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https://www.readbyqxmd.com/read/29315464/baseline-patients-characteristics-as-predictors-for-therapeutic-survival-and-response-in-patients-with-psoriasis-on-biological-treatments
#1
Kenneth K Xie, Anna Braue, Raymond Martyres, George Varigos
BACKGROUND/OBJECTIVES: Biological agents provide a relatively safe and promising long-term therapeutic option for patients with moderate to severe psoriasis in whom conventional treatment has failed. However, these agents are not effective in all patients. We aimed to examine the association of baseline patients' characteristics with the short-term efficacy and the long-term survival of biological therapies in patients with moderate to severe psoriasis. METHODS: We performed a retrospective observational study of all patients who received biological treatment for psoriasis at the Royal Melbourne Hospital (N = 146)...
January 8, 2018: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/29309411/tungiasis-related-life-quality-impairment-in-children-living-in-rural-kenya
#2
Susanne Wiese, Lynne Elson, Hermann Feldmeier
BACKGROUND: Tungiasis (sand flea disease) is a neglected tropical skin disease caused by female sand fleas (Tunga spp.) embedded in the skin of the host. The disease is common in sub-Saharan Africa and predominantly affects children living in impoverished rural communities. In these settings tungiasis is associated with important morbidity. Whether tungiasis impairs life quality has never been studied. METHODS: The study was performed in 50 children with tungiasis, living in resource-poor communities in coastal Kenya...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29304933/comparison-of-adalimumab-and-etanercept-for-the-treatment-of-moderate-to-severe-psoriasis-an-indirect-comparison-using-individual-patient-data-from-randomized-trials
#3
Kim A Papp, Min Yang, Murali Sundaram, John Jarvis, Keith A Betts, Yanjun Bao, James E Signorovitch
OBJECTIVES: To compare outcomes between adalimumab and etanercept in the treatment of moderate to severe plaque psoriasis. METHODS: Study groups included patients randomized to adalimumab or placebo (REVEAL and CHAMPION trials) and those randomized to etanercept or placebo (M10-114 and M10-315 trials). Week 12 outcomes were compared between patients receiving adalimumab and those receiving etanercept after adjusting for cross-trial differences in patient characteristics using propensity score weighting and after subtracting effects of placebo...
January 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29285233/aio-lq-0110-a-randomized-phase-ii-trial-comparing-oral-doxycycline-versus-local-administration-of-erythromycin-as-preemptive-treatment-strategies-of-panitumumab-mediated-skin-toxicity-in-patients-with-metastatic-colorectal-cancer
#4
Melanie Kripp, Nicole Prasnikar, Ursula Vehling-Kaiser, Julia Quidde, Salah-Eddin Al-Batran, Alexander Stein, Kai Neben, Carla Verena Hannig, Hans Werner Tessen, Tanja Trarbach, Axel Hinke, Ralf-Dieter Hofheinz
Background: Dermatologic toxicities, especially akne-like skin rash, are the most common side-effects associated with anti-epidermal growth factor receptor (EGFR) therapy. Preemptive treatment with oral tetracyclines is recommended as a standard. Topical prophylactic options have thus far not been compared to tetracyclines. In the current study, we sought to establish an alternative topical treatment. Patients and methods: In this multicentre, randomized, open-label phase II study patients with (K)Ras-wildtype colorectal cancer receiving panitumumab were randomized (1:1) to receive either doxycycline 100 mg b...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29258952/5-aminolevulinic-acid-photodynamic-therapy-in-refractory-vulvar-lichen-sclerosus-et-atrophicus-series-of-ten-cases
#5
Ting Lan, Yongzhen Zou, Michael R Hamblin, Rui Yin
BACKGROUND: Vulvar lichen sclerosus et atrophicus (VLSA) is a chronic inflammatory skin disease of unknown etiology that mainly affects postmenopausal and perimenopausal women. The primary clinical symptoms of VLSA are itching, burning pain, and dyspareunia that can results in decreased quality of life. Existing therapies including topical corticosteroid ointment, topical calcineurin inhibitors, estrogens, are not very effective for treatment of VLSA. OBJECTIVE: To evaluate the effectiveness and safety of 5-aminolevulinic acid mediated photodynamic therapy (ALA-PDT) in the treatment of VLSA...
