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Cardiac SPECT

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https://www.readbyqxmd.com/read/28936780/ct-based-spect-attenuation-correction-and-assessment-of-infarct-size-results-from-a-cardiac-phantom-study
#1
Alexander Stephan Kroiss, Stephan Gerhard Nekolla, Georg Dobrozemsky, Thomas Grubinger, Barry Lynn Shulkin, Markus Schwaiger
RATIONALE: Myocardial perfusion SPECT is a commonly performed, well established, clinically useful procedure for the management of patients with coronary artery disease. However, the attenuation of photons from myocardium impacts the quantification of infarct sizes. CT-Attenuation Correction (AC) potentially resolves this problem. This contention was investigated by analyzing various parameters for infarct size delineation in a cardiac phantom model. METHODS: A thorax phantom with a left ventricle (LV), fillable defects, lungs, spine and liver was used...
September 21, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28924814/the-prognostic-value-of-heart-rate-response-during-vasodilator-stress-myocardial-perfusion-imaging-in-patients-with-end-stage-renal-disease-undergoing-renal-transplantation
#2
Wael AlJaroudi, Chiedozie Anokwute, Ibtihaj Fughhi, Tania Campagnoli, Marwan Wassouf, Aviral Vij, Michael Kharouta, Andrew Appis, Amjad Ali, Rami Doukky
BACKGROUND: In asymptomatic end-stage renal disease (ESRD) patients undergoing vasodilator stress myocardial perfusion imaging (MPI) prior to renal transplantation (RT), the impact of pre-transplant heart rate response (HRR) to vasodilator stress on post-RT outcomes is unknown. METHODS: We analyzed a retrospective cohort of asymptomatic patients with ESRD who underwent a vasodilator stress SPECT-MPI and subsequently received RT. Blunted HRR was defined as HRR <28% for regadenoson stress and <20% for adenosine stress...
September 18, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28923324/regenerating-heart-using-a-novel-compound-and-human-wharton-jelly-mesenchymal-stem-cells
#3
Shahram Rabbani, Masoud Soleimani, Mohammad Imani, Mohammad Sahebjam, Ali Ghiaseddin, Seyed Mahdi Nassiri, Jalil Majd Ardakani, Maryam Tajik Rostami, Arash Jalali, Bahmanshir Mousanassab, Mahsa Kheradmandi, Seyed Hossein Ahmadi Tafti
BACKGROUND: Myocardial infarction is a major problem in health system and most conventional therapy is not led to restoration of the health. Stem cell therapy is a method to regenerate the heart but today appropriate cell source and scaffold selection as extracellular matrix to achieve the best effect is disputing. AIM OF THE STUDY: In this study a combination of human Wharton jelly mesenchymal stem cells (HWJMSCs) with a novel compound consisting polyethylene glycol (PEG), hyaluronic acid and chitosan is presented to heart regeneration...
April 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28917675/regional-variation-in-technetium-pyrophosphate-uptake-in-transthyretin-cardiac-amyloidosis-and-impact-on%C3%A2-mortality
#4
Brett W Sperry, Michael N Vranian, Albree Tower-Rader, Rory Hachamovitch, Mazen Hanna, Richard Brunken, Dermot Phelan, Manuel D Cerqueira, Wael A Jaber
OBJECTIVES: This study sought to investigate the regional uptake of technetium 99m-pyrophosphate (TcPYP) in transthyretin cardiac amyloidosis (ATTR) and its association with mortality. BACKGROUND: TcPYP nuclear scintigraphy is a diagnostic and prognostic tool in ATTR. Echocardiography has identified a pattern of regional variation in longitudinal strain (LS) with a gradient of improved strain from base to apex in ATTR. METHODS: Consecutive patients with ATTR were evaluated who underwent TcPYP nuclear scintigraphy with planar and attenuation corrected single-photon emission computed tomography (SPECT)...
September 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28917674/prognostic-value-of-risk-factors-calcium%C3%A2-score-coronary-cta-myocardial%C3%A2-perfusion-imaging-and-invasive%C3%A2-coronary-angiography-in-kidney%C3%A2-transplantation-candidates
#5
Simon Winther, My Svensson, Hanne Skou Jørgensen, Laust Dupont Rasmussen, Niels Ramsing Holm, Lars Christian Gormsen, Kirsten Bouchelouche, Hans Erik Bøtker, Per Ivarsen, Morten Bøttcher
OBJECTIVES: This study sought to perform a prospective head-to-head comparison of the predictive value of clinical risk factors and a variety of cardiac imaging modalities including coronary artery calcium score (CACS), coronary computed tomography angiography (CTA), single-photon emission computed tomography (SPECT), and invasive coronary angiography (ICA) on major adverse cardiac events (MACE) and all-cause mortality in kidney transplantation candidates. BACKGROUND: Current guidelines recommend screening for coronary artery disease in kidney transplantation candidates...
