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Cardiac MRI

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https://www.readbyqxmd.com/read/29912990/peptide-conjugated-phosphodiamidate-oligomer-mediated-exon-skipping-has-benefits-for-cardiac-function-in-mdx-and-cmah-mdx-mouse-models-of-duchenne-muscular-dystrophy
#1
Alison M Blain, Elizabeth Greally, Graham McClorey, Raquel Manzano, Corinne A Betts, Caroline Godfrey, Liz O'Donovan, Thibault Coursindel, Mike J Gait, Matthew J Wood, Guy A MacGowan, Volker W Straub
Cardiac failure is a major cause of mortality in patients with Duchenne muscular dystrophy (DMD). Antisense-mediated exon skipping has the ability to correct out-of-frame mutations in DMD to produce truncated but functional dystrophin. Traditional antisense approaches have however been limited by their poor uptake into cardiac muscle. The addition of cell-penetrating peptides to antisense molecules has increased their potency and improved their uptake into all muscles, including the heart. We have investigated the efficacy of the Peptide-conjugated phosphodiamidate morpholino oligomer (P-PMO) Pip6a-PMO, for restoration of cardiac dystrophin and functional rescue in DMD mice- the mdx mouse and the less well characterised Cmah-/-mdx mouse (which carry a human-like mutation in the mouse Cmah gene as well as a mutation in DMD)...
2018: PloS One
https://www.readbyqxmd.com/read/29910056/rationale-and-design-of-the-seneca-stem-cell-injection-in-cancer-survivors-trial
#2
Roberto Bolli, Joshua M Hare, Timothy D Henry, Carrie G Lenneman, Keith L March, Kathy Miller, Carl J Pepine, Emerson C Perin, Jay H Traverse, James T Willerson, Phillip C Yang, Adrian P Gee, João A Lima, Lem Moyé, Rachel W Vojvodic, Shelly L Sayre, Judy Bettencourt, Michelle Cohen, Ray F Ebert, Robert D Simari
OBJECTIVES: SENECA (StEm cell iNjECtion in cAncer survivors) is a phase I, randomized, double-blind, placebo-controlled study to evaluate the safety and feasibility of delivering allogeneic mesenchymal stromal cells (allo-MSCs) transendocardially in subjects with anthracycline-induced cardiomyopathy (AIC). BACKGROUND: AIC is an incurable and often fatal syndrome, with a prognosis worse than that of ischemic or nonischemic cardiomyopathy. Recently, cell therapy with MSCs has emerged as a promising new approach to repair damaged myocardium...
July 2018: American Heart Journal
https://www.readbyqxmd.com/read/29909774/cardiovascular-magnetic-resonance-assessment-of-acute-cardiovascular-effects-of-voluntary-apnoea-in-elite-divers
#3
L Eichhorn, J Doerner, J A Luetkens, J M Lunkenheimer, R C Dolscheid-Pommerich, F Erdfelder, R Fimmers, J Nadal, B Stoffel-Wagner, H H Schild, A Hoeft, B Zur, C P Naehle
BACKGROUND: Prolonged breath holding results in hypoxemia and hypercapnia. Compensatory mechanisms help maintain adequate oxygen supply to hypoxia sensitive organs, but burden the cardiovascular system. The aim was to investigate human compensatory mechanisms and their effects on the cardiovascular system with regard to cardiac function and morphology, blood flow redistribution, serum biomarkers of the adrenergic system and myocardial injury markers following prolonged apnoea. METHODS: Seventeen elite apnoea divers performed maximal breath-hold during cardiovascular magnetic resonance imaging (CMR)...
June 18, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29909390/atypical-chest-pain-in-a-patient-with-hydatid-cyst-of-the-interventricular-septum
#4
Santosh Modani, Davala Krishna Karthik, Shruti Heda, Anirudda Deshpande
We report a 57-year-old man presenting with symptoms of sharp pricking, exertional retrosternal chest pain multiple times, each episode lasting for a few seconds. On evaluation, the ECG of the patient showed normal sinus rhythm with T wave inversions in leads V1-V3. Troponin T test was negative. Transthoracic echocardiography showed a globular mass in the interventricular septum. Cardiac MRI was suspicious of the lesion to be a hydatid cyst. Surgical excision of the lesion followed by histopathology was confirmatory of hydatid cyst...
