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Matrix producing metaplastic breast cancer

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https://www.readbyqxmd.com/read/27568101/metaplastic-breast-cancer-molecular-typing-and-identification-of-potential-targeted-therapies-at-a-single-institution
#1
Jessica Edenfield, Christine Schammel, Justin Collins, David Schammel, W Jeff Edenfield
INTRODUCTION: Metaplastic breast carcinoma (MBC) is a rare and aggressive histologic subtype of breast cancer comprising approximately 0.5% to 5.0% of all invasive breast cancers with a poor prognosis and limited therapeutic options. PATIENTS AND METHODS: We investigated MBC at our institution to evaluate outcomes and investigate the molecular profile of our cohort to determine the presence of mutations for which there are targeted therapies. RESULTS: We found our cohort to consist mainly of the matrix-producing variant (72%) with 48% having the stereotypical estrogen receptor-negative/progesterone receptor-negative/human epidermal growth factor receptor-2-negative phenotype...
July 25, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/25731381/-a-case-report-of-matrix-producing-carcinoma-of-the-breast
#2
Kanae Nitta, Chiyomi Egawa, Tomo Ishida, Yasufumi Sato, Yoshihiro Morimoto, Hiroki Kusama, Tadayoshi Hashimoto, Katsunori Matsushita, Kei Kimura, Yoshiteru Katsura, Yoshinori Kagawa, Masatsugu Okishiro, Atsushi Takeno, Hideki Sakisaka, Shin Nakahira, Hirokazu Taniguchi, Yutaka Takeda, Takeshi Kato, Kazuko Oku, Takayoshi Goto, Teruaki Nagano, Shinichi Nakatsuka, Shigeyuki Tamura, Yuichi Takatsuka
A 43 -year-old woman with a palpable mass in the right breast consulted a neighborhood doctor. She was diagnosed with right breast cancer after core needle biopsy, and she was referred to our hospital. Mammography revealed an indistinct mass with calcification in the lower outer quadrant of the right breast. Ultrasonography revealed a hypoechoic mass with a high echo spot. Magnetic resonance imaging (MRI) revealed a high intensity tumor with peripheral enhancement. The patient underwent mastectomy with sentinel lymph node(SN) biopsy and axillary lymph node dissection...
November 2014: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/24246799/metaplastic-carcinoma-of-the-breast-with-chondroid-differentiation-matrix-producing-carcinoma-study-of-the-diagnostic-cost-effectiveness-of-fine-needle-aspiration-biopsy-and-needle-core-biopsy
#3
M T Soler Monsó, I Català, M Terricabras, A Petit, F Climent, L Pérez-Casanovas, A Gumà, I Morilla
UNLABELLED: Metaplastic carcinoma with chondroid differentiation (MMPC) is a subtype of breast metaplastic carcinoma with mesenchymal differentiation. Although fine-needle aspiration (FNAB) and core-needle biopsy (CNB) are commonly used for the diagnosis of breast cancer, not enough studies proving the diagnostic cost-effectiveness of these techniques for the identification of MMPC have been published so far. The aim of this study was to investigate the concordance between the presurgical diagnosis using FNAB/CNB and the definitive diagnosis in the surgical specimen in pure MMPC...
2014: Acta Cytologica
https://www.readbyqxmd.com/read/23741218/matrix-producing-carcinoma-of-the-breast-a-case-report
#4
Lorenzo Rossi, Carlo Paglicci, Giuliana Caprio, Simona Barberi, Ersilia Ranieri, Serena Zancla, Mario Rengo, Paola Pagni
Matrix-producing breast cancer (MPC) is a subtype of metaplastic carcinoma of the breast. It is a very rare tumor, which constitutes less than 1% of all malignant mammary tumors. The origin of this tumor is still unclear: there are molecular studies that suggest an origin from myoepithelial cells, whereas other studies underline the neoplastic transformation of a multipotent stem cell. Even the differential diagnosis of MPC and other breast neoplasms (phyllodes tumors and real sarcomas of the breast) is not always easy...
May 2013: Case Reports in Oncology
https://www.readbyqxmd.com/read/23084962/do-primary-mammary-osteosarcoma-and-chondrosarcoma-exist-a-review-of-a-large-multi-institutional-series-of-malignant-matrix-producing-breast-tumours
#5
MULTICENTER STUDY
Emad A Rakha, Puay Hoon Tan, Abeer Shaaban, Gary M Tse, Fina Climent Esteller, Carolien H M van Deurzen, Dave Purnell, Anne Stotter, Timothy Chan, Rin Yamaguchi, David Dodwell, Agnes Jager, Maria Teresa Soler, Enaam Juneinah, M L Plaza, Zsolt Hodi, Tom McCulloch, Andrew H S Lee, Ian O Ellis
UNLABELLED: The existing literature describing the clinicopathological features and behaviour of matrix-producing (MP) malignant breast tumours presents conflicting results. As a consequence it remains uncertain whether these tumours should be treated as sarcoma and managed by a specialist sarcoma team or treated using the same principles as conventional ductal carcinoma, a dilemma that prompted this study. Improved understanding of the clinicopathological characteristics of primary mammary MP-sarcomas, namely osteosarcoma and chondrosarcoma, is required...
