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https://www.readbyqxmd.com/read/28437175/pharmacokinetics-and-safety-of-travoprost-0-004-ophthalmic-solution-preserved-with-polyquad-in-pediatric-patients-with-glaucoma
#1
Erin Stahl, Dominique Bremond-Gignac, Theresa Landry, Mike Curtis, Kinfemichael Gedif, Sami Al Shahwan, El Roy Dixon
PURPOSE: To evaluate the systemic pharmacokinetics (PKs) of travoprost 0.004% preserved with Polyquad(®) (TRAVATAN(®)) in pediatric patients with glaucoma or ocular hypertension. METHODS: This was a phase 1, open-label, multicenter clinical study of patients aged ≥2 months to <18 years. Patients received daily administration of travoprost 0.004% preserved with Polyquad in both eyes for 7 days. Plasma samples were collected 30 min before the final dose and at 10, 20, 40, and 80 min postdose...
February 24, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28433444/risk-of-ocular-hypertension-in-adults-with-noninfectious-uveitis
#2
Ebenezer Daniel, Maxwell Pistilli, Srishti Kothari, Naira Khachatryan, R Oktay Kaçmaz, Sapna S Gangaputra, H Nida Sen, Eric B Suhler, Jennifer E Thorne, C Stephen Foster, Douglas A Jabs, Robert B Nussenblatt, James T Rosenbaum, Grace A Levy-Clarke, Nirali P Bhatt, John H Kempen
PURPOSE: To describe the risk and risk factors for ocular hypertension (OHT) in adults with noninfectious uveitis. DESIGN: Retrospective, multicenter, cohort study. PARTICIPANTS: Patients aged ≥18 years with noninfectious uveitis seen between 1979 and 2007 at 5 tertiary uveitis clinics. METHODS: Demographic, ocular, and treatment data were extracted from medical records of uveitis cases. MAIN OUTCOME MEASURES: Prevalent and incident OHT with intraocular pressures (IOPs) of ≥21 mmHg, ≥30 mmHg, and increase of ≥10 mmHg from documented IOP recordings (or use of treatment for OHT)...
April 19, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28430806/incidence-and-risk-factors-for-post-penetrating-keratoplasty-glaucoma-a-systematic-review-and-meta-analysis
#3
Suqian Wu, Jianjiang Xu
OBJECTIVES: To establish the incidence and risk factors for post penetrating keratoplasty glaucoma (PKKG). METHODS: Studies published between 1947 and 2016 regarding penetrating keratoplasty (PK) were identified using an electronic search and reviewed. For search purpose, PKKG was defined as ocular hypertension (> 21mmHg) after PK. The incidence and risk factors of PKKG were extracted for all studies. Pooled incidence, odd ratios (ORs) and 95% confidence intervals (CIs) were calculated...
2017: PloS One
https://www.readbyqxmd.com/read/28426628/ocular-hypertension-and-glaucoma-following-vitrectomy-a-systematic-review
#4
Alba Miele, Andrea Govetto, Carlo Fumagalli, Simone Donati, Ilaria Biagini, Claudio Azzolini, Stanislao Rizzo, Gianni Virgili
PURPOSE: Pars plana vitrectomy has been reported to increase the risk of ocular hypertension and open-angle glaucoma. The authors conducted a systematic review of randomized and nonrandomized studies to compare the incidence of open-angle glaucoma and ocular hypertension in vitrectomized versus nonvitrectomized eyes. METHODS: A literature search was performed using MEDLINE and EMBASE until August 2016. Data on ocular hypertension and open-angle glaucoma incidence and mean intraocular pressure after at least 1 year were pooled using random-effects metaanalysis models...
April 19, 2017: Retina
https://www.readbyqxmd.com/read/28410723/risk-factors-predicting-steroid-induced-ocular-hypertension-after-photorefractive-keratectomy
#5
Yumna Busool, Michael Mimouni, Igor Vainer, Shmuel Levartovsky, Tzahi Sela, Gur Munzer, Igor Kaiserman
PURPOSE: To assess the risk factors contributing to steroid-induced ocular hypertension after photorefractive keratectomy (PRK). SETTING: Care Laser Centers, Tel Aviv, Israel. DESIGN: Retrospective case series. METHODS: Patients having PRK between January 2000 and December 2015 were followed for at least 3 months. Intraocular pressure (IOP) was measured using the Goldmann applanation tonometer after 1 week and after 1, 3, and 6 months...
