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Joanna Bartosińska, Joanna Purkot, Małgorzata Kowal, Anna Michalak-Stoma, Dorota Krasowska, Grażyna Chodorowska, Krzysztof Giannopoulos
BACKGROUND: Psoriasis is a chronic autoinflammatory disease whose underlying molecular mechanisms remain unclear. The disease is mediated by the cells and molecules of both the innate and adaptive immune systems. Some T cell surface molecules, including neuropilin-1 (NRP1), programmed death 1 (PD-1) and the human leukocyte antigen G (HLA-G), are known to play a role in the maintenance of immune tolerance. OBJECTIVES: The aim of this study was to investigate HLA-G, NRP1 and programmed cell death gene (PDCD1) mRNA expression in psoriatic patients...
April 24, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Emanuele Cozzani, Dennis Linder, Martina Burlando, Fabio Gallo, Francesca Sampogna, Marco Bruzzone, Carlotta Tacchino, Francesco Drago, Aurora Parodi
BACKGROUND: PSOdisk is a 10-item visual instrument, aimed at assessing the burden of disease in patients with psoriasis. OBJECTIVES: To compare PSOdisk with a scientifically validated questionnaire, the Dermatology Life Quality Index (DLQI), and asses both tools in relation to Psoriasis Severity Index (PASI) and patient acceptance. MATERIALS & METHODS: Fifty patients with cutaneous (PSO) and/or arthritic psoriasis (PSA) were recruited...
May 23, 2018: European Journal of Dermatology: EJD
Suman Bagchi, Chaturbhuja Nayak, Lex Rutten, Munmun Koley, Subhranil Saha, Mousumi Roy, Sk Jahir Abbas, Simantini Ghosh, Suman Halder, Ghulam Nabi Wani, Anaitulah Ahmad Mir, Showket Ahmad Bhat
BACKGROUND:  Contact dermatitis (CD) is a frequently occurring medical condition, for which Vinca minor (VM) is one of the recommended homeopathic medicines. However, the symptoms indicating this medicine have not yet been assessed systematically. Likelihood ratio (LR), based on Bayesian statistics, may yield better estimation of a medicine's indication than the existing method of entry of symptoms into materia medica and repertories. METHODS:  We investigated LRs of four CD symptoms of VM: (1) great sensitiveness of skin, with redness and soreness from slightest rubbing; (2) weeping eczema with foul, thick crusts; (3) itching amelioration in open air; and (4) CD of scalp...
May 21, 2018: Homeopathy: the Journal of the Faculty of Homeopathy
Adrienn Katalin Poór, Miklós Sárdy, Tamás Cserni, Valentin Brodszky, Péter Holló, László Gulácsi, Éva Remenyik, Andrea Szegedi, Fanni Rencz, Márta Péntek
INTRODUCTION: The health status and health-related quality of life (HRQoL) of patients with psoriasis in Hungary are understudied. AIM: To assess HRQoL in psoriasis patients, to compare HRQoL of psoriasis patients to that of the general public in Hungary and to identify predictors of HRQoL. METHOD: Between 2012 and 2016, two cross-sectional surveys were carried out among psoriasis patients at two academic dermatology departments. HRQoL was assessed by EQ-5D-3L, EQ Visual Analogue Scale (EQ VAS) and Dermatology Life Quality Index (DLQI)...
May 2018: Orvosi Hetilap
Wei Xu, Yan Li, Zeyu Chen, Teng Liu, Shan Wang, Linfeng Li
BACKGROUND: Currently there is no cure for severe atopic dermatitis (AD). Wet-wrap therapy (WWT) has also been used to treat pediatric AD and shown a satisfactory effectiveness, but clinical evidence supporting the use of WWT on severe adult AD is still insufficient. METHODS: Twelve patients (8 men and 4 women) with severe AD (SCORing Atopic Dermatitis [SCORAD] score≥50) treated between January 2015 and September 2017 in our hospital were included. The patients underwent WWT (daily dose: 15g halometasone cream+100g Vaseline ointment) twice daily for 2 hours/session for 7 days...
May 16, 2018: Postgraduate Medicine
S Steinke, F C Beikert, A Langenbruch, R Fölster-Holst, J Ring, J Schmitt, T Werfel, S Hintzen, N Franzke, M Augustin
BACKGROUND: Quality indicators are essential tools for the assessment of health care, in particular for guideline-based procedures. OBJECTIVE: 1) Development of a set of indicators for the evaluation of process and outcomes quality in atopic dermatitis (AD) care. 2) Application of the indicators to a cross-sectional study and creation of a global process quality index. METHODS: An expert committee consisting of 10 members of the German guideline group on atopic dermatitis condensed potential quality indicators to a final set of 5 outcomes quality and 12 process quality indicators using a Delphi panel...
