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https://www.readbyqxmd.com/read/29035614/the-impact-and-implication-of-peripheral-vascular-leakage-on-ultra-widefield-fluorescein-angiography-in-uveitis
#1
Akshay S Thomas, Travis Redd, John P Campbell, Neal V Palejwala, Justin T Baynham, Eric B Suhler, James T Rosenbaum, Phoebe Lin
PURPOSE: To study if peripheral vascular leakage (PVL) on ultra-widefield fluorescein angiography (UWFFA) prognosticates complications of uveitis or necessitates treatment augmentation. METHODS: Retrospective cohort study of uveitis patients imaged with UWFFA and ≥1 yr of follow-up. RESULTS: We included 73 eyes of 42 patients with uveitis. There was no difference in baseline, intermediate, final visual acuity (p = 0.47-0.95) or rates of cystoid macular edema (CME) (p = 0...
October 16, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29024359/paravalvular-leak-closure-under-intracardiac-echocardiographic-guidance
#2
Neil Ruparelia, Jacob Cao, James D Newton, Neil Wilson, Matthew J Daniels, Oliver J Ormerod
OBJECTIVES: The objective of this study was to determine the safety and efficacy of intracardiac echocardiography (ICE) to guide percutaneous paravalvular leak (PVL) closure. BACKGROUND: PVL following surgical valve replacement occurs in 2%-15% of patients. Percutaneous treatment is an accepted management strategy in patients deemed to be too high risk for redo surgery. This is most commonly performed with transesophageal (TOE) guidance requiring general anesthesia that both potentially further increase the risk of intervention...
October 10, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29023054/genetic-characterization-antimicrobial-resistance-patterns-and-virulence-determinants-of-staphylococcus-aureus-isolated-form-bovine-mastitis
#3
Amal Awad, Hazem Ramadan, Sherif Nasr, Ahmed Ateya, Samar Atwa
BACKGROUND AND OBJECTIVE: Staphylococcus aureus is commonly associated with mastitis in dairy herds with potential public health implications. This study was conducted to investigate the existence of S. aureus in mastitic milk and to determine the antimicrobial resistance profiles of the isolated strains as well as the resistance and virulence associated genes. MATERIALS AND METHODS: Two hundred quarter milk samples were collected from 3 dairy farms at Dakahliya (n = 2) and Damietta (n = 1) Governorates, Egypt from September to December 2016...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/28986579/outcomes-of-23-and-24-weeks-gestation-infants-in-wellington-new-zealand-a-single-centre-experience
#4
Mary Judith Berry, Maria Saito-Benz, Clint Gray, Rebecca Maree Dyson, Paula Dellabarca, Stefan Ebmeier, David Foley, Dawn Elizabeth Elder, Vaughan Francis Richardson
Optimal perinatal care of infants born less than 24 weeks gestation remains contentious due to uncertainty about the long-term neurodevelopment of resuscitated infants. Our aim was to determine the short-term mortality and major morbidity outcomes from a cohort of inborn infants born at 23 and 24 weeks gestation and to assess if these parameters differed significantly between infants born at 23 vs. 24 weeks gestation. We report survival rates at 2-year follow-up of 22/38 (58%) at 23 weeks gestation and 36/60 (60%) at 24 weeks gestation...
October 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28982560/surgery-versus-transcatheter-interventions-for-significant-paravalvular%C3%A2-prosthetic-leaks
#5
Xavier Millán, Ismail Bouhout, Anna Nozza, Karla Samman, Louis-Mathieu Stevens, Yoan Lamarche, Antonio Serra, Anita W Asgar, Ismail El-Hamamsy, Raymond Cartier, Michel Pellerin, Stephane Noble, Phillipe Demers, Reda Ibrahim, E Marc Jolicœur, Denis Bouchard
OBJECTIVES: This study sought to assess the relative merit of surgical correction (SC) versus transcatheter reduction on long-term outcomes in patients with significant paravalvular leak (PVL) refractory to medical therapy. BACKGROUND: PVL is the most frequent dysfunction following prosthetic valve replacement. Although repeat surgery is the gold standard, transcatheter reduction (TR) of PVL has been associated with reduced mortality. METHODS: From 1994 to 2014, 231 patients underwent SC (n = 151) or TR (n = 80) PVL correction...
