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https://www.readbyqxmd.com/read/28329602/glycopyrrolate-induced-craniofacial-compensatory-hyperhidrosis-successfully-treated-with-oxybutynin-report-of-a-novel-adverse-effect-and-subsequent-successful-treatment
#1
Megan E Prouty, Ryan Fischer, Deede Liu
Hyperhidrosis, or abnormally increased sweating, is a condition that may have a primary or secondary cause. Usually medication- induced secondary hyperhidrosis manifests with generalized, rather than focal sweating. We report a 32-year-old woman with a history of palmoplantar hyperhidrosis for 15 years who presented for treatment and was prescribed oral glycopyrrolate. One month later, the palmoplantar hyperhidrosis had resolved, but she developed new persistent craniofacial sweating. After an unsuccessful trial of clonidine, oxybutynin resolved the craniofacial hyperhidrosis...
October 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28318360/axillary-hyperhidrosis-a-focused-review
#2
Jason E Sammons, Amor Khachemoune
Axillary hyperhidrosis is characterized by an increased amount of sweat production, localized to the armpits, to compensate for environmental conditions and to control thermoregulation. It affects about 3.12% of the US population. It has a significant effect on one's psychological and physical health, as well as one's occupational life. The objective of this paper is to review the epidemiology, clinical presentation, pathophysiology, histology, and genetics, and management and treatment of axillary hyperhidrosis...
March 20, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28314788/the-parp-inhibitor-veliparib-can-be-safely-added-to-bendamustine-and-rituximab-and-has-preliminary-evidence-of-activity-in-b-cell-lymphoma
#3
Jacob D Soumerai, Andrew D Zelenetz, Craig Moskowitz, M Lia Palomba, Paul A Hamlin, Ariela Noy, David J Straus, Alison J Moskowitz, Anas Younes, Matthew J Matasar, Steven Horwitz, Carol Portlock, Jason Konner, Mrinal M Gounder, David M Hyman, Martin H Voss, Matthew G Fury, Devika Gajria, Richard D Carvajal, Alan L Ho, Jan H Beumer, Brian Kiesel, Zhigang Zhang, Alice Chen, Richard F Little, Christine Jarjies, Thu O Dang, Fallon France, Nishant Mishra, John F Gerecitano
PURPOSE: The PARP inhibitor veliparib enhances the cytotoxicity of alkylating agents. This phase 1 study evaluated veliparib with the bifunctional alkylator bendamustine (VB) in patients with relapsed/refractory lymphoma, multiple myeloma, and solid malignancies, with a cohort expansion of VB with rituximab (VBR) in patients with B-cell lymphomas. EXPERIMENTAL DESIGN: This dose-escalation study evaluated safety, pharmacokinetics and preliminary efficacy of veliparib (20-400 mg BID, days 1-7 of 28-day cycle) and bendamustine (70 and 90 mg/m2 IV, days 1 and 2)...
March 17, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28300854/randomized-placebo-and-active-controlled-crossover-study-of-the-safety-and-efficacy-of-thvd-102-a-fixed-dose-combination-of-oxybutynin-and-pilocarpine-in-subjects-with-primary-focal-hyperhidrosis
#4
David M Pariser, Janakan Krishnaraja, Thomas M Tremblay, R Michael Rubison, Ted W Love, Benjamin F McGraw
BACKGROUND: While muscarinic antagonists (anticholinergics) have shown efficacy in treating primary focal hyperhidrosis (PFH), side effects - most commonly dry mouth - are intolerable for most patients. THVD-102, a fixed-dose combination product has been developed combining oxybutynin, a muscarinic antagonist, and pilocarpine, a muscarinic agonist. The pilocarpine is at a dose level and release profile optimized to correct salivary flow impaired by oxybutynin yet not interfere with the therapeutic muscarinic antagonist effect of oxybutynin upon the sweat glands...
