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https://www.readbyqxmd.com/read/29785721/heeding-humanity-in-an-age-of-electronic-health-records-heidegger-levinas-and-healthcare
#1
Casey Rentmeester
The American Recovery and Reinvestment Act of 2009 (ARRA) required healthcare providers in the United States to adopt and demonstrate meaningful use of electronic health records (EHRs) by January 1, 2014. In many ways, EHRs mark a notable improvement over paper medical records as they are more easily accessible and allow for electronic searching and sharing of medical history. However, as EHRs have become mandated by ARRA, many nurses now rely upon computers far more heavily during nurse-patient interactions, thereby decreasing the level of direct interpersonal communication between the two...
May 21, 2018: Nursing Philosophy: An International Journal for Healthcare Professionals
https://www.readbyqxmd.com/read/29774893/prevalence-and-antimicrobial-sensitivity-pattern-of-urinary-tract-infection-among-children-with-cerebral-palsy-moshi-tanzania
#2
Amon Ryakitimbo, Rune Philemon, Festo Mazuguni, Levina Msuya
Background: Urinary tract infection (UTI) in children with cerebral palsy (CP) is a challenging yet common clinical condition. Children with CP bare the greatest risk of contracting UTI because of their difficulties in neuromotor control which lead to delay of bladder control, causing incomplete bladder emptying and urine retention. Method: This was an analytical cross-sectional study that was conducted from September 2016 to March 2017 at Comprehensive Community Based Rehabilitation in Tanzania - Moshi and Kilimanjaro Christian Medical Centre Neurological Pediatrics Outpatient Clinic...
2018: Pediatric Health, Medicine and Therapeutics
https://www.readbyqxmd.com/read/29771103/-an-introduction-to-the-thought-of-emmanuel-levinas-the-care-or-irreducible-worry-of-infinite-responsibility
#3
Philippe Svandra
Despite a particularly difficult approach, Emmanuel Levinas remains a philosopher who « speaks » quite naturally to caregivers. The reason is simple ; he is interested in an issue that has long been hidden in philosophy, but that directly affects care : vulnerability.However, it seems that his thinking has too often been watered down. By presenting it as a form of benevolent altruism, the radical, even subversive, aspect of the approach that he proposes to us is erased. Indeed, Levinassian responsibility is experienced first of all as a rupture, a violence that makes me the « hostage of others...
March 2018: Recherche en Soins Infirmiers
https://www.readbyqxmd.com/read/29764918/a-feed-forward-relay-integrates-the-regulatory-activities-of-bicoid-and-orthodenticle-via-sequential-binding-to-suboptimal-sites
#4
Rhea R Datta, Jia Ling, Jesse Kurland, Xiaotong Ren, Zhe Xu, Gozde Yucel, Jackie Moore, Leila Shokri, Isabel Baker, Timothy Bishop, Paolo Struffi, Rimma Levina, Martha L Bulyk, Robert J Johnston, Stephen Small
The K50 (lysine at amino acid position 50) homeodomain (HD) protein Orthodenticle (Otd) is critical for anterior patterning and brain and eye development in most metazoans. In Drosophila melanogaster , another K50HD protein, Bicoid (Bcd), has evolved to replace Otd's ancestral function in embryo patterning. Bcd is distributed as a long-range maternal gradient and activates transcription of a large number of target genes, including otd Otd and Bcd bind similar DNA sequences in vitro, but how their transcriptional activities are integrated to pattern anterior regions of the embryo is unknown...
May 15, 2018: Genes & Development
https://www.readbyqxmd.com/read/29738691/agonistic-and-antagonistic-effects-of-progesterone-derivatives-on-the-transcriptional-activity-of-nuclear-progesterone-receptor-b-in-yeast-model-system
#5
A O Michurina, A V Polikarpova, I S Levina, L E Kulikova, I V Zavarzin, A A Guseva, I A Morozov, P M Rubtsov, O V Smirnova, T A Shchelkunova
Identification of progesterone selective agonists and antagonists that act through one of the nuclear progesterone receptor isoforms is of particular importance for the development of tissue-specific drugs in gynecology and anticancer therapy. Fourteen pregna-D'6 - and pregna-D'3 -pentarane progesterone derivatives with 16α,17α-cycloalkane groups and two progesterone 3-deoxyderivatives were examined for their ability to regulate transcriptional activity of human nuclear progesterone receptor isoform B (nPR-B) expressed in Saccharomyces cerevisiae yeast...
