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Modelling somatic growth

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https://www.readbyqxmd.com/read/28424200/whole-exome-sequencing-of-metaplastic-breast-carcinoma-indicates-monoclonality-with-associated-ductal-carcinoma-component
#1
Bracha Avigdor, Katie Beierl, Christopher D Gocke, Daniel Zabransky, Karen Cravero, Kelly Kyker-Snowman, Berry Button, David Chu, Sarah Croessmann, Rory L Cochran, Roisin Connolly, Ben Ho Park, Ashley Cimino-Mathews, Sarah J Wheelan
Although most human cancers display a single histology, there are unusual cases where two or more distinct tissue types present within a primary tumor. One such example is metaplastic breast carcinoma, a rare but aggressive cancer with a heterogenous histology, including squamous, chondroid, and spindle cells. Metaplastic carcinomas often contain an admixed conventional ductal invasive or in situ mammary carcinoma component, and are typically triple-negative for estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 (HER-2) amplification/overexpression...
April 19, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28414787/water-abstraction-affects-abundance-size-structure-and-growth-of-two-threatened-cyprinid-fishes
#2
Roberto Merciai, Carlota Molons-Sierra, Sergi Sabater, Emili García-Berthou
Hydrologic alteration is a major threat to freshwater biota, and particularly fish, in many river courses around the world. We analyzed and compared the effects of water abstraction on two threatened cyprinid fishes of contrasting ecology (the Mediterranean barbel Barbus meridionalis and the Catalan chub Squalius laietanus) in a Mediterranean stream. We compared abundance, size-structure, growth, and condition of both species across perennial and artificially intermittent reaches affected by water abstraction...
2017: PloS One
https://www.readbyqxmd.com/read/28410228/identification-of-a-novel-functional-jak1-s646p-mutation-in-acute-lymphoblastic-leukemia
#3
Qian Li, Botao Li, Liangding Hu, Hongmei Ning, Min Jiang, Danhong Wang, Tingting Liu, Bin Zhang, Hu Chen
The survival rate of childhood acute lymphoblastic leukemia (ALL) is approaching 90%, while the prognosis of adults remains poor due to the limited therapeutic approaches. In order to identify new targets for ALL, we performed whole-exome sequencing on four adults with B-ALL and discovered a somatic JAK1 S646P mutation. Sanger sequencing of JAK1 was conducted on 53 ALL patients, and two cases exhibited A639G and P960S mutations separately. Functional studies demonstrated that only JAK1 S646P mutation could activate multiple signaling pathways, drive cytokine-independent cell growth, and promote proliferation of malignant cells in nude mice...
March 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28406502/self-regulatory-factors-of-embryonic-stem-cells-in-co-culture-with-stromal-cells-enhance-neural-differentiation
#4
R Joshi, J C Buchanan, H Tavana
Embryonic stem cells (ESCs), due to their intrinsic capability to generate somatic cells of all three germ layers, are potential sources of neural cells for cell replacement therapies. However, the empirical differentiation protocols and the lack of mechanistic understanding of the neural differentiation of ESCs have limited the utility of ESCs as a developmental model or as a cell source for neural cell populations for replacement therapies. Co-culturing ESCs with stromal cells is one of the extensively used methods to induce neural differentiation...
April 13, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/28396902/progressive-skeletal-benefits-of-physical-activity-when-young-as-assessed-at-the-midshaft-humerus-in-male-baseball-players
#5
S J Warden, A M Weatherholt, A S Gudeman, D C Mitchell, W R Thompson, R K Fuchs
Physical activity benefits the skeleton, but there is contrasting evidence regarding whether benefits differ at different stages of growth. The current study demonstrates that physical activity should be encouraged at the earliest age possible and be continued into early adulthood to gain most skeletal benefits. INTRODUCTION: The current study explored physical activity-induced bone adaptation at different stages of somatic maturity by comparing side-to-side differences in midshaft humerus properties between male throwing athletes and controls...
April 10, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28379630/uv-induced-somatic-mutations-elicit-a-functional-t-cell-response-in-the-yummer1-7-mouse-melanoma-model
#6
Jake Wang, Curtis Jamison Perry, Katrina Meeth, Durga Thakral, William Damsky, Goran Micevic, Susan Kaech, Kim Blenman, Marcus Bosenberg
Human melanomas exhibit relatively high somatic mutation burden compared to other malignancies. These somatic mutations may produce neoantigens that are recognized by the immune system, leading to an anti-tumor response. By irradiating a parental mouse melanoma cell line carrying three driver mutations with UVB and expanding a single cell clone, we generated a mutagenized model that exhibits high somatic mutation burden. When inoculated at low cell numbers in immunocompetent C57BL/6J mice, YUMMER1.7 (YUMM Exposed to Radiation) regresses after a brief period of growth...
