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Levinas

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https://www.readbyqxmd.com/read/28900092/-impact-of-delivery-method-on-antiviral-activity-of-phosphodiester-phosphorothioate-and-phosphoryl-guanidine-oligonucleotides-in-mdck-cells-infected-with-h5n1-bird-flu-virus
#1
A S Levina, M N Repkova, B P Chelobanov, E V Bessudnova, N A Mazurkova, D A Stetsenko, V F Zarytova
We have previously described nanocomposites containing conjugates or complexes of native oligodeoxyribonucleotides with poly-L-lysine and TiO2 nanoparticles. We have shown that these nanocomposites efficiently suppressed influenza A virus reproduction in MDCK cells. Here, we have synthesized previously undescribed nanocomposites that consist of TiO2 nanoparticles and polylysine conjugates with oligonucleotides that contain phosphoryl guanidine or phosphorothioate internucleotide groups. These nanocomposites have been shown to exhibit antiviral activity in MDCK cells infected with H5N1 influenza A virus...
July 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/28864067/a-novel-chemoradiation-targeting-stem-and-nonstem-pancreatic-cancer-cells-by-repurposing-disulfiram
#2
Juan Cong, Yangyang Wang, Xiao Zhang, Nan Zhang, Ling Liu, Klara Soukup, Theodoros Michelakos, Theodore Hong, Albert DeLeo, Lei Cai, Francesco Sabbatino, Soldano Ferrone, Hang Lee, Vera Levina, Bryan Fuchs, Kenneth Tanabe, Keith Lillemoe, Cristina Ferrone, Xinhui Wang
Pancreatic ductal adenocarcinoma (PDAC) has a 5-year survival rate of 6% and is projected to be the second leading cause of cancer death by 2030, underscoring the urgency to develop new strategies to improve current therapeutic modalities for PDAC. Targeting pancreatic cancer stem cells (PCSCs), which are resistant to radiation and chemotherapy, is a promising strategy. A novel approach which can be readily clinically translated is to repurpose disulfiram (DSF), a drug for treating alcoholism, to target PCSCs...
August 30, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28699018/polydrug-use-and-heterogeneity-in-hiv-risk-among-people-who-inject-drugs-in-estonia-and-russia-a-latent-class-analysis
#3
Isabel Tavitian-Exley, Marie-Claude Boily, Robert Heimer, Anneli Uusküla, Olga Levina, Mathieu Maheu-Giroux
Non-medical drug injection is a major risk factor for HIV infection in Russia and Estonia. Multiple drug use (polydrug) has further been associated with increased harms. We compared HIV, injecting and sexual risk associated with polydrug use among people who injected drugs (PWID) in 2012-2013 in Kohtla-Järve (Estonia, n = 591) and St Petersburg (Russia, n = 811). Using latent class analysis, we identified five (poly)drug classes, the largest consisting of single-drug injectors among whom an opioid was the sole drug injected (56% of PWID)...
July 11, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28545094/economic-evaluation-of-policy-options-for-dialysis-in-end-stage-renal-disease-patients-under-the-universal-health-coverage-in-indonesia
#4
Afiatin, Levina Chandra Khoe, Erna Kristin, Lusiana Siti Masytoh, Eva Herlinawaty, Pitsaphun Werayingyong, Mardiati Nadjib, Sudigdo Sastroasmoro, Yot Teerawattananon
OBJECTIVES: This study aims to assess the value for money and budget impact of offering hemodialysis (HD) as a first-line treatment, or the HD-first policy, and the peritoneal dialysis (PD) first policy compared to a supportive care option in patients with end-stage renal disease (ESRD) in Indonesia. METHODS: A Markov model-based economic evaluation was performed using local and international data to quantify the potential costs and health-related outcomes in terms of life years (LYs) and quality-adjusted life years (QALYs)...
