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SPECT MPI

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https://www.readbyqxmd.com/read/28699019/the-diagnostic-performance-of-spect-mpi-to-predict-functional-significant-coronary-artery-disease-by-fractional-flow-reserve-derived-from-ccta-ffrct-sub-analysis-from-accuracy-and-vct001-studies
#1
Rine Nakanishi, Kazuhiro Osawa, Indre Ceponiene, Glenn Huth, Jason Cole, Michael Kim, Negin Nezarat, Sina Rahmani, Dong Li, Souma Gupta, Campbell Rogers, Christopher Dailing, Matthew J Budoff
Although single photon emission computed tomography-myocardial perfusion image (SPECT-MPI) and fractional flow reserve (FFR) derived from coronary computed tomographic angiography (CCTA) (FFRCT) have permitted functional assessment of coronary artery disease (CAD), the concordance between these modalities has not been well described. The aim of this study is to compare SPECT-MPI and anatomical stenosis by CCTA and invasive coronary angiography to FFRCT for assessing functional significance of CAD. We identified 62 patients with suspected CAD who underwent ≥64 slice coronary CTA and SPECT-MPI within 3 months...
July 11, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28695497/comparison-of-ctac-and-prone-imaging-for-the-detection-of-coronary-artery-disease-using-czt-spect
#2
Shimpei Ito, Akihiro Endo, Taiji Okada, Taku Nakamura, Takashi Sugamori, Nobuyuki Takahashi, Hiroyuki Yoshitomi, Kazuaki Tanabe
BACKGROUND: Cadmium-zinc-telluride (CZT) cameras have improved the evaluation of patients with chest pain. However, inferior/inferolateral attenuation artifacts similar to those seen with conventional Anger cameras persist. We added prone acquisitions and CT attenuation correction (CTAC) to the standard supine image acquisition and analyzed the resulting examinations. METHODS AND RESULTS: Seventy-two patients referred for invasive coronary angiography (CAG), and who also underwent rest/stress myocardial perfusion imaging (MPI) on a CZT camera in the supine and prone positions plus CTAC imaging, to examine known or suspected CAD between April 2013 and March 2014 were included...
July 10, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28695407/nuclear-cardiology-in-china-2017
#3
Gongshun Tang
This paper provides the current state of nuclear cardiology in China and contrasts it with the state of nuclear cardiology in the United States (US). The West China Hospital and New York-Presbyterian Hospital (NYPH) were used as representative hospitals to contrast nuclear cardiology in China and the US, respectively. In 2015, there were 101 medical cyclotrons, 774 SPECT or SPECT/CT, 240 PET/CT, and 6 PET/MR cameras in China. Most (~90%) of the nuclear cardiology studies are gated SPECT myocardial perfusion imaging (MPI), and ~10% are other types of studies including MUGA, PET/CT MPI, and viability studies...
July 10, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28685253/detection-and-quantitation-of-right-ventricular-reversible-perfusion-defects-by-stress-spect-myocardial-perfusion-imaging-a-proof-of-principle-study
#4
Ayman A Farag, Jack Heo, Lindsey Tauxe, Pradeep Bhambhvani, Guido Germano, Paul Kavanagh, Ami E Iskandrian, Fadi G Hage
BACKGROUND: In patients with right dominant coronary circulation, the right ventricular (RV) myocardium and the inferior region of the left ventricular (LV) myocardium share a common source of blood flow. We hypothesized that stress/rest SPECT myocardial perfusion imaging (MPI) could detect reversible perfusion defects in the RV in some patients with LV inferior wall perfusion abnormalities. MATERIAL AND METHODS: We identified 2 groups of patients with LV inferior wall perfusion defects (with or without defects in other regions of LV myocardium) from our database...
July 6, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28685228/relationship-between-coronary-contrast-flow-quantitative-flow-ratio-and-myocardial-ischemia-assessed-by-spect-mpi
#5
Jeff M Smit, Gerhard Koning, Alexander R van Rosendael, Petra Dibbets-Schneider, Bart J Mertens, J Wouter Jukema, Victoria Delgado, Johan H C Reiber, Jeroen J Bax, Arthur J Scholte
PURPOSE: A new method has been developed to calculate fractional flow reserve (FFR) from invasive coronary angiography, the so-called "contrast-flow quantitative flow ratio (cQFR)". Recently, cQFR was compared to invasive FFR in intermediate coronary lesions showing an overall diagnostic accuracy of 85%. The purpose of this study was to investigate the relationship between cQFR and myocardial ischemia assessed by single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI)...