September 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28916622/quantification-and-determination-of-normal-123-i-meta-iodobenzylguanidine-heart-to-mediastinum-ratio-hmr-from-cardiac-spect-ct-and-correlation-with-planar-hmr
#6
Raza Alvi, Edward J Miller, Taraneh Hashemi Zonouz, Veronica Sandoval, Noor Tariq, Rachel Lampert, Albert J Sinusas, Yi-Hwa Liu
Assessment of cardiac (123)I-mIBG uptake relies on the heart-to-mediastinal ratio (HMR) derived from planar images. We have developed novel semi-automated quantitative methodologies for assessing HMR from single photon emission computed tomography (SPECT) images using a dedicated cardiac multi-pinhole SPECT/computerized tomography (CT) system and determined the lower limit of normal (LLN) SPECT-derived HMR and the correlation to planar-derived HMR. Methods: Twenty-one healthy volunteers were injected with (123)I-meta Iodobenzylguanidine ((123)I-mIBG) and imaged using two different cameras...
September 15, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28905088/new-horizons-in-cardiac-innervation-imaging-introduction-of-novel-18-f-labeled-pet-tracers
#7
Ryohei Kobayashi, Xinyu Chen, Rudolf A Werner, Constantin Lapa, Mehrbod S Javadi, Takahiro Higuchi
Cardiac sympathetic nervous activity can be uniquely visualized by non-invasive radionuclide imaging techniques due to the fast growing and widespread application of nuclear cardiology in the last few years. The norepinephrine analogue (123)I-meta-iodobenzylguanidine ((123)I-MIBG) is a single photon emission computed tomography (SPECT) tracer for the clinical implementation of sympathetic nervous imaging for both diagnosis and prognosis of heart failure. Meanwhile, positron emission tomography (PET) imaging has become increasingly attractive because of its higher spatial and temporal resolution compared to SPECT, which allows regional functional and dynamic kinetic analysis...
September 13, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28865679/quantification-of-myocardial-perfusion-reserve-using-dynamic-spect-images-of-patients-with-chronic-kidney-disease
#8
Noriko Tsuda, Shinya Shiraishi, Fumi Sakamoto, Hideaki Yuki, Koji Ogasawara, Morikatsu Yoshida, Seiji Tomiguchi, Kenichi Tsujita, Yasuyuki Yamashita
BACKGROUND: Chronic kidney disease (CKD) is an independent risk factor for cardiovascular disorders. The aim of this study was to examine whether the quantitatively measured myocardial blood flow (MBF) or myocardial perfusion reserve (MPR), calculated by dynamic single photon emission computed tomography (SPECT) analysis using a cardiac cadmium zinc telluride (CZT) gamma camera, was related to renal dysfunction in patients with normal myocardial perfusion imaging (MPI) findings. METHODS: The study population consisted of 46 patients with CKD and 46 individuals without CKD (controls)...
August 30, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28847545/cardiac-123-i-mibg-scintigraphy-is-associated-with-freedom-of-appropriate-icd-therapy-in-stable-chronic-heart-failure-patients
#9
Derk O Verschure, Joris R de Groot, Siroos Mirzaei, Olivier Gheysens, Kenichi Nakajima, Berthe L F van Eck-Smit, G Aernout Somsen, Hein J Verberne
AIM: Chronic heart failure (CHF) is a life-threatening clinical syndrome, partly due to sudden cardiac death (SCD). Implantable cardioverter defibrillators (ICD) for primary prevention of SCD have improved overall survival of CHF patients. However, a high percentage of patients never receives appropriate ICD therapy. This prospective multicentre study evaluated whether cardiac sympathetic activity assessed by (123)I-mIBG scintigraphy could be helpful in selecting patients for ICD implantation...
August 25, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28844804/dat-spect-may-have-diagnostic-value-in-prodromal-sca2-patients-with-parkinsonism
#10
Noriyuki Miyaue, Satoshi Tada, Rina Ando, Hirotaka Iwaki, Hayato Yabe, Noriko Nishikawa, Masahiro Nagai, Hiroshi Takashima, Masahiro Nomoto
INTRODUCTION: Although spinocerebellar ataxia type 2 (SCA2) is classified as hereditary spinocerebellar degeneration, some patients present with parkinsonism before developing cerebellar ataxia. METHODS: (123)I-metaiodobenzyl guanidine ((123)I-MIBG) myocardial scintigraphy and/or dopamine transporter single photon emission computed tomography (DAT SPECT) using (123)I-ioflupane ((123)I-FP-CIT) were performed for the six patients from three SCA2 families. RESULTS: (123)I-MIBG myocardial scintigraphy showed reduced cardiac uptake in four of five patients and an association with Lewy body disease was suggested...
