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https://www.readbyqxmd.com/read/28634905/capsule-commentary-on-rigotti-et-al-interactive-voice-response-calls-to-promote-smoking-cessation-after-hospital-discharge-pooled-analysis-of-two-randomized-clinical-trials
#1
Steven A Schroeder
No abstract text is available yet for this article.
June 20, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28634151/speech-and-swallowing-abnormalities-in-adults-with-polg-associated-ataxia-polg-a
#2
Adam P Vogel, Natalie Rommel, Andreas Oettinger, Marius Horger, Patrick Krumm, Eva-Maria Kraus, Ludger Schöls, Matthis Synofzik
BACKGROUND: Mutations in the nuclear-encoded mitochondrial DNA polymerase gamma (POLG) can result in a wide spectrum of neurological deficits. A common presentation is progressive ataxia (POLG-A) which includes impaired speech and swallowing. The nature, severity and impact of these deficits in POLG-A is not known. A comprehensive quantitative and qualitative characterization of dysarthria and dysphagia in this recurrent ataxia disorder will assist in diagnostics, provide insights into the underlying pathology, and establish the foundation for future therapy trials...
June 17, 2017: Mitochondrion
https://www.readbyqxmd.com/read/28632098/utility-and-accuracy-of-perceptual-voice-and-speech-distinctions-in-the-diagnosis-of-parkinson-s-disease-psp-and-msa-p
#3
Nick Miller, Uma Nath, Emma Noble, David Burn
AIM: To determine if perceptual speech measures distinguish people with Parkinson's disease (PD), multiple system atrophy with predominant parkinsonism (MSA-P) and progressive supranuclear palsy (PSP). METHODS: Speech-language therapists blind to patient characteristics employed clinical rating scales to evaluate speech/voice in 24 people with clinically diagnosed PD, 17 with PSP and 9 with MSA-P, matched for disease duration (mean 4.9 years, standard deviation 2...
June 20, 2017: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/28631679/-the-comparative-assessment-of-the-vocal-function-in-the-professional-voice-users-and-non-occupational-voice-users-in-the-late-adulthood
#4
O G Pavlikhin, S G Romanenko, D I Krasnikova, E V Lesogorova, V S Yakovlev
The objective of the present study was to evaluate the clinical and functional condition of the voice apparatus in the elderly patients and to elaborate recommendations for the prevention of disturbances of the vocal function in the professional voice users. This comprehensive study involved 95 patients including the active professional voice users (n=48) and 45 non-occupational voice users at the age from 61 to 82 years with the employment history varying from 32 to 51 years. The study was designed to obtain the voice characteristics by means of the subjective auditory assessment, microlaryngoscopy, video laryngostroboscopy, determination of maximum phonation time (MPT), and computer-assisted acoustic analysis of the voice with the use of the MDVP Kay Pentaxy system...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28629258/implementation-and-preliminary-evaluation-of-c-tone-a-novel-algorithm-to-improve-lexical-tone-recognition-in-mandarin-speaking-cochlear-implant-users
#5
Lichuan Ping, Ningyuan Wang, Guofang Tang, Thomas Lu, Li Yin, Wenhe Tu, Qian-Jie Fu
OBJECTIVES: Because of limited spectral resolution, Mandarin-speaking cochlear implant (CI) users have difficulty perceiving fundamental frequency (F0) cues that are important to lexical tone recognition. To improve Mandarin tone recognition in CI users, we implemented and evaluated a novel real-time algorithm (C-tone) to enhance the amplitude contour, which is strongly correlated with the F0 contour. METHODS: The C-tone algorithm was implemented in clinical processors and evaluated in eight users of the Nurotron NSP-60 CI system...
