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https://www.readbyqxmd.com/read/28815866/catalytic-intramolecular-cycloaddition-reactions-using-a-discrete-molecular-architecture
#1
Partha Sarathi Mukherjee, Bijan Roy, Anthonisamy Devaraj, Rupak Saha, Suprita Jharimune, Ki-Whan Chi
A discrete tetragonal tube-shaped complex (MT-1) has been synthesized by coordination-driven self-assembly of a carbazole-based tetraimidazole donor L and a Pd(II) 90° acceptor, viz. [cis-(dppf)Pd(OTf)2] (dppf = diphenylphosphino ferrocene, OTf = CF3SO3-). Complex MT-1 was characterized by multinuclear NMR, ESI-MS and single crystal X-ray diffraction analysis (SCXRD), which showed its symmetrical tetrafacial tube-shaped architecture possessing a large cavity described by four aromatic walls. This coordination cage was successfully utilized as a molecular vessel to perform intramolecular cycloaddition reactions of O-allylated benzylidinebarbituric acid derivatives inside its confined nanospace...
August 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28815026/the-diagnostic-value-of-24-hour-ambulatory-intraesophageal-ph-impedance-in-patients-with-laryngopharyngeal-reflux-symptoms-comparable-with-typical-symptoms
#2
Yusuf S Sakin, Rukiye Vardar, Baha Sezgin, Zeynep Erdogan Cetin, Yasemin Alev, Esra Yildirim, Tayfun Kirazli, Serhat Bor
BACKGROUND: The diagnosis of laryngopharyngeal reflux is currently based on a combination of the patient history of multichannel intraluminal impedance and ambulatory pH (MII-pH); however, none of these findings alone is specific for the diagnosis of laryngopharyngeal reflux. We aimed to compare the baseline characteristics and esophageal baseline impedance values between patients with and without laryngopharyngeal reflux symptoms. METHODS: We retrospectively analyzed data from two groups of patients with laryngopharyngeal reflux according to their reflux finding score (RFS) as scored by ENTs...
August 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28811943/reviewing-the-emergence-of-lactococcus-garvieae-a-case-of-catheter-associated-urinary-tract-infection-caused-by-lactococcus-garvieae-and-escherichia-coli-coinfection
#3
Tatvam T Choksi, Farhan Dadani
Lactococcus garvieae is considered a low virulence organism which is rarely associated with human infections. Most of the reported cases have been associated with bacteremia with or without endocarditis. We report a rare case of catheter associated urinary tract infection (CAUTI) caused by Lactococcus garvieae and Escherichia coli coinfection without any bacteremia in a patient with indwelling urinary catheter placed for benign prostatic hyperplasia (BPH). The patient also had a history of gastroesophageal reflux disease (GERD) with long standing famotidine treatment...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28811016/activated-biochar-preparation-characterization-and-electroanalytical-application-in-an-alternative-strategy-of-nickel-determination
#4
Cristiane Kalinke, Paulo Roberto Oliveira, Geovane Arruda Oliveira, Antonio Sálvio Mangrich, Luiz H Marcolino-Junior, Márcio F Bergamini
This work reports for the first time the use of chemically activated biochar as electrode modifier for nickel determination. The biochar activation was performed by refluxing with HNO3, which promoted a higher nickel preconcentration compared to unmodified and modified biochar precursor electrodes. Morphological and structural characterization revealed the increase of surface acid groups, surface area and porosity of biochar after activation. Nickel determination was investigated adopting an alternative voltammetric methodology based on monitoring the Ni(II)/Ni(III) redox couple...
August 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28808763/characteristics-of-gastroesophageal-reflux-in-pediatric-patients-with-neurological-impairment
#5
Hisayoshi Kawahara, Yuko Tazuke, Hideki Soh, Noriaki Usui, Hiroomi Okuyama
PURPOSE: To clarify the characteristics of gastroesophageal reflux (GER) in pediatric patients with neurological impairment (NI). METHODS: Twenty-six patients with NI, 1-17-year-old, fed via a nasogastric tube were categorized based on the absence (group I) or presence (group II) of abnormal GER, defined with multichannel intraluminal impedance-pH monitoring as %time with an esophageal pH <4.0 being ≥5.0% or number of liquid/mixed bolus reflux events(RE) >70 in 24 h...