2017: PloS One
https://www.readbyqxmd.com/read/28506425/fluoroquinolone-resistance-in-streptococcus-pneumoniae-isolates-in-germany-from-2004-2005-to-2014-2015
#5
Julia Schmitz, Mark van der Linden, Adnan Al-Lahham, Natalia Levina, Mathias W Pletz, Matthias Imöhl
Streptococcus pneumoniae is a major cause of bacterial pneumonia, sepsis and meningitis worldwide. Prevalence of levofloxacin-resistant S. pneumoniae isolates in Germany and associated mutations in the quinolone resistance determining regions (QRDRs), as well as serotype distribution and multi locus sequence types (MLST) are shown. 21,764 invasive S. pneumoniae isolates from Germany, isolated in the epidemiological seasons from 2004/05 to 2014/15 were analyzed at the German National Reference Centre for Streptococci (GNRCS) for their levofloxacin resistance by micro broth dilution method...
June 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/28497980/the-association-between-cigarette-smoking-virologic-suppression-and%C3%A2-cd4-%C3%A2-lymphocyte-count-in-hiv-infected-russian-women
#6
Jennifer L Brown, Theresa Winhusen, Ralph J DiClemente, Jessica M Sales, Eve S Rose, Polina Safonova, Olga Levina, Nikolay Belyakov, Vadim V Rassokhin
Cigarette smoking among people living with HIV/AIDS is associated with significant morbidity and mortality, but findings regarding the association between cigarette smoking and HIV viral load and CD4+ lymphocyte counts have been inconsistent. This study characterized the prevalence of cigarette smoking among HIV-infected Russian women and examined the association between smoking frequency and quantity and HIV viral load and CD4+ lymphocyte counts. HIV-infected Russian women (N = 250; M age = 30.0) in St...
September 2017: AIDS Care
https://www.readbyqxmd.com/read/28483894/finding-hope-in-the-face-to-face
#7
Jennifer Y C Edgoose, Julian M Edgoose
What does it mean to look into the face of a patient who looks back? Face-to-face encounters are at the heart of the patient-clinician relationship but their singular significance is often lost amid the demands of today's high-tech, metric-driven health care systems. Using the framework provided by the philosopher and Holocaust survivor Emmanuel Levinas, the authors explore the unique responsibility and potential for hope found only in face-to-face encounters. Revisiting this most fundamental attribute of medicine is likely our greatest chance to reclaim who we are as clinicians and why we do what we do...
May 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/28469176/subsampling-scaling
#8
A Levina, V Priesemann
In real-world applications, observations are often constrained to a small fraction of a system. Such spatial subsampling can be caused by the inaccessibility or the sheer size of the system, and cannot be overcome by longer sampling. Spatial subsampling can strongly bias inferences about a system's aggregated properties. To overcome the bias, we derive analytically a subsampling scaling framework that is applicable to different observables, including distributions of neuronal avalanches, of number of people infected during an epidemic outbreak, and of node degrees...
May 4, 2017: Nature Communications
https://www.readbyqxmd.com/read/28426112/travel-medicine-perspectives-of-select-travel-medicine-experts-practicing-in-the-asia-pacific-region
#9
Karin Leder, Sarah Borwein, Pornthep Chanthavanich, Santanu Chatterjee, Kaythi Htun, Aung Swi Prue Marma, Issaku Nakatani, Jin-Ju Ok, Levina Pakasi, Prativa Pandey, Watcharapong Piyaphanee, Priscilla Rupali, Eli Schwartz, Tadashi Shinozuka, Phi Truong Hoang Phu, Hiroshi Watanabe, Jenny Visser, Annelies Wilder-Smith, Min Zhang, Sarah L McGuinness
No abstract text is available yet for this article.