August 14, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28840574/cardioprotection-by-minocycline-in-a-rabbit-model-of-ischemia-reperfusion-injury-detection-of-cell-death-by-in-vivo-111-in-gsao-spect
#11
Takayoshi Yamaki, Hans J de Haas, Nobuhiro Tahara, Artiom Petrov, Dilbahar Mohar, Nezam Haider, Jun Zhou, Atsuko Tahara, Yasuchika Takeishi, Hendrikus H Boersma, Tiziano Scarabelli, Annapoorna Kini, H William Strauss, Jagat Narula
BACKGROUND: Preclinical studies indicate that minocycline protects against myocardial ischemia/reperfusion injury. In these studies, minocycline was administered before ischemia, which can rarely occur in clinical practice. The current study aimed to evaluate cardioprotection by minocycline treatment upon reperfusion. METHODS: Rabbits were subjected to myocardial ischemia/reperfusion injury and received either intravenous minocycline (n = 8) or saline (n = 8) upon reperfusion...
August 24, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28823060/cardiac-death-in-patients-with-left-ventricular-aneurysm-remodeling-and-myocardial-viability-by-gated-99m-tc-mibi-spect-and-gated-18-f-fdg-pet
#12
Weixue Wang, Xiang Li, Congna Tian, Shihua Zhao, Marcus Hacker, Xiaoli Zhang
(1) To evaluate the prognostic value of LV remodeling parameters in patients with LV aneurysm by gated SPECT (GSPECT), gated PET (GPET) and CMR; (2) to evaluate the impact of myocardial viability and LV remodeling on the long-term cardiac survival in patients with LV aneurysm. One hundred and twenty-six consecutive patients underwent GPET, GSPECT and CMR within two weeks, with a mean follow-up of 3.9 ± 1.5 years. End-diastolic volume (EDV, mL) and end-systolic volume (ESV, mL) measured by GPET, GSPECT and CMR and corrected for BSA; EDVI and ESVI were calculated...
August 19, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28817662/single-scan-rest-stress-imaging-with-99mtc-sestamibi-and-cadmium-zinc-telluride-based-spect-for-hyperemic-flow-quantification-a-feasibility-study-evaluated-with-cardiac-magnetic-resonance-imaging
#13
Yu-Hua Dean Fang, Yuan-Chang Liu, Kung-Chu Ho, Feng-Cheng Kuo, Ching-Fang Yang, Tzu-Chen Yen, I-Chang Hsieh
INTRODUCTION: We aimed to evaluate whether the hyperemic myocardial blood flow (MBF) can be estimated using cadmium zinc telluride (CZT)-based single-photon emission computed tomography (SPECT) cameras with a single, rapid rest/stress dynamic scan. Dynamic contrast-enhanced (DCE) cardiac magnetic resonance imaging (MRI) was used as a reference modality for flow measurement. MATERIALS AND METHODS: The proposed protocol included both the rest and stress acquisitions within a 24-min scan...
2017: PloS One
https://www.readbyqxmd.com/read/28808939/comparison-of-left-ventricular-shape-by-gated-spect-imaging-in-diabetic-and-nondiabetic-patients-with-normal-myocardial-perfusion-a-propensity-score-analysis
#14
Carmela Nappi, Valeria Gaudieri, Wanda Acampa, Roberta Assante, Emilia Zampella, Ciro Gabriele Mainolfi, Mario Petretta, Guido Germano, Alberto Cuocolo
BACKGROUND: Diabetes mellitus induces structural and functional cardiac alterations that can result in heart failure. Left ventricular (LV) shape is a dynamic component of cardiac geometry influencing its contractile function. However, few data are available comparing LV shape index in diabetic and nondiabetic patients without overt coronary artery disease after balancing for coronary risk factors. METHODS: We studied 1168 patients with normal myocardial perfusion and normal LV ejection fraction on stress gated single-photon emission computed tomography (SPECT) imaging...
August 14, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28792136/impact-of-follow-up-ischemia-on-myocardial-perfusion-single-photon-emission-computed-tomography-in-patients-with-coronary-artery-disease
#15
Se Hun Kang, Hyo In Choi, Young Hak Kim, Eun Young Lee, Jung Min Ahn, Seungbong Han, Pil Hyung Lee, Jae Hyung Roh, Sung Han Yun, Duk Woo Park, Soo Jin Kang, Seung Whan Lee, Cheol Whan Lee, Dae Hyuk Moon, Seong Wook Park, Seung Jung Park
PURPOSE: Few studies have reported on predicting prognosis using myocardial perfusion single-photon emission computed tomography (SPECT) during coronary artery disease (CAD) treatment. Therefore, we aimed to assess the clinical implications of myocardial perfusion SPECT during follow-up for CAD treatment. MATERIALS AND METHODS: We enrolled 1153 patients who had abnormal results at index SPECT and underwent follow-up SPECT at intervals ≥6 months. Major adverse cardiac events (MACE) were compared in overall and 346 patient pairs after propensity-score (PS) matching...
