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https://www.readbyqxmd.com/read/28428867/adaptative-evolution-of-the-vkorc1-gene-in-mus-musculus-domesticus-is-influenced-by-the-selective-pressure-of-anticoagulant-rodenticides
#1
Joffrey Goulois, Véronique Lambert, Lionel Legros, Etienne Benoit, Virginie Lattard
Anticoagulant rodenticides are commonly used to control rodent pests worldwide. They specifically inhibit the vitamin K epoxide reductase (VKORC1), which is an enzyme encoded by the Vkorc1 gene, involved in the recycling of vitamin K. Therefore, they prevent blood clotting. Numerous mutations of Vkorc1 gene were reported in rodents, and some are involved in the resistant to rodenticides phenotype. Two hundred and sixty-six mice tails were received from 65 different locations in France. Coding sequences of Vkorc1 gene were sequenced in order to detect mutations...
April 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28216253/-atrial-fibrillation-and-anticoagulation-in-hemodialysis-patients-a-complex-decision
#2
Pierre Delanaye, Antoine Bouquegneau, Bernard E Dubois, Muriel Sprynger, Christophe Mariat, Jean-Marie Krzesinski, Patrizio Lancellotti
Cardiovascular mortality of hemodialysis patients remains a major problem. The prevalence and incidence of atrial fibrillation in this population are more important than in the general population. The indication of antivitamin K therapy (AVK) in this context of atrial fibrillation must be weighted against the increased risk of bleeding. Unfortunately, and contrary to the general population, an indication of anticoagulation based on embolic or hemorrhagic risk scores is not as clearly established in the hemodialysis population...
February 16, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/27939514/new-oral-anticoagulants-in-patients-with-chronic-kidney-disease
#3
Lara Belmar Vega, A L M de Francisco, Jairo Bada da Silva, Luis Galván Espinoza, Gema Fernández Fresnedo
Patients with chronic kidney disease (CKD) develop bleeding and thrombotic tendencies, so the indication of anticoagulation at the onset of atrial fibrillation (AF) is complex. AF is the most common chronic cardiac arrhythmia, and thromboembolism and ischemic stroke in particular are major complications. In recent years, new oral anticoagulant drugs have been developed, and they have shown superiority over the classical AVK in preventing stroke, systemic embolism and bleeding risk, constituting an effective alternative to those resources...
December 8, 2016: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/27932859/central-corneal-thickness-of-iraqi-population-in-relation-to-age-gender-refractive-errors-and-corneal-curvature-a-hospital-based-cross-sectional-study
#4
Yasir Jawad Kadhim, Qasim K Farhood
BACKGROUND: Central corneal thickness (CCT) is an important indicator of corneal status. Its measurement provides valid information about corneal physiological condition and possible changes associated with diseases, traumas, and hypoxia. It is an integral part for interpretation of intraocular pressure and glaucoma patient management and in prerefractive procedure assessment. OBJECTIVE: The aim of this study is to determine the mean CCT among a normal Iraqi population and to correlate between CCT and age, gender, refraction, and corneal curvature...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27925230/role-of-abc-transporters-in-trans-epithelial-transport-of-vitamin-k-antagonists
#5
Bernadette Espana, Solange Couturier, Caroline Prouillac
Vitamin K antagonists (VKAs) remain the oral anticoagulant of choice in venous thromboembolic disease. These drugs are characterized by a large inter-individual variability requiring frequent dose tailoring. Genetic polymorphisms for cytochrome CYP2C9 and VKORC1 explain some of the variability, especially in warfarin and acenocoumarol responses. The aim of this study was to assess, in cell models, the role of ABC transporters in the intestinal transfer of the main coumarin derivatives (warfarin, acenocoumarol) and indanedione derivatives (phenindione, fluindione)...
January 2017: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/27861826/medication-overuse-headache-protocols-and-outcomes-in-149-consecutive-patients-in-a-tertiary-brazilian-headache-center
#6
Abouch V Krymchantowski, Stewart J Tepper, Carla Jevoux, Marcelo Valença
AIM: Medication-overuse headache (MOH) is a challenging clinical disorder often resulting in frustration for patients and physicians. Adherence issues are common and limited treatment evidence is an obstacle to effective care. Individual bias usually directs the treatment. The aim of this study was to evaluate outcome and treatment strategies in consecutive MOH patients from a tertiary center. METHODS: Every consecutive patient seen between January and December 2014 with the diagnosis of MOH was included...
January 2017: Headache
https://www.readbyqxmd.com/read/27836741/guidelines-of-the-french-society-of-otorhinolaryngology-sforl-managing-epistaxis-under-coagulation-disorder-due-to-antithrombotic-therapy
#7
V Escabasse, E Bequignon, B Vérillaud, L Robard, J Michel, O Malard, L Crampette
OBJECTIVE: The authors present the guidelines of the French Society of Otorhinolaryngology concerning the management of epistaxis during antithrombotic therapy. METHODS: A review of the literature was performed by a multidisciplinary work group. Guidelines were drafted, then re-edited by a reading group independent of the work group to produce the final text. The proposed recommendations were graded A, B, C or expert opinion, on decreasing levels of evidence. RESULTS: Before any decision to modify antithrombotic treatment, it is recommended to screen for overdose and assess the risk of thrombosis...
