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https://www.readbyqxmd.com/read/28746718/association-of-incident-amelanotic-melanoma-with-phenotypic-characteristics-mc1r-status-and-prior-amelanotic-melanoma
#1
Steven Vernali, Weston T Waxweiler, Patrick M Dillon, Peter A Kanetsky, Irene Orlow, Li Luo, Klaus J Busam, Anne Kricker, Bruce K Armstrong, Hoda Anton-Culver, Stephen B Gruber, Richard P Gallagher, Roberto Zanetti, Stefano Rosso, Lidia Sacchetto, Terence Dwyer, Anne E Cust, David W Ollila, Colin B Begg, Marianne Berwick, Nancy E Thomas
Importance: We previously reported that survival is poorer from histopathologically amelanotic than pigmented melanoma because of more advanced stage at diagnosis. Identifying patients at risk of amelanotic melanoma might enable earlier diagnosis and improved survival; however, the phenotypic characteristics and underlying genetics associated with amelanotic melanoma are unknown. Objective: To determine whether phenotypic characteristics, carriage of MC1R variants, and history of amelanotic melanoma are associated with histopathologically amelanotic melanoma...
July 26, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28617907/reducing-excessive-use-of-antipsychotic-agents-in-nursing-homes
#2
Jerry H Gurwitz, Alice Bonner, Donald M Berwick
No abstract text is available yet for this article.
July 11, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28617013/the-role-of-policy-in-supporting-clinician-led-research-on-behavioral-health-integration
#3
Nathaniel Z Counts
In Best Care at Lower Cost, the Institute of Medicine laid out a vision for continuously learning health systems (Institute of Medicine of the National Academies, 2016). This issue of Families, Systems, & Health represents a substantial step toward this vision, with on-the-ground clinicians and administrators testing empirically informed hypotheses about practice transformation and population health management, and using those results to produce shared learning within and across systems. While the studies in this issue demonstrate that producing generalizable knowledge from clinician-led initiatives is feasible, they also demonstrate that the current system does not adequately support clinicians in doing so...
June 2017: Families, Systems & Health: the Journal of Collaborative Family Healthcare
https://www.readbyqxmd.com/read/28592416/understanding-the-american-healthcare-reform-debate
#4
Donald M Berwick
No abstract text is available yet for this article.
June 7, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28494491/topical-delivery-of-anti-vegf-drugs-to-the-ocular-posterior-segment-using-cell-penetrating-peptides
#5
Felicity de Cogan, Lisa J Hill, Aisling Lynch, Peter J Morgan-Warren, Judith Lechner, Matthew R Berwick, Anna F A Peacock, Mei Chen, Robert A H Scott, Heping Xu, Ann Logan
Purpose: To evaluate the efficacy of anti-VEGF agents for treating choroidal neovascularization (CNV) when delivered topically using novel cell-penetrating peptides (CPPs) compared with delivery by intravitreal (ivit) injection. Methods: CPP toxicity was investigated in cell cultures. Ivit concentrations of ranibizumab and bevacizumab after topical administration were measured using ELISA. The biological efficacy of topical anti-VEGF + CPP complexes was compared with ivit anti-VEGF injections using an established model of CNV...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28483192/no-association-between-influenza-vaccination-during-pregnancy-and-adverse-birth-outcomes
#6
Ousseny Zerbo, Sharareh Modaressi, Berwick Chan, Kristin Goddard, Ned Lewis, Karin Bok, Bruce Fireman, Nicola P Klein, Roger Baxter
BACKGROUND: Pregnant women are recommended to receive inactivated influenza vaccination anytime during pregnancy. Studies have investigated the impact of influenza vaccination during pregnancy on birth outcomes and results on preterm birth have been inconsistent. METHODS: We conducted a retrospective cohort study among children born at a gestational age≥24weeks from January 1, 2010 to December 31, 2015 at Kaiser Permanente Northern California facilities (KPNC)...
May 31, 2017: Vaccine
https://www.readbyqxmd.com/read/28448652/breaking-the-rules-for-better-care
#7
Donald M Berwick, Saranya Loehrer, Christina Gunther-Murphy
No abstract text is available yet for this article.