June 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29907089/temporarily-increased-stroke-rate-after-takotsubo-syndrome-need-for-an-anticoagulation
#5
Nadine Abanador-Kamper, Lars Kamper, Judith Wolfertz, Marc Vorpahl, Patrick Haage, Melchior Seyfarth
BACKGROUND: Previous studies have reported slightly higher stroke rates in Takotsubo Syndrome compared to acute myocardial infarction. Our goal was to evaluate the temporal course of stroke rates and left ventricular recovery in patients with Takotsubo Syndrome. METHODS: We retrospectively examined the clinical and imaging data of 72 patients with Takotsubo Syndrome. The data collected came from January 2005 to March 2017. Left ventricular performance was evaluated by cardiovascular magnetic resonance imaging (MRI) in all patients during the acute phase of Takotsubo Syndrome and in a follow-up scan 2 months later...
June 15, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29904830/migraine-and-cerebrovascular-disease-still-a-dangerous-connection
#6
Elio Clemente Agostoni, Marco Longoni
Migraine is a common type of headache in young adults, with an estimated prevalence of 4% before puberty and as high as 25% in women by their mid to late 30s. About one third of migraineurs experience transient neurological symptoms known as auras, which characterize a variant known as migraine with aura. Many evidences have shown an increased risk of vascular events in patients affected by migraine, particularly among women and among migraine patients with aura. Potential underlying mechanisms include endothelial dysfunction, hypercoagulability, platelet aggregation, vasospasm, cardiovascular risk factors, paradoxical embolism, spreading depolarization, shared genetic risk, use of non-steroidal anti-inflammatory drugs, and immobilization...
June 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29901616/a-novel-dmd-splicing-mutation-found-in-a-family-responsible-for-x-linked-dilated-cardiomyopathy-with-hyper-ckemia
#7
Jin Tang, Xueqin Song, Guang Ji, Hongran Wu, Shuyan Sun, Shan Lu, Yuan Li, Chi Zhang, Huiqing Zhang
This study was aimed to detect a new mutation responsible for X-linked dilated cardiomyopathy with hyper-CKemia.We studied a proband who presented with cardiac symptoms with hyper-CKemia, but no clinical skeletal involvement in physical examination, laboratory tests, electromyography, echocardiography, and magnetic resonance imaging (MRI) of cardiac muscles. Muscle biopsy for histopathology and immunohistochemistry for accessing sarcolemma changes. The next-generation sequencing and bioinformatics analysis were performed on the patient and Sanger sequencing was confirmed on the other 6 unaffected families...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29898715/blind-blur-assessment-of-mri-images-using-parallel-multiscale-difference-of-gaussian-filters
#8
Michael E Osadebey, Marius Pedersen, Douglas L Arnold, Katrina E Wendel-Mitoraj
BACKGROUND: Rician noise, bias fields and blur are the common distortions that degrade MRI images during acquisition. Blur is unique in comparison to Rician noise and bias fields because it can be introduced into an image beyond the acquisition stage such as postacquisition processing and the manifestation of pathological conditions. Most current blur assessment algorithms are designed and validated on consumer electronics such as television, video and mobile appliances. The few algorithms dedicated to medical images either requires a reference image or incorporate manual approach...
June 13, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29897627/real-world-geographic-variations-in-the-use-of-cardiac-implantable-electronic-devices-the-panorama-2-observational-cohort-study
#9
Dirk Bastian, Iftikhar O Ebrahim, Ju-Yi Chen, Mien-Cheng Chen, Dejia Huang, Jin-Long Huang, Vadim A Kuznetsov, Bärbel Maus, Ajay M Naik, Koen J P Verhees, Ahmed R Al Fagih
BACKGROUND: Currently, several geographies around the world remain underrepresented in medical device trials. The PANORAMA 2 study was designed to assess contemporary region-specific differences in clinical practice patterns of patients with cardiac implantable electronic devices (CIEDs). METHODS: In this prospective, multicenter, observational, multi-national study, baseline and implant data of 4,706 patients receiving Medtronic CIEDs (either de novo device implants, replacements, or upgrades) were analyzed, consisting of: 54% implantable pulse generators (IPGs), 20...
