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https://www.readbyqxmd.com/read/29332128/pharmacologic-characterization-of-omidenepag-isopropyl-a-novel-selective-ep2-receptor-agonist-as-an-ocular-hypotensive-agent
#1
Tomoko Kirihara, Takazumi Taniguchi, Kenzo Yamamura, Ryo Iwamura, Kenji Yoneda, Noriko Odani-Kawabata, Atsushi Shimazaki, Takeshi Matsugi, Naveed Shams, Jin-Zhong Zhang
Purpose: The objective of this study was to investigate the pharmacologic characteristics of omidenepag isopropyl (OMDI), a compound developed as a novel intraocular pressure (IOP)-lowering agent, with better IOP control and fewer side effects than other prostanoid receptor agonists such as prostaglandin F receptor (FP) agonists. Methods: Binding activities of OMDI and its hydrolyzed form, omidenepag (OMD), to human recombinant prostanoid receptors (DP1-2, EP1-4, FP, and IP) were evaluated...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29331294/-study-of-the-results-scleral-fixated-intraocular-lenses-in-the-absence-of-capsular-support
#2
A Benarous, A Drimbea, S Milazzo
INTRODUCTION: In the absence of sufficient capsular support, scleral fixation of the intraocular lens is an interesting alternative. The goal is to evaluate this implantation technique when traditional implantation is impossible. PATIENTS AND METHODS: This is an observational, retrospective, monocentric study at the Amiens university medical center between August 2013 and March 2016. Patients all underwent scleral fixation of a three-piece implant without suturing of the haptics, after posterior vitrectomy...
January 10, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29330811/a-nationwide-survey-of-factors-influencing-adherence-to-ocular-hypotensive-eyedrops-in-japan
#3
Toyoaki Tsumura, Kenji Kashiwagi, Yasuyuki Suzuki, Keiji Yoshikawa, Hirotaka Suzumura, Toshine Maeda, Ryuji Takeda, Hitomi Saito, Makoto Araie
INTRODUCTION: Few reports have investigated the status of adherence in Japan on a large scale. We aimed to investigate the status of adherence to topical glaucoma treatment and its associated factors. METHODS: A nationwide survey was conducted as a prospective fashion. Participants in this survey were subjects with primary open-angle glaucoma, normal-tension glaucoma, or ocular hypertension or pseudoexfoliation glaucoma who had been prescribed anti-glaucoma ophthalmic eyedrops and whose ophthalmologist considered prescribing any fixed combination of ocular hypotensive eyedrops for the first time between 2011 and 2012...
January 12, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29328064/south-african-eye-study-saes-ethnic-differences-in-central-corneal-thickness-and-intraocular-pressure
#4
S O Baboolal, D P Smit
PurposeGlaucoma is the leading cause of irreversible blindness worldwide. South Africa has a diverse population but there is a lack of published ethnic specific normative data. The purpose of the study is to determine the distribution of intraocular pressure (IOP) and central corneal thickness (CCT) values in a multi-ethnic South African population and to determine additional systemic and ocular factors that influence IOP and CCT.Patients and methodsThis cross-sectional study included a total of 402 participants with 706 eyes aged 18-94 years...
January 12, 2018: Eye
https://www.readbyqxmd.com/read/29326065/hydrogen-sulfide-supplement-attenuates-the-apoptosis-of-retinal-ganglion-cells-in-experimental-glaucoma
#5
Shouyue Huang, Ping Huang, Zhongjing Lin, Xiaohong Liu, Xing Xu, Lei Guo, Xi Shen, Changwei Li, Yisheng Zhong
Glaucoma is a group of neurodegenerative eye diseases characterized by progressive impairment of visual function due to loss of retinal ganglion cells (RGC). As hydrogen sulfide (H2S) was reported to play a role in the process of glaucomatous neuropathy and improve RGC survival in experimental glaucoma, the authors aimed to investigate the anti-apoptosis effect of H2S supplement in a rat glaucoma model, and further tried to explore the involved factors in the neuroprotection. A chronic ocular hypertension (COH) rat model induced by intracameral injection of cross-linking hydrogel was employed to simulate glaucoma and 288 rats were subjected to experimental procedures in the present study...
January 8, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29323613/idrugs-and-idevices-discovery-research-preclinical-assays-techniques-and-animal-model-studies-for-ocular-hypotensives-and-neuroprotectants
#6
Najam A Sharif
Discovery ophthalmic research is centered around delineating the molecular and cellular basis of ocular diseases and finding and exploiting molecular and genetic pathways associated with them. From such studies it is possible to determine suitable intervention points to address the disease process and hopefully to discover therapeutics to treat them. An investigational new drug (IND) filing for a new small-molecule drug, peptide, antibody, genetic treatment, or a device with global health authorities requires a number of preclinical studies to provide necessary safety and efficacy data...
