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https://www.readbyqxmd.com/read/29027633/multi-modality-imaging-in-the-evaluation-and-treatment-of-mitral-regurgitation
#1
REVIEW
Marc-André Bouchard, Claudia Côté-Laroche, Jonathan Beaudoin
Mitral regurgitation (MR) is frequent and associated with increased mortality and morbidity when severe. It may be caused by intrinsic valvular disease (primary MR) or ventricular deformation (secondary MR). Imaging has a critical role to document the severity, mechanism, and impact of MR on heart function as selected patients with MR may benefit from surgery whereas other will not. In patients planned for a surgical intervention, imaging is also important to select candidates for mitral valve (MV) repair over replacement and to predict surgical success...
October 13, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29027095/multimodality-imaging-of-pericardial-diseases
#2
REVIEW
Mouaz H Al-Mallah, Fatimah Almasoudi, Mohamed Ebid, Amjad M Ahmed, Abdelrahman Jamiel
Pericardial diseases have changed their epidemiology in the past few years. With the aging population and decreasing incidence of communicable diseases, the causes of pericardial diseases have significantly changed from infectious and malignant to postradiation and cardiac surgery causes. Despite that, pericardial diseases remain difficult to diagnose. The accurate and timely diagnosis of these diseases is essential to avoid the late sequela of pericardial constriction and pericardial cirrhosis. Echocardiography remains the first test of choice for the assessment of patients with suspected pericardial diseases...
October 12, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29023143/changes-of-emphysema-parameters-over-the-respiratory-cycle-during-free-breathing-preliminary-results-using-respiratory-gated-4d-ct
#3
Julia Ley-Zaporozhan, Sebastian Ley, Jürgen Mews, Oliver Weinheimer, Sonja Kandel, Patrik Rogalla
The purpose of this research was to evaluate respiratory gated CT of the lung in patients with COPD for analysis of parenchymal characteristics who were potential candidates for volume reduction surgery. Eleven patients with clinically known emphysematous disease underwent a respiratory gated, free-breathing 64-multislice-CT (Aquilion 64, Toshiba). Retrospective image reconstruction was performed similar to cardiac CT at every 10% of the respiratory loop, resulting in 10 complete volumetric datasets at 10 equidistant time points...
October 12, 2017: COPD
https://www.readbyqxmd.com/read/29018408/levels-of-hepatic-activating-transcription-factor-6-and-caspase-3-are-downregulated-in-mice-after-excessive-training
#4
Ana P Pinto, Alisson L da Rocha, Luciana da C Oliveira, Gustavo P Morais, Larissa G de Vicente, Dennys E Cintra, José R Pauli, Leandro P Moura, Eduardo R Ropelle, Adelino S R da Silva
Recently, we demonstrated that different running overtraining (OT) protocols with the same external load, but performed downhill (OTR/down), uphill (OTR/up), and without inclination (OTR), led to hepatic fat accumulation. As the disruption of endoplasmic reticulum (ER) homeostasis is linked to animal models of fatty liver disease, we investigated the effects of these OT models on the proteins related to ER stress (i.e., BiP, inositol-requiring enzyme 1, protein kinase RNA-like endoplasmic reticulum kinase, eIF2alpha, ATF6beta, and glucose-regulated protein 94) and apoptosis (C/EBP-homologous protein, Caspase-3, 4, and 12, Bax, and tumor necrosis factor receptor-associated factor 2) in livers of C57BL/6 mice...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29018009/paediatric-case-of-ductal-origin-of-right-pulmonary-artery-presenting-with-exertional-dyspnoea-and-mimicking-asthma-and-primary-ciliary-dyskinesia
#5
Malvika Sagar, Anderson S Marshall, Cody W Clary, Athar M Qureshi
Ductal origin of pulmonary artery is a rare anomaly that is frequently misdiagnosed. Patients may present with exertional dyspnoea, recurrent respiratory infections and pulmonary hypertension. The presence of pulmonary hypertension can adversely affect clinical outcome in these patients; hence, early identification and intervention is the key to improve survival. A case of a 3-year-old child presenting with exertional dyspnoea is presented in this report. Chest radiograph revealed right-sided pulmonary hypoplasia and mediastinal shift to the right...
