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https://www.readbyqxmd.com/read/29130488/crp-is-linked-to-disease-activity-impact-and-response-to-treatment-in-patients-with-chronic-spontaneous-urticaria
#1
Pavel Kolkhir, Sabine Altrichter, Tomasz Hawro, Marcus Maurer
BACKGROUND: Elevated levels of C-reactive protein (CRP), a sensitive marker of inflammation, have been consistently reported in chronic spontaneous urticaria. Here, we retrospectively analyzed data from 1,253 CSU patients from two centers to answer the following questions: 1) What is the prevalence of elevated levels of CRP in CSU? 2) Why do CSU patients show elevated levels of CRP? 3) Are elevated CRP levels relevant? METHODS: Serum levels of CRP were measured by the nephelometric method...
November 12, 2017: Allergy
https://www.readbyqxmd.com/read/29128966/is-the-dlqi-appropriate-for-medical-decision-making-in-psoriasis-patients
#2
Adrienn Katalin Poór, Valentin Brodszky, Márta Péntek, László Gulácsi, Gábor Ruzsa, Bernadett Hidvégi, Péter Holló, Sarolta Kárpáti, Miklós Sárdy, Fanni Rencz
Dermatology Life Quality Index (DLQI) is the most commonly applied measure of health-related quality of life (HRQoL) in psoriasis patients. It is among defining criteria of moderate-to-severe psoriasis and present in treatment guidelines. Our objective was to estimate preference-based HRQoL values (i.e., utilities) for hypothetical health states described by the 10 items of the DLQI in psoriasis patients. Moreover, we compare results to findings of a similar study previously conducted among the general public...
November 11, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29114942/a-detailed-analysis-of-not-relevant-responses-on-the-dlqi-in-psoriasis-potential-biases-in-treatment-decisions
#3
F Rencz, A K Poór, M Péntek, P Holló, S Kárpáti, L Gulácsi, A Szegedi, É Remenyik, B Hidvégi, K Herszényi, H Jókai, Z Beretzky, V Brodszky
BACKGROUND: Dermatology Life Quality Index (DLQI) is the most common health-related quality of life measure in dermatology that is widely used in treatment guidelines for psoriasis. Eight out of the 10 questions of the DLQI offer a 'not relevant' response (NRR) option that is scored as the item had no impact on patients' life at all. OBJECTIVE: To explore the occurrence of NRRs on the DLQI in psoriasis patients, and to examine the effect of several socio-demographic and clinical factors on giving NRRs...
November 8, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29114862/fumaric-acid-esters-in-combination-with-a-6-week-course-of-narrow-band-uvb-provides-for-an-accelerated-response-as-compared-to-fumaric-acid-esters-monotherapy-in-patients-with-moderate-to-severe-plaque-psoriasis-a-randomized-prospective-clinical-study
#4
S Tzaneva, A Geroldinger, H Trattner, A Tanew
BACKGROUND: Fumaric acid esters are (FAE) safe and effective in patients with moderate to severe psoriasis but have a slow onset of action. A short-term combination with narrow-band UVB (NB UVB) may substantially accelerate the therapeutic response in the induction phase of treatment. OBJECTIVES: To assess the synergistic effect of a 6-week course of NB UVB phototherapy in addition to fumaric acid esters in adult patients with moderate to severe plaque psoriasis...
November 8, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29110877/impact-on-quality-of-life-in-dermatology-patients-attending-an-emergency-department
#5
A Alegre-Sánchez, D de Perosanz-Lobo, A Pascual-Sánchez, C Pindado-Ortega, P Fonda-Pascual, Ó M Moreno-Arrones, P Jaén-Olasolo
INTRODUCTION: Dermatological complaints have been estimated to represent up to 5-10% of all the visits to emergency departments. The main objective of our study was to determine how affected is the Health related Quality of Life (HRQL) in a series of patients attending an emergency department due to skin symptoms. PATIENTS AND METHODS: A prospective study during one month (July 2016) was conducted in a hospital with full-time on-call dermatologists. The Short-Form SF-12v2 Health Survey and the Dermatology Life Quality Index (DLQI) were offered to all the patients over 18 years old attending the emergency department with cutaneous complaints...
