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https://www.readbyqxmd.com/read/29913530/low-voice-spasmodic-dysphonia-and-hand-dystonia-as-clinical-clues-for-kmt2b-associated-early-onset-dystonia
#1
Annette Hackenberg, Matias Wagner, Jan Pahnke, Petra Zeitler, Eugen Boltshauser
No abstract text is available yet for this article.
June 18, 2018: Neuropediatrics
https://www.readbyqxmd.com/read/29903437/cerebellar-motor-syndrome-from-children-to-the-elderly
#2
Mario Manto
More than a century after the description of its cardinal components, the cerebellar motor syndrome (CMS) remains a cornerstone of daily clinical ataxiology, in both children and adults. Anatomically, motor cerebellum involves lobules I-V, VI, and VIII. CMS is typically associated with errors in the metrics of voluntary movements and a lack of coordination. Symptoms and motor signs consist of speech deficits, impairments of limb movements, and abnormalities of posture/gait. Ataxic dysarthria has a typical scanning (explosive with staccato) feature, voice has a nasal character, and speech is slurred...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29898859/widening-of-posterior-glottis-through-rotation-of-the-arytenoid-on-its-axis-report-of-nine-cases
#3
Luis F Tintinago, William Victoria, Estephania Candelo, Juan Camilo Diaz, Juan Carlos Arce, Luis Miguel Aristizabal, Claudia Sanz, Maria Claudia Montes, Maria A Velez-Esquivia
INTRODUCTION: Bilateral vocal folds' immobility is a challenge in laryngology. Multiple procedures have been proposed to improve breathing by statically enlarging the glottal airway, what also results in loss of voice and aspiration. We proposed a technique to enlarge the posterior glottis by rotating the arytenoids on its axis, imitating the function of the posterior cricoarytenoid muscle, with the objective of evaluating the results regarding decannulation, voice quality, and bronchoaspiration...
June 5, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29897573/neurocognitive-safety-after-96-weeks-on-dual-therapy-with-atazanavir-ritonavir-plus-lamivudine-results-of-the-neurocognitive-substudy-of-the-salt-randomized-clinical-trial
#4
Ignacio Pérez-Valero, Juan Pasquau, Rafael Rubio, Antonio Rivero, José Santos, Jesus Sanz, Ana Mariño, Manel Crespo, Jose Hernández-Quero, José Antonio Iribarren, Félix Gutiérrez, Alberto Terrón, Herminia Esteban, José Antonio Pérez-Molina
Background: Concerns have been voiced over the capacity of deintensification strategies to preserve neurocognitive function and prevent neurocognitive impairment. Methods: We present the 96 week results of a neurocognitive substudy nested within the SALT clinical trial: a randomized, open-label, non-inferiority trial that compares whether atazanavir/ritonavir + lamivudine is non-inferior to atazanavir/ritonavir + two NRTIs in HIV-suppressed patients on stable triple therapy...
June 11, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29889878/the-voice-study-a-before-and-after-study-of-a-dementia-communication-skills-training-course
#5
Rebecca O'Brien, Sarah E Goldberg, Alison Pilnick, Suzanne Beeke, Justine Schneider, Kate Sartain, Louise Thomson, Megan Murray, Bryn Baxendale, Rowan H Harwood
BACKGROUND: A quarter of acute hospital beds are occupied by persons living with dementia, many of whom have communication problems. Healthcare professionals lack confidence in dementia communication skills, but there are no evidence-based communication skills training approaches appropriate for professionals working in this context. We aimed to develop and pilot a dementia communication skills training course that was acceptable and useful to healthcare professionals, hospital patients and their relatives...
2018: PloS One
https://www.readbyqxmd.com/read/29889721/perspectives-on-patient-and-family-engagement-with-reduction-in-harm-the-forgotten-voice
#6
Elizabeth C Schenk, Ruth A Bryant, Catherine R Van Son, Tamara Odom-Maryon
BACKGROUND: Despite continued efforts to improve safety in hospitals, hospital-acquired harm persists. Strategies have been identified to establish patient-centered care and improve patient engagement with care. However, the relationship of patient and family engagement to reduction of harm is not well understood, with limited findings available in current literature. PURPOSE: This qualitative study explored the perceptions and attitudes of patients and family members and several clinical disciplines toward patient engagement in reducing preventable harm in hospitalized patients...