July 6, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28685008/stress-spect-myocardial-perfusion-imaging-in-end-stage-renal-disease
#6
Yasmeen Golzar, Rami Doukky
PURPOSE OF REVIEW: Patients with end-stage renal disease (ESRD) have an increased risk of cardiovascular morbidity and mortality. Cardiac risk assessment, though challenging, is critical in these high-risk patients, particularly in the pre-transplant population. In this review, we discuss the burden of coronary artery disease in the ESRD population and review the literature on the diagnostic and prognostic performance, clinical value, and future directions of single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) in ESRD patients...
May 2017: Current Cardiovascular Imaging Reports
https://www.readbyqxmd.com/read/28680199/diagnostic-accuracy-of-stress-myocardial-perfusion-imaging-in-indian-diabetic-patients-a-single-centre-experience
#7
Deepa Kumar, Ravinder Singh Sethi, Sandeep Bansal, Padma A Namgyal, Aditi Khurana Sehgal, Tajamul Syed Malik
Diabetics have around 2-4 times increased risk of coronary artery disease(CAD) and it is the most important cause of mortality in these patients. This study was carried out to compare the sensitivity, specificity and accuracy of MPI-SPECT among diabetics and non-diabetics in the Indian population. MATERIAL AND METHODS: This retrospective study included 261 patients; 213 males and 48 females, with 75 diabetic and 186 non-diabetic patients. Only type II diabetics and non-diabetic patients were included in the study...
July 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28670181/transient-ischemic-dilation-ratio-in-regadenoson-single-isotope-gated-single-photon-emission-computed-tomography-myocardial-perfusion-imaging
#8
Manolo Rubio, Andre Dias, Nikoloz Koshkelashvili, Jose N Codolosa, Mauricio Jalife-Bucay, Mary Rodriguez-Ziccardi, Aman M Amanullah
Single isotope 99mTc single-photon emission computed tomography-myocardial perfusion imaging (SPECT-MPI) is the most commonly used protocol for nuclear stress testing. Transient ischemic dilation of the left ventricle (TID) has been considered a specific marker of severe coronary artery disease (CAD). Recent publications have questioned the clinical utility of TID, specifically with regadenoson as a stressor and 4DM-SPECT software for TID analysis. These findings have not been demonstrated using other imaging packages...
July 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28664481/comparison-of-conventional-and-cadmium-zinc-telluride-single-photon-emission-computed-tomography-for-analysis-of-thallium-201-myocardial-perfusion-imaging-an-exploratory-study-in-normal-databases-for-different-ethnicities
#9
Masaru Ishihara, Masahisa Onoguchi, Yasuyo Taniguchi, Takayuki Shibutani
The aim of this study was to clarify the differences in thallium-201-chloride (thallium-201) myocardial perfusion imaging (MPI) scans evaluated by conventional anger-type single-photon emission computed tomography (conventional SPECT) versus cadmium-zinc-telluride SPECT (CZT SPECT) imaging in normal databases for different ethnic groups. MPI scans from 81 consecutive Japanese patients were examined using conventional SPECT and CZT SPECT and analyzed with the pre-installed quantitative perfusion SPECT (QPS) software...
June 29, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28653271/regadenoson-use-in-chronic-kidney-disease-and-end-stage-renal-disease-a-focused-review
#10
Aviral Vij, Yasmeen Golzar, Rami Doukky
Regadenoson is a selective A2A adenosine receptor agonist that has been approved as a vasodilator stress agent with single-photon emission-computed tomography (SPECT) myocardial perfusion imaging (MPI). Since its approval by the Food and Drug Administration (FDA) in 2008, it has become the most commonly used pharmacologic stress agent with SPECT-MPI. Given that it is predominantly renally excreted, its use in patients with chronic kidney disease has been the subject of active post-marketing clinical research...
