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https://www.readbyqxmd.com/read/29454049/emergence-of-vancomycin-intermediate-and-resistant-staphylococcus-aureus-among-methicillin-resistant-s-aureus-isolated-from-clinical-specimens-in-the-northwest-of-iran
#1
Maryam Ghahremani, Nima Hosseini Jazani, Yaeghob Sharifi
OBJECTIVES: This study aimed to evaluate the frequency, the, phenotypic and molecular characteristics of methicillin- resistant, Staphylococcus aureus (MRSA) and vancomycin-resistant S. aureus (VRSA), from clinical specimens at three university teaching hospitals in Urmia-North West of Iran (2012- 2015). METHODS: After identification of the isolates, the antibiotic, susceptibility, the presence of mecA, vanA, pvl genes and staphylococcal, cassette chromosome mec (SCCmec) typing were evaluated...
February 14, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29450768/cc398-staphylococcus-aureus-subpopulations-in-belgian-patients
#2
M Angeles Argudín, A Deplano, S Vandendriessche, M Dodémont, C Nonhoff, O Denis, S Roisin
Studies based on genome-wide single nucleotide polymorphisms (SNPs) supported the existence of two subpopulations in clonal complex (CC) 398 Staphylococcus aureus: an ancestral human-adapted clade (HC) and an animal-associated clade (AC). In this study, we have investigated the occurrence of genetic markers that allow discrimination of these subpopulations among CC398 isolates collected during 2014 to 2016 from human patients in Belgium. A collection of isolates was investigated by means of spa-typing and 16S-mecA-nuc PCR...
February 15, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29440661/panton-valentine-leukocidin-colocalizes-with-retinal-ganglion-and-amacrine-cells-and-activates-glial-reactions-and-microglial-apoptosis
#3
XuanLi Liu, Pauline Heitz, Michel Roux, Daniel Keller, Tristan Bourcier, Arnaud Sauer, Gilles Prévost, David Gaucher
Experimental models have established Panton-Valentine leukocidin (PVL) as a potential critical virulence factor during Staphylococcus aureus endophthalmitis. In the present study, we aimed to identify retinal cell targets for PVL and to analyze early retinal changes during infection. After the intravitreous injection of PVL, adult rabbits were euthanized at different time points (30 min, 1, 2, 4 and 8 h). PVL location in the retina, expression of its binding receptor C5a receptor (C5aR), and changes in Müller and microglial cells were analyzed using immunohistochemistry, Western blotting and RT-qPCR...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29439661/genome-wide-scan-for-commons-snps-affecting-bovine-leukemia-virus-infection-level-in-dairy-cattle
#4
Hugo A Carignano, Dana L Roldan, María J Beribe, María A Raschia, Ariel Amadio, Juan P Nani, Gerónimo Gutierrez, Irene Alvarez, Karina Trono, Mario A Poli, Marcos M Miretti
BACKGROUND: Bovine leukemia virus (BLV) infection is omnipresent in dairy herds causing direct economic losses due to trade restrictions and lymphosarcoma-related deaths. Milk production drops and increase in the culling rate are also relevant and usually neglected. The BLV provirus persists throughout a lifetime and an inter-individual variation is observed in the level of infection (LI) in vivo. High LI is strongly correlated with disease progression and BLV transmission among herd mates...
February 13, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29436652/neuronalinjury-and-roles-of-apoptosis-and-autophagy-in-a-neonatal-rat-model-of-hypoxia-ischemia-induced-periventricular-leukomalacia
#5
Lin Qiao, Jianhua Fu, Xindong Xue, Yongyan Shi, Li Yao, Wanjie Huang, Jun Li, Dan Zhang, Na Liu, Xin Tong, Yanna Du, Yuqing Pan
As research into periventricular leukomalacia (PVL) gradually increases, concerns are emerging about long‑term neuron injury. The present study aimed to investigate neuronal injury and the relevant alterations in apoptosis and autophagy in a PVL model established previously. A rat model of hypoxia‑ischemia‑induced PVL was established. In the model group, Sprague‑Dawley (SD) rats [postnatal day 3 (P3)] were subjected to right common carotid artery ligation followed by suturing and exposed to 6‑8% oxygen for 2 h; in the control group, SD rats (P3) were subjected to right common carotid artery dissection followed by suturing, without ligation and hypoxic exposure...
