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SPECT MPI

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https://www.readbyqxmd.com/read/27900642/ischemia-burden-on-stress-spect-mpi-predicts-long-term-outcomes-after-revascularization-in-stable-coronary-artery-disease
#1
Hendrik J Boiten, Jan C van den Berge, Roelf Valkema, Ron T van Domburg, Felix Zijlstra, Arend F L Schinkel
BACKGROUND: It is not entirely clear whether ischemia burden on stress single-photon emission computed tomography (SPECT) effectively identifies patients who have a long-term benefit from coronary revascularization. METHODS: The study population consisted of 719 patients with ischemia on stress SPECT. Early coronary revascularization was defined as percutaneous coronary intervention or coronary artery bypass grafting ≤90 days after SPECT. Patients who underwent late revascularization (>90 days after SPECT) were excluded (n = 164)...
November 29, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27858346/single-ct-for-attenuation-correction-of-rest-stress-cardiac-spect-perfusion-imaging
#2
R Glenn Wells, Mikael Trottier, Manuja Premaratne, Karen Vanderwerf, Terrence D Ruddy
Common practice is to use separate CT scans acquired during rest and stress for attenuation correction of SPECT myocardial perfusion imaging (MPI). We evaluated using a single CT scan to correct both rest and stress SPECT scans. Studies from 154 patients were reprocessed using one CT acquired at stress to correct both rest and stress scans (1CT) and compared to correction of each scan with its own CT (2CT). Two expert readers independently read the images and determined summed stress (SSS), rest (SRS), and difference (SDS) scores...
November 17, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27858344/association-between-non-perfusion-parameters-and-presence-of-ischemia-in-gated-spect-myocardial-perfusion-imaging-studies
#3
Amalia Peix, Lázaro O Cabrera, Kenia Padrón, Lydia Rodríguez, Jesús Fernández, Giselle López, Regla Carrillo, Erick Mena, Yoel Fernández, Maurizio Dondi, Diana Páez
BACKGROUND: Combined assessment of perfusion and function improves diagnostic and prognostic power of gated-SPECT in patients with coronary artery disease. The aim of this study was to investigate whether the presence of stress-induced ischemia is associated with abnormal resting left ventricular (LV) function and intraventricular dyssynchrony. METHODS AND RESULTS: Gated-SPECT myocardial perfusion imaging (MPI) at rest and 15 min post-stress was performed in 101 patients, who were divided into three groups: those with stress-induced ischemia (Group 1, n = 58), those with normal scans (Group 2, n = 28), and those with scar but no ischemia (Group 3, n = 15)...
November 17, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27834038/artifacts-in-quantitative-analysis-of-myocardial-perfusion-spect-using-cedars-sinai-qps-software
#4
Hadi Malek, Nahid Yaghoobi, Raheleh Hedayati
Quantitative analysis of myocardial perfusion Single photon emission computerized tomography (SPECT) images is increasingly applied in modern nuclear cardiology practice, assisting in the interpretation of myocardial perfusion images (MPI). There are different extensively validated state-of-the-art software packages, including QPS (cedars-Sinai), Corridor 4DM (University of Michigan) and Emory cardiac toolbox (Emory university), providing highly accurate and reproducible data. However, these software packages may suffer from potential artifacts related to patient or technical factors...
November 10, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27811121/automatic-valve-plane-localization-in-myocardial-perfusion-spect-ct-by-machine-learning-anatomical-and-clinical-validation
#5
Julian Betancur, Mathieu Rubeaux, Tobias Fuchs, Yuka Otaki, Yoav Arnson, Leandro Slipczuk, Dominik Benz, Guido Germano, Damini Dey, Chih-Jen Lin, Daniel Berman, Philipp Kaufmann, Piotr Slomka
: Precise definition of the mitral valve plane (VP) during segmentation of the left ventricle (LV) for single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) quantification often requires manual adjustment, which affects quantification of perfusion. We developed a machine learning approach using support vector machines (SVM) for automatic VP placement. METHODS: 392 consecutive patients undergoing fast SPECT MPI (99m)Tc-tetrofosmin stress (5 min, 300-350 MBq)/rest (5 min, 750-1050 MBq) attenuation corrected (AC) by computed tomography (CT) and same‑day coronary CT angiography (CCTA), including 48 patients with invasive angiography (ICA) and no known coronary artery disease, were studied...
