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https://www.readbyqxmd.com/read/29691817/bioceramics-for-osteochondral-tissue-engineering-and-regeneration
#1
Sandra Pina, Rita Rebelo, Vitor Manuel Correlo, J Miguel Oliveira, Rui L Reis
Considerable advances in tissue engineering and regeneration have been accomplished over the last decade. Bioceramics have been developed to repair, reconstruct, and substitute diseased parts of the body and to promote tissue healing as an alternative to metallic implants. Applications embrace hip, knee, and ligament repair and replacement, maxillofacial reconstruction and augmentation, spinal fusion, bone filler, and repair of periodontal diseases. Bioceramics are well-known for their superior wear resistance, high stiffness, resistance to oxidation, and low coefficient of friction...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29689396/in-situ-decompression-to-spinal-cord-during-anterior-controllable-antedisplacement-fusion-treating-degenerative-kyphosis-with-stenosis-surgical-outcomes-and-analysis-of-c5-nerve-palsy-based-on-49-patients
#2
Haisong Yang, Jingchuan Sun, Jiangang Shi, Yong Yang, Yongfei Guo, Bing Zheng, Yuan Wang
OBJECTIVE: To observe outcomes of anterior controllable antedisplacement fusion (ACAF) in the treatment for degenerative kyphosis with stenosis (DKS) and analyze the probability of C5 nerve palsy. METHODS: In the period from 2016 to 2017, a consecutive cohort of adults with DKS underwent ACAF. All these patients were performed cervical plain films, CT and MRI. The operation duration, blood loss and hospital stay was estimated. Radiologic assessment included kyphotic correction, decompression width and spinal canal area...
April 21, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29689393/peak-timing-for-complications-following-adult-spinal-deformity-surgery
#3
Alan H Daniels, Shay Bess, Breton Line, Adam E M Eltorai, Daniel B C Reid, Virginie Lafage, Behrooz A Akbarnia, Christopher P Ames, Oheneba Boachie-Adjei, Douglas C Burton, Vedat Deviren, Han Jo Kim, Robert A Hart, Khaled M Kebaish, Eric O Klineberg, Munish Gupta, Gregory M Mundis, Richard A Hostin, Michael O'Brien, Frank J Schwab, Christopher I Shaffrey, Justin S Smith
BACKGROUND: Overall complication rates for adult spinal deformity (ASD) surgery have been reported, however little data exists on the peak timing associated with specific complications. This study quantifies the peak timing for multiple complication types in an ASD cohort at minimum 2-year follow up. METHODS: Multi-center, prospective analysis of all complications following ASD surgery in a consecutively enrolled cohort was performed. Inclusion criteria were ASD, age ≥ 18 years, spinal fusion ≥ 4 levels, and minimum 2-year follow-up...
April 21, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29689005/perioperative-complications-after-surgery-for-thoracic-ossification-of-posterior-longitudinal-ligament-nationwide-multicenter-prospective-study
#4
Shiro Imagama, Kei Ando, Kazuhiro Takeuchi, Satoshi Kato, Hideki Murakami, Toshimi Aizawa, Hiroshi Ozawa, Tomohiko Hasegawa, Yukihiro Matsuyama, Masao Koda, Masashi Yamazaki, Hirotaka Chikuda, Shigeo Shindo, Yukihiro Nakagawa, Atsushi Kimura, Katsushi Takeshita, Kanichiro Wada, Hiroyuki Katoh, Masahiko Watanabe, Kei Yamada, Takeo Furuya, Takashi Tsuji, Shunsuke Fujibayashi, Kanji Mori, Yoshiharu Kawaguchi, Kota Watanabe, Morio Matsumoto, Toshitaka Yoshii, Atsushi Okawa
STUDY DESIGN: Prospective, multicenter, nationwide study OBJECTIVE.: To investigate perioperative complications and risk factors in surgery for thoracic ossification of the posterior longitudinal ligament (T-OPLL) using data from the registry of the Japanese Multicenter Research Organization for Ossification of the Spinal Ligament. SUMMARY OF BACKGROUND DATA: There is no prospective multicenter study of surgical complications and risk factors for T-OPLL, and previous multicenter retrospective studies have lacked details...
