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https://www.readbyqxmd.com/read/27924449/translation-and-adaptation-of-skin-cancer-genomic-risk-education-materials-for-implementation-in-primary-care
#1
Vivian M Rodríguez, Erika Robers, Kate Zielaskowski, C Javier González, Keith Hunley, Kimberly A Kaphingst, Dolores D Guest, Andrew Sussman, Kirsten A Meyer White, Matthew R Schwartz, Jennie Greb, Yvonne Talamantes, Jessica Bigney, Marianne Berwick, Jennifer L Hay
Genomic medicine has revolutionized disease risk identification and subsequent risk reduction interventions. Skin cancer risk genomic feedback is a promising vehicle to raise awareness and protective behaviors in the general population, including Hispanics who are largely unaware of their risks. Yet, personalized genomics currently has limited reach. This study is the initial phase of a randomized controlled trial investigating the personal utility and reach of genomic testing and feedback for melanoma. Semi-structured cognitive interviews (N = 28), stratified across education level, were conducted to assess the comprehension and acceptability of translated skin cancer genomic risk education materials with Spanish-speaking Hispanic primary care patients...
December 6, 2016: Journal of Community Genetics
https://www.readbyqxmd.com/read/27913671/l-rrk-de-triomphe-a-solution-for-lrrk2-gtpase-activity
#2
REVIEW
Jonathon Nixon-Abell, Daniel C Berwick, Kirsten Harvey
Leucine-rich repeat kinase 2 (LRRK2) is a central protein in the pathogenesis of Parkinson's disease (PD), yet its normal function has proved stubbornly hard to elucidate. Even though it remains unclear how pathogenic mutations affect LRRK2 to cause PD, recent findings provide increasing cause for optimism. We summarise here the developing consensus over the effect of pathogenic mutations in the Ras of complex proteins and C-terminal of Roc domains on LRRK2 GTPase activity. This body of work has been greatly reinforced by our own study of the protective R1398H variant contained within the LRRK2 GTPase domain...
December 15, 2016: Biochemical Society Transactions
https://www.readbyqxmd.com/read/27862570/communication-about-melanoma-and-risk-reduction-after-melanoma-diagnosis
#3
Vivian M Rodríguez, Marianne Berwick, Jennifer L Hay
BACKGROUND: Melanoma patients are advised to perform regular risk-reduction practices, including sun protection as well as skin self-examinations (SSEs) and physician-led examinations. Melanoma-specific communication regarding family risk and screening may promote such behaviors. To this end, associations between patients' melanoma-specific communication and risk reduction were examined. METHODS: Melanoma patients (N = 169) drawn from a population-based cancer registry reported their current risk-reduction practices, perceived risk of future melanoma, and communication with physicians and relatives about melanoma risk and screening...
November 15, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27798743/erratum-to-role-of-pulse-pressure-and-geometry-of-primary-entry-tear-in-acute-type-b-dissection-propagation
#4
Srikara V Peelukhana, Yanmin Wang, Zachary Berwick, Jarin Kratzberg, Joshua Krieger, Blayne Roeder, Rachel E Clough, Albert Hsiao, Sean Chambers, Ghassan S Kassab
No abstract text is available yet for this article.
October 31, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27784667/five-minutes-with-don-berwick
#5
Gareth Iacobucci
No abstract text is available yet for this article.
October 26, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27748080/variants-in-autophagy-related-genes-and-clinical-characteristics-in-melanoma-a-population-based-study
#6
Kirsten A M White, Li Luo, Todd A Thompson, Salina Torres, Chien-An Andy Hu, Nancy E Thomas, Jenna Lilyquist, Hoda Anton-Culver, Stephen B Gruber, Lynn From, Klaus J Busam, Irene Orlow, Peter A Kanetsky, Loraine D Marrett, Richard P Gallagher, Lidia Sacchetto, Stefano Rosso, Terence Dwyer, Anne E Cust, Colin B Begg, Marianne Berwick
Autophagy has been linked with melanoma risk and survival, but no polymorphisms in autophagy-related (ATG) genes have been investigated in relation to melanoma progression. We examined five single-nucleotide polymorphisms (SNPs) in three ATG genes (ATG5; ATG10; and ATG16L) with known or suspected impact on autophagic flux in an international population-based case-control study of melanoma. DNA from 911 melanoma patients was genotyped. An association was identified between (GG) (rs2241880) and earlier stage at diagnosis (OR 0...
