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https://www.readbyqxmd.com/read/29684945/-it-s-going-to-be-extra-fun-analysis-of-an-atypical-case-of-teen-homicide-as-leisure-behavior
#1
D J Williams, Jolene Vincent
Recently, scholars in literary criminology and leisure sciences have begun to explore the role of broader leisure culture in potentially shaping fantasy development, planning, preparation, and execution in specific cases of expressive homicide. This brief report focuses on an unusual case of expressive homicide, wherein two teen offenders in Idaho collaborated to murder a female classmate as an intentional leisure activity. Prior to the murder, the offenders created a videotape describing how they planned to commit this (and additional) murders...
April 23, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29684937/the-swedish-school-attack-in-trollh%C3%A3-ttan
#2
Åsa Erlandsson, J Reid Meloy
This is a case report of the offender and offense characteristics of a targeted attack on a Swedish school using a sword, with a particular focus upon the offender's history, the relationship between mental disorder and ideology, and whether or not it was an act of terrorism. Findings indicate that the offender had no drug or psychiatric treatment history, but postoffense analysis suggests autism spectrum disorder, depression, and both suicidal ideation and intent. The offender planned and prepared for his attack, and the triggering event appeared to be the loss of a temporary job...
April 23, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29684918/correction-examining-the-construct-and-known-group-validity-of-a-composite-endpoint-for-the-older-persons-and-informal-caregivers-survey-minimum-data-set-topics-mds-a-large-scale-data-sharing-initiative
#3
Cynthia S Hofman, Jennifer E Lutomski, Han Boter, Bianca M Buurman, Anton J M de Craen, Rogier Donders, Marcel G M Olde Rikkert, Peter Makai, René J F Melis
[This corrects the article DOI: 10.1371/journal.pone.0173081.].
2018: PloS One
https://www.readbyqxmd.com/read/29684901/an%C3%A3-lisis-de-costo-de-la-enfermedad-del-tratamiento-las-complicaciones-e-intervenciones-de-la-hipercolesterolemia-en-m%C3%A3-xico-en-2016
#4
German Baeza-Cruz, Gustavo Peniche-Otero, Mónica E Alva-Esqueda, Mariana Naranjo-Muedano, Noé Soria-Suárez, Héctor J Morales-Flores
OBJETIVOS: Describir los costos y el impacto económico de la atención de pacientes diagnosticados con hipercolesterolemia en México en el año 2016. METODOLOGíA: Se desarrolla una evaluación económica del tipo análisis de costo de la enfermedad donde se cuantifican los recursos médicos utilizados para el tratamiento de la hipercolesterolemia así como para sus complicaciones. Los costos de los recursos médicos utilizados son obtenidos de los costos unitarios por nivel de atención del Instituto Mexicano del Seguro Social (IMSS) así como de las licitaciones publicadas en el portal de compras del IMSS...
April 20, 2018: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29684900/generation-of-the-human-induced-pluripotent-stem-cell-hipsc-line-psmi003-a-from-a-patient-affected-by-an-autosomal-recessive-form-of-long-qt-syndrome-type-1
#5
Manuela Mura, Monia Ginevrino, Rita Zappatore, Federica Pisano, Marina Boni, Silvia Castelletti, Lia Crotti, Enza Maria Valente, Peter J Schwartz, Massimiliano Gnecchi
We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a 51years old female patient homozygous for the mutation c.535 G>A p.G179S on the KCNQ1 gene, causing a severe form of autosomal recessive Long QT Syndrome type 1 (AR-LQT1), not associated with deafness. The hiPSCs, generated using four retroviruses each encoding for a reprogramming factor OCT4, SOX2, KLF4, cMYC, are pluripotent and can differentiate into spontaneously beating cardiomyocytes (hiPSC-CMs).
