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https://www.readbyqxmd.com/read/28241630/spectroscopic-super-resolution-fluorescence-cell-imaging-using-ultra-small-ge-quantum-dots
#1
Mingying Song, Ali Karatutlu, Isma Ali, Osman Ersoy, Yun Zhou, Yongxin Yang, Yuanpeng Zhang, William R Little, Ann P Wheeler, Andrei V Sapelkin
We demonstrate a spectroscopic imaging based super-resolution approach by separating the overlapping diffraction spots into several detectors during a single scanning period and taking advantage of the size-dependent emission wavelength in nanoparticles. This approach has been tested using off-the-shelf quantum dots (Invitrogen Qdot) and in-house novel ultra-small (~3 nm) Ge QDs. Furthermore, we developed a method-specific Gaussian fitting and maximum likelihood estimation based on a Matlab algorithm for fast QD localisation...
February 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28241497/is-gamma-radiation-suitable-to-preserve-phenolic-compounds-and-to-decontaminate-mycotoxins-in-aromatic-plants-a-case-study-with-aloysia-citrodora-pal%C3%A3-u
#2
Eliana Pereira, Lillian Barros, Amilcar L Antonio, Sandra Cabo Verde, Celestino Santos-Buelga, Isabel C F R Ferreira, Paula Rodrigues
This study aimed to determine the effect of gamma radiation on the preservation of phenolic compounds and on decontamination of dry herbs in terms of ochratoxin A (OTA) and aflatoxin B1 (AFB1), using Aloysia citrodora Paláu as a case study. For this purpose, artificially contaminated dry leaves were submitted to gamma radiation at different doses (1, 5, and 10 kGy; at dose rate of 1.7 kGy/h). Phenolic compounds were analysed by HPLC-DAD-ESI/MS and mycotoxin levels were determined by HPLC-fluorescence. Eleven phenolic compounds were identified in the samples and despite the apparent degradation of some compounds (namely verbasoside), 1 and 10 kGy doses point to a preservation of the majority of the compounds...
February 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28241496/the-role-of-sarcosine-uracil-and-kynurenic-acid-metabolism-in-urine-for-diagnosis-and-progression-monitoring-of-prostate-cancer
#3
Georgios Gkotsos, Christina Virgiliou, Ioanna Lagoudaki, Chrysanthi Sardeli, Nikolaos Raikos, Georgios Theodoridis, Georgios Dimitriadis
The aim of this pilot study is to evaluate sarcosine, uracil, and kynurenic acid in urine as potential biomarkers in prostate cancer detection and progression monitoring. Sarcosine, uracil, and kynurenic acid were measured in urine samples of 32 prostate cancer patients prior to radical prostatectomy, 101 patients with increased prostate-specific antigen prior to ultrasonographically-guided prostatic biopsy collected before and after prostatic massage, and 15 healthy volunteers (controls). The results were related to histopathologic data, Gleason score, and PSA (Prostate Specific Antigen)...
February 23, 2017: Metabolites
https://www.readbyqxmd.com/read/28241477/impact-of-exercise-and-aging-on-rat-urine-and-blood-metabolome-an-lc-ms-based-metabolomics-longitudinal-study
#4
Olga Deda, Helen G Gika, Ioannis Taitzoglou, Νikolaos Raikos, Georgios Theodoridis
Aging is an inevitable condition leading to health deterioration and death. Regular physical exercise can moderate the metabolic phenotype changes of aging. However, only a small number of metabolomics-based studies provide data on the effect of exercise along with aging. Here, urine and whole blood samples from Wistar rats were analyzed in a longitudinal study to explore metabolic alterations due to exercise and aging. The study comprised three different programs of exercises, including a life-long protocol which started at the age of 5 months and ended at the age of 21 months...
February 23, 2017: Metabolites
https://www.readbyqxmd.com/read/28241456/evaluation-of-rice-resistance-to-southern-rice-black-streaked-dwarf-virus-and-rice-ragged-stunt-virus-through-combined-field-tests-quantitative-real-time-pcr-and-proteome-analysis
#5
Zhenchao Wang, Lu Yu, Linhong Jin, Wenli Wang, Qi Zhao, Longlu Ran, Xiangyang Li, Zhuo Chen, Rong Guo, Yongtian Wei, Zhongcheng Yang, Enlong Liu, Deyu Hu, Baoan Song
: Diseases caused by southern rice black-streaked dwarf virus (SRBSDV) and rice ragged stunt virus (RRSV) considerably decrease grain yield. Therefore, determining rice cultivars with high resistance to SRBSDV and RRSV is necessary. In this study, rice cultivars with high resistance to SRBSDV and RRSV were evaluated through field trials in Shidian and Mangshi county, Yunnan province, China. SYBR Green I-based quantitative real-time polymerase chain reaction (qRT-PCR) analysis was used to quantitatively detect virus gene expression levels in different rice varieties...