December 16, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29241681/validation-of-scratching-severity-as-an-objective-assessment-for-itch
#6
Jeremy Udkoff, Jonathan I Silverberg
There are currently no simple, standardized, objective assessments of itch for clinical trials and practice. We sought to validate and test the severity of scratching as an objective measure of itch (4-point ordinal scale ranging from 0 [not present] to 3 [very prominent] based on the observation of scratching lesions). We performed a prospective outpatient study using questionnaires and evaluations by a dermatologist in adults with atopic dermatitis (AD) (n=261). Severity of scratching best correlated with patient-reported global AD severity (Kendal's Tau=0...
December 11, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29237254/the-impact-of-skin-problems-on-the-quality-of-life-in-patients-treated-with-anticancer-agents-a-cross-sectional-study
#7
Jaewon Lee, Jin Lim, Jong Seo Park, Miso Kim, Tae-Yong Kim, Tae Min Kim, Kyung-Hun Lee, Bhumsuk Keam, Sae-Won Han, Je-Ho Mun, Kwang Hyun Cho, Seong Jin Jo
Purpose: Patients treated with anticancer agents often experience a variety of treatment-related skin problems, which can impair their quality of life. Materials and Methods: In this cross-sectional study, Dermatology Life Quality Index (DLQI) and clinical information were evaluated in patients under active anticancer treatment using a questionnaire survey and their medical records review. Result: Of 375 evaluated subjects with anticancer therapy, 136 (36...
December 14, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29235664/an-observer-blinded-randomised-controlled-pilot-trial-comparing-localised-immersion-psoralen-ultraviolet-a-puva-with-localised-narrowband-ultraviolet-b-nbuvb-for-the-treatment-of-palmar-hand-eczema
#8
D Brass, T Fouweather, D D Stocken, C Macdonald, J Wilkinson, J Lloyd, P M Farr, N J Reynolds, P J Hampton
BACKGROUND: Hand eczema is a common inflammatory dermatosis that causes significant patient morbidity. Symptoms such as pain, itch and localised swelling contribute to disruption of activities of daily living, lack of sleep, and missed days from work. The aetiology is often multifactorial. Previous studies comparing psoralen ultraviolet A (PUVA) and narrowband ultraviolet B (NBUVB) have been small, non-randomised and retrospective. OBJECTIVES: To conduct an observer blinded randomized controlled pilot study using validated scoring criteria to compare immersion PUVA with NBUVB for the treatment of chronic hand eczema unresponsive to topical steroids...
December 13, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29231502/-clinical-observation-of-chronic-perianal-eczema-treated-with-auricular-point-sticking-therapy-and-western-medication
#9
Yong Wen, Jun Li, Qing Long, Chuan Wan, Xiaolin Lan, Ye Chen
OBJECTIVE: To observe the differences in the therapeutic effects on chronic perianal eczema between auricular point sticking therapy and auricular sticking pseudo-press therapy on the basis of the treatment with western medication. METHODS: Ninety patients were randomized into an auricular therapy group and an auricular pseudo-press therapy group (pseudo group), 45 cases in each one. The western medication was used in both of the groups. In the auricular therapy group, the auricular sticking method with semen vaccariae was added at Fengxi (SF1,zi), Shenshangxian (TG2p), Duipingjian (AT1,2,4i), Fei (CO14), Pi (CO13), Gangmen (HX5)...
June 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231053/the-contribution-of-malodour-in-quality-of-life-of-patients-with-hidradenitis-suppurativa
#10
Afsaneh Alavi, Delaram Farzanfar, Rosa Kyuwon Lee, Dalal Almutairi
BACKGROUND: Malodourous discharge in patients with hidradenitis suppurativa (HS) has a strong psychosocial impact and is often reported as a source of embarrassment, low self-esteem, social stigma, and barriers to interpersonal relationships. Malodour is a maker of bacterial colonization, and its role in HS is understudied. OBJECTIVES: The aim of this study is to assess the relationship between severity of malodourous discharge and quality-of-life impairment in patients with HS...