October 9, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28982558/transcatheter-and-surgical-management-of%C3%A2-mitral%C3%A2-paravalvular-leak-long-term-outcomes
#6
Mohamad Alkhouli, Charanjit S Rihal, Chad J Zack, Mackram F Eleid, Elad Maor, Mohammad Sarraf, Allison K Cabalka, Guy S Reeder, Donald J Hagler, Joseph F Maalouf, Vuyisile T Nkomo, Hartzell V Schaff, Sameh M Said
OBJECTIVES: The aim of this study was to report the use trends and immediate and long-term outcomes of a large cohort of patients who underwent redo surgery or transcatheter repair of paravalvular leaks (PVLs) at a tertiary referral center. BACKGROUND: Percutaneous treatment of mitral PVL has emerged as an alternative to surgical treatment in high-risk surgical candidates. There are limited data on the utilization trends, safety, and efficacy of both procedures in the management of mitral PVL...
October 9, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28968210/plant-derived-antimicrobial-peptide-ib-amp1-as-a-potential-alternative-drug-candidate-for-staphylococcus-aureus-toxins
#7
S Ojha, S Deep, S Kundu
Due to an increase in the occurrence of multi drug resistant microorganisms a need for the development of alternative drugs comes in light. This alternative drug should be such that the microorganisms should not be able to develop resistance against them easily. Antimicrobial peptides are the most potential candidates to be developed as alternative drug. In the present study the three toxins ETA, ETB and PVL of Staphylococcus aureus were docked with four antimicrobial peptides, Ib-AMP1, JCPep7, Snakin2, Sesquin, derived from plants...
July 31, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28961977/risk-of-hiv-transmission-during-combined-art-initiation-for-hiv-infected-persons-with-severe-immunosuppression
#8
V Supervie, L Assoumou, R Breban, F Lert, D Costagliola, G Pialoux, R Landman, P M Girard, L Slama
Background: Individuals presenting for care with severe immunosuppression typically have high plasma HIV viral load (pVL) and may transmit HIV before and after initiation of combination antiretroviral therapies (cART). Patients and methods: Using risk equations and data collected in the IMEA 040 DATA trial on sexual behaviour and pVL level of 84 HIV-infected patients (23 women), we estimated monthly rates of HIV transmission for each virologically unsuppressed participant (pVL >50 copies/mL) who reported sex with HIV-negative or unknown serostatus (HNUS) partners at cART initiation, 24 weeks (W24) and W48 after; rates were considered negligible for other participants...
August 14, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28960081/a-systematic-proteogenomic-approach-to-exploring-a-novel-function-for-nherf1-in-human-reproductive-disorder-lessons-for-exploring-missing-proteins
#9
Keun Na, Heon Shin, Jin-Young Cho, Sang Hee Jung, Jaeseung Lim, Jong-Sun Lim, Eun Ah Kim, Hye Sun Kim, Ah Reum Kang, Ji Hye Kim, Jeong Min Shin, Seul-Ki Jeong, Chae-Yeon Kim, Jun Young Park, Hyung-Min Chung, Gilbert S Omenn, William S Hancock, Young-Ki Paik
One of the major goals of the Chromosome-Centric Human Proteome Project (C-HPP) is to fill the knowledge gaps between human genomic information and the corresponding proteomic information. These gaps are due to "missing" proteins (MPs)-predicted proteins with insufficient evidence from mass spectrometry (MS), biochemical, structural or antibody analyses-that currently account for 2,579 of the 20,159 predicted human proteins (neXtProt, 2017-02). We address some of the lessons learned from the inconsistent annotations of missing proteins in databases (DB) and demonstrate a systematic proteogenomic approach designed to explore a potential new function of a known protein...
September 29, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28958473/expression-of-hypoxia-inducible-factor-1%C3%AE-and-its-correlation-with-phosphoenolpyruvate-carboxykinase-after-portal-vein-ligation-in-rats
#10
Changjun Jia, Hua Yang, Chaoliu Dai, Feng Xu, Songlin Peng, Yang Zhao, Chuang Zhao, Liang Zhao
AIMS: Portal vein ligation (PVL) has been used to effectively increase future liver remnant (FLR) in hepatectomy for treatment of liver cancer. However, the underlying molecular mechanisms have not been well characterized. The present study aimed to determine expression of hypoxia inducible factor-1alpha (HIF-1α) in response to PVL and assess the correlation of HIF-1α and phosphoenolpyruvate carboxykinase (PEPCK). MAIN METHODS: Male Sprague-Dawley rats underwent PVL and were sacrificed at different time points (12, 24, 48, 72, and 168h) after surgery...
