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https://www.readbyqxmd.com/read/29159363/measuring-patient-safety-in-real-time-an-essential-method-for-effectively-improving-the-safety-of-care
#1
David C Classen, Frances A Griffin, Donald M Berwick
No abstract text is available yet for this article.
November 21, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29145560/strategies-to-achieve-high-value-oncology-care-a-beginning
#2
Harold C Sox, Ethan M Basch, Donald Berwick
No abstract text is available yet for this article.
November 16, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29136441/antipsychotic-drug-prescribing-in-nursing-homes-reply
#3
LETTER
Jerry H Gurwitz, Alice Bonner, Donald M Berwick
No abstract text is available yet for this article.
November 14, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29117386/editorial-when-is-correlation-causation
#4
Marianne Berwick
No abstract text is available yet for this article.
August 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29034804/cip2a-expression-predicts-recurrences-of-tamoxifen-treated-breast-cancer
#5
Shawn Baldacchino, Laura M Wastall, Christian Saliba, Thomas A Hughes, Christian Scerri, Angelene Berwick, Valerie Speirs, Andrew M Hanby, Godfrey Grech
CIP2A is emerging as an oncoprotein overexpressed commonly across many tumours and generally correlated with higher tumour grade and therapeutic resistance. CIP2A drives an oncogenic potential through inhibiting protein phosphatase 2A, stabilizing MYC, and promoting epithelial-to-mesenchymal transition, although further biological mechanisms for CIP2A are yet to be defined. CIP2A protein expression was studied by immunohistochemistry in oestrogen receptor-positive primary breast cancers (n = 250) obtained from the Leeds Tissue Bank...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28990310/the-interaction-between-vitamin-d-receptor-polymorphisms-and-sun-exposure-around-time-of-diagnosis-influences-melanoma-survival
#6
Irene Orlow, Yang Shi, Peter A Kanetsky, Nancy E Thomas, Li Luo, Sergio Corrales-Guerrero, Anne E Cust, Lidia Sacchetto, Roberto Zanetti, Stefano Rosso, Bruce K Armstrong, Terence Dwyer, Alison Venn, Richard P Gallagher, Stephen B Gruber, Loraine D Marrett, Hoda Anton-Culver, Klaus Busam, Colin B Begg, Marianne Berwick
Evidence on the relationship between the vitamin D pathway and outcomes in melanoma is growing, although it is not always clear. We investigated the impact of measured levels of sun exposure at diagnosis on associations of vitamin D receptor gene (VDR) polymorphisms and melanoma death in 3336 incident primary melanoma cases. Interactions between six SNPs and a common 3'-end haplotype were significant (p < .05). These SNPs, and a haplotype, had a statistically significant association with survival among subjects exposed to high UVB in multivariable regression models and exerted their effect in the opposite direction among those with low UVB...
October 9, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28977000/social-group-identity-and-population-substructure-in-admixed-populations-in-new-mexico-and-latin-america
#7
Meghan E Healy, Deirdre Hill, Marianne Berwick, Heather Edgar, Jessica Gross, Keith Hunley
We examined the relationship between continental-level genetic ancestry and racial and ethnic identity in an admixed population in New Mexico with the goal of increasing our understanding of how racial and ethnic identity influence genetic substructure in admixed populations. Our sample consists of 98 New Mexicans who self-identified as Hispanic or Latino (NM-HL) and who further categorized themselves by race and ethnic subgroup membership. The genetic data consist of 270 newly-published autosomal microsatellites from the NM-HL sample and previously published data from 57 globally distributed populations, including 13 admixed samples from Central and South America...
2017: PloS One
https://www.readbyqxmd.com/read/28880417/neuropathology-and-behavioural-features-of-transgenic-murine-models-of-alzheimer-s-disease
#8
Kamar E Ameen-Ali, Stephen B Wharton, Julie E Simpson, Paul R Heath, Paul Sharp, Jason Berwick
Our understanding of the underlying biology of Alzheimer's disease (AD) has been steadily progressing; however, this is yet to translate into a successful treatment in humans. The use of transgenic mouse models has helped to develop our understanding of AD, not only in terms of disease pathology, but also with the associated cognitive impairments typical of AD. Plaques and neurofibrillary tangles are often amongst the last pathological changes in AD mouse models, after neuronal loss and gliosis. There is a general consensus that successful treatments need to be applied before the onset of these pathologies and associated cognitive symptoms...
