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Harm-Peer Zimmermann
Aging Studies and Postcolonial Studies belong together in a rather fundamental way, given that they share profound theoretical roots and far-reaching critical perspectives. These derive not only from the more recent poststructuralist discourse on others but also, further back, from the existentialist discourse on others - particularly in issues relating to "The Look" as elaborated by Jean-Paul Sartre in his major philosophical treatise Being and Nothingness and in his reflections on racism, colonialism and humanism...
December 2016: Journal of Aging Studies
Tatiana D Nekipelova, Evgenii N Khodot, Olga N Klimovich Lygo, Lidiya N Kurkovskaya, Irina I Levina, Vladimir A Kuzmin
Novel hetarylazo dyes containing tetrazole and tetra- or dihydroquinoline moieties were synthesized and their spectral properties in solvents of different polarities and H-bonding abilities were examined. The dyes exhibit solvatochromism dramatically depending on the proton accepting ability of solvents: (DMSO > H2O > MeOH > ACN > CH2Cl2) and the dye concentration. Upon dilution the absorption maximum of the visible band shows a blue shift and the absorption coefficient of the maximum decreases...
November 30, 2016: Photochemical & Photobiological Sciences
Asya S Levina, Marina N Repkova, Elena V Bessudnova, Ekaterina I Filippova, Natalia A Mazurkova, Valentina F Zarytova
Background: The development of new antiviral drugs based on nucleic acids is under scrutiny. An important problem in this aspect is to find the most vulnerable conservative regions in the viral genome as targets for the action of these agents. Another challenge is the development of an efficient system for their delivery into cells. To solve this problem, we proposed a TiO2·PL-DNA nanocomposite consisting of titanium dioxide nanoparticles and polylysine (PL)-containing oligonucleotides. Results: The TiO2·PL-DNA nanocomposites bearing the DNA fragments targeted to different conservative regions of (-)RNA and (+)RNA of segment 5 of influenza A virus (IAV) were studied for their antiviral activity in MDCK cells infected with the H1N1, H5N1, and H3N2 virus subtypes...
2016: Beilstein Journal of Nanotechnology
Jennifer L Brown, Ralph J DiClemente, Jessica M Sales, Eve S Rose, Nicole K Gause, Polina Safonova, Olga Levina, Nikolay Belyakov, Vadim V Rassokhin
OBJECTIVE: Alcohol use is a prominent factor correlated with HIV risk behavior engagement. Hazardous drinking is prevalent among Russian women and may contribute to decreased condom use. Event-based studies suggest that HIV risk behaviors may vary based on situational factors including partner characteristics and alcohol use. This study investigated the effect of situational factors on condom use during the most recent sexual encounter among a sample of HIV-infected Russian women. METHOD: HIV-infected women (n = 239; mean age = 30...
November 2016: Journal of Studies on Alcohol and Drugs
Ivan Mikhailov, Sergey Komarov, Vera Levina, Alexander Gusev, Jean-Paul Issi, Denis Kuznetsov
Ultrasonic-assisted sulphuric acid leaching combined with a Fenton-like process, utilizing nanoscale zero-valent iron (nZVI), was investigated to enhance the leaching of zinc from the blast furnace sludge (BFS). The leaching of iron (Fe) and zinc (Zn) from the sludge was investigated using Milli-Q water/BFS ratio of 10 and varying the concentration of hydrogen peroxide, sulphuric acid, the temperature, the input energy for ultrasound irradiation, and the presence or absence of nZVI as a Fenton reagent. The results showed that with 1g/l addition of nZVI and 0...
September 22, 2016: Journal of Hazardous Materials
Berit Foss, Dagfinn Nåden, Katie Eriksson
The purpose of this article is to explore what the experience of events of truth can entail in hermeneutic dialogue with text as well as the significance this can have for hermeneutic methodology in caring science. Experience of events of truth is discussed based on Hans-Georg Gadamer's ontological perspective and on Emmanuel Levinas's ethical perspective. A veritable experience of an event of truth is a testimony to the responsibility we take for the Other and to our humanity. Experience of events of truth requires that there is a connection of esteem between ethics and ontology in the reader's understanding of what Hans-Georg Gadamer calls the subject matter (Sache)...
October 2016: Nursing Science Quarterly
Drake J Smith, Levina J Lin, Heesung Moon, Alexander T Pham, Xi Wang, Siyuan Liu, Sunjong Ji, Valerie Rezek, Saki Shimizu, Marlene Ruiz, Jennifer Lam, Deanna M Janzen, Sanaz Memarzadeh, Donald B Kohn, Jerome A Zack, Scott G Kitchen, Dong Sung An, Lili Yang
The humanized bone marrow-liver-thymus (BLT) mouse model harbors a nearly complete human immune system, therefore providing a powerful tool to study human immunology and immunotherapy. However, its application is greatly limited by the restricted supply of human CD34(+) hematopoietic stem cells and fetal thymus tissues that are needed to generate these mice. The restriction is especially significant for the study of human immune systems with special genetic traits, such as certain human leukocyte antigen (HLA) haplotypes or monogene deficiencies...
