keyword
https://read.qxmd.com/read/38536529/pioneering-electrochemical-detection-unveils-erdafitinib-a-breakthrough-in-anticancer-agent-determination
#21
JOURNAL ARTICLE
Merve Hatun Yildir, Asena Ayse Genc, Nevin Erk, Wiem Bouali, Nesrin Bugday, Sedat Yasar, Ozgur Duygulu
The successful fabrication is reported of highly crystalline Co nanoparticles interconnected with zeolitic imidazolate framework (ZIF-12) -based amorphous porous carbon using the molten-salt-assisted approach utilizing NaCl. Single crystal diffractometers (XRD), and X-ray photoelectron spectroscopy (XPS) analyses confirm the codoped amorphous carbon structure. Crystallite size was calculated by Scherrer (34 nm) and Williamson-Hall models (42 nm). The magnetic properties of NPCS (N-doped porous carbon sheet) were studied using a vibrating sample magnetometer (VSM)...
March 27, 2024: Mikrochimica Acta
https://read.qxmd.com/read/38536519/social-excluder-s-face-reduces-gaze-triggered-attention-orienting
#22
JOURNAL ARTICLE
Jiajia Yang, Li Zhou, Zhonghua Hu
Social ostracism, a negative affective experience in interpersonal interactions, is thought to modulate the gaze-cueing effect (GCE). However, it is unclear whether the impact of social exclusion on the GCE is related to the identity of the cueing face. Therefore, the present study employed a two-phase paradigm to address this issue. In the first phase, two groups of participants were instructed to complete a Cyberball game with two virtual avatars to establish a binding relationship between a specific face's identity and the emotions of social exclusion or inclusion...
March 27, 2024: Psychological Research
https://read.qxmd.com/read/38536455/matching-proposed-clinical-and-mri-criteria-of-aggressive-multiple-sclerosis-to-serum-and-cerebrospinal-fluid-markers-of-neuroaxonal-and-glial-injury
#23
JOURNAL ARTICLE
Martin A Schaller-Paule, Michelle Maiworm, Jan Hendrik Schäfer, Lucie Friedauer, Elke Hattingen, Katharina Johanna Wenger, Frank Weber, Jasmin Jakob, Falk Steffen, Stefan Bittner, Yavor Yalachkov, Christian Foerch
BACKGROUND: Definitions of aggressive MS employ clinical and MR imaging criteria to identify highly active, rapidly progressing disease courses. However, the degree of overlap between clinical and radiological parameters and biochemical markers of CNS injury is not fully understood. Aim of this cross-sectional study was to match clinical and MR imaging hallmarks of aggressive MS to serum/CSF markers of neuroaxonal and astroglial injury (neurofilament light chain (sNfL, cNfL), and glial fibrillary acidic protein (sGFAP, cGFAP))...
March 27, 2024: Journal of Neurology
https://read.qxmd.com/read/38536454/walking-and-talking-the-plank-dual-task-performance-costs-in-a-virtual-balance-threatening-environment
#24
JOURNAL ARTICLE
Tiphanie E Raffegeau, Sarah A Brinkerhoff, Mindie Clark, Ashlee D McBride, A Mark Williams, Peter C Fino, Bradley Fawver
We evaluated the effects of engaging in extemporaneous speech in healthy young adults while they walked in a virtual environment meant to elicit low or high levels of mobility-related anxiety. We expected that mobility-related anxiety imposed by a simulated balance threat (i.e., virtual elevation) would impair walking behavior and lead to greater dual-task costs. Altogether, 15 adults (age = 25.6 ± 4.7 yrs, 7 women) walked at their self-selected speed within a VR environment that simulated a low (ground) and high elevation (15 m) setting while speaking extemporaneously (dual-task) or not speaking (single-task)...
March 27, 2024: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://read.qxmd.com/read/38536418/imatinib-pharmacokinetics-and-creatine-kinase-levels-in-chronic-myeloid-leukemia-patients-implications-for-therapeutic-response-and-monitoring
#25
JOURNAL ARTICLE
Mervat M Omran, Amel B Ibrahim, Raafat Abdelfattah, Samia A Shouman, Marwa S Hamza
BACKGROUND: Imatinib treatment for certain cancers can lead to elevated creatine kinase (CK) levels, potentially indicating muscle injury, and ongoing research aims to understand the correlation between imatinib levels and creatine kinase to assess its impact on treatment response. METHODS: This single-center observational study involved 76 chronic myeloid leukemia (CML) patients receiving imatinib treatment, focusing on evaluating drug and metabolite levels using liquid chromatography-mass spectrometry (LC-MS-MS) instrumentation...