February 7, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29433876/autogenous-hepatic-tissue-transplantation-into-the-omentum-in-a-novel-ectopic-liver-regeneration-murine-model
#6
Francisco Igor Macedo, Joseph J Eid, Milessa Decker, Barry Herschman, Edsa Negussie, Vijay K Mittal
BACKGROUND: Liver regeneration involves hyperplasia and hypertrophy of hepatic cells. The capacity of macroscopic liver tissue to regenerate in ectopic sites is unknown. We aim to develop a novel in vivo model of ectopic liver survivability and regeneration and assess its functionality. METHODS: Adult male Sprague-Dawley rats (n = 23) were divided into four groups: (1) single-stage (SS) group, wedge liver resection was performed, and the parenchyma was directly implanted into the omentum; (2) double-stage (DS) group, omentum pedicle was transposed over the left hepatic lobe followed by wedge liver resection along with omental flap; (3) Biogel + DS group, rats received intraperitoneal injection of inert polymer particles prior to DS; (4) Biogel + DS + portal vein ligation (PVL) group, Biogel + DS rats underwent subsequent PVL...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29433315/factors-controlling-drug-release-in-cross-linked-poly-valerolactone-based-matrices
#7
Frantz Le Devedec, Hilary Boucher, David N Dubins, Christine Allen
There is keen interest in the development of biocompatible and biodegradable implantable delivery systems (IDDS) that provide sustained drug release for prolonged periods in humans. These systems have the potential to enhance therapeutic outcomes, reduce systemic toxicity and improve patient compliance. Herein, we report the preparation and physico-chemical characterization of cross-linked polymeric matrices from poly(valerolactone)-co-poly(allyl-δ-valerolactone) (PVL-co-PAVL) copolymers for use in drug delivery...
February 13, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29427033/a-retrospective-20-year-analysis-of-proliferative-verrucous-leukoplakia-and-its-progression-to-malignancy-and-association-with-high-risk-human-papillomavirus
#8
Jasbir D Upadhyaya, Sarah G Fitzpatrick, Mohammed N Islam, Indraneel Bhattacharyya, Donald M Cohen
Proliferative verrucous leukoplakia (PVL) is defined as an aggressive, relentless and recalcitrant form of leukoplakia that has a high propensity for malignant transformation. The aim of this study was to evaluate the malignant potential of PVL and determine its possible association with high-risk human papillomavirus (HPV). Twenty cases with a clinical and biopsy proven diagnosis of PVL were collected from the University of Florida Oral Medicine clinic database. Immunohistochemistry was performed to evaluate the expression of p16INK4A and p53 genes in the PVL lesions...
February 9, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29425829/assessment-and-optimization-of-liver-volume-before-major-hepatic-resection-current-guidelines-and-a-narrative-review
#9
REVIEW
Adeel S Khan, Sandra Garcia-Aroz, Mohammad A Ansari, Syed M Atiq, Michael Senter-Zapata, Kathryn Fowler, M B Doyle, W C Chapman
Post hepatectomy liver failure (PHLF) remains a significant cause of morbidity and mortality after major liver resection. Although the etiology of PHLF is multifactorial, an inadequate functional liver remnant (FLR) is felt to be the most important modifiable predictor of PHLF. Pre-operative evaluation of FLR function and volume is of paramount importance before proceeding with any major liver resection. Patients with inadequate or borderline FLR volume must be considered for volume optimization strategies such as portal vein embolization (PVE), two stage hepatectomy with portal vein ligation (PVL), Yttrium-90 radioembolization, and associating liver partition and portal vein ligation for staged hepatectomy (ALPPS)...
February 6, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29409694/effective-concentration-of-intravenous-immunoglobulin-for-neutralizing-panton-valentine-leukocidin-in-human-blood
#10
Jun Tanaka, Fumihiro Hirayama, Sayuri Yanase, Shusei Uno, Takashi Nakae, Akihito Kamizono, Hideaki Hanaki
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infects healthy individuals, although the precise cause remains unclear. CA-MRSA produces Panton-Valentine leukocidin (PVL), which often causes severe invasive infection; however, antitoxin drugs against PVL are limited. Intravenous immunoglobulin (IVIg) possesses antitoxin activity, but unfortunately, the optimal dose is unknown. Here, we measured the PVL neutralizing antibody titer in the plasma of Japanese individuals and sera of American donors...