June 8, 2018: Journal of Nursing Care Quality
https://www.readbyqxmd.com/read/29884597/communication-about-geriatric-assessment-domains-in-advanced-cancer-settings-missed-opportunities
#7
Lisa M Lowenstein, Robert J Volk, Richard Street, Marie Flannery, Allison Magnuson, Ronald Epstein, Supriya G Mohile
OBJECTIVES: Older patients with advanced cancer often have age-related health issues (e.g., memory impairment) that influence their cancer treatment decisions. Communication about these age-related concerns can potentially lead to further assessment and subsequent clinical interventions to improve treatment decision-making and patients' quality of life. Yet, little is known about the communication of age-related concerns between oncologists, patients, and caregivers. MATERIALS AND METHODS: This study is a secondary analysis of data from the Values and Options in Cancer Care (VOICE) study...
June 5, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29881796/advocacy-for-children-with-epilepsy-leveraging-the-wha-resolution-advocacy-task-force-commission-of-pediatrics-international-league-against-epilepsy
#8
REVIEW
Jo M Wilmshurst, Alla Guekht, Mary Secco, J Helen Cross, Emilio Perucca
In May 2015 the World Health Assembly (WHA) approved the Resolution on the Global Burden of Epilepsy. This report addresses how the Resolution can be leveraged to improve the care of children with epilepsy worldwide. Children with epilepsy have unique needs and face unique challenges from stigma at all levels of society. Children lack a voice to lobby for their own needs, including their right to have access to education. Effective leadership and governance should be enhanced through the support of stakeholders empowered to counsel, advise, and lobby for appropriate care...
June 2018: Epilepsia Open
https://www.readbyqxmd.com/read/29880291/olaparib-combined-with-abiraterone-in-patients-with-metastatic-castration-resistant-prostate-cancer-a-randomised-double-blind-placebo-controlled-phase-2-trial
#9
Noel Clarke, Pawel Wiechno, Boris Alekseev, Nuria Sala, Robert Jones, Ivo Kocak, Vincenzo Emanuele Chiuri, Jacek Jassem, Aude Fléchon, Charles Redfern, Carsten Goessl, Joseph Burgents, Robert Kozarski, Darren Hodgson, Maria Learoyd, Fred Saad
BACKGROUND: Patients with metastatic castration-resistant prostate cancer and homologous recombination repair (HRR) mutations have a better response to treatment with the poly(ADP-ribose) polymerase inhibitor olaparib than patients without HRR mutations. Preclinical data suggest synergy between olaparib and androgen pathway inhibitors. We aimed to assess the efficacy of olaparib plus the androgen pathway inhibitor abiraterone in patients with metastatic castration-resistant prostate cancer regardless of HRR mutation status...
June 4, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29876333/pediatric-inflammatory-myofibroblastic-tumors-of-the-airway-two-case-reports-with-varying-clinical-presentation
#10
Nuthan Kumar, Thirunavukkarasu Saravanamuthu, Arathi Srinivasan, Thulasi Raman, Julius-Xavier Scott
Introduction: An inflammatory myofibroblastic tumor (IMT) is a rare tumor of intermediate malignant potential. It may occur in a wide range of anatomical locations. One-third are found in the respiratory tract. We report two cases of IMT of the airway diagnosed at our institution. Case Report: Case 1: A 6-year-old male child presented with a 1-month history of hoarseness of the voice. On evaluation, a polypoid nodule was noted in the right vocal cord which was excised through the endolaryngeal route...
May 2018: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29876327/patient-based-assessment-of-effectiveness-of-voice-therapy-in-vocal-mass-lesions-with-secondary-muscle-tension-dysphonia
#11
Ahmad Reza Khatoonabadi, Hassan Khoramshahi, Seyyedeh Maryam Khoddami, Payman Dabirmoghaddam, Noureddin Nakhostin Ansari
Introduction: Use of patient-based voice assessment scales is an appropriate method that is frequently used to demonstrate effectiveness of voice therapy. This study was aimed at determining the effectiveness of voice therapy among patients with secondary muscle tension dysphonia (MTD) and vocal mass lesions. Materials and Methods: The study design was prospective, with within-participant repeated measures. Thirty-three patients with secondary MTD and vocal mass lesions participated in the study, selected on the basis of voice history, laryngeal palpation, and videostroboscopy examination...