April 6, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29684897/reproductive-and-developmental-changes-in-tree-swallows-tachycineta-bicolor-are-influenced-by-multiple-stressors-including-polycyclic-aromatic-compounds-in-the-athabasca-oil-sands
#6
K J Fernie, S C Marteinson, C Soos, D Chen, L Cruz-Martinez, J E G Smits
Mining in the Athabasca Oil Sands Region (AOSR) has contributed extensively to increased exposure of wildlife to naturally occurring polycyclic aromatic compounds (PACs), yet little is known about the toxicity of PACs to wildlife in this region. We identified reproductive and developmental changes in tree swallows (Tachycineta bicolor) breeding in close proximity to mining-related activities in the AOSR, and determined these changes in relation to the birds' exposure and accumulation of 41 PACs (parent-, alkylated-PAHs), dibenzothiophenes (DBTs; previously published), diet (carbon (δ13 C), nitrogen (δ15 N)), volatile organic compounds, and weather variables...
April 20, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29684891/considering-high-alcohol-and-violence-neighborhood-context-using-daily-diaries-and-gps-a-pilot-study-among-people-living-with-hiv
#7
Katherine P Theall, Erica Felker-Kantor, Maeve Wallace, Xiao Zhang, Christopher N Morrison, Douglas J Wiebe
Our understanding of how community-level context impacts care of persons living with HIV (PLWH), including antiretroviral therapy (ART) adherence and retention in care, is limited. The objective of this study was to characterize the activity spaces of PLWH from an urban area in Southeastern U.S., where the epidemic is among the nation's highest, and to examine how such activity spaces are associated with daily mood and health behaviors. In this small, pilot study, 11 participants were tracked with a global positioning system (GPS)-enabled application on their smartphones for 2 weeks...
April 10, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29684886/the-effects-of-three-quarter-and-full-length-foot-orthoses-on-knee-mechanics-in-healthy-subjects-and-patellofemoral-pain-patients-when-walking-and-descending-stairs
#8
J Burston, J Richards, J Selfe
BACKGROUND: An increased load of the patellofemoral joint is often attributed to foot function in patients with patellofemoral pain. Foot orthoses are commonly prescribed for this condition; however the mechanisms by which they work are poorly understood. The aim of this study was to investigate the kinematics and kinetics of the knee between patellofemoral pain patients and a group of healthy subjects when using a standardised foot orthosis prescription during walking and step descent...
April 17, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29684880/exposure-to-air-pollution-interacts-with-obesogenic-nutrition-to-induce-tissue-specific-response-patterns
#9
Michal Pardo, Yael Kuperman, Liron Levin, Assaf Rudich, Yulia Haim, James J Schauer, Alon Chen, Yinon Rudich
Obesity and exposure to particular matter (PM) have become two leading global threats to public health. However, the exact mechanisms and tissue-specificity of their health effects are largely unknown. Here we investigate whether a metabolic challenge (early nutritional obesity) synergistically interacts with an environmental challenge (PM exposure) to alter genes representing key response pathways, in a tissue-specific manner. Mice subjected to 7 weeks obesogenic nutrition were exposed every other day during the final week and a half to aqueous extracts of PM collected in the city of London (UK)...
April 20, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29684874/treatment-of-an-azo-dye-effluent-by-peroxi-coagulation-and-its-comparison-to-traditional-electrochemical-advanced-processes
#10
Edilson do Vale-Júnior, Djalma R da Silva, Ana S Fajardo, Carlos A Martínez-Huitle
Peroxi-coagulation (PC) is an interesting new process that has not been widely studied in the literature. This work presents the application of this technology to treat an azo dye synthetic effluent, studying the effect of different parameters including initial pH, current density (j), initial dye concentration and supporting electrolyte. The two former variables significantly affected the colour removal of the wastewater, followed by the initial dye concentration and the kind of electrolyte, in a lesser extent...
