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Stroke routing

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https://www.readbyqxmd.com/read/28317920/kus121-a-vcp-modulator-attenuates-ischemic-retinal-cell-death-via-suppressing-endoplasmic-reticulum-stress
#1
Masayuki Hata, Hanako O Ikeda, Chinami Kikkawa, Sachiko Iwai, Yuki Muraoka, Tomoko Hasegawa, Akira Kakizuka, Nagahisa Yoshimura
Ischemic neural damages cause several devastating diseases, including brain stroke and ischemic retinopathies, and endoplasmic reticulum (ER) stress has been proposed to be the underlying mechanism of the neuronal cell death of these conditions. We previously synthesized Kyoto University substances (KUSs) as modulators of valosin-containing protein (VCP); KUSs inhibit VCP ATPase activity and protect cells from different cell death-inducing insults. Here, we examined the efficacy of KUS121 in a rat model of retinal ischemic injury...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28301216/bioidentical-menopausal-hormone-therapy-registered-hormones-non-oral-estradiol%C3%A2-%C3%A2-%C3%A2-progesterone-are-optimal
#2
M L'Hermite
The many advantages of registered bioidentical sex hormones over registered, conventional, non-bioidentical menopausal hormone therapy (MHT) are considered. The transdermal route of estrogen administration avoids excess venous thromboembolic and ischemic stroke events. There is some indication that conjugated equine estrogens are more thrombogenic and most likely induce some hypertensive responses; estradiol might also be superior to conjugated equine estrogens (CEE) in terms of global cardiovascular health...
March 16, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28274581/learning-curves-among-all-patients-undergoing-transcatheter-aortic-valve-implantation-in-germany-a-retrospective-observational-study
#3
Klaus Kaier, Holger Reinecke, Claudia Schmoor, Lutz Frankenstein, Werner Vach, Philip Hehn, Andreas Zirlik, Christoph Bode, Manfred Zehender, Jochen Reinöhl
BACKGROUND: Transcatheter aortic valve implantation (TAVI) is a rapidly evolving technique for therapy of aortic stenosis. Previous studies report learning curves with respect to in-hospital mortality and clinical complications. We aim to determine whether observed improvements of in-hospital outcomes after TAVI are the result of improvements in procedures or due to a change in the patient population, and whether improvements differ between the transfemoral (TF) and the transapical (TA) approach...
March 2, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28274520/the-carotid-artery-as-a-preferred-alternative-access-route-for-transcatheter-aortic-valve-replacement
#4
Eric B Kirker, Robert W Hodson, Kateri J Spinelli, Ethan C Korngold
BACKGROUND: In high-risk patients with severe aortic stenosis, transfemoral (TF) access for transcatheter aortic valve replacement (TAVR) is the preferred access route but is not always feasible. Compared with other alternative access routes, transcarotid (TC) access is often overlooked by many valvular heart teams. METHODS: We report our single-center experience of all patients undergoing TC (n = 25), transapical (TA) (n = 12), or TF (n = 100; limited to most recent cases) TAVR over a 1...
March 5, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28273724/imaging-angiogenesis-using-68-ga-nota-prgd2-positron-emission-tomography-computed-tomography-in-patients-with-severe-intracranial-atherosclerotic-disease
#5
Shi Shu, Li Zhang, Yi Cheng Zhu, Fang Li, Li Ying Cui, Hao Wang, Yi Sun, Pei Lin Wu, Zhao Hui Zhu, Bin Peng
Angiogenesis is a critical compensation route, which has been demonstrated in the brain following ischemic stroke; however, few studies have investigated angiogenesis in chronic intracranial atherosclerosis disease (ICAD). We used (68)Ga-NOTA-PRGD2 positron emission tomography/computed tomography based imaging to detect angiogenesis in chronic ICAD and to explore the factors that may have affected it. A total of 21 participants with unilateral severe chronic ICAD were included in the study. Of the 21 participants, 19 were men; the mean (SD) age was 52 (15) years...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28242552/enzymatic-and-solid-phase-synthesis-of-new-donepezil-based-l-and-d-glutamic-acid-derivatives-and-their-pharmacological-evaluation-in-models-related-to-alzheimer-s-disease-and-cerebral-ischemia
#6
Leticia Monjas, Mariana P Arce, Rafael León, Javier Egea, Concepción Pérez, Mercedes Villarroya, Manuela G López, Carmen Gil, Santiago Conde, María Isabel Rodríguez-Franco
Previously, we have described N-Bz-L-Glu[NH-2-(1-benzylpiperidin-4-yl)ethyl]-O-nHex (IQM9.21, L-1) as an interesting multifunctional neuroprotective compound for the potential treatment of neurodegenerative diseases. Here, we describe new derivatives and different synthetic routes, such as chemoenzymatic and solid-phase synthesis, aiming to improve the previously described route in solution. The lipase-catalysed amidation of L- and D-Glu diesters with N-benzyl-4-(2-aminoethyl)piperidine has been studied, using Candida antarctica and Mucor miehei lipases...