April 5, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28378354/ecological-regime-shift-drives-declining-growth-rates-of-sea-turtles-throughout-the-west-atlantic
#7
Karen A Bjorndal, Alan B Bolten, Milani Chaloupka, Vincent S Saba, Cláudio Bellini, Maria A G Marcovaldi, Armando J B Santos, Luis Felipe Wurdig Bortolon, Anne B Meylan, Peter A Meylan, Jennifer Gray, Robert Hardy, Beth Brost, Michael Bresette, Jonathan C Gorham, Stephen Connett, Barbara Van Sciver Crouchley, Mike Dawson, Deborah Hayes, Carlos E Diez, Robert P van Dam, Sue Willis, Mabel Nava, Kristen M Hart, Michael S Cherkiss, Andrew G Crowder, Clayton Pollock, Zandy Hillis-Starr, Fernando A Muñoz Tenería, Roberto Herrera-Pavón, Vanessa Labrada-Martagón, Armando Lorences, Ana Negrete-Philippe, Margaret M Lamont, Allen M Foley, Rhonda Bailey, Raymond R Carthy, Russell Scarpino, Erin McMichael, Jane A Provancha, Annabelle Brooks, Adriana Jardim, Milagros López-Mendilaharsu, Daniel González-Paredes, Andrés Estrades, Alejandro Fallabrino, Gustavo Martínez-Souza, Gabriela M Vélez-Rubio, Ralf H Boulon, Jaime A Collazo, Robert Wershoven, Vicente Guzmán Hernández, Thomas B Stringell, Amdeep Sanghera, Peter B Richardson, Annette C Broderick, Quinton Phillips, Marta Calosso, John A B Claydon, Tasha L Metz, Amanda L Gordon, Andre M Landry, Donna J Shaver, Janice Blumenthal, Lucy Collyer, Brendan J Godley, Andrew McGowan, Matthew J Witt, Cathi L Campbell, Cynthia J Lagueux, Thomas L Bethel, Lory Kenyon
Somatic growth is an integrated, individual-based response to environmental conditions, especially in ectotherms. Growth dynamics of large, mobile animals are particularly useful as bio-indicators of environmental change at regional scales. We assembled growth rate data from throughout the West Atlantic for green turtles, Chelonia mydas, which are long-lived, highly migratory, primarily herbivorous mega-consumers that may migrate over hundreds to thousands of kilometers. Our dataset, the largest ever compiled for sea turtles, has 9690 growth increments from 30 sites from Bermuda to Uruguay from 1973 to 2015...
April 4, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28373677/dynamics-of-single-human-embryonic-stem-cells-and-their-pairs-a-quantitative-analysis
#8
L E Wadkin, L F Elliot, I Neganova, N G Parker, V Chichagova, G Swan, A Laude, M Lako, A Shukurov
Numerous biological approaches are available to characterise the mechanisms which govern the formation of human embryonic stem cell (hESC) colonies. To understand how the kinematics of single and pairs of hESCs impact colony formation, we study their mobility characteristics using time-lapse imaging. We perform a detailed statistical analysis of their speed, survival, directionality, distance travelled and diffusivity. We confirm that single and pairs of cells migrate as a diffusive random walk for at least 7 hours of evolution...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28365405/novel-insights-into-cardiac-remodelling-revealed-by-proteomic-analysis-of-the-trout-heart-during-exercise-training
#9
Laura A Dindia, Sarah L Alderman, Todd E Gillis
The changes in the cardiac proteome of rainbow trout (Oncorhynchus mykiss) were quantified during the early phases (4, 7, and 14d) of a typical exercise-training regime to provide a comprehensive overview of the cellular changes responsible for developing a trained heart phenotype. Enhanced somatic growth during the 14d experiment was paralleled by cardiac growth to maintain relative ventricular mass. This was reflected in the cardiac proteome by the increased abundance of contractile proteins and cellular integrity proteins as early as Day 4, including a pronounced and sustained increase in blood vessel epicardial substance - an intercellular adhesion protein expressed in the vertebrate heart...
