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SPECT MPI

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https://www.readbyqxmd.com/read/29657046/impact-of-cardiac-hybrid-imaging-guided-patient-management-on-clinical-long-term-outcome
#1
Dominik C Benz, Lara Gaemperli, Christoph Gräni, Elia von Felten, Andreas A Giannopoulos, Michael Messerli, Ronny R Buechel, Oliver Gaemperli, Aju P Pazhenkottil, Philipp A Kaufmann
BACKGROUND: Although randomized trials have provided evidence for invasive fractional flow reserve to guide revascularization, evidence for non-invasive imaging is less well established. The present study investigated whether hybrid coronary computed tomography (CCTA)/single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) can identify patients who benefit from early revascularization compared to medical therapy. METHODS: This retrospective study consists of 414 patients referred for evaluation of known or suspected coronary artery disease (CAD) with CCTA/SPECT hybrid imaging...
June 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29550305/deep-learning-for-prediction-of-obstructive-disease-from-fast-myocardial-perfusion-spect-a-multicenter-study
#2
Julian Betancur, Frederic Commandeur, Mahsaw Motlagh, Tali Sharir, Andrew J Einstein, Sabahat Bokhari, Mathews B Fish, Terrence D Ruddy, Philipp Kaufmann, Albert J Sinusas, Edward J Miller, Timothy M Bateman, Sharmila Dorbala, Marcelo Di Carli, Guido Germano, Yuka Otaki, Balaji K Tamarappoo, Damini Dey, Daniel S Berman, Piotr J Slomka
OBJECTIVES: The study evaluated the automatic prediction of obstructive disease from myocardial perfusion imaging (MPI) by deep learning as compared with total perfusion deficit (TPD). BACKGROUND: Deep convolutional neural networks trained with a large multicenter population may provide improved prediction of per-patient and per-vessel coronary artery disease from single-photon emission computed tomography MPI. METHODS: A total of 1,638 patients (67% men) without known coronary artery disease, undergoing stress 99m Tc-sestamibi or tetrofosmin MPI with new generation solid-state scanners in 9 different sites, with invasive coronary angiography performed within 6 months of MPI, were studied...
March 12, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29520004/mechanical-dyssynchrony-and-diastolic-dysfunction-are-common-in-lvh-a-pilot-correlation-study-using-doppler-echocardiography-and-czt-gated-spect-mpi
#3
Szu-Ying Tsai, Shan-Ying Wang, Yu-Chien Shiau, Yen-Wen Wu
Hypertrophic cardiomyopathy (HCM) is an often under-diagnosed cause of left ventricular hypertrophy (LVH). It affects 1/500 of the population, is the most commonly inherited cardiovascular disorder, and can present in apical, concentric, or septal forms. Although most patients are asymptomatic, sudden cardiac death can be the initial presentation of HCM. By retrospectively enrolling patients suspected of having three different types of HCM in the absence of epicardial coronary stenosis, we aimed to examine systolic and diastolic dysfunction and perfusion abnormalities using both Doppler echocardiography and state-of-the-art gated single-photon emission computerized tomography (SPECT) myocardial perfusion imaging (MPI) with a cadmium-zinc-telluride camera and thallium-201...
March 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29502312/prognostic-value-of-normal-stress-myocardial-perfusion-imaging-and-ventricular-function-in-japanese-patients-with-chronic-kidney-disease-a-study-based-on-the-j-access-3-database
#4
Shinro Matsuo, Kenichi Nakajima, Yasuchika Takeishi, Tsunehiko Nishimura
BACKGROUND: The purpose of this study is to test the hypothesis that a normal myocardial perfusion imaging (MPI) study in chronic kidney disease (CKD) can provide benign prognostic information for the prediction of major cardiovascular events. METHODS: The study group consisted of 431 CKD patients (males, 64%; mean age, 72 ± 11 years) with normal SPECT imaging. Based on SPECT image and QGS data, 331 had a summed stress score of 3 or less, a summed difference score of 1 or less and normal cardiac function (males; end-systolic volume (ESV) ≤ 60 ml, females; ESV ≤ 40 ml, males, ejection fraction (EF) ≥ 49%; females, EF ≥ 50%)...
