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https://www.readbyqxmd.com/read/27933314/tunneling-nanotubes-an-alternate-route-for-propagation-of-the-bystander-effect-following-oncolytic-viral-infection
#1
Justin Ady, Venugopal Thayanithy, Kelly Mojica, Phillip Wong, Joshua Carson, Prassanna Rao, Yuman Fong, Emil Lou
Tunneling nanotubes (TNTs) are ultrafine, filamentous actin-based cytoplasmic extensions which form spontaneously to connect cells at short and long-range distances. We have previously described long-range intercellular communication via TNTs connecting mesothelioma cells in vitro and demonstrated TNTs in intact tumors from patients with mesothelioma. Here, we investigate the ability of TNTs to mediate a viral thymidine kinase based bystander effect after oncolytic viral infection and administration of the nucleoside analog ganciclovir...
2016: Molecular Therapy Oncolytics
https://www.readbyqxmd.com/read/27931021/a-retrospective-analysis-of-neonatal-encephalocele-predisposing-factors-and-outcomes
#2
Seyho Cem Yucetas, Necati Uçler
OBJECTIVE: This study evaluates the predisposing factors and outcomes of surgical management of encephaloceles at our institution. MATERIALS AND METHODS: A retrospective analysis of 32 occipital encephaloceles managed operatively at the Neurosurgery Department Clinics of the Faculty of Medicine, Adıyaman University, was performed between 2011 and 2015. RESULTS: Among the study population, 19 mothers had been exposed to TORCH infections (toxoplasma, rubella, cytomegalovirus, herpes simplex virus), 18 were in consanguineous marriages, and 3 had regular prenatal screening...
December 9, 2016: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27930721/both-cerebral-and-hematopoietic-deficiencies-in-ccr2-result-in-uncontrolled-herpes-simplex-virus-infection-of-the-central-nervous-system-in-mice
#3
Rafik Menasria, Coraline Canivet, Jocelyne Piret, Jean Gosselin, Guy Boivin
CCR2 is a chemokine receptor expressed on the surface of blood leukocytes, particularly «Ly6Chi» inflammatory monocytes and microglia. Signaling through this receptor is thought to influence the immune activity of microglia as well as monocytes egress from the bone marrow (BM) and their trafficking into the central nervous system (CNS) in several neurological diseases. During experimental herpes simplex virus 1 (HSV-1) encephalitis (HSE), CCR2 deficiency has been reported to exacerbate the outcome of the disease...
2016: PloS One
https://www.readbyqxmd.com/read/27929612/effects-of-cumulative-herpesviridae-and-toxoplasma-gondii-infections-on-cognitive-function-in-healthy-bipolar-and-schizophrenia-subjects
#4
Nora Hamdani, Claire Daban-Huard, Ophelia Godin, Hakim Laouamri, Stéphane Jamain, Dodji Attiba, Marine Delavest, Jean-Pierre Lépine, Philippe Le Corvoisier, Josselin Houenou, Jean-Romain Richard, Robert H Yolken, Rajagopal Krishnamoorthy, Ryad Tamouza, Marion Leboyer, Faith B Dickerson
OBJECTIVE: Schizophrenia and bipolar disorder are associated with cognitive impairment leading to social disruption. While previous studies have focused on the effect of individual infectious exposure, namely, Herpesviridae viruses or Toxoplasma gondii (T gondii), on cognitive functioning, the objective of the present study was to examine the effect of multiple infections on cognitive functioning in patients with schizophrenia and bipolar disorder and in healthy controls. METHODS: Seropositivity to herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), cytomegalovirus (CMV), and T gondii was related to cognitive status among 423 participants (recruited between 2008 and 2014; 138 patients with bipolar disorder, 105 patients with schizophrenia [DSM-IV criteria], and 180 healthy controls) for episodic verbal memory (California Verbal Learning Test), working memory (Wechsler Adult Intelligence Scale, third edition), and premorbid intelligence quotient (National Adult Reading Test)...