October 28, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29110042/-acne-inversa-hidradenitis-suppurativa-a%C3%A2-challenge-for-the-future
#6
REVIEW
R Sabat
Acne inversa (AI)/hidradenitis suppurativa is a chronic recurrent inflammatory dermatosis with signs of a systemic disease. AI is characterized by typical skin alterations in body areas bearing apocrine glands. The care of the AI patients in Germany is still inadequate. This situation might be significantly improved through the following efforts: (i) shortening of the time between the disease onset and the diagnosis/start of therapy; (ii) the in-depth investigation of AI pathogenesis with the aim of identifying innovative therapeutic targets and blood biomarkers; (iii) establishing a method for quantifying the severity of the disease, which takes into account both the clinical assessment and objective laboratory parameters and the self-assessment of the patient (e...
November 6, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29110019/correlation-between-dermatology-life-quality-index-and-psoriasis-area-and-severity-index-in-patients-with-psoriasis-treated-with-ustekinumab
#7
Jeanette Halskou Hesselvig, Alexander Egeberg, Nikolai Dyrberg Loft, Claus Zachariae, Kristian Kofoed, Lone Skov
Biologic treatment for psoriasis is based on clinical evaluation and patient's quality of life. However, long-term correlation between Psoriasis Area and Severity Index (PASI) and Dermatology Life Quality Index (DLQI) in real life has not been studied in patients treated with ustekinumab. All patients with psoriasis treated with ustekinumab at our department were included (n = 120) in this study. Correlation analyses between the change in PASI and DLQI and the individual subquestions in DLQI were performed using Spearman's rank correlation coefficient...
November 7, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29106018/quality-of-life-assessment-in-patients-with-nonmelanoma-skin-cancer-psychometric-validation-of-the-eortc-qlq-c30-questionnaire
#8
Karolina Müller, Sigrid Karrer, Rolf-Markus Szeimies, Julia Steinbauer, Elisabeth Kohl, Dominik Steinbauer, Florian Zeman, Mark Berneburg, Michael Koller
BACKGROUND: Nonmelanoma skin cancer (NMSC) is a chronic and sometimes difficult-to-treat condition affecting the quality of life (QL). The present study was conducted to investigate whether the European Organization for Research and Treatment of Cancer (EORTC) core QL Questionnaire - Cancer (QLQ-C30) is a suitable tool for the assessment of QL in patients with NMSC. PATIENTS AND METHODS: In order to define the psychometric properties of the questionnaire, the QLQ-C30 and the Dermatology Life Quality Index (DLQI) were handed out to 172 patients of the Department of Dermatology at the University Hospital Regensburg, Germany...
November 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29098911/targeted-treatments-for-hidradenitis-suppurativa-a-review-of-the-current-literature-and-ongoing-clinical-trials
#9
Melody Maarouf, Ashley K Clark, Dylan E Lee, Vivian Y Shi
PURPOSE: Targeted, immune-modulating drugs are at the forefront of therapy for HS, and a comprehensive clinical trial registry is needed to facilitate data pooling and clinical efficacy comparison. MATERIALS AND METHODS: A systematic review of the ClinicalTrials.gov database was searched for planned, in-progress, completed, or terminated trials investigating the effect of targeted biologic therapies for hidradenitis suppurativa (HS). When results of RCTs were not available, case reports or series were included...
November 10, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29098154/12-item-pruritus-severity-scale-development-and-validation-of-new-itch-severity-questionnaire
#10
Adam Reich, Agnieszka Bożek, Katarzyna Janiszewska, Jacek C Szepietowski
Introduction: A validated assessment of pruritus intensity is an important but still difficult clinical problem due to a subjective nature of this sensation. Objective: The aim of this study was the creation and validation of new itch severity questionnaire assessing pruritus intensity. Material and Methods: A total of 148 patients with pruritic dermatoses were asked to assess pruritus intensity using 12-Item Pruritus Severity Score (12-PSS) and Visual Analogue Scale (VAS)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29095653/curcuma-longa-turmeric-for-prevention-of-capecitabine-induced-hand-foot-syndrome-a-pilot-study
#11
Vanessa Armenio Scontre, Janine Capobiango Martins, Claudia Vaz de Melo Sette, Haila Mutti, Daniel Cubero, Fernando Fonseca, Auro Del Giglio
Hand-foot syndrome (HFS) is common and frequently occurs in the first cycle of treatment in approximately 40% to 50% of patients who receive capecitabine. Turmeric (Curcuma longa) is a plant used in Ayurvedic medicine with clinical activity in various inflammatory conditions. Our objective was to evaluate whether turmeric was active for the prevention of capecitabine-induced HFS. We included patients older than 18 years of age without previous exposure to capecitabine who were scheduled to receive this medication...
