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https://www.readbyqxmd.com/read/29913516/medication-for-opioid-use-disorder-after-nonfatal-opioid-overdose-and-association-with-mortality-a-cohort-study
#1
Marc R Larochelle, Dana Bernson, Thomas Land, Thomas J Stopka, Na Wang, Ziming Xuan, Sarah M Bagley, Jane M Liebschutz, Alexander Y Walley
Background: Opioid overdose survivors have an increased risk for death. Whether use of medications for opioid use disorder (MOUD) after overdose is associated with mortality is not known. Objective: To identify MOUD use after opioid overdose and its association with all-cause and opioid-related mortality. Design: Retrospective cohort study. Setting: 7 individually linked data sets from Massachusetts government agencies...
June 19, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29913514/overdose-prevention-through-medical-treatment-of-opioid-use-disorders
#2
Nora D Volkow, Eric M Wargo
No abstract text is available yet for this article.
June 19, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29913484/medicines-for-patients-after-an-opioid-overdose
#3
(no author information available yet)
No abstract text is available yet for this article.
June 19, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29911961/liver-donation-after-brain-death-following-intentional-ingestion-of-99-e-cigarette-liquid-nicotine-10-ml
#4
Jinwoong Lee, Yeonho You, Jung Soo Park, Jin Hong Min, Insool Yoo, Wonjoon Jeong, Yongchul Cho, Seung Ryu, Seungwhan Kim, Sung Uk Cho, Se Kwang Oh, Junwan Lee, Hong Joon Ahn, Sang Min Jung
Incidences of brain death due to nicotine overdose by e-cigarettes have been increasing. In such cases, liver donation has been not reported because of the secondary damage to the liver due to metabolism of large amounts of nicotine. However, kidneys have been considered acceptable for transplant. Here, we present a successful case of liver transplant from a brain-dead donor due to intentional nicotine ingestion who did not have extensive steatosis. To the best of our knowledge, this is the first report of such a case...
June 18, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29911822/at-a-glance-lessons-learned-from-launching-the-manitoba-take-home-naloxone-program
#5
Songul Bozat-Emre, Shelley G Marshall, Colin Zhong, Joss Reimer
The Government of Manitoba launched the provincial Take-Home Naloxone Program in January 2017. By the end of September 2017, there were over 60 sites operating in Manitoba. These sites distributed 765 kits to people at risk of opioid overdose, and 93 of these kits were replacement kits used in overdose events. Most of these events occurred among males (60.2%) and in a private residence (72.0%). Fentanyl and carfentanil were the most common substances reported during overdose events. Take-Home Naloxone Program data provide important information about the unique context of the opioid crisis in Manitoba...
June 2018: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/29911821/at-a-glance-impact-of-drug-overdose-related-deaths-on-life-expectancy-at-birth-in-british-columbia
#6
Xibiao Ye, Jenny Sutherland, Bonnie Henry, Mark Tyndall, Perry Robert William Kendall
We quantified the contributions of leading causes of death and drug overdose to changes in life expectancy at birth over time and inequalities by sex and socioeconomic status in British Columbia. From 2014 to 2016, life expectancy at birth declined by 0.38 years and drug overdose deaths (mainly opioid-involved) contributed a loss of 0.12 years of the decrease. The analysis also demonstrated that the higher drug overdose mortality among males and among those in lower socioeconomic status communities contributed to a differential decrease in life expectancy at birth for males and for those in the latter category...
June 2018: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/29911684/insurance-companies-fighting-the-peer-review-empire-without-any-validity-the-case-for-addiction-and-pain-modalities-in-the-face-of-an-american-drug-epidemic
#7
K Blum, W Jacobs, E J Modestino, N DiNubile, D Baron, T McLaughlin, D Siwicki, I Elman, M Moran, E R Braverman, P K Thanos, R D Badgaiyan
The United States are amid an opioid overdose epidemic; we are challenged to provide non-addicting/non-pharmacological alternatives to assist in pain attenuation. There are proven strategies available to manage chronic pain effectively without opioids. Utilization review providers for insurance companies often ignore medicine based scientific peer-reviewed studies that warn against the chronic use of opioid medications, as well as the lack of evidence to support long-term use of opioids for pain. This paradigm must change if we are to indeed change the drug-embracing culture in American chronic pain management...
