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https://www.readbyqxmd.com/read/29333824/eosinophilic-esophagitis-and-esophageal-atresia-coincidence-or-causality
#1
Karen V Stave Salgado, Ana M Rocca
Eosinophilic esophagitis is an immune-mediated chronic disease of the esophagus characterized by symptoms related to esophageal dysfunction and tissue eosinophilia. In the endoscopy, the esophageal mucosa may appear normal or show exudates, rings, edema, furrows, and strictures. Its management is based on elimination diet, topical corticosteroids and/or esophageal dilation. Atresia is the most common congenital alteration of the esophagus; it requires surgical repair and poses potential complications, such as gastroesophageal reflux, strictures, and esophageal dysmotility...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29333061/critical-appraisal-of-rome-iv-criteria-hypersensitive-esophagus-does-belong-to-gastroesophageal-reflux-disease-spectrum
#2
REVIEW
Leonardo Frazzoni, Marzio Frazzoni, Nicola de Bortoli, Salvatore Tolone, Irene Martinucci, Lorenzo Fuccio, Vincenzo Savarino, Edoardo Savarino
The Rome IV Committee introduced a major change in the classification of functional gastrointestinal disorders, proposing a more restrictive definition of gastroesophageal reflux disease (GERD). It was suggested that hypersensitive esophagus (HE) may sit more firmly within the functional realm. It was suggested that GERD diagnosis should be based upon abnormal acid exposure time (AET) only, implying no advantage of impedance-pH over pH monitoring. Symptom association probability (SAP), symptom index (SI) and heartburn relief with proton pump inhibitor (PPI) therapy were regarded as unreliable, whereas a lack of response to PPI was considered as evidence of functional heartburn...
January 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29332596/synthesis-and-characterization-of-thiocarbohydrazones-and-their-inhibitory-potential-against-ignored-disease-leishmaniasis
#3
Nida Ghouri, Khalid Mohammed Khan, Arshia, M Iqbal Choudhary, Shahnaz Perveen
BACKGROUND: Leishmaniasis is a protozoan parasitic vector-borne disease which is endemic in 88 tropical countries. Infected sand fly is the main cause of this disease while, there are several vectors, parasites, and reservoirs involved in the transmission of this disease. Leishmania donovani, L. infantum, and L. chagasi are. common disease causing species, spread through sandflies. It is considered to be a focal disease having scattered foci. Leishmaniasis is a disease with a broad clinical spectrum...
January 14, 2018: Medicinal Chemistry
https://www.readbyqxmd.com/read/29324920/technetium-99m-dimercaptosuccinic-acid-renal-scintigraphy-can-guide-clinical-management-in-congenital-hydronephrosis
#4
Biljana Bazić-Đorović, Marija Radulović, Marija Šišić, Ljiljana Jauković, Sanja Dugonjić, Dragan Pucar, Zoran Janković, Slobodanka Beatović, Milica Janković, Zoran Krstić, Boris Ajdinović
OBJECTIVE: The purpose of this study was to evaluate damage of the kidney with technetium-99m-dimercaptosuccinic acid (99mTc-DMSA) scintigraphy in children with congenital hydronephrosis (CH) and the influence of other postnatal associated diagnoses on abnormal 99mTc-DMSA findings. SUBJECTS AND METHODS: 99mTc-DMSA scintigraphy in 54 children (17 girls and 37 boys), aged from 2 months to 5 years (median 11 months) with 66 congenital hydronephrotic renal units (RU) (42 unilateral hydronephrosis-29 boys and 13 girls; 12 bilateral hydronephrosis-8 boys and 4 girls) was performed...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29323406/type-and-timing-of-dietary-acid-intake-and-tooth-wear-among-american-adults
#5
Lynn H Al-Zwaylif, Saoirse O'Toole, Eduardo Bernabé
OBJECTIVES: To explore the interrelationship between type and timing of dietary acid intake and tooth wear among American adults. METHODS: This study used data from 3,586 adults, aged 18 years and older, who participated in the National Health and Nutrition Examination Survey (NHANES) 2003-04. Information on four types of acidic food and beverages (fruits, fruit juices, alcoholic drinks, and soft drinks) and timing of consumption (meals versus snacks, defined according to percentage of total energy intake, self-reported eating occasion, and time of day) was extracted from two 24-hour dietary recalls...