September 26, 2017: Life Sciences
https://www.readbyqxmd.com/read/28956540/molecular-characteristics-and-antibiotic-resistance-pattern-of-staphylococcus-aureus-nasal-carriage-in-tertiary-care-hospitals-of-isfahan-iran
#11
Malihe Karimi, Bahram Nasr Esfahani, Mehrdad Halaji, Sina Mobasherizadeh, Mojtaba Shahin, Seyed Rohollah Havaei, Dariush Shokri, Seyed Asghar Havaei
Carriage of S. aureus in the anterior nares seems to play a significant role in the pathogenesis of infection. This study aimed to determine the molecular characteristics and antibiotic susceptibility pattern of S. aureus isolates obtained from the nasal carriage of health care workers (HCWs). This study was performed during July 2014 to July 2015 at three tertiary care hospitals. Nasal samples were collected from the nasal cavity of HCWs. Standard microbiological methods were used for identification of S. aureus isolates...
September 1, 2017: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/28956538/epidemiology-of-panton-valentine-leukocidin-harbouring-staphylococcus-aureus-in-cutaneous-infections-from-iran-a-systematic-review-and-meta-analysis
#12
Milad Shahini Shams Abadi, Iraj Nikokar, Seyedeh Mahsan Hoseini Alfatemi, Yalda Malekzadegan, Abdolah Azizi, Hadi Sedigh Ebrahim-Saraie
Panton-Valentine Leukocidin (PVL) producing Staphylococcus aureus has been associated with severity of skin infections and pathology that suggest a major role in pathogenicity. The present study aimed to determine the overall prevalence of PVL harbouring S. aureus isolates from cutaneous infections in Iran. A systematic search was performed by using Medline electronic databases (PubMed) from the papers published by Iranian authors to the end of March 2017. Ten publications which met our inclusion criteria were then selected for data extraction and analysis by Comprehensive Meta-Analysis Software...
September 1, 2017: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/28950994/the-clinical-significance-of-perivalvular-pannus-in-prosthetic-mitral-valves-can-cardiac-ct-be-helpful
#13
Suyon Chang, Young Joo Suh, Kyunghwa Han, Jin Young Kim, Young Jin Kim, Byung-Chul Chang, Byoung Wook Choi
BACKGROUND: The clinical significance of pannus in the prosthetic mitral valve (MV) is not well documented. OBJECTIVES: To investigate the clinical significance of pannus on cardiac computed tomography (CT) in patients with a prosthetic MV. METHODS: A total of 130 patients with previous MV replacement who underwent cardiac CT were retrospectively included in this study. The presence of pannus, paravalvular leak (PVL) around the prosthetic MV and limitation of motion (LOM) of the MV were analyzed using CT...
September 21, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28946704/emergence-of-nasal-carriage-of-st80-and-st152-pvl-staphylococcus-aureus-isolates-from-livestock-in-algeria
#14
Amir Agabou, Zouleikha Ouchenane, Christelle Ngba Essebe, Salim Khemissi, Mohamed Tedj Eddine Chehboub, Ilyes Bey Chehboub, Albert Sotto, Catherine Dunyach-Remy, Jean-Philippe Lavigne
The spread of toxinogenic Staphylococcus aureus is a public health problem in Africa. The objectives of the study were to investigate the rate of S. aureus nasal carriage and molecular characteristics of these strains in livestock and humans in three Algerian provinces. Nasal samples were collected from camels, horses, cattle, sheep and monkeys, as well as humans in contact with them. S. aureus isolates were genotyped using DNA microarray. The rate of S. aureus nasal carriage varied between species: camels (53%), humans and monkeys (50%), sheep (44...
September 25, 2017: Toxins
https://www.readbyqxmd.com/read/28941908/prevalence-of-staphylococcus-aureus-and-of-methicillin-resistant-s-%C3%A2-aureus-mrsa-along-the-production-chain-of-dairy-products-in-north-western-greece
#15
Panagiotis Papadopoulos, Theofilos Papadopoulos, Apostolos S Angelidis, Evridiki Boukouvala, Antonios Zdragas, Anna Papa, Christos Hadjichristodoulou, Daniel Sergelidis
The objective of this study was to estimate the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in the production chain of dairy products. Of 367 tested samples (36 bulk tank milk (BTM), 19 dairy products, 72 human, 185 animal, 55 equipment), 212 (57.8%) were found positive for S. aureus. Almost all isolates (99.6%) were resistant to at least one antimicrobial and 13.3% were multi-drug resistant (MDR), exhibiting resistance to three or more antibiotic classes. Eleven samples (3%) were found contaminated by MRSA carrying the mecA gene...