August 14, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28808755/the-impact-of-the-location-of-esophagogastrostomy-on-acid-and-duodenogastroesophageal-reflux-after-transthoracic-esophagectomy-with-gastric-tube-reconstruction-and-intrathoracic-esophagogastrostomy
#6
Hiroaki Usui, Masahide Fukaya, Keita Itatsu, Kazushi Miyata, Ryoji Miyahara, Kohei Funasaka, Masato Nagino
BACKGROUND: The aim of this study was to evaluate the impact of the location of esophagogastrostomy on acid and duodenogastroesophageal reflux (DGER) in patients undergoing gastric tube reconstruction and intrathoracic esophagogastrostomy. METHODS: Thirty patients receiving transthoracic esophagectomy without cervical lymph node dissection and gastric tube reconstruction by intrathoracic anastomosis were enrolled. All patients underwent 24-h pH and bilirubin monitoring and gastrointestinal endoscopy one year after surgery...
August 14, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28803237/atf3-dependent-regulation-of-egr1-in-vitro-and-in-vivo
#7
Ilona Schoen, Sabine Koitzsch
BACKGROUND/AIMS: Activating transcription factor 3 (ATF3) and early growth response protein 1 (EGR1) are reported to interact, but their use as prognostic factors in cancer is discussed controversially. METHODS: We measured ATF3 and EGR1 gene expression changes in human mini-organ cultures (MOCs) of healthy nasal epithelia, UM-SCC-22B, and FADUDD cells after acid reflux exposure. Next, ATF3 and EGR1 gene expression was analysed in tumour tissues and related to the median expression of autologous reference tissue samples...
August 12, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28803210/investigation-of-ph-and-substituent-effects-on-the-distribution-ratio-of-novel-steroidal-ring-d-and-a-fused-arylpyrazole-regioisomers-and-evaluation-of-their-cell-growth-inhibitory-effects-in-vitro
#8
Ádám Baji, Ferenc Kovács, Gergő Mótyán, Gyula Schneider, János Wölfling, Izabella Sinka, István Zupkó, Imre Ocsovszki, Éva Frank
Novel androstanopyrazoles have been efficiently synthesized from steroidal β-ketoaldehydes with different arylhydrazine hydrochlorides both under acidic and basic conditions. Knorr-type transformations of 16-hydroxymethylene-dehydroepiandrosterone containing its 1,3-dicarbonyl moiety on ring D, proved to be regioselective in pyridine at room temperature, while mixtures of regioisomers were obtained in acidic EtOH under reflux. Contrarily, the cyclocondensation reactions of 2-hydroxymethylene-dihydrotestosterone bearing its reactive functionalities on ring A, led to a mixture of pyrazole regioisomers in varying ratio depending on the applied medium...
August 9, 2017: Steroids
https://www.readbyqxmd.com/read/28789908/synthesis-and-carbonic-anhydrase-inhibition-of-polycyclic-imides-incorporating-n-benzenesulfonamide-moieties
#9
Andrea Angeli, Alaa A-M Abdel-Aziz, Alessio Nocentini, Adel S El-Azab, Paola Gratteri, Claudiu T Supuran
A series of polycyclic imides was prepared by reaction of the benzenesulfonamide with an appropriate polycyclic acid anhydride in refluxing glacial acetic acid. The synthesized mono- and bis-sulfonamides were evaluated as a carbonic anhydrase inhibitors (CA, EC 4.2.1.1), more precisely against the human (h) isoforms hCA I, II, IX and XII, some of which are involved in various pathologies, such as glaucoma, epilepsy and cancer. Several low nanomolar and isoform-selective hCA II, IX and XII inhibitors were detected, and the structure-activity relationship for CA inhibition with this class of compounds is discussed in details...