January 11, 2018: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29320472/subjective-complaints-of-ocular-dryness-and-xerostomia-among-the-non-sj%C3%A3-gren-adult-population-of-lublin-region-poland
#7
Renata Chałas, Dorota Rykwa, Dominika Wróbel-Dudzińska, Tomasz Żarnowski
BACKGROUND Eye and mouth dryness are the most common symptoms reported during ophthalmological and dental examinations, and their frequency increases with age. In connection with population aging and the huge variety of factors and conditions that can induce this condition, it is becoming a serious and growing problem. The purpose of the present study was to determine whether ocular dryness and concomitant xerostomia is associated with particular systemic diseases. MATERIAL AND METHODS We enrolled 642 non-Sjögren patients referred for examination to the ophthalmology or dental clinic of Lublin region, Poland...
January 10, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29309745/alterations-of-ocular-hemodynamics-impair-ophthalmic-vascular-and-neuroretinal-function
#8
Shu-Huai Tsai, Wankun Xie, Min Zhao, Robert H Rosa, Travis W Hein, Lih Kuo
Hypertension is associated with numerous diseases, but its direct impact on the ocular circulation and neuroretinal function remains unclear. Herein, mouse eyes were challenged with different levels of hemodynamic insult via transverse aortic coarctation, which increased blood pressure and flow velocity by 50% and 40%, respectively, in the right common carotid artery, and reduced those parameters by 30% and 40%, respectively, in the left common carotid artery. Blood velocity in the right central retinal artery gradually increased up to 40% at four weeks of transverse aortic coarctation, and the velocity in the left central retinal artery gradually decreased by 20%...
January 5, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29303879/comparison-of-peripapillary-oct-angiography-vessel-density-and-retinal-nerve-fiber-layer-thickness-measurements-for-their-ability-to-detect-progression-in-glaucoma
#9
Gábor Holló
PURPOSE: To investigate the applicability of peripapillary optical coherence tomography angiography angioflow vessel-density measurements in the retinal nerve fiber layer for the detection of glaucomatous progression; and to compare its performance with that of retinal nerve fiber layer thickness (RNFLT) measurements. METHODS: Prospective RNFLT and vessel-density measurements with the same Angiovue/RTVue-XR instrument were made immediately after each other on one eye of 9 normal, 20 under treatment ocular hypertensive (OHT) and 24 under treatment open-angle glaucoma patients at 6-month intervals for 2 years (5 visits for all eyes)...
January 4, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29303146/selective-laser-trabeculoplasty-past-present-and-future
#10
REVIEW
A Garg, G Gazzard
Over the past two decades, selective laser trabeculoplasty (SLT) has increasingly become an established laser treatment used to lower intraocular pressure in open-angle glaucoma and ocular hypertensive patients. In this review we trace the origins of SLT from previous argon laser trabeculoplasty and review the current role it has in clinical practice. We outline future directions of SLT research and introduce emerging technologies that are further developing this intervention in the treatment paradigm of glaucoma...
January 5, 2018: Eye
https://www.readbyqxmd.com/read/29290461/oculomotor-palsy-in-diabetics
#11
H Lajmi, W Hmaied, W Ben Jalel, Z Chelly, A Ben Yakhlef, F Ben Zineb, L El Fekih
INTRODUCTION: Oculomotor palsy is one of the most frequent neuro-ophthalmologic complications of diabetic patients. It generates less interest in the literature than the other ocular manifestations. Our goal was to study the clinical, epidemiological, therapeutic and prognostic characteristics of oculomotor palsy in the diabetic. METHODS: This is a retrospective study of 24 diabetic patients with oculomotor palsy. The ophthalmological examination emphasized ocular motility...
December 28, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29288267/pi3k-akt-pathway-a-role-in-%C3%AE-opioid-receptor-mediated-rgc-neuroprotection
#12
Shahid Husain, Anis Ahmad, Sudha Singh, Carolyn Peterseim, Yasir Abdul, Matthew J Nutaitis
Purpose: This study examines the role of PI3K/Akt pathway in δ-opioid receptor agonist (SNC-121)-induced RGC neuroprotection in a chronic glaucoma rat model. Methods: Injecting hypertonic saline into the limbal veins of Brown Norway rats elevated IOP. Rats were treated either with 1 mg/kg SNC-121 or 3 mg/kg 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride (LY-294002; PI3K/Akt inhibitor) plus SNC-121 once daily for 7 days. Pattern ERGs were recorded in response to contrast reversal of patterned visual stimuli...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29279654/intravitreal-bevacizumab-for-choroidal-neovascularization-associated-with-angioid-streaks-long-term-results
#13
T Lekha, Hari Narayan Prasad, Renuka Nikit Sarwate, Manasi Patel, S Karthikeyan
PURPOSE: The purpose of the study was to evaluate the long-term efficacy and safety of intravitreal bevacizumab (IVB) in the treatment of choroidal neovascularization (CNV) secondary to angioid streaks (AS). MATERIALS AND METHODS: Noncomparative, interventional retrospective case series involving ten patients (15 eyes) with a minimum follow-up of 25 months following IVB for AS-associated CNV. Demographic and clinical details at baseline and during follow-up were collected from patient records...