March 3, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29470616/automated-spect-analysis-compared-with-expert-visual-scoring-for-the-detection-of-ffr-defined-coronary-artery-disease
#5
R S Driessen, P G Raijmakers, I Danad, W J Stuijfzand, S P Schumacher, J A Leipsic, J K Min, J Knuuti, A A Lammertsma, A C van Rossum, N van Royen, S R Underwood, P Knaapen
PURPOSE: Traditionally, interpretation of myocardial perfusion imaging (MPI) is based on visual assessment. Computer-based automated analysis might be a simple alternative obviating the need for extensive reading experience. Therefore, the aim of the present study was to compare the diagnostic performance of automated analysis with that of expert visual reading for the detection of obstructive coronary artery disease (CAD). METHODS: 206 Patients (64% men, age 58...
February 22, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29430109/comparison-of-left-ventricular-phase-parameters-analysis-between-two-software-programs-in-patients-with-normal-gated-single-photon-emission-computed-tomography-myocardial-perfusion-imaging
#6
Dharmender Malik, Ashwani Sood, Madan Parmar, Bhagwant Rai Mittal
Background: Phase analysis can be easily performed by different software to assess the left ventricular dyssynchrony from gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) with high precision. However, the normal values of histogram bandwidth (HBW) and phase standard deviation (PSD) and their comparison using different programs have not been fully elucidated and actively being evaluated at present. The aim of this study was to determine the phase analysis parameters values and to compare the phase indices of two commonly used programs in a group of patients with normal gated SPECT-MPI...
January 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29417419/summed-thickening-score-by-myocardial-perfusion-imaging-a-risk-factor-of-left-ventricular-remodeling-in-patients-with-myocardial-infarction
#7
Wei Yang, Feifei Zhang, Haipeng Tang, Xiaoliang Shao, Jianfeng Wang, Xiaosong Wang, Xiaonan Shao, Wenchong Xin, Ling Yang, Weihua Zhou, Yuetao Wang
BACKGROUND: Left ventricular (LV) remodeling has adverse effects on the prognosis of patients with myocardial infarction (MI). The aim of this study is to identify the risk factors of LV remodeling in MI patients by radionuclide myocardial imaging. METHODS AND RESULTS: This retrospective study consisted of 92 patients who had a history of definite prior MI on ECG and underwent both resting gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) and positron emission tomography (PET) myocardial metabolism imaging...
February 7, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29404896/refining-risk-in-diabetes-and-cad-with-spect-mpi-new-insights-and-future-challenges
#8
EDITORIAL
Syed Y Naqvi, Steven D Wittlin, Ronald G Schwartz
No abstract text is available yet for this article.
February 5, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29392627/left-ventricular-mechanical-dyssynchrony-assessment-in-long-standing-type-ii-diabetes-mellitus-patients-with-normal-gated-spect-mpi
#9
Dharmender Malik, Bhagwant Mittal, Ashwani Sood, Madan Parmar, Gurvinder Kaur, Ajay Bahl
BACKGROUND: Assessment of left ventricular mechanical dyssynchrony (LVMD) using phase analysis of gated SPECT-MPI is well established. However, there is little information about the influence of diabetes mellitus on phase analysis. The present work was to evaluate the LVMD in longstanding type II diabetes mellitus (DM) patients with normal gated SPECT-MPI. METHODS: Retrospective analysis of 146 (86 type II diabetics for > 5 years' duration and 60 nondiabetics) consecutive patients with normal gated SPECT-MPI and adequate LVEF was done...