November 8, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/27754958/point-of-care-testing-inr-an-overview
#8
Doris Barcellona, Lara Fenu, Francesco Marongiu
Oral anticoagulant therapies with the anti-vitamin K drugs (AVK), warfarin, acenocoumarol and phenprocoumon, are employed in primary and secondary anti-thrombotic prophylaxis in patients with venous thromboembolism, atrial fibrillation and cardiac mechanical valves. However, a monitoring test such as the International Normalized Ratio (INR) is required. The periodic monitoring of this therapy entails discomfort for the patients. Telemedicine and telecare can provide significant aid in the management of this therapy allowing patients to perform the test at home or anywhere else with a portable device, i...
October 18, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27533256/stroke-prevention-in-atrial-fibrillation-focus-on-latin-america
#9
Ayrton R Massaro, Gregory Y H Lip
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, with an estimated prevalence of 1-2% in North America and Europe. The increased prevalence of AF in Latin America is associated with an ageing general population, along with poor control of key risk factors, including hypertension. As a result, stroke prevalence and associated mortality have increased dramatically in the region. Therefore, the need for effective anticoagulation strategies in Latin America is clear. The aim of this review is to provide a contemporary overview of anticoagulants for stroke prevention...
August 11, 2016: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/27222228/regulation-of-two-motor-patterns-enables-the-gradual-adjustment-of-locomotion-strategy-in-caenorhabditis-elegans
#10
Ingrid Hums, Julia Riedl, Fanny Mende, Saul Kato, Harris S Kaplan, Richard Latham, Michael Sonntag, Lisa Traunmüller, Manuel Zimmer
In animal locomotion a tradeoff exists between stereotypy and flexibility: fast long-distance travelling (LDT) requires coherent regular motions, while local sampling and area-restricted search (ARS) rely on flexible movements. We report here on a posture control system in C. elegans that coordinates these needs. Using quantitative posture analysis we explain worm locomotion as a composite of two modes: regular undulations versus flexible turning. Graded reciprocal regulation of both modes allows animals to flexibly adapt their locomotion strategy under sensory stimulation along a spectrum ranging from LDT to ARS...
May 25, 2016: ELife
https://www.readbyqxmd.com/read/27196872/study-of-the-efficiency-of-anticoagulant-rodenticides-to-control-mus-musculus-domesticus-introgressed-with-mus-spretus-vkorc1
#11
Joffrey Goulois, Claire Hascoët, Khedidja Dorani, Stéphane Besse, Lionel Legros, Etienne Benoit, Virginie Lattard
BACKGROUND: Antivitamin K anticoagulant (AVK) rodenticides are commonly used to control rodent pests worldwide. They specifically inhibit the VKORC1 enzyme essential for the recycling of vitamin K, and thus prevent blood clotting and cause death by haemorrhage. Numerous mutations or polymorphisms of the Vkorc1gene were reported in rodents and some lead to resistance to rodenticides. In house mice (Mus musculus domesticus), adaptative introgression of the Vkorc1 gene from the Algerian mouse (Mus spretus) was reported...
May 16, 2016: Pest Management Science
https://www.readbyqxmd.com/read/27080842/the-contribution-of-pharmacogenetics-to-pharmacovigilance
#12
Emmanuelle Bondon-Guitton, Fabien Despas, Laurent Becquemont
Since the beginning of this century, information on pharmacogenetics appears in the summary of product characteristics (SPC) of drugs. Pharmacogenetic tests particularly concern the enzymes involved in the metabolism of drugs, among which P450 cytochromes. Some patients known as poor metabolisers eliminate some drugs more slowly, causing overdoses and adverse drug reactions (ADRs). The best-known examples are AVK and VKORC1-CYP2C9 or clopidogrel and CYP2C19. In the USA, the tests are recommended before the introduction of these drugs to prevent the occurrence of ADRs...
April 2016: Thérapie
https://www.readbyqxmd.com/read/26924797/evaluation-of-structural-contributors-in-myopic-eyes-of-preterm-and-full-term-children
#13
COMPARATIVE STUDY
Saira Bhatti, Evelyn A Paysse, Mitch P Weikert, Lingkun Kong
PURPOSE: We conducted a cross-sectional study to test the hypothesis that the structural contributions to myopia in preterm and full-term born children are different. METHODS: In this study, 93 children ranging from ages 2 to 13 who had myopia ≥ -3 diopters in at least one eye were examined with A-scans. The following data was collected and analyzed: history of birth, refractive error (RE), cornea thickness (CT) and average corneal curvature (AVK), depth of anterior chamber (ACD), lens thickness (LT), and axial length (AL) of the eye...
