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Dysphonia

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https://www.readbyqxmd.com/read/28434284/injection-of-basic-fibroblast-growth-factor-for-unilateral-vocal-cord-paralysis
#1
Takeharu Kanazawa, Kazuya Kurakami, Kazutaka Kashima, Ujimoto Konomi, Daigo Komazawa, Kazuhiro Nakamura, Koji Matsushima, Yusuke Akagi, Kiyoshi Misawa, Hiroshi Nishino, Yusuke Watanabe
OBJECTIVE: Unilateral vocal cord paralysis (UVCP) not only induces severe dysphonia, but aspiration as well. Although laryngeal framework surgery is usually performed to treat this condition, the procedure is not tolerated by some patients. In the previous study, basic fibroblast growth factor (bFGF) injections for vocal cord scarring and sulcus have been reported to provide favorable outcomes while being minimally invasive. In this study, the authors retrospectively investigated phonological outcomes after bFGF injection in patients with UVCP...
April 22, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28416083/prevalence-and-occupation-of-patients-presenting-with-dysphonia-in-the-united-states
#2
Michael S Benninger, Chantal E Holy, Paul C Bryson, Claudio F Milstein
OBJECTIVE: Voice disorders are common conditions that may have a significant impact on patient quality of life, yet their prevalence and epidemiology are poorly documented. In this study, we estimated the prevalence, demographics, and occupation of patients with dysphonia. METHODS: Using the Commercial and Medicare MarketScan databases of 146.7 million lives (2008-2012), the prevalence of dysphonia was estimated. Patient demographics and industry occupation were evaluated...
April 13, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28414781/voice-disorder-in-systemic-lupus-erythematosus
#3
Milena S F C de Macedo, Kauê M Costa, Manoel da Silva Filho
Systemic lupus erythematosus (SLE) is a chronic disease characterized by progressive tissue damage. In recent decades, novel treatments have greatly extended the life span of SLE patients. This creates a high demand for identifying the overarching symptoms associated with SLE and developing therapies that improve their life quality under chronic care. We hypothesized that SLE patients would present dysphonic symptoms. Given that voice disorders can reduce life quality, identifying a potential SLE-related dysphonia could be relevant for the appraisal and management of this disease...
2017: PloS One
https://www.readbyqxmd.com/read/28412598/effect-of-two-isolated-vocal-facilitating-techniques-glottal-fry-and-yawn-sigh-on-the-phonation-of-female-speech-language-pathology-students-a-pilot-study
#4
I Meerschman, E D'haeseleer, T Catry, B Ruigrok, S Claeys, K Van Lierde
OBJECTIVE: The purpose of this study was to determine the effect of two isolated vocal facilitating techniques, glottal fry and yawn-sigh, on the phonation of vocally healthy female speech-language pathology (SLP) students. STUDY DESIGN: A multigroup pretest-posttest design was used. METHODS: A group of thirty-six healthy female SLP students with a mean age of 18.1 years were assigned into three groups: a glottal fry group (practicing the facilitating technique glottal fry across 18 weeks, n=12), a yawn-sigh group (practicing the facilitating technique yawn-sigh across 18 weeks, n=12) and a control group (receiving no facilitating techniques, n=12)...
March 27, 2017: Journal of Communication Disorders
https://www.readbyqxmd.com/read/28410773/brain-activity-during-phonation-in-women-with-muscle-tension-dysphonia-an-fmri-study
#5
Maryna Kryshtopava, Kristiane Van Lierde, Iris Meerschman, Evelien D'Haeseleer, Pieter Vandemaele, Guy Vingerhoets, Sofie Claeys
OBJECTIVES: The main objectives of this functional magnetic resonance imaging (fMRI) study are (1) to investigate brain activity during phonation in women with muscle tension dysphonia (MTD) in comparison with healthy controls; and (2) to explain the neurophysiological mechanism of laryngeal hyperfunction/tension during phonation in patients with MTD. METHODS: Ten women with MTD and fifteen healthy women participated in this study. The fMRI experiment was carried out using a block design paradigm...