March 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28408797/ocular-hypotensive-effects-of-a-rho-associated-protein-kinase-inhibitor-in-rabbits
#6
Muhammad Irfan Kamaruddin, Momoko Nakamura-Shibasaki, Yu Mizuno, Yoshiaki Kiuchi
PURPOSE: Ripasudil is a novel Rho-associated protein kinase inhibitor that is used to treat ocular hypertension. However, the comparison of the intraocular pressure (IOP)-lowering effects between ripasudil alone and other ocular hypotensive drugs has not been studied thoroughly. The purpose of this study is to examine the ocular hypotensive effects of 0.4% ripasudil, 2% pilocarpine, 0.5% timolol and 0.1% dorzolamide in rabbits. We also studied the IOP changes when 0.4% ripasudil was combined with 2% pilocarpine, 0...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28399831/characteristics-of-cases-needing-advanced-treatment-for-intractable-posner-schlossman-syndrome
#7
Kazuichi Maruyama, Yuko Maruyama, Sunao Sugita, Kazuhiko Mori, Yu Yokoyama, Shiho Sanuki-Kunimatsu, Hiroko Nakagawa, Shigeru Kinoshita, Manabu Mochizuki, Toru Nakazawa
BACKGROUND: In Posner-Schlossman syndrome (PSS), which is characterized by recurrent unilateral attacks of ocular hypertension. Surgical treatment is sometimes necessary because intraocular pressure (IOP) cannot be controlled with anti-glaucoma medications. To identify the clinical features of Posner-Schlossman syndrome (PSS) indicative of the need for intraocular pressure (IOP)-controlling surgery. METHODS: This study was a retrospective case-series analysis of the clinical charts of 33 patients diagnosed with PSS, who underwent surgery to control IOP or received medication only...
April 11, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28398939/acute-unilateral-vision-loss-in-a-female-adolescent-due-to-ocular-bartonellosis
#8
Douglas S Nassif
Acute worsening of visual acuity with optic disc edema is commonly assumed to be due to idiopathic intracranial hypertension. Bartonella henselae is an unusual cause to abrupt vision loss that is associated with optic disc edema and exudative macular stars seen on examination. It is an important cause to be aware of because it responds very well to antibiotic treatment. We present a case of a female adolescent with unilateral vision loss cause by cat-scratch neuroretinitis.
April 11, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28395904/-intraocular-ferritin-production-due-to-an-iron-containing-intraocular-foreign-body
#9
F El Boukhrissi, A Laktaoui, A Hommadi, Y Bamou, L Balouch
INTRODUCTION: Ocular siderosis is a rare but severe complication of open globe trauma with intraocular retention of a metallic foreign body. CASE STUDY: We report a case of recurrent uveitis in a 37-year-old patient. The ophthalmic examination revealed poor vision in the left eye, lid edema, limbal scleromalacia, hyphema and severe ocular hypertension. Orbital CT showed the presence of a radio-opaque IOFB between the crystalline lens and vitreous body. An aqueous humor sample was obtained for iron and ferritin levels...
April 8, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28391624/nitric-oxide-in-the-pathophysiology-of-retinopathy-evidences-from-preclinical-and-clinical-researches
#10
REVIEW
Radka Opatrilova, Peter Kubatka, Martin Caprnda, Dietrich Büsselberg, Vladimir Krasnik, Pavol Vesely, Sandeep Saxena, Surabhi Ruia, Ioana Mozos, Luis Rodrigo, Peter Kruzliak, Katia Goncalves Dos Santos
Retinopathy is the leading cause of blindness and visual disability in working-aged people. The pathogenesis of retinopathy is an actual and still open query. Alterations contributing to oxidative and nitrosative stress, including elevated nitric oxide and superoxide production, changes in the expression of different isoforms of nitric oxide synthase or endogenous antioxidant system, have been implicated in the mechanisms how this ocular disease develops. In addition, it was documented that renin-angiotensin system has been implicated in the progression of retinopathy...