April 21, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28217983/extraction-and-separation-of-lactate-dehydrogenase-inhibitors-from-poria-cocos-schw-wolf-based-on-a-hyphenated-technique-and-in-vitro-methods
#7
Sainan Li, Jianxu Zhang, Senlin Li, Chunming Liu, Shu Liu, Zhiqiang Liu
Stroke is one of the most common diseases worldwide. Lactate dehydrogenase inhibitors are widely used in the treatment of ischemic stroke, with natural products considered a promising source of lactate dehydrogenase inhibitors. In this study, ultrafiltration liquid chromatography coupled with mass spectrometry was used for the screening and identification of lactate dehydrogenase inhibitors from Poria cocos. Five lactate dehydrogenase inhibitors were selected: dehydropachymic acid, pachymic acid, dehydrotrametenolic acid, trametenolic acid, and eburicoic acid...
February 20, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28214578/increasing-lateralized-motor-activity-in-younger-and-older-adults-using-real-time-fmri-during-executed-movements
#8
Heather F Neyedli, Cassandra Sampaio-Baptista, Matthew A Kirkman, David Havard, Michael Lührs, Katie Ramsden, David D Flitney, Stuart Clare, Rainer Goebel, Heidi Johansen-Berg
Neurofeedback training involves presenting an individual with a representation of their brain activity and instructing them to alter the activity using the feedback. One potential application of neurofeedback is for patients to alter neural activity to improve function. For example, there is evidence that greater laterality of movement-related activity is associated with better motor outcomes after stroke; so using neurofeedback to increase laterality may provide a novel route for improving outcomes. However, we must demonstrate that individuals can control relevant neurofeedback signals...
February 15, 2017: Neuroscience
https://www.readbyqxmd.com/read/28154249/innovations-in-liposomal-dds-technology-and-its-application-for-the-treatment-of-various-diseases
#9
REVIEW
Naoto Oku
Liposomes have been widely used as drug carriers in the field of drug delivery systems (DDS), and they are thought to be ideal nano-capsules for targeting DDS after being injected into the bloodstream. In general, DDS drugs meet the needs of aged and super-aged societies, since the administration route of drugs can be changed, the medication frequency reduced, the adverse effects of drugs suppressed, and so on. In fact, a number of liposomal drugs have been launched and used worldwide including liposomal anticancer drugs, and these drugs have appeared on the market owing to various innovations in liposomal DDS technologies...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28134488/bioactivity-screening-extraction-and-separation-of-lactate-dehydrogenase-inhibitors-from-polygala-tenuifolia-willd-based-on-a-hyphenated-strategy
#10
Sainan Li, Shu Liu, Zhiqiang Liu, Chunming Liu, Fengrui Song, Zifeng Pi
Stroke is the second leading cause of death worldwide. Lactate dehydrogenase inhibitors are currently widely used in the treatment of ischemic stroke, and natural products are considered promising sources of lactate dehydrogenase inhibitors. In this study, ultrafiltration liquid chromatography coupled with mass spectrometry was used for the screening and identification of lactate dehydrogenase inhibitors from Polygala tenuifolia. Furthermore, five lactate dehydrogenase inhibitors, sibiricose A5, 3,6'-di-O-sinapoyl-sucrose, glomeratose A, tenuifoliside B, and tenuifoliside C, were selected as target lactate dehydrogenase inhibitors...
