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https://www.readbyqxmd.com/read/29142091/physiological-and-pathophysiological-firing-properties-of-single-postganglionic-sympathetic-neurons-in-humans
#1
Vaughan G Macefield, B Gunnar Wallin
It has long been known from microneurographic recordings in human subjects that activity of postganglionic sympathetic axons occurs as spontaneous bursts, with muscle sympathetic nerve activity (MSNA) exhibiting strong cardiac rhythmicity via the baroreflex and skin sympathetic nerve activity (SSNA) showing much weaker cardiac modulation. Here we review the firing properties of single sympathetic neurons, obtained using highly selective microelectrodes. Individual vasoconstrictor neurons supplying muscle or skin, or sudomotor neurones supplying sweat glands, always discharge with a low firing probability (~30%) and at very low frequencies (~0...
November 15, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29135528/postoperative-harlequin-syndrome-case-report-of-a-rare-but-clinically-striking-condition
#2
Ashley T Kydes, Ashley M Kelley, Samir R Pandya, Samuel M Barst
We present a case of a 2-year-old boy who underwent thoracoscopic resection of a left paraspinal mediastinal mass and developed Harlequin syndrome postoperatively. Harlequin syndrome is a rare neurological condition characterized by unilateral hyperhidrosis and erythema of the head and neck. Our discussion highlights this condition and other differential diagnoses that may present similarly in the postoperative period.
November 9, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/29128285/prolonged-and-localized-sweat-stimulation-by-iontophoretic-delivery-of-the-slowly-metabolized-cholinergic-agent-carbachol
#3
Phillip Simmers, S Kevin Li, Gerald Kasting, Jason Heikenfeld
BACKGROUND: Continuous non-invasive sampling and sensing of multiple classes of analytes could revolutionize medical diagnostics and wearable technologies, but also remains highly elusive because of the many confounding factors for candidate biofluids such as interstitial fluid, tears, saliva, and sweat. Eccrine sweat biosensing has seen a recent surge in demonstrations of wearable sampling and sensing devices. However, for subjects at rest, access to eccrine sweat is highly limited and unpredictable compared to saliva and tears...
November 8, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29110043/-axillary-and-perimamillary-fox-fordyce-disease-apocrine-miliaria-in-a%C3%A2-19-year-old-woman
#4
S Hanner, R Schneiderbauer, A Enk, F Toberer
Fox-Fordyce disease (FFD), also known as apocrine miliaria, is a rare and chronic skin disease characterized by itching and skin-colored, light brown or yellowish papules. FFD typically affects postpubertal young women between 13 and 35 years. The etiology is not completely known, but a hormonal component is in discussion. Furthermore, exacerbating factors like laser hair removal and hyperhidrosis have been described. Treatment of FFD is quite challenging, as the reported modalities mostly show limited success...
November 6, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29108909/a-novel-non-invasive-anesthetic-method-for-neurotoxin-injection-for-palmar-hyperhidrosis
#5
Lauren Lam, Susan Poelman
No abstract text is available yet for this article.
November 3, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29098567/oxycodone-naloxone-prolonged-release-a-review-in-severe-chronic-pain
#6
Esther S Kim
Oral oxycodone/naloxone prolonged release (PR) [Targin(®), Targinact(®), Targiniq(®)] is a 12-hourly opioid receptor agonist and opioid receptor antagonist fixed-dose combination product that is approved in countries in the EU for the management of severe pain (adequately manageable only with opioid analgesics) in adults. Oral naloxone prevents oxycodone from binding to μ-receptors in the gastrointestinal (GI) tract, thereby counteracting opioid-induced constipation (OIC). In short-term (5- to 12-week) clinical trials of adults with moderate to severe, chronic pain and OIC (OXN3001, OXN3006, OXN3506), oxycodone/naloxone PR significantly improved OIC while providing noninferior analgesia relative to oxycodone PR; results were consistent between cancer and non-cancer patients in OXN3506...
November 2, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29084148/neurophysiological-measures-of-efficacy-and-safety-for-botulinum-toxin-injection-in-facial-and-bulbar-muscles-special-considerations
#7
REVIEW
Mohammad Alimohammadi, Anna Rostedt Punga
Botulinum toxin (BoNT) injections into facial and bulbar muscles are widely and increasingly used as medical treatments for cervical and facial dystonia, facial hemispasm, correction of facial palsy, hyperhidrosis, as well as cosmetic treatment of glabellar lines associated with grief and anger. Although BoNT treatment is generally considered safe, the diffusion of the toxin to surrounding muscles may result in complications, including difficulties swallowing, in a dose-dependent manner. The sensitivity of clinical examination for detecting adverse events after BoNT treatment is limited...
