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SPECT MPI

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https://www.readbyqxmd.com/read/29214612/complete-revascularization-determined-by-myocardial-perfusion-imaging-could-improve-the-outcomes-of-patients-with-stable-coronary-artery-disease-compared-with-incomplete-revascularization-and-no-revascularization
#1
Jiehui Li, Xiubin Yang, Yueqin Tian, Hongxing Wei, Marcus Hacker, Xiang Li, Xiaoli Zhang
OBJECTIVES: To compare the outcomes among patients treated by complete coronary revascularization (CCR) or incomplete coronary revascularization (ICR) and no coronary revascularization (NCR) by myocardial perfusion imaging (MPI), as well as to evaluate the impact of severity of ischemia on patients with coronary artery disease (CAD) by different therapy strategies. BACKGROUND: Using myocardial ischemia severity determined by MPI guiding treatment strategies for CAD patients still lacks strong clinical evidences...
December 6, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29214611/coronary-risk-equivalence-of-diabetes-assessed-by-spect-mpi
#2
Donna Chelle V Morales, Sanjeev P Bhavnani, Alan W Ahlberg, Raja C Pullatt, Deborah M Katten, Donna M Polk, Gary V Heller
BACKGROUND: Several publications and guidelines designate diabetes mellitus (DM) as a coronary artery disease (CAD) risk equivalent. The aim of this investigation was to examine DM cardiac risk equivalence from the perspective of stress SPECT myocardial perfusion imaging (MPI). METHODS AND RESULTS: We examined cardiovascular outcomes (cardiac death or nonfatal MI) of 17,499 patients referred for stress SPECT-MPI. Patients were stratified into four categories: non-DM without CAD, non-DM with CAD, DM without CAD, and DM with CAD, and normal or abnormal perfusion...
December 6, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29209950/spect-myocardial-ischemia-in-the-absence-of-obstructive-cad-contribution-of-the-invasive-assessment-of-microvascular-dysfunction
#3
Loïc Djaïleb, Laurent Riou, Nicolas Piliero, Adrien Carabelli, Estelle Vautrin, Alexis Broisat, Julien Leenhardt, Jacques Machecourt, Daniel Fagret, Gerald Vanzetto, Gilles Barone-Rochette, Catherine Ghezzi
Coronary microvascular dysfunction has recently emerged as a major independent prognostic factor and can be invasively assessed by coronary flow reserve (CFR) and the index of microvascular resistance (IMR). The incremental prognostic value of myocardial ischemia from SPECT myocardial perfusion imaging (MPI) over clinical characteristics, cardiac risk factors, and stress test data for the prediction of hard cardiac events (myocardial infarction and cardiac death) has been well demonstrated over the last two decades regardless of the absence or presence of epicardial CAD...
December 5, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29197024/impact-of-incomplete-ventricular-coverage-on-diagnostic-performance-of-myocardial-perfusion-imaging
#4
Behzad Sharif, Manish Motwani, Reza Arsanjani, Rohan Dharmakumar, Mathews B Fish, Guido Germano, Debiao Li, Daniel S Berman, Piotr Slomka
In the context of myocardial perfusion imaging (MPI) with cardiac magnetic resonance (CMR), there is ongoing debate on the merits of using technically complex acquisition methods to achieve whole-heart spatial coverage, rather than conventional 3-slice acquisition. An adequately powered comparative study is difficult to achieve given the requirement for two separate stress CMR studies in each patient. The aim of this work is to draw relevant conclusions from SPECT MPI by comparing whole-heart versus simulated 3-slice coverage in a large existing dataset...
December 1, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29196789/prediction-of-functional-recovery-after-primary-pci-using-the-estimate-of-myocardial-salvage-in-gated-spect-early-after-acute-myocardial-infarction
#5
Raffaella Calabretta, Angelo Castello, Flavia Linguanti, Francesca Tutino, Alfonso Ciaccio, Cristina Giglioli, Roberto Sciagrà
PURPOSE: Primary percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) aims to achieve myocardial salvage (MS). Because the reference method for measuring MS requires myocardial perfusion imaging (MPI) after tracer injection before PCI, alternative approaches have been proposed, but none has gained wide acceptance. Gated SPECT MPI can assess infarct size (IS), but can also show myocardial stunning. Thus, we compared functional and perfusion abnormalities early after AMI to estimate MS, and to predict left ventricular ejection fraction (LVEF) recovery at follow-up...
