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Prosthetic valve options for children

Marina Sousa Gomes, Mariana Guimarães, Nuno Montenegro
BACKGROUND: Changes in the coagulation system during pregnancy and puerperium produce a physiological hypercoagulable state. These changes are thought to be the cause of the higher rates of deep vein thrombosis (DVT), pulmonary embolism (PE), stroke, and mechanical prosthetic valve thrombosis (PVT) during pregnancy. Thrombolysis can be a treatment option in this case. However, there are no available data from randomized controlled trials in pregnant patients and information about the security of thrombolytics in pregnancy is missing...
February 11, 2018: Journal of Maternal-fetal & Neonatal Medicine
Alessandro Frigiola, Francesca Romana Pluchinotta, Antonio Saracino, Alessandro Giamberti, Carmelo Arcidiacono, Luciane Piazza, Matteo Reali, Gianfranco Butera, Alessandro Varrica, Mario Carminati
AIMS: Paediatric patients with mitral valve (MV) disease have limited options for prosthetic MV replacement. Based on long experience with the stented bovine jugular vein graft (Melody valve) in the right ventricular outflow tract, we aimed to test the use of the Melody valve as a surgical implant in the mitral position in a small group of infants with congenital mitral disease. METHODS AND RESULTS: Eight patients, aged from 3 months to 6.2 years, with congenital MV dysplasia underwent Melody valve implantation in the mitral position between March 2014 and October 2015...
April 20, 2017: EuroIntervention
Sharan Ramaswamy, Makensley Lordeus, Omkar V Mankame, Lilliam Valdes-Cruz, Steven Bibevski, Sarah M Bell, Ivan Baez, Frank Scholl
Infants and children born with severe cardiac valve lesions have no effective long term treatment options since currently available tissue or mechanical prosthetic valves have sizing limitations and no avenue to accommodate the growth of the pediatric patient. Tissue engineered heart valves (TEHVs) which could provide for growth, self-repair, infection resistance, and long-term replacement could be an ideal solution. Porcine small intestinal submucosa (PSIS) has recently emerged as a potentially attractive bioscaffold for TEHVs...
March 2017: Cardiovascular Engineering and Technology
Aleksander Sizarov, Younes Boudjemline
Correction of malformations affecting the right ventricular outflow tract often results in residual abnormalities that require valve implantation at a later stage to prevent right ventricular deterioration. In the paediatric population, the pathology of congenital valve stenosis or insufficiency is often complex, options for surgical repair are limited, and valve replacement remains the only-albeit unattractive-alternative. Prosthetic heart valve implantation can be performed either surgically or, nowadays, percutaneously...
May 2016: Archives of Cardiovascular Diseases
Kazuki Morimoto, Takaya Hoashi, Koji Kagisaki, Jun Yoshimatsu, Isao Shiraishi, Hajime Ichikawa, Junjiro Kobayashi, Takeshi Nakatani, Toshikatsu Yagihara, Soichiro Kitamura, Tomoyuki Fujita
BACKGROUND: The most appropriate valve substitute at aortic valve replacement (AVR) for young female adult patients wanting to have children is unclear. METHODS AND RESULTS: Between 1992 and 2013, 12 consecutive female patients aged >18 (median, 22.5 years; range, 18-34 years) underwent Ross operation (Ross group). Between 1984 and 2013, 9 consecutive female patients aged >18 (median, 30 years; range, 22-39 years) underwent AVR with bioprosthesis (bioprosthesis group)...
2015: Circulation Journal: Official Journal of the Japanese Circulation Society
Sarah A Schubert, John L Myers, Allen R Kunselman, Joseph B Clark
BACKGROUND: Bovine pericardial valves are often used for pulmonary valve replacement (PVR) in patients with previously repaired congenital heart disease. Attention has recently focused on the safety of the Mitroflow (Sorin Group USA, Arvada, CO) bovine pericardial valve after a national alert describing several cases of sudden valve failure in young patients. In response, we reviewed our experience using the Mitroflow bioprosthesis for PVR. METHODS: Medical records were reviewed for all patients who underwent PVR using a Mitroflow valve at our center (2008-2013)...