April 8, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28390895/observation-and-characterization-of-microvascular-vasomotion-using-erythrocyte-mediated-icg-angiography-em-icg-a
#11
Robert W Flower, Ronn Kling
A clinical method for characterizing the state of micro-vasculature vasomotion is demonstrated, based on observing in capillaries the dynamics of autologously re-injected erythrocytes containing ICG dye. Since a manifestation of vasomotion is transient erythrocyte pausing, vasomotion state within a field of capillaries is characterized by an histogram plot of the number of paused erythrocytes as a function of pause duration during a fixed period of observation, then the ratio of long-pausing to short-pausing erythrocytes was calculated...
April 5, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28389675/deformation-of-the-lamina-cribrosa-and-optic-nerve-due-to-changes-in-cerebrospinal-fluid-pressure
#12
Andrew J Feola, Baptiste Coudrillier, John Mulvihill, Diogo M Geraldes, Nghia T Vo, Julie Albon, Richard L Abel, Brian C Samuels, C Ross Ethier
Purpose: Cerebrospinal fluid pressure (CSFp) changes are involved or implicated in various ocular conditions including glaucoma, idiopathic intracranial hypertension, and visual impairment and intracranial pressure syndrome. However, little is known about the effects of CSFp on lamina cribrosa and retrolaminar neural tissue (RLNT) biomechanics, potentially important in these conditions. Our goal was to use an experimental approach to visualize and quantify the deformation of these tissues as CSFp increased...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28387019/plasma-n-terminal-probrain-natriuretic-peptide-vascular-endothelial-growth-factor-and-cardiac-troponin-i-as-novel-biomarkers-of-hypertensive-disease-and-target-organ-damage-in-cats
#13
E S Bijsmans, R E Jepson, C Wheeler, H M Syme, J Elliott
BACKGROUND: In the absence of ocular target organ damage (ocular-TOD), diagnosis of hypertension is challenging in cats. Biomarkers would provide additional support for the diagnosis of hypertension. HYPOTHESIS: Vascular endothelial growth factor (VEGF), N-terminal probrain natriuretic peptide (NT-proBNP), cardiac troponin I (cTnI), and urine protein-to-creatinine ratio (UPC) are predictors of systemic hypertension, will be increased in cats with hypertension with or without ocular-TOD, and will decrease with antihypertensive treatment...
April 7, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28379653/factors-related-to-prostaglandin-associated-periorbitopathy-in-glaucoma-patients
#14
Chanikarn Patradul, Visanee Tantisevi, Anita Manassakorn
PURPOSE: To determine factors related to prostaglandin-associated periorbitopathy (PAP) and its prevalence in glaucoma or ocular hypertension (OHT) patients using prostaglandins analogs (PGAs). DESIGN: A cross-sectional study. METHODS: A study of glaucoma or OHT patients, using topical PGAs for at least 3 months, was performed. Eyes treated with PGAs were photoraphed and independently evaluated for PAP by 2 glaucoma specialists using at least 4 out of 7 clinical appearances...
March 29, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28371482/additive-effects-and-safety-of-fixed-combination-therapy-with-1-brinzolamide-and-0-5-timolol-versus-1-dorzolamide-and-0-5-timolol-in-prostaglandin-treated-glaucoma-patients
#15
Makoto Aihara, Misato Adachi, Hiroshi Matsuo, Tetsuya Togano, Takeo Fukuchi, Noriyuki Sasaki
PURPOSE: To compare the additive effects and safety of 1% brinzolamide/0.5% timolol fixed combination (BTFC) versus the low-dose regimen of 1% dorzolamide/0.5% timolol fixed combination (DTFC) in patients with open-angle glaucoma and ocular hypertension (OAG/OH) following treatment with prostaglandin analogues (PGAs). METHODS: A prospective, randomized, double-masked, multicentre, parallel-group and active-controlled study included 201 Japanese OAG/OH patients who had been treated with PGA...