November 3, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27796852/functional-compared-to-anatomical-imaging-in-the-initial-evaluation-of-patients-with-suspected-coronary-artery-disease-an-international-multi-center-randomized-controlled-trial-iaea-spect-cta-study
#6
Ganesan Karthikeyan, Barbara Guzic Salobir, Borut Jug, Niveditha Devasenapathy, Erick Alexanderson, Joao Vitola, Otakar Kraft, Elgin Ozkan, Saket Sharma, Gaurav Purohit, Maja Dolenc Novak, Aloha Meave, Sergio Trevethan, Rodrigo Cerci, Sandra Zier, Lucia Gotthardtová, Tomáš Jonszta, Timucin Altin, Cigdem Soydal, Chetan Patel, Gurpreet Gulati, Diana Paez, Maurizio Dondi, Ravi Kashyap
OBJECTIVE: To test the hypothesis that, in the initial evaluation of patients with suspected coronary artery disease (CAD), stress myocardial perfusion imaging (MPI) would result in less downstream testing than coronary computed tomographic angiography (CCTA). METHODS: In this international, randomized trial, mildly symptomatic patients with an intermediate likelihood of having CAD, and asymptomatic patients at intermediate risk of cardiac events, underwent either initial stress-rest MPI or CCTA...
October 28, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27796850/cardiovascular-risk-stratification-after-renal-transplant-is-spect-mpi-the-answer
#7
EDITORIAL
Karen Kan, Sripal Bangalore
No abstract text is available yet for this article.
October 28, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27776800/influence-of-myocardial-ischemia-extent-on-left-ventricular-global-longitudinal-strain-in-patients-after-st-segment-elevation-myocardial-infarction
#8
Aukelien C Dimitriu-Leen, Arthur J H A Scholte, Spyridon Katsanos, Georgette E Hoogslag, Alexander R van Rosendael, Erik W van Zwet, Jeroen J Bax, Victoria Delgado
Two-dimensional echocardiographic left ventricular (LV) global longitudinal strain (GLS) after ST-segment elevation myocardial infarction (STEMI) is moderately correlated with infarct size and reflects the residual LV systolic function. This correlation may be influenced by the presence of myocardial ischemia. The present study investigated how myocardial ischemia modulates the correlation between LV GLS and infarct size determined with single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) in patients with first STEMI treated with primary coronary intervention...
September 30, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27747165/use-of-bio-informatics-assessment-schema-bias-to-improve-diagnosis-and-prognosis-of-myocardial-perfusion-data-results-from-the-nhlbi-sponsored-women-s-ischemia-syndrome-evaluation-wise
#9
Mark Doyle, Gerald M Pohost, C Noel Bairey Merz, Leslee J Shaw, George Sopko, William J Rogers, Barry L Sharaf, Carl J Pepine, Diane V Thompson, Geetha Rayarao, Lindsey Tauxe, Sheryl F Kelsey, Robert W W Biederman
BACKGROUND: We introduce an algorithmic approach to optimize diagnostic and prognostic value of gated cardiac single photon emission computed tomography (SPECT) and magnetic resonance (MR) myocardial perfusion imaging (MPI) modalities in women with suspected myocardial ischemia. The novel approach: bio-informatics assessment schema (BIAS) forms a mathematical model utilizing MPI data and cardiac metrics generated by one modality to predict the MPI status of another modality. The model identifies cardiac features that either enhance or mask the image-based evidence of ischemia...
October 2016: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/27743297/-same-patient-processing-for-multiple-cardiac-spect-studies-2-improving-quantification-repeatability
#10
Guido Germano, Paul B Kavanagh, Terrence D Ruddy, R Glenn Wells, Yuan Xu, Daniel S Berman, Piotr J Slomka
OBJECTIVES: This paper investigates the ability of grouped quantification (an expression of the same-patient processing approach, or SPP) to improve repeatability of measurements in patients with multiple SPECT studies, and evaluates its performance compared to standard quantification in a population of 100 patients undergoing rest, stress, gated rest, and gated stress SPECT MPI. All acquisitions were performed twice, back-to-back, for a total of 800 image datasets (8 per patient). METHODS: Each dataset was automatically processed (a) independently, using standard quantitative software, and (b) as a group, together with the other 7 datasets belonging to the same patient, using an SPP-modified version of the software that registered the images to one another using a downhill simplex algorithm for the search of optimal translation, rotation, and scaling parameters...
