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Kirsten A M White, Li Luo, Todd A Thompson, Salina Torres, Chien-An Andy Hu, Nancy E Thomas, Jenna Lilyquist, Hoda Anton-Culver, Stephen B Gruber, Lynn From, Klaus J Busam, Irene Orlow, Peter A Kanetsky, Loraine D Marrett, Richard P Gallagher, Lidia Sacchetto, Stefano Rosso, Terence Dwyer, Anne E Cust, Colin B Begg, Marianne Berwick
Autophagy has been linked with melanoma risk and survival, but no polymorphisms in autophagy-related (ATG) genes have been investigated in relation to melanoma progression. We examined five single-nucleotide polymorphisms (SNPs) in three ATG genes (ATG5; ATG10; and ATG16L) with known or suspected impact on autophagic flux in an international population-based case-control study of melanoma. DNA from 911 melanoma patients was genotyped. An association was identified between (GG) (rs2241880) and earlier stage at diagnosis (OR 0...
October 17, 2016: Cancer Medicine
Ousseny Zerbo, Berwick Chan, Kristin Goddard, Ned Lewis, Karin Bok, Nicola P Klein, Roger Baxter
BACKGROUND/OBJECTIVE: We describe the establishment of a dynamic database linking mothers to newborns with the goal of studying vaccine safety in both pregnant women and their children and provide results of a study utilizing this database as a proof of concept. METHODS: All Kaiser Permanente Northern California (KPNC) live births and their mothers were eligible for inclusion in the pregnancy database. We used the medical record number (MRN), a unique identifier, to retrieve information about events that occurred during the pregnancy and at delivery and linked this same MRN to newborns for post-partum follow up...
October 7, 2016: Vaccine
Sandi Berwick, Áine Humble
Seven women (43 to 64 years old) who had negative or mixed emotions about having Botox and/or facial filler injections to the face to reduce signs of aging were interviewed about the impact of the procedures. Impacts ranged from disappointment to all-encompassing, lingering physical and psychological effects, and some women felt abandoned by the medical industrial complex when they turned to it for help with their symptoms. A feminist phenomenological analysis focused on corporeal, temporal, and relational existential modes of being...
August 11, 2016: Journal of Women & Aging
Michael Bruyns-Haylett, Jingjing Luo, Aneurin J Kennerley, Sam Harris, Luke Boorman, Elizabeth Milne, Nicolas Vautrelle, Yurie Hayashi, Benjamin J Whalley, Myles Jones, Jason Berwick, Jorge Riera, Ying Zheng
It is generally recognised that event related potentials (ERPs) of electroencephalogram (EEG) primarily reflect summed post-synaptic activity of the local pyramidal neural population(s). However, it is still not understood how the positive and negative deflections (e.g. P1, N1 etc) observed in ERP recordings are related to the underlying excitatory and inhibitory post-synaptic activity. We investigated the neurogenesis of P1 and N1 in ERPs by pharmacologically manipulating inhibitory post-synaptic activity in the somatosensory cortex of rodent, and concurrently recording EEG and local field potentials (LFPs)...
September 16, 2016: NeuroImage
Mary E Logue, Tyler Hough, Yuridia Leyva, Jaron Kee, Marianne Berwick
No abstract text is available yet for this article.
September 14, 2016: JAMA Dermatology
H Y Chen, S V Peelukhana, Z C Berwick, J Kratzberg, J F Krieger, B Roeder, S Chambers, G S Kassab
INTRODUCTION: The blood flow and stresses in the flap in aortic dissections are not well understood. Validated fluid-structure interaction (FSI) simulations of the interactions between the blood flow and the flap will provide insight into the dynamics of aortic dissections and may lead to developments of novel therapeutic approaches. METHODS: A coupled, two-way blood flow and flap wall computational model was developed. The Arbitrary Lagrange-Eulerian method was used, which allowed the fluid mesh to deform...