November 2, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29089786/can-laser-treatment-improve-quality-of-life-of-hirsute-women
#12
Narges Alizadeh, Sharad Ayyoubi, Mohammadreza Naghipour, Rasool Hassanzadeh, Zahra Mohtasham-Amiri, Shirin Zaresharifi, Kaveh Gharaei Nejad
BACKGROUND: Hirsutism can have negative impacts on psychosocial aspects of women's lives and reduce their quality of life (QOL). The aim of this study was to assess the QOL of these women during laser treatment. PATIENTS AND METHODS: Eighty-eight women with unwanted facial hair underwent laser therapy. Each patient completed a questionnaire consisting of a modified Dermatology Life Quality Index (DLQI) and visual analog scale (VAS) before the first, third, and fifth sessions of laser therapy...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/29080008/objective-evaluation-of-the-efficacy-of-a-non-ablative-fractional-1565%C3%A2-nm-laser-for-the-treatment-of-deliberate-self-harm-scars
#13
Anne Guertler, Markus Reinholz, Julian Poetschke, Stephanie Steckmeier, Hannah Schwaiger, Gerd G Gauglitz
Scars resulting from deliberate self-harm (DSH) represent therapeutically challenging forms of scarring due to their highly variable patterns, with no official therapeutic guidelines available. In this pilot study, we aimed to evaluate the effectiveness and safety of a non-ablative fractional Er:glass 1565 nm laser, as a potential new, minimal-invasive approach for the improvement of DSH scars. Sixteen Caucasians suffering from mature DSH scars were included in this clinical study. Patients received a total of three treatments using a non-ablative fractional 1565 nm Er:glass laser every 4 weeks, employing two passes (300 μbeams/cm(2), 40 mJ, onto the scar; 150 μbeams/cm(2), 50 mJ, overall area)...
October 27, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29078013/job-change-facilitates-healing-in-a-cohort-of-patients-with-occupational-hand-eczema
#14
T K Carøe, N E Ebbehøj, J P E Bonde, S G Vejlstrup, T Agner
BACKGROUND: Occupational hand eczema is a frequent and often chronic disease and knowledge of the consequences of change of profession is sparse. OBJECTIVES: To compare severity of hand eczema and health related QoL HR-QoL in patients who after 5 years were still in the same profession and those who were not. METHODS: The study is a register-based cohort study including patients with recognised occupational hand eczema in Denmark in 2010 and 2011...
October 27, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29066271/effect-of-secukinumab-on-quality-of-life-and-psoriasis-related-symptoms-a-comparative-analysis-versus-ustekinumab-from-the-clear-52-week-study
#15
Lluís Puig, Matthias Augustin, Andrew Blauvelt, Alice B Gottlieb, Ron Vender, Neil J Korman, Diamant Thaçi, Yang Zhao, Isabelle Gilloteau, Bintu Sherif, Nicole Williams, Adriana Guana, Mark G Lebwohl
BACKGROUND: Secukinumab has demonstrated greater sustained skin clearance versus ustekinumab through Week 52, greater improvement in symptoms and health-related quality of life (HRQOL), and comparable safety profile. OBJECTIVE: To assess the impact of secukinumab versus ustekinumab on complete relief from psoriasis-related symptoms, time to HRQOL response, and cumulative benefit among patients with moderate-to-severe plaque psoriasis. METHODS: Psoriasis-related pain, itching, and scaling and the Dermatology Life Quality Index (DLQI) were compared between treatments based on time to complete relief of symptoms and to DLQI response in the CLEAR trial...
