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https://www.readbyqxmd.com/read/29925107/high-intensity-interval-training-in-different-exercise-modes-lessons-from-time-to-exhaustion
#1
Ana Catarina Sousa, Ricardo J Fernandes, Joao Paulo Vilas Boas, Pedro Figueiredo
To provide information for high-intensity interval training (HIIT) load, we compared the temporal variables of VO2 response at, and after, a time sustained at the exercise intensity corresponding to VO2max (Tlim) in different exercise modes. Forty-five trained male swimmers (11), rowers (13), runners (10) and cyclists (11) completed an incremental protocol to determine the velocity (vVO2max ) or power (wVO2max ) at VO2max and a square wave exercise from rest to 100% of vVO2max /wVO2max . The temporal variables of VO2 response were examined using a breath-by-breath gas analyzer...
June 20, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29925106/the-effect-of-increasing-jump-steps-on-stance-leg-joint-kinetics-in-bounding
#2
Yasushi Kariyama, Hiroaki Hobara, Koji Zushi
Jump distance per step in bounding exercises from the standing position increases with increasing number of steps. We examined the hypothesis that the joint kinetic variables of the stance leg would also increase accordingly. Eleven male athletes (sprinters and jumpers) performed bounding exercise, starting from the double-leg standing posture, and covered the longest distance possible by performing a series of seven forward alternating single-leg jumps. Kinematic and kinetic data were calculated using the data by a motion capture system and force platforms...
June 20, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29925105/developmental-changes-in-isometric-strength-longitudinal-study-in-adolescent-soccer-players
#3
Joao P Duarte, João Valente-Dos-Santos, Manuel J Coelho-E-Silva, R M Malina, Dieter Deprez, Renaat Philippaerts, Matthieu Lenoir, Roel Vaeyens
This study aimed to examine longitudinal changes in isometric strength of the knee extensors (ImKE) and knee flexors (ImKF) at 30° and 60°. The sample was composed of 67 players aged 11.0-13.9 years at baseline over five years. Stature, body mass, skinfolds, and isometric strength (ImKE30°, ImKF30°, ImKE60° and ImKF60°) were measured. Fat mass and fat-free mass (FFM) were derived from skinfolds. Skeletal age was obtained using TW2 RUS. Multilevel random effects regression analyses extracted developmental polynomial models...
June 20, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29925092/bilateral-radial-agenesis-in-a-cat-treated-with-bilateral-ulnocarpal-arthrodesis
#4
Alla Bezhentseva, Harpreet Singh, Randy J Boudrieau
OBJECTIVE:  This article describes corrective antebrachiocarpal re-alignment and arthrodesis for bilateral radial hemimelia (radial agenesis) in an 8-month-old domestic short-haired cat. METHODS:  Bilateral forelimb deformity of ulnocarpal varus with complete luxation and rotation of the antebrachiocarpal joint spaces, and joint contracture, was observed. Several carpal bones and metacarpal bones I and II and their associated phalanges were absent. Abnormal ambulation and weight bearing on the dorsolateral part of the manus were present...
June 20, 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29925090/erratum-to-a-double-blind-randomized-placebo-controlled-trial-of-17-alpha-hydroxyprogesterone-caproate-in-the-management-of-preterm-premature-rupture-of-membranes
#5
Elizabeth S Langen, Anita Sit, Katie Sherwin, Deirdre J Lyell, Yair J Blumenfeld, Yasser Y El-Sayed
No abstract text is available yet for this article.
June 20, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29925086/participant-perspectives-of-a-6-month-telephone-based-lifestyle-coaching-program
#6
Bronwyn McGill, Blythe J O'Hara, Philayrath Phongsavan
Objectives and importance of study: Low program completion rates can undermine the public health impact of even the most effective program. Participant experiences with lifestyle programs are not well reported, but are important for program improvement and retention. The purpose of this study was to understand participant perceptions of the Get Healthy Information and Coaching Service (GHS), a 6-month telephone-based health coaching program to promote lifestyle change. We were particularly interested in participants' initial expectations, their actual experience and, for those who did not complete the program, what influenced their withdrawal...