September 3, 2016: European Journal of Vascular and Endovascular Surgery
Jessica R Hoag, Upendra Hegde, Rebecca Zweifler, Marianne Berwick, Helen Swede
Mortality from metastatic cutaneous melanoma is substantially heterogeneous as reflected in three distant metastatic (M1) subtypes with metastasis to skin, subcutaneous tissue, or distant lymph nodes (M1a), conferring nearly half the risk of death compared with distant visceral metastasis (M1c). It remains unknown whether older patients experience the survival benefit from the M1a subtype given a higher overall mortality risk. Surveillance, Epidemiology, and End Result data were retrieved from 1878 metastatic melanoma patients, from 2005 to 2009, with follow-up through 2011...
October 2016: Melanoma Research
Donald M Berwick
No abstract text is available yet for this article.
August 2016: American Journal of Managed Care
Natasha Bray, Fiona E Burrows, Myles Jones, Jason Berwick, Stuart M Allan, Ingo Schiessl
BACKGROUND: Neurovascular coupling describes the mechanism by which the energy and oxygen demand arising from neuronal activity is met by an increase in regional blood flow, known as the haemodynamic response. Interleukin 1 (IL-1) is a pro-inflammatory cytokine and an important mediator of neuronal injury, though mechanisms through which IL-1 exerts its effects in the brain are not fully understood. In this study, we set out to investigate if increased cerebral levels of IL-1 have a negative effect on the neurovascular coupling in the cortex in response to sensory stimulation...
2016: Journal of Neuroinflammation
Irina V Martynenko, Anna O Orlova, Vladimir G Maslov, Anatoly V Fedorov, Kevin Berwick, Alexander V Baranov
The formation of nonluminescent aggregates of aluminium sulfonated phthalocyanine in complexes with CdSe/ZnS quantum dots causes a decrease of the intracomplex energy transfer efficiency with increasing phthalocyanine concentration. This was confirmed by steady-state absorption and photoluminescent spectroscopy. A corresponding physical model was developed that describes well the experimental data. The results can be used at designing of QD/molecule systems with the desired spatial arrangement for photodynamic therapy...
2016: Beilstein Journal of Nanotechnology
Srikara V Peelukhana, Yanmin Wang, Zachary Berwick, Jarin Kratzberg, Joshua Krieger, Blayne Roeder, Rachel E Cloughs, Albert Hsiao, Sean Chambers, Ghassan S Kassab
The hemodynamic and geometric factors leading to propagation of acute Type B dissections are poorly understood. The objective is to elucidate whether geometric and hemodynamic parameters increase the predilection for aortic dissection propagation. A pulse duplicator set-up was used on porcine aorta with a single entry tear. Mean pressures of 100 and 180 mmHg were used, with pulse pressures ranging from 40 to 200 mmHg. The propagation for varying geometric conditions (%circumference of the entry tear: 15-65%, axial length: 0...
August 10, 2016: Annals of Biomedical Engineering
Mark Johnson
A simple change to a cognitive system at Marr's computational level may entail complex changes at the other levels of description of the system. The implementational level complexity of a change, rather than its computational level complexity, may be more closely related to the plausibility of a discrete evolutionary event causing that change. Thus the formal complexity of a change at the computational level may not be a good guide to the plausibility of an evolutionary event introducing that change. For example, while the Minimalist Program's Merge is a simple formal operation (Berwick & Chomsky, 2016), the computational mechanisms required to implement the language it generates (e...
July 1, 2016: Psychonomic Bulletin & Review
Alon Scope, Michael A Marchetti, Ashfaq A Marghoob, Stephen W Dusza, Alan C Geller, Jaya M Satagopan, Martin A Weinstock, Marianne Berwick, Allan C Halpern
Melanocytic nevi are a strong phenotypic marker of cutaneous melanoma risk. Changes in nevi during childhood and adolescence make these prime periods for studying nevogenesis. Insights gained by the study of nevi in childhood have implications for melanoma detection in both adults and children. A more comprehensive understanding of the morphologic characteristics of nevi in different anatomic locations, in association with the patient's age and pigmentary phenotype may aid in the identification of melanomas...