September 7, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/28842324/associations-of-mc1r-genotype-and-patient-phenotypes-with-braf-and-nras-mutations-in-melanoma
#9
Nancy E Thomas, Sharon N Edmiston, Peter A Kanetsky, Klaus J Busam, Anne Kricker, Bruce K Armstrong, Anne E Cust, Hoda Anton-Culver, Stephen B Gruber, Li Luo, Irene Orlow, Anne S Reiner, Richard P Gallagher, Roberto Zanetti, Stefano Rosso, Lidia Sacchetto, Terence Dwyer, Eloise A Parrish, Honglin Hao, David C Gibbs, Jill S Frank, David W Ollila, Colin B Begg, Marianne Berwick, Kathleen Conway
Associations of MC1R with BRAF mutations in melanoma have been inconsistent between studies. We sought to determine for 1,227 participants in the international population-based Genes, Environment, and Melanoma (GEM) study whether MC1R and phenotypes were associated with melanoma BRAF/NRAS subtypes. We used logistic regression adjusted by age, sex, and study design features and examined effect modifications. BRAF(+) were associated with younger age, blond/light brown hair, increased nevi, and less freckling, and NRAS(+) with older age relative to the wild type (BRAF(-)/NRAS(-)) melanomas (all P < 0...
August 24, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28746718/association-of-incident-amelanotic-melanoma-with-phenotypic-characteristics-mc1r-status-and-prior-amelanotic-melanoma
#10
Steven Vernali, Weston T Waxweiler, Patrick M Dillon, Peter A Kanetsky, Irene Orlow, Li Luo, Klaus J Busam, Anne Kricker, Bruce K Armstrong, Hoda Anton-Culver, Stephen B Gruber, Richard P Gallagher, Roberto Zanetti, Stefano Rosso, Lidia Sacchetto, Terence Dwyer, Anne E Cust, David W Ollila, Colin B Begg, Marianne Berwick, Nancy E Thomas
Importance: We previously reported that survival is poorer from histopathologically amelanotic than pigmented melanoma because of more advanced stage at diagnosis. Identifying patients at risk of amelanotic melanoma might enable earlier diagnosis and improved survival; however, the phenotypic characteristics and underlying genetics associated with amelanotic melanoma are unknown. Objective: To determine whether phenotypic characteristics, carriage of MC1R variants, and history of amelanotic melanoma are associated with histopathologically amelanotic melanoma...
October 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28617907/reducing-excessive-use-of-antipsychotic-agents-in-nursing-homes
#11
Jerry H Gurwitz, Alice Bonner, Donald M Berwick
No abstract text is available yet for this article.
July 11, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28617013/the-role-of-policy-in-supporting-clinician-led-research-on-behavioral-health-integration
#12
Nathaniel Z Counts
In Best Care at Lower Cost, the Institute of Medicine laid out a vision for continuously learning health systems (Institute of Medicine of the National Academies, 2016). This issue of Families, Systems, & Health represents a substantial step toward this vision, with on-the-ground clinicians and administrators testing empirically informed hypotheses about practice transformation and population health management, and using those results to produce shared learning within and across systems. While the studies in this issue demonstrate that producing generalizable knowledge from clinician-led initiatives is feasible, they also demonstrate that the current system does not adequately support clinicians in doing so...
June 2017: Families, Systems & Health: the Journal of Collaborative Family Healthcare
https://www.readbyqxmd.com/read/28592416/understanding-the-american-healthcare-reform-debate
#13
Donald M Berwick
No abstract text is available yet for this article.