April 23, 2018: Spine
https://www.readbyqxmd.com/read/29689004/assessment-of-proximal-junctional-kyphosis-and-shoulder-balance-with-proximal-screws-vs-hooks-in-posterior-spinal-fusion-for-adolescent-idiopathic-scoliosis
#5
Joshua M Pahys, Andrew C Vivas, Amer F Samdani, Gregory Cunn, Randal R Betz, Peter O Newton, Patrick J Cahill
STUDY DESIGN: A retrospective review of a prospectively collected multicenter database OBJECTIVE.: To assess the effect of proximal hooks vs. screws on proximal junctional kyphosis (PJK) as well as shoulder balance in otherwise all pedicle screw (>80%) posterior spinal fusion (PSF) constructs in adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA: Less rigid forms of fixation at the top of constructs in degenerative lumbar PSF have been postulated to decrease the risk of PJK...
April 23, 2018: Spine
https://www.readbyqxmd.com/read/29688555/a-pilot-study-on-posterior-polyethylene-tethers-to-prevent-proximal-junctional-kyphosis-after-multilevel-spinal-instrumentation-for-adult-spinal-deformity
#6
Thomas J Buell, Avery L Buchholz, John C Quinn, Shay Bess, Breton G Line, Christopher P Ames, Frank J Schwab, Virginie Lafage, Christopher I Shaffrey, Justin S Smith
BACKGROUND: Proximal junctional kyphosis (PJK) is a common problem after multilevel spine instrumentation. OBJECTIVE: To determine if junctional tethers reduce PJK after multilevel instrumented surgery for adult spinal deformity (ASD). METHODS: ASD patients who underwent posterior instrumented fusion were divided into 3 groups: no tether (NT), polyethylene tether-only (TO; tied securely through the spinous processes of the uppermost instrumented vertebra [UIV] + 1 and UIV-1), and tether with crosslink (TC; passed through the spinous process of UIV+1 and tied to a crosslink between UIV-1 and UIV-2)...
April 24, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29687593/incorporating-si-3-n-4-into-peek-to-produce-antibacterial-osteocondutive-and-radiolucent-spinal-implants
#7
Giuseppe Pezzotti, Elia Marin, Tetsuya Adachi, Federica Lerussi, Alfredo Rondinella, Francesco Boschetto, Wenliang Zhu, Takashi Kitajima, Kosuke Inada, Bryan J McEntire, Ryan M Bock, B Sonny Bal, Osam Mazda
Polyetheretherketone (PEEK) is a popular polymeric biomaterial which is primarily used as an intervertebral spacer in spinal fusion surgery; but it is developed for trauma, prosthodontics, maxillofacial, and cranial implants. It has the purported advantages of an elastic modulus which is similar to native bone and it can be easily formed into custom 3D shapes. Nevertheless, PEEK's disadvantages include its poor antibacterial resistance, lack of bioactivity, and radiographic transparency. This study presents a simple approach to correcting these three shortcomings while preserving the base polymer's biocompatibility, chemical stability, and elastic modulus...
April 24, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29686917/a-recurrent-cervical-neurenteric-cyst-treated-anteriorly-safe-gross-total-excision-facilitated-by-prophylactic-unilateral-vertebral-artery-exposure-microdissection-and-spinal-cord-monitoring-a-case-report-and-technical-note
#8
Kazunobu Kida, Toshikazu Tani, Tateo Kawazoe, Makoto Hiroi
This study reports on a 67-year-old woman with partial Brown-Séquard syndrome due to a recurrent cervical neurenteric cyst at C3 to C4. The myelopathic symptoms reappeared 22 years after a previous shunting operation performed posteriorly with a silicone tube connecting the intradural cervical cyst cavity to the subarachnoid space. We have now succeeded in removing the cyst nearly completely with the anterior approach. The surgical procedure consisted of right vertebral artery exposure at C3 and C4 and a subtotal corpectomy of C3 followed by microdissection of the cyst, duraplasty, and iliac strut graft fusion...
