-on-severe-chronic-wounds
#20
Howard Kimmel, Michael Rahn, Thomas W Gilbert
A study involving 3 patients was performed to evaluate the efficacy of Matristem, an extracellular matrix scaffold derived from the porcine urinary bladder matrix (UBM), to promote natural healing in patients with severe, chronic wounds that did not respond well to standard wound management. In all cases, the wounds closed after only a few weeks of repeated treatments with UBM, with all patients showing complete epithelialization of the wound with limited formation of scar tissue by 13 weeks after first treatment...
September 2010: Journal of the American College of Certified Wound Specialists
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