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A V Polikarpova, A A Maslakova, I S Levina, L E Kulikova, Y V Kuznetsov, A A Guseva, T A Shchelkunova, I V Zavarzin, O V Smirnova
The search of selective agonists and antagonists of membrane progesterone receptors (mPRs) is a starting point for the study of progesterone signal transduction mechanisms mediated by mPRs, distinct from nuclear receptors. According to preliminary data, the ligand affinity for mPRs differs significantly from that for classical nuclear progesterone receptors (nPRs), which might indicate structural differences in the ligand-binding pocket of these proteins. In the present work, we analyzed the affinity of several progesterone derivatives for mPRs of human pancreatic adenocarcinoma BxPC3 cell line that is characterized by a high level of mPR mRNA expression and by the absence of expression of nPR mRNA...
February 2017: Biochemistry. Biokhimii︠a︡
Siby K George
This paper argues against the proposal of a system of compensated living donation in the global south, especially India, without recourse to essentialist ethics. It relies on the anti-essentialist ethical-ontology of Levinas for the claim that it is the concrete vulnerability of the suffering other, rather than any absolute moral imperative, that makes a market for organs unethical.
January 4, 2017: Indian Journal of Medical Ethics
Lawrence Burns
No abstract text is available yet for this article.
February 10, 2017: Journal of Medicine and Philosophy
Еvgeny Kolesnikov, Gopalu Karunakaran, Anna Godymchuk, Levina Vera, Andrey Grigorjevich Yudin, Alexander Gusev, Denis Kuznetsov
Nowadays, the demands for the nanoparticles are increasing due to their tremendous applications in various fields. As a consequence, the discharge of nanoparticles into the atmosphere and environment is also increasing, posing a health threat and environmental damage in terms of pollution. Thus, an extensive research is essential to evaluate the discharge of these nanoparticles into the environment. Keeping this in mind, the present investigation aimed to analyze the discharge of aerosol nanoparticles that are synthesized in the laboratory via chemical precipitation and spray pyrolysis methods...
January 23, 2017: Ecotoxicology and Environmental Safety
Rinat F Salikov, Konstantin P Trainov, Anastasia A Levina, Irina K Belousova, Michael G Medvedev, Yury V Tomilov
The rearrangement of cyclopropylketone arylhydrazones generated in situ from arylhydrazine hydrochlorides and ketones leads to formation of tryptamine derivatives. The use of (2-arylcyclopropyl)ethanones in the reactions with model 4-bromophenylhydrazine hydrochloride gives branched tryptamines with aryl groups in the α-position to the amino group, while (2-methylcyclopropyl)ethanone gives a mixture of α- and β-substituted products in a ratio of 1:3. The method was found effective in the synthesis of enantiomerically pure tryptamine...
December 16, 2016: Journal of Organic Chemistry
Gabriel Schreiber, Sofia Avissar, Alan Jotkowitz, Demian Halperin
The patient-psychiatrist relationship is a cornerstone of psychiatric professionalism and ethics. We discuss this topic along the axis of the Other and the Same, concepts defined by continental philosophy. The self of Anglo-American philosophy is typically described in individualistic terms. Individualism, autonomy and ideal self are valorized within the current model of care. These characteristics belong to the Lacanian Imaginary Order, which is the core of narcissism. Patients may yearn for another model of interaction...
December 14, 2016: Psychiatric Quarterly
L Namazova-Baranova, E Vishneva, E Dobrynina, A Alekseeva, J Levina, K Efendieva, Smirnov, E Antonova, N Voznesenskaya, L Selimzianova
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
L Namazova-Baranova, E Vishneva, E Dobrynina, A Alekseeva, J Levina, K Efendieva, Smirnov, E Antonova, N Voznesenskaya, L Selimzianova
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
L Namazova-Baranova, E Vishneva, E Dobrynina, A Alekseeva, J Levina, K Efendieva, V Smirnov, E Antonova, N Voznesenskaya, L Selimzianova
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Inna V Zolnikova, Vladimir V Strelnikov, Natalia A Skvortsova, Alexander S Tanas, Debmalya Barh, Elena V Rogatina, Irina V Egorova, Darja V Levina, Olga N Demenkova, Egor G Prikaziuk, Marianna E Ivanova
ABCA4-associated mutation screening is extensively performed in European, African, American and several other populations for various retinopathies. However, it has not been well studied in a Russian cohort. Using next-generation (325 genes inherited disease panel) and Sanger sequencing technologies for the first time we documented the spectrum of genetic variations in a Russian retinopathy cohort of 51 patients from 10 ethnic groups. We found ABCA4 variations in 70.5% cases and one case with BEST1 variation...
