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https://www.readbyqxmd.com/read/28797188/validation-of-psychometric-properties-and-development-of-response-criteria-for-the-psoriasis-symptoms-and-signs-diary-pssd-results-from-a-phase-iii-clinical-trial
#1
April Armstrong, Luis Puig, Richard Langley, Tsen Fang Tsai, Michael Song, Yasmine Wasfi, Jingzhi Jiang, Shu Li, Chenglong Han
PURPOSE: The Psoriasis Symptoms and Signs Diary (PSSD) is a patient-reported instrument that assesses severity of six psoriasis symptoms (itch, skin tightness, burning, stinging, and pain,) and five signs (dryness, cracking, scaling, shedding/flaking, redness, and bleeding). MATERIALS AND METHODS: PSSD symptoms and signs summary scores (0-100) were derived based on individual item scores (0-10 [absent-worst imaginable]). Using Psoriasis Area and Severity Index [PASI], Investigator's Global Assessment [IGA] and Dermatology Life Quality Index [DLQI]) data from the NAVIGATE trial of patients with moderate-to-severe psoriasis, analyses were conducted to further validate the PSSD (7-day recall version) and establish criteria for clinically meaningful improvements (CMIs)...
August 11, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28797174/the-dermatology-life-quality-index-dlqi-and-the-hospital-anxiety-and-depression-hads-in-chinese-rosacea-patients
#2
Yanyu Wu, Chaowei Fu, Wei Zhang, Caixia Li, Jie Zhang
The study aims to investigate the quality of life (QOL) and the psychological situation in Chinese patients with rosacea. A total of 196 healthy controls and 201 rosacea patients were involved in the final analysis. The general information, the Dermatology Life Quality Index (DLQI) and the Hospital Anxiety and Depression Scale (HADS) were collected. Significantly higher DLQI, anxiety and depression score were observed in the rosacea group compared to the control group (p < .01). Total DLQI score of patients was positively related with anxiety (r = ...
August 10, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28796910/factors-predicting-the-self-evaluated-health-of-hidradenitis-suppurativa-patients-recruited-from-an-outpatient-clinic
#3
R Kjaersgaard Andersen, P Theut Riis, G B E Jemec
OBJECTIVES: In recent years, Hidradenitis suppurativa has received increased attention, but still lack well-defined, robust patient reported outcome measures. Such measures are likely to be influenced by contextual factors. We therefore aim to describe the association of biological and other factors with HS patient's self-evaluated health as reflected by the EQ5D VAS score. METHODS: This cross-sectional study measured basic information, Dermatology Life Quality Index, Major Depression Inventory, and Euro-QoL-5D...
August 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28795763/determinants-of-psychosocial-health-in-psoriatic-patients-a-multi-national-study
#4
Karolina Lesner, Adam Reich, Jacek C Szepietowski, Florence J Dalgard, Uwe Gieler, Lucía Tomas-Aragones, Lars Lien, Françoise Poot, Gregor B Jemec, Laurent Misery, Csanád Szabó, Dennis Linder, Francesca Sampogna, Andrea W M Evers, Jon Anders Halvorsen, Flora Balieva, Andrey Lvov, Servando E Marron, Ilknur K Altunay, Andrew Y Finlay, Sam S Salek, Jörg Kupfer
There are limited data on the differences in the impact of psoriasis between various countries with respect to quality of life (QoL). The aim of this study was to explore the psychosocial health of patients with psoriasis in different European countries. A total of 682 patients were recruited in 13 European countries. All patients completed a questionnaire regarding socio-demographic information, negative life events, suicidal ideation and satisfaction with their dermatologist. Depression and anxiety were assessed with the Hospital Anxiety and Depression Scale (HADS), and QoL with the Dermatology Life Quality Index (DLQI) and EuroQoL (EQ-5D)...
August 10, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28777015/is-weekly-dose-of-adalimumab-a-simple-approach-for-resistant-psoriasis
#5
Sara Mazzilli, Arianna Zangrilli, Mauro Bavetta, Luca Bianchi
Backgroud: In real life, dose escalation can be a good approach for increasing efficacy in a subgroup of patients with an insufficient response to biologic therapy, reducing the signs and symptoms of psoriasis and improving the quality of life (QOL). OBJECTIVE: To determine the effectiveness of escalating adalimumab dosage from 40 mg eow to 40 mg weekly in a patient affected by psoriasis (PsO) and psoriatic arthritis (PsA) with < PASI 50 response following 364 weeks treatment...