June 26, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28647935/evaluation-of-patients-with-acute-chest-pain-using-spect-myocardial-perfusion-imaging-prognostic-implications-of-mildly-abnormal-scans
#11
Ronen Goldkorn, Alexey Naimushin, Roy Beigel, Ekaterina Naimushin, Michael Narodetski, Shlomi Matetzky
BACKGROUND: While patients presenting to emergency departments (ER) with chest pain are increasingly managed in chest pain units (CPU) that utilize accelerated diagnostic protocols for risk stratification, such as single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI), data are lacking regarding the prognostic implications of mildly abnormal scans in this population. OBJECTIVES: To evaluate the prognostic implications of mildly abnormal SPECT MPI results in patients with acute chest pain...
June 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28622946/estimation-of-myocardial-flow-reserve-utilizing-an-ultrafast-cardiac-spect-comparison-with-coronary-angiography-fractional-flow-reserve-and-the-syntax-score
#12
Masao Miyagawa, Yoshiko Nishiyama, Teruyoshi Uetani, Akiyoshi Ogimoto, Shuntaro Ikeda, Hayato Ishimura, Emiri Watanabe, Rami Tashiro, Yuki Tanabe, Teruhito Kido, Akira Kurata, Teruhito Mochizuki
BACKGROUND: Quantitative assessment of myocardial flow reserve (MFR) by single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is challenging but may facilitate evaluation of multi-vessel coronary artery disease (CAD). METHODS: We enrolled 153 patients with suspected or known CAD, referred for pharmacological stress MPI. They underwent a (99m)Tc-perfusion stress/rest SPECT with an ultrafast cadmium-zinc-telluride (CZT) camera. Dynamic data were acquired and time-activity curves fitted to a 1-tissue compartment analysis with input function...
June 13, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28622166/quantitative-analysis-of-iodine-image-of-dual-energy-computed-tomography-at-rest-comparison-with-99mtc-tetrofosmin-stress-rest-single-photon-emission-computed-tomography-myocardial-perfusion-imaging-as-the-reference-standard
#13
Takehiro Nakahara, Takuji Toyama, Masahiro Jinzaki, Ryotaro Seki, Yuichiro Saito, Tetsuya Higuchi, Minoru Yamada, Masashi Arai, Yoshito Tsushima, Sachio Kuribayashi, Masahiko Kurabayashi
PURPOSE: Dual-energy computed tomography (DECT) can be used for visual determination of iodine distribution in the myocardium (iodine image); however, the accuracy and reproducibility of the process remains debatable. Because of the low contrast-to-noise ratio of CT, we hypothesized that quantitative measurement may be more accurate for detecting myocardial ischemia. In this study, we evaluated our quantitative method by comparing it with visual analysis using Tc-tetrofosmin (TF) stress-rest single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) as the reference standard...
June 15, 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28611231/validation-of-the-left-ventricular-ejection-fraction-with-iq-spect-system-in-small-heart-patients
#14
Hiroto Yoneyama, Takayuki Shibutani, Takahiro Konishi, Asuka Mizutani, Hashimoto Ryosuke, Masahisa Onoguchi, Koichi Okuda, Shinro Matsuo, Kenichi Nakajima, Kinuya Seigo
The IQ-SPECT system equipped with a multifocal (SMARTZOOM) collimator using an ordered subset conjugate gradient minimization (OSCGM) algorithm reduces the acquisition time of myocardial perfusion imaging (MPI) compared to conventional gamma cameras equipped with low-energy high-resolution (LEHR) collimators. We compared IQ-SPECT with a conventional single-photon emission computed tomography (SPECT) system for estimating the left ventricular ejection fraction (LVEF) in small-heart patients. Methods: The study group consisted of 98 consecutive patients who underwent a 1-day stress-rest MPI study with a (99m)Tc-labeled agent for preoperative risk assessment...
June 13, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28608184/assessment-of-left-ventricular-contraction-patterns-using-gated-spect-mpi-to-predict-cardiac-resynchronization-therapy-response
#15
Ningchao Tao, Yuanhao Qiu, Haipeng Tang, Zhiyong Qian, Hongping Wu, Rui Zhu, Yao Wang, Xiaofeng Hou, Weihua Zhou, Jiangang Zou
BACKGROUND: The U-shaped left ventricular (LV) contraction pattern, identified by MRI or echocardiography, is associated with improved CRT response. Gated SPECT MPI can measure both myocardial viability and mechanical dyssynchrony in a single scan. The aim of this study is to examine the relationship of the LV contraction pattern and the response of CRT in patients with left bundle branch block (LBBB). METHODS: Fifty-eight patients who met CRT guidelines and who had pre-CRT MPI were enrolled...