April 5, 2018: Chemosphere
https://www.readbyqxmd.com/read/29684840/predicting-pork-loin-intramuscular-fat-using-computer-vision-system
#11
J-H Liu, X Sun, J M Young, L A Bachmeier, D J Newman
The objective of this study was to investigate the ability of computer vision system to predict pork intramuscular fat percentage (IMF%). Center-cut loin samples (n = 85) were trimmed of subcutaneous fat and connective tissue. Images were acquired and pixels were segregated to estimate image IMF% and 18 image color features for each image. Subjective IMF% was determined by a trained grader. Ether extract IMF% was calculated using ether extract method. Image color features and image IMF% were used as predictors for stepwise regression and support vector machine models...
March 26, 2018: Meat Science
https://www.readbyqxmd.com/read/29684812/quantitative-evaluation-of-the-matrix-effect-in-bioanalytical-methods-based-on-lc-ms-a-comparison-of-two-approaches
#12
Piotr J Rudzki, Elżbieta Gniazdowska, Katarzyna Buś-Kwaśnik
Liquid chromatography coupled to mass spectrometry (LC-MS) is a powerful tool for studying pharmacokinetics and toxicokinetics. Reliable bioanalysis requires the characterization of the matrix effect, i.e. influence of the endogenous or exogenous compounds on the analyte signal intensity. We have compared two methods for the quantitation of matrix effect. The CVs(%) of internal standard normalized matrix factors recommended by the European Medicines Agency were evaluated against internal standard normalized relative matrix effects derived from Matuszewski et al...
April 6, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29684811/behavioral-semiochemical-and-androgen-responses-by-male-giant-pandas-to-the-olfactory-sexual-receptivity-cues-of-females
#13
Abbey E Wilson, Darrell L Sparks, Katrina K Knott, Andrew J Kouba, Scott Willard, Ashli Brown
Male giant pandas identify female sexual receptivity through the detection of olfactory cues in estrous urine. However, it is yet unknown which specific days of the female estrous cycle may provoke male sexual-social responses and a physiological readiness to mate. We hypothesized that female urine from specific days of the estrous cycle will be positively associated with specific changes in male behaviors, urinary semiochemical production, and steroidogenic activity. Experimental simultaneous choice trials were conducted in captivity with four male giant pandas during the spring breeding season and during fall...
April 11, 2018: Theriogenology
https://www.readbyqxmd.com/read/29684810/associations-between-dairy-cow-inter-service-interval-and-probability-of-conception
#14
J G Remnant, M J Green, J N Huxley, C D Hudson
Recent research has indicated that the interval between inseminations in modern dairy cattle is often longer than the commonly accepted cycle length of 18-24 days. This study analysed 257,396 inseminations in 75,745 cows from 312 herds in England and Wales. The interval between subsequent inseminations in the same cow in the same lactation (inter-service interval, ISI) were calculated and inseminations categorised as successful or unsuccessful depending on whether there was a corresponding calving event. Conception risk was calculated for each individual ISI between 16 and 28 days...
April 11, 2018: Theriogenology
https://www.readbyqxmd.com/read/29684808/tissue-interactions-and-estrogenic-response-during-human-female-fetal-reproductive-tract-development
#15
Gerald R Cunha, Takeshi Kurita, Mei Cao, Joel Shen, Paul S Cooke, Stanley J Robboy, Laurence S Baskin
The role of tissue interactions was explored to determine whether epithelial differentiation within the developing human reproductive tract is induced and specified by mesenchyme in tissue recombinants composed of mouse vaginal mesenchyme + human uterine tubal epithelium (mVgM+hTubE). The tissue recombinants were grown in DES-treated ovariectomized athymic mice. After 2-4 weeks of in vivo growth, several vaginal specific features were expressed in the human tubal epithelium. The mesenchyme-induced effects included morphological change as well as expression of several immunohistochemical markers...