March 27, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38536229/combinatorial-approach-with-mass-spectrometry-and-lectin-microarray-dissected-site-specific-glycostem-and-glycoleaf-features-of-the-virion-derived-spike-protein-of-ancestral-and-%C3%AE-variant-sars-cov-2-strains
#26
JOURNAL ARTICLE
Takahiro Hiono, Hiroaki Sakaue, Azusa Tomioka, Hiroyuki Kaji, Michihito Sasaki, Yasuko Orba, Hirofumi Sawa, Atsushi Kuno
The coronavirus disease (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has impacted public health globally. As the glycosylation of viral envelope glycoproteins is strongly associated with their immunogenicity, intensive studies have been conducted on the glycans of the glycoprotein of SARS-CoV-2, the spike (S) protein. Here, we conducted intensive glycoproteomic analyses of the SARS-CoV-2 S protein of ancestral and γ-variant strains using a combinatorial approach with two different technologies: mass spectrometry (MS) and lectin microarrays (LMA)...
March 27, 2024: Journal of Proteome Research
https://read.qxmd.com/read/38536225/effectiveness-of-the-minder-mobile-mental-health-and-substance-use-intervention-for-university-students-randomized-controlled-trial
#27
JOURNAL ARTICLE
Melissa Vereschagin, Angel Y Wang, Chris G Richardson, Hui Xie, Richard J Munthali, Kristen L Hudec, Calista Leung, Katharine D Wojcik, Lonna Munro, Priyanka Halli, Ronald C Kessler, Daniel V Vigo
BACKGROUND: University attendance represents a transition period for students that often coincides with the emergence of mental health and substance use challenges. Digital interventions have been identified as a promising means of supporting students due to their scalability, adaptability, and acceptability. Minder is a mental health and substance use mobile app that was codeveloped with university students. OBJECTIVE: This study aims to examine the effectiveness of the Minder mobile app in improving mental health and substance use outcomes in a general population of university students...
March 27, 2024: Journal of Medical Internet Research
https://read.qxmd.com/read/38536220/benchmarking-mental-health-status-using-passive-sensor-data-protocol-for-a-prospective-observational-study
#28
JOURNAL ARTICLE
Robyn E Kilshaw, Abigail Boggins, Olivia Everett, Emma Butner, Feea R Leifker, Brian R W Baucom
BACKGROUND: Computational psychiatry has the potential to advance the diagnosis, mechanistic understanding, and treatment of mental health conditions. Promising results from clinical samples have led to calls to extend these methods to mental health risk assessment in the general public; however, data typically used with clinical samples are neither available nor scalable for research in the general population. Digital phenotyping addresses this by capitalizing on the multimodal and widely available data created by sensors embedded in personal digital devices (eg, smartphones) and is a promising approach to extending computational psychiatry methods to improve mental health risk assessment in the general population...
March 27, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38536204/the-impact-of-a-pandemic-on-a-military-oral-and-maxillofacial-pathology-biopsy-service
#29
JOURNAL ARTICLE
Trevor E Miller, Noel E Dickens, Matthew R Rehmel, Bradley E Jones, Nicholas J Hamlin, Quinn C Robbins
INTRODUCTION: Coronavirus disease 2019 (COVID-19) and the resulting societal reaction presented new challenges to the medical community by limiting patient access to care in 2020 and 2021. The Navy Postgraduate Dental School (NPDS) oral and maxillofacial pathology biopsy service is dependent on in-office physician or dentist appointments and patient biopsies. The purpose of this study was to understand the regulatory and societal impacts of COVID-19 restrictions on biopsy service submissions by assessing NPDS biopsy submission quantities and disease distribution...
March 25, 2024: Military Medicine
https://read.qxmd.com/read/38536179/genetic-and-phenotypic-features-of-schizophrenia-in-the-uk-biobank
#30
JOURNAL ARTICLE
Sophie E Legge, Antonio F Pardiñas, Grace Woolway, Elliott Rees, Alastair G Cardno, Valentina Escott-Price, Peter Holmans, George Kirov, Michael J Owen, Michael C O'Donovan, James T R Walters
IMPORTANCE: Large-scale biobanks provide important opportunities for mental health research, but selection biases raise questions regarding the comparability of individuals with those in clinical research settings. OBJECTIVE: To compare the genetic liability to psychiatric disorders in individuals with schizophrenia in the UK Biobank with individuals in the Psychiatric Genomics Consortium (PGC) and to compare genetic liability and phenotypic features with participants recruited from clinical settings...