October 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29017648/-neurological-prognostic-value-of-gray-white-matter-ratio-in-patients-after-respiratory-and-cardiac-arrest
#6
Hengjun Liu, Peng Xu, Fei He, Yao Liu, Jun Wang
OBJECTIVE: To evaluate the role of gray-white-matter ratio (GWR) on neurological outcome in patients with coma after cardiopulmonary resuscitation (CPR) post-respiratory and cardiac arrest (CA). METHODS: Respiratory and CA patients with restoration of spontaneous circulation (ROSC) and coma after CPR admitted to Nanjing Drum Tower Hospital Clinical Medical College of Nanjing Medical University from February 2013 to June 2016 were enrolled. All patients were subjected to target temperature management (TTM) after CPR, and received cranial CT within 5 days after ROSC...
October 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29017220/-bronchitis-plastica-acute-dyspnea-and-branching-airway-casts
#7
P Wischmann, S Keymel, M Kelm, S Krüger
A 65 year old female presented to the emergency department with dyspnea and progressive cough with very viscous elongated secretion plugs. She suffered from multiple cardiac comorbidities and chronic heart failure. The CT scan of the thorax demonstrated extensive pulmonary infiltrates, unspecific mediastinal lymphadenopathy and enlargement of pulmonary lymph vessels. Bronchoscopy was performed and showed extensive occlusive bronchial casts. We diagnosed a case of bronchitis plastica. Therapy with inhalative heparin led to clinical improvement...
October 2017: Pneumologie
https://www.readbyqxmd.com/read/28994458/a-blind-deconvolution-method-incorporated-with-anatomical-based-filtering-for-partial-volume-correction-validations-with-123-i-mibg-cardiac-spect-ct
#8
Jing Wu, Hui Liu, Taraneh Hashemi Zonouz, Veronica M Sandoval, Hassan Mohy-Ud-Din, Rachel Lampert, Albert J Sinusas, Chi Liu, Yi-Hwa Liu
PURPOSE: Segmentation of contrast-enhanced CT and measurement of SPECT point spread function (PSF) are usually required for conventional partial volume correction (PVC). This study was to develop a segmentation-free method with blind deconvolution (BD) and anatomical-based filtering for SPECT PVC. METHODS: The proposed method was implemented using an iterative BD algorithm to estimate the restored image and the PSF simultaneously. An anatomical-based filtering was implemented at each iteration to reduce Gibbs artifact and suppress noise amplification in the deconvolution process...
October 10, 2017: Medical Physics
https://www.readbyqxmd.com/read/28993347/interrupted-aortic-arch-complicated-with-takotsubo-cardiomyopathy-mimicking-aortic-dissection
#9
Farhala Mari Baloch, Javed Majid Tai, Aamir Hameed Khan, Abdul Baqi
A 50-year-old man presented to the emergency department with interscapular pain, diaphoresis and restlessness. Initial examination raised the possibility of aortic dissection; however, the CT scan did not concur with the diagnosis. An ECG showed ST segment elevation in leads V1-V6 and echocardiography showed severe left ventricular systolic dysfunction. Coronary angiography through the right femoral artery was attempted but the diagnostic catheter could not be advanced to the ascending aorta. Radiocontrast injection showed complete obstruction of the descending aorta...
October 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28992382/arterial-inflammation-detected-with-18-f-fluoro-deoxyglucose-positron-emission-tomography-in-rheumatoid-arthritis
#10
Laura Geraldino-Pardilla, Afshin Zartoshti, Ayse Bag Ozbek, Jon T Giles, Richard Weinberg, Mona Kinkhabwala, Sabahat Bokhari, Joan M Bathon
OBJECTIVES: In addition to traditional risk factors, excess cardiovascular disease (CVD) in rheumatoid arthritis (RA) is attributed to enhanced vascular and/or systemic inflammation. In several small studies using (18) F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) to directly assess vascular inflammation, FDG uptake was higher in RA patients than controls. Using a substantially larger RA sample, we sought to identify RA-disease characteristics independently associated with vascular FDG uptake...