April 18, 2018: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/29684801/evaluation-of-racial-disparities-in-pediatric-optic-pathway-glioma-incidence-results-from-the-surveillance-epidemiology-and-end-results-program-2000-2014
#16
Erin C Peckham-Gregory, Roberto E Montenegro, David A Stevenson, David H Viskochil, Michael E Scheurer, Philip J Lupo, Joshua D Schiffman
BACKGROUND: Racial predilection to pediatric cancer exists; however optic pathway glioma (OPG) risk differences by race/ethnicity are undefined. We estimated differences in OPG incidence across racial/ethnic groups in a multi-state cancer surveillance registry in the United States. METHODS: OPG data were obtained from the Surveillance, Epidemiology, and End Results (SEER-18) Program, 2000-2014. Race/ethnicity was categorized as: White; Black; Asian; Other; and Latino/a ("Spanish-Hispanic-Latino")...
April 20, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29684795/screening-for-postpartum-anxiety-a-quality-improvement-project-to-promote-the-screening-of-women-suffering-in-silence
#17
Sarah Toler, Susan Stapleton, Kim Kertsburg, Tiffany J Callahan, Marie Hastings-Tolsma
BACKGROUND: Postpartum anxiety is a mental health problem that has largely been ignored by maternity care providers despite an estimated incidence as high as 28.9%. Though postpartum anxiety may or may not be accompanied by depression, and while screening for postpartum depression has become more common place, postpartum anxiety is often not assessed or addressed. PURPOSE: The purpose of this pilot quality improvement project was to implement a screening, treatment and referral program for postpartum anxiety in the birth centre environment...
April 3, 2018: Midwifery
https://www.readbyqxmd.com/read/29684792/global-effects-of-ddx3-inhibition-on-cell-cycle-regulation-identified-by-a-combined-phosphoproteomics-and-single-cell-tracking-approach
#18
Marise R Heerma van Voss, Kai Kammers, Farhad Vesuna, Justin Brilliant, Yehudit Bergman, Saritha Tantravedi, Xinyan Wu, Robert N Cole, Andrew Holland, Paul J van Diest, Venu Raman
DDX3 is an RNA helicase with oncogenic properties. The small molecule inhibitor RK-33 is designed to fit into the ATP binding cleft of DDX3 and hereby block its activity. RK-33 has shown potent activity in preclinical cancer models. However, the mechanism behind the antineoplastic activity of RK-33 remains largely unknown. In this study we used a dual phosphoproteomic and single cell tracking approach to evaluate the effect of RK-33 on cancer cells. MDA-MB-435 cells were treated for 24 hours with RK-33 or vehicle control...
April 20, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29684790/is-there-evidence-to-use-kinematic-kinetic-measures-clinically-in-low-back-pain-patients-a-systematic-review
#19
REVIEW
Enrica Papi, Anthony M J Bull, Alison H McGregor
BACKGROUND: Currently, there is a widespread reliance on self-reported questionnaires to assess low back pain patients. However, it has been suggested that objective measures of low back pain patients' functional status should be used to aid clinical assessment. The aim of this study is to systematically review which kinematic /kinetic parameters have been used to assess low back pain patients against healthy controls and to propose clinical kinematic/kinetic measures. METHODS: PubMed, Embase and Scopus databases were searched for relevant studies...
April 11, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29684789/bipedal-hopping-timed-to-a-metronome-to-detect-impairments-in-anticipatory-motor-control-in-people-with-mild-multiple-sclerosis
#20
Megan C Kirkland, Alice Chen, Matthew B Downer, Brett J Holloway, Elizabeth M Wallack, Evan J Lockyer, Natasha C M Buckle, Courtney L Abbott, Michelle Ploughman
BACKGROUND: People with mild multiple sclerosis (MS) often report subtle deficits in balance and cognition but display no measurable impairment on clinical assessments. We examined whether hopping to a metronome beat had the potential to detect anticipatory motor control deficits among people with mild MS (Expanded Disability Status Scale ≤ 3.5). METHODS: Participants with MS (n = 13), matched controls (n = 9), and elderly subjects (n = 13) completed tests of cognition (Montreal Cognitive Assessment (MoCA)) and motor performance (Timed 25 Foot Walk Test (T25FWT))...
April 13, 2018: Clinical Biomechanics
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