December 1, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29186661/sulfonyl-containing-boronate-caps-for-optimization-of-biological-properties-of-99mtc-iii-radiotracers-99mtccl-cdo-cdoh-2b-r-cdoh2-cyclohexanedione-dioxime
#6
Zuoquan Zhao, Min Liu, Wei Fang, Shuang Liu
In this study, different boronate caps were used to optimize biodistribution properties of radiotracers [99mTcCl(CDO)(CDOH)2B-R] (1: R = 3S; 2: R = 3SP; 3: R = 3MS; 4: R = 3DMS; 5: R = 3MSB; 6: R = 3MMS; 7: R = 3MSA; 8: R = 3DMSA; 9: R = 4S; 10: R = 4MS; and 11: R = 4MSB). Among the eleven new 99mTc radiotracers, 2 shows the most promising characteristics of an optimal heart imaging agent. Its initial heart uptake is close to that of 99mTc-Teboroxime, but its heart retention time is significantly longer. Its heart/liver, heart/lung and heart/muscle ratios are also better than those of 99mTc-Teboroxime...
November 29, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29165498/tomographic-magnetic-particle-imaging-of-cancer-targeted-nanoparticles
#7
Hamed Arami, Eric Teeman, Alyssa Troksa, Haydin Bradshaw, Katayoun Saatchi, Asahi Tomitaka, Sanjiv Sam Gambhir, Urs O Häfeli, Denny Liggitt, Kannan M Krishnan
Magnetic Particle Imaging (MPI) is an emerging, whole body biomedical imaging technique, with sub-millimeter spatial resolution and high sensitivity to a biocompatible contrast agent consisting of an iron oxide nanoparticle core and a biofunctionalized shell. Successful application of MPI for imaging of cancer depends on the nanoparticles (NPs) accumulating at tumors at sufficient levels relative to other sites. NPs' physiochemical properties such as size, crystallographic structure and uniformity, surface coating, stability, blood circulation time and magnetization determine the efficacy of their tumor accumulation and MPI signal generation...
November 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/29124673/failure-to-accurately-identify-the-number-of-diseased-coronary-arteries-a-weakness-of-spect-mpi
#8
EDITORIAL
Dennis A Calnon
No abstract text is available yet for this article.
November 9, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29116562/prediction-of-long-term-%C3%A2-10%C3%A2-year-cardiovascular-outcomes-in-heart-transplant-recipients-value-of-stress-technetium-99m-tetrofosmin-myocardial-perfusion-imaging
#9
Jesse F Veenis, Hendrik J Boiten, Jan C van den Berge, Kadir Caliskan, Alex P W M Maat, Roelf Valkema, Alina A Constantinescu, Olivier C Manintveld, Felix Zijlstra, Ron T van Domburg, Arend F L Schinkel
BACKGROUND: Myocardial perfusion imaging (MPI) using single-photon emission computed tomography (SPECT) is useful in the evaluation of cardiac allograft vasculopathy (CAV) in heart transplant (HTx) recipients. The current study evaluated the long-term prognostic value of stress SPECT MPI for predicting all-cause mortality and cardiac events in HTx recipients. METHODS: The study population consisted of 166 HTx recipients (mean age 54 ± 10 years, 84% male) who underwent exercise or dobutamine stress (99m)Tc-tetrofosmin SPECT MPI for the assessment of CAV...
November 7, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29055639/prognostic-value-of-combined-clinical-and-myocardial-perfusion-imaging-data-using-machine-learning
#10
Julian Betancur, Yuka Otaki, Manish Motwani, Mathews B Fish, Mark Lemley, Damini Dey, Heidi Gransar, Balaji Tamarappoo, Guido Germano, Tali Sharir, Daniel S Berman, Piotr J Slomka
OBJECTIVES: This study evaluated the added predictive value of combining clinical information and myocardial perfusion single-photon emission computed tomography (SPECT) imaging (MPI) data using machine learning (ML) to predict major adverse cardiac events (MACE). BACKGROUND: Traditionally, prognostication by MPI has relied on visual or quantitative analysis of images without objective consideration of the clinical data. ML permits a large number of variables to be considered in combination and at a level of complexity beyond the human clinical reader...