June 14, 2018: Public Health Research & Practice
https://www.readbyqxmd.com/read/29925054/influence-of-interspecific-interactions-on-avoidance-response-to-contamination
#7
Daniel C V R Silva, Cristiano V M Araújo, Rodrigo J Marassi, Sheila Cardoso-Silva, Morun B Neto, Gilmar C Silva, Rui Ribeiro, Flávio T Silva, Teresa C B Paiva, Marcelo L M Pompêo
An increasing number of studies have shown the ability of organisms to escape from toxic effects due to contamination, by moving spatially towards less contaminated habitats. However, this issue has been investigated in monospecific scenarios, without considering possible interactions between species during the contamination avoidance process. It is widely known that the spatial distribution of one species can be affected by another one, in different ways. Therefore, the main question addressed in the present study was as follows: Might interspecific interaction between the freshwater fish Danio rerio (zebrafish) and Poecilia reticulata (guppy) change their behavior patterns in terms of avoidance in the presence of a copper gradient? Zebrafish and guppies exposed to a copper gradient were tested for avoidance responses in a free-choice, non-forced, static, multi-compartmented exposure system, using two distinct approaches: (1) monospecific tests, in which only one species was exposed to the copper gradient, at two different population densities; and (2) multispecific tests, in which both species were tested simultaneously...
June 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29925049/anionic-and-cationic-drug-sorption-on-interpolyelectrolyte-complexes
#8
C R M de Lima, D N Gomes, J R de Morais Filho, M R Pereira, J L C Fonseca
Interpolyelectrolyte complexes of chitosan and poly(sodium 4-styrenesulfonate) [NaPSS] were synthesized and obtained in the form of solid particles, with two different sulfonate to aminium molar ratios: 0.7, resulting in particles with positive zeta potential (IPEC+ ), and 1.4, yielding particles with negative zeta potential (IPEC- ). Both particles were characterized as potential drug sorbents using differently charged drugs: sodium cromoglycate (negatively charged), and tetracycline hydrochloride (positively charged)...
June 15, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29925038/milestone-ratings-and-supervisory-role-categorizations-swim-together-but-is-the-water-muddy
#9
Daniel J Schumacher, Kathleen W Bartlett, Sean P Elliott, Catherine Michelson, Tanvi Sharma, Lynn C Garfunkel, Beth King, Alan Schwartz
PURPOSE: This single specialty, multi-institutional study aimed to determine: 1) the association between milestone ratings for individual competencies and average milestone ratings (AMRs) and 2) the association between AMRs and recommended supervisory role categorizations made by individual clinical competency committee (CCC) members. METHODS: During the 2015-16 academic year, CCC members at 14 pediatric residencies reported milestone ratings for 21 competencies and recommended supervisory role categories (may not supervise, may supervise in some settings, may supervise in all settings) for residents they reviewed...
June 17, 2018: Academic Pediatrics
https://www.readbyqxmd.com/read/29925037/tspo-ligand-pk11195-improves-alzheimer-related-outcomes-in-aged-female-3xtg-ad-mice
#10
Amy Christensen, Christian J Pike
Alzheimer's disease (AD) pathogenesis is a multifactorial process that involves numerous pathways within the central nervous system. Thus, interventions that interact with several disease-related pathways may offer an increased opportunity for successful prevention and treatment of AD. Translocator protein 18 kD (TSPO) is a mitochondrial protein that is associated with regulation of many cellular processes including inflammation, steroid synthesis, apoptosis, and mitochondrial respiration. Although TSPO ligands have been shown to be protective in several neurodegenerative paradigms, little work has been done to assess their potential as treatments for AD...
June 17, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29925024/ionomycin-induced-changes-in-membrane-potential-alter-electroporation-outcomes-in-hl-60-cells
#11
Erik J Aiken, Brian G Kilberg, Siyuan Yu, Susan C Hagness, John H Booske
Previous studies have shown greater fluorophore uptake during electroporation on the anode-facing side of the cell than on the cathode-facing side. Based on these observations, we hypothesized that hyperpolarizing a cell before electroporation would decrease the requisite pulsed electric field intensity for electroporation outcomes, thereby yielding a higher probability of reversible electroporation at lower electric field strengths and a higher probability of irreversible electroporation (IRE) at higher electric field strengths...
June 19, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29925020/redox-modulation-of-oligomeric-state-in-proline-utilization-a
#12
David A Korasick, Ashley C Campbell, Shelbi L Christgen, Srinivas Chakravarthy, Tommi A White, Donald F Becker, John J Tanner
Homooligomerization of proline utilization A (PutA) bifunctional flavoenzymes is intimately tied to catalytic function and substrate channeling. PutA from Bradyrhizobium japonicum (BjPutA) is unique among PutAs in that it forms a tetramer in solution. Curiously, a dimeric BjPutA hot spot mutant was previously shown to display wild-type catalytic activity despite lacking the tetrameric structure. These observations raised the question of what is the active oligomeric state of BjPutA. Herein, we investigate the factors that contribute to tetramerization of BjPutA in vitro...
