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Three-dimensional printing of biological tissue

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https://www.readbyqxmd.com/read/29791363/design-of-a-portable-phantom-device-to-simulate-tissue-oxygenation-and-blood-perfusion
#1
Xiang Lv, Hongyu Chen, Guangli Liu, Shuwei Shen, Qiang Wu, Chuanzhen Hu, Jialuo Li, Erbao Dong, Ronald X Xu
We propose a portable phantom system for calibration and validation of medical optical devices in a clinical setting. The phantom system comprises a perfusion module and an exchangeable tissue-simulating phantom that simulates tissue oxygenation and blood perfusion. The perfusion module consists of a peristaltic pump, two liquid storage units, and two pressure suppressors. The tissue-simulating phantom is fabricated by a three-dimensional (3D) printing process with microchannels embedded to simulate blood vessels...
May 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29781218/fabrication-of-single-gel-with-different-mechanical-stiffness-using-three-dimensional-mold
#2
Gulsan Ara Sathi Kazi, Kazi Anisur Rahman, Mahmoud Farahat, Takuya Matsumoto
The hydrogel is considering as functional substrates for three-dimensional (3D) environment mimicking the native tissue in vitro. To get the cell or tissue culture result in different stiffness, researchers are used separate gel at the different time. Sometimes these results are manipulated by surrounding environment. To overcome this, we prepared a single hydrogel with different young modulus using a 3D printed mold and cell culture and tissue culture was performed to check the functional capacity. In this proposed device we successfully produced a multi properties agarose hydrogel on a single platform...
May 20, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29768120/three-dimensionally-printed-pearl-powder-poly-caprolactone-composite-scaffolds-for-bone-regeneration
#3
Xu Zhang, Xiaoyu Du, Dejian Li, Rongguang Ao, Bin Yu, Baoqing Yu
Pearl has great potential as a natural biomaterial for bone tissue engineering, but it suffers from low porosity, difficulty in molding, and poor anti-buckling property. In this study, we used the 3-D printing technique to fabricate original pearl powder and PCL composite scaffolds with different concentrations of pearl powder. The four groups of scaffolds were termed PCL, 30% Pearl/PCL, 50% Pearl/PCL and 80% Pearl/PCL scaffolds according to the proportion of pearl powder. The samples were systematically investigated by scanning electron microscopy (SEM), wide-angle XRD, liquid substitution, Zwick static materials testing, and energy dispersive X-ray analysis...
May 16, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29755850/three-dimensional-printing-and-cell-therapy-for-wound-repair
#4
REVIEW
Sylvia van Kogelenberg, Zhilian Yue, Jeremy N Dinoro, Christopher S Baker, Gordon G Wallace
Significance: Skin tissue damage is a major challenge and a burden on healthcare systems, from burns and other trauma to diabetes and vascular disease. Although the biological complexities are relatively well understood, appropriate repair mechanisms are scarce. Three-dimensional bioprinting is a layer-based approach to regenerative medicine, whereby cells and cell-based materials can be dispensed in fine spatial arrangements to mimic native tissue. Recent Advances: Various bioprinting techniques have been employed in wound repair-based skin tissue engineering, from laser-induced forward transfer to extrusion-based methods, and with the investigation of the benefits and shortcomings of each, with emphasis on biological compatibility and cell proliferation, migration, and vitality...
May 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29755838/application-of-laser-scanning-confocal-microscopy-in-the-soft-tissue-exquisite-structure-for-3d-scan
#5
REVIEW
Zhaoqiang Zhang, Mohamed Ibrahim, Yang Fu, Xujia Wu, Fei Ren, Lei Chen
Three-dimensional (3D) printing is a new developing technology for printing individualized materials swiftly and precisely in the field of biological medicine (especially tissue-engineered materials). Prior to printing, it is necessary to scan the structure of the natural biological tissue, then construct the 3D printing digital model through optimizing the scanned data. By searching the literatures, magazines at home and abroad, this article reviewed the current status, main processes and matters needing attention of confocal laser scanning microscope (LSCM) in the application of soft tissue fine structure 3D scanning, empathizing the significance of LSCM in this field...