February 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28299626/efficacy-and-safety-of-escitalopram-in-treatment-of-severe-depression-in-chinese-population
#5
Tianmei Si, Gang Wang, Fude Yang, Yiru Fang, Maosheng Fang, Jijun Li, Jicheng Dong, Xinhua Shen, Jianmin Zhuo, Qing Rui, Jinan Wang, Hu Cuili
Severe depression accounts for one-third of depressed patients. Increasing severity of depression usually hinders patients from achieving remission. This study evaluated the efficacy and safety of escitalopram in acute-phase treatment of severe major depressive disorder (MDD). A total of 225 participants with severe MDD (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition criteria), with a current depressive episode and Montgomery-Asberg Depression Rating Scale (MADRS) score of ≥30 were enrolled...
March 15, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28295246/pourfour-du-petit-syndrome-associated-with-right-eye-pressure
#6
Randolph W Evans, Adam Garibay, Rod Foroozan
Pourfour du Petit (PDP) syndrome is a rare disorder characterized by ipsilateral mydriasis, eyelid retraction, and hemifacial hyperhidrosis caused by hyperactivity of the ipsilateral oculosympathetic pathway. A case is presented of PDP syndrome associated with likely ipsilateral occipital neuralgia. We review the causes and co-morbidities and the clinical features of PDP.
March 13, 2017: Headache
https://www.readbyqxmd.com/read/28284421/microwave-treatment-for-axillary-hyperhidrosis-and-bromhidrosis
#7
I Sánchez-Carpintero, A Martín-Gorgojo, R Ruiz-Rodríguez
Axillary hyperhidrosis (AH) and bromhidrosis are common causes of consultation in dermatology. Currently, the most widely prescribed treatment for AH is botulinum toxin, a very effective but temporary option; it is totally ineffective in bromhidrosis. Sympathectomy is an increasingly infrequent choice of treatment due to the high incidence of compensatory hyperhidrosis. We describe the treatment of AH and bromhidrosis with a novel microwave device that can fibrose eccrine and apocrine glands, achieving possibly permanent results...
March 8, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28282662/r3-versus-r4-thoracoscopic-sympathectomy-for-severe-palmar-hyperhidrosis
#8
Wenxiong Zhang, Yiping Wei, Han Jiang, Jianjun Xu, Dongliang Yu
Background Thoracoscopic sympathectomy (TS) was the preferred surgical treatment for palmar hyperhidrosis (PH), but postoperative complications such as compensatory sweating (CS) were common. This study was projected to compare R3 versus R4 TS for treating severe PH. Methods From April 2009 and March 2015, 106 consecutive patients with severe PH underwent bilateral R3 (n = 62) or R4 (n = 44) TS at The Second Affiliated Hospital of Nanchang University. The patients were followed up to evaluate symptom resolution, postoperative complications, satisfaction level, and severity of CS...
March 10, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28282661/influence-of-body-mass-index-on-compensatory-sweating-in-patients-after-thoracic-sympathectomy-due-to-palmar-hyperhidrosis
#9
Lukasz Dobosz, Natalia Cwalina, Tomasz Stefaniak
Background Thoracic sympathectomy (TS) is one of the most effective methods of treatment of primary hyperhidrosis. One of the side effects of this procedure is compensatory sweating (CS). Objective The aim of our study was to evaluate the influence of body mass index (BMI) on CS in patients after TS due to palmar hyperhidrosis. Methods Data from 157 patients with palmar hyperhidrosis who underwent TS were collected. The patients were subsequently divided in two groups according to their initial BMI: group A, BMI < 25 kg/m(2), and group B, BMI ≥ 25 kg/m(2)...