June 20, 2017: Cochlear Implants International
https://www.readbyqxmd.com/read/28626811/the-enrich-study-to-evaluate-the-effectiveness-of-a-combination-intervention-package-to-improve-isoniazid-preventive-therapy-initiation-adherence-and-completion-among-people-living-with-hiv-in-ethiopia-rationale-and-design-of-a-mixed-methods-cluster-randomized
#6
Andrea A Howard, Yael Hirsch-Moverman, Suzue Saito, Tsigereda Gadisa, Amrita Daftary, Zenebe Melaku
BACKGROUND: Isoniazid preventive therapy (IPT) prevents tuberculosis among HIV-positive individuals, however implementation is suboptimal. Implementation science studies are needed to identify interventions to address this evidence-to-program gap. OBJECTIVE: The ENRICH Study is a mixed methods cluster randomized trial aimed at evaluating the effectiveness and acceptability of a combination intervention package (CIP) to improve IPT implementation in Ethiopia. DESIGN: Ten health centers were randomized to receive the CIP or standard of care...
June 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/28623857/vincristine-induced-neuropathy-in-pediatric-patients-with-acute-lymphoblastic-leukemia-in-oman-frequent-autonomic-and-more-severe-cranial-nerve-involvement
#7
Hanan F Nazir, Amna AlFutaisi, Mathew Zacharia, Mohamed Elshinawy, Surekha T Mevada, Abdulhakim Alrawas, Doaa Khater, Deepali Jaju, Yasser Wali
BACKGROUND: Vincristine (VCR) induced peripheral neuropathy is a common complication in children with acute lymphoblastic leukemia (ALL). PROCEDURES: A retrospective data analysis over an interval of 10 years (2006-2016) of all children with ALL seen at Sultan Qaboos University Hospital was carried out. Electronic medical records of eligible patients were reviewed. Patients with clinical evidence of neuropathy and abnormal nerve conduction studies (NCSs) were included in the study...
June 17, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28621572/changes-to-international-non-proprietary-names-for-antibody-therapeutics-2017-and-beyond-of-mice-men-and-more%C3%A2
#8
Paul W H I Parren, Paul J Carter, Andreas Plückthun
Active pharmaceutical substances require an International Nonproprietary Name (INN)assigned by the World Health Organization (WHO) to obtain market authorization as a medicinal product. INNsare selected to represent a unique, generic namefor a drug enablingunambiguous identification by stakeholders worldwide. INNs may be requested after initiating clinical development of an investigational drug. Pharmaceutical classes are indicated by a common stem or suffix. Currently, INNsfor monoclonal antibody-based drugs are recognized by the suffix, -mab,preceded by a source infixsuch as-xi- (chimeric),-zu- (humanized) or -u- (human) designating the species from which the antibody was derived...
June 16, 2017: MAbs
https://www.readbyqxmd.com/read/28620323/integrated-trauma-focused-cognitive-behavioural-therapy-for-post-traumatic-stress-and-psychotic-symptoms-a-case-series-study-using-imaginal-reprocessing-strategies
#9
Nadine Keen, Elaine C M Hunter, Emmanuelle Peters
Despite high rates of trauma in individuals with psychotic symptoms, post-traumatic stress symptoms are frequently overlooked in clinical practice. There is also reluctance to treat post-traumatic symptoms in case the therapeutic procedure of reprocessing the trauma exacerbates psychotic symptoms. Recent evidence demonstrates that it is safe to use reprocessing strategies in this population. However, most published studies have been based on treating post-traumatic symptoms in isolation from psychotic symptoms...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28616847/interactive-voice-response-calls-to-promote-smoking-cessation-after-hospital-discharge-pooled-analysis-of-two-randomized-clinical-trials
#10
Nancy A Rigotti, Yuchiao Chang, Lisa C Rosenfeld, Sandra J Japuntich, Elyse R Park, Hilary A Tindle, Douglas E Levy, Zachary Z Reid, Joanna Streck, Timothy Gomperts, Jennifer H K Kelley, Daniel E Singer
BACKGROUND: Hospitalization offers smokers an opportunity to quit smoking. Starting cessation treatment in hospital is effective, but sustaining treatment after discharge is a challenge. Automated telephone calls with interactive voice response (IVR) technology could support treatment continuance after discharge. OBJECTIVE: To assess smokers' use of and satisfaction with an IVR-facilitated intervention and to test the relationship between intervention dose and smoking cessation...