July 29, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28780717/proton-pump-inhibitors-in-gastroesophageal-reflux-disease-friend-or-foe
#10
REVIEW
C Prakash Gyawali
PURPOSE OF REVIEW: Proton pump inhibitor (PPI) use in gastroesophageal reflux disease (GERD) has been redefined, in light of recent advances highlighting GERD phenotypes that respond to PPIs, and fresh revelations of potential risks of long-term PPI therapy. RECENT FINDINGS: Erosive esophagitis predicts excellent response to PPI therapy, but non-erosive reflux disease (NERD) with abnormal reflux parameters on ambulatory reflux monitoring also demonstrates a similar response...
September 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28768359/-laryngopharyngeal-reflux-disease-lprd-in-children
#11
Oliver Reichel, Panagiotis Saravakos, Kai J Lorenz
LPRD in children is characterized by symptoms, clinical findings, and sequelae caused by the reflux of gastric acid, bile acid or refluxate containing pepsin beyond the esophagus. For diagnostic procedures and therapy of gastroesophageal reflux disease (GERD) in children and adults widely accepted guidelines have been established. However, diagnosis and therapy of LPRD in children remains a continuous issue of inter- and intradisciplinary discussions. Although both GERD and LPRD in children are reflux-induced diseases, these two entities are different in symptoms, cause, diagnostic procedures, and therapy...
July 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28761692/alteration-in-the-gastric-microbiota-and-its-restoration-by-probiotics-in-patients-with-functional-dyspepsia
#12
Muneki Igarashi, Hirohiko Nakae, Takashi Matsuoka, Shunsuke Takahashi, Takayoshi Hisada, Junko Tomita, Yasuhiro Koga
OBJECTIVE: The objective of this study was to comparatively analyse the gastric fluid (GF) microbiota between patients with functional dyspepsia (FD) and healthy controls (HC), and to assess the effect of probiotics on the microbiota. DESIGN: Twenty-four Japanese patients with FD who met the Rome III definition and 21 age-matched and gender-matched HC volunteers were enrolled. The patients with FD had been treated with LG21, a probiotic strain. The GF was sampled after an overnight fast using a nasogastric tube...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28761578/esophageal-motility-and-rikkunshito-treatment-for-proton-pump-inhibitor-refractory-nonerosive-reflux-disease-a-prospective-uncontrolled-open-label-pilot-study-trial
#13
Takeo Odaka, Shigeru Yamato, Osamu Yokosuka
BACKGROUND: Only a few reports focused on esophageal motility in patients with proton pump inhibitor (PPI)-refractory nonerosive reflux disease (NERD) and there has been no established strategy for treatment. OBJECTIVE: To clarify the characteristics of esophageal motility in patients with PPI-refractory NERD, we evaluated esophageal function using combined multichannel intraluminal impedance and esophageal manometry (MII-EM). In addition, we evaluated the efficacy of rikkunshito (RKT), which is a gastrointestinal prokinetic agent...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28757556/expression-of-serum-exosomal-and-esophageal-microrna-in-rat-reflux-esophagitis
#14
Risa Uemura, Yoshiki Murakami, Atsushi Hashimoto, Akinari Sawada, Koji Otani, Koichi Taira, Shuhei Hosomi, Yasuaki Nagami, Fumio Tanaka, Noriko Kamata, Hirokazu Yamagami, Tetsuya Tanigawa, Toshio Watanabe, Y-H Taguchi, Yasuhiro Fujiwara
Gastroesophageal reflux disease (GERD) is a common upper gastrointestinal disease. However, the role of exosomal microRNAs (miRNAs) and esophageal miRNAs in GERD has not been studied. A rat model of acid reflux esophagitis was used to establish a novel diagnosis marker for GERD and examine dynamics of miRNA expression in GERD. Rats were sacrificed 3 (acute phase), 7 (sub-acute phase) and 21 days (chronic phase) after induction of esophagitis. Exosomes were extracted from serum, and the expression patterns of serum miRNAs were analyzed...