October 18, 2016: Stem Cells and Development
Anna K Gazha, Lyudmila A Ivanushko, Eleonora V Levina, Sergey N Fedorov, Tatyana S Zaporozets, Valentin A Stonik, Nataliya N Besednova
The action of seven polyhydroxylated sterol mono- and disulfates (1-7), isolated from ophiuroids, on innate and adaptive immunity was examined in in vitro and in vivo experiments. At least, three of them (1, 2 and 4) increased the functional activities of neutrophils, including levels of oxygen-dependent metabolism, adhesive and phagocytic properties, and induced the expression of pro-inflammatory cytokines TNF-α and IL-8. Compound 4 was the most active for enhancing the production of antibody forming cells in the mouse spleen...
June 2016: Natural Product Communications
Gemma K Gransbury, Peter Kappen, Chris J Glover, James N Hughes, Aviva Levina, Peter A Lay, Ian F Musgrave, Hugh H Harris
NAMI-A and KP1019 are Ru(III)-based anti-metastatic and cytotoxic anti-cancer drugs, respectively, and have been proposed to be activated by reduction to Ru(II). The potential reduction of NAMI-A and KP1019 in the hypoxic environment of a tumour model of neuroblastoma was examined. Normoxic, hypoxic and necrotic tumour tissues were modelled by multicellular spheroids of SH-SY5Y human neuroblastoma cells of various diameters (50-800 μm). The variation in spheroid environment was confirmed with pimonidazole staining...
August 1, 2016: Metallomics: Integrated Biometal Science
Linda Barlow-Mosha, Konstantia Angelidou, Jane Lindsey, Moherndran Archary, Mark Cotton, Sylvia Dittmer, Lee Fairlie, Enid Kabugho, Portia Kamthunzi, Arti Kinikar, Tapiwa Mbengeranwa, Levina Msuya, Pauline Sambo, Kunjal Patel, Emily Barr, Patrick Jean-Phillipe, Avy Violari, Lynne Mofenson, Paul Palumbo, Benjamin H Chi
BACKGROUND: The International Maternal Pediatric Adolescent AIDS Clinical Trials Network (IMPAACT) P1060 study demonstrated short-term superiority of lopinavir/ritonavir (LPV/r) over nevirapine (NVP) in antiretroviral therapy (ART), regardless of prior NVP exposure. However, NVP-based ART had a marginal benefit in CD4 percentage (CD4%) and growth. We compared 5-year outcomes from this clinical trial. METHODS: Human immunodeficiency virus (HIV)-infected, ART-eligible children were enrolled into 2 cohorts based on prior NVP exposure and randomized to NVP- or LPV/r-based ART...
October 15, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
A M Scherbakov, I S Levina, L E Kulikova, I V Fedyushkina, V S Skvortsov, A V Veselovsky, Y V Kuznetsov, I V Zavarzin
The cytotoxic activity of synthetic progestins (pregna-D'-pentaranes) II-V full agonists of the progesterone receptor (PR) for PR-positive and PR-negative cells of human breast carcinoma was studied. These compounds were more active in the PR-positive MCF-7 cells than in the PR-negative MDA-MB-453 cells. Cytotoxic effects of tested compounds against normal epithelial MDCK cells were not found. Molecular modeling of studied steroids with PR showed that all progestins with close energy values can bind to the ligand binding domain (LBD) of PR and the magnitude of the energy exceeds the value estimated for the progesterone molecule...
March 2016: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
D L Muratov, M L Derbeneva, S P Efimova, Yu V Levina, A L Guseva
The rare clinical case of a patient with chronic otitis media and foreign body in the middle ear - a micro earphone in the tympanic cavity - is described in this article. The diagnostics, possible complications, and surgical treatment are discussed.
2016: Vestnik Otorinolaringologii
Nina Elisabeth Blegen, Katie Eriksson, Terese Bondas
The aim is to understand the experience of being cared for in psychiatric care as a patient and as a parent. Parenthood represents the natural form of human caring, a human directedness regardless of gender. The study has its starting point in this image, as it applies to mothers who receive care as provided in a psychiatric care context. The theoretical perspective is the theory of caritative caring, and the methodological approach is the philosophical hermeneutics outlined by Gadamer. The sample was purposeful: 10 mothers who experienced being a mother while suffering from mental illness and receiving care from professionals in psychiatric specialist health care contexts...
