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Cardiac SPECT

Sang-Geon Cho, Zeenat Jabin, Ki Seong Park, Jahae Kim, Sae-Ryung Kang, Seong Young Kwon, Geum-Cheol Jeong, Minchul Song, Jong Sang Kim, Jae Yeong Cho, Hyun Kuk Kim, Ho-Chun Song, Jung-Joon Min, Hee-Seung Bom
PURPOSE: The aim of this study was to evaluate the prognostic value of additional evaluation of left ventricular mechanical dyssynchrony (LVMD) by gated myocardial perfusion single-photon emission computed tomography (GMPS) in patients with acute myocardial infarction (MI) and multivessel disease. METHODS: One hundred and nine acute MI patients with >50 % stenosis in at least one non-culprit artery who underwent GMPS within 2 weeks were enrolled. All patients underwent successful revascularization of the culprit arteries...
October 18, 2016: European Journal of Nuclear Medicine and Molecular Imaging
Ana Abreu, Helena Santa Clara
Cardiac resynchronization therapy (CRT) is an established treatment for patients with moderate-to-severe chronic heart failure (CHF) and intraventricular conduction delay, which is identified by a QRS interval of 120msec or more on a 12-lead electrocardiogram (ECG). CRT improved functional capacity, reduced hospitalizations for worsening CHF and increased survival. However, about 30-40% of patients who underwent CRT were non-responders with no clinical or echocardiographic improvement. Imaging parameters for prediction of CRT response have been reviewed...
October 14, 2016: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
Mark Doyle, Gerald M Pohost, C Noel Bairey Merz, Leslee J Shaw, George Sopko, William J Rogers, Barry L Sharaf, Carl J Pepine, Diane V Thompson, Geetha Rayarao, Lindsey Tauxe, Sheryl F Kelsey, Robert W W Biederman
BACKGROUND: We introduce an algorithmic approach to optimize diagnostic and prognostic value of gated cardiac single photon emission computed tomography (SPECT) and magnetic resonance (MR) myocardial perfusion imaging (MPI) modalities in women with suspected myocardial ischemia. The novel approach: bio-informatics assessment schema (BIAS) forms a mathematical model utilizing MPI data and cardiac metrics generated by one modality to predict the MPI status of another modality. The model identifies cardiac features that either enhance or mask the image-based evidence of ischemia...
October 2016: Cardiovascular Diagnosis and Therapy
Adam Ali Ghotbi, Andreas Kjaer, Lars Nepper-Christensen, Kiril Aleksov Ahtarovski, Jacob Thomsen Lønborg, Niels Vejlstrup, Kasper Kyhl, Thomas Emil Christensen, Thomas Engstrøm, Henning Kelbæk, Lene Holmvang, Lia E Bang, Rasmus Sejersten Ripa, Philip Hasbak
BACKGROUND: Determining infarct size and myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI) is important when assessing the efficacy of new reperfusion strategies. We investigated whether rest (82)Rb-PET myocardial perfusion imaging can estimate area at risk, final infarct size, and myocardial salvage index when compared to cardiac SPECT and magnetic resonance (CMR). METHODS: Twelve STEMI patients were injected with (99m)Tc-Sestamibi intravenously immediate prior to reperfusion...
October 14, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Guido Germano, Paul B Kavanagh, Terrence D Ruddy, R Glenn Wells, Yuan Xu, Daniel S Berman, Piotr J Slomka
OBJECTIVES: This paper investigates the ability of grouped quantification (an expression of the same-patient processing approach, or SPP) to improve repeatability of measurements in patients with multiple SPECT studies, and evaluates its performance compared to standard quantification in a population of 100 patients undergoing rest, stress, gated rest, and gated stress SPECT MPI. All acquisitions were performed twice, back-to-back, for a total of 800 image datasets (8 per patient). METHODS: Each dataset was automatically processed (a) independently, using standard quantitative software, and (b) as a group, together with the other 7 datasets belonging to the same patient, using an SPP-modified version of the software that registered the images to one another using a downhill simplex algorithm for the search of optimal translation, rotation, and scaling parameters...
October 14, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Guido Germano, Paul B Kavanagh, Mathews B Fish, Mark H Lemley, Yuan Xu, Daniel S Berman, Piotr J Slomka
OBJECTIVES: This paper describes a novel approach (same-patient processing, or SPP) aimed at improving left ventricular segmentation accuracy in patients with multiple SPECT studies, and evaluates its performance compared to conventional processing in a large population of 962 patients undergoing rest and stress electrocardiography-gated SPECT MPI, for a total of 5,772 image datasets (6 per patient). METHODS: Each dataset was independently processed using a standard algorithm, and a shape quality control score (SQC) was produced for every segmentation...