May 2018: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/29522555/heterochronic-development-of-lateral-plates-in-the-three-spined-stickleback-induced-by-thyroid-hormone-level-alterations
#6
Aleksey A Bolotovskiy, Marina A Levina, Jacquelin DeFaveri, Juha Merilä, Boris A Levin
The three-spined stickleback Gasterosteus aculeatus is an important model for studying microevolution and parallel adaptation to freshwater environments. Marine and freshwater forms differ markedly in their phenotype, especially in the number of lateral plates, which are serially repeated elements of the exoskeleton. In fishes, thyroid hormones are involved in adaptation to salinity, as well as the developmental regulation of serially repeated elements. To study how thyroid hormones influence lateral plate development, we manipulated levels of triiodothyronine and thiourea during early ontogeny in a marine and freshwater population with complete and low plate phenotypes, respectively...
2018: PloS One
https://www.readbyqxmd.com/read/29500522/multigene-sequencing-reveals-heterogeneity-of-nlrp12-related-autoinflammatory-disorders
#7
Mikhail M Kostik, Evgeny N Suspitsin, Marina N Guseva, Anastasia S Levina, Anastasia Y Kazantseva, Anna P Sokolenko, Evgeny N Imyanitov
NLRP12-related autoinflammatory disease (NLRP12-AID) is an exceptionally rare autosomal dominant disorder caused by germline mutations in NLRP12 gene. Very few patients with NLRP12-AD have been identified worldwide; therefore, there is a scarcity of data on phenotypic presentation of this syndrome. Here we provide evidence that NLRP12-AID may have clinical manifestations characteristic for primary immune deficiencies (PID). 246 children with periodic fever (PF) of unknown origin were subjects to the next generation sequencing (NGS) analysis; 213 of these patients had signs of primary immunodeficiency (PID) manifested by recurrent infections, while 33 kids had isolated PF...
May 2018: Rheumatology International
https://www.readbyqxmd.com/read/29488504/-pseudohypoacusis-associated-with-munchausen-s-syndrome
#8
Yu V Levina, A L Guseva, E V Baibakova
The authors describe a rare clinical case of psychogenic hearing loss in a female patient presenting Munchausen's syndrome with special reference to the objective and subjective methods designed to evaluate the hearing ability and used for diagnostics of this condition.
2018: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/29488495/-the-characteristics-of-broad-band-tympanometry-in-the-volunteers-with-the-unaffected-hearing
#9
V T Pal'chun, N S Tropskaya, Yu V Levina, S P Efimova, A L Guseva
The objective of the present work was to elucidate the characteristics of broad-band tympanometry in the healthy subjects with the unaffected hearing ability. The study involved 54 volunteers (27 men and 27 women) at the age from 21 to 55 years exhibiting no pathologic changes in the ear system as confirmed by the tone threshold audiometry, otoacoustic emission, tympaometry at a frequency of 226 Hz, and reflexometry. All the participants of the study underwent absorbance measurements by broad-band tympanometry within the frequency range from 226 to 8,000 Hz at an ambient pressure...
2018: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/29488494/-the-specific-microbiological-and-clinical-features-of-acute-otitis-media
#10
A V Gurov, Yu V Levina, A L Guseva, Z G Elchueva, S P Efimova, M V Gordienko
The objective of the present study was to elucidate the specific features of the clinical course of acute otitis media as well as the peculiarities of the vestibular function and the microbial paysage associated with this pathological condition under the present-day conditions. The study included 135 patients presenting with acute otitis media (AOM) at different stages of the disease. The discharge obtained from the tympanic cavity of all the patients was examined with the use of polymerase chain reaction in real time, audiological and vestibulogical methods...