March 10, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28281850/a-systematic-review-of-microwave-based-therapy-for-axillary-hyperhidrosis
#10
Tzu-Herng Hsu, Yu-Tsung Chen, Yu-Kang Tu, Chien-Nien Li
OBJECTIVE: To systematically analyze the literature on the use of the microwave-based device for subdermal thermolysis of the axilla and its efficacy for the treatment of axillary hyperhidrosis. MATERIALS AND METHODS: A systematic review was conducted using PubMed, Embase, SCOPUS, and Cochrane databases on June 2, 2016. The inclusion criteria including: 1) studies with human subjects, 2) full-text articles published in English, 3) a microwave-based device used to treat axillary hyperhidrosis, and 4) trials that precisely evaluated axillary hyperhidrosis...
March 10, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28273934/a-systematic-review-and-meta-analysis-of-t2-t3-or-t4-to-evaluate-the-best-denervation-level-for-palmar-hyperhidrosis
#11
Wenxiong Zhang, Dongliang Yu, Yiping Wei, Jianjun Xu, Xiaoqiang Zhang
We systematically reviewed and compared the clinical outcomes of thoracoscopic sympathectomy (TS) at different denervation levels for palmar hyperhidrosis. We searched PubMed, Ovid MEDLINE, EMBASE, Web of Science, ScienceDirect, the Cochrane Library, Scopus and Google Scholar for relevant studies published during 1990-2016. Symptom resolution, patient satisfaction, compensatory sweating (CS), recurrence, dry hands and gustatory sweating were assessed. We selected 13 studies from 2228 for the final analysis...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28273218/comparison-between-high-and-low-levels-thoracic-sympathectomy-for-the-treatment-of-palmar-and-axillary-primary-hyperhidrosis-systematic-review-and-meta-analysis
#12
Gilmar Felisberto Júnior, Cláudio José Rubira, João Paulo Sanches Berumudes, Salum Bueno DA-Silveira-Júnior
Primary hyperhidrosis (PH) is a condition that has a great impact on affected individuals' quality of life, regardless of its location. Its surgical treatment is done through thoracic sympathectomy performed by videothoracoscopy. Standardization of the technique includes section of the sympathetic trunk at different levels, according to the site of symptoms. The aim of this review is to evaluate the efficacy of thoracic sympathectomy through a systematic literature review comparing sympathectomy at different levels of the sympathetic chain...
December 2016: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28244893/methadone-induced-hyperhidrosis-treated-with-oxybutynin
#13
Joe Hong, Jooyeon Lee, Holly Totouom-Tangho, Norma Ramos Dunn, Ronnie Gorman Swift
OBJECTIVES: This case report aims to help healthcare providers and methadone clinic patients to recognize one of the less recognized adverse effects of methadone, hyperhidrosis, and to suggest oxybutynin as a possible solution. METHODS: A 35-year-old man on methadone maintenance therapy presented with excessive sweating, which began promptly after methadone was introduced. Urine toxicology was conducted every 2 weeks to rule out other illicit substances that may have contributed to the sweating...
February 27, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28241332/osteopathic-manipulative-treatment-in-the-management-of-isaacs-syndrome
#14
Lisa K T Shanahan, Selena G M Raines, Rachel L Coggins, Teanna Moore, Michael Carnes, Laura Griffin
Isaacs syndrome is a rare neuromuscular disorder characterized by chronic muscle stiffness, cramping, fasciculations, myokymia, and hyperhidrosis. Pathogenesis includes autoimmunity, paraneoplastic disorders, genetic predisposition, or toxin exposure. There is no known cure for Isaacs syndrome. This case report describes a patient who had been given the diagnosis of Isaacs syndrome and received osteopathic manipulative treatment to manage fascial and cranial dysfunctions and reduce nervous system hyperexcitability...
