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Ocular hypertension

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https://www.readbyqxmd.com/read/29772570/undertreatment-of-vascular-risk-factors-in-patients-with-monocular-ischaemic-visual-loss
#1
Angeliki Zarkali, Suk Fun Cheng, Agnes Dados, Robert Simister, Arvind Chandratheva
BACKGROUND AND PURPOSE: Ischaemic visual loss is often considered a lower risk factor than other transient ischaemic attacks (TIA). We aimed to determine the recurrence risk, prevalence and management of vascular risk factors in these patients. METHODS: The study took place in the University College Hospital London daily TIA clinic, main referral centre for North-Central London and Moorfields Eye Hospital. Consecutive records for patients with transient (< 24 h) or permanent (> 24 h) ischaemic visual loss were reviewed during the period January 2014-October 2016...
May 17, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29762268/influence-of-removing-the-large-retinal-vessels-related-effect-on-peripapillary-vessel-density-progression-analysis-in-glaucoma
#2
Gábor Holló
PURPOSE: To investigate the usefulness of removing the large vessel-related information from peripapillary optical coherence tomography (OCT) angiography progression analysis. Peripapillary vessel density (VD) image series which had shown no progression with an earlier software version that did not separate capillary and large vessel-related effects were reevaluated for selective peripapillary capillary VD progression. METHODS: Prospective retinal nerve fiber layer thickness (RNFLT) and peripapillary VD measurements were made using the Angiovue/RTvue-XR OCT on one eye of 9 normal, 20 under treatment ocular hypertensive (OHT) and 24 under treatment open-angle glaucoma patients at 6-month intervals for 2 years (5 visits)...
May 12, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29761382/latanoprostene-bunod-ophthalmic-solution-0-024-a-review-in-open-angle-glaucoma-and-ocular-hypertension
#3
Sheridan M Hoy
Latanoprostene bunod ophthalmic solution 0.024% (hereafter referred to as latanoprostene bunod 0.024%) [Vyzulta™] is a nitric oxide (NO)-donating prostaglandin F2α analogue approved in the USA for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma (OAG) or ocular hypertension. It is thought to lower IOP by increasing aqueous humour outflow through the uveoscleral pathway (mediated by latanoprost acid) and increasing the facility of aqueous humour outflow through the trabecular meshwork pathway (mediated by NO)...
May 14, 2018: Drugs
https://www.readbyqxmd.com/read/29757810/changes-in-ocular-hypotensive-drug-usage-for-glaucoma-treatment-after-cataract-surgery-a-nationwide-population-based-study-in-taiwan
#4
Pei-Yao Chang, Jiun-Yi Wang, Shu-Wen Chang, Yu-Chia Chang
PURPOSE: To observe the changes in the demand for prescriptions of ocular hypertensive drug (OHD) after cataract surgery, to investigate patterns of change in the required OHD amount in open-angle glaucoma (OAG) and angle-closure glaucoma (ACG) cases and to determine the associated factors related to the change. METHODS: This population-based cohort study using the Taiwan National Health Insurance Research Database enrolled patients with glaucoma who underwent bilateral cataract surgeries within 2 years between 2001 and 2012...
May 11, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29757807/thicknesses-of-central-macular-retinal-nerve-fiber-and-ganglion-cell-inner-plexiform-layers-in-patients-with-hypertension
#5
Soo Hyun Lee, Woo Hyuk Lee, Hyung Bin Lim, Young Joon Jo, Jung Yeul Kim
PURPOSE: To compare retinal thickness between patients with chronic hypertension without retinopathy, hypertensive retinopathy, Keith-Wagener-Barker Grade IV status, and normal controls using spectral domain optical coherence tomography. METHODS: In this retrospective study, we analyzed patients who visited our retinal clinic from January 2013 to February 2016. Of those included, 58 eyes of 58 patients were in the healthy control group (Group A), 37 eyes of 37 patients were in the chronic hypertension without retinopathy group (disease duration of at least 10 years; Group B), and 31 eyes of 31 patients with relieved hypertensive retinopathy (Grade IV hypertensive retinopathy a year or more ago but no longer had hypertensive retinopathy at the time of the study; Group C)...
