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Finite element analysis heart valves

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https://www.readbyqxmd.com/read/27876370/non-linear-rotation-free-shell-finite-element-models-for-aortic-heart-valves
#1
Anvar Gilmanov, Henryk Stolarski, Fotis Sotiropoulos
Hyperelastic material models have been incorporated in the rotation-free, large deformation, shell finite element (FE) formulation of (Stolarski et al., 2013) and applied to dynamic simulations of aortic heart valve. Two models used in the past in analysis of such problem i.e. the Saint-Venant and May-Newmann-Yin (MNY) material models have been considered and compared. Uniaxial tests for those constitutive equations were performed to verify the formulation and implementation of the models. The issue of leaflets interactions during the closing of the heart valve at the end of systole is considered...
November 14, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27182096/biomechanics-simulations-using-cubic-hermite-meshes-with-extraordinary-nodes-for-isogeometric-cardiac-modeling
#2
Adarsh Krishnamurthy, Matthew J Gonzales, Gregory Sturgeon, W Paul Segars, Andrew D McCulloch
Cubic Hermite hexahedral finite element meshes have some well-known advantages over linear tetrahedral finite element meshes in biomechanical and anatomic modeling using isogeometric analysis. These include faster convergence rates as well as the ability to easily model rule-based anatomic features such as cardiac fiber directions. However, it is not possible to create closed complex objects with only regular nodes; these objects require the presence of extraordinary nodes (nodes with 3 or >= 5 adjacent elements in 2D) in the mesh...
March 2016: Computer Aided Geometric Design
https://www.readbyqxmd.com/read/27173827/characterization-of-three-dimensional-anisotropic-heart-valve-tissue-mechanical-properties-using-inverse-finite-element-analysis
#3
Mostafa Abbasi, Mohammed S Barakat, Koohyar Vahidkhah, Ali N Azadani
Computational modeling has an important role in design and assessment of medical devices. In computational simulations, considering accurate constitutive models is of the utmost importance to capture mechanical response of soft tissue and biomedical materials under physiological loading conditions. Lack of comprehensive three-dimensional constitutive models for soft tissue limits the effectiveness of computational modeling in research and development of medical devices. The aim of this study was to use inverse finite element (FE) analysis to determine three-dimensional mechanical properties of bovine pericardial leaflets of a surgical bioprosthesis under dynamic loading condition...
September 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/26864541/a-parametric-computational-study-of-the-impact-of-non-circular-configurations-on-bioprosthetic-heart-valve-leaflet-deformations-and-stresses-possible-implications-for-transcatheter-heart-valves
#4
Nandini Duraiswamy, Jason D Weaver, Yasamin Ekrami, Stephen M Retta, Changfu Wu
Although generally manufactured as circular devices with symmetric leaflets, transcatheter heart valves can become non-circular post-implantation, the impact of which on the long-term durability of the device is unclear. We investigated the effects of five non-circular (EllipMajor, EllipMinor, D-Shape, TriVertex, TriSides) annular configurations on valve leaflet stresses and valve leaflet deformations through finite element analysis. The highest in-plane principal stresses and strains were observed under an elliptical configuration with an aspect ratio of 1...
June 2016: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/26592436/material-modeling-of-cardiac-valve-tissue-experiments-constitutive-analysis-and-numerical-investigation
#5
Stefanie Heyden, Andreas Nagler, Cristóbal Bertoglio, Jonas Biehler, Michael W Gee, Wolfgang A Wall, Michael Ortiz
A key element of the cardiac cycle of the human heart is the opening and closing of the four valves. However, the material properties of the leaflet tissues, which fundamentally contribute to determine the mechanical response of the valves, are still an open field of research. The main contribution of the present study is to provide a complete experimental data set for porcine heart valve samples spanning all valve and leaflet types under tensile loading. The tests show a fair degree of reproducibility and are clearly indicative of a number of fundamental tissue properties, including a progressively stiffening response with increasing elongation...