October 16, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29043556/incidence-of-atrioventricular-block-with-vasodilator-stress-spect-a-meta-analysis
#11
Efstathia Andrikopoulou, Charity J Morgan, Lizbeth Brice, Navkaranbir S Bajaj, Harish Doppalapudi, Ami E Iskandrian, Fadi G Hage
BACKGROUND: Adenosine or regadenoson are often used with pharmacologic stress testing. Adenosine may trigger atrioventricular block (AVB). Despite its higher selectivity, regadenoson has also been associated with AVB. We studied the incidence of de novo AVB with these agents. METHODS: A comprehensive search of SCOPUS was performed from inception to March 2016. Studies of at least 10 patients, using adenosine and/or regadenoson with SPECT-MPI, reporting rates of AVB were selected for further review...
October 17, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29038153/prospective-validation-of-a-biomarker-based-rule-out-strategy-for-functionally-relevant-coronary-artery-disease
#12
Joan E Walter, Ursina Honegger, Christian Puelacher, Deborah Mueller, Max Wagener, Nicolas Schaerli, Ivo Strebel, Raphael Twerenbold, Jasper Boeddinghaus, Thomas Nestelberger, Lorraine Sazgary, Stella Marbot, Jeanne du Fay de Lavallaz, Christoph Kaiser, Stefan Osswald, Damian Wild, Katharina Rentsch, Michael Zellweger, Tobias Reichlin, Christian Mueller
BACKGROUND: This study aimed to prospectively advance a rule-out strategy for functionally significant coronary artery disease (CAD) by use of high-sensitivity cardiac troponin I (hs-cTnI) from bench to bedside, by application of a 3-step approach: validation in serum, correlation in plasma, and application on a clinical platform. METHODS: Patients without known CAD referred for rest/stress myocardial perfusion single-photon emission tomography/computer tomography (MPI-SPECT/CT) were assigned to 3 consecutive cohorts: validation, correlation, and application...
October 16, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28986773/feasibility-of-combined-risk-stratification-with-coronary-ct-angiography-and-stress-myocardial-spect-in-patients-with-chronic-coronary-artery-disease
#13
Tomonari Kiriyama, Yoshimitsu Fukushima, Hiromitsu Hayashi, Hitoshi Takano, Shin-Ichiro Kumita
OBJECTIVE: To examine the additional prognostic value of coronary CT angiography (CTA) over myocardial perfusion imaging (MPI) in patients with suspected or known coronary artery disease. METHODS: A series of 157 patients (mean age 69 ± 9 years; 76% male; median follow-up 49 months; range 12-82 months) underwent stress MPI with SPECT and coronary CTA within a 6-month interval. Summed stress score (SSS) and summed difference score (SDS) of stress MPI, number of vessels with stenosis, and presence of left main trunk stenosis and high-risk plaques on coronary CTA were examined...
October 6, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28974994/detecting-myocardial-ischemia-with-99mtechnetium-tetrofosmin-myocardial-perfusion-imaging-in-ischemic-stroke
#14
Sotirios Giannopoulos, Sofia Markoula, Chrissa Sioka, Sofia Zouroudi, Maria Spiliotopoulou, Katerina K Naka, Lampros K Michalis, Andreas Fotopoulos, Athanassios P Kyritsis
BACKGROUND: To assess the myocardial status in patients with stroke, employing myocardial perfusion imaging (MPI) with 99mTechnetium-tetrofosmin (99mTc-TF)-single-photon emission computed tomography (SPECT). METHODS: Fifty-two patients with ischemic stroke were subjected to 99mTc-TF-SPECT MPI within 1 month after stroke occurrence. None of the patients had any history or symptoms of coronary artery disease or other heart disease. Myocardial perfusion imaging was evaluated visually using a 17-segment polar map...
October 2017: Neurohospitalist
https://www.readbyqxmd.com/read/28956115/ct-myocardial-perfusion-imaging-ready-for-prime-time
#15
EDITORIAL
Richard A P Takx, Csilla Celeng, U Joseph Schoepf
The detection of functional coronary artery stenosis with coronary CT angiography (CCTA) is suboptimal. Additional CT myocardial perfusion imaging (CT-MPI) may be helpful to identify patients with myocardial ischaemia in whom coronary revascularization therapy would be beneficial. CT-MPI adds incremental diagnostic and prognostic value over obstructive disease on CCTA. It allows for the quantitation of myocardial blood flow and calculation of coronary flow reserve and shows good correlation with (15)O-H2O positron emission tomography and invasive fractional flow reserve...