March 27, 2024: JAMA Psychiatry
https://read.qxmd.com/read/38536131/brain-abscess-secondary-to-streptococcus-intermedius-following-an-egd-with-biopsy-in-a-patient-with-eosinophilic-esophagitis
#31
JOURNAL ARTICLE
N Begum Ozturk, Tatjana Blazin, Aparna Hariharan, Naveen Reddy
Brain abscess is a rare complication of esophagogastro- duodenoscopy (EGD) with few reported cases in the literature. In this report, we discuss a patient presenting with altered mental status, headache, and dysarthria due to brain abscess caused by S. intermedius shortly after an EGD with an esophageal biopsy showing a new diagnosis of eosinophilic esophagitis. We highlight the rare association of EGD and brain abscess, and discuss the importance of prompt diagnosis and treatment.
April 1, 2024: Rhode Island Medical Journal
https://read.qxmd.com/read/38536130/seizure-as-first-manifestation-of-hemolytic-uremic-syndrome-with-bacteremia-due-to-shiga-toxin-producing-escherichia-coli
#32
JOURNAL ARTICLE
Laura Schwartz, Jeffrey Riese
Hemolytic uremic syndrome (HUS) often causes neurologic symptoms, but they typically occur as a later symptom of the syndrome. In addition, the Shiga toxin- producing E. coli (STEC) which causes HUS rarely causes bacteremia. We present the case of a 10-year-old male with Smith-Magenis syndrome who was admitted to the hospital due to STEC gastroenteritis, who was initially improving with supportive care, and then subsequently developed fever and had multiple seizures which were different from his typical seizure semiology...
April 1, 2024: Rhode Island Medical Journal
https://read.qxmd.com/read/38536107/benchmarking-machine-learning-based-real-time-respiratory-signal-predictors-in-4d-sbrt
#33
JOURNAL ARTICLE
Lukas Wimmert, Maximilian Nielsen, Frederic Madesta, Tobias Gauer, Christian Hofmann, Rene Werner
BACKGROUND: Stereotactic body radiotherapy of thoracic and abdominal tumors has to account for respiratory intrafractional tumor motion. Commonly, an external breathing signal is continuously acquired that serves as a surrogate of the tumor motion and forms the basis of strategies like breathing-guided imaging and gated dose delivery. However, due to inherent system latencies, there exists a temporal lag between the acquired respiratory signal and the system response. Respiratory signal prediction models aim to compensate for the time delays and to improve imaging and dose delivery...
March 27, 2024: Medical Physics
https://read.qxmd.com/read/38536071/-xanthomonas-rydalmerensis-sp-nov-a-non-pathogenic-member-of-group-1-xanthomonas
#34
JOURNAL ARTICLE
Daniel J E McKnight, Johanna Wong-Bajracharya, Efenaide B Okoh, Fridtjof Snijders, Fiona Lidbetter, John Webster, Mathew Haughton, Aaron E Darling, Steven P Djordjevic, Daniel R Bogema, Toni A Chapman
Five bacterial isolates were isolated from Fragaria × ananassa in 1976 in Rydalmere, Australia, during routine biosecurity surveillance. Initially, the results of biochemical characterisation indicated that these isolates represented members of the genus Xanthomonas . To determine their species, further analysis was conducted using both phenotypic and genotypic approaches. Phenotypic analysis involved using MALDI-TOF MS and BIOLOG GEN III microplates, which confirmed that the isolates represented members of the genus Xanthomonas but did not allow them to be classified with respect to species...
March 2024: International Journal of Systematic and Evolutionary Microbiology
https://read.qxmd.com/read/38536052/spirituality-and-people-with-psychosis-a-content-analysis-of-influential-primetime-television-programs
#35
JOURNAL ARTICLE
David R Hodge, Patricia R Turner
OBJECTIVE: This mixed methods study examined depictions of spirituality among people with psychosis in influential television programming. Spirituality is a central strength for many people with psychosis. Yet, despite the important role media plays in shaping perceptions, little research has examined the intersection between spirituality and psychosis in popular media. METHODS: To address this gap, we conducted a content analysis of the 50 most viewed primetime fictional television shows over a 10-year period as determined by the Nielsen rating organization...