2016: International Journal of Qualitative Studies on Health and Well-being
Stefan Herning
BACKGROUND: Schizophrenia, in phenomenological psychopathology, is often described as a self disturbance and sometimes as a disturbance of the self-world relation. This study seeks to elaborate on these concepts by examining the significance of the Other in relation to these disturbances. METHOD: Levinas' account of the 'home' will be employed to interpret the phenomenon of 'positive withdrawal'. RESULTS: Positive withdrawal can be conceptualized as a means to domesticate the Other, and schizophrenia can be described as an alteration or absence of the normal mode of being at home in the world...
2016: Psychopathology
Kristin Håland, Ingela Lundgren, Eva Lidén, Tine S Eri
OBJECTIVE: Intimate partner violence (IPV) is a large public health problem with far-reaching consequences for those involved. The aim of this study was to explore fathers' experiences of change during pregnancy and early parenthood in the context of IPV. METHODS: The methodological approach in this interview study was hermeneutics, based on a lifeworld perspective. Ten men, who had subjected their partners to violence during the childbearing period, and had become fathers within the previous 6 years, participated...
2016: International Journal of Qualitative Studies on Health and Well-being
Rachel Andrew, Marika Tiggemann, Levina Clark
This study examined a range of predictors, based on previous theoretical models, of positive body image in young adult women. Participants were 266 women who completed an online questionnaire measuring body appreciation, activity participation, media consumption, perceived body acceptance by others, self-compassion, and autonomy. Potential mechanisms in predicting body appreciation assessed were self-objectification, social appearance comparison, and thin-ideal internalisation. Results indicated that greater perceived body acceptance by others and self-compassion, and lower appearance media consumption, self-objectification, social comparison, and thin-ideal internalisation were related to greater body appreciation...
September 2016: Body Image
Aviva Levina, T H Nguyen Pham, Peter A Lay
Cr(III) binding to transferrin (Tf; the main Fe(III) transport protein) has been postulated to mediate cellular uptake of Cr(III) to facilitate a purported essential role for this element. Experiments using HepG2 (human hepatoma) cells, which were chosen because of high levels of the transferrin receptor, showed that Cr(III) binding to vacant Fe(III) -binding sites of human Tf effectively blocks cellular Cr(III) uptake. Through bio-layer interferometry studies of the Tf cycle, it was found that both exclusion and efflux of Cr2 (III) Tf from cells was caused by 1) relatively low Cr2 Tf affinity to cell-surface Tf receptors compared to Fe2 Tf, and 2) disruption of metal release under endosomal conditions and post-endosomal Tf dissociation from the receptor...
July 4, 2016: Angewandte Chemie
Alexander P Dahinten, Dorothy E Dow, Coleen K Cunningham, Levina J Msuya, Blandina T Mmbaga, Robert A Malkin
BACKGROUND: In developing countries, antiretroviral therapy provides life-saving treatment to HIV-positive women and their children before, during and after birth. However, supply chain challenges such as long distances, medication shortages and nonfacility deliveries often compromise consistent access to prophylactic treatment for at-risk infants. A proposed intervention to address these challenges, often referred to as the "Pratt Pouch," allows for liquid-formulation medications, such as nevirapine (NVP), to be repackaged into single-dose pouches...
September 2016: Pediatric Infectious Disease Journal
S M Rastorguev, A V Nedoluzhko, M A Levina, E B Prokhorchuk, K G Skryabin, B A Levin
A pronounced pleiotropic effect of thyroid hormones on the regulation of gene expression in fish in postembryogenesis was demonstrated for the first time using larvae and juveniles of the blue bream Ballerus ballerus as an example. Genome-wide transcriptome sequencing (RNA-seq) identified 1212 differentially expressed genes in the brain and liver of fish kept in triiodothyronine solution (0.25 ng/mL). Our data show that the regulation of gene expression by thyroid hormones is widespread in nature: it involves not only the structural genes but also the regulatory genes...
March 2016: Doklady. Biochemistry and Biophysics
Jian Guo, Jie Cheng, Elizaveta Levina, George Michailidis, Ji Zhu
We consider the problem of jointly estimating a collection of graphical models for discrete data, corresponding to several categories that share some common structure. An example for such a setting is voting records of legislators on different issues, such as defense, energy, and healthcare. We develop a Markov graphical model to characterize the heterogeneous dependence structures arising from such data. The model is fitted via a joint estimation method that preserves the underlying common graph structure, but also allows for differences between the networks...
June 2015: Annals of Applied Statistics
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