October 30, 2017: Toxins
https://www.readbyqxmd.com/read/29067137/acupuncture-and-cutaneous-medicine-is-it-effective
#8
Mary van den Berg-Wolf, Thomas Burgoon
Background: In China, acupuncture has been used as a form of medical therapy for more than 2500 years. It is a part of traditional medical practice and is used to treat the entire spectrum of human and veterinary disease. Although dermatologic disease has received much less attention in worldwide acupuncture research than pain and musculoskeletal conditions, there is a growing body of evidence suggesting acupuncture's usefulness in this area. Objective: The aim of this article was to review the evidence in the literature regarding the usefulness of acupuncture in managing dermatologic illness...
October 1, 2017: Medical Acupuncture
https://www.readbyqxmd.com/read/29064982/lasers-and-energy-based-devices-in-men
#9
REVIEW
Milène K Crispin, George J Hruza, Suzanne L Kilmer
BACKGROUND: The demand for cosmetic treatments with lasers and energy-based devices has increased among men, but there is a dearth of literature that addresses the approach and treatment of cosmetic male patients. OBJECTIVE: To summarize common cosmetic concerns for which male patients seek cosmetic treatments and to provide sex-specific recommendations for the lasers and energy-based devices that can be used for treatment. MATERIALS AND METHODS: The authors conducted a literature search using the PubMed/MEDLINE and Google Scholar databases using the search terms male, men, gender, and cosmetic dermatology...
November 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29055158/a-phase-2a-randomized-controlled-study-to-evaluate-the-pharmacokinetic-safety-tolerability-and-clinical-effect-of-topically-applied-umeclidinium-in-subjects-with-primary-axillary-hyperhidrosis
#10
A Nasir, R Bissonnette, C Maari, J DuBois, T Pene Dumitrescu, J Haddad, Y Yamaguchi, M Dalessandro
BACKGROUND: Hyperhidrosis is a common medical condition which can have a significant impact on quality of life. Umeclidinium (UMEC) is a long acting muscarinic antagonist (LAMA) developed as a dermal formulation. OBJECTIVES: This 2-week, double-blind, randomized, vehicle-controlled study evaluated systemic exposure, safety, and tolerability of topically administered UMEC in subjects with primary axillary hyperhidrosis. Clinical effect was a secondary objective, measured by gravimetry and the hyperhidrosis disease severity scale (HDSS)...
October 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29049566/evaluation-of-patients-who-underwent-resympathectomy-for-treatment-of-primary-hyperhidrosis
#11
José Ribas Milanez de Campos, Lucas Lembrança, Juliana Maria Fukuda, Paulo Kauffman, Marcelo Passos Teivelis, Pedro Puech-Leão, Nelson Wolosker
OBJECTIVES: Video thoracoscopic sympathectomy is the recommended surgical treatment for primary hyperhidrosis and has a high success rate. Despite this high success rate, some patients are unresponsive and eventually need a resympathectomy. Few studies have previously analysed exclusively the results of these resympathectomies in patients with primary hyperhidrosis. None of the studies have objectively evaluated the degree of response to surgery or the improvement in quality of life after resympathectomies...
November 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29038880/ct-guided-percutaneous-ethanol-sympatholysis-for-primary-hyperhidrosis
#12
Malcolm Brock, Constantine Frangakis, Christos S Georgiades
PURPOSE: Primary hyperhidrosis (PH) typically involves the craniofacial (CF) or axillary-palmar (AP) region. Our purpose was to determine the safety and efficacy of CT-guided sympatholysis for treating PH. METHODS: In this prospective study, 39 consecutive patients with CF or AP PH were referred for percutaneous sympatholysis. Procedures were performed under CT guidance and minimal sedation. We treated level T2 for CF hyperhidrosis and T2, T3, and T4 for AP hyperhidrosis...
October 16, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29030680/-modern-non-cosmetic-treatment-with-botulinum-toxins
#13
REVIEW
A Straube
Botulinum toxin has been known in medical history for a long time. The first scientific investigations and thoughts on possible indications in the treatment of muscular disorders were published by the German physician and poet Justinus Kerner in 1822. The physiological effect of botulinum toxin was identified in the middle of the twentieth century and the first clinical use was reported in 1977. It was first used in ophthalmology for the correction of strabismus and some years later the therapy of blepharospasm and cervical dystonia was established...
October 13, 2017: Der Internist
https://www.readbyqxmd.com/read/29019534/evaluation-of-the-quality-of-life-of-patients-with-primary-hyperhidrosis-submitted-to-videothoracoscopic-sympathectomy
#14
Sandoval Lage da Silva, Rossano Kepler Alvim Fiorelli, Maria Ribeiro Santos Morard
OBJECTIVE: to evaluate the quality of life of patients undergoing video-assisted thoracoscopy for primary hyperhidrosis. METHODS: we evaluated the patients who underwent thoracoscopic sympathectomy to treat primary hyperhidrosis by the team of thoracic surgery at the University Hospital Gaffrée and Guinle - UNIRIO between July 2004 and August 2013. It was applied a questionnaire about quality of life related to hyperhidrosis since preoperative period until one year after the surgery...