2018: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/29488493/-the-peculiar-features-of-the-clinical-course-of-meniere-s-disease-associated-with-benign-paroxysmal-positional-vertigo
#11
V T Pal'chun, O A Mel'nikov, Yu V Levina, A L Guseva
AIM: The objective of the present study was to evaluate the frequency of occurrence and clinical features of vertigo spells in the patients presenting with Ménière's disease (MD) associated with benign paroxysmal positional vertigo (BPPV). METHODS: A total of 104 patients with MD were available for the observation. All of them underwent the comprehensive examination that included the audiological study and vestibular tests, such as the Dix-Hallpike test and the roll-test for BPPV diagnostics...
2018: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/29325435/early-stages-of-hiv-treatment-cascade-in-people-living-with-hiv-in-saint-petersburg-russia
#12
M V Vetrova, O V Aleksandrova, A E Paschenko, S E Toropov, V V Rassokhin, R A Abyshev, O S Levina, L M Niccolai, R Heimer
The proportion of people living with HIV (PLWH) in need of antiretroviral therapy (ART) is growing rapidly in Russia. Successful treatment outcomes reduces disease progression and contributes to HIV epidemic control. We conducted a pilot study following 100 PLWH newly found eligible for ART in St. Petersburg, Russia. We determined the proportion of PLWH who initiated ART, remained in treatment, and achieved an undetectable VL during 6-month follow up. Semi-structured interviews were conducted prior the initiation of ART and progress along the cascade was assessed through medical chart review...
January 11, 2018: AIDS Care
https://www.readbyqxmd.com/read/29306786/differences-in-risk-behaviours-and-hiv-status-between-primary-amphetamines-and-opioid-injectors-in-estonia-and-russia
#13
Isabel Tavitian-Exley, Mathieu Maheu-Giroux, Lucy Platt, Robert Heimer, Anneli Uusküla, Olga Levina, Peter Vickerman, Marie-Claude Boily
BACKGROUND AND OBJECTIVE: People who inject drugs (PWID) account for over half of new HIV infections in Eastern Europe and central Asia, where opioids continue to be the dominant illicit drugs injected. Stimulants including amphetamines (ATS) have been associated with HIV infection risk in several settings. We sought to examine whether primary ATS injection was associated with greater HIV risk, compared to opioid injection in two European locales with significant HIV epidemics. METHODS: PWID in Kohtla-Järve and St...
March 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29220789/new-estrogen-receptor-antagonists-3-20-dihydroxy-19-norpregna-1-3-5-10-trienes-synthesis-molecular-modeling-and-biological-evaluation
#14
Yury V Kuznetsov, Inna S Levina, Alexander M Scherbakov, Olga E Andreeva, Irina V Fedyushkina, Andrey S Dmitrenok, Alexander S Shashkov, Igor V Zavarzin
New estrogen receptor α (ERα) antagonists - 3,20-dihydroxy-19-norpregna-1,3,5(10)-trienes containing an additional carbocyclic ring D' at the 16α,17α positions - were synthesized. The effects of the new compounds on the MCF-7 breast cancer cells and ERα activation were investigated. All the steroids studied were synthesized starting from estrone methyl ether. The scaffold of compounds containing the six-membered ring D' was constructed via the Diels-Alder reaction of butadiene with 3-methoxy-19-norpregna-1,3,5(10),16-tetraen-20-one 5...
January 1, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29142045/rapid-assay-for-detection-of-the-epidemiologically-important-central-asian-russian-strain-of-the-mycobacterium-tuberculosis-beijing-genotype
#15
LETTER
Igor Mokrousov, Ekaterina Chernyaeva, Anna Vyazovaya, Yuriy Skiba, Natalia Solovieva, Violeta Valcheva, Klavdia Levina, Natalya Malakhova, Wei-Wei Jiao, Lia Lima Gomes, Philip N Suffys, Marge Kütt, Nagima Aitkhozhina, A-Dong Shen, Olga Narvskaya, Viacheslav Zhuravlev
No abstract text is available yet for this article.