April 3, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28366370/comparison-of-prednisolone-acetate-1-0-and-difluprednate-ophthalmic-emulsion-0-05-after-cataract-surgery-incidence-of-postoperative-steroid-induced-ocular-hypertension
#16
Marius A Tijunelis, Erica Person, Leslie M Niziol, David C Musch, Paul Ernest, Madeline McBain, Shahzad I Mian
PURPOSE: To compare intraocular pressure (IOP) outcomes between 2 common, commercially available corticosteroid drops: difluprednate ophthalmic emulsion 0.05% and prednisolone acetate 1.0%. SETTING: TLC Eyecare and Laser Centers, Jackson, Michigan, USA. DESIGN: Retrospective chart review. METHODS: The outcomes of consecutive patients who had uneventful cataract surgery from April 2013 to September 2013 and used prednisolone acetate postoperatively were compared with the outcomes of consecutive patients who had uneventful cataract surgery from June 2014 to October 2014 and used difluprednate postoperatively...
February 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28358962/vegf-as-a-paracrine-regulator-of-conventional-outflow-facility
#17
Ester Reina-Torres, Joanne C Wen, Katy C Liu, Guorong Li, Joseph M Sherwood, Jason Y H Chang, Pratap Challa, Cassandra M Flügel-Koch, W Daniel Stamer, R Rand Allingham, Darryl R Overby
Purpose: Vascular endothelial growth factor (VEGF) regulates microvascular endothelial permeability, and the permeability of Schlemm's canal (SC) endothelium influences conventional aqueous humor outflow. We hypothesize that VEGF signaling regulates outflow facility. Methods: We measured outflow facility (C) in enucleated mouse eyes perfused with VEGF-A164a, VEGF-A165b, VEGF-D, or inhibitors to VEGF receptor 2 (VEGFR-2). We monitored VEGF-A secretion from human trabecular meshwork (TM) cells by ELISA after 24 hours of static culture or cyclic stretch...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28358961/intravitreal-anti-vegf-injections-reduce-aqueous-outflow-facility-in-patients-with-neovascular-age-related-macular-degeneration
#18
Joanne C Wen, Ester Reina-Torres, Joseph M Sherwood, Pratap Challa, Katy C Liu, Guorong Li, Jason Y H Chang, Scott W Cousins, Stefanie G Schuman, Priyatham S Mettu, W Daniel Stamer, Darryl R Overby, R Rand Allingham
Purpose: We assess the effect of intravitreal anti-VEGF injections on tonographic outflow facility. Methods: Patients with age-related macular degeneration who had received unilateral intravitreal anti-VEGF injections were recruited into two groups, those with ≤10 and those with ≥20 total anti-VEGF injections. Intraocular pressure and tonographic outflow facility of injected and uninjected fellow eyes were measured and compared between groups. Risk factors for development of reduced outflow facility also were assessed...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28356087/evaluation-of-ocular-pulse-amplitude-in-non-arteritic-anterior-ischaemic-optic-neuropathy
#19
Durgul Acan, Omer Karti, Tuncay Kusbeci
BACKGROUND: To evaluate the ocular pulse amplitude (OPA) in patients with chronic non-arteritic anterior ischaemic optic neuropathy (NAION). METHODS: This cross-sectional study comprised a study group of 30 eyes from 30 patients with NAION and a control group of 31 eyes from 31 age and gender-matched healthy subjects. Bilateral OPA was measured with dynamic contour tonometry (DCT) and was compared between the study and control groups. RESULTS: No statistically significant difference was found between the study and control groups in terms of hypertension, diabetes mellitus, ischaemic heart disease and hyperlipidemia...
March 29, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28352076/interaction-of-cochlin-and-mechanosensitive-channel-trek-1-in-trabecular-meshwork-cells-influences-the-regulation-of-intraocular-pressure
#20
Teresia A Carreon, Aida Castellanos, Xavier Gasull, Sanjoy K Bhattacharya
This work was funded by National Institute of Health Grants R01 EY016112, EY015266, and EY014801 and an unrestricted grant to the University of Miami's Bascom Palmer Eye Institute from Research to Prevent Blindness. Financial support from Fight for Sight is gratefully acknowledged. Funding to XG was provided by Instituto de Salud Carlos III, Spain (FIS PI14/00141 and RETIC RD12/0034/0003) and Generalitat de Catalunya (2014SGR1165). In the eye, intraocular pressure (IOP) is tightly regulated and its persistent increase leads to ocular hypertension and glaucoma...
March 28, 2017: Scientific Reports
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