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https://www.readbyqxmd.com/read/28099590/palmar-hyperhidrosis-clinical-pathophysiological-diagnostic-and-therapeutic-aspects
#1
Flávio Ramalho Romero, Gabriela Roncada Haddad, Hélio Amante Miot, Daniele Cristina Cataneo
Palmar hyperhidrosis affects up to 3% of the population and inflict significant impact on quality of life. It is characterized by chronic excessive sweating, not related to the necessity of heat loss. It evolves from a localized hyperactivity of the sympathetic autonomic system and can be triggered by stressful events. In this study, the authors discuss clinical findings, pathophysiological, diagnostic and therapeutic issues (clinical and surgical) related to palmar hyperhidrosis.
November 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28093070/clonidine-is-effective-for-the-treatment-of-primary-idiopathic-hyperhidrosis-and-hot-flushes-a-case-report
#2
Ahmed Albadrani
BACKGROUND: While primary hyperhidrosis can be seen in men, accompanying hot flushes is rarely seen in men. Primary hyperhidrosis is thought to be related to overactivity of the sympathetic nervous system while hot flushes are believed to be related to altered peripheral vascular reactivity and a narrowed thermoregulatory zone. CASE PRESENTATION: I report the case of a 29-year-old man of Arab origin who presented to a dermatology clinic with a complaint of generalized sweating, with heavier involvement of his inguinal region, axilla, and lower back...
January 17, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28063525/the-impact-of-skin-diseases-on-quality-of-life-a-multicenter-study
#3
G Sanclemente, C Burgos, J Nova, F Hernández, C González, M I Reyes, N Córdoba, Á Arévalo, E Meléndez, J Colmenares, S Ariza, G Hernández
INTRODUCTION: To date, no formal study has been published regarding how Colombian patients with skin disorders could be affected according to their perception of disease. OBJECTIVE: To determine the impact in quality of life of skin diseases in a Colombian population. METHODS: This multicenter study included patients with skin disease from almost the whole country. Individuals >18 years old; of any gender; with any skin disease and who signed informed consent, were included...
January 4, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28043867/bont-ab-hybrid-maintains-similar-duration-of-paresis-as-bont-a-wild-type-in-murine-running-wheel-assay
#4
Anna Kutschenko, Marie-Christine Reinert, Nadja Krez, David Liebetanz, Andreas Rummel
The highly potent Botulinum neurotoxins (BoNT) are successful drugs to treat neuromuscular disorders. Efforts are being made to further reduce the injected BoNT dose and to lengthen the interval between treatments. Detailed knowledge of the BoNT structure-activity relationship (SAR) allows combining the best features of the different BoNT serotypes. Of all seven BoNT serotypes A-G, BoNT/A displays the highest potency despite low neuronal binding affinity, while BoNT/B exhibits much higher affinity. Recently, a new BoNT/AB hybrid (AABB) was constructed comprising the catalytic and translocation domain of BoNT/A and the 50kDa cell binding domain of BoNT/B...
December 30, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/28025408/a-case-of-anti-aquapolin-4-antibody-positive-myelitis-with-hyperhidrosis-following-herpes-zoster
#5
Machiko Suda, Michiko Tsutsumiuchi, Yoshikazu Uesaka, Nobukazu Hayashi
We report an acute myelitis in a 53-year-old woman that occurred in 7 days after the diagnosis of Th5-6 herpes zoster. Clinical examination revealed hyperhidrosis of left side of her face, neck, arm and upper chest. She also had muscle weakness of her left leg and sensory impairment for light touch and temperature in her chest and legs. Spinal cord MRI demonstrated a longitudinal T2-hyperintense lesion extending from Th1 to 7. In the axial imaging, the lesion dominantly located in the left side gray matter...
December 23, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28009681/use-of-a-microwave-device-for-treatment-of-amputation-residual-limb-hyperhidrosis
#6
Kaitlyn N Mula, Jamal Winston, Sarah Pace, Joshua B Kentosh
No abstract text is available yet for this article.
January 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28001258/translation-and-validation-of-hyperhidrosis-disease-severity-scale
#7
Andrea Yasbek Monteiro Varella, Juliana Maria Fukuda, Marcelo Passos Teivelis, José Ribas Milanez DE Campos, Paulo Kauffman, Gabriel Grizzo Cucato, Pedro Puech-Leão, Nelson Wolosker
Introduction: The evaluation of patients with hyperhidrosis (HH) can be accomplished, among other ways, through questionnaires and scales. The Hyperhidrosis Disease Severity Scale (HDSS) has been used as a simple and quick tool to perform this evaluation. Although HDSS has been well established in several languages, it has not been translated into Portuguese, restricting its specific use for Brazilian patients. The aim of this study was to translate HDSS into Portuguese and validate it in a sample of Brazilian subjects...