March 29, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28356144/amplification-and-up-regulation-of-mir30d-was-associated-with-disease-progression-of-cervical-squamous-cell-carcinomas
#10
You Zhou, Yinghua Hao, Yuxia Li, Ruizhen Li, Ruifang Wu, Shubin Wang, Zhengyu Fang
BACKGROUND: Cervical squamous cell carcinoma (CSCC) is the most frequent type among cervical cancers. Although the altered miRNA miR-30d expression and the amplified chromosome locus of MIR30D, 8q24, have been reported in somatic cancers, the definitive functional impact of such region especially in CSCC remains under-investigated. METHODS: One hundred thirty-six cases of CSCC tissues and matched adjacent normal ovarian epithelial tissues were assessed in this study...
March 29, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28350875/effects-of-embryo-derived-exosomes-on-the-development-of-bovine-cloned-embryos
#11
Pengxiang Qu, Suzhu Qing, Ruiqi Liu, Hongyu Qin, Weiwei Wang, Fang Qiao, Hui Ge, Jun Liu, Yong Zhang, Wei Cui, Yongsheng Wang
The developmental competence of in vitro cultured (IVC) embryos is markedly lower than that of their in vivo counterparts, suggesting the need for optimization of IVC protocols. Embryo culture medium is routinely replaced three days after initial culture in bovine, however, whether this protocol is superior to continuous nonrenewal culture method under current conditions remains unclear. Using bovine somatic cell nuclear transfer (SCNT) embryos as the model, our results showed that compared with routine renewal treatment, nonrenewal culture system significantly improved blastocyst formation, blastocyst quality (increased total cell number, decreased stress and apoptosis, enhanced Oct-4 expression and ratio of ICM/TE), as well as following development to term...
2017: PloS One
https://www.readbyqxmd.com/read/28338722/dissecting-the-transcriptional-patterns-of-social-dominance-across-teleosts
#12
Suzy C P Renn, Cynthia F O'Rourke, Nadia Aubin-Horth, Eleanor J Fraser, Hans A Hofmann
In many species, under varying ecological conditions, social interactions among individuals result in the formation of dominance hierarchies. Despite general similarities, there are robust differences among dominance hierarchies across species, populations, environments, life stages, sexes, and individuals. Understanding the proximate mechanisms underlying the variation is an important step toward understanding the evolution of social behavior. However, physiological changes associated with dominance, such as gonadal maturation and somatic growth, often complicate efforts to identify the specific underlying mechanisms...
December 16, 2016: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/28338660/germline-and-somatic-genetics-of-osteosarcoma-connecting-aetiology-biology-and-therapy
#13
REVIEW
D Matthew Gianferante, Lisa Mirabello, Sharon A Savage
Clinical outcomes and treatment modalities for osteosarcoma, the most common primary cancer of bone, have changed very little over the past 30 years. The peak incidence of osteosarcoma occurs during the adolescent growth spurt, which suggests that bone growth and pubertal hormones are important in the aetiology of the disease. Tall stature, high birth weight and certain inherited cancer predisposition syndromes are well-described risk factors for osteosarcoma. Common genetic variants are also associated with osteosarcoma...
March 24, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28337032/drosophila-dyskerin-is-required-for-somatic-stem-cell-homeostasis
#14
Rosario Vicidomini, Arianna Petrizzo, Annamaria di Giovanni, Laura Cassese, Antonella Anna Lombardi, Caterina Pragliola, Maria Furia
Drosophila represents an excellent model to dissect the roles played by the evolutionary conserved family of eukaryotic dyskerins. These multifunctional proteins are involved in the formation of H/ACA snoRNP and telomerase complexes, both involved in essential cellular tasks. Since fly telomere integrity is guaranteed by a different mechanism, we used this organism to investigate the specific role played by dyskerin in somatic stem cell maintenance. To this aim, we focussed on Drosophila midgut, a hierarchically organized and well characterized model for stemness analysis...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28333937/variability-in-age-and-size-at-maturation-reproductive-longevity-and-long-term-growth-dynamics-for-kemp-s-ridley-sea-turtles-in-the-gulf-of-mexico
#15
Larisa Avens, Lisa R Goshe, Lewis Coggins, Donna J Shaver, Ben Higgins, Andre M Landry, Rhonda Bailey
Effective management of protected sea turtle populations requires knowledge not only of mean values for demographic and life-history parameters, but also temporal and spatial trends, variability, and underlying causes. For endangered Kemp's ridley sea turtles (Lepidochelys kempii), the need for baseline information of this type has been emphasized during attempts to understand causes underlying the recent truncation in the recovery trajectory for nesting females. To provide insight into variability in age and size at sexual maturation (ASM and SSM) and long-term growth patterns likely to influence population trends, we conducted skeletochronological analysis of humerus bones from 333 Kemp's ridleys stranded throughout the Gulf of Mexico (GOM) from 1993 to 2010...