May 2015: Annals of Thoracic Surgery
Ajit P Yoganathan, Mark Fogel, Susan Gamble, Michael Morton, Paul Schmidt, Jeff Secunda, Sara Vidmar, Pedro Del Nido
OBJECTIVE: Congenital heart valve disease is one of the most common abnormalities in children. There are limited technological solutions available for treating children with congenital heart valve diseases. The aim of this study is to provide the details of the consensus reached in terms of pediatric definitions, design approach, in vitro testing, and clinical trials, which may be used as guidance for developing prosthetic heart valves for the pediatric indication. METHODS: In stark contrast to the various designs of adult-sized replacement valves available in the market, there are no Food and Drug Administration (FDA)-approved prosthetic heart valves available for use in the pediatric population...
October 2013: Journal of Thoracic and Cardiovascular Surgery
David L S Morales, Brandi E Braud, Daniel J DiBardino, Kathleen E Carberry, E Dean McKenzie, Jeffrey S Heinle, Charles D Fraser
OBJECTIVE: No ideal option exists for restoring pulmonary valve competence late after repair of the congenitally abnormal right ventricular outflow tract (RVOT). This has driven a continued search for new alternatives. Texas Children's Hospital has recently used the Carpentier-Edwards Perimount RSR Pericardial Aortic Prosthesis (Edwards Lifesciences, Irvine, Calif, USA) for this indication and reports the initial experience. DESIGN: Retrospective chart review. SETTING: Academically affiliated tertiary-care pediatric hospital...
March 2007: Congenital Heart Disease
J M Herreros, S Mastrobuoni, M Ubilla, G Rábago, M Lorente Ruiz, J Rifón, M Hernández
The advances in the manipulation of human tissues, the development of cryobiology, paediatric cardiac surgery, the impossibility of obtaining an ideal prosthetic cardiac valve and the surgical treatment of cardiovascular infections have revived interest in the use of homografts. The donors of these homografts can be: a) Live donors: aortic and pulmonary valve of the recipient of a heart transplant; b) Multiorgan donors with a diagnosis of death according to neurological criteria, whose heart is rejected for heart transplant; c) Cadaver donors with asystolia of less than 8 hours...
2006: Anales del Sistema Sanitario de Navarra
Ganesh Shanmugam, Kenneth MacArthur, James Pollock
BACKGROUND AND AIM OF THE STUDY: Early and late outcomes following mechanical aortic valve replacement (AVR) in children were analyzed. METHODS: Between January 1980 and December 2003, 55 patients underwent mechanical AVR at the authors' institution. Of these patients, 12 had aortic regurgitation (AR), 31 had aortic stenosis (AS), and 12 had mixed disease. Preoperatively, 25 patients (45.5%) were in NYHA classes III and IV. Among patients, 22 had a previous valvotomy and 19 had associated cardiac defects...
March 2005: Journal of Heart Valve Disease
Eldad Erez, Kirk R Kanter, Vincent K H Tam, Willis H Williams
BACKGROUND: In children with complex multilevel left ventricular outflow tract obstruction (LVOTO), the Konno aortoventriculoplasty is used to enlarge the aortic root and increase the size of the aortic valve implanted. We present our experience with the evolution of this surgical approach from prosthetic valves to the Ross operation. METHODS: Between March 1982 and July 2000, 60 patients (36 males and 24 females) had 72 Konno aortoventriculoplasties (prosthetic valve and Konno group [57 patients; redo, 12] and Ross-Konno group [15 patients])...
July 2002: Annals of Thoracic Surgery
Bradley S. Marino, Nancy D. Bridges, Stephen M. Paridon
The goals of surgery in children with chronic aortic insufficiency are to prevent irreversible left ventricular dysfunction and to provide for long-term survival. In the past, surgical options included placement of a mechanical valve, a porcine bioprosthesis, or an aortic valve homograft. Complications from these options include thromboembolism, prosthetic valve endocarditis, limited durability, and lack of growth potential. The increasing utilization of the Ross procedure to treat chronic aortic insufficiency has led to new interest in the question of when to operate on a regurgitant aortic valve...
1998: Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual
E Erez, V K Tam, W H Williams, K R Kanter
OBJECTIVE: To evaluate the outcome of aortic root augmentation by the Konno-aortoventriculoplasty technique as part of reoperative aortic valve replacement. METHODS: Since 1983, 15 patients, 12 males and three females, had repeat aortic valve replacement (AVR) with concomitant Konno aortoventriculoplasty. Age ranged from 1.2 to 18 years (mean 12.5 years). The underlying anatomic diagnoses were valve and subvalvar aortic stenosis in 11, truncal valve insufficiency in one, endocarditis in one, Shone's complex in one and severe aortic insufficiency associated with a ventricular septal defect in one patient...
