keyword
https://read.qxmd.com/read/38433458/successful-implementation-of-the-aium-standardized-4-year-residency-ultrasound-curriculum-in-obstetrics-and-gynecology-lessons-learned-and-way-forward
#1
JOURNAL ARTICLE
Reem S Abu-Rustum, Margarita Berwick, Jessica Heft
BACKGROUND: Significant disparities in sonographic education exist in Obstetrics and Gynecology programs in the United States. To address the lack of standardization in ultrasound teaching, the American Institute of Ultrasound in Medicine (AIUM) assembled a multi-society task force in 2018 which resulted in the publication of a Consensus Report outlining a standardized ultrasound curriculum and competency assessment. OBJECTIVES: The primary objective of the study was to implement the AUIM standardized curriculum within an Obstetrics and Gynecology residency program at a tertiary medical center, and report on the early implementation experience...
March 3, 2024: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://read.qxmd.com/read/38214679/experiences-of-bias-in-a-multidisciplinary-hospital-medicine-group
#2
JOURNAL ARTICLE
Gabrielle Kis Bromberg, Jessica R Berwick, Nora K Horick, Sherri-Ann M Burnett-Bowie
Clinicians report experiencing bias at work. Although previous studies have characterized these experiences among trainees and clinical faculty, ours is the first to describe experiences of bias within a multidisciplinary hospital medicine group. In our study, 82.5% of surveyed nurse practitioners (NPs), physician assistants (PAs), and physicians reported experiencing gender, racial, or other forms of bias in the workplace. In addition to women reporting higher rates of gender bias and Asian/Black/Latinx/multiracial/other race respondents reporting higher rates of racial bias, half of participants reported experiencing other forms of bias related to gender expression, perceived sexual orientation, body habitus, age, accent, country of origin, or perceived socioeconomic status...
January 12, 2024: Journal of the American Association of Nurse Practitioners
https://read.qxmd.com/read/37941765/a-multi-disciplinary-commentary-on-preclinical-research-to-investigate-vascular-contributions-to-dementia
#3
REVIEW
Sarmi Sri, Adam Greenstein, Alessandra Granata, Alex Collcutt, Angela C C Jochems, Barry W McColl, Blanca Díaz Castro, Caleb Webber, Carmen Arteaga Reyes, Catherine Hall, Catherine B Lawrence, Cheryl Hawkes, Chrysia-Maria Pegasiou-Davies, Claire Gibson, Colin L Crawford, Colin Smith, Denis Vivien, Fiona H McLean, Frances Wiseman, Gaia Brezzo, Giovanna Lalli, Harry A T Pritchard, Hugh S Markus, Isabel Bravo-Ferrer, Jade Taylor, James Leiper, Jason Berwick, Jian Gan, John Gallacher, Jonathan Moss, Jozien Goense, Letitia McMullan, Lorraine Work, Lowri Evans, Michael S Stringer, Mlj Ashford, Mohamed Abulfadl, Nina Conlon, Paresh Malhotra, Philip Bath, Rebecca Canter, Rosalind Brown, Selvi Ince, Silvia Anderle, Simon Young, Sophie Quick, Stefan Szymkowiak, Steve Hill, Stuart Allan, Tao Wang, Terry Quinn, Tessa Procter, Tracy D Farr, Xiangjun Zhao, Zhiyuan Yang, Atticus H Hainsworth, Joanna M Wardlaw
Although dementia research has been dominated by Alzheimer's disease (AD), most dementia in older people is now recognised to be due to mixed pathologies, usually combining vascular and AD brain pathology. Vascular cognitive impairment (VCI), which encompasses vascular dementia (VaD) is the second most common type of dementia. Models of VCI have been delayed by limited understanding of the underlying aetiology and pathogenesis. This review by a multidisciplinary, diverse (in terms of sex, geography and career stage), cross-institute team provides a perspective on limitations to current VCI models and recommendations for improving translation and reproducibility...
2023: Cerebral circulation—cognition and behavior
https://read.qxmd.com/read/37500216/prenatal-counseling-and-preparation-for-breastfeeding
#4
REVIEW
Margarita Berwick, Adetola F Louis-Jacques
Breastfeeding is the gold standard of infant nutrition and current guidelines suggest exclusive breastfeeding for 6 months, with continued breastfeeding through 24 months or beyond. Obstetric care professionals can encourage and educate their patients about breastfeeding through the prenatal period when many expectant parents make decisions about their infant feeding choices. Education and support should extend through the postpartum period and include parents who may have concerns surrounding medical comorbidities, breast augmentation, or substance use disorders...