February 2013: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/22431179/immunohistochemical-study-of-metaplastic-carcinoma-and-central-acellular-carcinoma-of-the-breast-central-acellular-carcinoma-is-related-to-metaplastic-carcinoma
#6
Rin Yamaguchi, Maki Tanaka, Keiko Kondo, Toshiro Yokoyama, Ichiro Maeda, Shin-Ichi Tsuchiya, Miki Yamaguchi, Ryuji Takahashi, Yutaka Ogata, Hideyuki Abe, Jun Akiba, Osamu Nakashima, Masayoshi Kage, Hirohisa Yano
Metaplastic breast cancers (MBCs) [spindle cell carcinoma (SpCC), squamous cell carcinoma (SCC), and matrix-producing carcinoma (MPC)] and invasive carcinomas with central acellular zones (CACs) were analyzed with respect to biological potential by immunohistochemical analyses. Specimens from 40 patients [20 with MBCs (7 with SCC, 6 with SpCC, 5 with MPC, and 2 with mixed type)] and 20 with CACs were analyzed using antibodies to cytokeratin (CK) 8, 5/6, 14, AE1/AE3, 34αE12, involucrin, c-kit, vimentin (VIM), alpha-smooth muscle actin, p63, epidermal growth factor receptor, epithelial cell adhesion molecule, and estrogen receptor (ER)/progesterone receptor (PR)/HER2...
December 2012: Medical Molecular Morphology
https://www.readbyqxmd.com/read/20153509/clinicopathologic-study-of-53-metaplastic-breast-carcinomas-their-elements-and-prognostic-implications
#7
Rin Yamaguchi, Rie Horii, Ichiro Maeda, Sachie Suga, Masujiro Makita, Takuji Iwase, Masahiko Oguchi, Yoshinori Ito, Futoshi Akiyama
Metaplastic carcinoma of the breast is a relatively rare cancer and includes various histologic types. In this cancer, metaplastic elements are heterogeneous and sometimes mixed. We investigated, by histopathologic means, these elements and clinical implications that could indicate the clinical course (including the prognosis). Fifty-three metaplastic breast carcinoma cases and their prognoses were investigated by initially examining the presence or absence of spindle-cell elements, and then the presence or absence of other elements...
May 2010: Human Pathology
https://www.readbyqxmd.com/read/18622387/cartilaginous-features-in-matrix-producing-carcinoma-of-the-breast-four-cases-report-with-histochemical-and-immunohistochemical-analysis-of-matrix-molecules
#8
Kimihide Kusafuka, Koji Muramatsu, Masako Kasami, Ken Kuriki, Kumiko Hirobe, Isamu Hayashi, Hideto Watanabe, Yuji Hiraki, Chisa Shukunami, Toru Mochizuki, Toru Kameya
Matrix-producing carcinoma of the breast is a well-established entity in the group of metaplastic carcinoma, which is histologically characterized by myxochondroid matrix formation and is extremely rare. We describe here four additional cases of matrix-producing carcinoma of the breast. All cases of matrix-producing carcinoma show nest-like, sheet-like, and cord-like growth of tumor cells with cellular atypia, in addition to scattered cancer cells within myxoid or myxohyalinous stroma. Three of four cases showed an acellular or oligocellular matrix-rich zone in the center of the tumor...
October 2008: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/18559079/a-case-of-matrix-producing-carcinoma-of-the-breast
#9
Toshiyuki Hirose, Junko Honda, Yoshimi Bando, Mitsunori Sasa, Yukiko Hirose, Taeko Nagao, Akira Tangoku
BACKGROUND: Matrix-producing carcinoma (MPC) of the breast is one variant type of metaplastic carcinoma. The cellular origin of MPC remains unclear. It has been suggested the tumor cells in MPC have the combined characteristics of both epithelial cells and mesenchymal cells. Several reports suggested that the tumor cells in MPC might originate from the myoepithelial cells, but others suggested the origin was basal-like cells. CASE PRESENTATION: The patient was a 42-year-old Japanese female...
2008: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/17998680/role-of-adjuvant-radiotherapy-in-metaplastic-matrix-producing-breast-cancer-a-case-study-with-review-of-literature
#10
Piyush Kumar, Tanu Agarwal, Narendra Krishnani, Shalini Singh, Niloy R Datta
A rare and unique variant of breast cancer--metaplastic matrix producing carcinoma, is presented. Surgery has been the mainstay of treatment. The role of adjuvant postoperative radiotherapy, as has been used in this patient, has been reviewed.
April 2006: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/16647355/metaplastic-breast-cancer-clinical-significance
#11
COMPARATIVE STUDY
J David Beatty, Mary Atwood, Ronald Tickman, Maureen Reiner
BACKGROUND: Metaplastic breast carcinoma (MBC) is a rare poorly differentiated breast cancer characterized by coexistence of ductal carcinoma with areas of matrix producing, spindle-cell, sarcomatous, or squamous differentiation; ER/PR/HER2 negativity; and a reputation for poor outcome. METHODS: The Swedish Cancer Institute prospective breast cancer database (> 6500 patients; 1990-2005) has 24 MBC cases that were compared with typical breast cancer cases matched for age, date of diagnosis, stage, and ER/PR/HER2 status...
May 2006: American Journal of Surgery
https://www.readbyqxmd.com/read/10928181/metaplastic-carcinoma-of-the-breast-analysis-of-eight-asian-patients-with-special-emphasis-on-two-unusual-cases-presenting-with-inflammatory-type-breast-cancer
#12
REVIEW
S H Kuo, C L Chen, C S Huang, A L Cheng
Metaplastic carcinoma of the breast is a rare form of breast cancer and has an uncertain prognostic significance. Cases from Asian countries have never been reported in the English literature. Between 1983 and 1998, we encountered 8 cases in our institution. There were 7 women and one man with a median age of 52.5 (37-73) years. Pathologic diagnosis included three poorly-differentiated adenosquamous carcinomas, two adenocarcinomas with spindle cell metaplasia, two matrix-producing carcinomas and one carcinosarcoma...
May 2000: Anticancer Research
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