October 9, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28990065/inhibition-of-cardiotrophin%C3%A2-1-overexpression-is-involved-in-the-anti%C3%A2-fibrotic-effect-of-astrogaloside%C3%A2-iv
#11
Guizhi Jia, Bin Leng, Hongxin Wang, Hongliang Dai
Astragaloside IV (AsIV), one of the major active ingredients in Astragalus membranaceus, has demonstrated remarkable antifibrotic effects via its antioxidative activity. Cardiac fibrosis is an important pathological mechanism during cardiac remodelling associated with heart failure. In the present study, the mechanism underlying the antifibrotic effect of AsIV upon isoprenaline (ISO) stimulation was investigated. AsIV significantly improved cardiac fibrosis in vivo and dose‑dependently inhibited ISO‑induced CF proliferation in vitro...
September 29, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28989000/use-of-18-f-fdg-pet-ct-imaging-to-determine-internal-mammary-lymph-node-location-for-radiation-therapy-treatment-planning-in-breast-cancer-patients
#12
Tima Davidson, Merav Ben-David, Shira Galper, Tess Haskin, Megan Howes, Roland Scaife, Nayroz Kanana, Uri Amit, Noam Weizman, Bar Chikman, Elinor Goshen, Simona Ben-Haim, Zvi Symon, Jeffrey Goldstein
PURPOSE: Adjuvant internal mammary lymph node (IMN) radiation is often delivered with 2-dimensional techniques that use anatomic landmarks and predetermined depths for field placement and dose specification. In contrast, 3-dimensional planning uses the internal mammary vessels (IMVs) to localize the IMNs for planning. Our purpose was to determine if localization of the involved IMN (i-IMN) by (18)F-labeled fluorodeoxyglucose positron emission tomography-computed tomography ((18)F-FDG PET-CT) offers opportunities to improve treatment...
November 5, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28988831/calcification-remodeling-index-assessed-by-cardiac-ct-predicts-severe-coronary-stenosis-in-lesions-with-moderate-to-severe-calcification
#13
Mengmeng Yu, Yuehua Li, Wenbin Li, Zhigang Lu, Meng Wei, Jiayin Zhang
OBJECTIVES: To assess the diagnostic performance of the calcification remodeling index (RI) as assessed by coronary computed tomography angiography (coronary CTA) to predict the presence of severe coronary stenosis in atherosclerotic coronary lesions with moderate to severe calcification. METHODS: Patients who underwent coronary CTA and invasive coronary angiography (ICA) within one month and had moderately to severely calcified lesions as revealed by coronary CTA, were retrospectively included...
September 30, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28988256/primary-leiomyosarcoma-of-the-atrium-with-heterologous-differentiation
#14
Shaesta Zaidi, Sufia Husain, Dona Barakah
We report a case of a 47-year-old female who presented with breathlessness and palpitations for two weeks. On clinical evaluation, bilateral pedal edema was noticed. A CT pulmonary angiogram showed a mass in the left atrium causing significant obstruction to cardiovascular outflow. After extensive work-up, the mass was surgically resected. Histopathological findings from the acquired specimen revealed a high-grade leiomyosarcoma with extensive necrosis and heterologous (cartilaginous) differentiation. The early postoperative period was complicated by cardiac tamponade and the patient died on the second postoperative day due to ventricular arrhythmia, shock and multiorgan failure...
September 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/28987857/intracranial-hemorrhage-in-patients-with-durable-mechanical-circulatory-support-devices-institutional-review-and-proposed-treatment-algorithm
#15
Wyatt L Ramey, Robyn L Basken, Christina M Walter, Zain Khalpey, G Michael Lemole, Travis M Dumont
OBJECTIVE: Spontaneous intracranial hemorrhage (ICH) is frequently managed in neurosurgery. Patients with durable mechanical circulatory support devices, including total artificial hearts (TAHs) and left ventricular assist devices (LVADs) are often encountered in the setting of ICH. While durable mechanical circulatory support devices have improved survival and quality of life for patients with advanced heart failure, ICH is one of the most feared complications following LVAD and TAH implantation...
