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Keywords Matrix producing metaplastic b...

Matrix producing metaplastic breast cancer

https://read.qxmd.com/read/38196420/large-solitary-lung-metastasis-of-a-matrix-producing-metaplastic-breast-carcinoma-a-diagnostic-challenge
#1
Rida Noor, Sigfred Lajara, Rohit Bhargava
Metaplastic breast carcinoma represents a diverse category of invasive breast cancers distinguished by the transformation of neoplastic epithelial cells into squamous cells or cells with mesenchymal appearance. Matrix-producing breast carcinoma is a variant of metaplastic breast carcinoma, an exceedingly uncommon malignancy accounting for less than 1% of all breast tumors. The precise origin of this tumor remains elusive; some molecular research points to a potential derivation from myoepithelial cells, while other studies emphasize the possibility of neoplastic transformation originating from multipotent stem cells...
December 2023: Curēus
https://read.qxmd.com/read/37274268/case-report-gastric-cancer-with-chondromyxoid-matrix-similar-matrix-producing-metaplastic-breast-carcinoma-report-of-an-undescribed-entity
#2
Xiaoyan Wu, Huihua He, Lina Zhao, Zhi Zeng, Jingping Yuan
Gastric cancer is a malignant epithelial neoplasm of the stomach, including adenocarcinoma, squamous cell carcinoma, adenosquamous carcinoma, undifferentiated carcinoma, gastroblastoma and neuroendocrine neoplasms, without gastric metaplastic carcinoma. We describe a 69-year-old male patient with gastric cancer who presented with a novel, biphasic histologic morphology with one component consisting of poorly differentiated adenocarcinoma and the other component consisting of chondromyxoid matrix with adenocarcinoma transition to, between the two components without a spindle cell component...
2023: Frontiers in Oncology
https://read.qxmd.com/read/36707876/transcriptomic-alterations-underlying-metaplasia-into-specific-metaplastic-components-in-metaplastic-breast-carcinoma
#3
JOURNAL ARTICLE
Huang-Chun Lien, Chia-Lang Hsu, Yen-Shen Lu, Tom Wei-Wu Chen, I-Chun Chen, Yu-Chia Li, Chiun-Sheng Huang, Ann-Lii Cheng, Ching-Hung Lin
BACKGROUND: Metaplastic breast carcinoma (MpBC) typically consists of carcinoma of no special type (NST) with various metaplastic components. Although previous transcriptomic and proteomic studies have reported subtype-related heterogeneity, the intracase transcriptomic alterations between metaplastic components and paired NST components, which are critical for understanding the pathogenesis underlying the metaplastic processes, remain unclear. METHODS: Fifty-nine NST components and paired metaplastic components (spindle carcinomatous [SPS], matrix-producing, rhabdoid [RHA], and squamous carcinomatous [SQC] components) were microdissected from specimens obtained from 27 patients with MpBC for gene expression profiling using the NanoString Breast Cancer 360 Panel on a NanoString nCounter FLEX platform...
January 27, 2023: Breast Cancer Research: BCR
https://read.qxmd.com/read/36261938/benign-osseous-metaplasia-of-the-breast-infiltrated-by-invasive-pleomorphic-lobular-carcinoma-a-case-report
#4
Hessa Aljhdali, Salena Bains, Vijaya Ganesh, Shekhar Kaneri, Abeer M Shaaban
INTRODUCTION AND IMPORTANCE: Benign osseous metaplasia (BOM) is a rare entity, with only few cases reported in the breast. Here we present an unusual case of pleomorphic lobular carcinoma of the breast infiltrating BOM, discuss potential mimics and review the literature. CASE PRESENTATION: An 86 year-old female presented with right breast lump for two weeks. Clinical examination revealed a palpable mass, associated with skin tethering and nipple inversion. Mammography and ultrasound showed a densely calcified lesion associated with parenchymal distortion...
