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https://www.readbyqxmd.com/read/28426112/travel-medicine-perspectives-of-select-travel-medicine-experts-practicing-in-the-asia-pacific-region
#1
Karin Leder, Sarah Borwein, Pornthep Chanthavanich, Santanu Chatterjee, Kaythi Htun, Aung Swi Prue Marma, Issaku Nakatani, Jin-Ju Ok, Levina Pakasi, Prativa Pandey, Watcharapong Piyaphanee, Priscilla Rupali, Eli Schwartz, Tadashi Shinozuka, Phi Truong Hoang Phu, Hiroshi Watanabe, Jenny Visser, Annelies Wilder-Smith, Min Zhang, Sarah L McGuinness
No abstract text is available yet for this article.
July 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28412273/efficient-inhibition-of-influenza-a-viral-replication-in-cells-by-deoxyribozymes-delivered-by-nanocomposites
#2
Marina Repkova, Asya Levina, Boris Chelobanov, Zinfer Ismagilov, Natalia Shatskaya, Sergei Baiborodin, Ekaterina Filippova, Natalia Mazurkova, Valentina Zarytova
Nucleic-acid-based drugs are a promising class of novel therapeutics; however, their use in medicine is widely limited because of insufficient delivery into cells. This article proposes a new delivery strategy of nucleic acid fragments into cells as components of TiO2-based nanocomposites. For the first time, unmodified Dz molecules were non-covalently immobilized on TiO2 nanoparticles precovered with polylysine (TiO2•PL) with the formation of (TiO2•PL)•Dz nanocomposites. DNAzymes in the proposed nanocomposites were shown to retain their ability to cleave the RNA target in a cell-free system with the same selectivity as unbound Dz molecules...
April 12, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28401668/stabilities-and-biological-activities-of-vanadium-drugs-what-is-the-nature-of-active-species
#3
Aviva Levina, Peter Andrew Lay
Diverse biological activities of vanadium(V) drugs mainly arise from their abilities to inhibit phosphate-dependent enzymes and to alter cell signaling. Initial interest focused on anti-diabetic activities but has shifted to anti-cancer and anti-parasitic drugs. V-based anti-diabetics are pro-drugs that release active components (e.g., H₂VO₄¯) in biological media. By contrast, V anti-cancer drugs are generally assumed to enter cells intact; however, speciation studies indicate that nearly all drugs are likely to react in cell culture media during in-vitro assays and the same would apply in vivo...
April 11, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28393337/-living-with-tolerable-burden-exploring-the-ethical-self-of-nurses-who-provide-end-of-life-care
#4
Ying-Chun Liu, Yu-Lun Tai, Hsien-Hsien Chiang
BACKGROUND: Providing end-of-life (EOL) care elicits complex emotions in nurses in the context of modern medicine. Nurses must not only watch their patients succumb to disease and death but also witness their suffering. PURPOSE: This qualitative study adopted the perspective of "the other", as proposed by Emmanuel Levinas, to understand the experience of nurses who provide EOL care and the possibilities of nurses build up their ethical selves within the context of modern medicine...
April 2017: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/28374136/high-cytotoxicity-of-vanadium-iv-complexes-with-1-10-phenanthroline-and-related-ligands-is-due-to-decomposition-in-cell-culture-medium
#5
Maria Le, Oliver Rathje, Aviva Levina, Peter A Lay
Cytotoxic effects of Metvan (cis-[V(IV)O(OSO3)(Me2phen)2], where Me2phen = 4,7-dimethyl-1,10-phenanthroline) and its analogues with 1,10-phenanthroline (phen) and 2,2'-bipyridine (bpy) ligands in cultured human lung cancer (A549) cells have been re-investigated in conjunction with reactivity of the V(IV) complexes in neutral aerated aqueous solutions and in cell culture medium. All the V(IV) complexes underwent rapid oxidation to the corresponding V(V) species (cis-[V(V)(O)2L2](+)), followed by release of free ligands (shown by electrospray mass spectrometry)...
April 3, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28371602/toward-gene-therapy-of-hypertension-experimental-study-on-hypertensive-isiah-rats
#6
M N Repkova, A S Levina, A A Seryapina, N V Shikina, E V Bessudnova, V F Zarytova, A L Markel
TiO2-based nanocomposites were prepared to deliver oligonucleotides into cells. The nanocomposites were designed by the immobilization of polylysine-containing oligonucleotides on TiO2-nanoparticles (TiO2·PL-DNA). We showed for the first time the possibility of using the proposed nanocomposites for treatment of hypertensive disease by introducing them into hypertensive ISIAH rats developed as a model of stress-sensitive arterial hypertension. The mRNA of the gene encoding angiotensin I-converting enzyme (ACE1) involved in the synthesis of angiotensin II was chosen as a target...