July 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28993234/epidemiology-of-hyperhidrosis-in-2-population-based-health-care-databases
#15
Kristen Ricchetti-Masterson, J Morel Symons, Molly Aldridge, Ayush Patel, Joe Maskell, John Logie, Yuji Yamaguchi, Suzanne F Cook
BACKGROUND: Population-based and clinical case reports of hyperhidrosis (HH) provide prevalence estimates that vary widely across reported studies because of differences in case ascertainment. OBJECTIVE: In this study, we specify diagnostic, symptom, and prescription codes for HH to estimate incidence and prevalence for the United Kingdom and the United States. METHODS: Data from UK and US health care databases were analyzed to ascertain HH cases and estimate incidence and prevalence from health care records during calendar years 2011 through 2013...
October 6, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28985838/t3-versus-t4-thoracoscopic-sympathectomy-for-palmar-hyperhidrosis-a-meta-analysis-and-systematic-review
#16
REVIEW
Wenxiong Zhang, Yiping Wei, Han Jiang, Jianjun Xu, Dongliang Yu
BACKGROUND: Palmar hyperhidrosis (PH) is a benign sympathetic disorder that can adversely affect the quality of life of patients. Thoracic sympathectomy (TS) at the T3 or T4 level has been used to treat PH. We aimed to determine the optimal denervation level for TS by comparing the efficacy of T3 TS versus T4 TS in PH patients. METHODS: We searched the PubMed, Ovid MEDLINE, EMBASE, Web of Science, ScienceDirect, the Cochrane Library, Scopus, and Google Scholar databases for studies comparing T3 versus T4 TS for PH...
October 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28977371/resolution-of-generalized-compensatory-hyperhidrosis-related-to-sympathectomy-after-t2-sympatholysis
#17
Malcolm Brock, Christos S Georgiades
Compensatory hyperhidrosis (CH) is common after sympathectomy, and most treatments are ineffective. We present a 36-year-old man whose CH was effectively treated with percutaneous sympatholysis. The patient's axillary-palmar hyperhidrosis had been treated with T3-4 sympathetic ligation. The patient developed CH involving the head, face, back, torso and feet and was referred for computed tomography-guided percutaneous T2 sympatholysis for craniofacial symptoms, after which the patient experienced resolution of CH (complete face/neck/feet and partial back/torso), despite the treated level being above the previous ligation...
July 21, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28963390/acromegaly-with-hypophosphataemia-mccune-albright-syndrome
#18
Rimesh Pal, Pinaki Dutta, Kanchan Kumar Mukherjee, Anil Bhansali
A 38-year-old man presented with excessive height gain and progressive enlargement of the extremities since childhood. This was compounded by lower limb deformities over the past 5 years. On examination, his height was 196 cm, he had macroglossia, acral enlargement, seborrhoea, hyperhidrosis-suggesting acrogigantism. He had facial asymmetry, wind-swept deformity of lower limbs and a café-au-lait macule over his trunk. Investigations revealed normal-sized pituitary gland with dysplastic cranial bones. Isotope bone scintigraphy was suggestive of polyostotic fibrous dysplasia...
September 28, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28940663/a-novel-method-to-assess-the-potential-role-of-sweating-abnormalities-in-the-pathogenesis-of-ad
#19
Yurie Shimoda-Komatsu, Yohei Sato, Yoshimi Yamazaki, Ryo Takahashi, Tetsuo Shiohara
BACKGROUND: Although atopic dry skin is believed to be caused by defects in skin genes important for maintaining skin barrier function, the role of sweat in atopic dermatitis (AD) has been apparently underestimated. Given the great capacity of sweat to maintain and increase skin hydration, defective sweating responses may be a logical place to look for changes that predispose individuals to the disease. METHODS: We investigated how disease process and sweating defects progress from early asymptomatic stages to the onset of clinically apparent disease by employing the impression mold technique, which allows an accurate quantification of individual sweat gland/duct activity in relation to skin surface topography...
September 23, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28936748/quantity-and-quality-of-sweating-in-atopic-dermatitis
#20
Marlies Wruhs, Andreas Gleiß, Andreas Steiner, Paul Sator
Sweat may be an important factor in triggering an exacerbation of atopic dermatitis. It was the aim of this study to evaluate a possible correlation between atopic patients and hyperhidrosis-measured by a questionnaire-and to find out whether there are qualitative differences in sweat response-measured by sudomotor activity (sympathetic skin response test, SSR). Included were 100 study participants, of whom 50 were patients with atopic dermatitis and 50 were serving as control group. The frequency of hyperhidrosis is higher in atopic patients than in the control group (30 vs...
September 21, 2017: Archives of Dermatological Research
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