December 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29227263/-adaptive-regulatory-mechanisms-of-alopecia-areata
#11
L Bolotnaja, I Serbina
Failure of adaptive mechanisms leads to structural and functional damage at all levels and of neuroendocrinal and immune systems, which are pathogenetic basis of development of autoimmune diseases, in particular. The objective of this work was to assess the condition of adaptive hormones, such as cortisol and insulin, coefficient of stress of adaptive potential "K" and also dermatologic life quality index (DLQI) of the diseased with alopecia areata (AA). 48 patients with different forms of AA aged between 18 and 52 were examined...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29221588/eau-thermale-d%C3%A2-av%C3%A3-ne-et-dermatite-atopique-av%C3%A3-ne%C3%A2-s-thermal-water-and-atopic-dermatitis
#12
D Guerrero, E Garrigue
Atopic dermatitis (AD) is the most frequent disease treated at the Avène hydrotherapy center. Children represent a large part of the population due to the high prevalence of AD in early childhood. Avène thermal spring water (ATSW) has been known for its therapeutic effects since the middle of the 18th century. It has been greatly studied over the last decades, with a comprehensive fundamental, pharmaco-clinical and clinical approach. Cohort studies using the Scoring Atopic Dermatitis (SCORAD) clinical score and the Dermatology Life Quality Index (DLQI) or the Children's Dermatology Life Quality Index [CDLQI]) quality of life scores, allowed to confirm the clinical results obtained from the previous studies...
January 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29220542/safety-and-efficacy-of-apremilast-through-104-weeks-in-patients-with-moderate-to-severe-psoriasis-who-continued-on-apremilast-or-switched-from-etanercept-treatment-findings-from-the-liberate-study
#13
K Reich, M Gooderham, A Bewley, L Green, J Soung, R Petric, J Marcsisin, J Cirulli, R Chen, V Piguet
BACKGROUND: Apremilast, an oral phosphodiesterase 4 inhibitor, has demonstrated efficacy in patients with moderate to severe psoriasis. OBJECTIVE: To evaluate long-term efficacy and safety of apremilast in biologic-naive patients with moderate to severe plaque psoriasis and safety of switching from etanercept to apremilast in the phase 3b LIBERATE trial. METHODS: Two hundred fifty patients were randomized to placebo, apremilast 30 mg BID, or etanercept 50 mg QW through Week 16; thereafter, all patients continued or switched to apremilast through Week 104 (extension phase)...
December 8, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29204388/clinic-based-group-multi-professional-education-causes-significant-decline-in-psoriasis-severity-a-randomized-open-label-pilot-study
#14
Shubh Mohan Singh, Tarun Narang, Keshavamurthy Vinay, Aditi Sharma, Ashirbad Satapathy, Sanjeev Handa, Sunil Dogra
Background: The evidence for efficacy of psychoeducational interventions in psoriasis is not well researched. Objective: The objective of this study was to assess the benefits of a group, multi-professional, psychoeducational training in psoriasis. Materials and Methods: Adults with moderate-to-severe psoriasis were randomized into psychoeducational intervention plus treatment (intervention arm [IA]) and treatment as usual alone (control arm [CA]) groups using random number tables...
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29186268/quality-of-life-in-men-diagnosed-with-anogenital-warts
#15
Caio Cavassan de Camargo, Maria Paula Barbieri D'Elia, Helio Amante Miot
Anogenital warts are a worldwide public health problem. They consist of epithelial proliferations caused by HPV, whose transmission occurs mainly through sexual intercourse. In this study, we evaluated their impact on the quality of life of adult males. We interviewed 88 men in an outpatient clinic for sexually transmitted diseases at a Brazilian public institution, using the DLQI-BRA questionnaire. Most patients (81%) presented mild or no impairment of quality of life. The main dimensions affected were sex life, symptoms, and embarrassment...