December 6, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27929270/sexually-transmitted-infections-recommendations-from-the-u-s-preventive-services-task-force
#5
Karen C Lee, Quyen Ngo-Metzger, Tracy Wolff, Joya Chowdhury, Michael L LeFevre, David S Meyers
The U.S. Preventive Services Task Force (USPSTF) has issued recommendations on behavioral counseling to prevent sexually transmitted infections (STIs) and recommendations about screening for individual STIs. Clinicians should obtain a sexual history to assess for behaviors that increase a patient's risk. Community and population risk factors should also be considered. The USPSTF recommends intensive behavioral counseling for all sexually active adolescents and for adults whose history indicates an increased risk of STIs...
December 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27928013/herpes-simplex-virus-1-ul41-protein-suppresses-the-ire1-xbp1-signal-pathway-of-the-unfolded-protein-response-via-its-rnase-activity
#6
Pengchao Zhang, Chenhe Su, Zhangtao Jiang, Chunfu Zheng
: During viral infection, accumulation of viral proteins can cause stress in the endoplasmic reticulum (ER) and trigger the unfolded protein response (UPR) to restore the ER homeostasis. Inositol-requiring enzyme 1 (IRE1)-dependent pathway is the most conserved one of the three UPR signal pathways. Upon activation, IRE1 splices out an intron from the unspliced inactive form X-box binding protein 1 (XBP1(u)) mRNA and produces a transcriptionally potent spliced form (XBP1(s)). Previous studies have reported that the IRE1/XBP1 pathway is inhibited upon herpes simplex virus 1 (HSV-1) infection, however, the underlying molecular mechanism is still illusive...
December 7, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27927863/longitudinal-viral-dynamics-in-semen-during-early-hiv-infection
#7
Sheldon R Morris, Mitchell Zhao, Davey R Smith, Milenka V Vargas, Susan J Little, Sara Gianella
BACKGROUND: Multiple viruses co-infect the male genital tract, influencing each other's replication and perhaps affecting HIV pathogenesis and disease progression. METHODS: This study included 453 longitudinal seminal samples from 195 HIV-infected men from the San Diego Primary Infection Cohort and 67 seminal samples from HIV-negative healthy controls. Seminal HIV RNA and DNA from seven human herpesviruses (HHV) were measured by RT-PCR. Longitudinal shedding rates were determined by Kaplan-Meier survival analysis...
December 7, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27927119/recognition-and-management-of-sepsis-in-early-infancy
#8
Joanna Barnden, Vanessa Diamond, Paul Anthony Heaton, Siba Prosad Paul
Serious bacterial and viral infections occurring in early infancy are important factors affecting morbidity and mortality. Recognition of sepsis by healthcare professionals is vital and allows initiation of appropriate early treatment which can be life-saving and improve outcomes for these infants greatly. This article outlines the leading causes of sepsis, for example, group B Streptococcus (GBS), Escherichia coli and herpes simplex virus. We discuss the non-specific ways in which an infant with a serious infection may present to health professionals and highlight crucial features to look for in the history and during examination of an unwell infant, and these include 'red-flag' signs and symptoms that should be carefully elicited...
December 8, 2016: Nursing Children and Young People
https://www.readbyqxmd.com/read/27922859/fdg-pet-ct-for-monitoring-response-of-melanoma-to-the-novel-oncolytic-viral-therapy-talimogene-laherparepvec
#9
Matthew F Covington, Clara N Curiel, Lois Lattimore, Ryan J Avery, Phillip H Kuo
61-year-old woman with stage IIIa (T3a N1a M0) left lower leg melanoma with lesions suggestive of in-transit metastases 8 months following wide local excision and femoral nodal dissection. FDG-PET/CT demonstrated 5 FDG-avid in-transit nodal metastases in the distal left leg, confirmed on biopsy. Talimogene laherparepvec (T-VEC) oncolytic immunotherapy consisting of intralesional injections of modified herpes simplex virus-expressing granulocyte-macrophage colony-stimulating factor was completed over 6 months...