October 21, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29058822/omalizumab-rapidly-improves-angioedema-related-quality-of-life-in-adult-patients-with-chronic-spontaneous-urticaria-x-act-study-data
#16
Petra Staubach, Martin Metz, Nadine Chapman-Rothe, Christian Sieder, Matthias Bräutigam, Marcus Maurer, Karsten Weller
BACKGROUND: The X-ACT study aims to examine the effect of omalizumab treatment on quality of life (QoL) in chronic spontaneous urticaria (CSU) patients with angioedema refractory to high doses of H1 -antihistamines. METHODS: In X-ACT, a phase III, double-blind, placebo-controlled study, CSU patients (18-75 years) with ≥4 angioedema episodes during the 6 months before inclusion were randomized (1:1) to receive omalizumab 300 mg or placebo every 4 weeks for 28 weeks...
October 23, 2017: Allergy
https://www.readbyqxmd.com/read/29048751/severity-strata-for-five-patient-reported-outcomes-in-adults-with-atopic-dermatitis
#17
P P Vakharia, R Chopra, R Sacotte, N Patel, S Immaneni, T White, R Kantor, D Y Hsu, E L Simpson, J I Silverberg
BACKGROUND: Multiple patient-reported outcomes have been used to assess the burden of atopic dermatitis (AD). Some are disease specific, e.g. the Patient Oriented Eczema Measure (POEM). While others pertain to itch, e.g. Numerical Rating Scale (NRS)-itch, ItchyQoL and 5-D itch, or dermatologic disease in general, e.g. Dermatology Life Quality Index (DLQI). Development of severity strata is essential for proper interpretability of these assessments. We sought to confirm previously developed strata for POEM, DLQI and raw ItchyQoL, and develop strata for the NRS-itch, mean ItchyQOL and 5-D itch scale for use in adults with AD...
October 19, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29047198/evaluation-of-narrow-band-ultraviolet-b-phototherapy-in-the-treatment-of-chronic-actinic-dermatitis-in-chinese-patients
#18
Li Ma, Qiaoan Zhang, Yue Hu, Xiaoqun Luo
Few studies have been conducted in chronic actinic dermatitis (CAD) treated with narrowband ultraviolet B (NB UVB) phototherapy, especially in Asian patients. We aim to evaluate the efficacy and safety of NB UVB phototherapy in Chinese patients with CAD. 19 CAD patients of Fitzpatrick skin phototype IV received NB UVB phototherapy in spring and treatments were given 3 times weekly with incremental dose and maintenance therapy was given twice weekly for 3-4 weeks. The mean initial, endpoint, and cumulative dose of NB UVB was 0...
October 19, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/29046024/clinical-impact-in-the-real-life-of-guidelines-recommendations-for-atopic-dermatitis-in-a-tropical-population-teccema-cohort
#19
Jorge Sánchez, Yuliana Toro, Ricardo Cardona
BACKGROUND: Real-life impact of guidelines for the management of atopic dermatitis has been poorly studied. OBJECTIVE: To assess atopic dermatitis clinical control in residents of a tropical area managed according to international consensuses. METHODS: Prospective study with a 24-month follow-up. Clinical response was assessed with SCORAD, DLQI and a subjective scale (SS) on severity perception by the patient. RESULTS: Two-hundred and thirty-three patients were stratified according to SCORAD: 53 had mild severity (22%), 116 moderate (49%) and 64 severe (27%)...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29041838/psychodermatology-liaison-clinic-in-india-a-working-model
#20
Nupur Goyal, Shrutakirthi Shenoi, Smitha S Prabhu, K Sreejayan, Ravindra Munoli, Shweta Rai
Literature reports suggest that up to 30% of dermatology patients have associated psychiatric co-morbidity. A psychodermatology liaison (PD) clinic is essential to deal with such patients, which is almost non-existent in the Indian scenario. In order to report the working pattern of such a clinic and to determine its efficacy with the help of Dermatology Life Quality Index (DLQI) and Short Assessment of Patient Satisfaction (SAPS) questionnaires, we investigated patients with suspected psychocutaneous diseases in an open-labelled two-year prospective study...
January 1, 2017: Tropical Doctor
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