June 6, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28442450/implementing-an-internet-delivered-skin-cancer-genetic-testing-intervention-to-improve-sun-protection-behavior-in-a-diverse-population-protocol-for-a-randomized-controlled-trial
#8
Jennifer L Hay, Marianne Berwick, Kate Zielaskowski, Kirsten Am White, Vivian M Rodríguez, Erika Robers, Dolores D Guest, Andrew Sussman, Yvonne Talamantes, Matthew R Schwartz, Jennie Greb, Jessica Bigney, Kimberly A Kaphingst, Keith Hunley, David B Buller
BACKGROUND: Limited translational genomic research currently exists to guide the availability, comprehension, and appropriate use of personalized genomics in diverse general population subgroups. Melanoma skin cancers are preventable, curable, common in the general population, and disproportionately increasing in Hispanics. OBJECTIVE: Variants in the melanocortin-1 receptor (MC1R) gene are present in approximately 50% of the population, are major factors in determining sun sensitivity, and confer a 2-to-3-fold increase in melanoma risk in the general population, even in populations with darker skin...
April 25, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28383822/preparing-childhood-cancer-survivors-for-transition-to-adult-care-the-young-adult-perspective
#9
Natasha N Frederick, Sharon L Bober, Lexie Berwick, Mary Tower, Lisa B Kenney
BACKGROUND: Childhood cancer survivors (CCSs) remain at risk for developing treatment-associated health conditions as they age; however, many do not obtain recommended follow-up, putting them at unnecessary risk for morbidity. Educational interventions targeted at providing survivors with the knowledge and skills necessary for healthcare independence might improve adherence and outcomes as they transition care to the adult medical system. OBJECTIVE: To identify informational needs, educational preferences, and support that young adult CCSs perceive as beneficial for transition from pediatric to adult medical care...
April 6, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28360870/the-faculty-of-language-integrates-the-two-core-systems-of-number
#10
Ken Hiraiwa
Only humans possess the faculty of language that allows an infinite array of hierarchically structured expressions (Hauser et al., 2002; Berwick and Chomsky, 2015). Similarly, humans have a capacity for infinite natural numbers, while all other species seem to lack such a capacity (Gelman and Gallistel, 1978; Dehaene, 1997). Thus, the origin of this numerical capacity and its relation to language have been of much interdisciplinary interest in developmental and behavioral psychology, cognitive neuroscience, and linguistics (Dehaene, 1997; Hauser et al...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28324036/vital-directions-and-national-will
#11
EDITORIAL
Donald M Berwick
No abstract text is available yet for this article.
April 11, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28323902/no-prognostic-value-added-by-vitamin-d-pathway-snps-to-current-prognostic-system-for-melanoma-survival
#12
Li Luo, Irene Orlow, Peter A Kanetsky, Nancy E Thomas, Shenying Fang, Jeffrey E Lee, Marianne Berwick, Ji-Hyun Lee
The prognostic improvement attributed to genetic markers over current prognostic system has not been well studied for melanoma. The goal of this study is to evaluate the added prognostic value of Vitamin D Pathway (VitD) SNPs to currently known clinical and demographic factors such as age, sex, Breslow thickness, mitosis and ulceration (CDF). We utilized two large independent well-characterized melanoma studies: the Genes, Environment, and Melanoma (GEM) and MD Anderson studies, and performed variable selection of VitD pathway SNPs and CDF using Random Survival Forest (RSF) method in addition to Cox proportional hazards models...
2017: PloS One
https://www.readbyqxmd.com/read/28323064/the-relevance-of-%C3%AE-klotho-to-the-central-nervous-system-some-key-questions
#13
REVIEW
Marina Minto Cararo-Lopes, Caio Henrique Yokoyama Mazucanti, Cristoforo Scavone, Elisa Mitiko Kawamoto, Daniel Charles Berwick
α-Klotho is well described as an anti-aging protein, with critical roles in kidney function as a transmembrane co-receptor for FGF23, and as a soluble factor in serum. α-Klotho is also expressed in the choroid plexus, where it is released into the cerebrospinal fluid. Nonetheless, α-Klotho is also expressed in the brain parenchyma. Accumulating evidence indicates that this pool of α-Klotho, which we define as brain α-Klotho, may play important roles as a neuroprotective factor and in promoting myelination, thereby supporting healthy brain aging...
March 18, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28271768/at-the-vanguard-of-quality-patient-care
#14
Alison Moore
Don Berwick is a leader in health policy and improvement. He co-founded the Institute for Healthcare Improvement, ran the US Medicaid and Medicare programmes in the early part of Barack Obama's presidency, and was a leading figure in the extension of health insurance to people who struggled to afford it.