December 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/27998860/-anesthetic-effect-and-safety-of-ultrasound-guided-thoracic-paravertebral-blockade-in-sympathectomy-for-palmar-hyperhidrosis-a-randomized-controlled-trial
#8
Jin-Dong Xu, Li-Na Yu, Da-Qiang Zhao, Liang Xie, Hai-Yu Zhou, Sheng Wang
OBJECTIVE: To explore the anesthetic effect and safety of ultrasound-guided thoracic paravertebral blockade in video-assisted thoracoscopic sympathectomy for treatment of palmar hyperhidrosis. METHODS: A total of 120 patients undergoing video-assisted thoracoscopic sympathectomy for moderate or severe hyperhidrosis were randomized to receive ultrasound-guided thoracic paravertebral blockade (group A, n=60) or general anesthesia with tracheal intubation (group B, n=60)...
December 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27990394/great-saphenous-vein-dilatation-with-reflux-at-the-saphenofemoral-junction-a-rare-underlying-association-of-eccrine-angiomatous-hamartoma
#9
Sanjiv Choudhary, Quazi Sabiha, Adarsh Lata Singh
Eccrine angiomatous hamartoma (EAH) is an exceedingly rare benign tumor-like lesion prevalent in childhood, which can produce pain and marked sweating. Histological features include proliferation of eccrine sweat glands and angiomatous capillary channels. It may be rarely associated with underlying pathological conditions. A 15-year-old female patient presented with multiple tender reddish papules and nodules coalescing to form plaques of 10 × 8 cm over the anterior aspect of the right lower thigh since birth...
November 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27982329/relationship-between-anxiety-depression-and-quality-of-life-with-the-intensity-of-reflex-sweating-after-thoracoscopic-sympathectomy-for-treatment-of-primary-hyperhidrosis
#10
Luciara Irene DE Nadai Dias, Eliana Cristina Martins Miranda, Ivan Felizardo Contrera Toro, Ricardo Kalaf Mussi
Objective: to compare the intensity of reflex sweating with the degree of anxiety and its interference in the quality of life of patients undergoing Thoracoscopic (VATS) sympathectomy in the pre- and postoperative period. Methods: we evaluated 54 patients with a mean age of 26 years (16-49 years) undergoing sympathectomy in the R3-R4 level. We applied two questionnaires at three different times: "Quality of life in patients with primary hyperhidrosis" and "Scale for anxiety and depression"...
September 2016: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/27976476/treatment-of-primary-hyperhidrosis-with-oral-anticholinergic-medications-a-systematic-review
#11
REVIEW
Lucinda Cruddas, Daryll M Baker
BACKGROUND: Primary hyperhidrosis is a condition characterised by excessive sweating. Patients are treated off-license with oral anticholinergic medications, and report adverse events associated with systemic anticholinergic interactions. OBJECTIVES: This review assesses clinical evidence of efficacy, impact on quality of life and adverse events associated with oral anticholinergic therapy for primary hyperhidrosis. METHODS: PRISMA guidelines were implemented to complete a systematic review (PROSPERO:CRD42016036326)...
December 15, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27924350/-use-of-intracutaneous-or-subcutaneous-botulinum-toxin-for-postherpetic-neuralgia
#12
L Halb, B J Amann, H Bornemann-Cimenti
BACKGROUND: Botulinum neurotoxin (BoNT), a toxin of the anaerobic spore-forming bacterium Clostridium botulinum is used as a drug for alleviating muscle spasticity. Other indications include the cosmetic application in facial muscles, hyperhidrosis and neurogenic bladder disorders. It has been approved since 2010 as the first prophylactic treatment for chronic migraine. The analgesic effect of BoNT was observed early on and is currently the subject of intensive research. Painful postherpetic neuralgia is a common complication of an infection with herpes zoster virus...
December 6, 2016: Der Nervenarzt
https://www.readbyqxmd.com/read/27912978/tap-water-iontophoresis-in-the-treatment-of-pediatric-hyperhidrosis
#13
Haitham Dagash, Sinead McCaffrey, Katie Mellor, Agnes Roycroft, Ingrid Helbling
AIM OF THE STUDY: The treatment options for localized hyperhidrosis include antiperspirants, anticholinergics, iontophoresis, botulinum toxin and surgery. Tap water iontophoresis (TWI) involves immersing the affected area in tap water and passing a small electrical current through the area. Our aim was to assess the success of this therapy in a pediatric cohort. METHODS: Retrospective case note review of all patients younger than 18years who underwent TWI between 2002 and 2015...
November 14, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27894764/thoracoscopic-bilateral-t3-sympathectomy-for-primary-focal-hyperhidrosis-in-children
#14
Pablo Laje, Kali Rhodes, Leanne Magee, Mary Kate Klarich
AIM OF THE STUDY: Present our experience in the surgical treatment of primary focal hyperhidrosis of the hands by thoracoscopic bilateral T3 sympathectomy in pediatric patients. METHODS: Retrospective chart review of all patients operated between 2013 and 2015. RESULTS: We operated and included in the study 28 patients, 22 females and 6 males. Mean age was 14 (6-21) years. All patients had previously tried at least one form of medical therapy with no success...