September 2023: Obstetrics and Gynecology Clinics of North America
https://read.qxmd.com/read/37494457/association-of-functional-inherited-vitamin-d-binding-protein-variants-with-melanoma-specific-death
#5
JOURNAL ARTICLE
David Corley Gibbs, Nancy E Thomas, Peter A Kanetsky, Li Luo, Klaus J Busam, Anne E Cust, Hoda Anton-Culver, Richard P Gallagher, Roberto Zanetti, Stefano Rosso, Lidia Sacchetto, Sharon N Edmiston, Kathleen Conway, David W Ollila, Colin B Begg, Marianne Berwick, Sarah V Ward, Irene Orlow
BACKGROUND: It is unclear whether genetic variants affecting vitamin D metabolism are associated with melanoma prognosis. Two functional missense variants in the vitamin D-binding protein gene (GC), rs7041 and rs4588, determine three common haplotypes Gc1s, Gc1f, and Gc2. Gc1f may be associated with decreased all-cause death among melanoma patients, based on results of a prior study, but its association with melanoma-specific death is unclear. METHODS: We investigated the association of the Gc1s, Gc1f, and Gc2 haplotypes with melanoma-specific and all-cause death among 4,490 individuals with incident, invasive primary melanoma in two population-based studies using multivariable Cox-proportional hazards regression...
July 26, 2023: JNCI Cancer Spectrum
https://read.qxmd.com/read/37463405/competency-based-medical-education-the-spark-to-ignite-healthcare-s-escape%C3%A2-fire
#6
JOURNAL ARTICLE
Daniel J Schumacher, Benjamin Kinnear, Carol Carraccio, Eric Holmboe, Jamiu O Busari, Cees van der Vleuten, Lorelei Lingard
High-value care is what patients deserve and what healthcare professionals should deliver. However, it is not what happens much of the time. Quality improvement master Dr. Don Berwick argued more than two decades ago that American healthcare needs an escape fire , which is a new way of seeing and acting in a crisis situation. While coined in the U.S. context, the analogy applies in other Western healthcare contexts as well. Therefore, in this paper, the authors revisit Berwick's analogy, arguing that medical education can, and should, provide the spark for such an escape fire across the globe...
July 18, 2023: Medical Teacher
https://read.qxmd.com/read/37395773/greed-in-us-health-care-reply
#7
LETTER
Donald M Berwick
No abstract text is available yet for this article.
July 3, 2023: JAMA
https://read.qxmd.com/read/37345045/sex-specific-associations-of-mdm2-and-mdm4-variants-with-risk-of-multiple-primary-melanomas-and-melanoma-survival-in-non-hispanic-whites
#8
JOURNAL ARTICLE
Sarah V Ward, Isidora Autuori, Li Luo, Emily LaPilla, Sarah Yoo, Ajay Sharma, Klaus J Busam, David W Olilla, Terence Dwyer, Hoda Anton-Culver, Roberto Zanetti, Lidia Sacchetto, Anne E Cust, Richard P Gallagher, Peter A Kanetsky, Stefano Rosso, Colin B Begg, Marianne Berwick, Nancy E Thomas, Irene Orlow
MDM2 -SNP309 (rs2279744), a common genetic modifier of cancer incidence in Li-Fraumeni syndrome, modifies risk, age of onset, or prognosis in a variety of cancers. Melanoma incidence and outcomes vary by sex, and although SNP309 exerts an effect on the estrogen receptor, no consensus exists on its effect on melanoma. MDM2 and MDM4 restrain p53-mediated tumor suppression, independently or together. We investigated SNP309, an a priori MDM4 -rs4245739, and two coinherited variants, in a population-based cohort of 3663 primary incident melanomas...
May 11, 2023: Cancers
https://read.qxmd.com/read/37318542/twelve-tips-for-practical-clinical-skills-coaching
#9
JOURNAL ARTICLE
Jean E Klig, Bryan A Stenson, Sean M Kivlehan, Agnieszka Jackson, Jessica R Berwick, Joshua M Kosowsky
Coaching is rapidly evolving in clinical medicine, including for clinical skills (CS) learning. Yet a schema is needed for how to coach students in the many CS that are pivotal to the practice of medicine. These twelve tips aim to provide practical strategies for teachers and educators to coach students for CS learning. The tips cover many important aspects of CS coaching, including establishing a safe space, ways to prepare to coach, setting goals, guiding a coaching relationship, fostering coaching conversations, and in-person or virtual approaches...