2018: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29684943/the-diagnostic-implications-of-two-cases-of-known-rheumatoid-arthritis-from-the-cal-milano-cemetery-skeletal-collection
#9
Lucie Biehler-Gomez, Cristina Cattaneo
Rheumatoid arthritis (RA) is the most common erosive arthropathy and is of particular interest to forensic sciences. However, its diagnosis on bones remains challenging. We examined two skeletons from the CAL Milano Cemetery Skeletal Collection diagnosed with the pathology during life, to test the validity of the diagnostic criteria on bones. The first showed typical lesions of RA described in the literature. The second exhibited secondary osteoarthrosis, suggesting long-standing RA. A differential diagnosis including all four seronegative spondyloarthropathies, erosive osteoarthritis, gout and neuropathic arthropathy was also considered...
April 23, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29682062/dural-ectasia-and-cauda-equina-syndrome-a-rare-complication-of-long-standing-fusion
#10
Vrushali D Bachhav, Sumeet G Dua, Miral D Jhaveri
The clinicoradiological combination of cauda equina syndrome (CES) and dural ectasia is rare and has been described in a few of patients with ankylosing spondylitis (AS). Simultaneous occurrence of these entities in the absence of AS and in patients with long-standing spinal fusion is extremely rare. We present a case of dural ectasia and CES occurring as a long-term complication of instrumented spinal fusion and discuss the pathogenesis, imaging findings, and management options of this elusive disease process...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29682034/bone-turnover-in-vertebral-fractures-does-it-effect-the-decision-of-surgery
#11
Zeki Serdar Ataizi, Hasan Emre Aydin, Evin Kocatürk, Ahmet Çerezci, İbrahim Özkan Alatas
Background and Aim: Instrumentation is commonly used in spinal surgery to stabilize the fracture. In the present study, we aimed to compare the early and late changes seen in bone production and degradation products in patients with traumatic spinal fracture who had been treated surgically or conservatively. Materials and Methods: Forty-three patients were admitted to the Neurosurgery Department with thoracolumbar or lumbar fracture in this prospective study. Patients were divided into two groups of surgically treated ( n = 23) and nonsurgically/conservatively treated ( n = 20) patients...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29681425/epidemiology-and-national-trends-in-prevalence-and-surgical-management-of-metastatic-spinal-disease
#12
Samantha R Horn, Ekamjeet S Dhillon, Gregory W Poorman, Jared C Tishelman, Frank A Segreto, Cole A Bortz, John Y Moon, Omar Behery, Nicholas Shepard, Bassel G Diebo, Shaleen Vira, Peter G Passias
Surgical treatment for spinal metastasis has benefited from improvements in surgical techniques. However, the trends in treatment and outcomes for spinal metastasis surgery have not been well-established in a pediatric population. Patients <20 years old with metastatic spinal tumors undergoing spinal surgery were identified in the KID database. Trends for spinal metastases treatment and patient outcomes were analyzed using weight-adjusted ANOVAs. 333 patients were identified in the KID database. The top five primary diagnoses were metastatic brain/spinal cord tumor (19...
April 19, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29680510/srs-schwab-grade-4-osteotomy-for-congenital-thoracolumbar-kyphosis-a-minimum-of-2-years-follow-up-study
#13
Benlong Shi, Qinghua Zhao, Liang Xu, Zhen Liu, Xu Sun, Zezhang Zhu, Yong Qiu
BACKGROUND: Several osteotomy techniques including pedicle subtraction osteotomy and vertebral column resection have been employed in the correction of congenital kyphosis (CK) and satisfying outcomes have been demonstrated. However, the SRS-Schwab Grade 4 osteotomy, defined as resection of posterior elements, partial vertebral body and superior adjacent disc, is rarely reported in the treatment of CK. PURPOSE: To evaluate the efficiency and safety of SRS-Schwab Grade 4 osteotomy in CK patients, and to propose its optimal indication...
April 19, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29680509/opioids-delay-healing-of-spinal-fusion-a-rabbit-posterolateral-lumbar-fusion-model
#14
Nikhil Jain, Khaled Himed, Jeffrey M Toth, Karen C Briley, Frank M Phillips, Safdar N Khan
BACKGROUND CONTEXT: Opioid use is prevalent for management of pre- and post-operative pain in patients undergoing spinal fusion. There is evidence that opioids downregulate osteoblasts in-vitro, and one previous study found that morphine delays the maturation and remodeling of callus in a rat femur fracture model. However, the effect of opioids on healing of spinal fusion has not been investigated before. Isolating the effect of opioid exposure in humans would be limited by the numerous confounding factors that affect fusion healing...