June 12, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28585034/myocardial-perfusion-imaging-in-women-for-the-evaluation-of-stable-ischemic-heart-disease-state-of-the-evidence-and-clinical-recommendations
#16
Viviany R Taqueti, Sharmila Dorbala, David Wolinsky, Brian Abbott, Gary V Heller, Timothy M Bateman, Jennifer H Mieres, Lawrence M Phillips, Nanette K Wenger, Leslee J Shaw
This document from the American Society of Nuclear Cardiology represents an updated consensus statement on the evidence base of stress myocardial perfusion imaging (MPI), emphasizing new developments in single-photon emission tomography (SPECT) and positron emission tomography (PET) in the clinical evaluation of women presenting with symptoms of stable ischemic heart disease (SIHD). The clinical evaluation of symptomatic women is challenging due to their varying clinical presentation, clinical risk factor burden, high degree of comorbidity, and increased risk of major ischemic heart disease events...
June 5, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28575215/comparison-of-the-effects-of-selective-and-non-selective-his-bundle-pacing-on-cardiac-electrical-and-mechanical-synchrony
#17
Jinlong Zhang, Jianghong Guo, Xiaofeng Hou, Yao Wang, Zhiyong Qian, Kebei Li, Peibing Ge, Jiangang Zou
Aims: This study aimed to assess the acute effect of selective His bundle pacing (S-HBP), non-selective His bundle pacing (NS-HBP), and right ventricular septum pacing (RVSP) on electrical synchrony and left ventricular (LV) mechanical synchrony using electrocardiogram and phase analysis of gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). Methods and results: Totally 39 patients eligible for pacemaker were enrolled. Thirty-seven patients underwent successful His bundle pacing (HBP) including S-HBP in 23 and NS-HBP in 14 patients, respectively...
May 31, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28540215/myocardial-flow-reserve-mfr-with-positron-emission-tomography-pet-computed-tomography-ct-clinical-impact-in-diagnosis-and-prognosis
#18
REVIEW
Maria Cecilia Ziadi
In recent years, radionuclide myocardial perfusion imaging (MPI) using positron emission tomography/computed tomography (PET/CT) has emerged as a robust tool for the diagnosis, risk stratification and management of patients with known or established coronary artery disease (CAD). Cardiac PET/CT imaging affords key advantages compared to single photon emission computed tomography (SPECT) that encompass: (I) improved diagnostic accuracy; (II) decreased radiation exposure due to the utilization of short-lived radiopharmaceuticals, and importantly; (III) the ability to quantify noninvasively myocardial blood flow (MBF) in absolute terms, that is in ml per minute per gram of tissue...
April 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28537039/investigation-of-dose-reduction-in-cardiac-perfusion-spect-via-optimization-and-choice-of-the-image-reconstruction-strategy
#19
Albert Juan Ramon, Yongyi Yang, P Hendrik Pretorius, Piotr J Slomka, Karen L Johnson, Michael A King, Miles N Wernick
BACKGROUND: We investigated the extent to which the administered dose (activity) level can be reduced without sacrificing diagnostic accuracy for three reconstruction strategies for SPECT-myocardial perfusion imaging (MPI). METHODS: We optimized the parameters of the three reconstruction strategies for perfusion-defect detection over a range of simulated administered dose levels using a set of hybrid studies (derived from 190 subjects) consisting of clinical SPECT-MPI data modified to contain realistic simulated lesions...
May 23, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28508270/the-impact-of-combined-cardiopulmonary-exercise-testing-and-spect-myocardial-perfusion-imaging-on-downstream-evaluation-and-management
#20
Georgios Christopoulos, John Bois, Thomas G Allison, Martin Rodriguez-Porcel, Panithaya Chareonthaitawee
OBJECTIVE: The diagnostic yield of combined cardiopulmonary exercise testing (CPET) and myocardial perfusion imaging (MPI) in patients referred for stress testing has received limited study. METHODS: We evaluated consecutive patients who underwent combined CPET-MPI at a single tertiary referral center between 2011 and 2015. An abnormal CPET was defined as any of the following: reduced oxygen consumption, cardiac output impairment, or pulmonary impairment. Normal MPI was defined as the absence of resting or stress perfusion defect...
May 15, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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