February 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29123063/lewis-acid-enhancement-by-hydrogen-bond-donors-for-asymmetric-catalysis
#16
Steven M Banik, Anna Levina, Alan M Hyde, Eric N Jacobsen
Small-molecule dual hydrogen-bond (H-bond) donors such as ureas, thioureas, squaramides, and guanidinium ions enjoy widespread use as effective catalysts for promoting a variety of enantioselective reactions. However, these catalysts are only weakly acidic and therefore require highly reactive electrophilic substrates to be effective. We introduce here a mode of catalytic activity with chiral H-bond donors that enables enantioselective reactions of relatively unreactive electrophiles. Squaramides are shown to interact with silyl triflates by binding the triflate counterion to form a stable, yet highly Lewis acidic, complex...
November 10, 2017: Science
https://www.readbyqxmd.com/read/29110480/lewis-acid-triggered-vinylcyclopropane-cyclopentene-rearrangement
#17
Olga A Ivanova, Alexey O Chagarovskiy, Alexey N Shumsky, Vasiliy D Krasnobrov, Irina I Levina, Igor V Trushkov
We report a mild Lewis acid induced isomerization of donor-acceptor cyclopropanes, containing an alkenyl moiety and diverse electron-withdrawing group(s) at the adjacent positions, into substituted cyclopentenes. We have found that 1,1,2-trisubstituted cyclopent-3-enes were exclusively obtained in yield of 51-99% when cyclopropanes with a 2-substituted alkenyl group as a donor underwent isomerization. For cyclopropanes bearing a trisubstituted alkenyl group either the corresponding cyclopent-3-enes or isomeric cyclopent-2-enes having two acceptor groups at the C(1) atom were formed, with the reaction selectivity being determined by the applied Lewis acid...
January 19, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29092043/emerging-resistant-clones-of-mycobacterium-tuberculosis-in-a-spatiotemporal-context
#18
Anna Vyazovaya, Klavdia Levina, Viacheslav Zhuravlev, Piret Viiklepp, Marge Kütt, Igor Mokrousov
Objectives: We assessed the genetic structure of the Mycobacterium tuberculosis population in Estonia with a special focus on major epidemic/endemic clones and drug resistance determinants. We investigated the hypothesis of the decisive impact of massive human influx on the locally circulating genotypes. Estonia received a mass immigration from Russia during 1945-90 followed by enhanced interaction with the EU since 1991. Methods: The study sample included M. tuberculosis isolates from patients newly diagnosed with TB in 2014 in North Estonia (including the capital Tallinn)...
February 1, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29077419/origins-of-stokes-shift-in-pbs-nanocrystals
#19
Oleksandr Voznyy, Larissa Levina, Feng-Jia Fan, Grant Walters, James Z Fan, Amirreza Kiani, Alexander H Ip, Susanna M Thon, Andrew Proppe, Mengxia Liu, Edward H Sargent
Stokes shift, an energy difference between the excitonic absorption and emission, is a property of colloidal quantum dots (CQDs) typically ascribed to splitting between dark and bright excitons. In some materials, e.g., PbS, CuInS2, CdHgTe, a Stokes shift of up to 200 meV is observed, substantially larger than the estimates of dark-bright state splitting or vibronic relaxations. The shift origin remains highly debated, as contradictory signatures of both surface and bulk character were reported for the Stokes-shifted electronic state...
October 27, 2017: Nano Letters
https://www.readbyqxmd.com/read/29039911/halide-re-shelled-quantum-dot-inks-for-infrared-photovoltaics
#20
James Z Fan, Mengxia Liu, Oleksandr Voznyy, Bin Sun, Larissa Levina, Rafael Quintero-Bermudez, Min Liu, Olivier Ouellette, F Pelayo García de Arquer, Sjoerd Hoogland, Edward H Sargent
Colloidal quantum dots are promising materials for tandem solar cells that complement silicon and perovskites. These devices are fabricated from solution phase; however, existing methods for making infrared-bandgap CQD inks suffer agglomeration and fusion during solution exchange. Here we develop a ligand exchange that provides robust surface protection and thereby avoids aggregation. First, we exchanged long oleic acid ligands to a mixed system comprising medium-chain ammonium and anionic chloride ligands; we then reshelled the surface using short halides and pseudohalide ligands that enabled transfer to a polar solvent...
October 20, 2017: ACS Applied Materials & Interfaces
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