February 2018: Food Microbiology
https://www.readbyqxmd.com/read/28941388/high-frequency-of-s-aureus-mssa-mrsa-in-children-under-1-year-old-with-skin-and-soft-tissue-infections
#16
Lorena Salazar, Judy Natalia Jimenez Quiceno
OBJECTIVE: Staphylococcus aureus is responsible for a large number of infections in pediatric population; however, information about the behavior of such infections in this population is limited. The aim of the study was to describe the clinical, epidemiological, and molecular characteristics of infections caused by methicillin-susceptible and resistant S. aureus (MSSA-MRSA) in a pediatric population. METHOD: A cross-sectional descriptive study in patients from birth to 14 years of age from three high-complexity institutions was conducted (2008-2010)...
September 20, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28941127/a-comparison-of-the-fully-repositionable-and-retrievable-boston-lotus-and-direct-flow-medical-valves-for-the-treatment-of-severe-aortic-stenosis-a-single-center-experience
#17
Francesco Giannini, Azeem Latib, Matteo Montorfano, Neil Ruparelia, Vittorio Romano, Matteo Longoni, Luca Ferri, Richard Jabbour, Antonio Mangieri, Damiano Regazzoli, Marco Ancona, Nicola Buzzatti, Lorenzo Azzalini, Akihito Tanaka, Eustachio Agricola, Alaide Chieffo, Ottavio Alfieri, Antonio Colombo
BACKGROUND: Second generation transcatheter aortic valve implantation (TAVI) devices have been designed to reduce the rate of paravalvular leak (PVL) and other complications. An important technological advancement has been the ability to fully reposition devices to facilitate optimal implantation depth and position to reduce the likelihood of PVL. OBJECTIVES: To compare procedural and 30-day outcomes according to the Valve Academic Research Consortium (VARC)-2 criteria following TAVI with the fully repositionable and retrievable Lotus and DFM devices...
September 20, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28937991/sociodemographic-correlates-of-hiv-drug-resistance-and-access-to-drug-resistance-testing-in-british-columbia-canada
#18
Genevieve Rocheleau, Conrado Franco-Villalobos, Natalia Oliveira, Zabrina L Brumme, Melanie Rusch, Jeannie Shoveller, Chanson J Brumme, P Richard Harrigan
Sociodemographic correlates of engagement in human immunodeficiency virus (HIV) care are well studied, however the association with accessing drug resistance testing (DRT) and the development of drug resistance have not been characterized. Between 1996-2014, 11 801 HIV patients accessing therapy in British Columbia were observed longitudinally. A subset of 9456 patients had testable viral load; of these 8398 were linked to census data. Sociodemographic (census tract-level) and clinical (individual-level) correlates of DRT were assessed using multivariable General Estimating Equation logistic regression adjusted odds ratios (aOR)...
2017: PloS One
https://www.readbyqxmd.com/read/28935328/valve-in-valve-transcatheter-aortic-valve-implantation-a-novel-approach-to-treat-paravalvular-leak
#19
Pranav Loyalka, Kelsey B Montgomery, Tom C Nguyen, Richard W Smalling, Melissa Howe, Keshava Rajagopal
Enlarging or "cracking" a surgical stented bioprosthetic valve during valve-in-valve transcatheter aortic valve implantation (TAVI) increases orifice area, reducing transvalvular energy losses. We demonstrate that TAVI with valve cracking can be used to treat paravalvular leak (PVL) while providing optimal aortic valve physiology. A 61-year-old woman with a history of aortic valve replacement with a stented bioprosthesis presented with heart failure. Transthoracic echocardiography revealed severe prosthetic aortic valve stenosis with PVL and severe regurgitation...
October 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28934915/significant-intraventricular-hemorrhage-is-more-likely-in-very-preterm-infants-born-by-vaginal-delivery-a-multi-centre-retrospective-cohort-study
#20
Islam Gamaleldin, David Harding, Dimitrios Siassakos, Tim Draycott, David Odd
OBJECTIVES: The objective of this study is to determine the association between mode of delivery (vaginal delivery [VD] versus cesarean section [CS]) and the rate of significant intraventricular hemorrhage (sIVH) in preterm infants. METHODS: A multicenter retrospective cohort study, based on data collected from the Vermont Oxford Network database. Infants born between 23 and 31(+6) weeks of gestational age between 2001 and 2014 were identified. Exposure was the mode of birth (VD versus CS)...
October 10, 2017: Journal of Maternal-fetal & Neonatal Medicine
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