February 22, 2017: Viruses
https://www.readbyqxmd.com/read/28241426/zinc-status-biomarkers-and-cardiometabolic-risk-factors-in-metabolic-syndrome-a-case-control-study
#6
Erika P S Freitas, Aline T O Cunha, Sephora L S Aquino, Lucia F C Pedrosa, Severina C V C Lima, Josivan G Lima, Maria G Almeida, Karine C M Sena-Evangelista
Metabolic syndrome (MS) involves pathophysiological alterations that might compromise zinc status. The aim of this study was to evaluate zinc status biomarkers and their associations with cardiometabolic factors in patients with MS. Our case control study included 88 patients with MS and 37 controls. We performed clinical and anthropometric assessments and obtained lipid, glycemic, and inflammatory profiles. We also evaluated zinc intake, plasma zinc, erythrocyte zinc, and 24-h urinary zinc excretion. The average zinc intake was significantly lower in the MS group (p < 0...
February 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28241423/metabolic-profiling-as-a-screening-tool-for-cytotoxic-compounds-identification-of-3-alkyl-pyridine-alkaloids-from-sponges-collected-at-a-shallow-water-hydrothermal-vent-site-north-of-iceland
#7
Eydis Einarsdottir, Manuela Magnusdottir, Giuseppe Astarita, Matthias Köck, Helga M Ögmundsdottir, Margret Thorsteinsdottir, Hans Tore Rapp, Sesselja Omarsdottir, Giuseppe Paglia
Twenty-eight sponge specimens were collected at a shallow water hydrothermal vent site north of Iceland. Extracts were prepared and tested in vitro for cytotoxic activity, and eight of them were shown to be cytotoxic. A mass spectrometry (MS)-based metabolomics approach was used to determine the chemical composition of the extracts. This analysis highlighted clear differences in the metabolomes of three sponge specimens, and all of them were identified as Haliclona (Rhizoniera) rosea (Bowerbank, 1866). Therefore, these specimens were selected for further investigation...
February 22, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28241412/removal-capacities-of-polycyclic-aromatic-hydrocarbons-pahs-by-a-newly-isolated-strain-from-oilfield-produced-water
#8
Yi-Bin Qi, Chen-Yu Wang, Cheng-Yuan Lv, Zeng-Min Lun, Cheng-Gang Zheng
The polycyclic aromatic hydrocarbon (PAH)-degrading strain Q8 was isolated from oilfield produced water. According to the analysis of a biochemical test, 16S rRNA gene, house-keeping genes and DNA-DNA hybridization, strain Q8 was assigned to a novel species of the genus Gordonia. The strain could not only grow in mineral salt medium (MM) and utilize naphthalene and pyrene as its sole carbon source, but also degraded mixed naphthalene, phenanthrene, anthracene and pyrene. The degradation ratio of these four PAHs reached 100%, 95...
February 22, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28241315/development-of-a-chromatic-pupillography-protocol-for-the-first-gene-therapy-trial-in-patients-with-cnga3-linked-achromatopsia
#9
Jolanta Lisowska, Lukasz Lisowski, Carina Kelbsch, Fumiatsu Maeda, Paul Richter, Susanne Kohl, Ditta Zobor, Torsten Strasser, Krunoslav Stingl, Eberhart Zrenner, Tobias Peters, Helmut Wilhelm, M Dominik Fischer, Barbara Wilhelm
Purpose: To establish a feasible and sensitive pupillographic protocol to assess outer and inner retinal function for the first gene therapy trial in achromatopsia patients (ACHM) with mutations in CNGA3. Methods: Twenty-seven CNGA3-ACHM patients and 22 age-matched control subjects were tested using chromatic pupillography. Three different protocols were established to assess the pupillary light reflex parameters and to create the final protocol. In the individual protocols, various stimulus parameters (i...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28241268/long-term-outcomes-after-autologous-hematopoietic-stem-cell-transplantation-for-multiple-sclerosis
#10
Paolo A Muraro, Marcelo Pasquini, Harold L Atkins, James D Bowen, Dominique Farge, Athanasios Fassas, Mark S Freedman, George E Georges, Francesca Gualandi, Nelson Hamerschlak, Eva Havrdova, Vassilios K Kimiskidis, Tomas Kozak, Giovanni L Mancardi, Luca Massacesi, Daniela A Moraes, Richard A Nash, Steven Pavletic, Jian Ouyang, Montserrat Rovira, Albert Saiz, Belinda Simoes, Marek Trnený, Lin Zhu, Manuela Badoglio, Xiaobo Zhong, Maria Pia Sormani, Riccardo Saccardi
Importance: Autologous hematopoietic stem cell transplantation (AHSCT) may be effective in aggressive forms of multiple sclerosis (MS) that fail to respond to standard therapies. Objective: To evaluate the long-term outcomes in patients who underwent AHSCT for the treatment of MS in a large multicenter cohort. Design, Setting, and Participants: Data were obtained in a multicenter, observational, retrospective cohort study. Eligibility criteria were receipt of AHSCT for the treatment of MS between January 1995 and December 2006 and the availability of a prespecified minimum data set comprising the disease subtype at baseline; the Expanded Disability Status Scale (EDSS) score at baseline; information on the administered conditioning regimen and graft manipulation; and at least 1 follow-up visit or report after transplant...
