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SPECT MPI

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https://www.readbyqxmd.com/read/28077904/regadenoson-in-myocardial-perfusion-study-first-institutional-experiences-in-bosnia-and-herzegovina
#1
Nermina Beslic, Renata Milardovic, Amera Sadija, Sejla Ceric, Zeljka Raic
INTRODUCTION: Myocardial perfusion imaging (MPI) is widely used in the evaluation of known and suspected coronary artery disease (CAD). Imaging of heart in stress and rest enables the comparison of myocardial uptake of radiotracer in proportion to the needs and coronary flow, which is used for detection of perfusion defects. Exercise stress and pharmacologic agents are used for the stressing purpose. Novel pharmacologic stressor regadenoson is A2A selective adenosine agonist, which selectively binds to the adenosine receptors in coronary arteries causing coronary dilatation...
December 2016: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28050863/incremental-prognostic-value-of-spect-mpi-in-chronic-kidney-disease-a-reclassification-analysis
#2
Amjad M Ahmed, Waqas T Qureshi, Wesley T O'Neal, Fatima Khalid, Mouaz H Al-Mallah
BACKGROUND: Traditional cardiovascular (CV) risk factors have limited predictive value of CV mortality in patients with chronic kidney disease (CKD, creatinine clearance less than 60 mL/minute per 1.73 m(2)). The aim of this study was to evaluate incremental and independent prognostic value of single-photon emission computerized tomography-myocardial perfusion imaging (SPECT-MPI) across continuum of renal function. METHODS: We retrospectively studied 11,518 (mean age, 65 ± 12 years; 52% were men) patients referred for a clinical indication of SPECT-MPI between April 2004 and May 2009...
January 3, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28032913/correction-of-hysteretic-respiratory-motion-in-spect-myocardial-perfusion-imaging-simulation-and-patient-studies
#3
Paul K R Dasari, Arda Könik, P Hendrik Pretorius, Karen L Johnson, William P Segars, Mohammed S Shazeeb, Michael A King
PURPOSE: Amplitude based respiratory gating is known to capture the extent of respiratory motion (RM) accurately but results in residual motion in the presence of respiratory hysteresis. In our previous study, we proposed and developed a novel approach to account for respiratory hysteresis by applying the Bouc-Wen (BW) model of hysteresis to external surrogate signals of anterior / posterior motion of the abdomen and chest with respiration. In this work using simulated and clinical SPECT myocardial perfusion imaging (MPI) studies, we investigate the effects of respiratory hysteresis and evaluate the benefit of correcting it using the proposed BW model in comparison with the abdomen signal typically employed clinically...
December 29, 2016: Medical Physics
https://www.readbyqxmd.com/read/28025263/quantitative-plaque-features-from-coronary-computed-tomography-angiography-to-identify-regional-ischemia-by-myocardial-perfusion-imaging
#4
Mariana Diaz-Zamudio, Tobias A Fuchs, Piotr Slomka, Yuka Otaki, Reza Arsanjani, Heidi Gransar, Guido Germano, Daniel S Berman, Philipp A Kaufmann, Damini Dey
AIMS: We aimed to investigate whether quantitative plaque features measured from coronary CT angiography (CCTA) predict ischemia by myocardial perfusion SPECT imaging (MPI). METHODS AND RESULTS: Hundred and eighty-four consecutive patients (63% males) with suspected-coronary artery disease, undergoing hybrid CCTA, and attenuation corrected solid state (99m)Tc stress/rest MPI and single vessel ischemia were considered. Quantitative analysis of CCTA derived non-calcified plaque (NCP), low-density NCP [< 30 Hounsfield Units (HU)] (LDNCP), calcified and total plaque burdens (%, normalized to vessel volume), maximum diameter stenosis and contrast density difference (CD, maximum difference in HU/lumen area within lesion)...
December 26, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28012120/improvement-in-automated-quantitation-of-myocardial-perfusion-abnormality-by-using-iterative-reconstruction-image-in-combination-with-resolution-recovery-attenuation-and-scatter-corrections-for-the-detection-of-coronary-artery-disease
#5
Taiki Chono, Masahisa Onoguchi, Takayuki Shibutani, Akiyoshi Hashimoto, Tomoaki Nakata, Naoya Yama, Kazufumi Tsuchihashi, Masamitsu Hatakenaka
OBJECTIVE: An iterative reconstruction method in combination with resolution recovery, attenuation and scatter corrections (IR-RASC) can improve image quality. It, however, is undetermined whether this technique can improve the detection of coronary artery disease (CAD) when automated quantitative analysis is used. This study evaluated diagnostic values of IR-RASC in combination with automated quantitative analysis in stress myocardial perfusion imaging (MPI) in the CAD detection. METHODS: This study enrolled consecutive 64 patients (mean age 66...