2018: International Journal of Burns and Trauma
https://www.readbyqxmd.com/read/29717804/three-dimensional-printed-polycaprolactone-microcrystalline-cellulose-scaffolds
#6
Maria Elena Alemán-Domínguez, Elena Giusto, Zaida Ortega, Maryam Tamaddon, Antonio Nizardo Benítez, Chaozong Liu
Microcrystalline cellulose (MCC) is proposed in this study as an additive in polycaprolactone (PCL) matrices to obtain three-dimensional (3D) printed scaffolds with improved mechanical and biological properties. Improving the mechanical behavior and the biological performance of polycaprolactone-based scaffolds allows to increase the potential of these structures for bone tissue engineering. Different groups of samples were evaluated in order to analyze the effect of the additive in the properties of the PCL matrix...
May 2, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29709846/osteogenesis-of-3d-printed-porous-ti6al4v-implants-with-different-pore-sizes
#7
Qichun Ran, Weihu Yang, Yan Hu, Xinkun Shen, Yonglin Yu, Yang Xiang, Kaiyong Cai
Selective laser melting (SLM) is one of the three-dimensional (3D) printing techniques that manufacturing versatile porous scaffolds with precise architectures for potential orthopedic application. To understand how the pore sizes of porous Ti6Al4V scaffolds affect their biological performances, we designed and fabricated porous Ti6Al4V implants with straightforward pore dimensions (500, 700, and 900 µm) via SLM, termed as p500, p700, and p900 respectively. The morphological characteristics of Ti6Al4V scaffolds were assessed showing that the actual pore sizes of these scaffolds were 401 ± 26 µm, 607 ± 24 µm, 801 ± 33 µm, respectively...
April 18, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29708246/development-of-non-orthogonal-3d-printed-scaffolds-to-enhance-their-osteogenic-performance
#8
Diana R Fonseca, Rita Sobreiro-Almeida, Paula C Sol, Nuno M Neves
Three-dimensional (3D)-printed polycaprolactone (PCL)-based scaffolds have been extensively proposed for Tissue Engineering (TE) applications. Currently, the majority of the scaffolds produced are not representative of the complex arrangement of natural structures, since the internal morphologies follow an orthogonal and regular pattern. In order to produce scaffolds that more closely replicate the structure of the extracellular matrix (ECM) of tissues, herein both circular and sinusoidal scaffolds were fabricated and compared to their conventional orthogonal counterparts...
April 30, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29693652/precisely-printable-and-biocompatible-silk-fibroin-bioink-for-digital-light-processing-3d-printing
#9
Soon Hee Kim, Yeung Kyu Yeon, Jung Min Lee, Janet Ren Chao, Young Jin Lee, Ye Been Seo, Md Tipu Sultan, Ok Joo Lee, Ji Seung Lee, Sung-Il Yoon, In-Sun Hong, Gilson Khang, Sang Jin Lee, James J Yoo, Chan Hum Park
Although three-dimensional (3D) bioprinting technology has gained much attention in the field of tissue engineering, there are still several significant engineering challenges to overcome, including lack of bioink with biocompatibility and printability. Here, we show a bioink created from silk fibroin (SF) for digital light processing (DLP) 3D bioprinting in tissue engineering applications. The SF-based bioink (Sil-MA) was produced by a methacrylation process using glycidyl methacrylate (GMA) during the fabrication of SF solution...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29693552/bio-resin-for-high-resolution-lithography-based-biofabrication-of-complex-cell-laden-constructs
#10
Khoon Lim, Riccardo Levato, Pedro F Costa, Miguel Castilho, Cesar R Alcala-Orozco, Kim M A van Dorenmalen, Ferry P W Melchels, Debby Gawlitta, Gary J Hooper, Jos Malda, Tim B F Woodfield
Lithography-based three-dimensional (3D) printing technologies allow high spatial resolution that exceeds that of typical extrusion-based bioprinting approaches, allowing to better mimic the complex architecture of biological tissues. Additionally, lithographic printing via digital light processing (DLP) enables fabrication of free-form lattice and patterned structures which cannot be easily produced with other 3D printing approaches. While significant progress has been dedicated to the development of cell-laden bioinks for extrusion-based bioprinting, less attention has been directed towards the development of cyto-compatible bioresins and their application in lithography-based biofabrication, limiting the advancement of this promising technology...
