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https://www.readbyqxmd.com/read/29667040/management-of-superficial-and-deep-seated-staphylococcus-aureus-skin-and-soft-tissue-infections-in-sub-saharan-africa-a-post-hoc-analysis-of-the-staphnet-cohort
#1
Abraham Alabi, Theckla Kazimoto, Marthe Lebughe, Delfino Vubil, Patrick Phaku, Inacio Mandomando, Winfried V Kern, Salim Abdulla, Alexander Mellmann, Lena Peitzmann, Markus Bischoff, Georg Peters, Mathias Herrmann, Martin P Grobusch, Frieder Schaumburg, Siegbert Rieg
PURPOSE: The incidence of Staphylococcus aureus skin and soft tissue infection (SSTI) is high in sub-Saharan Africa. This is fueled by a high prevalence of Panton-Valentine leukocidin (PVL), which can be associated with necrotizing disease. The aim was to describe the clinical presentation and the treatment of SSTI in the African setting and to identify challenges in the management. METHODS: Patients (n = 319) were recruited in DR Congo (n = 56, 17.6%), Gabon (n = 89, 27...
April 17, 2018: Infection
https://www.readbyqxmd.com/read/29664051/predictive-value-of-cranial-ultrasound-for-neurodevelopmental-outcomes-of-very-preterm-infants-with-brain-injury
#2
Xue-Hua Zhang, Shi-Jun Qiu, Wen-Juan Chen, Xi-Rong Gao, Ya Li, Jing Cao, Jing-Jing Zhang
Background: Compared with full-term infants, very preterm infants are more vulnerable to injury and long-term disability and are at high risk of death. The predictive value of ultrasound and imaging on the neurodevelopment is one of the hot topics. This study aimed to investigate the relationship between cranial ultrasound (cUS) variables and neurodevelopmental outcomes of very preterm infants. Methods: Totally 129 very preterm infants (gestational age ≤28 weeks) in neonatal intensive care unit of Hunan Children's Hospital between January 2012 and November 2014 were included in this retrospective study...
April 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29663518/potentially-malignant-disorders-revisited-the-lichenoid-lesion-proliferative-verrucous-leukoplakia-conundrum
#3
P J Thomson, M L Goodson, D R Smith
BACKGROUND: Clinically identifiable potentially malignant disorders (PMD) precede oral squamous cell carcinoma development. Oral lichenoid lesions (OLL) and proliferative verrucous leukoplakia (PVL) are specific precursor lesions believed to exhibit both treatment resistance and a high risk of malignant transformation (MT). METHODS: A retrospective review of 590 PMD patients treated in Northern England by CO2 laser surgery between 1996 and 2014 was carried out. Lesions exhibiting lichenoid or proliferative verrucous features were identified from the patient database and their clinico-pathological features and outcome post-treatment determined at the study census date of 31 December 2014...
April 16, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29662467/multilocus-sequence-typing-and-virulence-associated-gene-profile-analysis-of-staphylococcus-aureus-isolates-from-retail-ready-to-eat-food-in-china
#4
Xiaojuan Yang, Shubo Yu, Qingping Wu, Jumei Zhang, Shi Wu, Dongli Rong
The aim of this study was to characterize the subtypes and virulence profiles of 69 Staphylococcus aureus isolates obtained from retail ready-to-eat food in China. The isolates were analyzed using multilocus sequence typing (MLST) and polymerase chain reaction (PCR) analysis of important virulence factor genes, including the staphylococcal enterotoxin (SE) genes ( sea , seb , sec , sed , see , seg , seh , sei , sej ), the exfoliative toxin genes ( eta and etb ), the toxic shock syndrome toxin-1 gene ( tst ), and the Panton-Valentine leucocidin-encoding gene ( pvl )...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29657423/prevalence-and-characterization-of-panton-valentine-leukocidin-positive-staphylococcus-aureus-in-bovine-milk-in-jabalpur-district-of-madhya-pradesh-india
#5
Neeraj Shrivastava, Varsha Sharma, Arpita Shrivastav, Anju Nayak, Ajay Kumar Rai
Aim: The study aimed to investigate the Panton-Valentine leukocidin (PVL)-positive Staphylococcus aureus in bovine milk due to its public health significance. Materials and Methods: A total of 400 milk samples of bovines taken from different dairy farms and outlets of Jabalpur were screened for the S. aureus and methicillin-resistant S. aureus (MRSA). The strains were tested for the PVL gene and antimicrobial sensitivity toward 10 different classes of antimicrobial agents...