June 15, 2023: Medical Teacher
https://read.qxmd.com/read/37011054/intermel-an-international-biorepository-and-clinical-database-to-uncover-predictors-of-survival-in-early-stage-melanoma
#10
JOURNAL ARTICLE
Irene Orlow, Keimya D Sadeghi, Sharon N Edmiston, Jessica M Kenney, Cecilia Lezcano, James S Wilmott, Anne E Cust, Richard A Scolyer, Graham J Mann, Tim K Lee, Hazel Burke, Valerie Jakrot, Ping Shang, Peter M Ferguson, Tawny W Boyce, Jennifer S Ko, Peter Ngo, Pauline Funchain, Judy R Rees, Kelli O'Connell, Honglin Hao, Eloise Parrish, Kathleen Conway, Paul B Googe, David W Ollila, Stergios J Moschos, Eva Hernando, Douglas Hanniford, Diana Argibay, Christopher I Amos, Jeffrey E Lee, Iman Osman, Li Luo, Pei-Fen Kuan, Arshi Aurora, Bonnie E Gould Rothberg, Marcus W Bosenberg, Meg R Gerstenblith, Cheryl Thompson, Paul N Bogner, Ivan P Gorlov, Sheri L Holmen, Elise K Brunsgaard, Yvonne M Saenger, Ronglai Shen, Venkatraman Seshan, Eduardo Nagore, Marc S Ernstoff, Klaus J Busam, Colin B Begg, Nancy E Thomas, Marianne Berwick
INTRODUCTION: We are conducting a multicenter study to identify classifiers predictive of disease-specific survival in patients with primary melanomas. Here we delineate the unique aspects, challenges, and best practices for optimizing a study of generally small-sized pigmented tumor samples including primary melanomas of at least 1.05mm from AJTCC TNM stage IIA-IIID patients. We also evaluated tissue-derived predictors of extracted nucleic acids' quality and success in downstream testing...
2023: PloS One
https://read.qxmd.com/read/36995939/phosphoantigen-sensing-combines-tcr-dependent-recognition-of-the-btn3a-igv-domain-and-germline-interaction-with-btn2a1
#11
JOURNAL ARTICLE
Carrie R Willcox, Mahboob Salim, Charlotte R Begley, Mohindar M Karunakaran, Emily J Easton, Carlotta von Klopotek, Katie A Berwick, Thomas Herrmann, Fiyaz Mohammed, Mark Jeeves, Benjamin E Willcox
Vγ9Vδ2 T cells play critical roles in microbial immunity by detecting target cells exposed to pathogen-derived phosphoantigens (P-Ags). Target cell expression of BTN3A1, the "P-Ag sensor," and BTN2A1, a direct ligand for T cell receptor (TCR) Vγ9, is essential for this process; however, the molecular mechanisms involved are unclear. Here, we characterize BTN2A1 interactions with Vγ9Vδ2 TCR and BTN3A1. Nuclear magnetic resonance (NMR), modeling, and mutagenesis establish a BTN2A1-immunoglobulin V (IgV)/BTN3A1-IgV structural model compatible with their cell-surface association in cis...
March 28, 2023: Cell Reports
https://read.qxmd.com/read/36926987/pathway-alterations-in-stage-ii-iii-primary-melanoma
#12
JOURNAL ARTICLE
Caroline E Kostrzewa, Li Luo, Arshi Arora, Venkatraman E Seshan, Marc S Ernstoff, Sharon N Edmiston, Kathleen Conway, Ivan Gorlov, Klaus Busam, Irene Orlow, Eva Hernando-Monge, Nancy E Thomas, Marianne Berwick, Colin B Begg, Ronglai Shen
PURPOSE: Genomic classification of melanoma has thus far focused on the mutational status of BRAF , NRAS , and NF1 . The clinical utility of this classification remains limited, and the landscape of alterations in other oncogenic signaling pathways is underexplored. METHODS: Using primary samples from the InterMEL study, a retrospective cohort of cases with specimens collected from an international consortium with participating institutions throughout the United States and Australia, with oversampling of cases who ultimately died of melanoma, we examined mutual exclusivity and co-occurrence of genomic alterations in 495 stage II/III primary melanomas across 11 cancer pathways...
March 2023: JCO Precision Oncology
https://read.qxmd.com/read/36858889/corrigendum-to-use-of-transversus-abdominus-block-for-alveolar-bone-graft-analgesia-in-children-br-j-anaesth-2021-127-e123-e125
#13
Richard J Berwick, Charlotte Berwick, Joanne Haidon, Jennie Craske
No abstract text is available yet for this article.