May 2018: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29875991/pneumorrhachis-after-recreational-drug-use
#12
Bilal A Sethi, Jamie G Cooper
Pneumorrhachis, the presence of air in the spinal canal, is an unusual and alarming radiographic finding. The etiology is most commonly traumatic or iatrogenic but it can occur as a spontaneous phenomenon in association with pneumomediastinum. We report the case of a 16 year old male who presented with throat discomfort and a feeling of altered voice after recreational drug use. Examination confirmed widespread subcutaneous emphysema above the clavicles and plain radiograph and computed tomography imaging confirmed the presence of extensive pneumomediastinum and pneumorrhachis...
April 2018: Journal of Radiology Case Reports
https://www.readbyqxmd.com/read/29867685/understanding-the-barriers-to-accessing-symptom-specific-cognitive-behavior-therapy-cbt-for-distressing-voices-reflecting-on-and-extending-the-lessons-learnt-from-the-cbt-for-psychosis-literature
#13
Cassie M Hazell, Kathryn Greenwood, Sarah Fielding-Smith, Aikaterini Rammou, Leanne Bogen-Johnston, Clio Berry, Anna-Marie Jones, Mark Hayward
The experience of hearing voices ('auditory hallucinations') can cause significant distress and disruption to quality of life for people with a psychosis diagnosis. Psychological therapy in the form of cognitive behavior therapy (CBT) for psychosis is recommended for the treatment of positive symptoms, including distressing voices, but is rarely available to patients in the United Kingdom. CBT for psychosis has recently evolved with the development of symptom-specific therapies that focus upon only one symptom of psychosis at a time...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29862740/-design-of-multifunctional-automated-external-defibrillator-based-on-stm32
#14
Kewu Wang, Shengxiang Xiao, Yongtao Ji, Yuqiu Fang
This paper presents a design of multifunctional portable automated external defibrillator based on STM32F103VC SCM. The defibrillator mainly realizes the defibrillation and ECG analysis function, and according to the clinical actual need, increases information storage and transmission function, query of local records, the function of synchronous LCD display and voice prompt in the defibrillation process. The device uses the defibrillating electrodes to measure body resistance, ECG and so on. We detailedly researched and achieved the discharge module of biphasic defibrillation apparatus based on the damping of two order discharge circuit, and finished the real-time LCD display and voice prompt modules of defibrillation information based on the control of PIC24FJ256DA210 chip...
January 30, 2018: Zhongguo Yi Liao Qi Xie za Zhi, Chinese Journal of Medical Instrumentation
https://www.readbyqxmd.com/read/29859267/rationale-and-design-of-the-tele-exercise-and-multiple-sclerosis-teams-study-a-comparative-effectiveness-trial-between-a-clinic-and-home-based-telerehabilitation-intervention-for-adults-with-multiple-sclerosis-ms-living-in-the-deep-south
#15
James H Rimmer, Mohanraj Thirumalai, Hui-Ju Young, Dori Pekmezi, Tracy Tracy, Emily Riser, Tapan Mehta
Long-term exercise/rehabilitation is an integral component of the continual care for people with multiple sclerosis (MS). However, access to this care, which includes comprehensive exercise/rehabilitation services to people with MS, remains a significant challenge, especially in rural, low-income areas. Telerehabilitation, or what we refer to as teleexercise, can help fill service gaps for underserved MS populations in this region. This pragmatic, cluster randomized controlled effectiveness trial will compare a 12-week, 20 session complementary and alternative medicine (CAM) intervention composed of neurorehabilitative (functional) exercise, yoga and Pilates delivered at home, using pre-loaded tablets and Interactive Voice Response (IVR) system technology (TeleCAM), to the same intervention delivered in clinic by a therapist (DirectCAM)...
