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SPECT MPI

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https://www.readbyqxmd.com/read/28330657/diagnostic-accuracy-of-myocardial-perfusion-imaging-with-czt-technology-systemic-review-and-meta-analysis-of-comparison-with%C3%A2-invasive-coronary-angiography
#1
Francesco Nudi, Ami E Iskandrian, Orazio Schillaci, Mariangela Peruzzi, Giacomo Frati, Giuseppe Biondi-Zoccai
OBJECTIVES: This study sought to summarize the evidence on stress myocardial perfusion imaging (MPI) using cadmium-zinc-telluride (CZT) technology for the diagnosis of obstructive coronary artery disease (CAD). The CZT cameras are newly introduced, and comparative data with the conventional Anger technology (Anger-MPI) are lacking. BACKGROUND: The diagnostic accuracy of Anger-MPI for detection of angiographically significant CAD is well established; however, less evidence is available on the diagnostic accuracy of CZT-MPI...
March 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28290100/triage-of-patients-for-attenuation-corrected-stress-first-tc-99m-spect-mpi-using-a-simplified-clinical-pre-test-scoring-model
#2
Shreyas Gowdar, Waseem Chaudhry, Alan W Ahlberg, Milena J Henzlova, W Lane Duvall
BACKGROUND: Stress-only Tc-99m SPECT MPI saves time and reduces radiation exposure while a normal study has a benign prognosis. However, no guidelines exist as to which patients should undergo stress-first MPI. The purpose of this study was to validate a previously published pre-test prediction scoring model and refine the stress-first triage process further if possible. METHODS: We retrospectively reviewed all patients who underwent an attenuation-corrected Tc-99m SPECT MPI over a 39-month period...
March 13, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28290099/fully-automated-analysis-of-attenuation-corrected-spect-for-the-long-term-prediction-of-acute-myocardial-infarction
#3
Manish Motwani, William D Leslie, Andrew L Goertzen, Yuka Otaki, Guido Germano, Daniel S Berman, Piotr J Slomka
BACKGROUND: Most prior studies assessing the prognostic value of SPECT myocardial perfusion imaging (MPI) have used semi-quantitative visual analysis. We assessed the feasibility of large-scale fully automated quantitative analysis of SPECT MPI to predict acute myocardial infarction (AMI). Additionally, we examined the impact of attenuation correction (AC) in automated strategies. METHODS AND RESULTS: 5960 patients underwent rest/stress SPECT MPI with AC. Left ventricular (LV) segmentation, contour QC check, and quantitation of stress and ischemic total perfusion deficit (sTPD, iTPD) were performed...
March 13, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28281088/prognostic-impact-of-myocardial-perfusion-single-photon-emission-computed-tomography-in-patients-with-major-extracardiac-findings-by-computed-tomography-for-attenuation-correction
#4
Charline Zadro, Noé Roussel, Emmanuelle Cassol, Pierre Pascal, Antoine Petermann, Olivier Meyrignac, Marion Jaffro, Pauline Fournier, Maxime Cournot, Michel Galinier, Didier Carrié, Hervé Rousseau, Isabelle Berry, Olivier Lairez
BACKGROUND: Attenuation correction computed tomography (CT) contributes to an improvement in the diagnostic accuracy of myocardial perfusion imaging (MPI) by single photon emission tomography (SPECT). The aim of this study was to explore the prognosis of patients with major findings by CT according to the results of MPI. METHODS AND RESULTS: 1506 patients who underwent MPI by SPECT were retrospectively included. Attenuation correction CT images were systematically analyzed for major and minor abnormalities...
March 9, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28276752/new-solid-state-cadmium-zinc-telluride-technology-for-cardiac-single-photon-emission-computed-tomographic-myocardial-perfusion-imaging
#5
REVIEW
Ali B Alenazy, R Glenn Wells, Terrence D Ruddy
Single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is well established as diagnostic test for patients with suspected or known coronary artery disease. New camera systems have been developed with cadmium-zinc-telluride (CZT) detectors, novel collimator designs and reconstruction software. Areas covered: We review the current state of cardiac SPECT, advances in conventional camera technology and the development and clinical validation of solid-state CZT cameras. Expert commentary: The development of CZT systems is timely and addresses current issues for clinical SPECT imaging...