June 13, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29896107/construction-and-validation-of-subject-specific-biventricular-finite-element-models-of-healthy-and-failing-swine-hearts-from-high-resolution-dt-mri
#10
Kevin L Sack, Eric Aliotta, Daniel B Ennis, Jenny S Choy, Ghassan S Kassab, Julius M Guccione, Thomas Franz
Predictive computational modeling has revolutionized classical engineering disciplines and is in the process of transforming cardiovascular research. This is particularly relevant for investigating emergent therapies for heart failure, which remains a leading cause of death globally. The creation of subject-specific biventricular computational cardiac models has been a long-term endeavor within the biomedical engineering community. Using high resolution (0.3 × 0.3 × 0.8 mm) ex vivo data, we constructed a precise fully subject-specific biventricular finite-element model of healthy and failing swine hearts...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29895299/association-between-abdominal-adiposity-and-subclinical-measures-of-left-ventricular-remodeling-in-diabetics-prediabetics-and-normal-controls-without-history-of-cardiovascular-disease-as-measured-by-magnetic-resonance-imaging-results-from-the-kora-ff4-study
#11
Christopher L Schlett, Roberto Lorbeer, Carolyn Arndt, Sigrid Auweter, Jürgen Machann, Holger Hetterich, Birgit Linkohr, Wolfgang Rathmann, Annette Peters, Fabian Bamberg
OBJECTIVES: Local, abdominal fat depots may be related to alterations in cardiac function and morphology due to a metabolic linkage. Thus, we aimed to determine their association with subtle cardiac changes and the potential interaction with hyperglycemic metabolic states. METHODS: Subjects from the general population and without history of cardiovascular disease were drawn from the Cooperative Health Research in the Region of Augsburg FF4 cohort and underwent 3 T cardiac and body MRI...
June 12, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29893997/changes-in-the-specific-absorption-rate-sar-of-radiofrequency-energy-in-patients-with-retained-cardiac-leads-during-mri-at-1-5t-and-3t
#12
Laleh Golestanirad, Amir Ali Rahsepar, John E Kirsch, Kenichiro Suwa, Jeremy C Collins, Leonardo M Angelone, Boris Keil, Rod S Passman, Giorgio Bonmassar, Peter Serano, Peter Krenz, Jim DeLap, James C Carr, Lawrence L Wald
PURPOSE: To evaluate the local specific absorption rate (SAR) and heating around retained cardiac leads during MRI at 64 MHz (1.5T) and 127 MHz (3T) as a function of RF coil type and imaging landmark. METHODS: Numerical models of retained cardiac leads were built from CT and X-ray images of 6 patients with retained cardiac leads. Electromagnetic simulations and bio-heat modeling were performed with MRI RF body and head coils tuned to 64 MHz and 127 MHz and positioned at 9 different imaging landmarks covering an area from the head to the lower limbs...
June 12, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29891833/x-linked-dilated-cardiomyopathy-presenting-as-acute-rhabdomyolysis-and-presumed-epstein-barr-virus-induced-viral-myocarditis-a-case-report
#13
Jacques A J Malherbe, Sue Davel
BACKGROUND Rhabdomyolysis and primary dilated cardiomyopathies without skeletal muscle weakness are rare features of X-linked dystrophinopathies. We report a rare case of an X-linked dilated cardiomyopathy (XLDCM) presenting with acute rhabdomyolysis and myocarditis. We illustrate the confounding diagnostic influence of a reactivated, persistent EBV myocarditis as the presumed cause for this patient's XLDCM. CASE REPORT A 23-year-old Australian man presented with acute rhabdomyolysis and elevated creatine kinase (CK) levels...
June 12, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29886573/severe-right-ventricular-hypertrophy-in-a-patient-with-extracardiac-and-intracardiac-shunt
#14
Mohit Pahuja, Aiden Abidov
Cardiac MRI is a complementary and confirmatory modality to a clinical echocardiography in diagnosing patients with complex adult congenital heart disease, especially in presence of great vessel abnormalities. We present a unique case of a patient with pulmonary hypertension (PH), severe right ventricular hypertrophy, Gerbode defect, and a large patent ductus arteriosus (PDA). The diagnosis of PDA was not visualized on prior serial echocardiograms and discovered on a comprehensive cardiac MRI/Chest MR angiogram...
June 10, 2018: Echocardiography
https://www.readbyqxmd.com/read/29886155/multi-organ-assessment-of-compensated-cirrhosis-patients-using-quantitative-magnetic-resonance-imaging
#15
Christopher R Bradley, Eleanor F Cox, Robert A Scott, Martin W James, Phillip Kaye, Guruprasad P Aithal, Susan T Francis, Indra Neil Guha
BACKGROUND AND AIMS: Advancing liver disease results in deleterious changes in a number of critical organs. The ability to measure structure, blood flow and tissue perfusion within multiple organs in a single scan has implications for determining the balance of benefit versus harm for therapies. Our aim was to establish the feasibility of Magnetic Resonance Imaging to assess changes in compensated cirrhosis (CC), and relate this to disease severity and future liver related outcomes (LROs)...