June 2001: European Journal of Cardio-thoracic Surgery
D Bolz, T Kühne, R Jivraj, J Hammer
Prosthetic heart valve thrombosis is associated with a high mortality. Traditionally, thrombectomy or valve replacement is performed. Thrombolysis offers a promising alternative to surgery. Usually, streptokinase and urokinase are the preferred agents for thrombolysis; however, human recombinant tissue plasminogen activator (rt-PA) is increasingly used. Thrombosis of prosthetic valves in children and adolescents is rare and experience of thrombolysis for obstructed valves is limited. We report the successful lysis of a thrombosed prosthetic tricuspid valve in an adolescent using rt-PA...
July 2000: Pediatric Cardiology
E Sharoni, J Katz, O Dagan, A Lorber, R Hirsch, L C Blieden, B A Vidne, E Birk
BACKGROUND: The need for aortic valve replacement in children and young adults poses a special problem to cardiologists and surgeons. Replacing the sick aortic valve with the patient's pulmonary valve as described by Ross has proven to be a good option in this special age group. OBJECTIVE: To review our initial experience in order to assess the short-term results. METHODS: From January 1996 to June 1999, 40 patients (age 8 months to 41 years) underwent aortic valve replacement with pulmonary autograft...
February 2000: Israel Medical Association Journal: IMAJ
C Alexiou, A McDonald, S M Langley, M J Dalrymple-Hay, M P Haw, J L Monro
OBJECTIVE: The choice of the most appropriate substitute in children with irreparable aortic valve lesions remains controversial. The aim of this study was to assess early and late outcomes following aortic valve replacement (AVR) with mechanical prostheses in children. PATIENTS: Fifty-six patients (42 male, 14 female, mean age 11.2, range 1-16 years) undergoing AVR with mechanical prostheses between October 1972 and January 1999 were evaluated. Thirty-six patients (64...
February 2000: European Journal of Cardio-thoracic Surgery
I Adatia, P M Moore, R A Jonas, S D Colan, J E Lock, J F Keane
OBJECTIVES: We report the clinical course and unique hemodynamic findings after placement of a supraannular mitral valve prosthesis. BACKGROUND: Children with symptomatic mitral valve disease whose annulus is too small for the smallest prosthesis are difficult to manage. One option is valve replacement with a prosthesis positioned entirely within the left atrium (LA). METHODS: We reviewed 17 patients (median age 10 months) with symptomatic mitral valve disease who underwent placement of a supraannular valve prosthesis between 1980 and 1994...
April 1997: Journal of the American College of Cardiology
R H Anderson, M Lal, S Y Ho
BACKGROUND AND AIMS OF THE STUDY: The aortic root is a frequent site of surgical intervention, both in adults and children, yet there is ambiguity about the precise nature and relation of the various structures composing the aortic root. The present review aims to clarify these ambiguities and to explain the morphological basis of surgical procedures for enlargement of the aortic root. MATERIALS AND METHODS: Using autopsied specimens of normal hearts, the morphology of the attachment of the leaflets, the interleaflet triangles and the circular ventriculo-arterial junction of the aortic root were studied in detail, paying special regard to fibrous and muscular continuity, relation to the atrioventricular conduction axis, and the coronary arterial branching...
November 1996: Journal of Heart Valve Disease
J Ninet, F Sassolas, J Robin, S Di Fillipo, A Bozio, G Champsaur
The authors report their experience of mitral valve replacement in infants under 2 years of age. A St Jude medical mitral prosthesis was implanted in 8 children, 7 with mitral regurgitation and 1 with mitral stenosis. The average age at surgery was 9 months with an average body weight of 6.6 Kg. Two children had prior mitral valvuloplasty. All patients were in the NYHA functional Class IV. One patient died after surgery (12.5%). There was one secondary death during follow-up. Six children were followed up for an average of 61 months (range 34 to 104 months)...
May 1994: Archives des Maladies du Coeur et des Vaisseaux
M Citak, A Rees, C Mavroudis
Infective endocarditis occurs infrequently in the general pediatric population, occurring mostly in patients with congenital heart disease. This study reviews our surgical experience with infective endocarditis based on a policy of aggressive intervention, conservative operative debridement, and creative reconstruction options using pericardium and prosthetic heart valves. From 1982 to 1989, 16 patients, 3 weeks to 16 years of age, underwent 19 intracardiac operations for infective endocarditis therapy at Kosair Children's Hospital...
October 1992: Annals of Thoracic Surgery
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