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Valve replacement in third world countries

N N Subhash, Adathala Rajeev, Sreedharan Sujesh, C V Muraleedharan
Average age group of heart valve replacement in India and most of the Third World countries is below 30 years. Hence, the valve for such patients need to be designed to have a service life of 50 years or more which corresponds to 2000 million cycles of operation. The purpose of this study was to assess the structural performance of the TTK Chitra tilting disc heart valve model TC2 and thereby address its durability. The TC2 model tilting disc heart valves were assessed to evaluate the risks connected with potential structural failure modes...
August 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
Muhammad Farhan Khan, Muhammad Shahzeb Khan, Faizan Imran Bawany, Mudassir Iqbal Dar, Mehwish Hussain, Saima Farhan, Kaneez Fatima, Khizar Hamid, Mohammad Hussham Arshad, Maira Aziz, Uswah Siddiqi, Nashit Irfan Aziz, Muhammad Bazil Musharraf, Abdul Bari Khan
OBJECTIVE: Although mitral valve replacement is frequently performed in patients of all age groups, there are few studies available which determine the causes of operative mortality in mitral valve replacement especially in our region. Therefore, the objective of this study was to identify factors that are significantly associated with operative mortality in mitral valve replacement. METHODS: From August 2012 to March 2013, 80 consecutive patients undergoing mitral valve replacement in a single tertiary hospital were included...
2016: Global Journal of Health Science
Serkan Cay, Goksel Cagirci, Orhan Maden, Yucel Balbay, Sinan Aydogdu
BACKGROUND: A zoonotic infection caused by Brucella spp., brucellosis, is endemic in some areas of the world, like in our country. One of the most devastating conditions related to this infection is endocarditis, although it is rare. Unfortunately, adequate studies on the characteristics of Brucella endocarditis have not been performed. In addition, there was no consensus on optimal type and duration of medical and interventional therapies. AIM: To answer the following questions: what are the clinical characteristics of Brucella endocarditis, which type of therapy should be performed, and can an alternative antibiotic regimen be applied? METHODS: Patients with the diagnosis of Brucella endocarditis were included in the study during a 6-year period...
March 2009: Kardiologia Polska
Luis M Moura, Kameswari Maganti, Jyothy J Puthumana, F Rocha-Gonçalves, Nalini M Rajamannan
PURPOSE OF REVIEW: This review article will discuss aortic stenosis, the evolving studies defining the cellular mechanisms and the potential for medical therapies for the treatment of this disease. RECENT FINDINGS: Currently, the only therapy for these patients is surgical valve replacement. In the past decade there has been a change in the paradigm towards our understanding of the cellular biology of this disease process. Studies in laboratories across the world have demonstrated that this disease has an active biology and that this biology may be targeted with medical therapies similar to that of vascular atherosclerosis...
November 2007: Current Opinion in Cardiology
A Angelini, C Basso, G Grassi, D Casarotto, G Thiene
Since age is no longer considered an additional risk factor for cardiac surgery, the epidemiology of valve disease in the elderly at present may be estimated from the surgical pathology evaluation of valve specimens which are resected at the time of valve replacement. In the time interval 1991-1993, 500 patients underwent native cardiac valve replacement or repair at our University, with a total of 549 valves available for gross and histological examination. Single valve surgery was performed in 451 patients (300 aortic, 148 mitral, 3 tricuspid), and double valve replacement in 49 (47 mitral-aortic, 1 aorto-tricuspid and 1 mitral-tricuspid)...
August 1994: Aging: Clinical and Experimental Research
S John, V V Bashi, P S Jairaj, S Muralidharan, E Ravikumar, I Sathyamoorthy, C Babuthaman, S Krishnaswamy, G Cherian, I P Sukumar
During a 14 year period, 118 young patients between 9 and 20 years of age underwent mitral valve replacement. In view of the acknowledged advantage of durability and minimal thrombogenicity, we chose the Starr-Edwards valve prosthesis in the large majority of our subjects. Other prostheses have also been used. Hospital mortality has been only 3% in the past 5 years. Frail, severely incapacitated children and adolescents have had an impressive spurt in growth and weight and have returned to normal activities...
August 1983: Journal of Thoracic and Cardiovascular Surgery
M Fofana, M Dadhi Balde, S Toure, O Damby, T Sow, A Conde
The cardiovascular pathology is dominated in Guinea, as in most third-world countries, by valve cardiopathies. These valve diseases are particularly severe and affect children and teen-agers, representing a real public health problem. The severity of these cardiopathies is also obvious because of the severe haemodynamic repercussions and the palliative nature of the medical treatment, since most of these patients are in need of a valve replacement procedure, which currently is only available to some of them...
October 1988: Annales de Cardiologie et D'angéiologie
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