keyword
https://read.qxmd.com/read/36653238/interobserver-agreement-in-the-histopathological-classification-of-desmoplastic-melanomas
#21
JOURNAL ARTICLE
Cecilia Lezcano, Marianne Berwick, Li Luo, Raymond Barnhill, Lyn M Duncan, Pedram Gerami, Lori Lowe, Jane L Messina, Richard A Scolyer, Benjamin Wood, Iwei Yeh, Artur Zembowicz, Klaus J Busam
Desmoplastic melanoma is a subtype of melanoma characterised by amelanotic fusiform melanocytes dispersed in a collagenous stroma. Cell-poor and fibrous stroma-rich 'pure' variants have been distinguished from 'mixed' variants with areas of higher cell density and/or less desmoplastic stroma. This distinction is relevant because patients whose tumours display a pure phenotype have a lower risk for regional lymph node metastasis and distant recurrence. However, little is known about interobserver agreement among pathologists in the subclassification of desmoplastic melanoma...
January 2, 2023: Pathology
https://read.qxmd.com/read/36630628/constancy-of-purpose-for-improving-patient-safety-missing-in-action
#22
EDITORIAL
Donald M Berwick
New England Journal of Medicine, Volume 388, Issue 2, Page 181-182, January 2023.
January 12, 2023: New England Journal of Medicine
https://read.qxmd.com/read/36516087/mandatory-reporting-of-emissions-to-achieve-net-zero-health-care
#23
JOURNAL ARTICLE
Hardeep Singh, Matthew Eckelman, Donald M Berwick, Jodi D Sherman
New England Journal of Medicine, Volume 387, Issue 26, Page 2469-2476, December 2022.
December 14, 2022: New England Journal of Medicine
https://read.qxmd.com/read/36480947/-values-to-value-for-recovery-and-renewal-prudent-healthcare-the-key-to-transforming-the-health-and-care-system
#24
JOURNAL ARTICLE
Paul Buss, Helen Howson, Claire O'Neill, Don Berwick
No abstract text is available yet for this article.
December 2022: Journal of the Royal Society of Medicine
https://read.qxmd.com/read/36445228/the-reversal-characteristics-of-gabaergic-neurons-a-neurovascular-model
#25
JOURNAL ARTICLE
Tim David, Robin Morillo, Clare Howarth, Jason Berwick, Llywelyn Lee
Neurovascular coupling (NVC) is the ability to locally adjust vascular resistance as a function of neuronal activity. Recent experiments have illustrated that NVC is partially independent of metabiolic signals. In addition Nitric Oxide (NO) has been shown in some instances to provide an important mechanism in altering vascular resistance. An extension to the original model of NVC [1] has been developed to include the activation of both somato-sensory neurons and GABAergic interneurons and to investigate the role of NO and the delicate balance of GABA and neuronal peptide enzymes (NPY) pathways...
November 29, 2022: Journal of Biomechanical Engineering
https://read.qxmd.com/read/36427885/the-diagnosis-of-fibromyalgia-syndrome
#26
JOURNAL ARTICLE
Richard Berwick, Chris Barker, Andreas Goebel
Fibromyalgia syndrome (FMS) is a common widespread primary pain condition, with a worldwide prevalence of 2%-4%. Recent research has revealed important evidence for changes in central and peripheral nervous system functions and immunological activity. The diagnosis of FMS can be challenging with no known clinical laboratory investigations to confirm or refute its presence. Symptoms are commonly multiple, fluctuant and may not easily align with established medical diagnostic categories. It can be difficult for patients to articulate their array of symptoms, and for both patients and healthcare professionals to fully make sense of the complexities of the condition...
November 2022: Clinical Medicine: Journal of the Royal College of Physicians of London
https://read.qxmd.com/read/36409483/medicare-2-0-a-vision-for-the-future-of-america-s-health-insurance-plan
#27
JOURNAL ARTICLE
Micah Johnson, Donald M Berwick
No abstract text is available yet for this article.