May 15, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
E Q Wang, M Radjenovic, M A Castrillón, G Feng, D F Murrell
BACKGROUND: Autoimmune blistering diseases (AIBD) is known to negatively impact upon quality of life (QoL), however there is a paucity of research on the effect of AIBD on work productivity. AIBD can be quite disfiguring in terms of a patient's appearance due to its blistering nature. OBJECTIVE: To determine the impact of AIBD on work productivity and to determine whether patients are stigmatized at work due to their appearance. METHODS: Sixty one patients with AIBD completed the Work Productivity and Activity Impairment Questionnaire-Specific Health Problem (WPAIQ-SHP), the Dermatology Life Quality Index (DLQI), the Autoimmune Bullous Disease Quality of Life (ABQOL), and the Treatment of Autoimmune Bullous Disease Quality of Life questionnaires (TABQOL)...
May 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
J Pölking, C Zeidler, F Schedel, N Osada, M Augustin, D Metze, M P Pereira, G Yosipovitch, J D Bernhard, S Ständer
BACKGROUND: Currently available tools to monitor patients with chronic prurigo over time focus on pruritus and quality of life parameters, while no instrument objectively assessing the pruriginous lesions is yet available. OBJECTIVE: The objective of this study was to develop a physician-assessed Prurigo Activity Score (PAS), a new tool to monitor the distribution and activity of chronic prurigo lesions and to evaluate its reliability and validity. METHODS: The 7-item PAS questionnaire as well as validated pruritus intensity scales (VAS, NRS) and a skin related quality of life score (DLQI) were completed for 264 patients (172 females, age 61 years) at least twice over a period of two years...
May 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
P V Chernyshov, L Tomas-Aragones, L Manolache, A Svensson, S E Marron, A W M Evers, V Bettoli, G B Jemec, J C Szepietowski
According to results of a recent literature search performed by the European Academy of Dermatology and Venereology (EADV) Task Forces (TF) on Quality of Life and Patient Oriented Outcomes (QoL and PO) and Acne, Rosacea and Hidradenitis Suppurativa (ARHS) most of publications where health-related (HR) QoL of acne patients was studied were clinical trials. Members of the EADV TF on QoL and PO decided to detect which acne treatment has the best influence on HRQoL of acne patients. A new literature search was organized to find publications on acne treatment where the HRQoL of patients was assessed as an outcome measure...
May 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Jessica A Walsh, Terri Arledge, Tommi Nurminen, Luke Peterson, Jeffrey Stark
OBJECTIVE: The product of physician's global assessment and body surface area (PGA×BSA) to assess psoriasis severity has previously been investigated in patients with psoriasis, with the aim of assessing PGA×BSA as an alternative to the time-consuming Psoriasis Area and Severity Index (PASI). Here, we investigate PGA×BSA as an alternative to PASI in patients with psoriatic arthritis (PsA). METHODS: Analyses used data from the double-blind, placebo-controlled, RAPID-PsA trial (NCT01087788) that investigated the efficacy of certolizumab pegol (CZP) in patients with PsA...
May 1, 2018: Journal of Rheumatology
Carolina Rocha Barone, Juliana Catucci Boza, Priscilla Granja Machado, Tania Ferreira Cestari
INTRODUCTION: Periorbital hyperchromia (POH) is a multifactorial condition, precipitated or aggravated by sleep disorders, which negatively affects quality of life (QoL). The aim of this study was to evaluate the impact of POH on QoL, sleep quality, and dissatisfaction of affected patients. METHODS: In this cross-sectional study of male and female patients over 18 years, participants were examined, their demographic data were registered, and Dermatology Quality of Life Index (DLQI), Pittsburgh Sleep Quality Index (PSQI-BR), and Visual Analogue Scale (VAS) were used to assess dissatisfaction...
April 30, 2018: Journal of Cosmetic Dermatology
Tomaz Lunder, Pij Marko, Natasa Koser Kolar, Boris Kralj, Nada Kecelj Leskovec
The study was designed as observational retrospective analysis of the data from Slovenian Registry of patients with moderate and severe psoriasis treated with adalimumab, etanercept, infliximab or ustekinumab from 2005 to 2015. The survival rates of biologics were compared using survival analysis, and predictors of discontinuation were evaluated using a Cox regression model. All biologics have been prescribed as a first line therapy for moderate or severe psoriasis; 650 (94.9%) adalimumab, 254 (72.0%) ustekinumab, 76 (69...
April 26, 2018: Biologicals: Journal of the International Association of Biological Standardization
Robabeh Abedini, Maryam Nasimi, Pedram Noormohammad Pour, Atie Moghtadaie, Hamid Reza Tohidinik
Non-melanoma skin cancer (NMSC) is the most prevalent type of cancer among Caucasian populations worldwide. The purpose of this work was to measure quality of life (QOL) of the patients with diagnosis of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) who were referred to our cancer clinic. During 1 year, 95 patients were selected and asked to complete Dermatology Life Quality Index (DLQI) questionnaires. Ninety-five patients with NMSC (74 men and 21 women) with mean age of 64.6 ± 12.5 participated in this cross-sectional study...