May 11, 2018: Retina
https://www.readbyqxmd.com/read/29750947/glaucoma-specialist-optic-disc-margin-rim-margin-and-rim-width-discordance-in-glaucoma-and-glaucoma-suspect-eyes
#6
Seung Woo Hong, Helen Koenigsman, Ruojin Ren, Hongli Yang, Stuart K Gardiner, Juan Reynaud, Robert M Kinast, Steven L Mansberger, Brad Fortune, Shaban Demirel, Claude F Burgoyne
PURPOSE: To quantify the variability of 5 glaucoma specialists' optic disc margin (DM), rim margin (RM) and rim width (RW) estimates. DESIGN: Inter-Observer Reliability analysis. METHODS: Clinicians viewed stereo-photos from 214 subjects with glaucoma or ocular hypertension and digitally marked the DM and RM. For each photo, the centroid of each clinician's DM was calculated, and an averaged DMcentroid was determined. The axis between the DMcentroid and the fovea was used to establish twelve 30° sectors...
May 8, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29750719/intravenous-hypertonic-saline-to-lower-intraocular-pressure-in-ocular-hypertension-and-primary-open-angle-and-exfoliation-glaucoma
#7
Pia Inborr, Mika Harju, Tero T Kivelä
PURPOSE: To quantitate the effect of intravenous hypertonic saline on elevated intraocular pressure (IOP) among three groups of glaucoma patients or suspects. MATERIAL AND METHODS: Forty-four patients with IOP 24-30▒mm Hg; 13 had ocular hypertension (OHT), 14 primary open-angle glaucoma (POAG), and 17 exfoliation glaucoma (ExG). Participants received a bolus of 23.4% intravenous hypertonic saline (1.0▒mmol/kg) through an antecubital vein. We measured IOP, heart rate, and blood pressure before the bolus, afterwards every minute for 10 minutes, and less frequently for 2 hours...
May 10, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29750717/effect-of-latanoprost-on-choroidal-thickness
#8
Nedime Sahinoglu-Keskek, Handan Canan
PURPOSE: To evaluate the changes in choroidal thickness during the use of latanoprost eyedrops which shift fluid to the suprachoroidal space and change choroidal perfusion. METHODS: This prospective study included 34 eyes of 17 bilateral glaucoma or ocular hypertensive patients who had no previous hypotensive therapy. Each patient had both eyes treated with latanoprost. Each patient also underwent a complete ophthalmological examination and optical coherence tomography (OCT) measurement...
May 10, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29750714/non-invasive-detection-of-mitochondrial-dysfunction-in-ocular-hypertension-and-primary-open-angle-glaucoma
#9
Lawrence S Geyman, Yanin Suwan, Reena Garg, Matthew G Field, Brian D Krawitz, Shelley Mo, Alexander Pinhas, Robert Ritch, Richard B Rosen
PURPOSE: To assess mitochondrial dysfunction in vivo in ocular hypertension (OHT) and primary open-angle glaucoma (POAG) using retinal metabolic analysis. PATIENTS AND METHODS: This was an observational, cross-sectional study performed from November 2015 to October 2016 at the New York Eye and Ear Infirmary of Mount Sinai. Thirty-eight eyes with varying stages of POAG, 16 eyes with OHT, and 32 control eyes were imaged on a custom fundus camera modified to measure full retinal thickness fluorescence at a wavelength optimized to detect flavoprotein fluorescence (FPF)...
May 10, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29743238/transforming-growth-factor-%C3%AE-2-tgf%C3%AE-2-signaling-plays-a-key-role-in-glucocorticoid-induced-ocular-hypertension
#10
Ramesh B Kasetti, Prabhavathi Maddineni, Pinkal Patel, Charles Searby, Val C Sheffield, Gulab S Zode
Elevation of intraocular pressure (IOP) is a serious adverse effect of glucocorticoid (GC) therapy. Increased extracellular matrix (ECM) accumulation and endoplasmic reticulum (ER) stress in the trabecular meshwork (TM) is associated with GC-induced IOP elevation. However, the molecular mechanisms by which GCs induce ECM accumulation and ER stress in the TM have not been determined. Here, we show that a potent GC, dexamethasone (Dex), activates transforming growth factor β (TGFβ) signaling, leading to GC-induced ECM accumulation, ER stress and IOP elevation...