November 21, 2022: JAMA
https://read.qxmd.com/read/36288369/applying-lead-pb-isotopes-to-explore-mobility-in-humans-and-animals
#28
JOURNAL ARTICLE
Jane A Evans, Vanessa Pashley, Katy Mee, Doris Wagner, Mike Parker Pearson, Delphine Fremondeau, Umberto Albarella, Richard Madgwick
Lead (Pb) isotopes provide a complementary method to other provenance tools for tracking the origin and movement of humans and animals. The method is founded in the geographic distribution of Pb isotope ratios. However, unlike the Sr isotope method that is closely linked to the lithology of underlying rocks, Pb more closely reflects the tectonic regimes. This makes it particularly pertinent to use in Britain as there is major tectonic boundary (the Iapetus Suture) that runs between Berwick-upon-Tweed and the Solway Firth providing a compositional boundary in Pb isotope domains that approximates to the geographic areas of Scotland versus England and Wales...
2022: PloS One
https://read.qxmd.com/read/36170522/leading-improvement-at-scale-in-healthcare-sir-john-oldham
#29
EDITORIAL
John Oldham
BACKGROUND: When I became senior partner at my general practice I undertook a part time MBA at Manchester Business School in the late 90s to learn the things medical school hadn't taught me; organizational design and behaviour, finance, strategic management and human resources (as it was then called). My dissertation was on quality methods in other industries that could be applied in healthcare. JOURNEY: We tried out total quality management methods in my practice and began to demonstrably improve care, services and the use of resources...
June 2022: BMJ leader
https://read.qxmd.com/read/36125018/computer-clinical-decision-support-that-automates-personalized-clinical-care-a-challenging-but-needed-healthcare-delivery-strategy
#30
JOURNAL ARTICLE
Alan H Morris, Christopher Horvat, Brian Stagg, David W Grainger, Michael Lanspa, James Orme, Terry P Clemmer, Lindell K Weaver, Frank O Thomas, Colin K Grissom, Ellie Hirshberg, Thomas D East, Carrie Jane Wallace, Michael P Young, Dean F Sittig, Mary Suchyta, James E Pearl, Antinio Pesenti, Michela Bombino, Eduardo Beck, Katherine A Sward, Charlene Weir, Shobha Phansalkar, Gordon R Bernard, B Taylor Thompson, Roy Brower, Jonathon Truwit, Jay Steingrub, R Duncan Hiten, Douglas F Willson, Jerry J Zimmerman, Vinay Nadkarni, Adrienne G Randolph, Martha A Q Curley, Christopher J L Newth, Jacques Lacroix, Michael S D Agus, Kang Hoe Lee, Bennett P deBoisblanc, Frederick Alan Moore, R Scott Evans, Dean K Sorenson, Anthony Wong, Michael V Boland, Willard H Dere, Alan Crandall, Julio Facelli, Stanley M Huff, Peter J Haug, Ulrike Pielmeier, Stephen E Rees, Dan S Karbing, Steen Andreassen, Eddy Fan, Roberta M Goldring, Kenneth I Berger, Beno W Oppenheimer, E Wesley Ely, Brian W Pickering, David A Schoenfeld, Irena Tocino, Russell S Gonnering, Peter J Pronovost, Lucy A Savitz, Didier Dreyfuss, Arthur S Slutsky, James D Crapo, Michael R Pinsky, Brent James, Donald M Berwick
How to deliver best care in various clinical settings remains a vexing problem. All pertinent healthcare-related questions have not, cannot, and will not be addressable with costly time- and resource-consuming controlled clinical trials. At present, evidence-based guidelines can address only a small fraction of the types of care that clinicians deliver. Furthermore, underserved areas rarely can access state-of-the-art evidence-based guidelines in real-time, and often lack the wherewithal to implement advanced guidelines...