April 25, 2018: Biofabrication
https://www.readbyqxmd.com/read/29601901/3d-printing-porosity-a-new-approach-to-creating-elevated-porosity-materials-and-structures
#11
A E Jakus, N R Geisendorfer, P L Lewis, R N Shah
We introduce a new process that enables the ability to 3D-print high porosity materials and structures by combining the newly introduced 3D-Painting process with traditional salt-leaching. The synthesis and resulting properties of three 3D-printable inks comprised of varying volume ratios (25:75, 50:50, 70:30) of CuSO4 salt and polylactide-co-glycolide (PLGA), as well as their as-printed and salt-leached counterparts, are discussed. The resulting materials are comprised entirely of PLGA (F-PLGA), but exhibit porosities proportional to the original CuSO4 content...
March 27, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29561794/microfabrication-based-three-dimensional-3-d-extracellular-matrix-microenvironments-for-cancer-and-other-diseases
#12
REVIEW
Kena Song, Zirui Wang, Ruchuan Liu, Guo Chen, Liyu Liu
Exploring the complicated development of tumors and metastases needs a deep understanding of the physical and biological interactions between cancer cells and their surrounding microenvironments. One of the major challenges is the ability to mimic the complex 3-D tissue microenvironment that particularly influences cell proliferation, migration, invasion, and apoptosis in relation to the extracellular matrix (ECM). Traditional cell culture is unable to create 3-D cell scaffolds resembling tissue complexity and functions, and, in the past, many efforts were made to realize the goal of obtaining cell clusters in hydrogels...
March 21, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29519434/3d-printed-biphasic-calcium-phosphate-scaffolds-coated-with-an-oxygen-generating-system-for-enhancing-engineered-tissue-survival
#13
Maria Touri, Fathollah Moztarzadeh, Noor Azuan Abu Osman, Mohammad Mehdi Dehghan, Masoud Mozafari
Tissue engineering scaffolds with oxygen generating elements have shown to be able to increase the level of oxygen and cell survivability in specific conditions. In this study, biphasic calcium phosphate (BCP) scaffolds with the composition of 60% hydroxyapatite (HA) and 40% beta-tricalcium phosphate (β-TCP), which have shown a great potential for bone tissue engineering applications, were fabricated by a direct-write assembly (robocasting) technique. Then, the three-dimensional (3D)-printed scaffolds were coated with different ratios of an oxygen releasing agent, calcium peroxide (CPO), which encapsulated within a polycaprolactone (PCL) matrix through dip-coating, and used for in situ production of oxygen in the implanted sites...
March 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29412939/fast-and-sensitive-near-infrared-fluorescent-probes-for-alp-detection-and-3d-printed-calcium-phosphate-scaffold-imaging-in-vivo
#14
Chul Soon Park, Tai Hwan Ha, Moonil Kim, Naren Raja, Hui-Suk Yun, Mi Jeong Sung, Oh Seok Kwon, Hyeonseok Yoon, Chang-Soo Lee
Alkaline phosphatase (ALP) is a critical biological marker for osteoblast activity during early osteoblast differentiation, but few biologically compatible methods are available for its detection. Here, we describe the discovery of highly sensitive and rapidly responsive novel near-infrared (NIR) fluorescent probes (NIR-Phos-1, NIR-Phos-2) for the fluorescent detection of ALP. ALP cleaves the phosphate group from the NIR skeleton and substantially alters its photophysical properties, therefore generating a large "turn-on" fluorescent signal resulted from the catalytic hydrolysis on fluorogenic moiety...
May 15, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29317370/3d-printed-gelatin-scaffolds-of-differing-pore-geometry-modulate-hepatocyte-function-and-gene-expression
#15
Phillip L Lewis, Richard M Green, Ramille N Shah
Three dimensional (3D) printing is highly amenable to the fabrication of tissue-engineered organs of a repetitive microstructure such as the liver. The creation of uniform and geometrically repetitive tissue scaffolds can also allow for the control over cellular aggregation and nutrient diffusion. However, the effect of differing geometries, while controlling for pore size, has yet to be investigated in the context of hepatocyte function. In this study, we show the ability to precisely control pore geometry of 3D-printed gelatin scaffolds...