February 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28240891/approach-for-pesticide-residue-analysis-for-metabolite-prothioconazole-desthio-in-animal-origin-food
#11
Hui Liu, Guojun Yao, Xueke Liu, Chang Liu, Jing Zhan, Donghui Liu, Peng Wang, Zhiqiang Zhou
The food safety problems such as the damage to immune system, nervous and endocrine leading to cancer and malformations has received people's increasing attention. In order to achieve the MRLs, the most discussed method of HPLC-MS/MS is widely used with a advantage of high precision and resolution. Prothioconazole is a broad-spectrum thiocarbamate fungicide. It can rapidly metabolize to prothioconazole-desthio in different matrix. Rapid and effective methods for the determination of prothioconazole-desthio in five kinds of different animal food were developed...
February 27, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28240801/longitudinal-quantitative-mri-assessment-of-cortical-damage-in-multiple-sclerosis-a-pilot-study
#12
René-Maxime Gracien, Sarah C Reitz, Stephanie-Michelle Hof, Vinzenz Fleischer, Amgad Droby, Mathias Wahl, Helmuth Steinmetz, Sergiu Groppa, Ralf Deichmann, Johannes C Klein
PURPOSE: Quantitative MRI (qMRI) allows assessing cortical pathology in multiple sclerosis (MS) on a microstructural level, where cortical damage has been shown to prolong T1 -relaxation time and increase proton density (PD) compared to controls. However, the evolution of these changes in MS over time has not been investigated so far. In this pilot study we used an advanced method for the longitudinal assessment of cortical tissue change in MS patients with qMRI in comparison to cortical atrophy, as derived from conventional MRI...
February 27, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28240591/increased-immunoreactivity-against-human-cytomegalovirus-ul83-in-systemic-sclerosis
#13
Emmanouela Marou, Christos Liaskos, Georgios Efthymiou, Efthymios Dardiotis, Alexandros Daponte, Thomas Scheper, Wolfgang Meyer, Georgios Hadjigeorgiou, Dimitrios P Bogdanos, Lazaros I Sakkas
OBJECTIVES: To study immunoreactivity against human cytomegalovirus (HCMV) in systemic sclerosis (SSc), since HCMV has been put forward as a candidate infectious cause. METHODS: Eighty four patients with SSc (67 females; median age 60 years, range 25-81), 30 patients with multiple sclerosis (MS) (23 females; median age 44, range 20-69 years) and 28 healthy controls (NCs), all pre-tested positive for IgG anti-HCMV antibodies, were studied. IgG anti-UL83 HCMV antibodies were tested by western immunoblotting and expressed in arbitrary units (AUs)...
February 27, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28240418/analysis-of-drugs-of-abuse-in-cerumen-correlation-of-postmortem-analysis-results-with-those-for-blood-urine-and-hair
#14
Sylvia I Meier, Sarah C Koelzer, Manfred Schubert-Zsilavecz, Stefan W Toennes
The evaluation of drug and alcohol abuse is a major subject of forensic toxicology. Assessment of drug abstinence currently requires the analysis of urine or hair. In the present study cerumen, a mixture of sebum and sweat, was tested as an alternative. Postmortem samples (blood, urine, hair and cerumen from 38 corpses) were analyzed using liquid chromatography and gas chromatography, each coupled to mass spectrometry (LC-MS, GC-MS). The results were compared. In all cases of recent drug use (i.e. detection of opiates, amphetamine and derivatives, cocaine, methadone and diazepam or their metabolites in blood) the corresponding cerumen was positive...