September 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28776314/a-combined-static-dynamic-single-dose-imaging%C3%A2-protocol-to-compare-quantitative-dynamic-spect-with-static-conventional-spect
#16
Maria Sciammarella, Uttam M Shrestha, Youngho Seo, Grant T Gullberg, Elias H Botvinick
BACKGROUND: SPECT myocardial perfusion imaging (MPI) is a clinical mainstay that is typically performed with static imaging protocols and visually or semi-quantitatively assessed for perfusion defects based upon the relative intensity of myocardial regions. Dynamic cardiac SPECT presents a new imaging technique based on time-varying information of radiotracer distribution, which permits the evaluation of regional myocardial blood flow (MBF) and coronary flow reserve (CFR). In this work, a preliminary feasibility study was conducted in a small patient sample designed to implement a unique combined static-dynamic single-dose one-day visit imaging protocol to compare quantitative dynamic SPECT with static conventional SPECT for improving the diagnosis of coronary artery disease (CAD)...
August 3, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28776313/a-new-era-in-gated-myocardial-perfusion-imaging-feasibility-of-data-driven-cardiac-contraction-gating-with-multiple-pinhole-czt-spect
#17
Doumit Daou, Rémy Sabbah, Carlos Coaguila, Yousef Alattar, Hatem Boulahdour
BACKGROUND: We previously validated the use of a data-driven cardiac respiratory-motion (RM) correction method (REGAT) applicable to CZT SPECT myocardial perfusion imaging (MPI). In this study, we adapted the same process used with REGAT for RM to generate data-driven cardiac contraction triggers and corresponding cardiac contraction-gated SPECT studies (GSPECT-DD). We aimed to study its feasibility and compare its performances to GSPECT studies generated with ECG monitor-based triggers (GSPECT-ECG)...
August 3, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28775200/prognostic-value-of-123-i-betamethyl-p-iodophenyl-pentadecanoic-acid-single-photon-emission-computed-tomography-in-patients-with-non-ischemic-heart-failure-with-preserved-ejection-fraction
#18
Hidenobu Hashimoto, Rine Nakanishi, Sunao Mizumura, Yukiko Hashimoto, Yuriko Okamura, Shunsuke Kiuchi, Junichi Yamazaki, Takanori Ikeda
Myocardial fatty acid metabolism imaging using (123)I-betamethyl-p-iodophenyl-pentadecanoic acid single-photon emission computed tomography (BMIPP-SPECT) is a useful modality for identifying high-risk patients with known ischemic heart disease. However, its utility for patients with non-ischemic heart failure with preserved ejection fraction (NIHFpEF) is not well-known. This study aims to evaluate the prognostic value of BMIPP defect score (BDS) in patients presenting with NIHFpEF. Methods: Of 804 consecutive patients who were admitted to the hospital because of acute HF and underwent BMIPP-SPECT, we identified 133 patients (73±13 years) who had normal coronary artery by invasive coronary angiography and preserved left ventricular ejection fraction (≥50%) by echocardiography...
August 3, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28775077/chronic-rejection-of-cardiac-allografts-is-associated-with-increased-lymphatic-flow-and-cellular-trafficking
#19
Lindsey A Edwards, Anna K Nowocin, Nazila V Jafari, Lucy Meader, Kathryn Brown, Aurélien Sarde, Carolyn Lam, Alex Murray, Wilson Wong
Background -Cardiac transplantation is an excellent treatment for end-stage heart disease. However, rejection of the donor graft, particularly by chronic rejection leading to cardiac allograft vasculopathy, remains a major cause of graft loss. The lymphatic system plays a crucial role in the alloimmune response, facilitating trafficking of antigen presenting cells (APCs) to draining lymph nodes (dLN). The encounter of APCs with T lymphocytes in secondary lymphoid organs is essential for the initiation of alloimmunity...
August 3, 2017: Circulation
https://www.readbyqxmd.com/read/28762094/spect-but-not-pet-remains-as-the-working-horse-of-the-state-of-the-art-nuclear-cardiac-imaging-laboratory-con
#20
Antti Saraste, Juhani Knuuti
No abstract text is available yet for this article.
July 31, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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