December 24, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27987028/left-ventricular-function-in-response-to-dipyridamole-stress-head-to-head-comparison-between-82-rubidium-pet-and-99m-tc-sestamibi-spect-ecg-gated-myocardial-perfusion-imaging
#6
Maria Clementina Giorgi, Jose Claudio Meneghetti, Jose Soares, Marisa Izaki, Andréa Falcão, Rodrigo Imada, William Chalela, Marco Antonio de Oliveira, Cesar Nomura, Hein J Verberne
PURPOSE: Myocardial perfusion imaging (MPI) with (99m)Tc-sestamibi (sestamibi) SPECT and rubidium-82 ((82)Rb) PET both allow for combined assessment of perfusion and left ventricular (LV) function. We sought to compare parameters of LV function obtained with both methods using a single dipyridamole stress dose. MATERIALS AND METHODS: A group of 221 consecutive patients (65.2 ± 10.4 years, 52.9% male) underwent consecutive sestamibi and (82)Rb MPI after a single dipyridamole stress dose...
December 16, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27900642/ischemia-burden-on-stress-spect-mpi-predicts-long-term-outcomes-after-revascularization-in-stable-coronary-artery-disease
#7
Hendrik J Boiten, Jan C van den Berge, Roelf Valkema, Ron T van Domburg, Felix Zijlstra, Arend F L Schinkel
BACKGROUND: It is not entirely clear whether ischemia burden on stress single-photon emission computed tomography (SPECT) effectively identifies patients who have a long-term benefit from coronary revascularization. METHODS: The study population consisted of 719 patients with ischemia on stress SPECT. Early coronary revascularization was defined as percutaneous coronary intervention or coronary artery bypass grafting ≤90 days after SPECT. Patients who underwent late revascularization (>90 days after SPECT) were excluded (n = 164)...
November 29, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27858346/single-ct-for-attenuation-correction-of-rest-stress-cardiac-spect-perfusion-imaging
#8
R Glenn Wells, Mikael Trottier, Manuja Premaratne, Karen Vanderwerf, Terrence D Ruddy
Common practice is to use separate CT scans acquired during rest and stress for attenuation correction of SPECT myocardial perfusion imaging (MPI). We evaluated using a single CT scan to correct both rest and stress SPECT scans. Studies from 154 patients were reprocessed using one CT acquired at stress to correct both rest and stress scans (1CT) and compared to correction of each scan with its own CT (2CT). Two expert readers independently read the images and determined summed stress (SSS), rest (SRS), and difference (SDS) scores...
November 17, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27858344/association-between-non-perfusion-parameters-and-presence-of-ischemia-in-gated-spect-myocardial-perfusion-imaging-studies
#9
Amalia Peix, Lázaro O Cabrera, Kenia Padrón, Lydia Rodríguez, Jesús Fernández, Giselle López, Regla Carrillo, Erick Mena, Yoel Fernández, Maurizio Dondi, Diana Páez
BACKGROUND: Combined assessment of perfusion and function improves diagnostic and prognostic power of gated-SPECT in patients with coronary artery disease. The aim of this study was to investigate whether the presence of stress-induced ischemia is associated with abnormal resting left ventricular (LV) function and intraventricular dyssynchrony. METHODS AND RESULTS: Gated-SPECT myocardial perfusion imaging (MPI) at rest and 15 min post-stress was performed in 101 patients, who were divided into three groups: those with stress-induced ischemia (Group 1, n = 58), those with normal scans (Group 2, n = 28), and those with scar but no ischemia (Group 3, n = 15)...
November 17, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27834038/artifacts-in-quantitative-analysis-of-myocardial-perfusion-spect-using-cedars-sinai-qps-software
#10
Hadi Malek, Nahid Yaghoobi, Raheleh Hedayati
Quantitative analysis of myocardial perfusion Single photon emission computerized tomography (SPECT) images is increasingly applied in modern nuclear cardiology practice, assisting in the interpretation of myocardial perfusion images (MPI). There are different extensively validated state-of-the-art software packages, including QPS (cedars-Sinai), Corridor 4DM (University of Michigan) and Emory cardiac toolbox (Emory university), providing highly accurate and reproducible data. However, these software packages may suffer from potential artifacts related to patient or technical factors...