May 9, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29740393/comparison-of-ocular-ultrasonography-and-magnetic-resonance-imaging-for-detection-of-increased-intracranial-pressure
#11
David F Patterson, Mai-Lan Ho, Jacqueline A Leavitt, Nathan J Smischney, Sara E Hocker, Eelco F Wijdicks, David O Hodge, John Jing-Wei Chen
Background/aims: To evaluate and compare the performance of ocular ultrasonography (US) and magnetic resonance imaging (MRI) for detecting increased intracranial pressure (ICP) in patients with idiopathic intracranial hypertension (IIH). Methods: Twenty-two patients with papilledema from IIH and 22 with pseudopapilledema were prospectively recruited based on funduscopic and clinical findings. Measurements of optic nerve sheath diameters (ONSDs) 3 mm behind the inner sclera were performed on B-scan US and axial T2-weighted MRI examinations...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29739991/systemic-hypertension-is-not-protective-against-chronic-intraocular-pressure-elevation-in-a-rodent-model
#12
Anna K van Koeverden, Zheng He, Christine T O Nguyen, Algis J Vingrys, Bang V Bui
High intraocular pressure is the most well documented glaucoma risk factor; however many patients develop and/or show progression of glaucoma in its absence. It is now thought that in some instances, ocular perfusion pressure (blood pressure - intraocular pressure) may be as important as intraocular pressure alone. Thus, systemic hypertension would be protective against glaucoma. Epidemiological studies, however, are inconclusive. One theory of why hypertension may not protect against elevated intraocular pressure in spite of increasing ocular perfusion pressure is that with time, morphological changes to the vasculature and autoregulatory failure outweigh the benefits of improved perfusion pressure, ultimately leading to poor retinal and optic nerve head blood supply...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29736322/oral-omega-3-supplementation-lowers-intraocular-pressure-in-normotensive-adults
#13
Laura Elizabeth Downie, Algis Jonas Vingrys
Purpose: Elevated intraocular pressure (IOP) is the major modifiable risk factor for the sight-threatening eye disease, glaucoma. We investigated whether oral omega-3 supplements affect IOP in normotensive adults. Methods: We undertook a pooled analysis of data from two double-masked, placebo-controlled randomized trials (Australian New Zealand Clinical Trials Registry, ACTRN12614001019695, ACTRN12615000173594) that investigated the efficacy and safety of oral omega-3 supplementation for treating ocular surface inflammation...
May 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29733899/cataract-development-associated-with-long-term-glucocorticoid-therapy-in-duchenne-muscular-dystrophy-patients
#14
Melissa L Rice, Brenda Wong, Paul S Horn, Michael B Yang
PURPOSE: To evaluate the development of cataracts or ocular hypertension in patients with Duchenne muscular dystrophy (DMD) on long-term GC treatment. METHODS: The medical records of DMD patients evaluated from 2010 to 2015 at a single center were reviewed retrospectively. The main outcome measures were prevalence of cataracts and ocular hypertension, age of first detection of cataract, time from initial steroid use to first detection of cataract, and relative risk of cataract development for deflazacort versus prednisone treatment...
May 4, 2018: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29732441/quantitative-oct-angiography-evaluation-of-peripapillary-retinal-circulation-after-plaque-brachytherapy
#15
Alison H Skalet, Liang Liu, Christina Binder, Audra K Miller, Jie Wang, David J Wilson, Richard Crilly, Charles R Thomas, Arthur Y Hung, David Huang, Yali Jia
Objective: To study peripapillary retinal capillary circulation in eyes treated with I-125 plaque brachytherapy for uveal melanoma using optical coherence tomography angiography (OCTA). Design: Cross-sectional study of 10 subjects imaged with OCTA prior to uveal melanoma treatment and 15 subjects imaged after development of radiation retinopathy and/or optic neuropathy. Participants: Following IRB approval, subjects were enrolled from an academic ocular oncology clinical practice...