March 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28103788/pharmacokinetics-metabolism-and-disposition-of-14c-xq-1h-after-intravenous-administration-to-male-rats
#11
Yinlin Qin, Tao Chen, Qiu Jin, Kai Guo, Hao Feng, Dennis Heller, Zheming Gu
This study describes the in vivo pharmacokinetics and metabolism of [14C]labeled XQ-1H in male rats. XQ-1H is a methanesulfonate of XQ, 10-O-(N,N-dimethylaminoethyl)-ginkgolide B is a derivative of ginkgolide B (GB) with enhanced water solubility. Since it is very difficult to synthesize radiolabeled GB, the results obtained in this study may provide helpful insight to further ADME investigation of GB and its analogue compounds. After an i.v. administration of [14C]XQ-1H to male rats, XQ (the freebase form of XQ-1H) was extensively hydrolyzed, moderately metabolized, and mainly excreted in feces (71...
January 18, 2017: Drug Metabolism Letters
https://www.readbyqxmd.com/read/28093732/long-term-hormone-therapy-for-perimenopausal-and-postmenopausal-women
#12
REVIEW
Jane Marjoribanks, Cindy Farquhar, Helen Roberts, Anne Lethaby, Jasmine Lee
BACKGROUND: Hormone therapy (HT) is widely provided for control of menopausal symptoms and has been used for the management and prevention of cardiovascular disease, osteoporosis and dementia in older women. This is an updated version of a Cochrane review first published in 2005. OBJECTIVES: To assess effects of long-term HT (at least 1 year's duration) on mortality, cardiovascular outcomes, cancer, gallbladder disease, fracture and cognition in perimenopausal and postmenopausal women during and after cessation of treatment...
January 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28091591/intraarterial-route-increases-the-risk-of-cerebral-lesions-after-mesenchymal-cell-administration-in-animal-model-of-ischemia
#13
Bárbara Argibay, Jesse Trekker, Uwe Himmelreich, Andrés Beiras, Antonio Topete, Pablo Taboada, María Pérez-Mato, Alba Vieites-Prado, Ramón Iglesias-Rey, José Rivas, Anna M Planas, Tomás Sobrino, José Castillo, Francisco Campos
Mesenchymal stem cells (MSCs) are a promising clinical therapy for ischemic stroke. However, critical parameters, such as the most effective administration route, remain unclear. Intravenous (i.v.) and intraarterial (i.a.) delivery routes have yielded varied outcomes across studies, potentially due to the unknown MSCs distribution. We investigated whether MSCs reached the brain following i.a. or i.v. administration after transient cerebral ischemia in rats, and evaluated the therapeutic effects of both routes...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28077091/transradial-versus-transfemoral-approach-for-coronary-angiography-and-angioplasty-a-prospective-randomized-comparison
#14
Fayaz Ahmad Bhat, Khalid Hamid Changal, Hameed Raina, Nisar Ahmad Tramboo, Hilal Ahmad Rather
BACKGROUND: PCI has been done traditionally through transfemoral route. But now transradial and transbrachial routes are also coming up in practice. We compared transradial versus transfemoral routes for ease of operability, time for procedure, complications, and failure rates through a prospective study. METHODS: Four hundred Patients admitted in department of cardiology for percutaneous interventions were enrolled in the study. 200 patients were assigned to each group randomly...
January 11, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28055998/-hypertensive-crisis-urgency-and-hypertensive-emergency
#15
Javier Sobrino Martínez, Mónica Doménech Feria-Carot, Alberto Morales Salinas, Antonia Coca Payeras
Hypertensive crises lumped several clinical situations with different seriousness and prognosis. The differences between hypertensive urgency and hypertensive emergency depends on if this situation involves a vital risk for the patient. This risk is defined more by the severity of the organ damage than for the higher values of blood pressure. The hypertensive urgency not involves an immediately risk for the patient, for these reason, the treatment can be completed after discharged. Otherwise, the hypertensive emergency is a critical clinical condition that requires hospital assistance...
