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https://www.readbyqxmd.com/read/28915287/efficacy-and-safety-of-desoximetasone-0-25-spray-in-adult-atopic-dermatitis-subjects-pilot-study
#1
Lauren K Hoffman, Leon Kircik
BACKGROUND: Atopic dermatitis (AD) is a chronic, relapsing, inflammatory skin disorder. One of the most disturbing symptoms of AD is pruritus. The first line treatment for AD is topical corticosteroids, topical immunomodulators, topical barrier creams, oral antihistamines, and systemic treatments. Desoximetasone 0.25% spray is a superpotent topical corticosteroid delivered in a novel way and it may be a suitable option for the treatment of pruritus in adult atopic dermatitis patients...
September 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28905999/validation-of-patient-reported-global-severity-of-atopic-dermatitis-in-adults
#2
Paras P Vakharia, Rishi Chopra, Ryan Sacotte, Neha Patel, Supriya Immaneni, Takeshia White, Robert Kantor, Derek Y Hsu, Jonathan I Silverberg
BACKGROUND: Atopic dermatitis (AD) is associated with a heterogeneous presentation and clinical course. There is a lack of simple and validated severity assessments that are feasible for clinical practice and epidemiological research. OBJECTIVES: We sought to validate patient-reported global AD severity in adults. METHODS: We performed a prospective dermatology practice-based study using questionnaires and evaluation by a dermatologist (n=265)...
September 14, 2017: Allergy
https://www.readbyqxmd.com/read/28884989/hydroxychloroquine-in-the-treatment-of-anti-histamine-refractory-chronic-spontaneous-urticaria-randomized-single-blinded-placebo-controlled-trial-and-an-open-label-comparison-study
#3
T Boonpiyathad, A Sangasapaviliya
Background. The management of anti-histamine refractory chronic spontaneous urticaria (CSU) has poorly defined therapeutic options. Some patients with CSU respond poorly to a fourfold increase in dosage of H1-anti-histamines treatment. Aim. The objective of this study was to determine the effect of an adjunct treatment of hydroxychloroquine (HCQ) on remission rate and reduction of urticarial symptoms. Methods. Sixty subjects with anti-histamine refractory CSU were randomly assigned to 400 mg of HCQ daily or placebo for 12 weeks in a single blind placebo controlled trial...
September 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28877373/prevalence-of-onychomycosis-among-patients-with-nail-psoriasis-who-are-not-receiving-immunosuppressive-agents-results-of-a-pilot-study
#4
Aikaterini Tsentemeidou, Timoleon-Achilleas Vyzantiadis, Aikaterini Kyriakou, Dimitrios Sotiriadis, Aikaterini Patsatsi
Nail psoriasis and onychomycosis can often be hard to differentiate clinically and may coexist, complicating each other's course. The aim of this study was to determine the prevalence of onychomycosis among patients with nail psoriasis not being treated with immunosuppressive agents, which constitute an independent risk factor for fungal infections. A cross-sectional study was performed. All adult patients with nail psoriasis who were not receiving antifungal and/or immunosuppressive treatment were recruited at the 2nd University Dermatology Department of Aristotle University of Thessaloniki from 10/2016 till 02/2017...
September 6, 2017: Mycoses
https://www.readbyqxmd.com/read/28875430/measurement-properties-of-the-eq-5d-5l-compared-to-the-eq-5d-3l-in-psoriasis-patients
#5
Adrienn Katalin Poór, Fanni Rencz, Valentin Brodszky, László Gulácsi, Zsuzsanna Beretzky, Bernadett Hidvégi, Péter Holló, Sarolta Kárpáti, Márta Péntek
The purpose of this study is to assess the measurement properties of EQ-5D-5L compared to EQ-5D-3L in psoriasis patients. METHODS: A cross-sectional survey was carried out at an academic dermatology clinic in Hungary. Psoriasis patients completed the EQ-5D-3L, EQ-5D-5L and Dermatology Life Quality Index (DLQI) questionnaires, and Psoriasis Area and Severity Index (PASI) was assessed. The UK value sets were used to calculate the 3L and 5L index scores. We tested the feasibility, ceiling effect, redistribution properties, the level of inconsistency and informativity (Shannon and Shannon Evenness indices)...