March 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28224449/the-exerrt-trial-exercise-to-regadenoson-in-recovery-trial-a-phase-3b-open-label-parallel-group-randomized-multicenter-study-to-assess-regadenoson-administration-following-an-inadequate-exercise-stress-test-as-compared-to-regadenoson-without-exercise-for-myocardial
#6
Gregory S Thomas, S James Cullom, Therese M Kitt, Kathleen M Feaheny, Karthikeyan Ananthasubramaniam, Robert J Gropler, Diwakar Jain, Randall C Thompson
BACKGROUND: This study assessed the non-inferiority and safety of regadenoson administration during recovery from inadequate exercise compared with administration without exercise. METHODS: Patients unable to achieve adequate exercise stress were randomized to regadenoson 0.4 mg either during recovery (Ex-Reg) or 1 hour after inadequate exercise (Regadenoson) (MPI1). All patients also underwent non-exercise regadenoson MPI 1-14 days later (MPI2). The number of segments with reversible perfusion defects (RPDs) detected using single photon emission computerized tomography imaging was categorized...
February 21, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28194728/diagnostic-performance-of-the-quantification-of-myocardium-at-risk-from-mpi-spect-cta-2g-fusion-for-detecting-obstructive-coronary-disease-a-multicenter-trial
#7
Marina Piccinelli, Cesar Santana, Gopi Kiran R Sirineni, Russell D Folks, C David Cooke, Chesnal D Arepalli, Santiago Aguade-Bruix, Zohar Keidar, Alex Frenkel, Ora Israel, Jaume Candell-Riera, Ernest V Garcia
BACKGROUND: The effective non-invasive identification of coronary artery disease (CAD) and its proper referral for invasive treatment are still unresolved issues. We evaluated our quantification of myocardium at risk (MAR) from our second generation 3D MPI/CTA fusion framework for the detection and localization of obstructive coronary disease. METHODS: Studies from 48 patients who had rest/stress MPI, CTA, and ICA were analyzed from 3 different institutions. From the CTA, a 3D biventricular surface of the myocardium with superimposed coronaries was extracted and fused to the perfusion distribution...
February 13, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28181156/the-significance-of-post-stress-decrease-in-left-ventricular-ejection-fraction-in-patients-undergoing-regadenoson-stress-gated-spect-myocardial-perfusion-imaging
#8
Javier Gomez, Yasmeen Golzar, Ibtihaj Fughhi, Adebayo Olusanya, Rami Doukky
BACKGROUND: The significance of post-stress decrease in left ventricular ejection fraction (LVEF) with regadenoson stress gated SPECT (GSPECT) myocardial perfusion imaging (MPI) has not been studied. METHODS AND RESULTS: Consecutive patients who underwent rest/regadenoson stress GSPECT-MPI followed by coronary angiography within 6 months were analyzed. Change in LVEF by GSPECT-MPI was calculated as stress LVEF minus rest LVEF; a significant decrease was tested at 5% and 10% thresholds...
February 8, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28160264/impact-of-data-driven-cardiac-respiratory-motion-correction-on-the-extent-and-severity-of-myocardial-perfusion-defects-with-free-breathing-czt-spect
#9
Doumit Daou, Rémy Sabbah, Carlos Coaguila, Hatem Boulahdour
BACKGROUND: We previously reported the clinical feasibility and positive impact on image characteristics of a data-driven cardiac respiratory motion (RM) correction method (REGAT) applicable to CZT SPECT myocardial perfusion imaging (MPI). Here, we evaluate its impact on the extent and severity of myocardial perfusion defects (MPD). METHODS: We included 25 patients having a 1-day (99m)Tc-Tetrofosmin stress/rest MPI acquired with multi-pinhole CZT SPECT. Acquisitions were processed with REGAT to generate mean RM gated SPECT...
February 3, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28155191/left-ventricular-functional-parameters-by-gated-spect-myocardial-perfusion-imaging-in-a-latin-american-country
#10
Miguel Kapitan, Alvaro Beltran, Mario Beretta, Fernando Mut
BACKGROUND: There is paucity of data on left ventricular (LV) functional parameters using gated SPECT myocardial perfusion imaging (MPI) from the Latin American region. This study provides detailed information in low-risk patients both at rest and during exercise. METHODS AND RESULTS: We studied 90 patients (50 men) with a very low likelihood of coronary artery disease. Gated-SPECT MPI was performed with Tc-99m MIBI using a 2-day protocol, with 16 frames/R-R cycle...