2017: PloS One
https://www.readbyqxmd.com/read/28320919/pan-cancer-analysis-distinguishes-transcriptional-changes-of-aneuploidy-from-proliferation
#16
Christopher Buccitelli, Lorena Salgueiro, Konstantina Rowald, Rocio Sotillo, Balca R Mardin, Jan O Korbel
Patterns of gene expression in tumors can arise as a consequence of or result in genomic instability, characterized by the accumulation of somatic copy number alterations (SCNAs) and point mutations (PMs). Expression signatures have been widely used as markers for genomic instability, and both SCNAs and PMs could be thought to associate with distinct signatures given their different formation mechanisms. Here we test this notion by systematically investigating SCNA, PM, and transcriptome data from 2660 cancer patients representing 11 tumor types...
April 2017: Genome Research
https://www.readbyqxmd.com/read/28317937/identification-of-cancer-associated-missense-mutations-in-hace1-that-impair-cell-growth-control-and-rac1-ubiquitylation
#17
Emilie Andrio, Romain Lotte, Daniel Hamaoui, Jacqueline Cherfils, Anne Doye, Mads Daugaard, Poul H Sorensen, Frédéric Bost, Raymond Ruimy, Amel Mettouchi, Emmanuel Lemichez
The E3 ubiquitin ligase HACE1 is a potent tumor suppressor that controls cell proliferation and ubiquitylates the small GTPase Rac1 to target it to proteasomal degradation. Whether and how the activity of HACE1 is regulated by the N-terminal ankyrin (ANK) and the middle (MID) domains is ill defined. Here, we identified in the version 64 of the Catalogue of Somatic Mutations in Cancer (COSMIC) 13 missense mutations of hace1 located outside the HECT domain, and found that all lead to defective control of cell proliferation...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28315838/germline-proliferation-is-regulated-by-somatic-endocytic-genes-via-jnk-and-bmp-signaling-in-drosophila
#18
Yaning Tang, Qing Geng, Di Chen, Shaowei Zhao, Xian Liu, Zhaohui Wang
Signals derived from the microenvironment contribute greatly to tumorigenesis. The underlying mechanism requires thorough investigation. Here, we use Drosophila testis as a model system to address this question, taking the advantage of the ease to distinguish germline and somatic cells and to track the cell numbers. In an EMS mutagenesis screen, we identified Rab5, a key factor in endocytosis, for its non-autonomous role in germline proliferation. The disruption of Rab5 in somatic cyst cells, which escort the development of germline lineage, induced the over-proliferation of under-differentiated but genetically wild-type germ cells...
March 17, 2017: Genetics
https://www.readbyqxmd.com/read/28285640/first-and-second-trimester-gestational-weight-gains-are-most-strongly-associated-with-cord-blood-levels-of-hormones-at-delivery-important-for-glycemic-control-and-somatic-growth
#19
Sheryl L Rifas-Shiman, Abby Fleisch, Marie-France Hivert, Christos Mantzoros, Matthew W Gillman, Emily Oken
BACKGROUND: Excessive gestational weight gain (GWG) during pregnancy is associated with adverse outcomes for mothers and offspring. Early, mid, and late pregnancy GWGs have different associations with fetal growth and later life adiposity, but associations with cord blood hormones, which might predict later health, are not well studied. METHODS: In 978 pregnant women from the pre-birth Project Viva cohort, we calculated trimester-specific GWG using clinically recorded prenatal weights...
April 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28273182/protocol-for-efficient-regulation-of-in-vitro-morphogenesis-in-einkorn-triticum-monococcum-l-a-recalcitrant-diploid-wheat-species
#20
Dmitry Miroshnichenko, Inna Chaban, Mariya Chernobrovkina, Sergey Dolgov
Einkorn (Triticum monococcum L.) is A-genome diploid wheat that has a potential to become a useful model for understanding the biology and genomics in Triticeae. Unfortunately, the application of modern technologies such as genetic engineering, RNAi-based gene silencing and genome editing is not available for einkorn as there is no efficient in vitro tissue culture and plant regeneration system. In the present study an efficient and simple protocol for plant regeneration via direct or indirect somatic embryogenesis and organogenesis has been developed...
2017: PloS One
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