June 7, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28494491/topical-delivery-of-anti-vegf-drugs-to-the-ocular-posterior-segment-using-cell-penetrating-peptides
#14
Felicity de Cogan, Lisa J Hill, Aisling Lynch, Peter J Morgan-Warren, Judith Lechner, Matthew R Berwick, Anna F A Peacock, Mei Chen, Robert A H Scott, Heping Xu, Ann Logan
Purpose: To evaluate the efficacy of anti-VEGF agents for treating choroidal neovascularization (CNV) when delivered topically using novel cell-penetrating peptides (CPPs) compared with delivery by intravitreal (ivit) injection. Methods: CPP toxicity was investigated in cell cultures. Ivit concentrations of ranibizumab and bevacizumab after topical administration were measured using ELISA. The biological efficacy of topical anti-VEGF + CPP complexes was compared with ivit anti-VEGF injections using an established model of CNV...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28483192/no-association-between-influenza-vaccination-during-pregnancy-and-adverse-birth-outcomes
#15
Ousseny Zerbo, Sharareh Modaressi, Berwick Chan, Kristin Goddard, Ned Lewis, Karin Bok, Bruce Fireman, Nicola P Klein, Roger Baxter
BACKGROUND: Pregnant women are recommended to receive inactivated influenza vaccination anytime during pregnancy. Studies have investigated the impact of influenza vaccination during pregnancy on birth outcomes and results on preterm birth have been inconsistent. METHODS: We conducted a retrospective cohort study among children born at a gestational age≥24weeks from January 1, 2010 to December 31, 2015 at Kaiser Permanente Northern California facilities (KPNC)...
May 31, 2017: Vaccine
https://www.readbyqxmd.com/read/28448652/breaking-the-rules-for-better-care
#16
Donald M Berwick, Saranya Loehrer, Christina Gunther-Murphy
No abstract text is available yet for this article.
June 6, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28442450/implementing-an-internet-delivered-skin-cancer-genetic-testing-intervention-to-improve-sun-protection-behavior-in-a-diverse-population-protocol-for-a-randomized-controlled-trial
#17
Jennifer L Hay, Marianne Berwick, Kate Zielaskowski, Kirsten Am White, Vivian M Rodríguez, Erika Robers, Dolores D Guest, Andrew Sussman, Yvonne Talamantes, Matthew R Schwartz, Jennie Greb, Jessica Bigney, Kimberly A Kaphingst, Keith Hunley, David B Buller
BACKGROUND: Limited translational genomic research currently exists to guide the availability, comprehension, and appropriate use of personalized genomics in diverse general population subgroups. Melanoma skin cancers are preventable, curable, common in the general population, and disproportionately increasing in Hispanics. OBJECTIVE: Variants in the melanocortin-1 receptor (MC1R) gene are present in approximately 50% of the population, are major factors in determining sun sensitivity, and confer a 2-to-3-fold increase in melanoma risk in the general population, even in populations with darker skin...
April 25, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28383822/preparing-childhood-cancer-survivors-for-transition-to-adult-care-the-young-adult-perspective
#18
Natasha N Frederick, Sharon L Bober, Lexie Berwick, Mary Tower, Lisa B Kenney
BACKGROUND: Childhood cancer survivors (CCSs) remain at risk for developing treatment-associated health conditions as they age; however, many do not obtain recommended follow-up, putting them at unnecessary risk for morbidity. Educational interventions targeted at providing survivors with the knowledge and skills necessary for healthcare independence might improve adherence and outcomes as they transition care to the adult medical system. OBJECTIVE: To identify informational needs, educational preferences, and support that young adult CCSs perceive as beneficial for transition from pediatric to adult medical care...
October 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28360870/the-faculty-of-language-integrates-the-two-core-systems-of-number
#19
Ken Hiraiwa
Only humans possess the faculty of language that allows an infinite array of hierarchically structured expressions (Hauser et al., 2002; Berwick and Chomsky, 2015). Similarly, humans have a capacity for infinite natural numbers, while all other species seem to lack such a capacity (Gelman and Gallistel, 1978; Dehaene, 1997). Thus, the origin of this numerical capacity and its relation to language have been of much interdisciplinary interest in developmental and behavioral psychology, cognitive neuroscience, and linguistics (Dehaene, 1997; Hauser et al...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28324036/vital-directions-and-national-will
#20
EDITORIAL
Donald M Berwick
No abstract text is available yet for this article.
April 11, 2017: JAMA: the Journal of the American Medical Association
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