March 15, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29208279/collagen-alginate-as-bioink-for-three-dimensional-3d-cell-printing-based-cartilage-tissue-engineering
#16
Xingchen Yang, Zhenhui Lu, Huayu Wu, Wei Li, Li Zheng, Jinmin Zhao
Articular cartilage repair is still a huge challenge for researchers and clinicians. 3D bioprinting could be an innovative technology for cartilage tissue engineering. In this study, we used collagen type I (COL) or agarose (AG) mixed with sodium alginate (SA) to serve as 3D bioprinting bioinks and incorporated chondrocytes to construct in vitro 3D printed cartilage tissue. Swelling ratio, mechanical properties, scanning electron microscopy (SEM), cell viability and cytoskeleton, biochemistry analysis and quantitative real-time polymerase chain reaction (qRT-PCR) were performed to investigate the function of different bioinks in 3D printing cartilage tissue engineering applications...
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29197301/dispensing-based-bioprinting-of-mechanically-functional-hybrid-scaffolds-with-vessel-like-channels-for-tissue-engineering-applications-a-brief-review
#17
REVIEW
Saman Naghieh, Md Sarker, Mohammad Izadifar, Xiongbiao Chen
Over the past decades, significant progress has been achieved in the field of tissue engineering (TE) to restore/repair damaged tissues or organs and, in this regard, scaffolds made from biomaterials have played a critical role. Notably, recent advances in biomaterials and three-dimensional (3D) printing have enabled the manipulation of two or more biomaterials of distinct, yet complementary, mechanical and/or biological properties to form so-called hybrid scaffolds mimicking native tissues. Among various biomaterials, hydrogels synthesized to incorporate living cells and/or biological molecules have dominated due to their hydrated tissue-like environment...
February 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29147558/discovery-and-design-of-self-assembling-peptides
#18
REVIEW
Shuguang Zhang
Peptides are ubiquitous in nature and useful in many fields, from agriculture as pesticides, in medicine as antibacterial and antifungal drugs founded in the innate immune systems, to medicinal chemistry as hormones. However, the concept of peptides as materials was not recognized until 1990 when a self-assembling peptide as a repeating segment in a yeast protein was serendipitously discovered. Peptide materials are so called because they have bona fide materials property and are made from simple amino acids with well-ordered nanostructures under physiological conditions...
December 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/29134773/design-and-biological-functionality-of-a-novel-hybrid-ti-6al-4v-hydrogel-system-for-reconstruction-of-bone-defects
#19
Alok Kumar, K C Nune, R D K Misra
We have designed a unique injectable bioactive hydrogel comprising of alginate, gelatin, and nanocrystalline hydroxyapatite and loaded with osteoblasts, with the ability to infiltrate into three-dimensional Ti-6Al-4V scaffolds with interconnected porous architecture, fabricated by electron beam melting. A two-step crosslinking process using the EDC/NHS and CaCl2 was adopted and found to be effective in the fabrication of cell-loaded hydrogel/Ti-6Al-4V scaffold system. This hybrid Ti-6Al-4V scaffold/hydrogel system was designed for the reconstruction of bone defects, which are difficult to heal in the absence of suitable support materials...
November 14, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29119674/assessment-of-hydrogels-for-bioprinting-of-endothelial-cells
#20
Leo Benning, Ludwig Gutzweiler, Kevin Tröndle, Julian Riba, Roland Zengerle, Peter Koltay, Stefan Zimmermann, G Björn Stark, Günter Finkenzeller
In tissue engineering applications, vascularization can be accomplished by coimplantation of tissue forming cells and endothelial cells (ECs), whereby the latter are able to form functional blood vessels. The use of three-dimensional (3D) bioprinting technologies has the potential to improve the classical tissue engineering approach because these will allow the generation of scaffolds with high spatial control of endothelial cell allocation. This study focuses on a side by side comparison of popular commercially available bioprinting hydrogels (Matrigel, fibrin, collagen, gelatin, agarose, Pluronic F-127, alginate, and alginate/gelatin) in the context of their physicochemical parameters, their swelling/degradation characteristics, their biological effects on vasculogenesis-related EC parameters and their printability...
April 2018: Journal of Biomedical Materials Research. Part A
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