March 2018: Veterinary World
https://www.readbyqxmd.com/read/29621629/genetic-characterization-of-staphylococcus-aureus-isolated-from-milk-and-nasal-samples-of-healthy-cows-in-tunisia-first-report-of-st97-t267-agri-sccmecv-mrsa-of-bovine-origin-in-tunisia
#6
Monia Khemiri, Mohamed Salah Abbassi, Natacha Couto, Riadh Mansouri, Salah Hammami, Constança Pomba
OBJECTIVES: This study aimed to screen for and characterize methicillin-susceptible S. aureus (MSSA) and MRSA in nasal swabs and milk from healthy cows from different regions in Tunisia. METHODS: One hundred and forty-one Staphylococcus spp. isolates were recovered from milk and nasal swabs of cows. S. aureus isolates were further characterized by determining their antibiotic susceptibilities, genes encoding antibiotic resistance and virulence factors, biofilm production, agr type and PFGE...
April 2, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29618431/investigation-of-staphylococcus-aureus-prevailing-in-the-environment-of-khyber-teaching-hospital-peshawar-pakistan
#7
Farmanullah Khan, Bashir Ahmad, Jawad Ahmed, Han Sang Yoo, Shumaila Bashir
The hospital environment plays an important role in the spread of microorganisms, including multi drug resistant (MDR) strains. Patients can acquire Methicillin-Resistant Staphylococcus aureus (MRSA) which can reside in the clinical setup that are not cleaned and can spread through air droplets, bed clothing, and healthcare workers. The purpose of this study was to investigate the prevalence of S. aureus in the Khyber Teaching Hospital (KTH). A total of 200 samples were collected from the floor, walls, air and inanimate objects in different wards of the KTH, during May 2012 to September 2012...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29616014/routine-whole-genome-sequencing-for-outbreak-investigations-of-staphylococcus-aureus-in-a-national-reference-center
#8
Geraldine Durand, Fabien Javerliat, Michèle Bes, Jean-Baptiste Veyrieras, Ghislaine Guigon, Nathalie Mugnier, Stéphane Schicklin, Gaël Kaneko, Emmanuelle Santiago-Allexant, Coralie Bouchiat, Patrícia Martins-Simões, Frederic Laurent, Alex Van Belkum, François Vandenesch, Anne Tristan
The French National Reference Center for Staphylococci currently uses DNA arrays and spa typing for the initial epidemiological characterization of Staphylococcus aureus strains. We here describe the use of whole-genome sequencing (WGS) to investigate retrospectively four distinct and virulent S. aureus lineages [clonal complexes (CCs): CC1, CC5, CC8, CC30] involved in hospital and community outbreaks or sporadic infections in France. We used a WGS bioinformatics pipeline based on de novo assembly (reference-free approach), single nucleotide polymorphism analysis, and on the inclusion of epidemiological markers...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29615958/lymphocytes-contribute-to-the-pathophysiology-of-neonatal-brain-injury
#9
Arshed Nazmi, Anna-Maj Albertsson, Eridan Rocha-Ferreira, Xiaoli Zhang, Regina Vontell, Aura Zelco, Mary Rutherford, Changlian Zhu, Gisela Nilsson, Carina Mallard, Henrik Hagberg, Jacqueline C Y Lai, Jianmei W Leavenworth, Xiaoyang Wang
Background: Periventricular leukomalacia (PVL) is the most common form of preterm brain injury affecting the cerebral white matter. This type of injury involves a multiphase process and is induced by many factors, including hypoxia-ischemia (HI) and infection. Previous studies have suggested that lymphocytes play a significant role in the pathogenesis of brain injury, and the aim of this study was to determine the contribution of lymphocyte subsets to preterm brain injury. Methods: Immunohistochemistry on brain sections from neonatal mice was performed to evaluate the extent of brain injury in wild-type and T cell and B cell-deficient neonatal mice ( Rag1 -/- mice) using a mouse model of HI-induced preterm brain injury...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29610444/hemodynamic-effects-of-valve-asymmetry-in-sapien-3-transcatheter-aortic-valves
#10
Daniel R Mangels, Mary Siki, Rohan Menon, Joseph Bavaria, Saif Anwaruddin, Jay Giri, Nimesh Desai, Wilson Y Szeto, Prashanth Vallabhajosyula, Howard C Herrmann
BACKGROUND: Eccentric valve deployment after transcatheter aortic valve replacement (TAVR) has been associated with abnormal leaflet shear stresses that may accelerate structural valve deterioration (SVD). This phenomenon has not been studied in patients receiving Sapien 3 prostheses (Edwards Lifesciences). METHODS: A retrospective cohort analysis of 100 patients who received Sapien 3 valves between 2013 and 2015 at a single institution was performed. Axial fluoroscopic images from the co-planar view were used to assess TAVR asymmetry, which was defined as a ratio of left-to-right valve heights ≤0...