July 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/29260095/hypertensive-retinopathy-as-the-initial-presentation-of-neuroblastoma
#14
Anna Djougarian, Sylvia Kodsi
Purpose: To describe a case of a patient who presented with hypertensive retinopathy and was found to have neuroblastoma. Observations: Neuroblastoma has three main ocular presentations. As a primary disease, it can present with a paraneoplastic syndrome in the form of opsoclonus, or it can present as a Horner's syndrome from its effect on the cervical sympathetic ganglia. Metastatic disease can present as a triad of periorbital edema, ecchymosis and proptosis from orbital bone involvement...
September 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29259915/paracentesis-following-intravitreal-drug-injections-in-maintaining-physiologic-ocular-perfusion-pressure
#15
Austin Bach, Artur Filipowicz, Aaron S Gold, Azeema Latiff, Timothy G Murray
A retrospective analysis was performed of patients who received a paracentesis immediately following an intravitreal injection of bevacizumab or triamcinolone acetonide. These patients were previously diagnosed as having glaucoma, ocular hypertension, or had responded previously with sustained elevated intraocular pressure. Of 1661 procedures were performed. Totally 219 (13%) of the injections were on phakic patients. A median (SD) of 210 µL (40 µL) of aqueous was removed during each paracentesis. There were no reported incidences of any complications...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29229444/neural-control-of-choroidal-blood-flow
#16
REVIEW
Anton Reiner, Malinda E C Fitzgerald, Nobel Del Mar, Chunyan Li
The choroid is richly innervated by parasympathetic, sympathetic and trigeminal sensory nerve fibers that regulate choroidal blood flow in birds and mammals, and presumably other vertebrate classes as well. The parasympathetic innervation has been shown to vasodilate and increase choroidal blood flow, the sympathetic input has been shown to vasoconstrict and decrease choroidal blood flow, and the sensory input has been shown to both convey pain and thermal information centrally and act locally to vasodilate and increase choroidal blood flow...
December 8, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29229111/toxicity-risk-from-glucocorticoids-in-sarcoidosis-patients
#17
Nauman A Khan, Christopher V Donatelli, Adriano R Tonelli, Jonathan Wiesen, Manuel L Ribeiro Neto, Debasis Sahoo, Daniel A Culver
BACKGROUND: Glucocorticoids (GC) are considered first-line therapy for treating sarcoidosis, but there are few data about the adverse consequences of GC. Although there are several steroid-sparing medications available for treatment, a large proportion of patients are treated with prolonged courses of GC. The toxicities of GC in sarcoidosis populations have not been carefully evaluated. METHODS: We performed a retrospective cohort study of all newly diagnosed sarcoidosis patients who had the entirety of their medical care in a single health system...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29223238/pupillary-block-glaucoma-secondary-to%C3%A2-central-port-occlusion-following-insertion-of-a-phakic-implantable-copolymer-lens
#18
Felix Gonzalez-Lopez, Rafael Bilbao-Calabuig, Ricardo Alen, Blas Mompean
A 28-year-old woman had uneventful implantation of a phakic intraocular lens (pIOL) in her left eye (Visian ICL, EVO+ model, 13.2, -7.50 diopters) to correct myopia. Six days after the procedure, she presented with herniation of the iris. Surgical reduction was carried out successfully through the previous peripheral corneal paracentesis. On the following day, the patient reported ocular pain and blurry vision. Examination showed a shallow anterior chamber, moderate diffuse corneal edema, and ocular hypertension...
November 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29222550/tissue-transglutaminase-elevates-intraocular-pressure-in-mice
#19
Urmimala Raychaudhuri, J Cameron Millar, Abbot F Clark
Purpose: Tissue transglutaminase (TGM2) is elevated in glaucomatous trabecular meshwork (TM) tissues. We investigated whether increased expression of TGM2 increases extracellular matrix crosslinking in the TM, thereby increasing aqueous humor outflow resistance and elevating intraocular pressure (IOP) in mouse eyes. Methods: GTM3, primary human GTM 125-05, and cultured mouse TM cells were transduced with adenovirus serotype 5 expressing human transglutaminase 2 (Ad5...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29215307/effects-of-intravitreous-sodium-hydrosulfide-on-intraocular-pressure-and-retinopathy-in-ocular-hypertensive-rats
#20
M A Özer, Z Erişgin, S Özen, Y Tekelioğlu, S Takır
We investigated the possible neuroprotectant and intraocular pressure (IOP) lowering effects of intravitreous injection of sodium hydrosulfide (NaSH) in a rodent model of experimental glaucoma. Glaucoma currently is treated by controlling IOP using medications and/or surgery. These methods are not entirely adequate for all patients. We divided 24 rats into three groups. For the control group, the right eye was treated with intravitreous saline. For the glaucoma group, ocular hypertension was induced by photocoagulating three episcleral veins and the limbal plexus of the right eye using an argon laser, then saline was injected into the vitreous of these eyes during the third week...
December 7, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
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