December 16, 2015: Journal of Biomechanics
https://www.readbyqxmd.com/read/26537200/age-dependent-changes-of-stress-and-strain-in-the-human-heart-valve-and-their-relation-with-collagen-remodeling
#6
P J A Oomen, S Loerakker, D van Geemen, J Neggers, M-J T H Goumans, A J van den Bogaerdt, A J J C Bogers, C V C Bouten, F P T Baaijens
UNLABELLED: In order to create tissue-engineered heart valves with long-term functionality, it is essential to fully understand collagen remodeling during neo-tissue formation. Collagen remodeling is thought to maintain mechanical tissue homeostasis. Yet, the driving factor of collagen remodeling remains unidentified. In this study, we determined the collagen architecture and the geometric and mechanical properties of human native semilunar heart valves of fetal to adult age using confocal microscopy, micro-indentation and inverse finite element analysis...
January 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/26416720/the-impact-of-fluid-inertia-on-in-vivo-estimation-of-mitral-valve-leaflet-constitutive-properties-and-mechanics
#7
David L Bark, Lakshmi P Dasi
We examine the influence of the added mass effect (fluid inertia) on mitral valve leaflet stress during isovolumetric phases. To study this effect, oscillating flow is applied to a flexible membrane at various frequencies to control inertia. Resulting membrane strain is calculated through a three-dimensional reconstruction of markers from stereo images. To investigate the effect in vivo, the analysis is repeated on a published dataset for an ovine mitral valve (Journal of Biomechanics 42(16): 2697-2701). The membrane experiment demonstrates that the relationship between pressure and strain must be corrected with a fluid inertia term if the ratio of inertia to pressure differential approaches 1...
May 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/26378868/development-of-a-transcatheter-tricuspid-valve-prosthesis-through-steps-of-iterative-optimization-and-finite-element-analysis
#8
Desiree Pott, Maximilian Kütting, Zhaoyang Zhong, Andrea Amerini, Jan Spillner, Rüdiger Autschbach, Ulrich Steinseifer
The development of a transcatheter tricuspid valve prosthesis for the treatment of tricuspid regurgitation (TR) is presented. The design process involves an iterative development method based on computed tomography data and different steps of finite element analysis (FEA). The enhanced design consists of two self-expandable stents, one is placed inside the superior vena cava (SVC) for primary device anchoring, the second lies inside the tricuspid valve annulus (TVA). Both stents are connected by flexible connecting struts (CS) to anchor the TVA-stent in the orthotopic position...
October 2015: Artificial Organs
https://www.readbyqxmd.com/read/25764717/-influence-of-pivot-distance-on-the-performance-of-a-mechanic-heart-valve
#9
Yong Zhang, Liangliang Wu, Nan Huang
Based on the analysis of the influence of the valve pivot distance on the performance of mechanical heart valve (MHV), such as the valve opening and closing features, flow field characteristics and the valve assembly properties, value constraints of the valve pivot distance were established, and the reasonable valve was obtained by means of the finite element method. It can be shown that the central flow characteristics of the valve could be enhanced with the increasing of the ratio of pivot distance to valve inner diameter, but the plastic deformation of the ring could be liable to occur in the MHV assembly process...
October 2014: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/25469460/mitral-valve-annuloplasty-rings-review-of-literature-and-comparison-of-functional-outcome-and-ventricular-dimensions
#10
REVIEW
Arash Khamooshian, Marc P Buijsrogge, Frederiek de Heer, Paul F Gründeman
In the past decades, more than 40 mitral valve annuloplasty rings of various shapes and consistency were marketed for mitral regurgitation (MR), although the effect of ring type on clinical outcome remains unclear. Our objective was to review the literature and apply a simplification method to make rings of different shapes and rigidity more comparable. We studied relevant literature from MEDLINE and EMBASE databases related to clinical studies as well as animal and finite element models. Annuloplasty rings were clustered into 3 groups as follows: rigid (R), flexible (F), and semirigid (S)...