October 2022: International Journal of Surgery Case Reports
https://read.qxmd.com/read/34607549/spindle-cell-metaplastic-breast-carcinoma
#5
Vithya Sanmugasiva, Marlina Tanty Ramli Hamid, Farhana Fadzli, Nazimah Ab Mumin, Kartini Rahmat
INTRODUCTION: Metaplastic breast carcinoma is an uncommon malignancy that constitutes < 5% of all breast cancers. There are 5 subtypes which are spindle cell, squamous cell, carcinosarcoma, matrix-producing and metaplastic with osteoclastic giant cells. Spindle cell carcinoma represents approximately <0.3% of invasive breast carcinomas. It is typically a triple-negative cancer with distinct pathological characteristics, but relatively a non-conclusive on imaging findings. CASE REPORT: An elderly lady presented with an enlarging painful left breast lump for one year...
2022: Current medical imaging
https://read.qxmd.com/read/34294707/poor-response-to-neoadjuvant-chemotherapy-in-metaplastic-breast-carcinoma
#6
JOURNAL ARTICLE
Willard Wong, Edi Brogi, Jorge S Reis-Filho, George Plitas, Mark Robson, Larry Norton, Monica Morrow, Hannah Y Wen
Metaplastic breast carcinoma (MpBC) is a rare special histologic subtype of breast carcinoma characterized by the presence of squamous and/or mesenchymal differentiation. Most MpBCs are of triple-negative phenotype and neoadjuvant chemotherapy (NAC) is frequently utilized in patients with MpBC. The aim of this study was to evaluate response to NAC in a retrospective cohort of MpBCs. We identified 44 patients with MpBC treated with NAC at our center between 2002 and 2018. Median age was 48 years, 86% were clinical stage II-III, and 36% were clinically node-positive...
July 22, 2021: NPJ Breast Cancer
https://read.qxmd.com/read/33942253/clinicopathologic-and-genetic-features-of-metaplastic-breast-cancer-with-osseous-differentiation-a-series-of-6-cases
#7
JOURNAL ARTICLE
Xue Chao, Wanlin Tan, Julia Y Tsang, Gary M Tse, Jintao Hu, Ping Li, Jinghui Hou, Mei Li, Jiehua He, Peng Sun
AIMS: Metaplastic breast cancer (MBC) comprises a heterogeneous group of tumors, of which MBC with osseous differentiation (MBC-OD) is extremely rare that only few cases have been reported. This study aimed to present the clinicopathologic and molecular features of MBC-OD. METHODS: We collected 6 cases of MBC-OD from five different centers and described its clinicopathologic and molecular characteristics based on the next-generation sequencing. Another 11 cases from the literature were also reviewed to better characterize the tumor...
September 2021: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/31010590/fibrillin-1-a-novel-tgf-beta-induced-factor-is-preferentially-expressed-in-metaplastic-carcinoma-with-spindle-sarcomatous-metaplasia
#8
JOURNAL ARTICLE
Huang-Chun Lien, Yi-Hsuan Lee, Yu-Lin Juang, Yueh-Tong Lu
TGF-β induces epithelial-mesenchymal transition (EMT), which is involved in tumour progression. This study aims to identify and characterise novel factors potentially related to TGF-β-mediated tumour aggression in breast cancer. We treated the human mammary epithelial cell line MCF10A with TGF-β and observed TGF-β-dependent upregulation of FBN1, involving demethylation of CpG sites, in MCF10A cells undergoing EMT. The biological importance of fibrillin-1, encoded by FBN1, was evaluated through immunohistochemistry on 225 breast cancer specimens of various subtypes...
June 2019: Pathology
https://read.qxmd.com/read/30723293/metaplastic-breast-carcinoma-a-clinical-pathologic-study-of-97-cases-with-subset-analysis-of-response-to-neoadjuvant-chemotherapy
#9
JOURNAL ARTICLE
Min Han, Arsalan Salamat, Li Zhu, Huina Zhang, Beth Z Clark, David J Dabbs, Gloria J Carter, Adam M Brufsky, Rachel C Jankowitz, Shannon L Puhalla, Ronald R Johnson, Atilla Soran, Jennifer G Steiman, Priscilla F McAuliffe, Emilia J Diego, Rohit Bhargava
Metaplastic breast carcinoma is a rare heterogeneous category of breast cancer, often associated with a poor prognosis. Clinical-pathologic studies with respect to varied morphologic subtypes are lacking. There is also a dearth of studies assessing the response of metaplastic breast carcinoma to neoadjuvant chemotherapy. Cases of metaplastic breast carcinoma diagnosed between 2007 and 2017 were identified. Various clinical-pathologic variables were tested for association with survival. Patients who underwent neoadjuvant chemotherapy were assessed for pathologic response...