June 14, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28615760/use-of-mobile-phone-technology-to-improve-follow-up-at-a-community-mental-health-clinic-a-randomized-control-trial
#11
Gaurav Singh, Narayana Manjunatha, Sabina Rao, H N Shashidhara, Sydney Moirangthem, Rajendra K Madegowda, B Binukumar, Mathew Varghese
BACKGROUND: Mobile phone technology is being used worldwide to improve follow-ups in health care. AIM: Aim of the study is to evaluate whether the use of mobile technology will improve or not the follow-up of Indian patients from a community mental health center. MATERIALS AND METHODS: Patients or caregivers having mobile phones and consenting for study were enrolled, and sociodemographic and clinical details of patients were taken. Participants were randomized into two groups (short message service [SMS] vs...
May 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28615149/cardiovascular-and-metabolic-effects-of-metformin-in-patients-with-type-1-diabetes-removal-a-double-blind-randomised-placebo-controlled-trial
#12
John R Petrie, Nishi Chaturvedi, Ian Ford, Martijn C G J Brouwers, Nicola Greenlaw, Therese Tillin, Irene Hramiak, Alun D Hughes, Alicia J Jenkins, Barbara E K Klein, Ronald Klein, Teik C Ooi, Peter Rossing, Coen D A Stehouwer, Naveed Sattar, Helen M Colhoun
BACKGROUND: Metformin might reduce insulin requirement and improve glycaemia in patients with type 1 diabetes, but whether it has cardiovascular benefits is unknown. We aimed to investigate whether metformin treatment (added to titrated insulin therapy) reduced atherosclerosis, as measured by progression of common carotid artery intima-media thickness (cIMT), in adults with type 1 diabetes at increased risk for cardiovascular disease. METHODS: REMOVAL was a double-blind, placebo-controlled trial undertaken at 23 hospital diabetes clinics in five countries (Australia, Canada, Denmark, the Netherlands, and the UK)...
June 9, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28607898/a-study-of-clinicopathological-profile-of-patients-of-hoarseness-of-voice-presenting-to-tertiary-care-hospital
#13
Smita Soni, Sanchay Chouksey
Hoarseness is subjective term used to describe abnormal voice quality which may occur due to many causes because it is just a symptom. Proper knowledge and clinicopathological profile is important to treat the underlying pathology. This prospective study was carried out in 100 patients presented in Department of ENT, Gandhi Medical College, Bhopal from April 2013 to September 2014 with complaint of hoarseness of voice for more than 15 days. Objective of this study is to study incidence, duration and sex predilection for hoarseness of voice...
June 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28606181/women-s-views-and-experiences-of-a-mobile-phone-based-intervention-to-support-post-abortion-contraception-in-cambodia
#14
Chris Smith, Sokhey Ly, Vannak Uk, Ruby Warnock, Caroline Free
BACKGROUND: The MObile Technology for Improved Family Planning (MOTIF) trial assessed a mobile phone-based intervention comprising voice messages and counsellor support to increase post-abortion contraception at four Marie Stopes International clinics in Cambodia. The aim of this process evaluation was to assess women's views and experiences of receiving the MOTIF intervention, gain insights into the mechanism of action of the intervention and seek recommendations for improvements. METHODS: We conducted a qualitative study comprising15 semi-structured interviews with women who had received the intervention and undertook a simple thematic analysis...
June 12, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28606080/the-challenges-of-emerging-hiss-in-bridging-the-communication-gaps-among-physicians-and-nurses-in-china-an-interview-study
#15
Dong Wen, Xingting Zhang, Jie Wan, Jing Fu, Jianbo Lei
BACKGROUND: To explore the current situation, existing problems and possible causes of said problems with regards to physician-nurse communication under an environment of increasingly widespread usage of Hospital Information Systems and to seek out new potential strategies in information technology to improve physician-nurse communication. METHODS: Semi-structured interviews were conducted with 20 physicians and nurses in five leading tertiary grade A hospitals in Beijing, China (two physicians and two nurses in each hospital)...