August 4, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28771657/time-pasi-and-dlqi-of-psoriasis-patients-who-drop-out-of-clinical-trials-on-etanercept-due-to-lack-of-efficacy-a-pooled-analysis-from-ten-clinical-trials
#6
A Nast, M Dilleen, W Liyanage, L Aikman, P Szczypa, C Dressler
BACKGROUND: Patient-reported outcomes in psoriasis studies are assessed at specific study time points. If a treatment has not become effective by a certain time point, it may increase the likelihood of patients being dissatisfied and leaving a clinical study. OBJECTIVES: Generate evidence concerning the number of patients dropping out of etanercept trials over time including PASI and DLQI data. METHODS: Data from psoriasis patients in ten trials with etanercept were pooled...
August 3, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28762236/conceptualisation-development-and-validation-of-t-qol%C3%A2-teenagers-quality-of-life-a-patient-focused-measure-to-assess-quality-of-life-of-adolescents-with-skin-diseases
#7
M K A Basra, M S Salek, D Fenech, A Y Finlay
AIM: To develop and validate a dermatology-specific quality of life (QoL) instrument for adolescents with skin diseases. METHODS: Qualitative semi-structured interviews were conducted with adolescents with skin disease to gain in-depth understanding of how skin diseases affect their QoL. A prototype instrument based on the themes identified from content analysis of interviews was tested in several stages, using Classical Test Theory (CTT) and Item Response Theory (IRT) models to develop this new tool and conduct its psychometric evaluation...
July 31, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28761839/a-real-world-study-to-assess-the-effectiveness-of-itolizumab-in-patients-with-chronic-plaque-psoriasis
#8
Anchala Parthasaradhi, Vinay Singh, S G Parasramani, Nishi Yadav, D S Krupashankar, Manish Soni, Rakesh Bansal
BACKGROUND: While clinical trial data on the efficacy of itolizumab in the management of psoriasis is relatively well documented, data on the effectiveness of this humanized IgG1 monoclonal antibody in real-world settings is sparse. AIMS: The current study assessed the effectiveness of itolizumab in real-world settings. MATERIALS AND METHODS: This study assessed psoriasis area severity index (PASI), dermatology quality of life index (DLQI), safety, and tolerability data from a registry of itolizumab maintained by Syngene International, Bangalore...
July 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28761295/the-clinical-profile-of-patients-with-psoriasis-in-korea-a-nationwide-cross-sectional-study-epi-psode
#9
Hae Jun Song, Chul Jong Park, Tae Yoon Kim, Yong Beom Choe, Seok-Jong Lee, Nack In Kim, Jae We Cho, Jie Hyun Jeon, Min Soo Jang, Jai Il Youn, Myung Hwa Kim, Joonsoo Park, Ki Ho Kim, Byung Soo Kim, Sang Woong Youn, Joo-Heung Lee, Min-Geol Lee, Sung Ku Ahn, Young Ho Won, Seok Kweon Yun, Bong Seok Shin, Seong Jun Seo, Ji Yeoun Lee, Kwang Joong Kim, Young Suck Ro, Youngdoe Kim, Dae Young Yu, Jee-Ho Choi
BACKGROUND: Psoriasis is an immune-mediated, chronic inflammatory disease affecting multiple aspects of patients' lives. Its epidemiology varies regionally; however, nationwide epidemiologic data on psoriasis depicting profile of Korean patients has not been available to date. OBJECTIVE: To understand nationwide epidemiologic characteristics and clinical features of adult patients with psoriasis visited university hospitals in Korea. METHODS: This multicenter, non-interventional, cross-sectional study recruited 1,278 adult patients with psoriasis across 25 centers in Korea in 2013...
August 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28738881/assessment-of-quality-of-life-in-patients-with-post-kalaazar-dermal-leishmaniasis
#10
Biplab Pal, Krishna Murti, Niyamat Ali Siddiqui, Pradeep Das, Chandra Shekhar Lal, Rajendra Babu, Manoj Kumar Rastogi, Krishna Pandey
BACKGROUND: Post kala-azar dermal leishmaniasis (PKDL) is a dermatological disorder caused by protozoal parasite Leishmania donovani. PKDL cases are thought to be a reservoir of parasites and may increase cases of visceral leishmaniasis. The disease is not life threatening but cosmetic disfigurement associated with it may impair the patients' quality of life. This study aimed to assess the health related quality of life in patients with post kalaazar dermal leishmanasis for the first time...