October 4, 2018: SEJ Surg Pain
https://www.readbyqxmd.com/read/29911619/the-effect-of-tail-docking-in-neonatal-pigs-on-the-central-expression-of-genes-involved-in-modulating-anxiety-like-behaviour
#8
P Oberst, D A Sandercock, P Di Giminiani, S A Edwards, P J Brunton
Background Adverse experiences in early life, such as exposure to stress, can have long term detrimental effects on the future physiology and behaviour of the animal. Typically animals exposed to such experiences are more anxious and more reactive to stress in later life. Tail biting is a major problem in modern pig production, both in terms of animal welfare and productivity. Tail docking in early postnatal life is common practice to reduce risk of this problem, but causes pain and may alter pain sensitivity...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29910726/-n-palmitoylethanolamine-supplementation-for-long-lasting-low-dosed-morphine-antinociception
#9
Lorenzo Di Cesare Mannelli, Laura Micheli, Elena Lucarini, Carla Ghelardini
The facilitation of opioid medication is eliciting a nemetic problem since increasing overdose deaths involve prescription of opioid pain relievers. Chronic painful diseases require higher doses of opioids, progressively with the development of tolerance to the antinociceptive effect. Novel strategies for the maintenance of low dosed opioid effectiveness are necessary to relieve pain and decrease abuse, overdose, and side effects. N -Palmitoylethanolamine (PEA) is an endogenous compound able to preserve the homeostasis of the nervous system and to delay the development of morphine tolerance...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29910015/developing-an-opioid-use-disorder-treatment-cascade-a-review-of-quality-measures
#10
Arthur Robin Williams, Edward V Nunes, Adam Bisaga, Harold A Pincus, Kimberly A Johnson, Aimee N Campbell, Remien H Remien, Stephen Crystal, Peter D Friedmann, Frances R Levin, Mark Olfson
BACKGROUND: Despite increasing opioid overdose mortality, problems persist in the availability and quality of treatment for opioid use disorder (OUD). Three FDA-approved medications (methadone, buprenorphine, and naltrexone) have high quality evidence supporting their use, but most individuals with OUD do not receive them and many experience relapse following care episodes. Developing and organizing quality measures under a unified framework such as a Cascade of Care could improve system level practice and treatment outcomes...
August 2018: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29909934/community-pharmacies-as-access-points-for-addiction-treatment
#11
Kevin A Look, Mercedes Kile, Katie Morgan, Andrew Roberts
BACKGROUND: There is growing interest in utilizing community pharmacies to support opioid abuse prevention and addiction treatment efforts. However, it is unknown whether the placement of community pharmacies is conducive to taking on such a role. OBJECTIVE: To examine the distribution of community pharmacies in Wisconsin and its relationship with the location of addiction treatment facilities and opioid-related overdose events in rural and urban areas. METHODS: The total number of opioid-related overdose deaths and crude death rates per 100,000 population were determined for each county in Wisconsin...
June 12, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29909220/worse-than-cell-lysis-the-resilience-of-oscillatoria-sp-during-sludge-storage-in-drinking-water-treatment
#12
Jiongming Sun, Hangzhou Xu, Haiyan Pei, Yan Jin, Hongmin Li, Chunxia Ma
Benthic Oscillatoria sp. may form dense surface blooms especially under eutrophic and calm conditions, which poses a threat to drinking water safety because it can produce toxic and odorous metabolites. This is the first study to investigate the effect of the conventional coagulant polyaluminium ferric chloride (PAFC) on removal of Oscillatoria sp., and the behavior of Oscillatoria sp. cells in sludges formed from different dosages of PAFC (control, optimum, and overdose system) during storage was also studied...
June 9, 2018: Water Research
https://www.readbyqxmd.com/read/29908763/acceptability-and-feasibility-of-naloxone-prescribing-in-primary-care-settings-a-systematic-review
#13
REVIEW
Emily Behar, Rita Bagnulo, Phillip O Coffin
Naloxone access through established healthcare settings is critical to responding to the opioid crisis. We conducted a systematic review to assess the acceptability and feasibility of prescribing naloxone to patients in primary care. We queried PubMed, EmBase and CINAHL for US-based, peer-reviewed, full-length, original articles relating to acceptability or feasibility of prescribing naloxone in primary care. Searches yielded 270 unduplicated articles; one analyst reviewed all titles and abstracts. Two analysts independently reviewed eligible articles for study design, study outcome, and acceptability and/or feasibility...
June 14, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29908435/brivaracetam-induced-elevation-of-carbamazepine-epoxide-levels-a-post-hoc-analysis-from-the-clinical-development-program
#14
Martin J Brodie, Toufic Fakhoury, Belinda McDonough, Anny-Odile Colson, Armel Stockis, Sami Elmoufti, John Whitesides
To assess the association, if any, between brivaracetam (BRV)-induced elevated carbamazepine-10,11-epoxide (CBZ-E) and toxicity and efficacy in patients with epilepsy. Data were pooled from three double-blind, placebo-controlled, Phase III studies of adjunctive BRV in adults with uncontrolled focal seizures (N01252/NCT00490035, N01253/NCT00464269, N01358/NCT01261325). Treatment-emergent adverse events (TEAEs) of interest (ataxia, diplopia, dizziness, nystagmus, somnolence, accidental overdose or poisoning, and toxicity), discontinuations due to TEAEs, and serious TEAEs (SAEs) were assessed in subgroups who did/did not receive carbamazepine (CBZ) at study entry (CBZ+ and CBZ-)...