November 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27727029/kaiser-permanente-northern-california-pregnancy-database-description-and-proof-of-concept-study
#7
Ousseny Zerbo, Berwick Chan, Kristin Goddard, Ned Lewis, Karin Bok, Nicola P Klein, Roger Baxter
BACKGROUND/OBJECTIVE: We describe the establishment of a dynamic database linking mothers to newborns with the goal of studying vaccine safety in both pregnant women and their children and provide results of a study utilizing this database as a proof of concept. METHODS: All Kaiser Permanente Northern California (KPNC) live births and their mothers were eligible for inclusion in the pregnancy database. We used the medical record number (MRN), a unique identifier, to retrieve information about events that occurred during the pregnancy and at delivery and linked this same MRN to newborns for post-partum follow up...
October 7, 2016: Vaccine
https://www.readbyqxmd.com/read/27715903/older-women-s-negative-psychological-and-physical-experiences-with-injectable-cosmetic-treatments-to-the-face
#8
Sandi Berwick, Áine Humble
Seven women (43 to 64 years old) who had negative or mixed emotions about having Botox and/or facial filler injections to the face to reduce signs of aging were interviewed about the impact of the procedures. Impacts ranged from disappointment to all-encompassing, lingering physical and psychological effects, and some women felt abandoned by the medical industrial complex when they turned to it for help with their symptoms. A feminist phenomenological analysis focused on corporeal, temporal, and relational existential modes of being...
August 11, 2016: Journal of Women & Aging
https://www.readbyqxmd.com/read/27646129/the-neurogenesis-of-p1-and-n1-a-concurrent-eeg-lfp-study
#9
Michael Bruyns-Haylett, Jingjing Luo, Aneurin J Kennerley, Sam Harris, Luke Boorman, Elizabeth Milne, Nicolas Vautrelle, Yurie Hayashi, Benjamin J Whalley, Myles Jones, Jason Berwick, Jorge Riera, Ying Zheng
It is generally recognised that event related potentials (ERPs) of electroencephalogram (EEG) primarily reflect summed post-synaptic activity of the local pyramidal neural population(s). However, it is still not understood how the positive and negative deflections (e.g. P1, N1 etc) observed in ERP recordings are related to the underlying excitatory and inhibitory post-synaptic activity. We investigated the neurogenesis of P1 and N1 in ERPs by pharmacologically manipulating inhibitory post-synaptic activity in the somatosensory cortex of rodent, and concurrently recording EEG and local field potentials (LFPs)...
September 16, 2016: NeuroImage
https://www.readbyqxmd.com/read/27626611/skin-cancer-risk-reduction-behaviors-among-american-indian-and-non-hispanic-white-persons-in-rural-new-mexico
#10
Mary E Logue, Tyler Hough, Yuridia Leyva, Jaron Kee, Marianne Berwick
No abstract text is available yet for this article.
September 14, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27601219/fluid-structure-interaction-simulations-of-aortic-dissection-with-bench-validation
#11
H Y Chen, S V Peelukhana, Z C Berwick, J Kratzberg, J F Krieger, B Roeder, S Chambers, G S Kassab
INTRODUCTION: The blood flow and stresses in the flap in aortic dissections are not well understood. Validated fluid-structure interaction (FSI) simulations of the interactions between the blood flow and the flap will provide insight into the dynamics of aortic dissections and may lead to developments of novel therapeutic approaches. METHODS: A coupled, two-way blood flow and flap wall computational model was developed. The Arbitrary Lagrange-Eulerian method was used, which allowed the fluid mesh to deform...
September 3, 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27584045/competing-risks-survival-of-older-patients-with-metastatic-cutaneous-melanoma-a-seer-population-based-study
#12
Jessica R Hoag, Upendra Hegde, Rebecca Zweifler, Marianne Berwick, Helen Swede
Mortality from metastatic cutaneous melanoma is substantially heterogeneous as reflected in three distant metastatic (M1) subtypes with metastasis to skin, subcutaneous tissue, or distant lymph nodes (M1a), conferring nearly half the risk of death compared with distant visceral metastasis (M1c). It remains unknown whether older patients experience the survival benefit from the M1a subtype given a higher overall mortality risk. Surveillance, Epidemiology, and End Result data were retrieved from 1878 metastatic melanoma patients, from 2005 to 2009, with follow-up through 2011...
October 2016: Melanoma Research
https://www.readbyqxmd.com/read/27567505/letter-from-donald-m-berwick-md-mpp-guest-editor
#13
Donald M Berwick
No abstract text is available yet for this article.