July 24, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28735828/investigation-of-dietary-supplements-prevalence-as-complementary-therapy-comparison-between-hospitalized-psoriasis-patients-and-non-psoriasis-patients-correlation-with-disease-severity-and-quality-of-life
#11
Hadis Yousefzadeh, Mahmoud Mahmoudi, Mahnaz Banihashemi, Maryam Rastin, Farahzad Jabbari Azad
OBJECTIVES: Psoriasis patients are often displeased with traditional medical treatments and they may self-prescribe dietary supplements as an alternative or complementary treatments. We aimed to investigate the prevalence of self-medication of dietary supplements among psoriasis and non-psoriasis cases and its impact on disease severity and quality of life. DESIGN AND SETTING: This case-control study evaluated 252 records of psoriasis patients and 245 non-psoriasis cases...
August 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28714180/tofacitinib-for-the-treatment-of-moderate-to-severe-chronic-plaque-psoriasis-in-japanese-patients-subgroup-analyses-from-a-randomized-placebo-controlled-phase-3-trial
#12
Masatoshi Abe, Chikako Nishigori, Hideshi Torii, Hironobu Ihn, Kei Ito, Makoto Nagaoka, Naoki Isogawa, Isao Kawaguchi, Yukiko Tomochika, Mihoko Kobayashi, Anna M Tallman, Kim A Papp
Tofacitinib is an oral Janus kinase inhibitor. These post-hoc analyses assessed tofacitinib efficacy and safety in Japanese patients with psoriasis enrolled in a 52-week global phase 3 study. Patients received tofacitinib 5 mg, tofacitinib 10 mg or placebo twice daily (b.i.d.); placebo-treated patients advanced to tofacitinib at week 16. Primary efficacy end-points were the proportions of patients with 75% or more reduction from baseline Psoriasis Area and Severity Index (PASI-75) and Physician's Global Assessment (PGA) of "clear" or "almost clear" (PGA response) at week 16...
July 17, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28709817/evaluation-of-a-guidelines-based-approach-to-the-treatment-of-chronic-spontaneous-urticaria
#13
Jorge Sánchez, Josefina Zakzuk, Ricardo Cardona
BACKGROUND: International scientific associations have made recommendations for the management of chronic spontaneous urticaria (CSU) that have been summarized in clinical guidelines. OBJECTIVE: To evaluate the clinical impact of guideline recommendations for CSU management. METHODS: A multicenter, triple-blinded, prospective, randomized study (the Urticaria Research of Tropical Impact and Control Assessment project; ClinicalTrials.gov identifier: NCT01940393) was performed...
July 11, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28702987/quality-of-life-and-psychological-disturbances-in-adults-with-atopic-dermatitis-in-the-czech-republic
#14
E Březinová, M Nečas, V Vašků
Atopic dermatitis (AD) leads to severe psychosocial disturbances that are quite frequently underestimated. We evaluate the quality of life (QoL) of adult patients with AD and their family members using DLQI, B-IPQ, FDLQI questionnaires, observe psychopathological features with CAQ II questionnaire and evaluate correlations between QoL, psychological disturbances and objective/subjective parameters of disease severity. A reduction in QoL has been proven by all questionnaires with statistically significant relationships between all of them...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28686974/phytotherapeutic-potential-of-natural-herbal-medicines-for-the-treatment-of-mild-to-severe-atopic-dermatitis-a-review-of-human-clinical-studies
#15
REVIEW
Zahid Hussain, Hnin Ei Thu, Ahmad Nazrun Shuid, Prashant Kesharwani, Shahzeb Khan, Fahad Hussain
For many decades, natural herbal medicines, polyherbal formulations and/or decoctions of plant-derived materials have widely been accepted as alternative complementary therapies for the treatment, cure or prevention of a wide range of acute and chronic skin diseases including chronic herpes, prurigo, acute and chronic wounds, psoriasis and atopic dermatitis (AD). This review was aimed to summarize and critically discuss about the therapeutic viability and clinical applicability of natural herbal medicines for the treatment of AD in human...