October 2016: Journal of the American Academy of Dermatology
Donald M Berwick, Autumn S Downey, Elizabeth A Cornett
No abstract text is available yet for this article.
September 6, 2016: JAMA: the Journal of the American Medical Association
Donald Berwick, Daniel M Fox
No abstract text is available yet for this article.
June 2016: Milbank Quarterly
Tejal K Gandhi, Donald M Berwick, Kaveh G Shojania
No abstract text is available yet for this article.
May 3, 2016: JAMA: the Journal of the American Medical Association
Nicholas J Taylor, Nancy E Thomas, Hoda Anton-Culver, Bruce K Armstrong, Colin B Begg, Klaus J Busam, Anne E Cust, Terence Dwyer, Lynn From, Richard P Gallagher, Stephen B Gruber, Diane E Nishri, Irene Orlow, Stefano Rosso, Alison J Venn, Roberto Zanetti, Marianne Berwick, Peter A Kanetsky
Although nevus count is an established risk factor for melanoma, relationships between nevus number and patient and tumor characteristics have not been well studied and the influence of nevus count on melanoma-specific survival is equivocal. Using data from the Genes, Environment and Melanoma (GEM) study, a large population-based study of primary cutaneous melanoma, we evaluated associations between number of nevi and patient features, including sun-sensitivity summarized in a phenotypic index, and tumor characteristics...
September 15, 2016: International Journal of Cancer. Journal International du Cancer
R Slack, L Boorman, P Patel, S Harris, M Bruyns-Haylett, A Kennerley, M Jones, J Berwick
BACKGROUND: Many brain imaging techniques interpret the haemodynamic response as an indirect indicator of underlying neural activity. However, a challenge when interpreting this blood based signal is how changes in brain state may affect both baseline and stimulus evoked haemodynamics. NEW METHOD: We developed an Automatic Brain State Classifier (ABSC), validated on data from anaesthetised rodents. It uses vectorised information obtained from the windowed spectral frequency power of the Local Field Potential...
July 15, 2016: Journal of Neuroscience Methods
Yousef Hawsawi, Matthew P Humphries, Alexander Wright, Angelene Berwick, Mike Shires, Hanaa Al-Kharobi, Reem El-Gendy, Maria Jove, Chris Twelves, Valerie Speirs, James Beattie
Tamoxifen (TAM) remains the adjuvant therapy of choice for pre-menopausal women with ERα-positive breast cancer. Resistance and recurrence remain, however, a major challenge with many women relapsing and subsequently dying. The insulin-like growth factor (IGF) axis is involved in breast cancer pathogenesis and progression to endocrine resistant disease, but there is very little data on the expression and potential role of IGF-binding proteins (IGFBP) during acquisition of the resistant phenotype. The aim of this study was to determine the expression and functional role of IGFBP-2 and -5 in the development of TAM resistance (TamR) in vitro and to test retrospectively whether they were predictive of resistance in a tissue microarray of 77 women with primary breast cancers who relapsed on/after endocrine therapy and 193 who did not with long term follow up...
May 31, 2016: Oncotarget
Huan Chen, Xuefeng Zhao, Zachary C Berwick, Joshua F Krieger, Sean Chambers, Ghassan S Kassab
There is a significant need for fixed biological tissues with desired structural and material constituents for tissue engineering applications. Here, we introduce the lung ligament as a fixed biological material that may have clinical utility for tissue engineering. To characterize the lung tissue for potential clinical applications, we studied glutaraldehyde-treated porcine pulmonary ligament (n = 11) with multiphoton microscopy (MPM) and conducted biaxial planar experiments to characterize the mechanical property of the tissue...
June 2016: Journal of Biomechanical Engineering
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