August 2016: American Journal of Managed Care
https://www.readbyqxmd.com/read/27557843/decreased-haemodynamic-response-and-decoupling-of-cortical-gamma-band-activity-and-tissue-oxygen-perfusion-after-striatal-interleukin-1-injection
#14
Natasha Bray, Fiona E Burrows, Myles Jones, Jason Berwick, Stuart M Allan, Ingo Schiessl
BACKGROUND: Neurovascular coupling describes the mechanism by which the energy and oxygen demand arising from neuronal activity is met by an increase in regional blood flow, known as the haemodynamic response. Interleukin 1 (IL-1) is a pro-inflammatory cytokine and an important mediator of neuronal injury, though mechanisms through which IL-1 exerts its effects in the brain are not fully understood. In this study, we set out to investigate if increased cerebral levels of IL-1 have a negative effect on the neurovascular coupling in the cortex in response to sensory stimulation...
2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27547619/the-influence-of-phthalocyanine-aggregation-in-complexes-with-cdse-zns-quantum-dots-on-the-photophysical-properties-of-the-complexes
#15
Irina V Martynenko, Anna O Orlova, Vladimir G Maslov, Anatoly V Fedorov, Kevin Berwick, Alexander V Baranov
The formation of nonluminescent aggregates of aluminium sulfonated phthalocyanine in complexes with CdSe/ZnS quantum dots causes a decrease of the intracomplex energy transfer efficiency with increasing phthalocyanine concentration. This was confirmed by steady-state absorption and photoluminescent spectroscopy. A corresponding physical model was developed that describes well the experimental data. The results can be used at designing of QD/molecule systems with the desired spatial arrangement for photodynamic therapy...
2016: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/27510916/role-of-pulse-pressure-and-geometry-of-primary-entry-tear-in-acute-type-b-dissection-propagation
#16
Srikara V Peelukhana, Yanmin Wang, Zachary Berwick, Jarin Kratzberg, Joshua Krieger, Blayne Roeder, Rachel E Cloughs, Albert Hsiao, Sean Chambers, Ghassan S Kassab
The hemodynamic and geometric factors leading to propagation of acute Type B dissections are poorly understood. The objective is to elucidate whether geometric and hemodynamic parameters increase the predilection for aortic dissection propagation. A pulse duplicator set-up was used on porcine aorta with a single entry tear. Mean pressures of 100 and 180 mmHg were used, with pulse pressures ranging from 40 to 200 mmHg. The propagation for varying geometric conditions (%circumference of the entry tear: 15-65%, axial length: 0...
August 10, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27368624/marr-s-levels-and-the-minimalist-program
#17
Mark Johnson
A simple change to a cognitive system at Marr's computational level may entail complex changes at the other levels of description of the system. The implementational level complexity of a change, rather than its computational level complexity, may be more closely related to the plausibility of a discrete evolutionary event causing that change. Thus the formal complexity of a change at the computational level may not be a good guide to the plausibility of an evolutionary event introducing that change. For example, while the Minimalist Program's Merge is a simple formal operation (Berwick & Chomsky, 2016), the computational mechanisms required to implement the language it generates (e...
July 1, 2016: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/27320410/the-study-of-nevi-in-children-principles-learned-and-implications-for-melanoma-diagnosis
#18
REVIEW
Alon Scope, Michael A Marchetti, Ashfaq A Marghoob, Stephen W Dusza, Alan C Geller, Jaya M Satagopan, Martin A Weinstock, Marianne Berwick, Allan C Halpern
Melanocytic nevi are a strong phenotypic marker of cutaneous melanoma risk. Changes in nevi during childhood and adolescence make these prime periods for studying nevogenesis. Insights gained by the study of nevi in childhood have implications for melanoma detection in both adults and children. A more comprehensive understanding of the morphologic characteristics of nevi in different anatomic locations, in association with the patient's age and pigmentary phenotype may aid in the identification of melanomas...
October 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27315351/a-national-trauma-care-system-to-achieve-zero-preventable-deaths-after-injury-recommendations-from-a-national-academies-of-sciences-engineering-and-medicine-report
#19
Donald M Berwick, Autumn S Downey, Elizabeth A Cornett
No abstract text is available yet for this article.
September 6, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27265554/-evaluating-the-quality-of-medical-care-donabedian-s-classic-article-50-years-later
#20
Donald Berwick, Daniel M Fox
No abstract text is available yet for this article.
June 2016: Milbank Quarterly
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