October 14, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Federico Ferrando-Castagnetto, Roberto Ricca-Mallada, Alejandro Vidal, Fabián Martínez, Rodolfo Ferrando
Pacemaker stimulation is associated with unpredictable severe cardiac events. We evaluated left ventricular mechanical dyssynchrony (LVMD) during prolonged septal right ventricular pacing. We performed 99mTc-MIBI gated-SPECT and phase analysis in 6 patients with pacemakers implanted at least one year before scintigraphy due to advanced atrioventricular block. Using V-Sync of Emory Cardiac Toolbox we obtained phase bandwidth (PBW) and standard deviation (PSD) from rest phase histogram. Clinical variables, QRS duration, rate and mode of pacing in septal right ventricle wall, chamber diameters, presence and extension of myocardial scar and ischemia and rest LVEF were recorded...
2016: Medicina
Jean-François Sarrazin, François Philippon, Mikaël Trottier, Michel Tessier
Cardiovascular implantable electronic device (CIED) infection and prosthetic valve endocarditis (PVE) remain a diagnostic challenge. Cardiac imaging plays an important role in the diagnosis and management of patients with CIED infection or PVE. Over the past few years, cardiac radionuclide imaging has gained a key role in the diagnosis of these patients, and in assessing the need for surgery, mainly in the most difficult cases. Both (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) and radiolabelled white blood cell single-photon emission computed tomography/computed tomography (WBC SPECT/CT) have been studied in these situations...
September 26, 2016: World Journal of Cardiology
Elsemiek M Engbers, Jorik R Timmer, Jan Paul Ottervanger, Mohamed Mouden, Siert Knollema, Pieter L Jager
The coronary artery calcium (CAC) score provides independent prognostic value on top of single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). We sought to determine whether the prognostic value of the CAC score in patients with normal SPECT MPI is gender specific. We studied 3,705 consecutive symptomatic patients without a history of coronary artery disease with normal SPECT MPI. All patients underwent concomitant CAC scoring, which was categorized as CAC score 0, 1 to 99, 100 to 399, 400 to 999, or ≥1,000...
August 30, 2016: American Journal of Cardiology
Maria Salsone, Rita Nistico', Basilio Vescio, Fabiana Novellino, Maurizio Morelli, Angela Lupo, Gennarina Arabia, Aldo Quattrone
OBJECTIVE: To investigate heart rate variability (HRV) in patients with Essential Tremor (ET) in comparison with patients with Parkinson's Disease (PD). METHODS: This is a cross sectional control study including 10 patients with ET, 10 patients with PD and 10 age-sex-matched controls. In patients and controls, we measured the components of HRV analysis in the frequency domain during a daytime period of 12-h. Selected HRV variables were low-frequency (LF) and high-frequency (HF), conventionally considered to be influenced by the sympathetic system and the parasympathetic system respectively...
September 28, 2016: Parkinsonism & related Disorders
Marine Claudin, Laetitia Imbert, Wassila Djaballah, Nicolas Veran, Sylvain Poussier, Véronique Roch, Mathieu Perrin, Antoine Verger, Henri Boutley, Gilles Karcher, Pierre-Yves Marie
PURPOSE: Gamma-cameras, with Cadmium-Zinc-Telluride (CZT) detectors, allow to perform myocardial perfusion imaging (MPI) with limited injected activities and recorded times. This study aimed at determining whether the routine assessment of left ventricular (LV) function with such limited counts protocols compares well with reference values from cardiac MRI. METHODS: The study included patients who have undergone cardiac MRI and an MPI routinely planned on a CZT camera with a low-dose protocol (120 MBq of Sestamibi for stress and 360 MBq at rest for 75 kg body weight), while targeting the recording of only 500 myocardial kcounts in order to limit the recording times (<10 minutes for stress, <4 minutes for rest)...
September 27, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Wael Abuzeid, Robert M Iwanochko, Xuesong Wang, S Joseph Kim, Mansoor Husain, Douglas S Lee
BACKGROUND: While renal transplantation is increasingly performed for end-stage renal disease, there is a paucity of data on cardiac screening and prognostication post-transplant. We determined the prognostic value of SPECT-MPI in a cohort who underwent renal transplantation. METHODS: Among 4933 renal transplant recipients identified from the Canadian Organ Replacement Register, we examined outcomes of patients who underwent SPECT-MPI in Ontario, Canada. We determined morbidity and mortality using hospitalization and vital statistics registries, according to SPECT-MPI findings...
September 23, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Konstantin V Zavadovsky, Victor V Saushkin, Mikhail S Khlynin, Sergey V Popov, Yuri B Lishmanov
BACKGROUND: The aim of the study was to evaluate the impact of idiopathic ventricular tachycardia and premature ventricular beats on cardiac function and dyssynchrony and to elucidate relationships between data of scintigraphic and intracardiac electrophysiology studies. METHODS: The study comprised 64 patients with idiopathic ventricular arrhythmias (VA) (median age of 14 years ranging from 8 to 18 years). Control group comprised 20 patients (median age of 12 ranging from 7 to 16 years) without cardiac arrhythmias...