February 3, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29397175/short-communication-characterization-of-staphylococcus-aureus-isolated-along-the-raw-milk-cheese-production-process-in-artisan-dairies-in-italy
#11
S Johler, G Macori, A Bellio, P L Acutis, S Gallina, L Decastelli
Staphylococcus aureus is a common cause of food-borne intoxications. Several staphylococcal food poisoning outbreaks have been linked to consumption of raw milk cheeses and artisanal cheese production. However, information on Staph. aureus isolated from artisanal raw milk cheeses and small-scale dairy production environments is very limited. Therefore, we aimed to characterize Staph. aureus isolated along the artisanal raw milk production chain by determining (1) the population structure, and (2) the presence/absence of enterotoxin genes, mecA/C, and pvl...
January 31, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29391581/panton-valentine-leukocidin-associated-with-s-aureus-osteomyelitis-activates-platelets-via-neutrophil-secretion-products
#12
Silke Niemann, Anne Bertling, Martin F Brodde, Anke C Fender, Hélène Van de Vyver, Muzaffar Hussain, Dirk Holzinger, Dirk Reinhardt, Georg Peters, Christine Heilmann, Bettina Löffler, Beate E Kehrel
Globalization and migration promote the spread of Panton-Valentine leukocidin (PVL)-positive Staphylococcus aureus strains. The toxin PVL is linked to the development of thrombosis in association with osteomyelitis. The mechanisms by which PVL drives thrombosis development are however still unknown. We demonstrate that PVL-damaged neutrophils activate platelets via neutrophil secretion products, such as α-defensins and the myeloperoxidase product HOCl, as well as the formation of HOCl-modified proteins. Neutrophil damage by PVL is blocked by anti-PVL-antibodies, explaining why especially young osteomyelitis patients with a low antibody titre against PVL suffer from thrombotic complications...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29386909/distribution-of-sasx-pvl-and-qaca-b-genes-in-epidemic-methicillin-resistant-staphylococcus-aureus-strains-isolated-from-east-china
#13
Haishen Kong, Lingmei Fang, Rujin Jiang, Jixiang Tong
Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a major nosocomial pathogen. Various virulence and antiseptic-resistant factors increase the pathogenicity of MRSA strains and allow for increased infection rates. Purpose: The purpose of this study was to investigate the prevalence and distribution of virulence-associated and antiseptic-resistant genes from epidemic MRSA strains isolated from East China. Methods: A newly designed multiplex PCR assay was used to assess whether the virulence-associated genes sasX and pvl and the chlorhexidine tolerance gene qacA/B were present in 189 clinical isolates of MRSA...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29371627/volume-size-professionals-specialization-and-nutrition-management-of-nicus-and-their-association-with-treatment-quality-in-vlbw-infants
#14
Felix Miedaner, Kristina Langhammer, Christian Enke, Wolfgang Göpel, Angela Kribs, Anika Nitzsche, Rainer Riedel, Christiane Woopen, Ludwig Kuntz, Bernhard Roth
OBJECTIVE: To assess the association of volume, size, the availability of highly-specialized professionals and nutrition management of NICUs with treatment quality among VLBW infants. STUDY DESIGN: A prospective multicenter study of 923 VLBW infants in 66 German NICUs, born between May and October 2013. Using multilevel modeling, we examined the association between the aforementioned organizational characteristics and treatment quality, measured via major morbidities (severe IVH, PVL, BPD, NEC, FIP, ROP, and discharge without severe complications) and medical process measures of VLBW infants...
January 25, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29359388/three-dimensional-prototyping-for-procedural-simulation-of-transcatheter-mitral-valve-replacement-in-patients-with-mitral-annular-calcification
#15
Abdallah El Sabbagh, Mackram F Eleid, Jane M Matsumoto, Nandan S Anavekar, Mohammed A Al-Hijji, Sameh M Said, Vuyisile T Nkomo, David R Holmes, Charanjit S Rihal, Thomas A Foley
INTRODUCTION: Three-dimensional (3D) prototyping is a novel technology which can be used to plan and guide complex procedures such as transcatheter mitral valve replacement (TMVR). METHODS: Eight patients with severe mitral annular calcification (MAC) underwent TMVR. 3D digital models with digital balloon expandable valves were created from pre-procedure CT scans using dedicated software. Five models were printed. These models were used to assess prosthesis sizing, anchoring, expansion, paravalvular gaps, left ventricular outflow tract (LVOT) obstruction, and other potential procedure pitfalls...