September 5, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28871926/translation-and-validation-of-the-serbian-version-of-the-skindex-29-instrument-for-measuring-impact-of-skin-disease-on-quality-of-life
#6
Jelena D Milutinović, Nebojša Krstić, Slobodan M Janković
The Skindex-29 instrument, which is intended for measuring the influence of skin diseases on quality of life, was developed and validated in several languages. However, a Serbian translation of the instrument is not available. The aim of this study was to translate the Skindex-29 from English to Serbian, to make necessary cultural adaptations, and to test its psychometric properties in a sample of outpatients with various skin diseases. The Skindex-29 was translated and adapted according to internationally accepted guidelines and then tested on a sample of Serbian outpatients with various skin diseases...
July 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28862892/chronic-leg-ulcers-disrupt-patients-lives-a-study-of-leg-ulcer-related-life-changes-and-quality-of-life
#7
Nélia Cunha, Sara Campos, Joana Cabete
Chronic leg ulcers have a profound impact on patients' physical, functional, and psychological status, which may result in several life changes and a significant decline in quality of life (QoL). We aimed to study what changed in patients' lives after developing a chronic leg ulcer, including QoL, patients' comprehension of the disease and related feelings. A cross-sectional study, using an anonymous questionnaire and the Dermatology Life Quality Index (DLQI) was performed. Chronic leg ulcers were life changing events, causing abandonment of work in almost 80% of the patients and important limitations in daily activities and autonomy...
September 1, 2017: British Journal of Community Nursing
https://www.readbyqxmd.com/read/28833787/efficacy-of-a-global-supportive-skin-care-programme-with-hydrotherapy-after-non-metastatic-breast-cancer-treatment-a%C3%A2-randomised-controlled-study
#8
F Dalenc, V Ribet, A B Rossi, J Guyonnaud, C Bernard-Marty, B de Lafontan, S Salas, A-L Ranc Royo, C Sarda, N Levasseur, C Massabeau, J-M Levecq, P Dulguerova, D Guerrero, V Sibaud
This study investigated the efficacy of post-treatment hydrotherapy as supportive care for management of persistent/long-lasting dermatologic adverse events (dAEs) induced in breast cancer survivors by adjuvant therapy, and its impact on quality of life (QoL). Patients in complete remission after standardised (neo)adjuvant chemotherapy, surgery and radiotherapy combination treatment for infiltrating HR+/HER2-breast carcinoma were enrolled in this randomised, multicentre controlled study 1-5 weeks after completing radiotherapy...
August 22, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28831246/general-quality-of-life-of-patients-with-acne-vulgaris-before-and-after-performing-selected-cosmetological-treatments
#9
Karolina Chilicka, Joanna Maj, Bernard Panaszek
BACKGROUND: Achieving a satisfying quality of life for a patient by applying individually matched therapy is, simultaneously, a great challenge and a priority for contemporary medicine. Patients with visible dermatological ailments are particularly susceptible to reduction in the general quality of life. Among the dermatological diseases, acne causes considerable reduction in the quality of life and changes in self-perception that lead to the worsening of a patient's mental condition, including depression and suicidal thoughts...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28797188/validation-of-psychometric-properties-and-development-of-response-criteria-for-the-psoriasis-symptoms-and-signs-diary-pssd-results-from-a-phase-iii-clinical-trial
#10
April Armstrong, Luis Puig, Richard Langley, Tsen Fang Tsai, Michael Song, Yasmine Wasfi, Jingzhi Jiang, Shu Li, Chenglong Han
PURPOSE: The Psoriasis Symptoms and Signs Diary (PSSD) is a patient-reported instrument that assesses severity of six psoriasis symptoms (itch, skin tightness, burning, stinging, and pain,) and five signs (dryness, cracking, scaling, shedding/flaking, redness, and bleeding). MATERIALS AND METHODS: PSSD symptoms and signs summary scores (0-100) were derived based on individual item scores (0-10 [absent-worst imaginable]). Using Psoriasis Area and Severity Index [PASI], Investigator's Global Assessment [IGA] and Dermatology Life Quality Index [DLQI]) data from the NAVIGATE trial of patients with moderate-to-severe psoriasis, analyses were conducted to further validate the PSSD (7-day recall version) and establish criteria for clinically meaningful improvements (CMIs)...