February 2, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28144811/influence-of-acquisition-orbit-on-phase-analysis-of-gated-single-photon-emission-computed-tomography-myocardial-perfusion-imaging-for-assessment-of-left-ventricular-mechanical-dyssynchrony
#11
Tomofumi Misaka, Makoto Hosono, Takashi Kudo, Takamichi Ito, Tsutomu Syomura, Masanobu Uemura, Kaoru Okajima
OBJECTIVE: The association between left ventricular (LV) dyssynchrony parameters, given by phase analysis of gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI), and acquisition orbits is unclear. The aim of this study was to assess the dependence of LV dyssynchrony parameters on acquisition orbits. METHODS: Ninety-nine patients who underwent (201)Tl-gated SPECT MPI were categorized into minor hypoperfusion or major hypoperfusion groups...
January 31, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28138354/normal-databases-for-the-relative-quantification-of-myocardial-perfusion
#12
Mathieu Rubeaux, Yuan Xu, Guido Germano, Daniel S Berman, Piotr J Slomka
PURPOSE OF REVIEW: Myocardial perfusion imaging (MPI) with SPECT is performed clinically worldwide to detect and monitor coronary artery disease (CAD). MPI allows an objective quantification of myocardial perfusion at stress and rest. This established technique relies on normal databases to compare patient scans against reference normal limits. In this review, we aim to introduce the process of MPI quantification with normal databases and describe the associated perfusion quantitative measures that are used...
August 2016: Current Cardiovascular Imaging Reports
https://www.readbyqxmd.com/read/28077904/regadenoson-in-myocardial-perfusion-study-first-institutional-experiences-in-bosnia-and-herzegovina
#13
Nermina Beslic, Renata Milardovic, Amera Sadija, Sejla Ceric, Zeljka Raic
INTRODUCTION: Myocardial perfusion imaging (MPI) is widely used in the evaluation of known and suspected coronary artery disease (CAD). Imaging of heart in stress and rest enables the comparison of myocardial uptake of radiotracer in proportion to the needs and coronary flow, which is used for detection of perfusion defects. Exercise stress and pharmacologic agents are used for the stressing purpose. Novel pharmacologic stressor regadenoson is A2A selective adenosine agonist, which selectively binds to the adenosine receptors in coronary arteries causing coronary dilatation...
December 2016: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28050863/incremental-prognostic-value-of-spect-mpi-in-chronic-kidney-disease-a-reclassification-analysis
#14
Amjad M Ahmed, Waqas T Qureshi, Wesley T O'Neal, Fatima Khalid, Mouaz H Al-Mallah
BACKGROUND: Traditional cardiovascular (CV) risk factors have limited predictive value of CV mortality in patients with chronic kidney disease (CKD, creatinine clearance less than 60 mL/minute per 1.73 m(2)). The aim of this study was to evaluate incremental and independent prognostic value of single-photon emission computerized tomography-myocardial perfusion imaging (SPECT-MPI) across continuum of renal function. METHODS: We retrospectively studied 11,518 (mean age, 65 ± 12 years; 52% were men) patients referred for a clinical indication of SPECT-MPI between April 2004 and May 2009...
January 3, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28032913/correction-of-hysteretic-respiratory-motion-in-spect-myocardial-perfusion-imaging-simulation-and-patient-studies
#15
Paul K R Dasari, Arda Könik, P Hendrik Pretorius, Karen L Johnson, William P Segars, Mohammed S Shazeeb, Michael A King
PURPOSE: Amplitude-based respiratory gating is known to capture the extent of respiratory motion (RM) accurately but results in residual motion in the presence of respiratory hysteresis. In our previous study, we proposed and developed a novel approach to account for respiratory hysteresis by applying the Bouc-Wen (BW) model of hysteresis to external surrogate signals of anterior/posterior motion of the abdomen and chest with respiration. In this work, using simulated and clinical SPECT myocardial perfusion imaging (MPI) studies, we investigate the effects of respiratory hysteresis and evaluate the benefit of correcting it using the proposed BW model in comparison with the abdomen signal typically employed clinically...