February 2017: European Journal of Medical Genetics
Harm-Peer Zimmermann
Aging Studies and Postcolonial Studies belong together in a rather fundamental way, given that they share profound theoretical roots and far-reaching critical perspectives. These derive not only from the more recent poststructuralist discourse on others but also, further back, from the existentialist discourse on others - particularly in issues relating to "The Look" as elaborated by Jean-Paul Sartre in his major philosophical treatise Being and Nothingness and in his reflections on racism, colonialism and humanism...
December 2016: Journal of Aging Studies
Tatiana D Nekipelova, Evgenii N Khodot, Olga N Klimovich Lygo, Lidiya N Kurkovskaya, Irina I Levina, Vladimir A Kuzmin
Novel hetarylazo dyes containing tetrazole and tetra- or dihydroquinoline moieties were synthesized and their spectral properties in solvents of different polarities and H-bonding abilities were examined. The dyes exhibit solvatochromism dramatically depending on the proton accepting ability of solvents: (DMSO > H2O > MeOH > ACN > CH2Cl2) and the dye concentration. Upon dilution the absorption maximum of the visible band shows a blue shift and the absorption coefficient of the maximum decreases...
November 30, 2016: Photochemical & Photobiological Sciences
Asya S Levina, Marina N Repkova, Elena V Bessudnova, Ekaterina I Filippova, Natalia A Mazurkova, Valentina F Zarytova
Background: The development of new antiviral drugs based on nucleic acids is under scrutiny. An important problem in this aspect is to find the most vulnerable conservative regions in the viral genome as targets for the action of these agents. Another challenge is the development of an efficient system for their delivery into cells. To solve this problem, we proposed a TiO2·PL-DNA nanocomposite consisting of titanium dioxide nanoparticles and polylysine (PL)-containing oligonucleotides. Results: The TiO2·PL-DNA nanocomposites bearing the DNA fragments targeted to different conservative regions of (-)RNA and (+)RNA of segment 5 of influenza A virus (IAV) were studied for their antiviral activity in MDCK cells infected with the H1N1, H5N1, and H3N2 virus subtypes...
2016: Beilstein Journal of Nanotechnology
Jennifer L Brown, Ralph J DiClemente, Jessica M Sales, Eve S Rose, Nicole K Gause, Polina Safonova, Olga Levina, Nikolay Belyakov, Vadim V Rassokhin
OBJECTIVE: Alcohol use is a prominent factor correlated with HIV risk behavior engagement. Hazardous drinking is prevalent among Russian women and may contribute to decreased condom use. Event-based studies suggest that HIV risk behaviors may vary based on situational factors including partner characteristics and alcohol use. This study investigated the effect of situational factors on condom use during the most recent sexual encounter among a sample of HIV-infected Russian women. METHOD: HIV-infected women (n = 239; mean age = 30...
November 2016: Journal of Studies on Alcohol and Drugs
Ivan Mikhailov, Sergey Komarov, Vera Levina, Alexander Gusev, Jean-Paul Issi, Denis Kuznetsov
Ultrasonic-assisted sulphuric acid leaching combined with a Fenton-like process, utilizing nanoscale zero-valent iron (nZVI), was investigated to enhance the leaching of zinc from the blast furnace sludge (BFS). The leaching of iron (Fe) and zinc (Zn) from the sludge was investigated using Milli-Q water/BFS ratio of 10 and varying the concentration of hydrogen peroxide, sulphuric acid, the temperature, the input energy for ultrasound irradiation, and the presence or absence of nZVI as a Fenton reagent. The results showed that with 1g/l addition of nZVI and 0...