June 2019: Modern Pathology
https://read.qxmd.com/read/30428388/microglandular-adenosis-is-an-advanced-precursor-breast-lesion-with-evidence-of-molecular-progression-to-matrix-producing-metaplastic-carcinoma
#10
JOURNAL ARTICLE
Christopher J Schwartz, Igor Dolgalev, Esther Yoon, Iman Osman, Adriana Heguy, Eleazar C Vega-Saenz de Miera, Diana Nimeh, George Jour, Farbod Darvishian
Microglandular adenosis (MGA) is a rare breast lesion reported to be associated with invasive carcinoma in up to 20% to 30% of cases and has been proposed as a nonobligate precursor to basal-like breast cancers. We identified a case of matrix-producing metaplastic carcinoma with morphologic and immunohistochemical evidence of progression from MGA to atypical MGA, carcinoma in situ, and invasive carcinoma. We performed whole-exome sequencing of each component (MGA, atypical MGA, carcinoma in situ, and cancer) to characterize the mutational landscape of these foci...
March 2019: Human Pathology
https://read.qxmd.com/read/29946183/genomic-profiling-of-metaplastic-breast-carcinomas-reveals-genetic-heterogeneity-and-relationship-to-ductal-carcinoma
#11
JOURNAL ARTICLE
Gregor Krings, Yunn-Yi Chen
Metaplastic breast carcinomas comprise a histologically heterogenous group of tumors. Although most are triple (estrogen/progesterone receptor, HER2) negative, these rare tumors are clinicopathologically distinct from other triple negative carcinomas and may be aggressive with worse chemotherapy responses. On the other hand, metaplastic carcinomas are histologically diverse, which is reflected in gene expression differences among subtypes. Whether metaplastic carcinomas are genetically distinct from other triple negative cancers and whether genetic differences underlie histologic subtypes remains poorly understood...
November 2018: Modern Pathology
https://read.qxmd.com/read/29483966/differential-expression-and-clinical-significance-of-epithelial-mesenchymal-transition-markers-among-different-histological-types-of-triple-negative-breast-cancer
#12
JOURNAL ARTICLE
Shuling Zhou, Xiangjie Sun, Lin Yu, Ruoji Zhou, Anqi Li, Ming Li, Wentao Yang
Background: Triple-negative breast cancer (TNBC) is a heterogeneous disease closely associated with epithelial-to-mesenchymal transition (EMT). This study aimed to investigate the role of EMT in metaplastic carcinoma. Methods: E-cadherin, Slug, Twist and Vimentin levels were detected by immunohistochemistry in 167 TNBC tumors, including 145 invasive carcinomas of no special type (ICONSTs), 14 spindle cell carcinomas (SpCCs) and 8 matrix-producing carcinomas (MPCs). Results: Nuclear Slug and Twist were more frequently detected in SpCC and MPC tumors than that in ICONST tumors (p<0...
2018: Journal of Cancer
https://read.qxmd.com/read/28626128/a-case-of-matrix-producing-carcinoma-of-the-breast
#13
JOURNAL ARTICLE
Yuzuru Inoue, Fumi Joden, Kei Yabuki, Nagahiro Sato, Noritaka Minagawa, Takefumi Katsuki, Norihiro Sato, Takahisa Nagata, Kazunori Shibao, Atsuji Matsuyama, Takatoshi Aoki, Keiji Hirata
A 61-year-old woman was referred to our hospital because of a right breast mass. A 19 mm hard mass was palpable in the A area of the right breast. A contrast-enhanced MRI showed rim enhancement at the peripheral region of the tumor, which was thought to represent the carcinoma component mainly at the periphery and the matrix component inside the tumor. A low density mass with rim enhancement at the peripheral region was observed in a contrast-enhanced CT, the same as in the MRI. Neither axillary lymph node metastasis nor distant metastasis was observed...