April 19, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29680264/temporary-inhibition-of-the-plasminogen-activator-inhibits-periosteal-chondrogenesis-and-promotes-periosteal-osteogenesis-during-appendicular-bone-fracture-healing
#15
D Bravo, A M Josephson, V Bradaschia-Correa, M Z Wong, N L Yim, S S Neibart, S N Lee, J Huo, T Coughlin, M M Mizrahi, P Leucht
INTRODUCTION: Aminocaproic acid is approved as an anti-fibrinolytic for use in joint replacement and spinal fusion surgeries to limit perioperative blood loss. Previous animal studies have demonstrated a pro-osteogenic effect of aminocaproic acid in spine fusion models. Here, we tested if aminocaproic acid enhances appendicular bone healing and we sought to uncover the effect of aminocaproic acid on osteoprogenitor cells (OPCs) during bone regeneration. METHODS: We employed a well-established murine femur fracture model in adult C57BL/6J mice after receiving two peri-operative injections of aminocaproic acid...
April 19, 2018: Bone
https://www.readbyqxmd.com/read/29679726/late-presenting-dural-tear-incidence-risk-factors-and-associated-complications
#16
Wesley M Durand, J Mason DePasse, Eren O Kuris, JaeWon Yang, Alan H Daniels
BACKGROUND CONTEXT: Unrecognized and inadequately repaired intraoperative durotomies may lead to cerebrospinal fluid leak, pseudomeningocele, and other complications. Few studies have investigated durotomy that is unrecognized intraoperatively and requires additional postoperative management (hereafter, late-presenting dural tear [LPDT]), though estimates of LPDT range from 0.6 - 8.3 per 1,000 spinal surgeries. These single-center studies are based on relatively small sample sizes for an event of this rarity, all with <10 patients experiencing LPDT...
April 18, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29679126/-surgical-treatment-of-adult-spinal-deformities
#17
REVIEW
S M Krieg, P Vajkoczy, S-O Eicker, V Rohde, C Thome, M Stoffel, F Ringel, B Meyer
BACKGROUND: Adult spinal deformity (ASD) is mostly a progressive disease which usually leads to chronic pain. Due to increased prevalence in older people many patients suffer from comorbidities, which make conservative and surgical treatment even more complex. OBJECTIVE: This article provides an overview on the current conservative and surgical treatment options. MATERIAL AND METHODS: An extensive literature search was carried out via Medline plus an additional evaluation of the authors' personal experiences was performed...
April 20, 2018: Der Nervenarzt
https://www.readbyqxmd.com/read/29678703/anterior-controllable-antedisplacement-fusion-acaf-for-severe-cervical-ossification-of-the-posterior-longitudinal-ligament-comparison-with-anterior-cervical-corpectomy-with-fusion-accf
#18
Haisong Yang, Jingchuan Sun, Jiangang Shi, Guodong Shi, Yongfei Guo, Yong Yang
OBJECTIVE: Anterior cervical corpectomy and fusion (ACCF), in which a ventral constriction is resected, can decompress myelopathy and is considered the optimal treatment for ossification of the posterior longitudinal ligament (OPLL) up to now. However, its disadvantages are incomplete decompression, high surgery- and implant-related complication rates, and extremely surgical technique demanding. Our object was to introduce anterior controllable antedisplacement fusion (ACAF), a new surgical technique to treat OPLL, and compare it with ACCF...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29678698/the-effects-of-high-dose-parathyroid-hormone-pth-1-34-treatment-on-fusion-outcomes-in-a-rabbit-model-of-posterolateral-lumbar-spinal-fusion-alone-an-in-combination-with-bone-morphogenetic-protein-2-bmp-2-treatment
#19
Christina A Holmes, Wataru Ishida, Benjamin D Elder, Sheng-Fu Larry Lo, Yunchan Amy Chen, Edmond Kim, John Locke, Maritza Taylor, Timothy F Witham
No abstract text is available yet for this article.
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29672433/risk-factors-for-prolonged-postoperative-opioid-use-after-spinal-fusion-for-adolescent-idiopathic-scoliosis
#20
Scott Yang, Brian C Werner
No abstract text is available yet for this article.
April 18, 2018: Journal of Pediatric Orthopedics
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