January 11, 2018: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/29313277/does-sleeve-shape-make-a-difference-in-outcomes
#6
Adel Alhaj Saleh, Michal R Janik, Rami R Mustafa, Mohammed Alshehri, Adil H Khan, Seyed Mohammad Kalantar Motamedi, Shiraz Rahim, Indravadan Patel, Amir Aryaie, Mujjahid Abbas, Tomasz Rogula, Leena Khaitan
INTRODUCTION: Sleeve gastrectomy (SG) is one of the most common procedures performed for weight loss. Many seek the "perfect sleeve" with the notion that the type of calibrating device affects sleeve shape, and this in turn will affect outcomes and complications. Two major concerns after SG are amount of weight loss and acid reflux. Our aim was to determine if the various calibration methods could impact sleeve shape and thereby allow for better outcomes of weight loss and reflux. METHODS: A retrospective chart review was performed of 210 patients who underwent SG and had postoperative upper gastrointestinal (UGI) study from 2011 to 2015 in a single center by a single (fellowship-trained) bariatric surgeon...
January 8, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29309401/the-characteristics-of-postprandial-proximal-gastric-acid-pocket-in-gastroesophageal-reflux-disease
#7
Jing Wu, Dong Liu, Cheng Feng, Yumei Luo, Yuanyuan Nian, Xueqin Wang, Jun Zhang
BACKGROUND Postprandial proximal gastric acid pocket (PPGAP) plays important roles in gastroesophageal reflux disease (GERD). In this study, we analyzed the characteristics of PPGAP in GERD. MATERIAL AND METHODS There were 17 normal participants and 20 GERD patients who completed a gastroesophageal reflux disease questionnaire (GerdQ) and underwent a gastroscopy, a high-resolution manometry, an esophageal 24-hour pH monitoring, and a station pull-through pH monitoring to assess their symptomatic degree, endoscopic change, acid exposure, and PPGAP...
January 8, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29307999/first-week-clinical-responses-to-dexlansoprazole-60-mg-and-esomeprazole-40-mg-for-the-treatment-of-grades-a-and-b-gastroesophageal-reflux-disease
#8
Chih-Ming Liang, Ming-Te Kuo, Pin-I Hsu, Chao-Hung Kuo, Wei-Chen Tai, Shih-Cheng Yang, Keng-Liang Wu, Hsing-Ming Wang, Chih-Chien Yao, Cheng-En Tsai, Yao-Kuang Wang, Jiunn-Wei Wang, Chih-Fang Huang, Deng-Chyang Wu, Seng-Kee Chuah
AIM: To compare the one-week clinical effects of single doses of dexlansoprazole and esomeprazole on grades A and B erosive esophagitis. METHODS: We enrolled 175 adult patients with gastroesophageal reflux disease (GERD). The patients were randomized in a 1:1 ratio into two sequence groups to define the order in which they received single doses of dexlansoprazole (n = 88) and esomeprazole (n = 87) for an intention-to-treat analysis. The primary end-points were the complete symptom resolution (CSR) rates at days 1, 3, and 7 after drug administration...
December 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29307652/gastro-pharyngeal-reflux-and-total-laryngectomy-increasing-knowledge-about-its-management
#9
Giuditta Mannelli, Roberto Santoro, Francesco Segala, Elisabetta Surrenti, Oreste Gallo
PURPOSE: Investigate the incidence, the degree and the effect of gastro-pharyngeal reflux (GPR) in laryngectomised patients. MATERIALS AND METHODS: Behavioral and 24-hour pH- and impedance-monitoring data were prospectively analyzed for 25 laryngectomised patients with no previous history of GER in outpateints' setting. Reflux detected was characterized as either acid, weakly acidic or nonacid. Proximal reflux was found at 15cm above the LES. RESULTS: 40% of patients presented a pathological number of reflux episodes in the upright position (p<0...
December 11, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29306510/protective-effects-of-artemisia-campestris-extract-against-gastric-acid-reflux-induced-esophageal-mucosa-injuries
#10
Mohamed-Amine Jabri, Haifa Tounsi, Afifa Abdellaoui, Lamjed Marzouki, Hichem Sebai
Artemisia campestris L. has been widely used in alternative medicine to treat digestive system diseases, particularly gastroesophageal disorders. In the present investigation, we studied the putative protective effect of Artemisia campestris aqueous extract (ACAE) against gastro-esophageal reflux (GER)-induced esophagitis in rats. The experimental ophagitis was induced by the ligation of the pylorus as well as the junction between the forestomach and the corpus. We firstly found that ACAE administration at 100, 200 and 400 mg/kg, b...