October 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28986773/feasibility-of-combined-risk-stratification-with-coronary-ct-angiography-and-stress-myocardial-spect-in-patients-with-chronic-coronary-artery-disease
#16
Tomonari Kiriyama, Yoshimitsu Fukushima, Hiromitsu Hayashi, Hitoshi Takano, Shin-Ichiro Kumita
OBJECTIVE: To examine the additional prognostic value of coronary CT angiography (CTA) over myocardial perfusion imaging (MPI) in patients with suspected or known coronary artery disease. METHODS: A series of 157 patients (mean age 69 ± 9 years; 76% male; median follow-up 49 months; range 12-82 months) underwent stress MPI with SPECT and coronary CTA within a 6-month interval. Summed stress score (SSS) and summed difference score (SDS) of stress MPI, number of vessels with stenosis, and presence of left main trunk stenosis and high-risk plaques on coronary CTA were examined...
October 6, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28985746/porcine-model-of-progressive-cardiac-hypertrophy-and-fibrosis-with-secondary-postcapillary-pulmonary-hypertension
#17
Mariann Gyöngyösi, Noemi Pavo, Dominika Lukovic, Katrin Zlabinger, Andreas Spannbauer, Denise Traxler, Georg Goliasch, Ljubica Mandic, Jutta Bergler-Klein, Alfred Gugerell, Andras Jakab, Zsuzsanna Szankai, Levente Toth, Rita Garamvölgyi, Gerald Maurer, Frederic Jaisser, Faiez Zannad, Thomas Thum, Sándor Bátkai, Johannes Winkler
BACKGROUND: Meaningful translational large animal models for cardiac diseases are indispensable for studying disease mechanisms, development of novel therapeutic strategies, and evaluation of potential drugs. METHODS: For induction of heart failure, cardiac hypertrophy and fibrosis, a bare metal stent was implanted in the descending aorta of growing pigs (n = 7), inducing pressure stress on the left ventricle (group HYPI). The constant stent size in growing pigs resulted in antegrade partial obstruction of the aortic flow with a gradual increase in afterload...
October 6, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28984730/intradevice-misalignment-predicts-residual-leak-in-patients-undergoing-left-atrial-appendage-closure
#18
Giuseppe Patti, Roberto Scipione, Gian P Ussia, Antonio Rapacciuolo, Costanza Goffredo, Pietro Sedati
AIMS: Postdeployment mutual orientation between the disk and the lobe in patients undergoing left atrial appendage closure with Amplatzer cardiac plug/Amulet device might impact on the risk of residual leak during follow-up. Thus, we evaluated in an exploratory, pilot study whether the degree of intradevice misalignment, measured by cardiac computed tomography (CT), discriminates the occurrence of peridevice leak in those patients. METHODS: All patients (N = 15) undergoing percutaneous left atrial appendage closure with those specific devices between April 2013 and January 2015 were prospectively included...
November 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28981808/evaluation-of-radiation-absorbed-dose-and-image-quality-in-different-retrospective-ecg-gating-acquisition-methods-of-cardiac-ct-angiography
#19
Shojaei Barjouei Nazli, Seyed Mahmoud Reza Aghamiri, Neda Gholizadeh Sendani, Amin Shams Akhtari
Cardiac computed tomography angiography (CCTA) studies have risen concern of radiobiological effects over the patients. Therefore, estimating radiation doses absorbed during CCTA is important. In this study, we compared radiation dose and image quality by using three different retrospective electrocardiography (ECG) protocols. A total of 123 patients undergoing CCTA were divided in three different groups. We used full-dose modulation (CareDose4D) technique in group (1); fixed tube current 200 mAs for group (2); and in group (3), chest circumference was used to adapt tube current (180-200 mAs) and tube potential (100-120 kVp)...
August 22, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28981185/infective-endocarditis-in-the-setting-of-renal-transplantation-case-report-and-review-of-the-literature
#20
Inbar Nardi Agmon, Elad Goldberg, Eytan Cohen, Ilan Krause
The potent immunosuppressive drugs used by transplant recipients places them at risk of infections. Data on infective endocarditis (IE) in the setting of renal transplantation (RT) are sparse. We describe a 36-year-old woman referred to a tertiary medical center for evaluation of elevated creatinine levels 1 month after a second RT. Work-up revealed the presence of all four of Duke's criteria: fever, persistent bacteremia, new-onset tricuspid regurgitation, and masses suspected to be vegetation attached to the tricuspid annulus...
October 5, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
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