April 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29599675/activity-of-antimicrobial-peptides-and-conventional-antibiotics-against-superantigen-positive-staphylococcus-aureus-isolated-from-patients-with-atopic-dermatitis
#11
Izabela Błażewicz, Maciej Jaśkiewicz, Lidia Piechowicz, Damian Neubauer, Roman J Nowicki, Wojciech Kamysz, Wioletta Barańska-Rybak
Introduction: Staphylococcus aureus causes a diverse array of diseases, ranging from relatively harmless localized skin infections to life-threatening systemic conditions. It secretes toxins directly associated with particular disease symptoms. Aim: To determine the prevalence of methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) colonization among patients with atopic dermatitis and to assess the antimicrobial susceptibility to conventional antibiotics and selected antimicrobial peptides among toxin-producing strains and nonproducing strains...
February 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29593659/how-to-control-htlv-1-associated-diseases-preventing-de-novo-cellular-infection-using-antiviral-therapy
#12
Amandine Pasquier, Sandrine Alais, Loic Roux, Maria-Isabel Thoulouze, Karine Alvarez, Chloé Journo, Hélène Dutartre, Renaud Mahieux
Five to ten million individuals are infected by Human T-cell Leukemia Virus type 1 (HTLV-1). HTLV-1 is transmitted through prolonged breast-feeding, by sexual contacts and by transmission of infected T lymphocytes through blood transfusion. One to ten percent of infected carriers will develop a severe HTLV-1-associated disease: Adult-T-cell leukemia/lymphoma (ATLL), or a neurological disorder named Tropical Spastic Paraparesis/HTLV-1 Associated Myelopathy (TSP/HAM). In vivo , HTLV-1 is mostly detected in CD4+ T-cells, and to a lesser extent in CD8+ T cells and dendritic cells...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29590335/first-line-raltegravir-emtricitabine-tenofovir-combination-in-hiv-2-infection-phase-2-non-comparative-trial-anrs-159-hiv-2
#13
Sophie Matheron, Diane Descamps, Sebastien Gallien, Amel Besseghir, Pierre Sellier, Laurent Blum, Emmanuel Mortier, Charlotte Charpentier, Roland Tubiana, Florence Damond, Gilles Peytavin, Diane Ponscarme, Fideline Collin, Francoise Brun-Vezinet, Genevieve Chene
Background: New options for first-line treatment of HIV-2 infection are needed. We evaluated an integrase inhibitor (raltegravir)-containing regimen. Methods: ART-naïve adults infected with HIV-2 only and history of CDC group B or C event, or a CD4 count <500 cells/μL, or a CD4 decrease >50 cells/μL/year over the past 3 years, or a confirmed plasma HIV-2 RNA (pVL) ≥100 copies (cp)/mL were eligible for this non-comparative trial. The composite primary endpoint was survival at 48 weeks (W48) without any of the following: CD4 gain from baseline <100 cells/μL, confirmed pVL ≥40 cp/mL from W24, raltegravir permanent discontinuation, incident B or C event...
March 24, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29589290/htlv-1-proviral-load-in-cerebrospinal-fluid-may-not-be-a-good-marker-to-differentiate-asymptomatic-carriers-with-high-proviral-load-in-blood-from-ham-tsp-patients
#14
Marina Lobato Martins, Anna Bárbara de Freitas Carneiro-Proietti, Rodrigo Nicolato, Débora Marques de Miranda, Luiz Cláudio Ferreira Romanelli
An elevated human T cell leukemia virus type 1 (HTLV-1) proviral load (PVL) is an important risk factor for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), although there is a considerable frequency of asymptomatic carriers (AC) with high PVL in blood. Our objective was to evaluate whether PVL quantified in cerebrospinal fluid (CSF) is helpful to distinguish AC from HAM when AC have high PVL in blood (ACH ). ACH (n = 7) were characterized to have high PVL in blood by quantification of samples collected over time (mean 7 years)...
March 27, 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29584710/mobility-enhancement-in-amorphous-in-ga-zn-o-thin-film-transistor-by-induced-metallic-in-nanoparticles-and-cu-electrodes
#15
Shiben Hu, Honglong Ning, Kuankuan Lu, Zhiqiang Fang, Yuzhi Li, Rihui Yao, Miao Xu, Lei Wang, Junbiao Peng, Xubing Lu
In this work, we fabricated a high-mobility amorphous indium-gallium-zinc-oxide (a-IGZO) thin-film transistor (TFT) based on alumina oxide (Al 2 O 3 ) passivation layer (PVL) and copper (Cu) source/drain electrodes (S/D). The mechanism of the high mobility for a-IGZO TFT was proposed and experimentally demonstrated. The conductivity of the channel layer was significantly improved due to the formation of metallic In nanoparticles on the back channel during Al 2 O 3 PVL sputtering. In addition, Ar atmosphere annealing induced the Schottky contact formation between the Cu S/D and the channel layer caused by Cu diffusion...