January 23, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29348006/importance-of-contrast-aortography-with%C3%A2-lotus-transcatheter-aortic-valve-replacement-a-post-hoc-analysis-from-the-respond-post-market-study
#16
Lennart van Gils, Jochen Wöhrle, David Hildick-Smith, Sabine Bleiziffer, Daniel J Blackman, Mohamed Abdel-Wahab, Ulrich Gerckens, Stephen Brecker, Vinayak Bapat, Thomas Modine, Osama I Soliman, Andrey Nersesov, Dominic Allocco, Volkmar Falk, Nicolas M Van Mieghem
OBJECTIVES: The aim of this post hoc analysis from the RESPOND (Repositionable Lotus Valve System-Post-Market Evaluation of Real World Clinical Outcomes) post-market study was to assess the final implantation depth on the contrast aortogram after Lotus valve (Boston Scientific, Marlborough, Massachusetts) transcatheter aortic valve replacement (TAVR) and to correlate with permanent pacemaker implantation (PPI) and paravalvular leak (PVL). BACKGROUND: Contrast aortography allows for the assessment of implantation depth and PVL during and after TAVR...
January 22, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29337414/proliferative-leukoplakia-proposed-new-clinical-diagnostic-criteria
#17
Alessandro Villa, Reshma S Menon, Alexander R Kerr, Fabio De Abreu Alves, Andres Guollo, David Ojeda, Sook B Woo
OBJECTIVE: We aimed to characterize proliferative verrucous leukoplakia (PVL) from a clinical and histopathologic standpoint and suggest an updated classification. SUBJECTS AND METHODS: Records of patients seen at three oral medicine centers with a clinical diagnosis of PVL were reviewed for clinical and histopathologic features, and malignant transformation (MT). RESULTS: There were 42 patients (median age: 69 years [range:36-88]; 35 females)...
January 16, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29337004/quantitative-sensory-testing-profiles-in-children-adolescents-and-young-adults-6-20-years-with-cerebral-palsy-hints-for-a-neuropathic-genesis-of-pain-syndromes
#18
M Blankenburg, J Junker, G Hirschfeld, E Michel, F Aksu, J Wager, B Zernikow
INTRODUCTION: Many patients with cerebral palsy (CP) suffer chronic pain as one of the most limiting factors in their quality of life. In CP patients, pain mechanisms are not well understood, and pain therapy remains a challenge. Quantitative sensory testing (QST) might provide unique information about the functional status of the somatosensory system and therefore better guide pain treatment. OBJECTIVES: To understand better the underlying pain mechanisms in pediatric CP patients, we aimed to assess clinical and pain parameters, as well as QST profiles, which were matched to the patients' cerebral imaging pathology...
December 30, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29336909/-non-reported-spa-types-in-our-country-in-staphylococcus-aureus-from-adult-patients-of-a-school-hospital-santa-fe-argentina
#19
Carla Tomatis, María R Baroni, María A Mendosa, Alicia Nagel, Analia Mollerach, Claudia Alvarez, Maria Laura Zurbriggen, Sabrina Cristobal, Glenda Segovia, Emilce de Los A Méndez
Staphylococcus aureus is a pathogen associated a different kind of infection. Molecular markers are useful tools to study microbial epidemiology. Twenty two methicillin-resistant S. aureus (MRSA) and 23 methicillin-susceptible S. aureus (MSSA) were studied by mecA gene, SCCmec cassette, Panton Valentine leucocidin (PVL) and spa polymorphism. The clinical data patients were analyzed. MSSA was prevalent in samples different from skin and soft tissue (SST) and in hospitalized patients, whereas MRSA in SST. SCCmec type IV was predominant, followed by type I...
January 11, 2018: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/29330899/retrograde-transmitral-paravalvular-leak-closure-through-an-antegrade-transseptal-approach-a-novel-technique
#20
Roberto J Cubeddu, Hector J Crespo, Gian M Novaro
Mitral paravalvular leak (PVL) remains a well-known complication after mitral valve replacement. Since the first report over 25 years ago, several catheter-based PVL closure techniques have been described. Most of these comprise of either an antegrade transseptal approach, or a retrograde transaortic or transapical approach. We herein report a novel percutaneous mitral PVL closure technique that was safely and successfully performed after failed attempt using a conventional antegrade approach.
January 13, 2018: Catheterization and Cardiovascular Interventions
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