2017: Journal of UOEH
https://read.qxmd.com/read/27568101/metaplastic-breast-cancer-molecular-typing-and-identification-of-potential-targeted-therapies-at-a-single-institution
#14
JOURNAL ARTICLE
Jessica Edenfield, Christine Schammel, Justin Collins, David Schammel, W Jeff Edenfield
INTRODUCTION: Metaplastic breast carcinoma (MBC) is a rare and aggressive histologic subtype of breast cancer comprising approximately 0.5% to 5.0% of all invasive breast cancers with a poor prognosis and limited therapeutic options. PATIENTS AND METHODS: We investigated MBC at our institution to evaluate outcomes and investigate the molecular profile of our cohort to determine the presence of mutations for which there are targeted therapies. RESULTS: We found our cohort to consist mainly of the matrix-producing variant (72%) with 48% having the stereotypical estrogen receptor-negative/progesterone receptor-negative/human epidermal growth factor receptor-2-negative phenotype...
February 2017: Clinical Breast Cancer
https://read.qxmd.com/read/25731381/-a-case-report-of-matrix-producing-carcinoma-of-the-breast
#15
JOURNAL ARTICLE
Kanae Nitta, Chiyomi Egawa, Tomo Ishida, Yasufumi Sato, Yoshihiro Morimoto, Hiroki Kusama, Tadayoshi Hashimoto, Katsunori Matsushita, Kei Kimura, Yoshiteru Katsura, Yoshinori Kagawa, Masatsugu Okishiro, Atsushi Takeno, Hideki Sakisaka, Shin Nakahira, Hirokazu Taniguchi, Yutaka Takeda, Takeshi Kato, Kazuko Oku, Takayoshi Goto, Teruaki Nagano, Shinichi Nakatsuka, Shigeyuki Tamura, Yuichi Takatsuka
A 43 -year-old woman with a palpable mass in the right breast consulted a neighborhood doctor. She was diagnosed with right breast cancer after core needle biopsy, and she was referred to our hospital. Mammography revealed an indistinct mass with calcification in the lower outer quadrant of the right breast. Ultrasonography revealed a hypoechoic mass with a high echo spot. Magnetic resonance imaging (MRI) revealed a high intensity tumor with peripheral enhancement. The patient underwent mastectomy with sentinel lymph node(SN) biopsy and axillary lymph node dissection...
November 2014: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/24246799/metaplastic-carcinoma-of-the-breast-with-chondroid-differentiation-matrix-producing-carcinoma-study-of-the-diagnostic-cost-effectiveness-of-fine-needle-aspiration-biopsy-and-needle-core-biopsy
#16
JOURNAL ARTICLE
M T Soler Monsó, I Català, M Terricabras, A Petit, F Climent, L Pérez-Casanovas, A Gumà, I Morilla
UNLABELLED: Metaplastic carcinoma with chondroid differentiation (MMPC) is a subtype of breast metaplastic carcinoma with mesenchymal differentiation. Although fine-needle aspiration (FNAB) and core-needle biopsy (CNB) are commonly used for the diagnosis of breast cancer, not enough studies proving the diagnostic cost-effectiveness of these techniques for the identification of MMPC have been published so far. The aim of this study was to investigate the concordance between the presurgical diagnosis using FNAB/CNB and the definitive diagnosis in the surgical specimen in pure MMPC...