May 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/26631311/-t2hd-study-oral-anticoagulants-and-antiplatelet-agents-practices-benefits-and-risks-in-the-chronic-hemodialysis-population-observational-data
#14
Alexandre Martin, Nathalie Thilly, Carole Ayav, Isabelle Clerc-Urmes, Pauline Held, Luc Frimat, Nicolas Olivier Peters
INTRODUCTION: Chronic hemodialysis patients have disorders of hemostasis associated with End Stage Renal Disease, cardiovascular disease, and treatments they receive. They have more thrombotic and bleeding events than the general population. The balance of risks and benefits of drugs is not precisely defined. The aim of this study is to describe the practices patterns concerning oral anticoagulants (AVK) and antiplatelet agents (APA), and to investigate their impact on the survival and the occurrence of thrombotic and bleeding events...
June 2016: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/26237425/long-term-events-following-atrial-fibrillation-rate-control-or-transcatheter-ablation-a-multicenter-observational-study
#15
MULTICENTER STUDY
Cristina Gallo, Alberto Battaglia, Matteo Anselmino, Francesca Bianchi, Stefano Grossi, Giulia Nangeroni, Elisabetta Toso, Luca Gaido, Marco Scaglione, Federico Ferraris, Fiorenzo Gaita
BACKGROUND: Atrial fibrillation increases thromboembolic risk. Oral anticoagulation with antivitamin K (AVK) reduces thromboembolic event rate, but increases hemorrhagic risk. OBJECTIVE: The aim of the present study was to describe long-term cerebral thromboembolic/hemorrhagic event rates in atrial fibrillation patients managed by rhythm control, pursued by atrial fibrillation transcatheter ablation (AFTCA), and rate control strategy. METHODS AND RESULTS: One thousand and five hundred consecutive patients referring to three medical care centers for atrial fibrillation were retrospectively divided into three groups: AFTCA maintaining AVK (group A); AFTCA discontinuing AVK (group B); and rate control strategy and AVK (group C)...
March 2016: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/26169011/direct-oral-anticoagulants-in-atrial-fibrillation-can-data-from-randomized-clinical-trials-be-safely-transferred-to-the-general-population-no
#16
Marco Marietta
Direct oral anticoagulants (DOAC) represent an innovative and relevant treatment for the prevention of cardiac embolism in patients with atrial fibrillation (AF). Their introduction has been followed by an ample debate on their appropriate use, considering that they can offer an effective treatment for the many patients with AF, which are not taking any effective anticoagulant treatment, even though they have a substantial thromboembolic risk (1). On the other hand, DOAC are much less tested in everyday clinical practice and much more expensive than anti-vitamin k anticoagulants (AVKs)...
September 2015: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/26148369/-emergency-treatment-of-bleeding-in-patients-taking-warfarin
#17
N V Prasolov, E M Shulutko, A Yu Bulanov, K V Yatskov, O V Shcherbakov
Anticoagulant therapy with vitamin K antagonists (AVK) is an effective treatment and prevention of thrombosis. One of the major disadvantages of the AVK is a risk for serious bleeding. Prothrombin complex concentrates (PCC), fresh frozen plasma (FFP) and vitamin K1 are available for control of these situations. The experience of special team ofthe Scientific Center for Hematology was the basis for presented retrospective study. Three regimens of warfarin-related bleeding were compared: PCC+ VK for several bleeding, FFP+ VK for different clinical situations and VKfor light bleeding...
March 2015: Anesteziologiia i Reanimatologiia
https://www.readbyqxmd.com/read/26112500/-compliance-and-patient-education-an-example-of-antivitamin-k-in-pediatric-cardiology
#18
F Bajolle, M Traore, A Grazioli, R Cheurfi, V Salle
No abstract text is available yet for this article.
May 2015: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/25956749/-anticoagulation-in-the-aged-patient-with-atrial-fibrillation-what-are-prescribing-cardiologists-geriatricians-and-general-practitioners
#19
P Fuchs, T Vogel, P-O Lang
OBJECTIVE: To assess prescribing of anticoagulants in atrial fibrillation (AF) in the elderly, both a quantitative point of view (rate of anticoagulation) and qualitative (type of anticoagulation). Determinants of prescribing and non-prescribing were also analysed. METHODS: Prospective survey of practice, based on one clinical case and questionnaire conducted in 60 practitioners (20 cardiologists [C], 20 geriatricians [G] and 20 general practitioners [GP]). RESULTS: In reading the clinical case, 88...
August 2015: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/25847836/evidence-of-a-target-resistance-to-antivitamin-k-rodenticides-in-the-roof-rat-rattus-rattus-identification-and-characterisation-of-a-novel-y25f-mutation-in-the-vkorc1-gene
#20
Joffrey Goulois, Audrey Chapuzet, Véronique Lambert, Nolan Chatron, Luba Tchertanov, Lionel Legros, Etienne Benoît, Virginie Lattard
BACKGROUND: In spite of intensive use of bromadiolone, rodent control was inefficient on a farm infested by rats in Zaragoza, Spain. While metabolic resistance was previously described in this rodent species, the observation of a target resistance to antivitamin K rodenticides had been poorly documented in Rattus rattus. RESULTS: From rats trapped on the farm, cytochrome b and Vkorc1 genes were amplified by PCR and sequenced in order to identify species and detect potential Vkorc1 mutations...
March 2016: Pest Management Science
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