June 4, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29908410/beyond-the-walls-risk-factors-for-overdose-mortality-following-release-from-the-philadelphia-department-of-prisons
#15
Lia N Pizzicato, Rebecca Drake, Reed Domer-Shank, Caroline C Johnson, Kendra M Viner
BACKGROUND: High overdose mortality after release from state prison systems is well documented; however, little is known about overdose mortality following release from local criminal justice systems (CJS). The purpose of this study was to assess overdose mortality following release from a local CJS in Philadelphia, PA. METHODS: We conducted a retrospective cohort study of individuals released to the community from a local CJS between 2010 and 2016. Incarceration records were linked to overdose fatality data from the Medical Examiner's Office and death certificate records...
June 5, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29908244/prompt-treatment-with-uridine-triacetate-improves-survival-and-reduces-toxicity-due-to-fluorouracil-and-capecitabine-overdose-or-dihydropyrimidine-dehydrogenase-deficiency
#16
Rolando A G Garcia, Joel A Saydoff, Michael K Bamat, Reid W von Borstel
Uridine triacetate has been shown to be an effective antidote against mortality and toxicity caused by either overdoses or exaggerated susceptibility to the widely used anticancer agents 5-fluorouracil (5-FU) and capecitabine. However, a direct assessment of efficacy based on when emergency treatment was initiated was not clinically feasible. In this study we used mouse models of 5-FU overdose and of dihydropyrimidine dehydrogenase (DPD) deficiency to compare the efficacy of uridine triacetate in reducing toxicity and mortality when treatment was initiated at time points from 4 to 144 h after administration of 5-FU...
June 13, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29908137/personality-high-risk-behaviors-and-elevated-risk-of-unintentional-deaths-related-to-drug-poisoning-among-individuals-with-spinal-cord-injury
#17
James S Krause, Yue Cao, Nicole D DiPiro, Emma Cuddy
OBJECTIVE: To identify risk and protective factors for unintentional death related to drug poisoning from prescription medications, including opioid-related deaths, and death due to all other causes among participants with spinal cord injury (SCI). DESIGN: Prospective cohort study. SETTING: Large specialty hospital in the Southeastern United States. PARTICIPANTS: Two cohorts of SCI participants, totaling 3070 adults (>18 years old) with chronic (>1 year) traumatic SCI...
June 13, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29908097/n-n-bis-2-mercaptoethyl-isophthalamide-binds-electrophilic-paracetamol-metabolites-and-prevents-paracetamol-induced-liver-toxicity
#18
Johan L Å Nilsson, Anders Blomgren, Ulf J Nilsson, Edward D Högestätt, Lars Grundemar
Paracetamol overdosing may cause liver injury including fulminant liver failure due to generation of the toxic metabolites, N-acetyl-p-benzoquinone imine (NAPQI) and p-benzoquinone (p-BQ). Herein, the chelating agent, N,N'-Bis(2-mercaptoethyl)isophthalamide (NBMI), was examined for its potential ability to entrap NAPQI and p-BQ and to prevent paracetamol-induced liver injury. Both NBMI and the conventional paracetamol antidote N-Acetyl cysteine (NAC) were investigated with regard to their abilities to scavenge the NAPQI and p-BQ in a Transient Receptor Potential Ankyrin 1 (TRPA1)-dependent screening assay...
June 16, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29904293/ah-7921-a-review-of-previously-published-reports
#19
REVIEW
Kerry Anne Rambaran, Zubair M Amin, Steven W Fleming, Liza Chacko, Saeed K Alzghari
AH-7921 is a synthetic opioid that was developed in the early 1970s. It has resulted in several fatal and nonfatal intoxications, despite not having approval from the US Food and Drug Administration. To date, AH-7921 is listed as a schedule I drug, and there have been no clinical trials exploring the safety of AH-7921. Herein, we provide an analysis of existing case reports available in the literature regarding AH-7921. We searched PubMed, Scopus, Web of Science, and EBSCO for articles (up until December 2017) using the terms "AH-7921" and "AH7921...
July 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29903025/to-propose-adding-index-of-achievement-ioa-to-imrt-qa-process
#20
Dong-Su Kim, Siyong Kim, Seong-Hee Kang, Tae-Ho Kim, So-Hyun Park, Kyeong-Hyeon Kim, Min-Seok Cho, Dong-Seok Shin, Yu-Yun Noh, Jin-Beom Chung, Tae Suk Suh
BACKGROUND: In intensity modulated radiation therapy (IMRT) quality assurance (QA), evaluation of QA result using a pass/non-pass strategy under an acceptance criterion often suffers from lack of information on how good the plan is in absolute manner. In this study, we suggested adding an index system, previously developed for dose painting technique, to current IMRT QA process for better understanding of QA result. METHODS: The index system consists of three indices, index of achievement (IOA), index of hotness (IOH) and index of coldness (IOC)...
June 15, 2018: Radiation Oncology
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