November 2014: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/25252695/structural-analysis-of-a-stented-pericardial-heart-valve-with-leaflets-mounted-externally
#11
Andrea Avanzini, Davide Battini
Our aim was to understand the structural and functional behaviour of a pericardial heart valve with biological leaflets attached externally to a stent. To our knowledge, there is little if any literature concerning these kinds of bioprosthetic heart valves, while there is more concerning bioprosthetic heart valves with leaflets mounted internally. We studied the problem using a finite element approach considering leaflets and stent interaction, the influence of leaflet anisotropy and stent stiffness, by comparing quasi-static and dynamic loadings...
October 2014: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/24746106/design-considerations-and-quantitative-assessment-for-the-development-of-percutaneous-mitral-valve-stent
#12
Gideon Praveen Kumar, Fangsen Cui, Hui Qun Phang, Boyang Su, Hwa Liang Leo, Jimmy Kim Fatt Hon
Percutaneous heart valve replacement is gaining popularity, as more positive reports of satisfactory early clinical experiences are published. However this technique is mostly used for the replacement of pulmonary and aortic valves and less often for the repair and replacement of atrioventricular valves mainly due to their anatomical complexity. While the challenges posed by the complexity of the mitral annulus anatomy cannot be mitigated, it is possible to design mitral stents that could offer good anchorage and support to the valve prosthesis...
July 2014: Medical Engineering & Physics
https://www.readbyqxmd.com/read/23477432/virtualisation-of-stress-distribution-in-heart-valve-tissue
#13
Siyao Huang, Hsiao-Ying Shadow Huang
This study presents an image-based finite element analysis incorporating histological photomicrographs of heart valve tissues. We report stress fields inside heart valve tissues, where heterogeneously distributed collagen fibres are responsible for transmitting forces into cells. Linear isotropic and anisotropic tissue material property models are incorporated to quantify the overall stress distributions in heart valve tissues. By establishing an effective predictive method with new computational tools and by performing virtual experiments on the heart valve tissue photomicrographs, we clarify how stresses are transferred from matrix to cell...
November 2014: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/23445066/in-vitro-evaluation-of-a-novel-hemodynamically-optimized-trileaflet-polymeric-prosthetic-heart-valve
#14
Thomas E Claiborne, Jawaad Sheriff, Maximilian Kuetting, Ulrich Steinseifer, Marvin J Slepian, Danny Bluestein
Calcific aortic valve disease is the most common and life threatening form of valvular heart disease, characterized by stenosis and regurgitation, which is currently treated at the symptomatic end-stages via open-heart surgical replacement of the diseased valve with, typically, either a xenograft tissue valve or a pyrolytic carbon mechanical heart valve. These options offer the clinician a choice between structural valve deterioration and chronic anticoagulant therapy, respectively, effectively replacing one disease with another...
February 2013: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/23372624/simulation-based-design-and-evaluation-of-a-transcatheter-mitral-heart-valve-frame
#15
Melissa Young, Ahmet Erdemir, Samantha Stucke, Ryan Klatte, Brian Davis, Jose L Navia
In certain populations, open heart surgery to replace a diseased mitral valve is not an option, leaving percutaneous delivery a viable alternative. However, a surgical transcatheter based delivery of a metallic support frame incorporating a tissue derived valve puts considerable constraints on device specifications. Expansion to a large diameter from the catheter diameter without mechanical fracture involves advanced device design and appropriate material processing and selection. In this study, a new frame concept is presented with a desirable feature that incorporates wings that protrude during expansion to establish adequate fixation...