January 2, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29301258/improvement-in-electrode-performance-of-novel-swcnt-loaded-three-dimensional-porous-rvc-composite-electrodes-by-electrochemical-deposition-method
#11
Ali Aldalbahi, Mostafizur Rahaman, Mohammed Almoigli, Al Yahya Meriey, Khalid N Alharbi
The three-dimensional (3D) composite electrodes were prepared by depositing different amounts of acid-functionalized single-walled carbon nanotubes (a-SWCNTs) on porous reticulated vitreous carbon (RVC) through the electrochemical deposition method. The SWCNT was functionalized by the reflux method in nitric acid and was proven by Raman and visible spectra. The optimum time for sonication to disperse the functionalized SWCNT (a-SWCNT) in dimethyl formamide (DMF) well was determined by UV spectra. The average pore size of RVC electrodes was calculated from scanning electron microscopy (SEM) images...
January 1, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29291345/hierarchical-nanoboxes-composed-of-co9s8-mos2-nanosheets-as-efficient-electrocatalysts-for-hydrogen-evolution-reaction
#12
Vinoth Ganesan, Sunghyun Lim, Jinkwon Kim
Development of hydrogen evolution catalysts based on non-precious metals is essential for the practical application of water-splitting devices. Here, we report the synthesis of Co9S8-MoS2 hierarchical nanoboxes (HNBs) as efficient catalysts for hydrogen evolution reaction (HER). The surface of the hollow cubic structure was organized by CoMoS4 nanosheets formed by the reaction of MoS42- and Co2+ released from the Co-zeolite imidazole framework (ZIF-67) templates under reflux condition in a water-ethanol mixed solvent...
January 1, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29282639/estrogen-dependent-nrf2-expression-protects-against-reflux-induced-esophagitis
#13
Yudai Torihata, Kiyotaka Asanuma, Katsunori Iijima, Tetsuhiko Mikami, Shin Hamada, Naoki Asano, Tomoyuki Koike, Akira Imatani, Atsushi Masamune, Tooru Shimosegawa
BACKGROUND: Gastroesophageal reflux disease is more common in males than in females. The enhanced antioxidative capacity of estrogen in females might account for the gender difference. Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a pivotal role in the host defense mechanism against oxidative stress. AIMS: This study aimed to clarify the role of Nrf2 in reflux-induced esophageal inflammation, focusing on the gender difference and nitric oxide. METHODS: Gastroesophageal reflux was surgically induced in male and female rats...
December 27, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29282636/vonoprazan-a-novel-and-potent-alternative-in-the%C3%A2-treatment-of-acid-related-diseases
#14
REVIEW
Xiaoxiao Yang, Yueyue Li, Yiyuan Sun, Mingming Zhang, Chuanguo Guo, Iqtida Ahmed Mirza, Yan-Qing Li
Although proton pump inhibitors (PPIs) have been used widely, acid-related diseases are still associated with a huge burden on the health care system. Recently, the efficacy and safety of a new acid suppressant named vonoprazan in the treatment of acid-related diseases have been evaluated by a series of studies. As a novel potassium-competitive acid blocker, vonoprazan may provide reversible acid suppression by preventing K+ from binding to gastric H+/K+-ATPase. It has been clinically used for the short-term treatment of gastroesophageal reflux disease (GERD), peptic ulcer disease and Helicobacter pylori (H...