April 11, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28407759/a-new-clinical-algorithm-scoring-for-management-of-suspected-foreign-body-aspiration-in-children
#6
Ibrahim A Janahi, Shabina Khan, Prem Chandra, Noora Al-Marri, Ammar Saadoon, Lolwa Al-Naimi, Maryam Al-Thani, William Greer
BACKGROUND: Foreign Body Aspiration (FBA) is a serious problem in children and delays in diagnosis and management can be devastating. The history is often vague, with subtle physical and chest radiograph abnormalities. This study aims to determine the indications for bronchoscopy in children with suspected FBA and evaluate the key clinical and statistically significant predictors of FBA, based on the patients' historical, physical and radiological findings at presentation. METHODS: This is a retrospective observational study, including patients who were admitted between January 2001 to January 2011 with suspected FBA...
April 13, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28403100/delayed-bilateral-vocal-cord-paresis-after-a-continuous-interscalene-brachial-plexus-block-and-endotracheal-intubation-a-lesson-why-we-should-use-low-concentrated-local-anesthetics-for-continuous-blocks
#7
Hee-Sun Park, Ha-Jung Kim, Young-Jin Ro, Hong-Seuk Yang, Won-Uk Koh
RATIONALE: Recurrent laryngeal nerve block is an uncommon complication that can occur after an interscalene brachial plexus block (ISB), which may lead to vocal cord palsy or paresis. However, if the recurrent laryngeal nerve is blocked in patients with a preexisting contralateral vocal cord palsy following neck surgery, this may lead to devastating acute respiratory failure. Thus, ISB is contraindicated in patients with contralateral vocal cord lesion. To the best of our knowledge, there are no reports of bilateral vocal cord paresis, which occurred after a continuous ISB and endotracheal intubation in a patient with no history of vocal cord injury or surgery of the neck...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28402988/incidence-and-factors-predictive-of-dysphagia-and-dysphonia-after-anterior-operation-with-multilevel-cervical-spondylotic-myelopathy
#8
Shunzhi Yu, Zhi Chen, Ning Yan, Tiesheng Hou, Shisheng He
STUDY DESIGN: Retrospective database analysis. OBJECTIVE OF THE STUDY: The objective of the study was to quantify the incidence of dysphagia and dysphonia and assess the associated risk factors after multilevel cervical anterior operation. SUMMARY OF BACKGROUND DATA: Anterior approach for multilevel cervical spondylotic myelopathy has been developed and obtained favorable outcomes. As number of fused levels increased, the operation difficulty, invasiveness and operative risks are higher...
April 11, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28397560/herpes-simplex-virus-laryngitis-presenting-as-airway-obstruction-a-case-report-and-literature-review
#9
Lucas Harless, Nancy Jiang, Frank Schneider, Megan Durr
OBJECTIVES: Herpes simplex virus (HSV) laryngitis is rare in adults. We add a case report to the literature and perform a literature review to further delineate the clinical presentation, course, and treatment of HSV laryngitis in adults. METHODS: Case report and literature review using PubMed and Ovid databases. RESULTS: Ten cases of diagnosed HSV laryngitis in adults were reported in the literature. It is more common in immunocompromised patients...
May 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28397557/factors-associated-with-infectious-laryngitis-a-retrospective-review-of-15-cases
#10
Carissa M Thomas, Marie E Jetté, Matthew S Clary
OBJECTIVES: To identify the culturable microbes associated with infectious laryngitis and outline effective treatment strategies. METHODS: This is a retrospective chart review of adult patients with persistent dysphonia plus evidence of laryngeal inflammation who underwent biopsy for culture at a tertiary care medical center. Demographic factors, symptoms as reported on validated patient assessment tools, past medical history, social history, culture results, and treatment duration and response were reviewed...
May 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28396220/does-even-low-grade-dysphonia-warrant-voice-center-referral
#11
Resha S Soni, Barbara Ebersole, Nausheen Jamal
OBJECTIVE: Data regarding the referral of dysphonic patients to specialty voice clinics are limited. The objective of this study is to examine the relationship between low perceptual dysphonia severity and subtle laryngeal findings to discern if this can help guide referral. STUDY DESIGN: This is a retrospective chart review. METHODS: The charts of 94 patients presenting with a primary complaint of hoarseness to a single laryngologist over a 1-year period at a tertiary care, interdisciplinary voice center were analyzed...