November 14, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27893541/treatment-of-palmar-hyperhidrosis-with-needle-injection-versus-low-pressure-needle-free-jet-injection-of-onabotulinumtoxina-an-open-label-prospective-study
#15
Sophie Vadeboncoeur, Vincent Richer, Mélissa Nantel-Battista, Antranik Benohanian
BACKGROUND: OnabotulinumtoxinA (OnabotA) injections are effective to treat palmar hyperhidrosis (HH) but are quite painful. OBJECTIVE: To evaluate efficacy and pain of OnabotA injection using a needle-free jet apparatus compared with the traditional needle injection to treat palmar HH. METHODS: Twenty patients were recruited for a prospective open-label study. Their right hand was injected with 1% lidocaine with a jet injector, after which OnabotA was injected with a needle...
November 23, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27889103/cardiac-autonomic-changes-after-thoracic-sympathectomy-a-prospective-randomized%C3%A2-study
#16
Alfonso Fiorelli, Giovanni Messina, Paolo Chiodini, Saveria Costanzo, Andrea Viggiano, Marcellino Monda, Giovanni Vicidomini, Mario Santini
BACKGROUND: We evaluated whether cardiac autonomic changes could be associated with different extent of sympathetic nerve resection in the management of essential palmar hyperhidrosis. METHODS: Sixty patients with essential palmar hyperhidrosis were randomly allocated to undergo excision of T3 ganglia (sympathicectomy group; n = 30) or to interruption of sympathetic chain at the T2 to T3 level with ganglion sparing (sympathicotomy group; n = 30). Time and frequency domains were measured with a 24-Holter monitor during daytime, nighttime, and 24-hour periods at different interval points (7 days before operation; 24 hours; and 1, 3, and 6 months later), and the differences were statistically compared...
January 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27881089/abnormal-primary-and-permanent-dentitions-with-ectodermal-symptoms-predict-wnt10a-deficiency
#17
Birgitta Bergendal, Johanna Norderyd, Xiaolei Zhou, Joakim Klar, Niklas Dahl
BACKGROUND: The WNT10A protein is critical for the development of ectodermal appendages. Variants in the WNT10A gene may be associated with a spectrum of ectodermal abnormalities including extensive tooth agenesis. METHODS: In seven patients with severe tooth agenesis we identified anomalies in primary dentition and additional ectodermal symptoms, and assessed WNT10A mutations by genetic analysis. RESULTS: Investigation of primary dentition revealed peg-shaped crowns of primary mandibular incisors and three individuals had agenesis of at least two primary teeth...
November 24, 2016: BMC Medical Genetics
https://www.readbyqxmd.com/read/27879523/prevalence-of-multifocal-primary-hyperhidrosis-and-symptom-severity-over-time-results-of-a-targeted-survey
#18
Dee Anna Glaser, Angela M Ballard, Niquette L Hunt, Lisa J Pieretti, David M Pariser
BACKGROUND: There is a paucity of data on the prevalence of multifocal primary hyperhidrosis and changes in hyperhidrosis severity over time. OBJECTIVE: The goal of this study was to better understand multifocal primary hyperhidrosis, prevalence and distribution of hyperhidrosis by focal site, age of onset of symptoms by focal area, and change in hyperhidrosis severity over time and with seasons. MATERIALS AND METHODS: The International Hyperhidrosis Society, through an unrestricted research grant from Revance Therapeutics, conducted an online survey of registered visitors to its Web site...
December 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27878939/botulinum-toxin-a-for-palmar-hyperhidrosis-assessment-with-sympathetic-skin-responses-evoked-by-train-of-stimuli
#19
J Y Al-Hashel, D Youssry, H M Rashaed, T Shamov, R T Rousseff
Objective assessment of the effect of botulinum toxin A (BT) treatment in primary palmar hyperhidrosis (PH) is attempted by different methods. We decided to use for this purpose sympathetic skin responses evoked by train of stimuli (TSSR). Twenty patients with severe PH (five female, median age 24, range 18-36) were examined regularly over 3 months after receiving 50 UI BT in each palm. TSSR were recorded from the palms after sensory stimulation by a train of three supramaximal electric pulses 3 millisecond apart...
July 2016: Autonomic & Autacoid Pharmacology
https://www.readbyqxmd.com/read/27865628/the-genesis-and-presentation-of-anxiety-in-disorders-of-autonomic-overexcitation
#20
Andrew P Owens, David A Low, Valeria Iodice, Hugo D Critchley, Christopher J Mathias
INTRODUCTION: We investigated the genesis and presentation of previously-reported anxiety in disorders of autonomic overexcitation in relation to interoception, body vigilance and trauma to test our hypothesis that patients with the postural tachycardia syndrome (PoTS), vasovagal syncope (VVS) and essential hyperhidrosis (EH) represent atypical anxiety phenotypes in whom affective symptoms are more related to apprehension and vigilance of physiological (interoceptive) feedback than neurotic or trauma-related factors...
October 19, 2016: Autonomic Neuroscience: Basic & Clinical
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