May 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29177148/descriptive-epidemiology-of-hidradenitis-suppurativa-in-greece-a-study-of-152-cases
#16
Alexandros C Katoulis, Aikaterini I Liakou, Nikolaos Rotsiamis, Stefanos Bonovas, Evangelia Bozi, Efstathios Rallis, Christos Christodoulou, Dimitrios Rigopoulos
Background/Objective: Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease that remarkably affects the patients' quality of life. A prospective study of 152 HS patients was conducted in order to depict the clinico-epidemiological characteristics of HS patients in Greece. Materials and Methods: From February 2015 to August 2016, 152 patients attended the Hidradenitis Suppurativa Outpatient Clinic of our department. The most important clinico-epidemiological data of the patients were registered...
October 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29171925/clinical-and-photobiological-response-in-eight-patients-with-solar-urticaria-under-treatment-with-omalizumab-and-review-of-the-literature
#17
D Morgado-Carrasco, X Fustà-Novell, S Podlipnik, A Combalia, P Aguilera
BACKGROUND: Solar urticaria (SU) is a rare photodermatosis. Treatment is challenging and outcomes are often disappointing. Omalizumab is an anti-IgE, currently approved for treatment of chronic spontaneous urticaria. We sought to evaluate therapy with omalizumab in refractory SU and describe predictive factors for response. MATERIALS/METHODS: Patients with refractory SU under treatment with omalizumab were included in this study. Clinical outcome was evaluated using the Urticaria Activity score 7 (UAS7), Dermatology Life Quality Index (DLQI) and Pruritus Visual Analogue scale (VAS)...
November 24, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29171861/matching-adjusted-indirect-comparison-of-efficacy-in-patients-with-moderate-to-severe-plaque-psoriasis-treated-with-ixekizumab-versus-secukinumab
#18
R B Warren, A Brnabic, Daniel Saure, R G Langley, K See, J J Wu, A Schacht, L Mallbris, A Nast
BACKGROUND: Head-to-head randomised studies comparing ixekizumab and secukinumab in the treatment of psoriasis are not available. OBJECTIVE: Assess efficacy and quality of life with ixekizumab vs. secukinumab treatment using matching-adjusted indirect comparisons. METHODS: Psoriasis Area and Severity Index (PASI) improvement of at least 75%, 90% and 100% and Dermatology Life Quality Index (DLQI) 0/1 response rates for approved doses of ixekizumab (160 mg at Week 0, then 80 mg every two weeks for the first 12 weeks) and secukinumab (300 mg at Weeks 0, 1, 2, 3 and 4, then 300 mg every 4 weeks) treatment were compared using data from active (etanercept and ustekinumab) and placebo-controlled studies...
November 24, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29171393/characterization-of-skin-th17-transcriptional-profiles-in-psoriatic-patients-under-adalimumab-biotherapy
#19
Amandine Buffiere-Morgado, Elodie Couderc, Adriana Delwail, Laure Favot, Jean-François Jegou, Elisabeth Solau, Gérard Guillet, Jean-Claude Lecron, Frank Morel
In psoriasis, a specific cytokine network has been described to play a central role in the pathophysiology of the disease. Anti-cytokine therapeutic approaches have been largely developed and TNFα constitutes the main target. Adalimumab is a human anti-TNFα monoclonal antibody that has been reported to demonstrate clinical efficacy and safety, resulting in reversal of epidermal hyperplasia and cutaneous inflammation. We aimed to analyse changes in the skin inflammatory transcriptomic profile in psoriatic patients during adalimumab therapy...
November 24, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29147651/prevalence-and-relevance-of-pruritus-in-pregnancy
#20
Justyna Szczęch, Artur Wiatrowski, Lidia Hirnle, Adam Reich
Pregnant women are at greater risk to suffer from chronic pruritus, but data on this symptom in this group is very limited. The aim of this study was to investigate the prevalence, clinical characteristics, and the importance of pruritus in pregnant women. A total of 292 consecutive pregnant women at the 33.0 ± 6.1 weeks of gestation (WoG) were recruited into this prospective, cross-sectional study. All patients underwent thorough anamnesis and detailed physical examination with the special emphasis on pruritus...
2017: BioMed Research International
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