July 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28412273/efficient-inhibition-of-influenza-a-viral-replication-in-cells-by-deoxyribozymes-delivered-by-nanocomposites
#10
Marina Repkova, Asya Levina, Boris Chelobanov, Zinfer Ismagilov, Natalia Shatskaya, Sergei Baiborodin, Ekaterina Filippova, Natalia Mazurkova, Valentina Zarytova
Nucleic-acid-based drugs are a promising class of novel therapeutics; however, their use in medicine is widely limited because of insufficient delivery into cells. This article proposes a new delivery strategy of nucleic acid fragments into cells as components of TiO2-based nanocomposites. For the first time, unmodified Dz molecules were non-covalently immobilized on TiO2 nanoparticles precovered with polylysine (TiO2•PL) with the formation of (TiO2•PL)•Dz nanocomposites. DNAzymes in the proposed nanocomposites were shown to retain their ability to cleave the RNA target in a cell-free system with the same selectivity as unbound Dz molecules...
June 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28401668/stabilities-and-biological-activities-of-vanadium-drugs-what-is-the-nature-of-the-active-species
#11
REVIEW
Aviva Levina, Peter A Lay
Diverse biological activities of vanadium(V) drugs mainly arise from their abilities to inhibit phosphatase enzymes and to alter cell signaling. Initial interest focused on anti-diabetic activities but has shifted to anti-cancer and anti-parasitic drugs. V-based anti-diabetics are pro-drugs that release active components (e.g., H2 VO4(-) ) in biological media. By contrast, V anti-cancer drugs are generally assumed to enter cells intact; however, speciation studies indicate that nearly all drugs are likely to react in cell culture media during in vitro assays and the same would apply in vivo...
April 11, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28393337/-living-with-tolerable-burden-exploring-the-ethical-self-of-nurses-who-provide-end-of-life-care
#12
Ying-Chun Liu, Yu-Lun Tai, Hsien-Hsien Chiang
BACKGROUND: Providing end-of-life (EOL) care elicits complex emotions in nurses in the context of modern medicine. Nurses must not only watch their patients succumb to disease and death but also witness their suffering. PURPOSE: This qualitative study adopted the perspective of "the other", as proposed by Emmanuel Levinas, to understand the experience of nurses who provide EOL care and the possibilities of nurses build up their ethical selves within the context of modern medicine...
April 2017: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/28374136/high-cytotoxicity-of-vanadium-iv-complexes-with-1-10-phenanthroline-and-related-ligands-is-due-to-decomposition-in-cell-culture-medium
#13
Maria Le, Oliver Rathje, Aviva Levina, Peter A Lay
Cytotoxic effects of Metvan (cis-[V(IV)O(OSO3)(Me2phen)2], where Me2phen = 4,7-dimethyl-1,10-phenanthroline) and its analogues with 1,10-phenanthroline (phen) and 2,2'-bipyridine (bpy) ligands in cultured human lung cancer (A549) cells have been re-investigated in conjunction with reactivity of the V(IV) complexes in neutral aerated aqueous solutions and in cell culture medium. All the V(IV) complexes underwent rapid oxidation to the corresponding V(V) species (cis-[V(V)(O)2L2](+)), followed by release of free ligands (shown by electrospray mass spectrometry)...
July 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28371602/toward-gene-therapy-of-hypertension-experimental-study-on-hypertensive-isiah-rats
#14
M N Repkova, A S Levina, A A Seryapina, N V Shikina, E V Bessudnova, V F Zarytova, A L Markel
TiO2-based nanocomposites were prepared to deliver oligonucleotides into cells. The nanocomposites were designed by the immobilization of polylysine-containing oligonucleotides on TiO2-nanoparticles (TiO2·PL-DNA). We showed for the first time the possibility of using the proposed nanocomposites for treatment of hypertensive disease by introducing them into hypertensive ISIAH rats developed as a model of stress-sensitive arterial hypertension. The mRNA of the gene encoding angiotensin I-converting enzyme (ACE1) involved in the synthesis of angiotensin II was chosen as a target...