April 7, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28392086/correlation-of-iranian-voice-quality-of-life-profile-ivqlp-to-vhi-30-and-vrqol-construct-validity-evidence
#12
Ali Dehqan, Ronald C Scherer, Fariba Yadegari
OBJECTIVES: An important domain in health-related quality of life evaluations is quality of life perceptions due to having a voice disorder. The purpose of the current study was (1) to examine the correlation of the Iranian Voice Quality of Life Profile (IVQLP) with the Voice-Related Quality of Life (VRQOL) and Voice Handicap Index-30 (VHI-30) for establishing the construct convergent validity of the IVQLP, and (2) to examine the correlation between VRQOL and VHI-30. METHODS: Study sample consisted of 150 patients, 91 male and 59 female, diagnosed with muscle tension dysphonia, benign organic disorders such as polyps and nodules, and unilateral vocal fold paralysis...
April 6, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28390606/reliability-and-validity-of-the-dutch-pediatric-voice-handicap-index
#13
Laura Veder, Bas Pullens, Marieke Timmerman, Hans Hoeve, Koen Joosten, Marieke Hakkesteegt
INTRODUCTION: The pediatric voice handicap index (pVHI) has been developed to provide a better insight into the parents' perception of their child's voice related quality of life. The purpose of the present study was to validate the Dutch pVHI by evaluating its internal consistency and reliability. Furthermore, we determined the optimal cut-off point for a normal pVHI score. METHODS: All items of the English pVHI were translated into Dutch. Parents of children in our dysphonic and control group were asked to fill out the questionnaire...
May 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28376853/a-large-giant-cell-tumor-of-the-larynx-case-report-and-review-of-the-literature
#14
Andrew Arndt, Rachelle LeBlanc, Peter Spafford
BACKGROUND: Giant cell tumors (GCTs) are typically found in the metaphyseal-epiphyseal area of long bones but can also occur in the head and neck region. GCT of the larynx is a rare entity with only 42 reported cases in the international literature. Furthermore, to the best of our knowledge this is the largest laryngeal GCT reported in the literature to date. GCT of the larynx can present with dysphonia, dyspnea, and/or dysphagia and should be considered in the differential diagnosis of a neck mass...
April 4, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28373007/avelumab-for-metastatic-or-locally-advanced-previously-treated-solid-tumours-javelin-solid-tumor-a-phase-1a-multicohort-dose-escalation-trial
#15
Christopher R Heery, Geraldine O'Sullivan-Coyne, Ravi A Madan, Lisa Cordes, Arun Rajan, Myrna Rauckhorst, Elizabeth Lamping, Israel Oyelakin, Jennifer L Marté, Lauren M Lepone, Renee N Donahue, Italia Grenga, Jean-Marie Cuillerot, Berend Neuteboom, Anja von Heydebreck, Kevin Chin, Jeffrey Schlom, James L Gulley
BACKGROUND: Avelumab (MSB0010718C) is a human IgG1 monoclonal antibody that binds to PD-L1, inhibiting its binding to PD-1, which inactivates T cells. We aimed to establish the safety and pharmacokinetics of avelumab in patients with solid tumours while assessing biological correlatives for future development. METHODS: This open-label, single-centre, phase 1a, dose-escalation trial (part of the JAVELIN Solid Tumor trial) assessed four doses of avelumab (1 mg/kg, 3 mg/kg, 10 mg/kg, and 20 mg/kg), with dose-level cohort expansions to provide additional safety, pharmacokinetics, and target occupancy data...