September 22, 2016: Journal of Hazardous Materials
Berit Foss, Dagfinn Nåden, Katie Eriksson
The purpose of this article is to explore what the experience of events of truth can entail in hermeneutic dialogue with text as well as the significance this can have for hermeneutic methodology in caring science. Experience of events of truth is discussed based on Hans-Georg Gadamer's ontological perspective and on Emmanuel Levinas's ethical perspective. A veritable experience of an event of truth is a testimony to the responsibility we take for the Other and to our humanity. Experience of events of truth requires that there is a connection of esteem between ethics and ontology in the reader's understanding of what Hans-Georg Gadamer calls the subject matter (Sache)...
October 2016: Nursing Science Quarterly
Drake J Smith, Levina J Lin, Heesung Moon, Alexander T Pham, Xi Wang, Siyuan Liu, Sunjong Ji, Valerie Rezek, Saki Shimizu, Marlene Ruiz, Jennifer Lam, Deanna M Janzen, Sanaz Memarzadeh, Donald B Kohn, Jerome A Zack, Scott G Kitchen, Dong Sung An, Lili Yang
The humanized bone marrow-liver-thymus (BLT) mouse model harbors a nearly complete human immune system, therefore providing a powerful tool to study human immunology and immunotherapy. However, its application is greatly limited by the restricted supply of human CD34(+) hematopoietic stem cells and fetal thymus tissues that are needed to generate these mice. The restriction is especially significant for the study of human immune systems with special genetic traits, such as certain human leukocyte antigen (HLA) haplotypes or monogene deficiencies...
December 15, 2016: Stem Cells and Development
Anna K Gazha, Lyudmila A Ivanushko, Eleonora V Levina, Sergey N Fedorov, Tatyana S Zaporozets, Valentin A Stonik, Nataliya N Besednova
The action of seven polyhydroxylated sterol mono- and disulfates (1-7), isolated from ophiuroids, on innate and adaptive immunity was examined in in vitro and in vivo experiments. At least, three of them (1, 2 and 4) increased the functional activities of neutrophils, including levels of oxygen-dependent metabolism, adhesive and phagocytic properties, and induced the expression of pro-inflammatory cytokines TNF-α and IL-8. Compound 4 was the most active for enhancing the production of antibody forming cells in the mouse spleen...
June 2016: Natural Product Communications
Gemma K Gransbury, Peter Kappen, Chris J Glover, James N Hughes, Aviva Levina, Peter A Lay, Ian F Musgrave, Hugh H Harris
NAMI-A and KP1019 are Ru(III)-based anti-metastatic and cytotoxic anti-cancer drugs, respectively, and have been proposed to be activated by reduction to Ru(II). The potential reduction of NAMI-A and KP1019 in the hypoxic environment of a tumour model of neuroblastoma was examined. Normoxic, hypoxic and necrotic tumour tissues were modelled by multicellular spheroids of SH-SY5Y human neuroblastoma cells of various diameters (50-800 μm). The variation in spheroid environment was confirmed with pimonidazole staining...
August 1, 2016: Metallomics: Integrated Biometal Science
Linda Barlow-Mosha, Konstantia Angelidou, Jane Lindsey, Moherndran Archary, Mark Cotton, Sylvia Dittmer, Lee Fairlie, Enid Kabugho, Portia Kamthunzi, Arti Kinikar, Tapiwa Mbengeranwa, Levina Msuya, Pauline Sambo, Kunjal Patel, Emily Barr, Patrick Jean-Phillipe, Avy Violari, Lynne Mofenson, Paul Palumbo, Benjamin H Chi
BACKGROUND: The International Maternal Pediatric Adolescent AIDS Clinical Trials Network (IMPAACT) P1060 study demonstrated short-term superiority of lopinavir/ritonavir (LPV/r) over nevirapine (NVP) in antiretroviral therapy (ART), regardless of prior NVP exposure. However, NVP-based ART had a marginal benefit in CD4 percentage (CD4%) and growth. We compared 5-year outcomes from this clinical trial. METHODS: Human immunodeficiency virus (HIV)-infected, ART-eligible children were enrolled into 2 cohorts based on prior NVP exposure and randomized to NVP- or LPV/r-based ART...
October 15, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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