March 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28159584/botulinum-toxin-in-the-management-of-head-and-neck-disorders
#15
REVIEW
Ravleen Nagi, Deepa Jatti Patil, Shashikant Sahu, Supreet Jain, Giridhar S Naidu
Botulinum toxin is a polypeptide protoxin synthesized by Clostridium botulinum that results in localized reduction of muscle activity by inhibiting acetylcholine release at the neuromuscular junction. In 2004, the US Food and Drug Administration approved its application in the treatment of various medical conditions, such as facial wrinkles, strabismus, cervical dystonia, blepharospasm, and hyperhidrosis. Later, its application extended to improving dental esthetics and gummy smile. It was found to be a safe and effective alternative to medical therapy to treat various head and neck disorders that have a neurologic component...
December 7, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28132703/drug-safety-and-adverse-drug-reaction-reporting-behavior-related-to-outpatient-opioid-replacement-therapy-results-from-a-survey-among-physicians
#16
Maximilian Gahr, Jonas Eller, Maurice Cabanis, Christoph Hiemke, Roland W Freudenmann, Bernhard J Connemann, Dirk Lang, Carlos Schönfeldt-Lecuona
To study drug safety and the reporting behavior of adverse drug reactions (ADR) related to agents used for opioid replacement therapy (ORT) we conducted a cross-sectional questionnaire-based telephone survey among physicians who provide outpatient ORT in Germany (n=176; response rate=55.7%). Most respondents (n=97/55.1%) reported that they observe ADR related to buprenorphine, (dihydro)codeine, and (levo)methdone rarely (n=38/21.6%), very rarely (n=39/22.2%) or never (n=20/11.4%). Methadone was reported to be most frequently associated with the occurrence of ADR (n=82/46...
March 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28111784/myaesthenia-gravis-exacerbation-caused-by-axillary-injection-of-botulinum-toxin-a-for-treatment-of-hyperhidrosis
#17
S El-Heis, G Burke, W Gibb, M R Ardern-Jones
No abstract text is available yet for this article.
January 23, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28106275/initial-study-of-transdermal-oxybutynin-for-treating-hyperhidrosis
#18
José Francisco Millán-Cayetano, Javier Del Boz, Tomas Toledo-Pastrana, Miriam Nieto-Guindo, Pablo García-Montero, Magdalena de Troya-Martín
Oral oxybutynin for treating hyperhidrosis is effective and safe. Its side-effects are mild but frequent so we consider whether transdermal oxybutynin (considered to have a better side-effect profile) could be an alternative for treating hyperhidrosis. During 2015, a prospective study was conducted. Epidemiological variables, effectiveness (using the Hyperhidrosis Disease Severity Scale) and tolerance to transdermal oxybutynin were compiled concerning two different groups (patients previously treated or untreated with oral oxybutynin), at baseline, and at 3 and 12 months...
January 20, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28104284/-fabry-disease
#19
F Stephan, R Haber
Fabry disease, also known as Anderson-Fabry disease or angiokeratoma corporis diffusum universale, is an X-linked recessive form of sphingolipidosis caused by total or partial deficiency of the lysosomal hydrolase, alpha-galactosidase A. From the youngest age, it results in a gradual ubiquitous build-up of glycosphingolipids that are not degraded by the missing enzyme. Cutaneous, neurological, nephrologic, cardiac, gastrointestinal, ophthalmological, respiratory, cochleovestibular and haematological involvement are responsible for increased mortality and significant impairment of quality of life in subjects affected by the disease...
February 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28099590/palmar-hyperhidrosis-clinical-pathophysiological-diagnostic-and-therapeutic-aspects
#20
Flávio Ramalho Romero, Gabriela Roncada Haddad, Hélio Amante Miot, Daniele Cristina Cataneo
Palmar hyperhidrosis affects up to 3% of the population and inflict significant impact on quality of life. It is characterized by chronic excessive sweating, not related to the necessity of heat loss. It evolves from a localized hyperactivity of the sympathetic autonomic system and can be triggered by stressful events. In this study, the authors discuss clinical findings, pathophysiological, diagnostic and therapeutic issues (clinical and surgical) related to palmar hyperhidrosis.
November 2016: Anais Brasileiros de Dermatologia
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