August 11, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28797174/the-dermatology-life-quality-index-dlqi-and-the-hospital-anxiety-and-depression-hads-in-chinese-rosacea-patients
#11
Yanyu Wu, Chaowei Fu, Wei Zhang, Caixia Li, Jie Zhang
The study aims to investigate the quality of life (QOL) and the psychological situation in Chinese patients with rosacea. A total of 196 healthy controls and 201 rosacea patients were involved in the final analysis. The general information, the Dermatology Life Quality Index (DLQI) and the Hospital Anxiety and Depression Scale (HADS) were collected. Significantly higher DLQI, anxiety and depression score were observed in the rosacea group compared to the control group (p < .01). Total DLQI score of patients was positively related with anxiety (r = ...
August 10, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28796910/factors-predicting-the-self-evaluated-health-of-hidradenitis-suppurativa-patients-recruited-from-an-outpatient-clinic
#12
R Kjaersgaard Andersen, P Theut Riis, G B E Jemec
OBJECTIVES: In recent years, Hidradenitis suppurativa has received increased attention, but still lack well-defined, robust patient reported outcome measures. Such measures are likely to be influenced by contextual factors. We therefore aim to describe the association of biological and other factors with HS patient's self-evaluated health as reflected by the EQ5D VAS score. METHODS: This cross-sectional study measured basic information, Dermatology Life Quality Index, Major Depression Inventory, and Euro-QoL-5D...
August 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28795763/determinants-of-psychosocial-health-in-psoriatic-patients-a-multi-national-study
#13
Karolina Lesner, Adam Reich, Jacek C Szepietowski, Florence J Dalgard, Uwe Gieler, Lucía Tomas-Aragones, Lars Lien, Françoise Poot, Gregor B Jemec, Laurent Misery, Csanád Szabó, Dennis Linder, Francesca Sampogna, Andrea W M Evers, Jon Anders Halvorsen, Flora Balieva, Andrey Lvov, Servando E Marron, Ilknur K Altunay, Andrew Y Finlay, Sam S Salek, Jörg Kupfer
There are limited data on the differences in the impact of psoriasis between various countries with respect to quality of life (QoL). The aim of this study was to explore the psychosocial health of patients with psoriasis in different European countries. A total of 682 patients were recruited in 13 European countries. All patients completed a questionnaire regarding socio-demographic information, negative life events, suicidal ideation and satisfaction with their dermatologist. Depression and anxiety were assessed with the Hospital Anxiety and Depression Scale (HADS), and QoL with the Dermatology Life Quality Index (DLQI) and EuroQoL (EQ-5D)...
August 10, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28777015/is-weekly-dose-of-adalimumab-a-simple-approach-for-resistant-psoriasis
#14
Sara Mazzilli, Arianna Zangrilli, Mauro Bavetta, Luca Bianchi
Backgroud: In real life, dose escalation can be a good approach for increasing efficacy in a subgroup of patients with an insufficient response to biologic therapy, reducing the signs and symptoms of psoriasis and improving the quality of life (QOL). OBJECTIVE: To determine the effectiveness of escalating adalimumab dosage from 40 mg eow to 40 mg weekly in a patient affected by psoriasis (PsO) and psoriatic arthritis (PsA) with < PASI 50 response following 364 weeks treatment...
August 4, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28771657/time-pasi-and-dlqi-of-psoriasis-patients-who-drop-out-of-clinical-trials-on-etanercept-due-to-lack-of-efficacy-a-pooled-analysis-from-ten-clinical-trials
#15
A Nast, M Dilleen, W Liyanage, L Aikman, P Szczypa, C Dressler
BACKGROUND: Patient-reported outcomes in psoriasis studies are assessed at specific study time points. If a treatment has not become effective by a certain time point, it may increase the likelihood of patients being dissatisfied and leaving a clinical study. OBJECTIVES: Generate evidence concerning the number of patients dropping out of etanercept trials over time including PASI and DLQI data. METHODS: Data from psoriasis patients in ten trials with etanercept were pooled...