November 18, 2016: Medwave
https://www.readbyqxmd.com/read/28017253/therapeutic-route-of-patients-at-the-acute-phase-of-their-stroke-in-burkina-faso
#16
Christian Napon, Anselme Dabilgou, Julie Kyelem, Papougnézambo Bonkoungou, Jean Kaboré
INTRODUCTION: The advent of the neurovascular units and thrombolysis has improved support for stroke in developed countries. Our objective was to study the therapeutic route of stroke patients in Burkina Faso, a country with limited resources. METHODS: It was a prospective cohort study over a period of 4months, from February 02, 2014 to June 05, 2014, in medical emergencies and Neurology department of the teaching hospital Yalgado Ouedraogo. The study focused on patients diagnosed with stroke through brain imaging when they first entered hospital or during hospitalization...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27956600/revealing-the-dual-streams-of-speech-processing
#17
Julius Fridriksson, Grigori Yourganov, Leonardo Bonilha, Alexandra Basilakos, Dirk-Bart Den Ouden, Christopher Rorden
Several dual route models of human speech processing have been proposed suggesting a large-scale anatomical division between cortical regions that support motor-phonological aspects vs. lexical-semantic aspects of speech processing. However, to date, there is no complete agreement on what areas subserve each route or the nature of interactions across these routes that enables human speech processing. Relying on an extensive behavioral and neuroimaging assessment of a large sample of stroke survivors, we used a data-driven approach using principal components analysis of lesion-symptom mapping to identify brain regions crucial for performance on clusters of behavioral tasks without a priori separation into task types...
December 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27928655/in-vivo-pharmacokinetics-of-puerarin-via-different-drug-administration-routes-based-on-middle-cerebral-artery-occlusion-model
#18
Pengyue Li, Jie Bai, Boyu Dong, Yang Lu, Shengwei Zhang, Shuang Guo, Ning Tan, Mengdi Zhao, Shouying Du, Puning Cao
BACKGROUND AND OBJECTIVES: Pueraria labata has traditionally been applied in the treatment of stroke in Chinese clinics. Puerarin is the key ingredient in it for brain protection effect. To find a superior administration route for puerarin in the treatment of ischemic cerebrovascular disease, the pharmacokinetics of puerarin based on the middle cerebral artery occlusion (MCAO) rat via different administration routes were studied and compared. METHODS: Ten rats (MCAO model) divided into two groups were treated with puerarin via intravenous and intranasal routes...
December 7, 2016: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/27856228/mesenchymal-stromal-cell-secretomes-are-modulated-by-suspension-time-delivery-vehicle-passage-through-catheter-and-exposure-to-adjuvants
#19
Kaushik Parsha, Osman Mir, Nikunj Satani, Bing Yang, Waldo Guerrero, Zhuyong Mei, Chunyan Cai, Peng R Chen, Adrian Gee, Patrick J Hanley, Jaroslaw Aronowski, Sean I Savitz
BACKGROUND AIMS: Extensive animal data indicate that mesenchymal stromal cells (MSCs) improve outcome in stroke models. Intra-arterial (IA) injection is a promising route of delivery for MSCs. Therapeutic effect of MSCs in stroke is likely based on the broad repertoire of secreted trophic and immunomodulatory cytokines produced by MSCs. We determined the differential effects of exposing MSCs to different types of clinically relevant vehicles, and/or different additives and passage through a catheter relevant to IA injections...
January 2017: Cytotherapy
https://www.readbyqxmd.com/read/27815174/comparative-biodistribution-and-safety-profiling-of-olmesartan-medoxomil-oil-in-water-oral-nanoemulsion
#20
COMPARATIVE STUDY
Bapi Gorain, Hira Choudhury, Rakesh Kumar Tekade, Saumen Karan, P Jaisankar, Tapan Kumar Pal
Poor aqueous solubility and unfavourable de-esterification of olmesartan medoxomil (a selective angiotensin II receptor blocker), results in low oral bioavailability of less than 26%. Improvement of oral bioavailability with prolonged pharmacodynamics activity of olmesartan in Wistar rats had been approached by nanoemulsification strategy in our previous article [Colloid Surface B, 115, 2014: 286]. In continuation to that work, we herewith report the biodistribution behaviour and 28-day repeated dose sub-chronic toxicity of olmesartan medoxomil nanoemulsion in Wistar rats following oral administration...
December 2016: Regulatory Toxicology and Pharmacology: RTP
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