September 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28676885/rasch-analysis-of-the-dermatology-life-quality-index-reveals-limited-application-to-chinese-patients-with-skin-disease
#16
Zehui He, Riccardo Lo Martire, Chuanjian Lu, Hongxia Liu, Lin Ma, Ying Huang, Yongmei Li, Liyun Sun, Yanping Bai, Wali Liu, Xushan Zha
The objective of this study was to examine the psychometric properties of the Chinese version of the Dermatology Life Quality Index (DLQI) and to assess the invariance of its items with respect to several patient parameters via Rasch analysis. Data were aggregated from 9,845 patients with various skin diseases across 9 hospitals in different regions of China. The response structure, local independence, and reliability of the DLQI scale were analysed in a partial credit model, and differential item functioning (DIF) across region, disease, gender, and age were assessed with a Mantel-Haenszel procedure...
July 5, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28676884/suicidal-ideation-in-adult-patients-with-atopic-dermatitis-a-german-cross-sectional-study
#17
Jan Dieris-Hirche, Uwe Gieler, Frank Petrak, Wolfgang Milch, Bert Te Wildt, Barbara Dieris, Stephan Herpertz
A cross-sectional study was performed to assess symptoms of suicidality, depression and anxiety in adult patients with atopic dermatitis. The study describes the relationships between these psychiatric symptoms and skin-specific factors, such as atopic dermatitis severity and skin satisfaction. A sample of 181 German patients with atopic dermatitis was compared with a control group of 64 persons with healthy skin with a similar age and gender distribution. Standardized questionnaires were used to assess suicidality (Pöldinger's Scale), depression and anxiety (Hospital Anxiety and Depression Scale; HADS), quality of life (Dermatology Life Quality Index; DLQI), atopic dermatitis severity (Patient-Oriented Scoring Atopic Dermatitis; PO-SCORAD) and skin satisfaction (Skin Satisfaction Questionnaire; SSQ)...
July 5, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28670943/high-rates-of-secondary-non-adherence-causes-decreased-efficacy-of-0-1-topical-tacrolimus-in-adult-eczema-patients-results-from-a-multicenter-clinical-trial
#18
Min-Young Yang, Hyunju Jin, Woo-Haing Shim, Gun-Wook Kim, Hoon-Soo Kim, Hyun-Chang Ko, Hyo-Jin Kim, Ho-Seok Suh, Sook-Kyung Lee, So-Young Jung, Hye-Sook Kim, Kyung-Min Lim, Moon-Bum Kim, Byung-Soo Kim
BACKGROUND: Patients tend to apply topical medications less frequently, in improper amounts. Not only frequency but also application amount may influence treatment outcome. However, studies on relationship between application amount and objective treatment outcome have rarely been conducted. OBJECTIVE: To assess efficacy of topical agent according to application amount in adult patients, using the finger-tip unit method. METHODS: The efficacy of 0...
July 18, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28665162/the-effect-of-pulsed-dye-laser-on-cutaneous-leishmaniasis-and-its-impact-on-the-dermatology-life-quality-index
#19
Mohamed L Elsaie, Shady M Ibrahim
BACKGROUND AND OBJECTIVE: Cutaneous leishmaniasis is a skin condition of prevalence especially in the Middle Eastern region. The Pulsed dye laser (PDL) has not been thoroughly evaluated for treatment of cutaneous leishmaniasis (CL). We assessed primarily the efficacy of 595nm PDL in the treatment of CL lesions and interpreted its impact on the quality of life of affected patients as measured by the Dermatology Life Quality Index (DLQI). PATIENTS AND METHODS: 25 lesions from 12 patients were treated with a single pass of PDL over the whole lesions to develop a purpuric end point...
June 30, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28654131/topical-oxybutynin-10-gel-for-the-treatment-of-primary-focal-hyperhidrosis-a-randomized-double-blind-placebo-controlled-split-area-study
#20
Ofir Artzi, Christophoros Loizides, Eyal Zur, Eli Sprecher
Limited efficacy, costs, side-effects and complications are issues of concern for most current therapeutic modalities for focal hyperhidrosis. This study evaluated the efficacy of topical oxybutynin 10% gel in treating 61 patients with primary focal hyperhidrosis. The gel was applied to the right or left axilla, and palm or sole and a placebo compound to the contralateral side for 30 days. A blinded visual grading of the change in starch-iodine tests was performed by 2 non-involved physicians. The Hyperhidrosis Disease Severity Scale (HDSS) and Dermatology Life Quality Index (DLQI) questionnaires were administered before and after treatment...
June 27, 2017: Acta Dermato-venereologica
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