May 30, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29849504/-heart-health-whispering-a-randomized-controlled-pilot-study-to-promote-nursing-student-perspective-taking-on-carers-health-risk-behaviors
#16
Michelle Lobchuk, Lisa Hoplock, Gayle Halas, Christina West, Cheryl Dika, Wilma Schroeder, Terri Ashcroft, Kathleen Chambers Clouston, Jocelyne Lemoine
Background: Lifestyle counseling is described as a "major breakthrough" in the control of chronic diseases. Counseling can be challenging to nurses due their lack of motivation to counsel, hesitancy to appear non-judgmental, lack of empathy, and lack of time. Nurses voice their need for more training in counseling communication skills. Our main objective was to engage in ongoing development and testing of a promising Heart Health Whispering perspective-taking intervention on nursing students' clinical empathy, perceptual understanding, and client readiness to alter health risk behaviors...
2018: BMC Nursing
https://www.readbyqxmd.com/read/29848192/principles-of-patient-and-public-involvement-in-primary-care-research-applied-to-mental-health-research-a-keynote-paper-from-the-egprn-autumn-conference-2017-in-dublin
#17
Amanda Howe
Clinical research relies on patients being willing to participate in research projects, and making this possible for patients with mental health problems can be a particular challenge. In the modern era, many countries have seen a movement to give a stronger voice to patients both in choices around their care and in how research is conducted. How to achieve effective patient and public involvement (PPI) and to make the patients real partners in this effort is itself a subject of research evaluation. This opinion piece-based on a keynote lecture given at the European General Practice Research Network 2017 autumn meeting in Dublin-describes both the reasons for expanding PPI, how it can usefully be achieved, and how this may relate to the particular context of mental health...
December 2018: European Journal of General Practice
https://www.readbyqxmd.com/read/29844796/phase-iv-study-of-retention-on-fingolimod-versus-injectable-multiple-sclerosis-therapies-a-randomized-clinical-trial
#18
Bruce A C Cree, Douglas L Arnold, Mark Cascione, Edward J Fox, Ian M Williams, Xiangyi Meng, Lesley Schofield, Nadia Tenenbaum
Objective: In relapsing-remitting multiple sclerosis (RRMS), suboptimal adherence to injectable disease-modifying therapies (iDMTs; interferon β-1a/b, glatiramer acetate) is common, reducing their effectiveness. Patient retention on oral fingolimod and iDMTs was evaluated in PREFER MS , a randomized, parallel-group, active-controlled, open-label, 48-week study. Methods: Patients were included if they had RRMS, were aged 18-65 years and had Expanded Disability Status Scale score up to 6, enrolled at 117 US study sites, were treatment naïve or had received only one iDMT class...
2018: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/29842828/motivations-of-south-african-physicians-specialising-in-public-health
#19
Virginia Elizabeth Melvill Zweigenthal, William M Pick, Leslie London
BACKGROUND: South African physicians can specialise in public health through a four-year 'registrar' programme. Despite national health policies that seemingly value public health (PH) approaches, the Public Health Medicine (PHM) speciality is largely invisible in the health services. Nevertheless, many physicians enrol for specialist training. OBJECTIVES: This study investigated physicians' motivations for specialising in PHM, their intended career paths, perceptions of training, and perspectives about the future of the speciality...
2018: Global Health Action
https://www.readbyqxmd.com/read/29809039/implementation-of-evidence-based-practices-for-complex-mood-disorders-in-primary-care-safety-net-clinics
#20
John C Fortney, Jeffrey M Pyne, Susan Ward-Jones, Ian M Bennett, Joan Diehl, Kellee Farris, Joseph M Cerimele, Geoffrey M Curran
INTRODUCTION: Use quality improvement methods to implement evidence-based practices for bipolar depression and treatment-resistant depression in 6 Federally Qualified Health Centers. METHOD: Following qualitative needs assessments, implementation teams comprised of front-line providers, patients, and content experts identified, adapted, and adopted evidence-based practices. With external facilitation, onsite clinical champions led the deployment of the evidence-based practices...
May 28, 2018: Families, Systems & Health: the Journal of Collaborative Family Healthcare
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