February 1, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29390486/diagnostic-value-of-thallium-201-myocardial-perfusion-iq-spect-without-and-with-computed-tomography-based-attenuation-correction-to-predict-clinically-significant-and-insignificant-fractional-flow-reserve-a-single-center-prospective-study
#10
Haruki Tanaka, Teruyuki Takahashi, Norihiko Ohashi, Koichi Tanaka, Takenori Okada, Yasuki Kihara
The aim of this study was to clarify the predictive value of fractional flow reserve (FFR) determined by myocardial perfusion imaging (MPI) using thallium (Tl)-201 IQ-SPECT without and with computed tomography-based attenuation correction (CT-AC) for patients with stable coronary artery disease (CAD).We assessed 212 angiographically identified diseased vessels using adenosine-stress Tl-201 MPI-IQ-SPECT/CT in 84 consecutive, prospectively identified patients with stable CAD. We compared the FFR in 136 of the 212 diseased vessels using visual semiquantitative interpretations of corresponding territories on MPI-IQ-SPECT images without and with CT-AC...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29340989/gated-spect-myocardial-perfusion-imaging-with-cadmium-zinc-telluride-detectors-allows-real-time-assessment-of-dobutamine-stress-induced-wall-motion-abnormalities
#11
Rene Nkoulou, Mathias Wolfrum, Aju P Pazhenkottil, Michael Fiechter, Ronny R Buechel, Oliver Gaemperli, Philipp A Kaufmann
BACKGROUND: Left ventricular (LV) ejection fraction (EF) during high dobutamine stress (HD) by real-time gated-SPECT myocardial perfusion imaging (MPI) on a cadmium-zinc-telluride (CZT) gamma camera was validated versus cardiac magnetic resonance imaging (CMR). METHODS AND RESULTS: After injecting 99mTc-tetrofosmin (320 MBq) in 50 patients (mean age 64 +/- 11 years), EF at rest and post-stress as well as relevant changes in EF at HD (ΔEF ≥ 5%) were assessed. CZT and CMR rest EF values yielded an excellent correlation and agreement (r = 0...
January 16, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29319132/evaluation-of-changes-in-perfusion-defect-and-left-ventricular-systolic-function-using-tc-99m-tetrofosmin-single-photon-emission-computed-tomography-over-3-month-period-in-patients-of-acute-myocardial-infarction-undergoing-primary-angioplasty
#12
Anil Kumar Avs, P G Kumar, Ajay Swami, Yiteedra Dinker
BACKGROUND: After a primary transluminal coronary angioplasty (PTCA) following AMI (acute myocardial infarction), the perfusion defect and LV (left ventricular) function recover/change over a period of time. The analysis immediately after the procedure may not be true depiction of the exact success of the procedure. There is varying and scanty information available on the natural course of changes in these parameters after a successful PTCA. We hypothesized that majority of change occurs at 3-4 month period...
January 10, 2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29315366/long-term-prognostic-value-of-single-photon-emission-computed-tomography-myocardial-perfusion-imaging-after-primary-pci-for-stemi
#13
Jeff M Smit, Maaike P Hermans, Aukelien C Dimitriu-Leen, Alexander R van Rosendael, Petra Dibbets-Schneider, Lioe-Fee de Geus-Oei, Bart J Mertens, Martin J Schalij, Jeroen J Bax, Arthur J Scholte
Aims: The aim of this study was to determine the long-term prognostic value of infarct size and myocardial ischaemia on single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI) after primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). Methods and results: In total, 1092 STEMI patients who underwent primary PCI and SPECT MPI within 1-6 months were included (median follow-up time of 6...
January 5, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29243071/assessment-of-left-ventricular-mass-by-spect-mpi
#14
EDITORIAL
René R Sevag Packard, Jamshid Maddahi
No abstract text is available yet for this article.
December 14, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29214612/complete-revascularization-determined-by-myocardial-perfusion-imaging-could-improve-the-outcomes-of-patients-with-stable-coronary-artery-disease-compared-with-incomplete-revascularization-and-no-revascularization
#15
Jiehui Li, Xiubin Yang, Yueqin Tian, Hongxing Wei, Marcus Hacker, Xiang Li, Xiaoli Zhang
OBJECTIVES: To compare the outcomes among patients treated by complete coronary revascularization (CCR) or incomplete coronary revascularization (ICR) and no coronary revascularization (NCR) by myocardial perfusion imaging (MPI), as well as to evaluate the impact of severity of ischemia on patients with coronary artery disease (CAD) by different therapy strategies. BACKGROUND: Using myocardial ischemia severity determined by MPI guiding treatment strategies for CAD patients still lacks strong clinical evidences...