February 2017: Medical Physics
https://www.readbyqxmd.com/read/28025263/quantitative-plaque-features-from-coronary-computed-tomography-angiography-to-identify-regional-ischemia-by-myocardial-perfusion-imaging
#16
Mariana Diaz-Zamudio, Tobias A Fuchs, Piotr Slomka, Yuka Otaki, Reza Arsanjani, Heidi Gransar, Guido Germano, Daniel S Berman, Philipp A Kaufmann, Damini Dey
AIMS: We aimed to investigate whether quantitative plaque features measured from coronary CT angiography (CCTA) predict ischemia by myocardial perfusion SPECT imaging (MPI). METHODS AND RESULTS: Hundred and eighty-four consecutive patients (63% males) with suspected-coronary artery disease, undergoing hybrid CCTA, and attenuation corrected solid state (99m)Tc stress/rest MPI and single vessel ischemia were considered. Quantitative analysis of CCTA derived non-calcified plaque (NCP), low-density NCP [< 30 Hounsfield Units (HU)] (LDNCP), calcified and total plaque burdens (%, normalized to vessel volume), maximum diameter stenosis and contrast density difference (CD, maximum difference in HU/lumen area within lesion)...
December 26, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28012120/improvement-in-automated-quantitation-of-myocardial-perfusion-abnormality-by-using-iterative-reconstruction-image-in-combination-with-resolution-recovery-attenuation-and-scatter-corrections-for-the-detection-of-coronary-artery-disease
#17
Taiki Chono, Masahisa Onoguchi, Takayuki Shibutani, Akiyoshi Hashimoto, Tomoaki Nakata, Naoya Yama, Kazufumi Tsuchihashi, Masamitsu Hatakenaka
OBJECTIVE: An iterative reconstruction method in combination with resolution recovery, attenuation and scatter corrections (IR-RASC) can improve image quality. It, however, is undetermined whether this technique can improve the detection of coronary artery disease (CAD) when automated quantitative analysis is used. This study evaluated diagnostic values of IR-RASC in combination with automated quantitative analysis in stress myocardial perfusion imaging (MPI) in the CAD detection. METHODS: This study enrolled consecutive 64 patients (mean age 66...
February 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27987028/left-ventricular-function-in-response-to-dipyridamole-stress-head-to-head-comparison-between-82-rubidium-pet-and-99m-tc-sestamibi-spect-ecg-gated-myocardial-perfusion-imaging
#18
Maria Clementina Giorgi, Jose Claudio Meneghetti, Jose Soares, Marisa Izaki, Andréa Falcão, Rodrigo Imada, William Chalela, Marco Antonio de Oliveira, Cesar Nomura, Hein J Verberne
PURPOSE: Myocardial perfusion imaging (MPI) with (99m)Tc-sestamibi (sestamibi) SPECT and rubidium-82 ((82)Rb) PET both allow for combined assessment of perfusion and left ventricular (LV) function. We sought to compare parameters of LV function obtained with both methods using a single dipyridamole stress dose. MATERIALS AND METHODS: A group of 221 consecutive patients (65.2 ± 10.4 years, 52.9% male) underwent consecutive sestamibi and (82)Rb MPI after a single dipyridamole stress dose...
December 16, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27900642/ischemia-burden-on-stress-spect-mpi-predicts-long-term-outcomes-after-revascularization-in-stable-coronary-artery-disease
#19
Hendrik J Boiten, Jan C van den Berge, Roelf Valkema, Ron T van Domburg, Felix Zijlstra, Arend F L Schinkel
BACKGROUND: It is not entirely clear whether ischemia burden on stress single-photon emission computed tomography (SPECT) effectively identifies patients who have a long-term benefit from coronary revascularization. METHODS: The study population consisted of 719 patients with ischemia on stress SPECT. Early coronary revascularization was defined as percutaneous coronary intervention or coronary artery bypass grafting ≤90 days after SPECT. Patients who underwent late revascularization (>90 days after SPECT) were excluded (n = 164)...
November 29, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27858346/single-ct-for-attenuation-correction-of-rest-stress-cardiac-spect-perfusion-imaging
#20
R Glenn Wells, Mikael Trottier, Manuja Premaratne, Karen Vanderwerf, Terrence D Ruddy
Common practice is to use separate CT scans acquired during rest and stress for attenuation correction of SPECT myocardial perfusion imaging (MPI). We evaluated using a single CT scan to correct both rest and stress SPECT scans. Studies from 154 patients were reprocessed using one CT acquired at stress to correct both rest and stress scans (1CT) and compared to correction of each scan with its own CT (2CT). Two expert readers independently read the images and determined summed stress (SSS), rest (SRS), and difference (SDS) scores...
November 17, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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