November 10, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27811121/automatic-valve-plane-localization-in-myocardial-perfusion-spect-ct-by-machine-learning-anatomical-and-clinical-validation
#11
Julian Betancur, Mathieu Rubeaux, Tobias Fuchs, Yuka Otaki, Yoav Arnson, Leandro Slipczuk, Dominik Benz, Guido Germano, Damini Dey, Chih-Jen Lin, Daniel Berman, Philipp Kaufmann, Piotr Slomka
: Precise definition of the mitral valve plane (VP) during segmentation of the left ventricle (LV) for single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) quantification often requires manual adjustment, which affects quantification of perfusion. We developed a machine learning approach using support vector machines (SVM) for automatic VP placement. METHODS: 392 consecutive patients undergoing fast SPECT MPI (99m)Tc-tetrofosmin stress (5 min, 300-350 MBq)/rest (5 min, 750-1050 MBq) attenuation corrected (AC) by computed tomography (CT) and same‑day coronary CT angiography (CCTA), including 48 patients with invasive angiography (ICA) and no known coronary artery disease, were studied...
November 3, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27796852/functional-compared-to-anatomical-imaging-in-the-initial-evaluation-of-patients-with-suspected-coronary-artery-disease-an-international-multi-center-randomized-controlled-trial-iaea-spect-cta-study
#12
Ganesan Karthikeyan, Barbara Guzic Salobir, Borut Jug, Niveditha Devasenapathy, Erick Alexanderson, Joao Vitola, Otakar Kraft, Elgin Ozkan, Saket Sharma, Gaurav Purohit, Maja Dolenc Novak, Aloha Meave, Sergio Trevethan, Rodrigo Cerci, Sandra Zier, Lucia Gotthardtová, Tomáš Jonszta, Timucin Altin, Cigdem Soydal, Chetan Patel, Gurpreet Gulati, Diana Paez, Maurizio Dondi, Ravi Kashyap
OBJECTIVE: To test the hypothesis that, in the initial evaluation of patients with suspected coronary artery disease (CAD), stress myocardial perfusion imaging (MPI) would result in less downstream testing than coronary computed tomographic angiography (CCTA). METHODS: In this international, randomized trial, mildly symptomatic patients with an intermediate likelihood of having CAD, and asymptomatic patients at intermediate risk of cardiac events, underwent either initial stress-rest MPI or CCTA...
October 28, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27796850/cardiovascular-risk-stratification-after-renal-transplant-is-spect-mpi-the-answer
#13
EDITORIAL
Karen Kan, Sripal Bangalore
No abstract text is available yet for this article.
October 28, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27776800/influence-of-myocardial-ischemia-extent-on-left-ventricular-global-longitudinal-strain-in-patients-after-st-segment-elevation-myocardial-infarction
#14
Aukelien C Dimitriu-Leen, Arthur J H A Scholte, Spyridon Katsanos, Georgette E Hoogslag, Alexander R van Rosendael, Erik W van Zwet, Jeroen J Bax, Victoria Delgado
Two-dimensional echocardiographic left ventricular (LV) global longitudinal strain (GLS) after ST-segment elevation myocardial infarction (STEMI) is moderately correlated with infarct size and reflects the residual LV systolic function. This correlation may be influenced by the presence of myocardial ischemia. The present study investigated how myocardial ischemia modulates the correlation between LV GLS and infarct size determined with single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) in patients with first STEMI treated with primary coronary intervention...
January 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/27747165/use-of-bio-informatics-assessment-schema-bias-to-improve-diagnosis-and-prognosis-of-myocardial-perfusion-data-results-from-the-nhlbi-sponsored-women-s-ischemia-syndrome-evaluation-wise
#15
Mark Doyle, Gerald M Pohost, C Noel Bairey Merz, Leslee J Shaw, George Sopko, William J Rogers, Barry L Sharaf, Carl J Pepine, Diane V Thompson, Geetha Rayarao, Lindsey Tauxe, Sheryl F Kelsey, Robert W W Biederman
BACKGROUND: We introduce an algorithmic approach to optimize diagnostic and prognostic value of gated cardiac single photon emission computed tomography (SPECT) and magnetic resonance (MR) myocardial perfusion imaging (MPI) modalities in women with suspected myocardial ischemia. The novel approach: bio-informatics assessment schema (BIAS) forms a mathematical model utilizing MPI data and cardiac metrics generated by one modality to predict the MPI status of another modality. The model identifies cardiac features that either enhance or mask the image-based evidence of ischemia...