December 6, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29214611/coronary-risk-equivalence-of-diabetes-assessed-by-spect-mpi
#16
Donna Chelle V Morales, Sanjeev P Bhavnani, Alan W Ahlberg, Raja C Pullatt, Deborah M Katten, Donna M Polk, Gary V Heller
BACKGROUND: Several publications and guidelines designate diabetes mellitus (DM) as a coronary artery disease (CAD) risk equivalent. The aim of this investigation was to examine DM cardiac risk equivalence from the perspective of stress SPECT myocardial perfusion imaging (MPI). METHODS AND RESULTS: We examined cardiovascular outcomes (cardiac death or nonfatal MI) of 17,499 patients referred for stress SPECT-MPI. Patients were stratified into four categories: non-DM without CAD, non-DM with CAD, DM without CAD, and DM with CAD, and normal or abnormal perfusion...
December 6, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29209950/spect-myocardial-ischemia-in-the-absence-of-obstructive-cad-contribution-of-the-invasive-assessment-of-microvascular-dysfunction
#17
Loïc Djaïleb, Laurent Riou, Nicolas Piliero, Adrien Carabelli, Estelle Vautrin, Alexis Broisat, Julien Leenhardt, Jacques Machecourt, Daniel Fagret, Gerald Vanzetto, Gilles Barone-Rochette, Catherine Ghezzi
Coronary microvascular dysfunction has recently emerged as a major independent prognostic factor and can be invasively assessed by coronary flow reserve (CFR) and the index of microvascular resistance (IMR). The incremental prognostic value of myocardial ischemia from SPECT myocardial perfusion imaging (MPI) over clinical characteristics, cardiac risk factors, and stress test data for the prediction of hard cardiac events (myocardial infarction and cardiac death) has been well demonstrated over the last two decades regardless of the absence or presence of epicardial CAD...
December 5, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29197024/impact-of-incomplete-ventricular-coverage-on-diagnostic-performance-of-myocardial-perfusion-imaging
#18
Behzad Sharif, Manish Motwani, Reza Arsanjani, Rohan Dharmakumar, Mathews B Fish, Guido Germano, Debiao Li, Daniel S Berman, Piotr Slomka
In the context of myocardial perfusion imaging (MPI) with cardiac magnetic resonance (CMR), there is ongoing debate on the merits of using technically complex acquisition methods to achieve whole-heart spatial coverage, rather than conventional 3-slice acquisition. An adequately powered comparative study is difficult to achieve given the requirement for two separate stress CMR studies in each patient. The aim of this work is to draw relevant conclusions from SPECT MPI by comparing whole-heart versus simulated 3-slice coverage in a large existing dataset...
December 1, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29196789/prediction-of-functional-recovery-after-primary-pci-using-the-estimate-of-myocardial-salvage-in-gated-spect-early-after-acute-myocardial-infarction
#19
Raffaella Calabretta, Angelo Castello, Flavia Linguanti, Francesca Tutino, Alfonso Ciaccio, Cristina Giglioli, Roberto Sciagrà
PURPOSE: Primary percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) aims to achieve myocardial salvage (MS). Because the reference method for measuring MS requires myocardial perfusion imaging (MPI) after tracer injection before PCI, alternative approaches have been proposed, but none has gained wide acceptance. Gated SPECT MPI can assess infarct size (IS), but can also show myocardial stunning. Thus, we compared functional and perfusion abnormalities early after AMI to estimate MS, and to predict left ventricular ejection fraction (LVEF) recovery at follow-up...
April 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29186661/sulfonyl-containing-boronate-caps-for-optimization-of-biological-properties-of-99m-tc-iii-radiotracers-99m-tccl-cdo-cdoh-2-b-r-cdoh-2-cyclohexanedione-dioxime
#20
Zuo-Quan Zhao, Min Liu, Wei Fang, Shuang Liu
In this study, different boronate caps were used to optimize biodistribution properties of radiotracers [99m TcCl(CDO)(CDOH)2 B-R] (1, R = 3S; 2, R = 3SP; 3, R = 3MS; 4, R = 3DMS; 5, R = 3MSB; 6, R = 3MMS; 7, R = 3MSA; 8, R = 3DMSA; 9, R = 4S; 10, R = 4MS; 11, R = 4MSB). Among the 11 new99m Tc radiotracers, 2 shows the most promising characteristics of an optimal heart imaging agent. Its initial heart uptake is close to that of99m Tc-Teboroxime, but its heart retention time is significantly longer. Its heart/liver, heart/lung, and heart/muscle ratios are also better than those of99m Tc-Teboroxime...
January 11, 2018: Journal of Medicinal Chemistry
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