July 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28754071/a-review-of-pharmacotherapy-for-treating-gastroesophageal-reflux-disease-gerd
#15
Edoardo Savarino, Patrizia Zentilin, Elisa Marabotto, Giorgia Bodini, Marco Della Coletta, Marzio Frazzoni, Nicola de Bortoli, Irene Martinucci, Salvatore Tolone, Gaia Pellegatta, Vincenzo Savarino
Medical therapy of gastroesophageal reflux disease (GERD) is based on the use of proton pump inhibitors (PPIs) as first choice treatment. Despite their effectiveness, about 20-30% of patients report an inadequate response and alternative drugs are required. Areas covered: This review provides an overview of current pharmacotherapy for treating GERD by showing the results of PPIs, reflux inhibitors, antidepressants and mucosa protective medications. Expert opinion: Medical therapy of GERD does not definitely cure the disease, because even PPIs are not able to change the key factors responsible for it...
August 7, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28750491/severe-delayed-gastric-emptying-induces-non-acid-reflux-up-to-proximal-esophagus-in-neurologically-impaired-patients
#16
Shinji Ishii, Suguru Fukahori, Kimio Asagiri, Yoshiaki Tanaka, Nobuyuki Saikusa, Naoki Hashizume, Motomu Yoshida, Daisuke Masui, Naoko Komatsuzaki, Naruki Higashidate, Saki Sakamoto, Tomohiro Kurahachi, Shiori Tsuruhisa, Hirotomo Nakahara, Minoru Yagi
Background/Aims: The aim of this study is to investigate the degree of delayed gastric emptying (DGE) and evaluate how the severity of DGE affects gastroesophageal reflux disease (GERD) in neurologically impaired (NI) patients utilizing 24-hour multichannel intraluminal impedance pH measurements (pH/MII) and (13)C-acetate breath test ((13)C-ABT) analyses. Methods: (13)C-ABT and pH/MII were conducted in 26 NI patients who were referred to our institution due to suspected GERD...
July 28, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28749689/superacidic-cyclization-of-activated-anthranilonitriles-into-2-unsubstituted-4-aminoquinolines
#17
Hubert Lavrard, Paolo Larini, Florence Popowycz
4-Aminoquinolines were prepared in a three-step synthesis starting from substituted anthranilonitriles. The condensation on 1,1,1-trichloro-4-ethoxybut-3-enone proceeded efficiently either neat or in refluxing EtOH. Cyclization in superacidic trifluoromethanesulfonic acid provided unstable intermediate, which upon treatment with NaOEt in ethanol, afforded the expected esters. Theoretical investigations pointed out a monoprotonated nitrilium as the reactive species during the cyclization process.
July 27, 2017: Organic Letters
https://www.readbyqxmd.com/read/28748234/erosive-tooth-wear-among-different-tooth-types-and-surfaces-in-japanese-adults-15-to-89-years-old
#18
Yuichi Kitasako, Yoshiyuk Sasaki, Tomohiro Takagaki, Alireza Sadr, Junji Tagami
PURPOSE: To evaluate the prevalence of erosive tooth wear on buccal, incisal/occlusal and palatal/lingual surfaces in a wide age range of Japanese adults. MATERIALS AND METHODS: The study included a total of 1108 adults aged 15 to 89 years in Tokyo, Japan. The subjects were asked to complete a self-administered nutrition-related questionnaire. Two examiners evaluated tooth wear on the buccal, occlusal/incisal and palatal/lingual surfaces in a full-mouth recording, using a modified Smith and Knight tooth-wear index...
July 25, 2017: Oral Health & Preventive Dentistry
https://www.readbyqxmd.com/read/28745196/acid-reflux-treatment-linked-to-higher-risk-of-premature-death
#19
(no author information available yet)
Drugs used to treat acid reflux are linked to a heightened risk of premature death.
July 26, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28740669/impact-of-thoracic-surgery-on-esophageal-motor-function-evaluation-by-high-resolution-manometry
#20
Anja Wäsche, Arne Kandulski, Peter Malfertheiner, Sandra Riedel, Patrick Zardo, Thomas Hachenberg, Jens Schreiber
BACKGROUND: Alteration of esophageal function is a potential risk factor for postoperative complications in thoracic surgery. This prospective study investigates esophageal motility and function during and after thoracic procedures via high resolution manometry (HRM) and impedance technology with spatiotemporal representation of pressure data. METHODS: Twelve consecutive patients eligible for elective thoracic surgery underwent preoperative and postoperative (48 hours and 7 days) esophageal HRM...
June 2017: Journal of Thoracic Disease
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