April 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28320297/selection-of-progesterone-derivatives-specific-to-membrane-progesterone-receptors
#15
A V Polikarpova, A A Maslakova, I S Levina, L E Kulikova, Y V Kuznetsov, A A Guseva, T A Shchelkunova, I V Zavarzin, O V Smirnova
The search of selective agonists and antagonists of membrane progesterone receptors (mPRs) is a starting point for the study of progesterone signal transduction mechanisms mediated by mPRs, distinct from nuclear receptors. According to preliminary data, the ligand affinity for mPRs differs significantly from that for classical nuclear progesterone receptors (nPRs), which might indicate structural differences in the ligand-binding pocket of these proteins. In the present work, we analyzed the affinity of several progesterone derivatives for mPRs of human pancreatic adenocarcinoma BxPC3 cell line that is characterized by a high level of mPR mRNA expression and by the absence of expression of nPR mRNA...
February 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28195535/the-unfair-trade-why-organ-sale-is-indefensible
#16
Siby K George
This paper argues against the proposal of a system of compensated living donation in the global south, especially India, without recourse to essentialist ethics. It relies on the anti-essentialist ethical-ontology of Levinas for the claim that it is the concrete vulnerability of the suffering other, rather than any absolute moral imperative, that makes a market for organs unethical.
July 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28186531/what-does-the-patient-say-levinas-and-medical-ethics
#17
Lawrence Burns
The patient-physician relationship is of primary importance for medical ethics, but it also teaches broader lessons about ethics generally. This is particularly true for the philosopher Emmanuel Levinas whose ethics is grounded in the other who "faces" the subject and whose suffering provokes responsibility. Given the pragmatic, situational character of Levinasian ethics, the "face of the other" may be elucidated by an analogy with the "face of the patient." To do so, I draw on examples from Martin Winckler's fictional physician narratives...
April 1, 2017: Journal of Medicine and Philosophy
https://www.readbyqxmd.com/read/28126628/investigation-of-discharged-aerosol-nanoparticles-during-chemical-precipitation-and-spray-pyrolysis-for-developing-safety-measures-in-the-nano-research-laboratory
#18
Еvgeny Kolesnikov, Gopalu Karunakaran, Anna Godymchuk, Levina Vera, Andrey Grigorjevich Yudin, Alexander Gusev, Denis Kuznetsov
Nowadays, the demands for the nanoparticles are increasing due to their tremendous applications in various fields. As a consequence, the discharge of nanoparticles into the atmosphere and environment is also increasing, posing a health threat and environmental damage in terms of pollution. Thus, an extensive research is essential to evaluate the discharge of these nanoparticles into the environment. Keeping this in mind, the present investigation aimed to analyze the discharge of aerosol nanoparticles that are synthesized in the laboratory via chemical precipitation and spray pyrolysis methods...
May 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27983841/synthesis-of-branched-tryptamines-via-the-domino-cloke-stevens-grandberg-rearrangement
#19
Rinat F Salikov, Konstantin P Trainov, Anastasia A Levina, Irina K Belousova, Michael G Medvedev, Yury V Tomilov
The rearrangement of cyclopropylketone arylhydrazones generated in situ from arylhydrazine hydrochlorides and ketones leads to formation of tryptamine derivatives. The use of (2-arylcyclopropyl)ethanones in the reactions with model 4-bromophenylhydrazine hydrochloride gives branched tryptamines with aryl groups in the α-position to the amino group, while (2-methylcyclopropyl)ethanone gives a mixture of α- and β-substituted products in a ratio of 1:3. The method was found effective in the synthesis of enantiomerically pure tryptamine...
January 6, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27975176/the-patient-psychiatrist-relationship-on-the-axis-of-the-other-and-the-same
#20
Gabriel Schreiber, Sofia Avissar, Alan Jotkowitz, Demian Halperin
The patient-psychiatrist relationship is a cornerstone of psychiatric professionalism and ethics. We discuss this topic along the axis of the Other and the Same, concepts defined by continental philosophy. The self of Anglo-American philosophy is typically described in individualistic terms. Individualism, autonomy and ideal self are valorized within the current model of care. These characteristics belong to the Lacanian Imaginary Order, which is the core of narcissism. Patients may yearn for another model of interaction...
December 14, 2016: Psychiatric Quarterly
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