April 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28320297/selection-of-progesterone-derivatives-specific-to-membrane-progesterone-receptors
#7
A V Polikarpova, A A Maslakova, I S Levina, L E Kulikova, Y V Kuznetsov, A A Guseva, T A Shchelkunova, I V Zavarzin, O V Smirnova
The search of selective agonists and antagonists of membrane progesterone receptors (mPRs) is a starting point for the study of progesterone signal transduction mechanisms mediated by mPRs, distinct from nuclear receptors. According to preliminary data, the ligand affinity for mPRs differs significantly from that for classical nuclear progesterone receptors (nPRs), which might indicate structural differences in the ligand-binding pocket of these proteins. In the present work, we analyzed the affinity of several progesterone derivatives for mPRs of human pancreatic adenocarcinoma BxPC3 cell line that is characterized by a high level of mPR mRNA expression and by the absence of expression of nPR mRNA...
February 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28195535/the-unfair-trade-why-organ-sale-is-indefensible
#8
Siby K George
This paper argues against the proposal of a system of compensated living donation in the global south, especially India, without recourse to essentialist ethics. It relies on the anti-essentialist ethical-ontology of Levinas for the claim that it is the concrete vulnerability of the suffering other, rather than any absolute moral imperative, that makes a market for organs unethical.
January 4, 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28186531/what-does-the-patient-say-levinas-and-medical-ethics
#9
Lawrence Burns
No abstract text is available yet for this article.
February 10, 2017: Journal of Medicine and Philosophy
https://www.readbyqxmd.com/read/28126628/investigation-of-discharged-aerosol-nanoparticles-during-chemical-precipitation-and-spray-pyrolysis-for-developing-safety-measures-in-the-nano-research-laboratory
#10
Еvgeny Kolesnikov, Gopalu Karunakaran, Anna Godymchuk, Levina Vera, Andrey Grigorjevich Yudin, Alexander Gusev, Denis Kuznetsov
Nowadays, the demands for the nanoparticles are increasing due to their tremendous applications in various fields. As a consequence, the discharge of nanoparticles into the atmosphere and environment is also increasing, posing a health threat and environmental damage in terms of pollution. Thus, an extensive research is essential to evaluate the discharge of these nanoparticles into the environment. Keeping this in mind, the present investigation aimed to analyze the discharge of aerosol nanoparticles that are synthesized in the laboratory via chemical precipitation and spray pyrolysis methods...
January 23, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27983841/synthesis-of-branched-tryptamines-via-the-domino-cloke-stevens-grandberg-rearrangement
#11
Rinat F Salikov, Konstantin P Trainov, Anastasia A Levina, Irina K Belousova, Michael G Medvedev, Yury V Tomilov
The rearrangement of cyclopropylketone arylhydrazones generated in situ from arylhydrazine hydrochlorides and ketones leads to formation of tryptamine derivatives. The use of (2-arylcyclopropyl)ethanones in the reactions with model 4-bromophenylhydrazine hydrochloride gives branched tryptamines with aryl groups in the α-position to the amino group, while (2-methylcyclopropyl)ethanone gives a mixture of α- and β-substituted products in a ratio of 1:3. The method was found effective in the synthesis of enantiomerically pure tryptamine...
December 16, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27975176/the-patient-psychiatrist-relationship-on-the-axis-of-the-other-and-the-same
#12
Gabriel Schreiber, Sofia Avissar, Alan Jotkowitz, Demian Halperin
The patient-psychiatrist relationship is a cornerstone of psychiatric professionalism and ethics. We discuss this topic along the axis of the Other and the Same, concepts defined by continental philosophy. The self of Anglo-American philosophy is typically described in individualistic terms. Individualism, autonomy and ideal self are valorized within the current model of care. These characteristics belong to the Lacanian Imaginary Order, which is the core of narcissism. Patients may yearn for another model of interaction...