September 19, 2022: Journal of the American Medical Informatics Association: JAMIA
https://read.qxmd.com/read/35897629/formation-of-gold-nanoparticle-self-assembling-films-in-various-polymer-matrices-for-sers-substrates
#31
JOURNAL ARTICLE
Ksenia A Maleeva, Ilia E Kaliya, Anton P Tkach, Anton A Babaev, Michail A Baranov, Kevin Berwick, Tatiana S Perova, Alexander V Baranov, Kirill V Bogdanov
Surface-enhanced Raman spectroscopy (SERS) is regarded as a versatile tool for studying the composition and structure of matter. This work has studied the preparation of a SERS substrate based on a self-assembling plasmonic nanoparticle film (SPF) in a polymer matrix. Several synthesis parameters for the SPF are investigated, including the size of the particles making up the film and the concentration and type of the self-assembling agent. The result of testing systems with different characteristics is discussed using a model substance (pseudoisocyanin iodide)...
July 27, 2022: Materials
https://read.qxmd.com/read/35876628/landscape-of-mutations-in-early-stage-primary-cutaneous-melanoma-an-intermel-study
#32
JOURNAL ARTICLE
Li Luo, Ronglai Shen, Arshi Arora, Irene Orlow, Klaus J Busam, Cecilia Lezcano, Tim K Lee, Eva Hernando, Ivan Gorlov, Christopher Amos, Marc S Ernstoff, Venkatraman E Seshan, Anne E Cust, James Wilmott, Richard A Scolyer, Graham Mann, Eduardo Nagore, Pauline Funchain, Jennifer Ko, Peter Ngo, Sharon N Edmiston, Kathleen Conway, Paul B Googe, David Ollila, Jeffrey E Lee, Shenying Fang, Judy R Rees, Cheryl L Thompson, Meg Gerstenblith, Marcus Bosenberg, Bonnie Gould Rothberg, Iman Osman, Yvonne Saenger, Adam Z Reynolds, Matthew Schwartz, Tawny Boyce, Sheri Holmen, Elise Brunsgaard, Paul Bogner, Pei Fen Kuan, Charles Wiggins, Nancy E Thomas, Colin B Begg, Marianne Berwick
It is unclear why some melanomas aggressively metastasize while others remain indolent. Available studies employing multi-omic profiling of melanomas are based on large primary or metastatic tumors. We examine the genomic landscape of early-stage melanomas diagnosed prior to the modern era of immunological treatments. Untreated cases with Stage II/III cutaneous melanoma were identified from institutions throughout the United States, Australia and Spain. FFPE tumor sections were profiled for mutation, methylation and microRNAs...
July 25, 2022: Pigment Cell & Melanoma Research
https://read.qxmd.com/read/35849383/addressing-well-being-throughout-the-health-care-workforce-the-next-imperative
#33
JOURNAL ARTICLE
Lisa S Rotenstein, Donald M Berwick, Christine K Cassel
No abstract text is available yet for this article.
July 18, 2022: JAMA
https://read.qxmd.com/read/35652761/after-sensations-and-lingering-pain-following-examination-in-patients-with-fibromyalgia-syndrome
#34
JOURNAL ARTICLE
Richard J Berwick, David A Andersson, Andreas Goebel, Andrew Marshall
Fibromyalgia syndrome (FMS) is a chronic widespread pain condition with mixed peripheral and central contributions. Patients display hypersensitivities to a spectrum of stimuli. Patients' blunt pressure pain thresholds are typically reduced, and sometimes (∼15%) gentle brushstroke induces allodynia. However, after-sensations following these stimuli have not, to our knowledge, been reported. We examined the perception of blunt pressure and 'pleasant touch' in FMS. Patients were first interviewed and completed standard psychometric questionnaires...
June 2, 2022: Pain Medicine
https://read.qxmd.com/read/35482356/getting-serious-about-producing-health-the-ten-teams-challenge
#35
JOURNAL ARTICLE
Donald M Berwick
No abstract text is available yet for this article.
