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https://www.readbyqxmd.com/read/28087871/poison-ivy-how-effective-are-available-treatments
#1
Cara K Vaught, James W Mold
In this study, only one treatment approach significantly reduced pruritus. Three approaches were often associated with recurrences of rash or symptoms.
November 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/28087838/does-the-assessment-of-non-disjunction-provide-a-more-sensitive-assay-for-detection-of-aneugens
#2
Joanne M Elloway, Alexandra K Davies, Julie Hayes, Ann T Doherty
The detection of aneugenic chemicals is important due to the implications of aneuploidy for human health. Aneuploidy can result from chromosome loss or non-disjunction due to chromosome mis-segregation at anaphase. Frequently, aneugens are detected using the in vitro micronucleus assay (IVM), with either centromere or kinetochore labelling. However, this method does not consider non-disjunction, the suggested predominant mechanism of spindle poison induced aneugenicity in primary human lymphocytes. Therefore, the IVM may be relatively insensitive in detecting aneuploidy...
January 13, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28087833/dysregulation-of-map-kinase-signaling-pathways-including-p38mapk-sapk-jnk-and-erk1-2-in-cultured-rat-cerebellar-astrocytes-exposed-to-diphenylarsinic-acid
#3
Takayuki Negishi, Mami Matsumoto, Yayoi Kobayashi, Mikiya Kojima, Fumika Sakaguchi, Kazuaki Takahata, Tomoko Kanehira, Rina Arakaki, Yohei Aoyama, Hikari Yoshida, Rena Yamada, Nobutaka Sumiyoshi, Tomoko Tashiro, Seishiro Hirano, Kenji Yoshida, Kazunori Yukawa
Diphenylarsinic acid (DPAA) was a major compound found in the arsenic poisoning incident that occurred in Kamisu, Ibaraki, Japan in 2003. People exposed to DPAA via contaminated well water suffered from several neurological disorders, including cerebellar symptoms. We previously reported that DPAA induces cellular activation in cultured rat cerebellar astrocytes, dose-dependent promotion of cell growth (low DPAA), cell death (high DPAA), and increased phosphorylation of mitogen-activated protein (MAP) kinases (p38MAPK, SAPK/JNK, and ERK1/2)...
January 13, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28087659/plant-parasitic-nematodes-towards-understanding-molecular-players-in-stress-responses
#4
REVIEW
François-Xavier Gillet, Caroline Bournaud, Jose Dijair Antonino de Souza Júnior, Maria Fatima Grossi-de-Sa
BACKGROUND: Plant-parasitic nematode interactions occur within a vast molecular plant immunity network. Following initial contact with the host plant roots, plant-parasitic nematodes (PPNs) activate basal immune responses. Defence priming involves the release in the apoplast of toxic molecules derived from reactive species or secondary metabolism. In turn, PPNs must overcome the poisonous and stressful environment at the plant-nematode interface. The ability of PPNs to escape this first line of plant immunity is crucial and will determine its virulence...
January 13, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28080046/application-of-2-aminothiazoline-4-carboxylic-acid-as-a-forensic-marker-of-cyanide-exposure
#5
Monika Rużycka, Joanna Giebułtowicz, Marcin Fudalej, Paweł Krajewski, Piotr Wroczyński
Cyanides are infamous for their highly poisonous properties. Accidental cyanide poisoning occurs frequently, but occasionally, intentional poisonings also occur. Inhalation of fumes generated by fire may also cause cyanide poisoning. There are many limitations in direct analysis of cyanide. 2-Aminothiazoline-4-carboxylic acid (ATCA), a cyanide metabolite, seems to be the only surrogate that is being used in the detection of cyanide because of its stability and its cyanide-dependent quality in biological matrix...
January 12, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28079530/can-intoxication-status-be-used-as-a-prediction-tool-for-manner-of-death-a-comparison-of-the-intoxication-status-in-violent-suicides-and-homicides
#6
D Kimberley Molina, Veronica M Hargrove
Determining the manner of death in medicolegal death investigations can be difficult. The investigator relies on many facets of death investigation, including the circumstances of death and autopsy examination. A study was designed to analyze whether the intoxication status of the decedent could be used as another tool in death investigations. The intoxication status of violent (nonoverdose or poisoning) suicides and homicides was retrospectively reviewed and compared. A total of 625 deaths were identified, including 366 suicides and 259 homicides...
January 10, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28079044/chorea-as-unusual-complication-of-fungicide-poisoning
#7
B S Paul, G Paul, J Kaur, G Singh
Chorea is a rare manifestation of poisoning. We report an index case of a young woman who developed generalized chorea following propiconazole toxin ingestion. As large series on neurological complications of toxic compounds are difficult to be compiled, it is of interest to report our experience. This report adds one more compound to the increasing list of toxic chorea.