March 27, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29581084/beyond-the-5-year-horizon-long-term-outcome-of-high-risk-and-inoperable-patients-undergoing-tavr-with-first-generation-devices
#16
Marcus-André Deutsch, Magdalena Erlebach, Melchior Burri, Alexander Hapfelmeier, Olivia Ganga Witt, Johannes Amadeus Ziegelmueller, Michael Wottke, Hendrik Ruge, Markus Krane, Nicolo Piazza, Sabine Bleiziffer, Rüdiger Lange
AIMS: We sought to determine the long-term outcome of high-risk patients who underwent transcatheter aortic valve replacement (TAVR) with first-generation devices with a focus on an identification of predictors for mortality and valve durability. METHODS AND RESULTS: Consecutive patients in our prospective single-center registry undergoing TAVR with first-generation devices (n=214 CoreValve; n=86 Sapien) between 06/2007 and 07/2009 were retrospectively analysed (n=300, mean age 81...
March 27, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29571899/corrigendum-to-panton-valentine-leucocidin-pvl-staphylococcus-aureus-a-position-statement-from-the-international-society-of-chemotherapy-international-journal-of-antimicrobial-agents-51-1-2018-16-25
#17
Kordo Saeed, Ian Gould, Silvano Esposito, Nusreen Ahmad-Saeed, Salman Shaheer Ahmed, Emine Alp, Abhijit M Bal, Matteo Bassetti, Eric Bonnet, Monica Chan, Geoffrey Coombs, Stephanie J Dancer, Michael Z David, Giuseppe De Simone, Matthew Dryden, Luca Guardabassi, Leif G Hanitsch, Karolin Hijazi, Renate Kruger, Andie Lee, Rasmus Leistner, Pasquale Pagliano, Elda Righi, Sylke Schneider-Burrus, Robert Leo Skov, Pierre Tattevin, Willem VanWamel, Margreet C Vos, Andreas Voss
No abstract text is available yet for this article.
March 20, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29571617/alcohol-injection-into-the-portal-vein-prior-to-ligation-increases-liver-regeneration-rate
#18
Nadia Russolillo, Serena Langella, Serena Perotti, Annalisa Balbo Mussetto, Roberto Lo Tesoriere, Stefano Cirillo, Giovanni De Rosa, Alessandro Ferrero
BACKGROUND: Failure of portal vein ligation (PVL) to induce hypertrophy is not uncommon. The aim of the study was to evaluate the impact of intraportal alcohol injection prior to ligation on liver regeneration. METHOD: Forty-two patients with colorectal liver metastases who underwent PVL between 01/2004 and 06/2014 were analyzed. Beginning in 09/2011, alcohol was injected prior to PVL. Patients treated with PVL alone (Alc- group) were compared with those treated with alcohol injection plus PVL (Alc+ group)...
March 20, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29570211/valve-in-valve-implantation-of-the-corevalve-evolut-r-in-degenerated-surgical-aortic-valves
#19
Marius Schwerg, Karl Stangl, Michael Laule, Verena Stangl, Henryk Dreger
BACKGROUND: The new CoreValve Evolut R has an improved design to minimize paravalvular leakage (PVL) and allows repositioning of the valve. For patients with degenerated bioprosthetic aortic valves, transcatheter aortic valve implantation (TAVI) represents a less invasive option. Herein reported are valve-in-valve (ViV) implantations of this new valve. METHODS: A total of 26 patients (mean age 79.4 ± 6.1 years, 17 males and 9 females) were treated for severe prosthesis stenosis (n = 9), severe regurgitation (n = 8) or severe combination of stenosis and regurgitation (n = 9)...
March 23, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29568515/prevalence-and-molecular-characterization-of-staphylococcus-aureus-from-human-stool-samples
#20
A E Kates, D Thapaliya, T C Smith, M L Chorazy
Background: To determine the prevalence of intestinal S. aureus colonization of patients at a large teaching hospital and determine the molecular characteristics of the identified strains. The second objective of this research was to determine risk factors associated with S. aureus intestinal colonization. Methods: A cross-sectional study of 781 specimens from inpatients and outpatients at the University of Iowa Hospitals and Clinics Clinical Microbiology Laboratory was conducted...
2018: Antimicrobial Resistance and Infection Control
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