June 19, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29925010/the-cancer-genome-atlas-comprehensive-molecular-characterization-of-renal-cell-carcinoma
#13
Christopher J Ricketts, Aguirre A De Cubas, Huihui Fan, Christof C Smith, Martin Lang, Ed Reznik, Reanne Bowlby, Ewan A Gibb, Rehan Akbani, Rameen Beroukhim, Donald P Bottaro, Toni K Choueiri, Richard A Gibbs, Andrew K Godwin, Scott Haake, A Ari Hakimi, Elizabeth P Henske, James J Hsieh, Thai H Ho, Rupa S Kanchi, Bhavani Krishnan, David J Kwiatkowski, Wembin Lui, Maria J Merino, Gordon B Mills, Jerome Myers, Michael L Nickerson, Victor E Reuter, Laura S Schmidt, C Simon Shelley, Hui Shen, Brian Shuch, Sabina Signoretti, Ramaprasad Srinivasan, Pheroze Tamboli, George Thomas, Benjamin G Vincent, Cathy D Vocke, David A Wheeler, Lixing Yang, William Y Kim, A Gordon Robertson, Paul T Spellman, W Kimryn Rathmell, W Marston Linehan
No abstract text is available yet for this article.
June 19, 2018: Cell Reports
https://www.readbyqxmd.com/read/29924996/salmonella-activation-of-stat3-signaling-by-sara-effector-promotes-intracellular-replication-and-production-of-il-10
#14
Sarah L Jaslow, Kyle D Gibbs, W Florian Fricke, Liuyang Wang, Kelly J Pittman, Mark K Mammel, Joshua T Thaden, Vance G Fowler, Gianna E Hammer, Johanna R Elfenbein, Dennis C Ko
Salmonella enterica is an important foodborne pathogen that uses secreted effector proteins to manipulate host pathways to facilitate survival and dissemination. Different S. enterica serovars cause disease syndromes ranging from gastroenteritis to typhoid fever and vary in their effector repertoire. We leveraged this natural diversity to identify stm2585, here designated sarA (Salmonella anti-inflammatory response activator), as a Salmonella effector that induces production of the anti-inflammatory cytokine IL-10...
June 19, 2018: Cell Reports
https://www.readbyqxmd.com/read/29924995/age-related-decline-in-primary-cd8-t-cell-responses-is-associated-with-the-development-of-senescence-in-virtual-memory-cd8-t-cells
#15
Kylie M Quinn, Annette Fox, Kim L Harland, Brendan E Russ, Jasmine Li, Thi H O Nguyen, Liyen Loh, Moshe Olshanksy, Haroon Naeem, Kirill Tsyganov, Florian Wiede, Rosela Webster, Chantelle Blyth, Xavier Y X Sng, Tony Tiganis, David Powell, Peter C Doherty, Stephen J Turner, Katherine Kedzierska, Nicole L La Gruta
Age-associated decreases in primary CD8+ T cell responses occur, in part, due to direct effects on naive CD8+ T cells to reduce intrinsic functionality, but the precise nature of this defect remains undefined. Aging also causes accumulation of antigen-naive but semi-differentiated "virtual memory" (TVM ) cells, but their contribution to age-related functional decline is unclear. Here, we show that TVM cells are poorly proliferative in aged mice and humans, despite being highly proliferative in young individuals, while conventional naive T cells (TN cells) retain proliferative capacity in both aged mice and humans...
June 19, 2018: Cell Reports
https://www.readbyqxmd.com/read/29924991/selective-brain-distribution-and-distinctive-synaptic-architecture-of-dual-glutamatergic-gabaergic-neurons
#16
David H Root, Shiliang Zhang, David J Barker, Jorge Miranda-Barrientos, Bing Liu, Hui-Ling Wang, Marisela Morales
For decades, it has been thought that glutamate and GABA are released by distinct neurons. However, some mouse neurons innervating the lateral habenula (LHb) co-release glutamate and GABA. Here, we mapped the distribution of neurons throughout the rat brain that co-express vesicular transporters for the accumulation of glutamate (VGluT2) or GABA (VGaT) and for GABA synthesis (GAD). We found concentrated groups of neurons that co-express VGluT2, VGaT, and GAD mRNAs within subdivisions of the ventral tegmental area (VTA), entopeduncular (EPN), and supramammillary (SUM) nuclei...