January 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/28078916/in-vivo-protection-studies-of-bis-quaternary-2-hydroxyimino-n-pyridin-3-yl-acetamide-derivatives-hnk-oximes-against-tabun-and-soman-poisoning-in-swiss-albino-mice
#8
P Kumar, D Swami, D P Nagar, K P Singh, J Acharya, H N Karade, R Yadav
The study reports antidotal efficacy of three HNK [ bis quaternary 2-(hydroxyimino)-N-(pyridin-3yl) acetamide derivatives] and pralidoxime (2-PAM), against soman and tabun poisoning in Swiss albino mice. Protection index (PI) was determined (treatment doses: HNK oximes, ×0.20 of their median lethal dose (LD50) and 2-PAM, 30 mg/kg, intramuscularly (im)) together with atropine (10 mg/kg, intraperitoneally). Probit log doses with difference of 0.301 log of LD50 of the nerve agents administered and inhibition of acetylcholinesterase (AChE) activity by 50% (IC50) was calculated at optimized time in brain and serum...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28077781/effects-of-an-unusual-poison-identify-a-lifespan-role-for-topoisomerase-2-in-saccharomyces-cerevisiae
#9
Gregory Tombline, Jonathan I Millen, Bogdan Polevoda, Matan Rapaport, Bonnie Baxter, Michael Van Meter, Matthew Gilbertson, Joe Madrey, Gary A Piazza, Lynn Rasmussen, Krister Wennerberg, E Lucile White, John L Nitiss, David S Goldfarb
A progressive loss of genome maintenance has been implicated as both a cause and consequence of aging. Here we present evidence supporting the hypothesis that an age-associated decay in genome maintenance promotes aging in Saccharomyces cerevisiae (yeast) due to an inability to sense or repair DNA damage by topoisomerase 2 (yTop2). We describe the characterization of LS1, identified in a high throughput screen for small molecules that shorten the replicative lifespan of yeast. LS1 accelerates aging without affecting proliferative growth or viability...
January 5, 2017: Aging
https://www.readbyqxmd.com/read/28077608/-holiday-sickness-reported-exploratory-outcome-of-over-500-united-kingdom-holidaymakers-with-travellers-diarrhoea
#10
Prof Aali J Sheen, M Saad B Zahid, Andrew Fagbemi, Catherine Fullwood, Kathryn Whitehead
AIMS: To ascertain any predictors of potential food poisoning pathogens and development of post-infective irritable bowel syndrome (IBS) in UK travellers. An analysis was undertaken on prospectively collected data on 527 patients reporting symptoms of suspected food poisoning between June 2012 and June 2015. MAIN OUTCOME MEASURES: Positive stool sample indicative of food poisoning pathogens and diagnosis of post-infective IBS. RESULTS: Data on 527 patients were examined...
January 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28077358/biological-signaling-by-carbon-monoxide-and-carbon-monoxide-releasing-molecules-co-rms
#11
Roberto Motterlini, Roberta Foresti
Carbon monoxide (CO) is continuously produced in mammalian cells during degradation of heme. It is a stable gaseous molecule that reacts selectively with transition metals in a specific redox state and these characteristics restrict the interaction of CO with defined biological targets that transduce its signaling activity. Because of the high affinity of CO for ferrous heme, these targets can be grouped into heme-containing proteins, representing a large variety of sensors and enzymes with a series of diverse function in the cell and the organism...
January 11, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28076943/repetition-rate-after-non-fatal-self-poisoning-in-sri-lanka-a-one-year-prospective-longitudinal-study
#12
T N Rajapakse, K M Griffiths, S Cotton, H Christensen
Introduction: Attempted or non-fatal self-poisoning is an important public health problem in Sri Lanka. Current evidence from Sri Lanka suggests that this phenomenon is more common among young people, and females, and is associated with a recent interpersonal conflict. International studies indicate that recent non-fatal selfharm is associated with an increased risk of repetition and completed suicide. Prospective follow-up data regarding rates of repetition of self-harm in Sri Lanka is limited...
30, 2016: Ceylon Medical Journal
https://www.readbyqxmd.com/read/28076550/suicide-in-university-students-in-bogot%C3%A3-colombia-2004-2014
#13
Saúl Alonso Franco, Martha Lucia Gutiérrez, Julián Sarmiento, Decsy Cuspoca, Javier Tatis, Alejandro Castillejo, Miguel Barrios, Magnolia Del Pilar Ballesteros-Cabrera, Sara Zamora, Carlos Iván Rodríguez
We report the results of a retrospective, descriptive, qualitative study of suicide among university students in Bogotá, Colombia. The objective of this study was to document the magnitude, principal characteristics, and impact of this phenomenon in the selected population. A semi-structured survey was employed to collect information from 66 individuals linked to the universities. A total of 45 cases of suicide were documented in the study period (2004 - 2014). Of these, 69% occurred in males and 31% in females...