March 31, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28366109/reflections-the-value-of-patient-support-groups
#16
Amanda Hu
A patient support group is defined as "a group of people with common experiences and concerns who provide emotional and moral support for one another." Support groups fulfill many functions: educating patients/family, sharing the illness experience, providing strength to its members, raising public awareness, and fundraising. Some research has shown an improvement in quality of life of patients with head and neck cancer who have participated in support groups. A wide variety of support groups are available for otolaryngology patients, ranging from head and neck oncology to tinnitus and spasmodic dysphonia...
April 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28357083/primary-laryngeal-localization-of-multiple-myeloma-a-case-report
#17
Eugenia Allegra, Nicolò Marino, Domenico Modica, Carmela Emmanuele, Vincenzo Saita
Multiple myeloma is a lymphoproliferative disease that may involve the bone marrow as well as extramedullary soft tissues. However, laryngeal localization of multiple myeloma is extremely rare. We herein present the case of a 68-year-old male patient with a history of dyspnea, dysphonia and dysphagia. Laryngoscopic examination revealed a lesion involving the right glottis and right vestibular (false) vocal fold, with absence of ipsilateral laryngeal motility and constriction of the airway. Computed tomography and magnetic resonance imaging revealed a gross swelling infiltrating the right glottis and right false vocal fold, sized 33×19×33 mm, with sub-centimeter laterocervical lymph nodes bilaterally...
February 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28356124/denosumab-treatment-for-progressive-skull-base-giant-cell-tumor-of-bone-in-a-14%C3%A2-year-old-female-a-case-report-and-literature-review
#18
Samvel Bardakhchyan, Leo Kager, Samvel Danielyan, Armen Avagyan, Nerses Karamyan, Hovhannes Vardevanyan, Sergey Mkhitaryan, Ruzanna Papyan, Davit Zohrabyan, Liana Safaryan, Lilit Sargsyan, Lilit Harutyunyan, Lusine Hakobyan, Samvel Iskanyan, Gevorg Tamamyan
BACKGROUND: Giant cell tumor of bone (GCT) is a rare primary bone tumor, which can metastasize and undergo malignant transformation. The standard treatment of GCT is surgery. In patients with unresectable or metastatic disease, additional therapeutic options are available. These include blocking of the receptor activator of NF-kappa B ligand (RANKL) signaling pathway, which plays a role in the pathogenesis of GCT of bone, via the anti-RANKL monoclonal antibody denosumab. CASE PRESENTATION: Herein we report on a female teenager who presented in a very poor clinical condition (cachexia, diplopia, strabismus, dysphonia with palsy of cranial nerves V, VI, VIII, IX, X, XI and XII) due to progressive disease, after incomplete resection and adjuvant radiotherapy, of a GCT which affected the cervical spine (C1 and C2) as well as the skull base; and who had an impressive clinical response to denosumab therapy...
March 29, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28345678/laryngeal-manual-therapy-palpatory-evaluation-scale-a-preliminary-study-to-examine-its-usefulness-in-diagnosis-of-occupational-dysphonia
#19
Ewelina Woźnicka, Ewa Niebudek-Bogusz, Joanna Morawska, Justyna Wiktorowicz, Mariola Śliwińska-Kowalska
BACKGROUND: The aim of this study has been to assess the larynx and soft tissue around the vocal tract in a group of people with healthy voice, and in a group of patients with occupational dysphonia using the new laryngeal manual therapy palpatory evaluation scale (LMTPE). MATERIAL AND METHODS: The examinations were performed in a study (dysphonic) group of professional voice users who had developed voice disorders (N = 51) and in the control group of normophonic subjects (N = 50)...
March 24, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28342677/prevalence-of-voice-disorders-in-singers-systematic-review-and-meta-analysis
#20
Pedro Melo Pestana, Susana Vaz-Freitas, Maria Conceição Manso
OBJECTIVE: The study aimed to review the prevalence of self-reported voice disorders in singers. STUDY DESIGN: The study is a systematic review and meta-analysis. METHODS: A systematic review of five major scientific databases was conducted. An extensive search strategy was used considering the rules of each database. Original articles were included only if they had data related to self-perception of dysphonia in the past. Furthermore, heterogeneity and its relative significance were assessed...
March 22, 2017: Journal of Voice: Official Journal of the Voice Foundation
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