September 2012: Journal of Medical Devices
https://www.readbyqxmd.com/read/23367453/virtual-experiments-of-heart-valve-tissues
#16
Siyao Huang, Hsiao-Ying S Huang
The heart valve tissue mainly contains collagen fibers and valve interstitial cells (VICs) and constantly experiences different stress states during cardiac cycles. Due to the anisotropic architecture of collagen fibers and highly inhomogeneous cell population, the mechanical behavior of the heart valve becomes more complicated. It is known that external mechanical stimuli can lead to extracellular matrix (ECM) remodeling, cellular mechanotransduction, cell migration, and collagen synthesis; however, the mechanism of matrix-to-cell stress transfer remains unclear...
2012: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/23294966/optimal-elastomeric-scaffold-leaflet-shape-for-pulmonary-heart-valve-leaflet-replacement
#17
Rong Fan, Ahmed S Bayoumi, Peter Chen, Christopher M Hobson, William R Wagner, John E Mayer, Michael S Sacks
Surgical replacement of the pulmonary valve (PV) is a common treatment option for congenital pulmonary valve defects. Engineered tissue approaches to develop novel PV replacements are intrinsically complex, and will require methodical approaches for their development. Single leaflet replacement utilizing an ovine model is an attractive approach in that candidate materials can be evaluated under valve level stresses in blood contact without the confounding effects of a particular valve design. In the present study an approach for optimal leaflet shape design based on finite element (FE) simulation of a mechanically anisotropic, elastomeric scaffold for PV replacement is presented...
February 22, 2013: Journal of Biomechanics
https://www.readbyqxmd.com/read/23263365/mechanics-of-the-mitral-valve-a-critical-review-an-in-vivo-parameter-identification-and-the-effect-of-prestrain
#18
REVIEW
Manuel K Rausch, Nele Famaey, Tyler O'Brien Shultz, Wolfgang Bothe, D Craig Miller, Ellen Kuhl
Alterations in mitral valve mechanics are classical indicators of valvular heart disease, such as mitral valve prolapse, mitral regurgitation, and mitral stenosis. Computational modeling is a powerful technique to quantify these alterations, to explore mitral valve physiology and pathology, and to classify the impact of novel treatment strategies. The selection of the appropriate constitutive model and the choice of its material parameters are paramount to the success of these models. However, the in vivo parameters values for these models are unknown...
October 2013: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/23174421/toward-patient-specific-simulations-of-cardiac-valves-state-of-the-art-and-future-directions
#19
REVIEW
Emiliano Votta, Trung Bao Le, Marco Stevanella, Laura Fusini, Enrico G Caiani, Alberto Redaelli, Fotis Sotiropoulos
Recent computational methods enabling patient-specific simulations of native and prosthetic heart valves are reviewed. Emphasis is placed on two critical components of such methods: (1) anatomically realistic finite element models for simulating the structural dynamics of heart valves; and (2) fluid structure interaction methods for simulating the performance of heart valves in a patient-specific beating left ventricle. It is shown that the significant progress achieved in both fronts paves the way toward clinically relevant computational models that can simulate the performance of a range of heart valves, native and prosthetic, in a patient-specific left heart environment...
January 18, 2013: Journal of Biomechanics
https://www.readbyqxmd.com/read/23036945/on-the-biomechanical-role-of-glycosaminoglycans-in-the-aortic-heart-valve-leaflet
#20
Chad E Eckert, Rong Fan, Brandon Mikulis, Mathew Barron, Christopher A Carruthers, Vincent M Friebe, Naren R Vyavahare, Michael S Sacks
While the role of collagen and elastin fibrous components in heart valve valvular biomechanics has been extensively investigated, the biomechanical role of the glycosaminoglycan (GAG) gelatinous-like material phase remains unclear. In the present study, we investigated the biomechanical role of GAGs in porcine aortic valve (AV) leaflets under tension utilizing enzymatic removal. Tissue specimens were removed from the belly region of porcine AVs and subsequently treated with either an enzyme solution for GAG removal or a control (buffer with no enzyme) solution...
January 2013: Acta Biomaterialia
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