June 12, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28602633/automated-cleft-speech-evaluation-using-speech-recognition
#16
Megan Vucovich, Rami R Hallac, Alex A Kane, Julie Cook, Cortney Van'T Slot, James R Seaward
Perceptual evaluation remains the gold-standard evaluation of cleft speech, but with any human interpretation, there can be bias. Eliminating bias, allowing comparison of speech data between units, is labor and time intensive. Globally, there is a shortage of listeners. We have developed a computer learning system to evaluate cleft speech. Our automated cleft speech evaluator interprets resonance and articulatory cleft speech errors. Speech recognition engines typically ignore voice characteristics and speech errors of the speaker, but in cleft speech evaluation, these features are paramount...
May 17, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28601293/from-dizziness-to-severe-ataxia-and-dysarthria-new-cases-of-anti-ca-arhgap26-autoantibody-associated-cerebellar-ataxia-suggest-a-broad-clinical-spectrum
#17
Ulrike Wallwitz, Sebastian Brock, Antje Schunck, Brigitte Wildemann, Sven Jarius, Frank Hoffmann
In 2010, a novel anti-neuronal autoantibody, termed anti-Ca, was described in a patient with subacute cerebellar ataxia, and Rho GTPase-activating protein 26 (ARHGAP26) was identified as the target antigen. Recently, three additional cases of anti-Ca-positive cerebellar ataxia have been published. In addition to ataxia, cognitive decline and depression have been observed in some patients. Here, we report two new cases of anti-Ca-associated autoimmune cerebellar ataxia. Patient 1 presented with dizziness and acute yet mild limb and gait ataxia...
August 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28599523/threshold-of-oscillation-of-a-vocal-fold-replica-with-unilateral-surface-growths
#18
Paul Luizard, Xavier Pelorson
Among vocal fold diseases, the presence of a surface growth is often encountered and can be considered a public health issue. While more energy is required to achieve phonation than in healthy cases, this situation can lead to a wide range of voice perturbations, from a change of voice quality to aphonia. The present study aims at providing finer comprehension of the physical phenomena underlying this type of pathological phonation process. A vocal fold replica is used to perform measurements of mechanical responses of each vocal fold as well as of the subglottal pressure in both healthy and pathological configurations...
May 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28596101/utility-of-laryngeal-high-speed-videoendoscopy-in-clinical-voice-assessment
#19
Stephanie R C Zacharias, Dimitar D Deliyski, Terri Treman Gerlach
OBJECTIVE: This study aimed to assess the utility of laryngeal high-speed videoendoscopy (HSV) as a clinical tool. DESIGN: This is a prospective study of 151 patients. METHODS: A total of 151 adult patients (52 male, 99 female) underwent both videoendoscopy with stroboscopy (videostroboscopy) and HSV examination as part of a routine clinical voice assessment. At the time of the examination, ratings for videostroboscopy were reported in the clinical report...
June 5, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28596043/tildrakizumab-versus-placebo-or-etanercept-for-chronic-plaque-psoriasis-resurface-1-and-resurface-2-results-from-two-randomised-controlled-phase-3-trials
#20
Kristian Reich, Kim A Papp, Andrew Blauvelt, Stephen K Tyring, Rodney Sinclair, Diamant Thaçi, Kristine Nograles, Anish Mehta, Nicole Cichanowitz, Qing Li, Kenneth Liu, Carmen La Rosa, Stuart Green, Alexa B Kimball
BACKGROUND: Tildrakizumab is a high-affinity, humanised, IgG1 κ antibody targeting interleukin 23 p19 that represents an evolving treatment strategy in chronic plaque psoriasis. Previous research suggested clinical improvement with inhibition of interleukin 23 p19. We did two phase 3 trials to investigate whether tildrakizumab is superior to placebo and etanercept in the treatment of chronic plaque psoriasis. METHODS: We did two three-part, parallel group, double-blind, randomised controlled studies, reSURFACE 1 (at 118 sites in Australia, Canada, Japan, the UK, and the USA) and reSURFACE 2 (at 132 sites in Europe, Israel, and the USA)...
June 5, 2017: Lancet
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