December 3, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27922851/future-prospects-for-new-vaccines-against-sexually-transmitted-infections
#10
Sami L Gottlieb, Christine Johnston
PURPOSE OF REVIEW: This review provides an update on the need, development status, and important next steps for advancing development of vaccines against sexually transmitted infections (STIs), including herpes simplex virus (HSV), Neisseria gonorrhoeae (gonorrhea), Chlamydia trachomatis (chlamydia), and Treponema pallidum (syphilis). RECENT FINDINGS: Global estimates suggest that more than a million STIs are acquired every day, and many new and emerging challenges to STI control highlight the critical need for development of new STI vaccines...
December 2, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27921084/the-prevalence-of-herpes-simplex-virus-type-1-and-2-infection-in-iran-a-meta-analysis
#11
REVIEW
Mina Malary, Ghasem Abedi, Zeinab Hamzehgardeshi, Mahdi Afshari, Mahmood Moosazadeh
BACKGROUND: Seroepidemiologic studies indicate a high prevalence of herpes simplex virus (HSV) infection. This infection leads to ophthalmic, dermatologic, oral, neurologic, vaginal and cervical problems. Different studies have been carried out to estimate the HSV seroprevalence in Iran. Combining the results of these studies would be useful for health policy-making. OBJECTIVE: This study aims to estimate the pooled prevalence of HSV infection using meta-analysis...
October 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27921058/celiac-crisis-associated-with-herpes-simplex-virus-esophagitis
#12
Alan Chen, Christopher M Linz, Julie L Tsay, Ming Jin, Samer S El-Dika
Celiac crisis is a rare presentation of celiac disease that is characterized by life-threatening electrolyte abnormalities, vitamin and mineral deficiencies, and diarrhea. Triggers for celiac crisis include major surgeries, pancreatitis, and infections of cytomegalovirus, and salmonella. A 24-year-old woman presented with celiac crisis associated with severe herpes simplex virus (HSV) esophagitis. This case demonstrates that nutritional deficiencies seen in celiac disease can result in a relative immunodeficiency, which may lead to other infectious complications...
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/27919480/extratemporal-herpes-encephalitis-during-natalizumab-treatment-a-case-report
#13
Shalom Haggiag, Luca Prosperini, Simonetta Galgani, Carlo Pozzilli, Carmela Pinnetti
Herpes simplex virus encephalitis (HSE) is a rare but often fatal disease if left untreated. MRI typically shows the characteristic findings of medial temporal lobe and insular involvement, while diagnosis in confirmed by CSF PCR. In immunocompromised state, HSE may have atypical clinical and radiological features. We report a MS patient under natalizumab treatment with HSE, who presented with MRI lesions exclusively in the right parietal lobe. The patient was timely started on acyclovir resulting in marked improvement...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919092/correction-tenofovir-and-emtricitabine-tenofovir-preexposure-prophylaxis-for-herpes-simplex-virus-type-2
#14
(no author information available yet)
No abstract text is available yet for this article.
December 6, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27918431/evaluation-of-microrna-expression-in-patients-with-herpes-zoster
#15
Xihan Li, Ying Huang, Yucheng Zhang, Na He
Reactivated varicella-zoster virus (VZV), which lies latent in the dorsal root ganglions and cranial nerves before its reactivation, is capable of causing herpes zoster (HZ), but the specific mechanism of virus reactivation and latency remains unknown. It was proposed that circulating microRNAs (miRNAs) in body fluids could potentially indicate infection. However, the connection between herpes zoster and circulating miRNAs has not been demonstrated. In this study, 41 HZ patients without superinfection were selected...