January 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28074717/endosulfan-poisoning-in-canids-and-felids-in-the-calabria-region-of-southern-italy
#14
Antonella De Roma, Carmela Rossini, Caterina Riverso, Giorgio Galiero, Mauro Esposito
Endosulfan, a highly toxic insecticide and acaricide, was globally banned under the Stockholm Convention in May 2011 because of its threats to human health and the environment. Despite the ban on its use, endosulfan is still present in the environment, causing poisoning events in domestic animals and wildlife. Toxicologic analysis of poisoned animals conducted by the Istituto Zooprofilattico Sperimentale del Mezzogiorno revealed that in the past 3 y, this pesticide has not disappeared in the regions of interest...
January 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28074704/the-toxicology-of-zinc-chloride-smoke-producing-bombs-and-screens
#15
Ayman El Idrissi, Lisanne van Berkel, Nadia E Bonekamp, Diana J Z Dalemans, Marcel A G van der Heyden
CONTEXT: Zinc chloride (ZnCl2)-based smoke bombs and screens are in use since the Second World War (1939-1945). Many case descriptions on ZnCl2 smoke inhalation incidents appeared since 1945. OBJECTIVE: We provide a comprehensive overview of the clinical symptoms and underlying pathophysiology due to exposure to fumes from ZnCl2 smoke producing bombs. In addition, we give a historical overview of treatment regimens and their outcomes. METHODOLOGY: We performed a literature search on Medline, Scopus and Google Scholar databases using combinations of the following search terms "smoke bomb", "smoke screen", "ZnCl2", "intoxication", "poisoning", "case report", "HE smoke", "hexachloroethane smoke", "smoke inhalation" and "white smoke"...
January 11, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28074668/in-vivo-evidence-of-nephrotoxicity-and-altered-hepatic-function-in-rats-following-administration-of-diglycolic-acid-a-metabolite-of-diethylene-glycol
#16
Corie N Robinson, Brian Latimer, Fleurette Abreo, Kiera Broussard, Kenneth E McMartin
CONTEXT: Diglycolic acid (DGA) is one of the two primary metabolites of diethylene glycol (DEG). DEG is an industrial solvent that has been implicated in mass poisonings resulting from product misuse in the United States and worldwide, with the hallmark toxicity being acute kidney injury, hepatotoxicity, encephalopathy and peripheral neuropathy. Our laboratory has generated in-vitro evidence suggesting that DGA is the metabolite responsible for the proximal tubule necrosis and decreased kidney function observed following DEG ingestion...
January 11, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28074520/assessing-the-accuracy-of-opioid-overdose-and-poisoning-codes-in-diagnostic-information-from-electronic-health-records-claims-data-and-death-records
#17
Carla A Green, Nancy A Perrin, Shannon L Janoff, Cynthia I Campbell, Howard D Chilcoat, Paul M Coplan
PURPOSE: The purpose of this study is to assess positive predictive value (PPV), relative to medical chart review, of International Classification of Diseases (ICD)-9/10 diagnostic codes for identifying opioid overdoses and poisonings. METHODS: Data were obtained from Kaiser Permanente Northwest and Northern California. Diagnostic data from electronic health records, submitted claims, and state death records from Oregon, Washington, and California were linked. Individual opioid-related poisoning codes (e...
January 10, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28074383/poisoning-the-pika-must-protection-of-grasslands-be-at-the-expense-of-biodiversity
#18
Lan Wu, Hao Wang
No abstract text is available yet for this article.
January 10, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28074125/shiga-vero-toxin-producing-escherichia-coli-isolated-from-the-hospital-foods-virulence-factors-o-serogroups-and-antimicrobial-resistance-properties
#19
Reza Ranjbar, Mojtaba Masoudimanesh, Farhad Safarpoor Dehkordi, Nematollah Jonaidi-Jafari, Ebrahim Rahimi
BACKGROUND: According to the presence of the weak, diabetic and immunosuppressive patients in hospitals, hospital foods should have a high quality and safety. Cooking a lot of foods higher than daily requirement, storage of cooked foods in an inappropriate condition and presence of nurses and servants in distribution of food to patients are the main reasons caused contamination of hospital foods. Shiga toxigenic Escherichia coli is one of the common cause of food poisoning in hospitals...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28073672/the-long-story-of-camptothecin-from-traditional-medicine-to-drugs
#20
REVIEW
Emanuela Martino, Serena Della Volpe, Elisa Terribile, Emanuele Benetti, Mirena Sakaj, Adriana Centamore, Andrea Sala, Simona Collina
20-(S)-Camptothecin (CPT) is a natural alkaloid extracted from the bark of Camptotheca acuminata (Chinese happy tree). It acts as a DNA topoisomerase 1 poison with an interesting antitumor activity and its use is limited by low stability and solubility and unpredictable drug-drug interactions. Since the late 20th century, it has been widely used in cancer therapy and, since extraction yields from plant tissues are very low, various synthetic routes have been developed to satisfy the increase in demand for CPT...
December 31, 2016: Bioorganic & Medicinal Chemistry Letters
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