October 14, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27743294/-same-patient-processing-for-multiple-cardiac-spect-studies-1-improving-lv-segmentation-accuracy
#11
Guido Germano, Paul B Kavanagh, Mathews B Fish, Mark H Lemley, Yuan Xu, Daniel S Berman, Piotr J Slomka
OBJECTIVES: This paper describes a novel approach (same-patient processing, or SPP) aimed at improving left ventricular segmentation accuracy in patients with multiple SPECT studies, and evaluates its performance compared to conventional processing in a large population of 962 patients undergoing rest and stress electrocardiography-gated SPECT MPI, for a total of 5,772 image datasets (6 per patient). METHODS: Each dataset was independently processed using a standard algorithm, and a shape quality control score (SQC) was produced for every segmentation...
October 14, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27717443/impact-of-gender-on-the-prognostic-value-of-coronary-artery-calcium-in-symptomatic-patients-with-normal-single-photon-emission-computed-tomography-myocardial-perfusion
#12
Elsemiek M Engbers, Jorik R Timmer, Jan Paul Ottervanger, Mohamed Mouden, Siert Knollema, Pieter L Jager
The coronary artery calcium (CAC) score provides independent prognostic value on top of single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). We sought to determine whether the prognostic value of the CAC score in patients with normal SPECT MPI is gender specific. We studied 3,705 consecutive symptomatic patients without a history of coronary artery disease with normal SPECT MPI. All patients underwent concomitant CAC scoring, which was categorized as CAC score 0, 1 to 99, 100 to 399, 400 to 999, or ≥1,000...
August 30, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27677613/routine-evaluation-of-left-ventricular-function-using-czt-spect-with-low-injected-activities-and-limited-recording-times
#13
Marine Claudin, Laetitia Imbert, Wassila Djaballah, Nicolas Veran, Sylvain Poussier, Véronique Roch, Mathieu Perrin, Antoine Verger, Henri Boutley, Gilles Karcher, Pierre-Yves Marie
PURPOSE: Gamma-cameras, with Cadmium-Zinc-Telluride (CZT) detectors, allow to perform myocardial perfusion imaging (MPI) with limited injected activities and recorded times. This study aimed at determining whether the routine assessment of left ventricular (LV) function with such limited counts protocols compares well with reference values from cardiac MRI. METHODS: The study included patients who have undergone cardiac MRI and an MPI routinely planned on a CZT camera with a low-dose protocol (120 MBq of Sestamibi for stress and 360 MBq at rest for 75 kg body weight), while targeting the recording of only 500 myocardial kcounts in order to limit the recording times (<10 minutes for stress, <4 minutes for rest)...
September 27, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27671493/prognosis-of-stress-only-spect-myocardial-perfusion-imaging-with-prone-imaging
#14
Ariel Gutstein, Tamir Bental, Ajejandro Solodky, Israel Mats, Nili Zafrir
BACKGROUND: Stress-only single-photon emission computed tomography myocardial perfusion imaging (SO SPECT MPI) is associated with similarly benign prognosis as stress-rest SPECT MPI. However, previous studies have used attenuation correction rather than prone imaging to increase the rate of SO studies. OBJECTIVES: To assess the prognosis of SO SPECT MPI performed with prone imaging. METHODS: We performed a retrospective cohort analysis of all patients who underwent a Tc-99m gated SPECT MPI over a 58-month period...
September 26, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27663251/prognostic-impact-of-spect-mpi-after-renal-transplantation
#15
Wael Abuzeid, Robert M Iwanochko, Xuesong Wang, S Joseph Kim, Mansoor Husain, Douglas S Lee
BACKGROUND: While renal transplantation is increasingly performed for end-stage renal disease, there is a paucity of data on cardiac screening and prognostication post-transplant. We determined the prognostic value of SPECT-MPI in a cohort who underwent renal transplantation. METHODS: Among 4933 renal transplant recipients identified from the Canadian Organ Replacement Register, we examined outcomes of patients who underwent SPECT-MPI in Ontario, Canada. We determined morbidity and mortality using hospitalization and vital statistics registries, according to SPECT-MPI findings...