March 27, 2024: International Journal of Psychiatry in Medicine
https://read.qxmd.com/read/38536005/identification-of-compounds-that-impact-consumer-flavor-liking-of-american-european-hazelnut-hybrids-using-nontargeted-lc-ms-analysis
#36
JOURNAL ARTICLE
Mengying Fu, Edisson Tello, Emmanuel Hatzakis, Devin G Peterson
American-European ( Corylus americana × Corylus avellana ) hazelnut hybrids are being developed for the Midwest-growing region of the United States. However, an inadequate understanding of the compounds that impact the consumer acceptance of hazelnuts limits breeding programs. Nontargeted liquid chromatography/mass spectrometry (LC/MS) chemical profiles of 12 roasted hybrid hazelnut samples and the corresponding consumer flavor liking scores were modeled by orthogonal partial least squares with good fit and predictive ability ( R 2 Y > 0...
March 27, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38535996/proteomic-analysis-of-human-saliva-via-solid-phase-microextraction-coupled-with-liquid-chromatography-mass-spectrometry
#37
JOURNAL ARTICLE
Runshan W Jiang, Lina M Marin, Karol Jaroch, Wei Zhou, Walter L Siqueira, Janusz Pawliszyn
Proteomics of human saliva samples was achieved for the first time via biocompatible solid-phase microextraction (bio-SPME) devices. Upon introduction of a porogen to a conventional C18 coating, porous C18/polyacrylonitrile (PAN) SPME blades were able to extract peptides up to 3.0 kDa and more peptides than commercial SPME blades. Following Trypsin digestion, salivary proteomic analysis was achieved via SPME-LC-MS/MS. Seven endogenous proteins were consistently identified in all saliva samples via bio-SPME...
March 27, 2024: Analytical Chemistry
https://read.qxmd.com/read/38535992/native-mass-spectrometry-dissects-the-structural-dynamics-of-an-allosteric-heterodimer-of-sars-cov-2-nonstructural-proteins
#38
JOURNAL ARTICLE
Stephanie M Thibert, Deseree J Reid, Jesse W Wilson, Rohith Varikoti, Natalia Maltseva, Katherine J Schultz, Agustin Kruel, Gyorgy Babnigg, Andrzej Joachimiak, Neeraj Kumar, Mowei Zhou
Structure-based drug design, which relies on precise understanding of the target protein and its interaction with the drug candidate, is dramatically expedited by advances in computational methods for candidate prediction. Yet, the accuracy needs to be improved with more structural data from high throughput experiments, which are challenging to generate, especially for dynamic and weak associations. Herein, we applied native mass spectrometry (native MS) to rapidly characterize ligand binding of an allosteric heterodimeric complex of SARS-CoV-2 nonstructural proteins (nsp) nsp10 and nsp16 (nsp10/16), a complex essential for virus survival in the host and thus a desirable drug target...
March 27, 2024: Journal of the American Society for Mass Spectrometry
https://read.qxmd.com/read/38535979/understanding-multiple-sclerosis-as-a-disease-spectrum-above-and-below-the-clinical-threshold
#39
JOURNAL ARTICLE
Stephen Krieger, Karin Cook, Carrie M Hersh
PURPOSE OF REVIEW: Research in multiple sclerosis (MS) has long been predicated on clinical groupings that do not reflect the underlying biologic heterogeneity apparent within patient populations. This review explicates the various levels of explanation through which the spectrum of disease is described and investigated both above and below the clinical threshold of detection, as framed by the topographical model of MS, to help advance a cogent mechanistic framework. RECENT FINDINGS: Contemporary evidence has amended the view of MS as consisting of sequential disease phases in favor of a spectrum of disease with an admixture of interdependent and dynamic pathobiological axes driving tissue injury and progression...
March 28, 2024: Current Opinion in Neurology
https://read.qxmd.com/read/38535966/women-living-with-fibromyalgia-during-the-covid-19-pandemic-a-qualitative-study
#40
JOURNAL ARTICLE
Helena Vall-Roqué, Rubén Nieto, Mayte Serrat, Beatriz Sora, Pau Tolo, Patricia Ureña, Albert Feliu-Soler, Juan V Luciano, Rebeca Pardo
We explored the experiences of women with fibromyalgia during the COVID-19 pandemic from a qualitative approach by interviewing eighteen women. We identified seven main themes after performing a thematic analysis: pain description, pain triggers, impact, coping strategies, treatment for pain, pain onset and general situation. In general, pain worsened during the pandemic, and activity restrictions and changes in social interactions were particularly related with that. Pain negatively impacted different life domains: mental health, physical health, cognitive status, social activities and daily activities...
March 27, 2024: Health Care for Women International
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