December 14, 2016: Psychiatric Quarterly
https://www.readbyqxmd.com/read/27971575/the-dynamics-of-quality-of-life-in-children-with-uncontrolled-severe-persistent-asthma
#13
L Namazova-Baranova, E Vishneva, E Dobrynina, A Alekseeva, J Levina, K Efendieva, Smirnov, E Antonova, N Voznesenskaya, L Selimzianova
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27971574/the-impact-on-long-term-targeted-therapy-with-omalizumab-on-the-quality-of-life-according-to-registry-of-children-with-uncontrolled-severe-persistent-asthma-russian-experience
#14
L Namazova-Baranova, E Vishneva, E Dobrynina, A Alekseeva, J Levina, K Efendieva, Smirnov, E Antonova, N Voznesenskaya, L Selimzianova
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27970533/pediatric-registry-of-patients-with-severe-persistent-uncontrolled-asthma-receiving-omalizumab
#15
L Namazova-Baranova, E Vishneva, E Dobrynina, A Alekseeva, J Levina, K Efendieva, V Smirnov, E Antonova, N Voznesenskaya, L Selimzianova
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27939946/stargardt-disease-associated-mutation-spectrum-of-a-russian-federation-cohort
#16
Inna V Zolnikova, Vladimir V Strelnikov, Natalia A Skvortsova, Alexander S Tanas, Debmalya Barh, Elena V Rogatina, Irina V Egorova, Darja V Levina, Olga N Demenkova, Egor G Prikaziuk, Marianna E Ivanova
ABCA4-associated mutation screening is extensively performed in European, African, American and several other populations for various retinopathies. However, it has not been well studied in a Russian cohort. Using next-generation (325 genes inherited disease panel) and Sanger sequencing technologies for the first time we documented the spectrum of genetic variations in a Russian retinopathy cohort of 51 patients from 10 ethnic groups. We found ABCA4 variations in 70.5% cases and one case with BEST1 variation...
February 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/27912859/alienation-and-alterity-age-in-the-existentialist-discourse-on-others
#17
Harm-Peer Zimmermann
Aging Studies and Postcolonial Studies belong together in a rather fundamental way, given that they share profound theoretical roots and far-reaching critical perspectives. These derive not only from the more recent poststructuralist discourse on others but also, further back, from the existentialist discourse on others - particularly in issues relating to "The Look" as elaborated by Jean-Paul Sartre in his major philosophical treatise Being and Nothingness and in his reflections on racism, colonialism and humanism...
December 2016: Journal of Aging Studies
https://www.readbyqxmd.com/read/27858050/novel-hetarylazo-dyes-containing-tetrazole-and-hydroquinoline-moieties-spectral-characteristics-solvatochromism-and-photochemistry
#18
Tatiana D Nekipelova, Evgenii N Khodot, Olga N Klimovich Lygo, Lidiya N Kurkovskaya, Irina I Levina, Vladimir A Kuzmin
Novel hetarylazo dyes containing tetrazole and tetra- or dihydroquinoline moieties were synthesized and their spectral properties in solvents of different polarities and H-bonding abilities were examined. The dyes exhibit solvatochromism dramatically depending on the proton accepting ability of solvents: (DMSO > H2O > MeOH > ACN > CH2Cl2) and the dye concentration. Upon dilution the absorption maximum of the visible band shows a blue shift and the absorption coefficient of the maximum decreases...
November 30, 2016: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/27826491/high-antiviral-effect-of-tio2%C3%A2-pl-dna-nanocomposites-targeted-to-conservative-regions-of-rna-and-rna-of-influenza-a-virus-in-cell-culture
#19
Asya S Levina, Marina N Repkova, Elena V Bessudnova, Ekaterina I Filippova, Natalia A Mazurkova, Valentina F Zarytova
Background: The development of new antiviral drugs based on nucleic acids is under scrutiny. An important problem in this aspect is to find the most vulnerable conservative regions in the viral genome as targets for the action of these agents. Another challenge is the development of an efficient system for their delivery into cells. To solve this problem, we proposed a TiO2·PL-DNA nanocomposite consisting of titanium dioxide nanoparticles and polylysine (PL)-containing oligonucleotides. Results: The TiO2·PL-DNA nanocomposites bearing the DNA fragments targeted to different conservative regions of (-)RNA and (+)RNA of segment 5 of influenza A virus (IAV) were studied for their antiviral activity in MDCK cells infected with the H1N1, H5N1, and H3N2 virus subtypes...
2016: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/27797699/alcohol-use-partner-characteristics-and-condom-use-among-hiv-infected-russian-women-an-event-level-study
#20
Jennifer L Brown, Ralph J DiClemente, Jessica M Sales, Eve S Rose, Nicole K Gause, Polina Safonova, Olga Levina, Nikolay Belyakov, Vadim V Rassokhin
OBJECTIVE: Alcohol use is a prominent factor correlated with HIV risk behavior engagement. Hazardous drinking is prevalent among Russian women and may contribute to decreased condom use. Event-based studies suggest that HIV risk behaviors may vary based on situational factors including partner characteristics and alcohol use. This study investigated the effect of situational factors on condom use during the most recent sexual encounter among a sample of HIV-infected Russian women. METHOD: HIV-infected women (n = 239; mean age = 30...
November 2016: Journal of Studies on Alcohol and Drugs
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