December 27, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29276590/correlation-of-gastroesophageal-reflux-disease-assessment-symptom-questionnaire-to-impedance-ph-measurements-in-children
#15
Sittichoke Prachuapthunyachart, Chaowapong Jarasvaraparn, David A Gremse
Background: Esophageal multichannel intraluminal impedance-pH monitoring has become one of the preferred tests to correlate observed reflux-like behaviors with esophageal reflux events. The Gastroesophageal reflux disease Assessment Symptom Questionnaire is a validated tool used to distinguish infants with gastroesophageal reflux disease from healthy children. The aim of this study was to determine whether the Gastroesophageal reflux disease Assessment Symptom Questionnaire composite symptom scores and individual symptom scores correlate with outcomes in esophageal multichannel intraluminal impedance-pH monitoring...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/29262418/gastro-oesophageal-reflux-and-apnoea-is-there-a-temporal-relationship
#16
Thomas Rossor, Gwendolyn Andradi, Kamal Ali, Ravindra Bhat, Anne Greenough
BACKGROUND: Gastro-oesophageal reflux (GOR) and apnoea are common in infants; whether there is a causal relationship is controversial. OBJECTIVES: To determine whether there was a temporal relationship between GOR and apnoea, in particular, the frequency of obstructive apnoeas and if the frequency of GOR episodes correlated with apnoea frequency when maturity at testing was taken into account. METHODS: Polysomnography and pH/multichannel intraluminal impedance (MII) studies were performed...
December 21, 2017: Neonatology
https://www.readbyqxmd.com/read/29248880/constrictive-bronchiolitis-presenting-with-a-mixed-obstructive-and-restrictive-pattern-associated-with-acid-reflux
#17
Kristen Capel, Richard Dee Shih
A previously healthy 55-year-old woman presented with worsening dyspnoea on exertion. The patient lived at altitude, did not smoke and had no exposure to occupational or environmental toxins. Her physical examination, including pulmonary, was unremarkable. Pulmonary function tests showed forced expiratory volume in 1 s/forced vital capacity ratio 74% predicted, diffusing capacity for carbon monoxide (DLCO) 92% predicted and residual volume 213% predicted. Rheumatological workup was negative. Chest radiograph showed hyperinflation without consolidation, and high-resolution chest CT showed mosaic attenuation with air trapping on expiratory imaging...
December 15, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29245331/when-omeprazole-met-with-asymptomatic-clostridium-difficile-colonization-in-a-postoperative-colon-cancer-patient-a-case-report
#18
Boyu Li, Huachong Ma, Zhenjun Wang, Lihong Liu
RATIONALE: Clostridium difficile infection (CDI) is a symptomatic infection due to the spore-forming bacterium, C. difficile. Asymptomatic C. difficile colonization is the stage in absence of symptoms, with a prevalence of 1.4% to 21% on hospital admission. Proton-pump inhibitors (PPIs) was implicated as a novel potential contributor to CDI. PPIs injection could make asymptomatic C. difficile colonization progress to C. difficile associated diarrhea (CDAD). PATIENT CONCERNS: A postoperative colon cancer patient, who had been taking omeprazole for 4 years after operation, got asymptomatic C...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29243969/low-molecular-weight-oligonol-a-polyphenol-derived-from-lychee-fruit-attenuates-experimental-reflux-esophagitis-and-hcl-ethanol-induced-gastric-ulcer
#19
Seong-Soo Roh, Mi-Rae Shin, Sung Ho Shin, Joo Young Lee, Yeong Ok Song, Minji Woo, Kap-Seop Jeong, Jeong Sook Noh
Oligonol, a polyphenol derived from lychee fruit, is produced by an oligomerization process that converts high-molecular-weight polyphenol polymers into low-molecular-weight oligomers. Evidence suggests that oligonol exerts its beneficial effects based on antioxidant and anti-inflammatory properties. This study was the first to investigate the antioxidative and anti-inflammatory effects of oligonol on gastroesophageal inflammatory models: surgically induced acute reflux esophagitis (RE) and gastric ulcer (GU) induced by HCl/ethanol...
December 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29239501/revisiting-the-ullman-s-radical-chemistry-for-phthalocyanine-derivatives
#20
Catherine Hirel, Ismail Fidan, Dominique Luneau, Vefa Ahsen
Phthalocyanines derivatives does not cease to aroused attention due to their numerous properties and applications (e.g.,sensor, PDT). This makes them unique scaffold for the design of new material. In this expectative, we were interested to develop the synthesis of an imino nitroxyde-substituted phthalocyanine via the Ullman's procedure; a challenge due to intrinsic low solubility of most phthalocyanine derivative in much solvents. To overcome this solubility problem we designed phthalocyanine with bulky neopentyl substituents in peripheral position as counterpart to the imino nitroxyde moieties...
December 14, 2017: Chemistry: a European Journal
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