September 27, 2017: European Radiology
https://www.readbyqxmd.com/read/28924814/the-prognostic-value-of-heart-rate-response-during-vasodilator-stress-myocardial-perfusion-imaging-in-patients-with-end-stage-renal-disease-undergoing-renal-transplantation
#16
Wael AlJaroudi, Chiedozie Anokwute, Ibtihaj Fughhi, Tania Campagnoli, Marwan Wassouf, Aviral Vij, Michael Kharouta, Andrew Appis, Amjad Ali, Rami Doukky
BACKGROUND: In asymptomatic end-stage renal disease (ESRD) patients undergoing vasodilator stress myocardial perfusion imaging (MPI) prior to renal transplantation (RT), the impact of pre-transplant heart rate response (HRR) to vasodilator stress on post-RT outcomes is unknown. METHODS: We analyzed a retrospective cohort of asymptomatic patients with ESRD who underwent a vasodilator stress SPECT-MPI and subsequently received RT. Blunted HRR was defined as HRR <28% for regadenoson stress and <20% for adenosine stress...
September 18, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28865679/quantification-of-myocardial-perfusion-reserve-using-dynamic-spect-images-of-patients-with-chronic-kidney-disease
#17
Noriko Tsuda, Shinya Shiraishi, Fumi Sakamoto, Hideaki Yuki, Koji Ogasawara, Morikatsu Yoshida, Seiji Tomiguchi, Kenichi Tsujita, Yasuyuki Yamashita
BACKGROUND: Chronic kidney disease (CKD) is an independent risk factor for cardiovascular disorders. The aim of this study was to examine whether the quantitatively measured myocardial blood flow (MBF) or myocardial perfusion reserve (MPR), calculated by dynamic single photon emission computed tomography (SPECT) analysis using a cardiac cadmium zinc telluride (CZT) gamma camera, was related to renal dysfunction in patients with normal myocardial perfusion imaging (MPI) findings. METHODS: The study population consisted of 46 patients with CKD and 46 individuals without CKD (controls)...
August 30, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28822102/effect-of-a-patient-specific-minimum-activity-in-stress-myocardial-perfusion-imaging-using-czt-spect-prognostic-value-radiation-dose-and-scan-outcome
#18
J D van Dijk, N M Borren, M Mouden, J A van Dalen, J P Ottervanger, P L Jager
BACKGROUND: SPECT Myocardial perfusion imaging (MPI) is associated with a relatively high radiation burden and decreasing image quality in heavy patients. Patient-specific low-activity protocols (PLAPs) are suggested but follow-up data is lacking. Our aim was to compare the use of a standard fixed-activity protocol (FAP) with a PLAP in cadmium zinc telluride (CZT)-SPECT MPI. METHODS: We retrospectively included 1255 consecutive patients who underwent CZT-SPECT stress-optional rest MPI...
August 18, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28776314/a-combined-static-dynamic-single-dose-imaging%C3%A2-protocol-to-compare-quantitative-dynamic-spect-with-static-conventional-spect
#19
Maria Sciammarella, Uttam M Shrestha, Youngho Seo, Grant T Gullberg, Elias H Botvinick
BACKGROUND: SPECT myocardial perfusion imaging (MPI) is a clinical mainstay that is typically performed with static imaging protocols and visually or semi-quantitatively assessed for perfusion defects based upon the relative intensity of myocardial regions. Dynamic cardiac SPECT presents a new imaging technique based on time-varying information of radiotracer distribution, which permits the evaluation of regional myocardial blood flow (MBF) and coronary flow reserve (CFR). In this work, a preliminary feasibility study was conducted in a small patient sample designed to implement a unique combined static-dynamic single-dose one-day visit imaging protocol to compare quantitative dynamic SPECT with static conventional SPECT for improving the diagnosis of coronary artery disease (CAD)...
August 3, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28776313/a-new-era-in-gated-myocardial-perfusion-imaging-feasibility-of-data-driven-cardiac-contraction-gating-with-multiple-pinhole-czt-spect
#20
Doumit Daou, Rémy Sabbah, Carlos Coaguila, Yousef Alattar, Hatem Boulahdour
BACKGROUND: We previously validated the use of a data-driven cardiac respiratory-motion (RM) correction method (REGAT) applicable to CZT SPECT myocardial perfusion imaging (MPI). In this study, we adapted the same process used with REGAT for RM to generate data-driven cardiac contraction triggers and corresponding cardiac contraction-gated SPECT studies (GSPECT-DD). We aimed to study its feasibility and compare its performances to GSPECT studies generated with ECG monitor-based triggers (GSPECT-ECG)...
August 3, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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