August 3, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28762236/conceptualisation-development-and-validation-of-t-qol%C3%A2-teenagers-quality-of-life-a-patient-focused-measure-to-assess-quality-of-life-of-adolescents-with-skin-diseases
#16
M K A Basra, M S Salek, D Fenech, A Y Finlay
AIM: To develop and validate a dermatology-specific quality of life (QoL) instrument for adolescents with skin diseases. METHODS: Qualitative semi-structured interviews were conducted with adolescents with skin disease to gain in-depth understanding of how skin diseases affect their QoL. A prototype instrument based on the themes identified from content analysis of interviews was tested in several stages, using Classical Test Theory (CTT) and Item Response Theory (IRT) models to develop this new tool and conduct its psychometric evaluation...
July 31, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28761839/a-real-world-study-to-assess-the-effectiveness-of-itolizumab-in-patients-with-chronic-plaque-psoriasis
#17
Anchala Parthasaradhi, Vinay Singh, S G Parasramani, Nishi Yadav, D S Krupashankar, Manish Soni, Rakesh Bansal
BACKGROUND: While clinical trial data on the efficacy of itolizumab in the management of psoriasis is relatively well documented, data on the effectiveness of this humanized IgG1 monoclonal antibody in real-world settings is sparse. AIMS: The current study assessed the effectiveness of itolizumab in real-world settings. MATERIALS AND METHODS: This study assessed psoriasis area severity index (PASI), dermatology quality of life index (DLQI), safety, and tolerability data from a registry of itolizumab maintained by Syngene International, Bangalore...
July 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28761295/the-clinical-profile-of-patients-with-psoriasis-in-korea-a-nationwide-cross-sectional-study-epi-psode
#18
Hae Jun Song, Chul Jong Park, Tae Yoon Kim, Yong Beom Choe, Seok-Jong Lee, Nack In Kim, Jae We Cho, Jie Hyun Jeon, Min Soo Jang, Jai Il Youn, Myung Hwa Kim, Joonsoo Park, Ki Ho Kim, Byung Soo Kim, Sang Woong Youn, Joo-Heung Lee, Min-Geol Lee, Sung Ku Ahn, Young Ho Won, Seok Kweon Yun, Bong Seok Shin, Seong Jun Seo, Ji Yeoun Lee, Kwang Joong Kim, Young Suck Ro, Youngdoe Kim, Dae Young Yu, Jee-Ho Choi
BACKGROUND: Psoriasis is an immune-mediated, chronic inflammatory disease affecting multiple aspects of patients' lives. Its epidemiology varies regionally; however, nationwide epidemiologic data on psoriasis depicting profile of Korean patients has not been available to date. OBJECTIVE: To understand nationwide epidemiologic characteristics and clinical features of adult patients with psoriasis visited university hospitals in Korea. METHODS: This multicenter, non-interventional, cross-sectional study recruited 1,278 adult patients with psoriasis across 25 centers in Korea in 2013...
August 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28738881/assessment-of-quality-of-life-in-patients-with-post-kalaazar-dermal-leishmaniasis
#19
Biplab Pal, Krishna Murti, Niyamat Ali Siddiqui, Pradeep Das, Chandra Shekhar Lal, Rajendra Babu, Manoj Kumar Rastogi, Krishna Pandey
BACKGROUND: Post kala-azar dermal leishmaniasis (PKDL) is a dermatological disorder caused by protozoal parasite Leishmania donovani. PKDL cases are thought to be a reservoir of parasites and may increase cases of visceral leishmaniasis. The disease is not life threatening but cosmetic disfigurement associated with it may impair the patients' quality of life. This study aimed to assess the health related quality of life in patients with post kalaazar dermal leishmanasis for the first time...
July 24, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28735828/investigation-of-dietary-supplements-prevalence-as-complementary-therapy-comparison-between-hospitalized-psoriasis-patients-and-non-psoriasis-patients-correlation-with-disease-severity-and-quality-of-life
#20
COMPARATIVE STUDY
Hadis Yousefzadeh, Mahmoud Mahmoudi, Mahnaz Banihashemi, Maryam Rastin, Farahzad Jabbari Azad
OBJECTIVES: Psoriasis patients are often displeased with traditional medical treatments and they may self-prescribe dietary supplements as an alternative or complementary treatments. We aimed to investigate the prevalence of self-medication of dietary supplements among psoriasis and non-psoriasis cases and its impact on disease severity and quality of life. DESIGN AND SETTING: This case-control study evaluated 252 records of psoriasis patients and 245 non-psoriasis cases...
August 2017: Complementary Therapies in Medicine
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