2014: Acta Cytologica
https://read.qxmd.com/read/23741218/matrix-producing-carcinoma-of-the-breast-a-case-report
#17
Lorenzo Rossi, Carlo Paglicci, Giuliana Caprio, Simona Barberi, Ersilia Ranieri, Serena Zancla, Mario Rengo, Paola Pagni
Matrix-producing breast cancer (MPC) is a subtype of metaplastic carcinoma of the breast. It is a very rare tumor, which constitutes less than 1% of all malignant mammary tumors. The origin of this tumor is still unclear: there are molecular studies that suggest an origin from myoepithelial cells, whereas other studies underline the neoplastic transformation of a multipotent stem cell. Even the differential diagnosis of MPC and other breast neoplasms (phyllodes tumors and real sarcomas of the breast) is not always easy...
May 2013: Case Reports in Oncology
https://read.qxmd.com/read/23084962/do-primary-mammary-osteosarcoma-and-chondrosarcoma-exist-a-review-of-a-large-multi-institutional-series-of-malignant-matrix-producing-breast-tumours
#18
MULTICENTER STUDY
Emad A Rakha, Puay Hoon Tan, Abeer Shaaban, Gary M Tse, Fina Climent Esteller, Carolien H M van Deurzen, Dave Purnell, Anne Stotter, Timothy Chan, Rin Yamaguchi, David Dodwell, Agnes Jager, Maria Teresa Soler, Enaam Juneinah, M L Plaza, Zsolt Hodi, Tom McCulloch, Andrew H S Lee, Ian O Ellis
UNLABELLED: The existing literature describing the clinicopathological features and behaviour of matrix-producing (MP) malignant breast tumours presents conflicting results. As a consequence it remains uncertain whether these tumours should be treated as sarcoma and managed by a specialist sarcoma team or treated using the same principles as conventional ductal carcinoma, a dilemma that prompted this study. Improved understanding of the clinicopathological characteristics of primary mammary MP-sarcomas, namely osteosarcoma and chondrosarcoma, is required...
February 2013: Breast: Official Journal of the European Society of Mastology
https://read.qxmd.com/read/22431179/immunohistochemical-study-of-metaplastic-carcinoma-and-central-acellular-carcinoma-of-the-breast-central-acellular-carcinoma-is-related-to-metaplastic-carcinoma
#19
JOURNAL ARTICLE
Rin Yamaguchi, Maki Tanaka, Keiko Kondo, Toshiro Yokoyama, Ichiro Maeda, Shin-Ichi Tsuchiya, Miki Yamaguchi, Ryuji Takahashi, Yutaka Ogata, Hideyuki Abe, Jun Akiba, Osamu Nakashima, Masayoshi Kage, Hirohisa Yano
Metaplastic breast cancers (MBCs) [spindle cell carcinoma (SpCC), squamous cell carcinoma (SCC), and matrix-producing carcinoma (MPC)] and invasive carcinomas with central acellular zones (CACs) were analyzed with respect to biological potential by immunohistochemical analyses. Specimens from 40 patients [20 with MBCs (7 with SCC, 6 with SpCC, 5 with MPC, and 2 with mixed type)] and 20 with CACs were analyzed using antibodies to cytokeratin (CK) 8, 5/6, 14, AE1/AE3, 34αE12, involucrin, c-kit, vimentin (VIM), alpha-smooth muscle actin, p63, epidermal growth factor receptor, epithelial cell adhesion molecule, and estrogen receptor (ER)/progesterone receptor (PR)/HER2...
December 2012: Medical Molecular Morphology
https://read.qxmd.com/read/20153509/clinicopathologic-study-of-53-metaplastic-breast-carcinomas-their-elements-and-prognostic-implications
#20
JOURNAL ARTICLE
Rin Yamaguchi, Rie Horii, Ichiro Maeda, Sachie Suga, Masujiro Makita, Takuji Iwase, Masahiko Oguchi, Yoshinori Ito, Futoshi Akiyama
Metaplastic carcinoma of the breast is a relatively rare cancer and includes various histologic types. In this cancer, metaplastic elements are heterogeneous and sometimes mixed. We investigated, by histopathologic means, these elements and clinical implications that could indicate the clinical course (including the prognosis). Fifty-three metaplastic breast carcinoma cases and their prognoses were investigated by initially examining the presence or absence of spindle-cell elements, and then the presence or absence of other elements...
May 2010: Human Pathology
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