March 2018: Ophthalmology retina
https://www.readbyqxmd.com/read/29721842/pigment-dispersion-syndrome-and-pigmentary-glaucoma-a-review-and-update
#16
Gianluca Scuderi, Maria Teresa Contestabile, Luca Scuderi, Aloisa Librando, Vito Fenicia, Siavash Rahimi
INTRODUCTION: Potential factors influencing stereopsis were investigated in patients with both refractive accommodative esotropia (RAE) and amblyopia. Pigment dispersion syndrome (PDS) is a condition where anomalous iridozonular contact leads to pigment dispersion throughout the anterior segment and the released pigment is abnormally deposited on various ocular structures. CLINICAL PRESENTATION: The clinical presentation of PDS is defined by the presence of pigmented cells on the corneal endothelium, an increase of pigmentation of the trabecular meshwork, and mid-periphery transillumination defects of the iris...
May 2, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29721442/phacoemulsification-of-bilateral-cataracts-in-two-pet-rabbits
#17
Filipe Espinheira Gomes, Ricardo de Matos, Eric Ledbetter
Two 3 year-old, healthy, client-owned Lop rabbits presented with bilateral cataracts. After performing a physical examination, bloodwork, ocular ultrasonography and electroretinography, both animals were deemed good surgical candidates for phacoemulsification. Bilateral cataract surgery was performed and both rabbits regained vision in both eyes. Both animals developed post-operative ocular hypertension and one animal developed corneal ulcers immediately after surgery. Both surgical complications resolved with medical management...
2018: Open Veterinary Journal
https://www.readbyqxmd.com/read/29721307/intraocular-pressure-elevation-precedes-a-phagocytosis-decline-in-a-model-of-pigmentary-glaucoma
#18
Yalong Dang, Susannah Waxman, Chao Wang, Priyal Shah, Ralitsa T Loewen, Nils A Loewen
Background: Outflow regulation and phagocytosis are key functions of the trabecular meshwork (TM), but it is not clear how the two are related in secondary open angle glaucomas characterized by an increased particle load. We hypothesized that diminished TM phagocytosis is not the primary cause of early ocular hypertension and recreated pigment dispersion in a porcine ex vivo model. Methods: Sixteen porcine anterior chamber cultures received a continuous infusion of pigment granules (Pg), while 16 additional anterior chambers served as controls (C)...
2018: F1000Research
https://www.readbyqxmd.com/read/29716786/systemic-and-ocular-determinants-of-peripapillary-retinal-nerve-fiber-layer-thickness-measurements-in-the-european-eye-epidemiology-e3-population
#19
Matthias M Mauschitz, Pieter W M Bonnemaijer, Kersten Diers, Franziska G Rauscher, Tobias Elze, Christoph Engel, Markus Loeffler, Johanna Maria Colijn, M Arfan Ikram, Johannes R Vingerling, Katie M Williams, Christopher J Hammond, Catherine Creuzot-Garcher, Alain M Bron, Rufino Silva, Sandrina Nunes, Cécile Delcourt, Audrey Cougnard-Grégoire, Frank G Holz, Caroline C W Klaver, Monique M B Breteler, Robert P Finger
PURPOSE: To investigate systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness (pRNFLT) in the European population. DESIGN: Cross-sectional meta-analysis. PARTICIPANTS: A total of 16 084 European adults from 8 cohort studies (mean age range, 56.9±12.3-82.1±4.2 years) of the European Eye Epidemiology (E3) consortium. METHODS: We examined associations with pRNFLT measured by spectral-domain OCT in each study using multivariable linear regression and pooled results using random effects meta-analysis...
April 28, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29708927/cytomegalovirus-keratitis
#20
Samuel C Faith, Asad F Durrani, Vishal Jhanji
PURPOSE OF REVIEW: Cytomegalovirus (CMV) keratitis, albeit an uncommon manifestation of this ubiquitous pathogen, can lead to devastating ocular morbidity. Timely diagnosis and appropriate treatment are also unfortunately uncommon. The purpose of this review is to discuss recently published literature regarding the epidemiology, pathophysiology, diagnosis, and therapy of CMV keratitis. RECENT FINDINGS: Classic clinical presentations of CMV keratitis are known; however, current investigations further elucidate characteristics of typical versus atypical disease...
April 27, 2018: Current Opinion in Ophthalmology
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