April 28, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
P Jensen, C Zachariae, L Skov, R Zachariae
BACKGROUND: Sleep is essential for daytime functioning and health. Given the physical symptoms of psoriasis, a higher prevalence of sleep disorders could be expected. So far, the studies examining sleep disturbance in psoriasis have been of less-than-optimal methodological quality and with mixed results. OBJECTIVES: We aimed to: 1) examine the prevalence of sleep disturbance in patients with plaque psoriasis compared to controls, 2) evaluate associations with health-related quality of life (HRQoL), and 3) examine possible disease-related predictors of disturbed sleep...
April 28, 2018: British Journal of Dermatology
Ricardo Romiti, Lincoln Helder Zambaldi Fabrício, Cacilda da Silva Souza, Leticia Oba Galvão, Caio Cesar Silva de Castro, Aripuanã Cobério Terena, Francisca Regina Oliveira Carneiro, Luiza Keiko Matsuka Oyafuso, Sueli Carneiro, Bernardo Gontijo, Clarice Marie Kobata, Maria de Fátima Paim de Oliveira, Tania Cestari, João Roberto Antônio, Gladys Aires Martins, Silvio Alencar Marques, Sulamita Costa Wirth Chaibub, Ana Carolina Arruda, Paulo Antonio Oldani Félix, Renata Ferreira Magalhães, Luna Azulay Abulafia, Karine A Ferreira, Juliano Souza
PURPOSE: Data on chronic plaque psoriasis severity and its potential clinical and lifestyle implications in the Brazilian population are limited. The primary aim of this study was to assess the clinical severity of plaque psoriasis in Brazil. Further objectives included evaluating potential associations between disease severity and demographic, lifestyle, and clinical characteristics, health-related quality of life (HRQOL), and work productivity. MATERIALS AND METHODS: This observational (noninterventional) cross-sectional study was conducted in 26 dermatologic clinics across 11 Brazilian states...
April 26, 2018: Journal of Dermatological Treatment
Farhan Rasool, Saniya Akhtar, Iffat Hassan, Sumaya Zeerak, Syed Mubashir, Gousia Sheikh
Background: Scalp psoriasis and psoriasis limited to palms and/or soles have been referred to as difficult to control psoriasis. Contact allergy has long been suspected to aggravate existing lesions and cause resistance to therapy in these psoriasis variants. Objectives: The objective of the study was to assess common contact allergens in patients with palmoplantar and scalp psoriasis and the impact of their avoidance on dermatology life quality index (DLQI). Materials and Methods: A total of 54 patients with palmoplantar and scalp psoriasis were patch tested with Indian Standard Series...
March 2018: Indian Journal of Dermatology
Sanjeev B Gupta, Aayush Gupta, Bhavika Shah, Preeti Kothari, Sweety Darall, Dhara Boghara, Sukhnandan Sonkar, Kirti Deo
BACKGROUND: Healthcare workers have a high risk of developing hand eczema. OBJECTIVES: To determine the prevalence and severity of dermatologist-determined hand eczema among healthcare workers, carry out patch testing, and correlate the findings with impairment in quality of life (QoL) and demographic and vocational factors. METHODS: Seven hundred and ten healthcare workers (279 nurses, 246 cleaners, and 185 nursing auxiliaries) were screened for the presence of hand eczema...
April 25, 2018: Contact Dermatitis
Zhenli Kwan, Yii Bonn Bong, Leng Leng Tan, Shu Xian Lim, Adrian Sze Wai Yong, Chin Chwen Ch'ng, Maw Pin Tan, Rokiah Ismail
We investigated whether disease severity and clinical manifestations were associated with depression, anxiety, stress and quality of life in adults with psoriasis. Participants were recruited from a dermatology outpatient clinic at a teaching hospital. Information on sociodemographic characteristics, disease severity, presence of arthropathy and head involvement was specifically recorded. Disease severity was assessed using the Psoriasis Area and Severity Index (PASI). Quality of life and psychological symptoms were measured using the Dermatology Life Quality Index (DLQI) and the Depression Anxiety Stress Scale (DASS), respectively...
April 23, 2018: Archives of Dermatological Research
Simon Francis Thomsen
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with profound negative impact on quality of life. Adalimumab (anti-TNF) is indicated for moderate-to-severe HS unresponsive to conventional therapy. Herein, studies of the change in Dermatology Life Quality Index (DLQI) among patients with HS treated with adalimumab are reviewed. The anticipated gain in DLQI is only modest in patients with HS treated with adalimumab, even in trials of high quality, and does not exceed the established minimal clinically important difference...
April 19, 2018: Journal of Dermatological Treatment
Larissa S Meier, Maria Schubert, Yasemin Göksu, Solveig Esmann, Gabrielle R Vinding, Gregor B E Jemec, Günther F L Hofbauer
BACKGROUND: Actinic keratosis (AK) is a sun-induced skin lesion that may progress to invasive squamous cell carcinoma of the skin. Recently, the Actinic Keratosis Quality of Life questionnaire (AKQoL) was designed for patients with AK in Denmark as a specific quality of life instrument for AK patients. OBJECTIVE: The objective of this study was to adapt the AKQoL for the German language region of Switzerland and to evaluate its psychometric properties (validity, reliability)...
April 18, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
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