September 23, 2016: Pacing and Clinical Electrophysiology: PACE
Carmine Siniscalchi, Claudio Reverberi, Nicola Gaibazzi
BACKGROUND AND AIM: Individuals with ischemia during cardiac stress-test (cST) have a high risk of developing myocardial infarction (MI), but the pathophysiologic mechanism has never been clarified. It is thought that non flow-limiting coronary plaques (FLP) cause more often MI than FLP, but this is in contradiction with the predictive value of cST. We investigated the correspondence between reversible ischemia and location of subsequent MI, since functional assessment shortly before MI could clarify whether the culprit plaque is a FLP or not...
2016: Acta Bio-medica: Atenei Parmensis
Arthur E Stillman, Constantine Gatsonis, João A C Lima, William C Black, Jean Cormack, Ilana Gareen, Udo Hoffmann, Tao Liu, Kreton Mavromatis, Mitchell D Schnall, James E Udelson, Pamela K Woodard
RESCUE is a phase III, randomized, controlled, multicenter, comparative efficacy study, designed to compare two diagnostic imaging/treatment paradigms that use coronary computed tomography angiography (CCTA) or single photon emission computed tomography myocardial perfusion imaging (SPECT MPI) for assisting in the diagnosis of ischemic heart disease in patients with stable angina symptoms, and guiding subsequent treatment. The study is based on the hypothesis that CCTA as a diagnostic tool is associated with no increase in cardiac risk, decreased cost, and reduced radiation exposure compared with SPECT MPI...
September 2016: American Heart Journal
Chung Chan, Hui Liu, Yariv Grobshtein, Mitchel R Stacy, Albert J Sinusas, Chi Liu
PURPOSE: Partial volume correction (PVC) methods typically improve quantification at the expense of increased image noise and reduced reproducibility. In this study, the authors developed a novel voxel-based PVC method that incorporates anatomical knowledge to improve quantification while suppressing noise for cardiac SPECT/CT imaging. METHODS: In the proposed method, the SPECT images were first reconstructed using anatomical-based maximum a posteriori (AMAP) with Bowsher's prior to penalize noise while preserving boundaries...
September 2016: Medical Physics
Gary L Murray, Joseph Colombo
High sympathetic tone and cardiac autonomic neuropathy (CAN) are associated with major adverse cardiac events (MACE). We have shown ranolazine (RAN) improves autonomic function. RAN was introduced to 51 successive anginal CD patients (RANCD). A control group of 54 successive nonanginal CD patients (NORANCD) continued baseline therapy. Mean study duration was 6.1 years, which included semi-annual autonomic function measures (ANX 3.0, ANSAR Medical Technologies, Inc., Philadelphia, PA) and yearly myocardial perfusion SPECT studies (MPI)...
September 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
Diana Paez, Amalia Peix, Pilar Orellana, Joao Vitola, Fernando Mut, Claudia Gutiérrez, Crosby Plaza, Tarik Becic, Maurizio Dondi, Enrique Estrada
The burden of cardiovascular diseases (CVDs) in the world is ever growing. They represent the first cause of death worldwide and in Latin America. Nuclear cardiology has a well-established role in the management of patient with CVDs and is being increasingly integrated into the healthcare systems in the region. However, there remains variability as to the infrastructure available across the countries, in terms of existing technology, radiopharmaceuticals, and human resources. The approximate number of gamma (γ) cameras in the region is 1348, with an average of 2...
August 29, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Romain Clerc, Sophia Doll, Laurent M Riou, Pascale Perret, Alexis Broisat, Audrey Soubies, Marie-Dominique Desruet, Daniel Fagret, Carole Schwebel, Catherine Ghezzi
BACKGROUND: Sympathetic system abnormalities have been reported in sepsis-related cardiac dysfunction. The present study aimed at evaluating the potential of the norepinephrine radiolabeled analogue [(123)I]-meta-iodobenzylguanidine ((123)I-MIBG) for the noninvasive assessment of modifications in cardiac sympathetic activity occurring in lipopolysaccharide (LPS)-induced experimental acute sepsis by single-photon emission computed tomographic imaging (SPECT). METHODS AND RESULTS: Sepsis was induced in male Wistar rats by intraperitoneal injection of 10 mg·kg(-1) lipopolysaccharide (n = 16), whereas control animals (n = 7) were injected with vehicle (NaCl 0...
August 29, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Svetlana I Sazonova, Julia N Ilyushenkova, Yuri B Lishmanov, Roman E Batalov, Alexey E Sazonov, Ludmila A Larionova, Evgeniy A Nesterov, Natalia V Varlamova, Julia V Rogovskaya, Tatyana A Shelkovnikova, Sergey V Popov
OBJECTIVE: Aim was to study the performance of single-photon emission computed tomography (SPECT) with (99m)Tc-pyrophosphate ((99m)Tc-PYP) in diagnostics of chronic latent inflammation in myocardium of patients with atrial fibrillation (AF). METHODS: The research included 70 patients (the average age of 49.3 ± 10.2 years) with persistent form of idiopathic AF. All patients underwent myocardium SPECT with (99m)Tc-PYP and cardiac magnetic resonance imaging (CMR) before the ablation...
August 24, 2016: Annals of Nuclear Medicine
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