October 2016: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/27743297/-same-patient-processing-for-multiple-cardiac-spect-studies-2-improving-quantification-repeatability
#16
Guido Germano, Paul B Kavanagh, Terrence D Ruddy, R Glenn Wells, Yuan Xu, Daniel S Berman, Piotr J Slomka
OBJECTIVES: This paper investigates the ability of grouped quantification (an expression of the same-patient processing approach, or SPP) to improve repeatability of measurements in patients with multiple SPECT studies, and evaluates its performance compared to standard quantification in a population of 100 patients undergoing rest, stress, gated rest, and gated stress SPECT MPI. All acquisitions were performed twice, back-to-back, for a total of 800 image datasets (8 per patient). METHODS: Each dataset was automatically processed (a) independently, using standard quantitative software, and (b) as a group, together with the other 7 datasets belonging to the same patient, using an SPP-modified version of the software that registered the images to one another using a downhill simplex algorithm for the search of optimal translation, rotation, and scaling parameters...
October 14, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27743294/-same-patient-processing-for-multiple-cardiac-spect-studies-1-improving-lv-segmentation-accuracy
#17
Guido Germano, Paul B Kavanagh, Mathews B Fish, Mark H Lemley, Yuan Xu, Daniel S Berman, Piotr J Slomka
OBJECTIVES: This paper describes a novel approach (same-patient processing, or SPP) aimed at improving left ventricular segmentation accuracy in patients with multiple SPECT studies, and evaluates its performance compared to conventional processing in a large population of 962 patients undergoing rest and stress electrocardiography-gated SPECT MPI, for a total of 5,772 image datasets (6 per patient). METHODS: Each dataset was independently processed using a standard algorithm, and a shape quality control score (SQC) was produced for every segmentation...
October 14, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27717443/impact-of-gender-on-the-prognostic-value-of-coronary-artery-calcium-in-symptomatic-patients-with-normal-single-photon-emission-computed-tomography-myocardial-perfusion
#18
Elsemiek M Engbers, Jorik R Timmer, Jan Paul Ottervanger, Mohamed Mouden, Siert Knollema, Pieter L Jager
The coronary artery calcium (CAC) score provides independent prognostic value on top of single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). We sought to determine whether the prognostic value of the CAC score in patients with normal SPECT MPI is gender specific. We studied 3,705 consecutive symptomatic patients without a history of coronary artery disease with normal SPECT MPI. All patients underwent concomitant CAC scoring, which was categorized as CAC score 0, 1 to 99, 100 to 399, 400 to 999, or ≥1,000...
August 30, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27677613/routine-evaluation-of-left-ventricular-function-using-czt-spect-with-low-injected-activities-and-limited-recording-times
#19
Marine Claudin, Laetitia Imbert, Wassila Djaballah, Nicolas Veran, Sylvain Poussier, Véronique Roch, Mathieu Perrin, Antoine Verger, Henri Boutley, Gilles Karcher, Pierre-Yves Marie
PURPOSE: Gamma-cameras, with Cadmium-Zinc-Telluride (CZT) detectors, allow to perform myocardial perfusion imaging (MPI) with limited injected activities and recorded times. This study aimed at determining whether the routine assessment of left ventricular (LV) function with such limited counts protocols compares well with reference values from cardiac MRI. METHODS: The study included patients who have undergone cardiac MRI and an MPI routinely planned on a CZT camera with a low-dose protocol (120 MBq of Sestamibi for stress and 360 MBq at rest for 75 kg body weight), while targeting the recording of only 500 myocardial kcounts in order to limit the recording times (<10 minutes for stress, <4 minutes for rest)...
September 27, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27671493/prognosis-of-stress-only-spect-myocardial-perfusion-imaging-with-prone-imaging
#20
Ariel Gutstein, Tamir Bental, Ajejandro Solodky, Israel Mats, Nili Zafrir
BACKGROUND: Stress-only single-photon emission computed tomography myocardial perfusion imaging (SO SPECT MPI) is associated with similarly benign prognosis as stress-rest SPECT MPI. However, previous studies have used attenuation correction rather than prone imaging to increase the rate of SO studies. OBJECTIVES: To assess the prognosis of SO SPECT MPI performed with prone imaging. METHODS: We performed a retrospective cohort analysis of all patients who underwent a Tc-99m gated SPECT MPI over a 58-month period...
September 26, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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