February 27, 2023: British Journal of Anaesthesia
https://read.qxmd.com/read/36856971/the-effects-of-exposure-to-solar-radiation-on-human-health
#14
JOURNAL ARTICLE
R E Neale, R M Lucas, S N Byrne, L Hollestein, L E Rhodes, S Yazar, A R Young, M Berwick, R A Ireland, C M Olsen
This assessment by the Environmental Effects Assessment Panel (EEAP) of the Montreal Protocol under the United Nations Environment Programme (UNEP) evaluates the effects of ultraviolet (UV) radiation on human health within the context of the Montreal Protocol and its Amendments. We assess work published since our last comprehensive assessment in 2018. Over the last four years gains have been made in knowledge of the links between sun exposure and health outcomes, mechanisms, and estimates of disease burden, including economic impacts...
March 1, 2023: Photochemical & Photobiological Sciences
https://read.qxmd.com/read/36805567/methylation-of-nonessential-genes-in-cutaneous-melanoma-rule-out-hypothesis
#15
JOURNAL ARTICLE
Ivan P Gorlov, Kathleen Conway, Sharon N Edmiston, Eloise A Parrish, Honglin Hao, Christopher I Amos, Spiridon Tsavachidis, Olga Y Gorlova, Colin Begg, Eva Hernando, Chao Cheng, Ronglai Shen, Irene Orlow, Li Luo, Marc S Ernstoff, Pei Fen Kuan, David W Ollila, Yihsuan S Tsai, Marianne Berwick, Nancy E Thomas
Differential methylation plays an important role in melanoma development and is associated with survival, progression and response to treatment. However, the mechanisms by which methylation promotes melanoma development are poorly understood. The traditional explanation of selective advantage provided by differential methylation postulates that hypermethylation of regulatory 5'-cytosine-phosphate-guanine-3' dinucleotides (CpGs) downregulates the expression of tumor suppressor genes and therefore promotes tumorigenesis...
February 20, 2023: Melanoma Research
https://read.qxmd.com/read/36797344/bidirectional-alterations-in-brain-temperature-profoundly-modulate-spatiotemporal-neurovascular-responses-in-vivo
#16
JOURNAL ARTICLE
Luke W Boorman, Samuel S Harris, Osman Shabir, Llywelyn Lee, Beth Eyre, Clare Howarth, Jason Berwick
Neurovascular coupling (NVC) is a mechanism that, amongst other known and latent critical functions, ensures activated brain regions are adequately supplied with oxygen and glucose. This biological phenomenon underpins non-invasive perfusion-related neuroimaging techniques and recent reports have implicated NVC impairment in several neurodegenerative disorders. Yet, much remains unknown regarding NVC in health and disease, and only recently has there been burgeoning recognition of a close interplay with brain thermodynamics...
February 17, 2023: Communications Biology
https://read.qxmd.com/read/36776434/hospital-noncompliance-with-u-s-price-transparency-regulations
#17
JOURNAL ARTICLE
Amitai S Miller, Stephen A Stearns, Donald M Berwick
No abstract text is available yet for this article.
August 2022: Lancet Reg Health Am
https://read.qxmd.com/read/36753053/international-prospective-cohort-study-comparing-non-absorbable-versus-absorbable-sutures-for-skin-surgery-canvas-service-evaluation
#18
JOURNAL ARTICLE
Alice Lee, Guy H M Stanley, Ryckie G Wade, Daniele Berwick, Victoria Vinicombe, Brogan K Salence, Esra Musbahi, Anderson R C S De Poli, Mihaela Savu, Jonathan M Batchelor, Rachel A Abbott, Matthew D Gardiner, Aaron Wernham, David Veitch
BACKGROUND: Absorbable or non-absorbable sutures can be used for superficial skin closure following excisional skin surgery. There is no consensus among clinicians nor high-quality evidence supporting the choice of suture. The aim of the present study was to determine current suture use and complications at 30 days after excisional skin surgery. METHODS: An international, prospective service evaluation of adults undergoing excision of skin lesions (benign and malignant) in primary and secondary care was conducted from 1 September 2020 to 15 April 2021...
March 30, 2023: British Journal of Surgery
https://read.qxmd.com/read/36716043/salve-lucrum-the-existential-threat-of-greed-in-us-health-care
#19
JOURNAL ARTICLE
Donald M Berwick
No abstract text is available yet for this article.
January 30, 2023: JAMA
https://read.qxmd.com/read/36701134/risk-factors-symptoms-and-treatment-of-lactational-mastitis
#20
JOURNAL ARTICLE
Adetola F Louis-Jacques, Margarita Berwick, Katrina B Mitchell
No abstract text is available yet for this article.
February 21, 2023: JAMA
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