May 17, 2022: JAMA
https://read.qxmd.com/read/35480113/-in-vivo-mirna-decoy-screen-reveals-mir-124a-as-a-suppressor-of-melanoma-metastasis
#36
JOURNAL ARTICLE
Rana S Moubarak, Lisa Koetz-Ploch, Gavriel Mullokandov, Avital Gaziel, Ana de Pablos-Aragoneses, Diana Argibay, Kevin Kleffman, Elena Sokolova, Marianne Berwick, Nancy E Thomas, Iman Osman, Brian D Brown, Eva Hernando
Melanoma is a highly prevalent cancer with an increasing incidence worldwide and high metastatic potential. Brain metastasis is a major complication of the disease, as more than 50% of metastatic melanoma patients eventually develop intracranial disease. MicroRNAs (miRNAs) have been found to play an important role in the tumorigenicity of different cancers and have potential as markers of disease outcome. Identification of relevant miRNAs has generally stemmed from miRNA profiling studies of cells or tissues, but these approaches may have missed miRNAs with relevant functions that are expressed in subfractions of cancer cells...
2022: Frontiers in Oncology
https://read.qxmd.com/read/35442387/differentiating-between-lead-time-bias-and-true-survival-benefits-when-discussing-racial-and-ethnic-disparities-in-melanoma
#37
COMMENT
Avani M Kolla, Marianne Berwick, David Polsky
No abstract text is available yet for this article.
June 1, 2022: JAMA Dermatology
https://read.qxmd.com/read/35422473/the-effects-of-locomotion-on-sensory-evoked-haemodynamic-responses-in-the-cortex-of-awake-mice
#38
JOURNAL ARTICLE
Beth Eyre, Kira Shaw, Paul Sharp, Luke Boorman, Llywelyn Lee, Osman Shabir, Jason Berwick, Clare Howarth
Investigating neurovascular coupling in awake rodents is becoming ever more popular due, in part, to our increasing knowledge of the profound impacts that anaesthesia can have upon brain physiology. Although awake imaging brings with it many advantages, we still do not fully understand how voluntary locomotion during imaging affects sensory-evoked haemodynamic responses. In this study we investigated how evoked haemodynamic responses can be affected by the amount and timing of locomotion. Using an awake imaging set up, we used 2D-Optical Imaging Spectroscopy (2D-OIS) to measure changes in cerebral haemodynamics within the sensory cortex of the brain during either 2 s whisker stimulation or spontaneous (no whisker stimulation) experiments, whilst animals could walk on a spherical treadmill...
April 14, 2022: Scientific Reports
https://read.qxmd.com/read/35103760/improving-traumatic-brain-injury-care-and-research-a-report-from-the-national-academies-of-sciences-engineering-and-medicine
#39
JOURNAL ARTICLE
Katherine Bowman, Chanel Matney, Donald M Berwick
No abstract text is available yet for this article.
February 1, 2022: JAMA
https://read.qxmd.com/read/35014950/assessment-of-neurovascular-coupling-and-cortical-spreading-depression-in-mixed-mouse-models-of-atherosclerosis-and-alzheimer-s-disease
#40
JOURNAL ARTICLE
Osman Shabir, Ben Pendry, Llywelyn Lee, Beth Eyre, Paul S Sharp, Monica A Rebollar, David Drew, Clare Howarth, Paul R Heath, Stephen B Wharton, Sheila E Francis, Jason Berwick
Neurovascular coupling is a critical brain mechanism whereby changes to blood flow accompany localised neural activity. The breakdown of neurovascular coupling is linked to the development and progression of several neurological conditions including dementia. In this study, we examined cortical haemodynamics in mouse preparations that modelled Alzheimer's disease (J20-AD) and atherosclerosis (PCSK9-ATH) between 9 and 12 m of age. We report novel findings with atherosclerosis where neurovascular decline is characterised by significantly reduced blood volume, altered levels of oxyhaemoglobin and deoxyhaemoglobin, in addition to global neuroinflammation...
January 11, 2022: ELife
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