March 8, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28103901/pathogenic-lrrk2-variants-are-gain-of-function-mutations-that-enhance-lrrk2-mediated-repression-of-%C3%AE-catenin-signaling
#15
Daniel C Berwick, Behzad Javaheri, Andrea Wetzel, Mark Hopkinson, Jonathon Nixon-Abell, Simone Grannò, Andrew A Pitsillides, Kirsten Harvey
BACKGROUND: LRRK2 mutations and risk variants increase susceptibility to inherited and idiopathic Parkinson's disease, while recent studies have identified potential protective variants. This, and the fact that LRRK2 mutation carriers develop symptoms and brain pathology almost indistinguishable from idiopathic Parkinson's disease, has led to enormous interest in this protein. LRRK2 has been implicated in a range of cellular events, but key among them is canonical Wnt signalling, which results in increased levels of transcriptionally active β-catenin...
January 19, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28077764/antimicrobial-peptide-coatings-for-hydroxyapatite-electrostatic-and-covalent-attachment-of-antimicrobial-peptides-to-surfaces
#16
Leigh Townsend, Richard L Williams, Olachi Anuforom, Matthew R Berwick, Fenella Halstead, Erik Hughes, Artemis Stamboulis, Beryl Oppenheim, Julie Gough, Liam Grover, Robert A H Scott, Mark Webber, Anna F A Peacock, Antonio Belli, Ann Logan, Felicity de Cogan
The interface between implanted devices and their host tissue is complex and is often optimized for maximal integration and cell adhesion. However, this also gives a surface suitable for bacterial colonization. We have developed a novel method of modifying the surface at the material-tissue interface with an antimicrobial peptide (AMP) coating to allow cell attachment while inhibiting bacterial colonization. The technology reported here is a dual AMP coating. The dual coating consists of AMPs covalently bonded to the hydroxyapatite surface, followed by deposition of electrostatically bound AMPs...
January 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28077360/invited-commentary-indoor-tanning-a-melanoma-accelerator
#17
Marianne Berwick, Jean-François Doré
In this issue of the Journal, Ghiasvand et al. (Am J Epidemiol. 2017;185(3):147-156) present results from a longitudinal study of the association between indoor tanning and melanoma in a large cohort of Norwegian women. These new data further support previous findings on the damaging effects of tanning bed exposure on women, particularly young women. The authors present compelling evidence that early exposure to tanning beds advances the date of diagnosis of melanoma by at least 2 years. With a strong design and a large cohort followed for a mean of 13...
February 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28077259/the-growth-of-language-universal-grammar-experience-and-principles-of-computation
#18
REVIEW
Charles Yang, Stephen Crain, Robert C Berwick, Noam Chomsky, Johan J Bolhuis
Human infants develop language remarkably rapidly and without overt instruction. We argue that the distinctive ontogenesis of child language arises from the interplay of three factors: domain-specific principles of language (Universal Grammar), external experience, and properties of non-linguistic domains of cognition including general learning mechanisms and principles of efficient computation. We review developmental evidence that children make use of hierarchically composed structures ('Merge') from the earliest stages and at all levels of linguistic organization...
January 7, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28077229/avoiding-overuse-the-next-quality-frontier
#19
Donald M Berwick
No abstract text is available yet for this article.
January 6, 2017: Lancet
https://www.readbyqxmd.com/read/28074652/trends-in-methyl-tert-butyl-ether-concentrations-in-private-wells-in-southeast-new-hampshire-2005-to-2015
#20
Sarah M Flanagan, Joseph P Levitt, Joseph D Ayotte
In southeast New Hampshire, where reformulated gasoline was used from the 1990s to 2007, methyl tert-butyl ether (MtBE) concentrations ≥0.2 μg/L were found in water from 26.7% of 195 domestic wells sampled in 2005. Ten years later in 2015, and eight years after MtBE was banned, 10.3% continue to have MtBE. Most wells (140 of 195) had no MtBE detections (concentrations <0.2 μg/L) in 2005 and 2015. Of the remaining wells, MtBE concentrations increased in 4 wells, decreased in 47 wells, and did not change in 4 wells...
February 7, 2017: Environmental Science & Technology
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