June 19, 2018: Cell Reports
https://www.readbyqxmd.com/read/29924986/replication-fork-reversal-during-dna-interstrand-crosslink-repair-requires-cmg-unloading
#17
Ravindra Amunugama, Smaranda Willcox, R Alex Wu, Ummi B Abdullah, Afaf H El-Sagheer, Tom Brown, Peter J McHugh, Jack D Griffith, Johannes C Walter
DNA interstrand crosslinks (ICLs) are extremely cytotoxic, but the mechanism of their repair remains incompletely understood. Using Xenopus egg extracts, we previously showed that repair of a cisplatin ICL is triggered when two replication forks converge on the lesion. After CDC45/MCM2-7/GINS (CMG) ubiquitylation and unloading by the p97 segregase, FANCI-FANCD2 promotes DNA incisions by XPF-ERCC1, leading to ICL unhooking. Here, we report that, during this cell-free ICL repair reaction, one of the two converged forks undergoes reversal...
June 19, 2018: Cell Reports
https://www.readbyqxmd.com/read/29924970/defens-in-human-%C3%AE-defensin-5-acts-as-an-unwitting-double-agent-to-promote-shigella-infection
#18
Alison G Murphy, Kevin J Maloy
Shigella pathogenesis has confounded researchers for years because of its narrow host selectivity and extraordinary infectious capability. In this issue of Immunity, Xu et al. (2018) identify a cunning mechanism whereby Shigella hijacks human α-defensin 5 to enhance its adhesion and subsequent invasion.
June 19, 2018: Immunity
https://www.readbyqxmd.com/read/29924957/a-survey-of-canine-respiratory-pathogens-in-new-zealand-dogs
#19
H R Sowman, N J Cave, M Dunowska
AIMS: To determine which of the common canine respiratory pathogens circulate among selected populations of healthy and diseased dogs in New Zealand. METHODS: Coagulated blood samples for serology and oropharyngeal swabs for virology were collected from healthy dogs (n=47) and from dogs with acute respiratory disease (n=49). For diseased dogs a convalescent blood sample was also collected 3-4 weeks later. Oropharyngeal swabs were subjected to virus isolation and tested for canine parainfluenza virus (CPIV), canine adenovirus (CAdV) 2, canine herpesvirus (CHV), canine respiratory coronavirus (CRCoV), canine influenza virus (CIV), canine distemper virus (CDV), Bordetella bronchiseptica, Streptococcus equi subsp...
June 20, 2018: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/29924955/sodium-thiosulfate-for-protection-from-cisplatin-induced-hearing-loss
#20
Penelope R Brock, Rudolf Maibach, Margaret Childs, Kaukab Rajput, Derek Roebuck, Michael J Sullivan, Véronique Laithier, Milind Ronghe, Patrizia Dall'Igna, Eiso Hiyama, Bénédicte Brichard, Jane Skeen, M Elena Mateos, Michael Capra, Arun A Rangaswami, Marc Ansari, Catherine Rechnitzer, Gareth J Veal, Anna Covezzoli, Laurence Brugières, Giorgio Perilongo, Piotr Czauderna, Bruce Morland, Edward A Neuwelt
Background Cisplatin chemotherapy and surgery are effective treatments for children with standard-risk hepatoblastoma but may cause considerable and irreversible hearing loss. This trial compared cisplatin with cisplatin plus delayed administration of sodium thiosulfate, aiming to reduce the incidence and severity of cisplatin-related ototoxic effects without jeopardizing overall and event-free survival. Methods We randomly assigned children older than 1 month and younger than 18 years of age who had standard-risk hepatoblastoma (≤3 involved liver sectors, no metastatic disease, and an alpha-fetoprotein level of >100 ng per milliliter) to receive cisplatin alone (at a dose of 80 mg per square meter of body-surface area, administered over a period of 6 hours) or cisplatin plus sodium thiosulfate (at a dose of 20 g per square meter, administered intravenously over a 15-minute period, 6 hours after the discontinuation of cisplatin) for four preoperative and two postoperative courses...
June 21, 2018: New England Journal of Medicine
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