June 7, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29885824/myocardial-inflammation-detected-by-cardiac-mri-in-arrhythmogenic-right-ventricular-cardiomyopathy-a-paediatric-case-series
#16
Duarte Martins, Caroline Ovaert, Diala Khraiche, Nathalie Boddaert, Damien Bonnet, Francesca Raimondi
INTRODUCTION: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited myocardial disease with an elusive association with myocardial inflammation. A myocarditis phenotype has been well established without systematic evidence of a viral trigger. We intend to study the relationship between myocardial inflammation detected by Cardiac magnetic resonance (CMR) and ARVC in a paediatric population. METHODS: Retrospective case series of all patients <18 years admitted to two CMR units for clinical suspicion of myocarditis from March 2012 to June 2017 who had genetic testing for inherited cardiomyopathies including analysis for known ARVC genes...
May 31, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29883828/safety-of-dynamic-mri-of-the-cervical-spine-in-children-performed-without-neurosurgical-supervision
#17
Derek Yecies, Nathaniel Fogel, Michael Edwards, Gerald Grant, Kristen W Yeom, Samuel Cheshier
OBJECT: The need for neurosurgical supervision as well as the general safety and utility of dynamic MRI of the cervical spine in children remains controversial. We present the largest descriptive cohort study of cervical flexion-extension MRIs in a pediatric population to help elucidate the safety and utility of this technique. METHODS: All cervical spine MRIs performed at Lucile Packard Children's Hospital at Stanford from 2009-2015 were retrospectively reviewed...
June 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29881265/disconnection-of-pulmonary-and-systemic-arterial-stiffness-in-copd
#18
Jonathan R Weir-McCall, Patrick Sk Liu-Shiu-Cheong, Allan D Struthers, Brian J Lipworth, J Graeme Houston
Background: Both pulmonary arterial stiffening and systemic arterial stiffening have been described in COPD. The aim of the current study was to assess pulse wave velocity (PWV) within these two arterial beds to determine whether they are separate or linked processes. Materials and methods: In total, 58 participants with COPD and 21 healthy volunteers (HVs) underwent cardiac magnetic resonance imaging (MRI) and were tested with a panel of relevant biomarkers. Cardiac MRI was used to quantify ventricular mass, volumes, and pulmonary (pulse wave velocity [pPWV] and systemic pulse wave velocity [sPWV])...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29880624/unexpected-early-complication-of-implantable-cardioverter-defibrillator
#19
Ahmed Abdelhafez, Nancy Wassef, Kai Hogrefe, Mohsin Farooq
A 41-year-old woman was visiting Oxford, where she had a sudden cardiac arrest. Cardiopulmonary resuscitation was started by a bystander until the paramedics arrived, who found her in ventricular fibrillation, and delivered three shocks. After 28 min she had return of spontaneous circulation. Emergency coronary angiography revealed normal coronary arteries. Echocardiography followed by a cardiac MRI showed non-dilated left ventricles with no evidence of late gadolinium enhancement. She had a single-chamber implantable-cardioverter defibrillator (ICD)...
June 6, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29877162/experimental-spinal-cord-injury-causes-left-ventricular-atrophy-and-is-associated-with-an-upregulation-of-proteolytic-pathways
#20
Malihe-Sadat Poormasjedi-Meibod, Maral Mansouri, Mary Fossey, Jordan W Squair, Jie Liu, John H McNeill, Christopher R West
Spinal cord injury (SCI) causes autonomic dysfunction, altered neurohumoral control, profound hemodynamic changes, and an increased risk of heart disease. In this prospective study we investigated the cardiac consequences of chronic experimental SCI in rats by combining cutting edge in vivo techniques (magnetic resonance imaging (MRI) and left-ventricular (LV) pressure-volume catheterization) with histological and molecular assessments. 12 weeks post-SCI, MRI-derived structural indices and in vivo LV catheterization derived functional indices indicated the presence of LV atrophy (LV mass in Control vs...
June 7, 2018: Journal of Neurotrauma
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