September 23, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27663249/the-value-of-transient-ischemic-dilation-for-detecting-restenosis-after-coronary-artery-revascularization
#16
Salih Sinan Gultekin, Murat Sadic, Murat Bilgin, Gökhan Koca, Sadik Acikel, Ekrem Yeter, Meliha Korkmaz
AIM: Transient ischemic dilation (TID) is a marker of severe coronary artery disease (CAD). We aimed to assess the incremental value of TID in a cohort of patients with known significant CAD who had recurrence of symptoms after revascularization. METHODS: We identified in our databases 104 patients who had recent coronary revascularization and recurrence of symptoms. 62 patients had PCI (75 arteries) and 42 patients had CABG (104 arteries). All had follow-up stress SPECT MPI and repeat coronary angiography...
September 23, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27632344/novel-99m-tc-iii-azide-complexes-99m-tc-n3-cdo-cdoh-2b-r-cdoh2-cyclohexanedione-dioxime-as-potential-radiotracers-for-heart-imaging
#17
Min Liu, Yumin Zheng, Ugur Avcibasi, Shuang Liu
INTRODUCTION: In this study, novel (99m)Tc(III)-azide complexes [(99m)Tc(N3)(CDO)(CDOH)2B-R] ((99m)Tc-ISboroxime-N3: R=IS; (99m)Tc-MPboroxime-N3: R=MP; (99m)Tc-PAboroxime-N3: R=PA; (99m)Tc-PYboroxime-N3: R=PY; and (99m)Tc-Uboroxime-N3: R=5U) were evaluated as heart imaging agents. METHODS: Complexes [(99m)Tc(N3)(CDO)(CDOH)2B-R] (R=IS, MP, PA, PY and 5U) were prepared by ligand exchange between NaN3 and [(99m)TcCl(CDO)(CDOH)2B-R]. Biodistribution and imaging studies were carried out in Sprague-Dawley rats...
November 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/27595676/rationale-and-design-of-the-randomized-evaluation-of-patients-with-stable-angina-comparing-utilization-of-noninvasive-examinations-rescue-trial
#18
Arthur E Stillman, Constantine Gatsonis, João A C Lima, William C Black, Jean Cormack, Ilana Gareen, Udo Hoffmann, Tao Liu, Kreton Mavromatis, Mitchell D Schnall, James E Udelson, Pamela K Woodard
RESCUE is a phase III, randomized, controlled, multicenter, comparative efficacy study, designed to compare two diagnostic imaging/treatment paradigms that use coronary computed tomography angiography (CCTA) or single photon emission computed tomography myocardial perfusion imaging (SPECT MPI) for assisting in the diagnosis of ischemic heart disease in patients with stable angina symptoms, and guiding subsequent treatment. The study is based on the hypothesis that CCTA as a diagnostic tool is associated with no increase in cardiac risk, decreased cost, and reduced radiation exposure compared with SPECT MPI...
September 2016: American Heart Journal
https://www.readbyqxmd.com/read/27574382/ranolazine-therapy-reduces-non-st-segment-elevation-myocardial-infarction-and-unstable-angina-in-coronary-disease-patients-with-angina
#19
Gary L Murray, Joseph Colombo
High sympathetic tone and cardiac autonomic neuropathy (CAN) are associated with major adverse cardiac events (MACE). We have shown ranolazine (RAN) improves autonomic function. RAN was introduced to 51 successive anginal CD patients (RANCD). A control group of 54 successive nonanginal CD patients (NORANCD) continued baseline therapy. Mean study duration was 6.1 years, which included semi-annual autonomic function measures (ANX 3.0, ANSAR Medical Technologies, Inc., Philadelphia, PA) and yearly myocardial perfusion SPECT studies (MPI)...
September 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/27550022/the-effect-of-patient-anxiety-and-depression-on-motion-during-myocardial-perfusion-spect-imaging
#20
Vassiliki Lyra, Maria Kallergi, Emmanouil Rizos, Georgios Lamprakopoulos, Sofia N Chatziioannou
BACKGROUND: Patient motion during myocardial perfusion SPECT imaging (MPI) may be triggered by a patient's physical and/or psychological discomfort. The aim of this study was to investigate the impact of state anxiety (patient's reaction to exam-related stress), trait anxiety (patient's personality characteristic) and depression on patient motion during MPI. METHODS: All patients that underwent MPI in our department in a six-month period were prospectively enrolled...
2016: BMC Medical Imaging
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