February 27, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28240392/abnormal-task-driven-neural-oscillations-in-multiple-sclerosis-a-visuomotor-meg-study
#15
Eleanor L Barratt, Prejaas K Tewarie, Margareta A Clarke, Emma L Hall, Penny A Gowland, Peter G Morris, Susan T Francis, Nikos Evangelou, Matthew J Brookes
Multiple sclerosis (MS) is a debilitating disease commonly attributed to degradation of white matter myelin. Symptoms include fatigue, as well as problems associated with vision and movement. Although areas of demyelination in white matter are observed routinely in patients undergoing MRI scans, such measures are often a poor predictor of disease severity. For this reason, it is instructive to measure associated changes in brain function. Widespread white-matter demyelination may lead to delays of propagation of neuronal activity, and with its excellent temporal resolution, magnetoencephalography can be used to probe such delays in controlled conditions (e...
February 27, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28240232/venomics-of-tropidolaemus-wagleri-the-sexually-dimorphic-temple-pit-viper-unveiling-a-deeply-conserved-atypical-toxin-arsenal
#16
Choo Hock Tan, Kae Yi Tan, Michelle Khai Khun Yap, Nget Hong Tan
Tropidolaemus wagleri (temple pit viper) is a medically important snake in Southeast Asia. It displays distinct sexual dimorphism and prey specificity, however its venomics and inter-sex venom variation have not been thoroughly investigated. Applying reverse-phase HPLC, we demonstrated that the venom profiles were not significantly affected by sex and geographical locality (Peninsular Malaya, insular Penang, insular Sumatra) of the snakes. Essentially, venoms of both sexes share comparable intravenous median lethal dose (LD50) (0...
February 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28240206/-dna-sequences-from-mobile-genetic-elements-a-hidden-half-of-the-human-genome
#17
Julie Medina, Hervé Perron
Current data estimate that mobile genetic elements represent more than one-half of the human genome. The literature is constantly updating data following the evolution of sequencing techniques and of algorithms for genome analyses. This review aims to provide an overview of the topic showing the complexity given by the various designations and classifications found in scientific papers. A particular focus is made on retrotransposons, including Endogenous RetroViruses (ERV), to introduce a second article focusing on their activation and their involvement in physiological functions and/or pathological mechanisms associated with diseases like multiple sclerosis (MS) or amyotrophic lateral sclerosis (ALS)...
February 2017: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/28240190/demonstration-of-biological-and-immunological-equivalence-of-a-generic-glatiramer-acetate
#18
Josephine D D Alessandro, Kevin Garofalo, Ganlin Zhao, Christopher Honan, Jay Duffner, Ishan Capila, Ian Fier, Ganesh Kaundinya, Daniel Kantor, Tanmoy Ganguly
In April 2015, the US Food and Drug Administration approved the first generic glatiramer acetate, Glatopa® (M356), as fully substitutable for Copaxone® 20 mg/mL for relapsing forms of multiple sclerosis (MS). This approval was accomplished through an Abbreviated New Drug Application that demonstrated equivalence to Copaxone. In vitro and in vivo experiments from multiple redundant orthogonal assays within four biological processes (aggregate biology, antigen-presenting cell biology, T-cell biology, and B-cell biology) modulated by glatiramer acetate in MS established the biological and immunological equivalence of Glatopa and Copaxone and are described...
February 23, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28239976/high-speed-maldi-ms-ms-imaging-mass-spectrometry-using-continuous-raster-sampling
#19
Boone M Prentice, Chad W Chumbley, Richard M Caprioli
No abstract text is available yet for this article.
August 2016: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28239973/a-liquid-chromatography-atmospheric-pressure-photoionization-tandem-mass-spectrometric-lc-appi-ms-ms-method-for-the-determination-of-triterpenoids-in-medicinal-plant-extracts
#20
Luciana Assis Gobo, Carine Viana, Osmar Alves Lameira, Leandro Machado de Carvalho
An analytical method using liquid chromatography-atmospheric pressure photoionization tandem mass spectrometry with toluene as a dopant was developed for the determination of triterpenes in medicinal plant extracts. The 12 compounds determined have been shown to exhibit biological activity, such as gastroprotective, hepatoprotective, anti-inflammatory, antiviral and anti-tumor effects. The parameters of the atmospheric pressure photoionization interface were optimized to obtain the highest possible sensitivity for all of the compounds...
August 2016: Journal of Mass Spectrometry: JMS
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