December 2, 2016: Viruses
https://www.readbyqxmd.com/read/27913959/reaction-of-complement-factors-and-proteasomes-in-experimental-encephalitis
#16
Stefan Lange, Tomas Bergström, Ewa Johansson, Merna Oshalim, Ivar Lönnroth
Herpes simplex virus type 1 (HSV-1) encephalitis causes a deleterious inflammation and elevated intracranial pressure. As a step towards examining the origin of the inflammation, we here report the response of circulating proteasomes and complement factors in blood and cerebrospinal fluid (CSF) in rats infected with HSV-1. Infection was via the nasal route, with 1.1 × 10(4) plaque-forming units of HSV-1 strain 2762 given in one or both nostrils. A sandwich enzyme-linked immunosorbent assay was used to study the level of 26S proteasomes and their complex formation with complement factors 3 and 4...
December 2, 2016: Journal of Neurovirology
https://www.readbyqxmd.com/read/27911113/a-tribute-to-professor-steven-l-wechsler-1948-2016-the-man-and-the-scientist
#17
Anthony B Nesburn, Lbachir BenMohamed
Professor Steven L. Wechsler, a world-renowned eye researcher and virologist, passed away unexpectedly on June 12, 2016 at the age of 68. Many scientists came to know Professor Wechsler as a gifted researcher in the field of ocular Herpes Simplex Virus (HSV-1) latency, reactivation, and pathogenesis. Professor Wechsler published over 150 peer-reviewed scientific papers during his career, pushing forward the frontiers of his field eye research. His colleagues would say, 'Steve literally wrote the book on herpes latency and reactivation...
December 2, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27911112/treatment-of-alpha-and-beta-herpesvirus-infections-in-solid-organ-transplant-recipients
#18
C L Abad, R R Razonable
Human herpesviruses frequently cause infections in solid organ transplant (SOT) recipients. Areas covered: We provide an overview of the clinical impact of alpha and beta herpesviruses and highlight the mechanisms of action, pharmacokinetics, clinical indications, and adverse effects of antiviral drugs for the management of herpes simplex virus, varicella zoster virus and cytomegalovirus. We comprehensively evaluated key clinical trials that led to drug approval, and served as the foundation for management guidelines...
December 2, 2016: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/27905140/herpes-simplex-infection-simulating-richter-transformation-a-series-of-four-cases-and-review-of-the-literature
#19
Alireza Salem, Sanam Loghavi, Joseph D Khoury, Rose Lou Marie C Agbay, Jeffrey L Jorgensen, Jeffrey L Medeiros
AIMS: Richter transformation (RT) occurs in 5-10% of patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and is associated with a poor outcome. Histologic manifestations of RT are variable and include an increase in the proportion of large cells including prolymphocytes, immunoblasts and other pleomorphic cells along with an increased proliferation rate and often necrosis. Rarely, superimposed Herpes simplex virus (HSV) infection involving lymph nodes in patients with CLL/SLL may mimic RT clinically and histologically...
December 1, 2016: Histopathology
https://www.readbyqxmd.com/read/27904085/antiviral-activity-and-molecular-geometry-of-some-new-symmetrical-tris-aminoalkyl-amine-derivatives
#20
Nobuko Mibu, Kazumi Yokomizo, Kana Murakami, Yurika Ono, Masato Ishimaru, Marie Otsubo, Hiroshi Inao, Yutaro Ono, Jian-Rong Zhou, Kunihiro Sumoto
We report the preparation of new tripodal receptor-type C3- and CS-symmetrical molecules constructed on a tris(2-aminoethyl)amine (TAEA) template. Both the anti-herpes simplex virus type 1 (anti-HSV-1) activity and cytotoxic activity of synthesized receptor-type derivatives were evaluated in order to find a characteristic structural feature for these bioactivities of compounds. Among the compounds of synthesized symmetrical TAEA-related derivatives, compound 13k showed high anti-HSV-1 activity (50% effective concentration (EC50)=16...
2016: Chemical & Pharmaceutical Bulletin
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