keyword
https://read.qxmd.com/read/38533053/il-22-promotes-liver-regeneration-after-portal-vein-ligation
#1
JOURNAL ARTICLE
Tao Zhang, Philipp Seeger, Yashin Simsek, Morsal Sabihi, Jöran Lücke, Dimitra E Zazara, Ahmad Mustafa Shiri, Jan Kempski, Tom Blankenburg, Lilan Zhao, Ioannis Belios, Andres Machicote, Baris Mercanoglu, Mohammad Fard-Aghaie, Sara Notz, Panagis M Lykoudis, Marius Kemper, Tarik Ghadban, Oliver Mann, Thilo Hackert, Jakob R Izbicki, Thomas Renné, Samuel Huber, Anastasios D Giannou, Jun Li
BACKGROUND: Insufficient remnant liver volume (RLV) after the resection of hepatic malignancy could lead to liver failure and mortality. Portal vein ligation (PVL) prior to hepatectomy is subsequently introduced to increase the remnant liver volume and improve the outcome of hepatic malignancy. IL-22 has previously been reported to promote liver regeneration, while facilitating tumor development in the liver via Steap4 upregulation. Here we performed PVL in mouse models to study the role of IL-22 in liver regeneration post-PVL...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38524136/detection-of-staphylococcus-aureus-virulence-gene-pvl-based-on-crispr-strip
#2
JOURNAL ARTICLE
Li Jin, XiaoFeng Hu, Yuan Tian, MengYa Fang, Xue Dong, YaXuan Jiang, Yao Han, Hao Li, Yansong Sun
INTRODUCTION: Staphylococcus aureus ( S. aureus ) is a prominent pathogen responsible for both hospital-acquired and community-acquired infections. Among its arsenal of virulence factors, Panton-Valentine Leucocidin (PVL) is closely associated with severe diseases such as profound skin infections and necrotizing pneumonia. Patients infected with pvl -positive S. aureus often exhibit more severe symptoms and carry a substantially higher mortality risk. Therefore, it is crucial to promptly and accurately detect pvl -positive S...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38517007/neurosonographic-findings-in-infants-with-rhesus-hemolytic-disease-of-newborn-a-prospective-observational-study
#3
JOURNAL ARTICLE
Swapna Bayye, Jogender Kumar, Subhas Chandra Saha, Sourabh Dutta, Praveen Kumar
We estimated the incidence of intraventricular hemorrhage (IVH) and/or periventricular leukomalacia/echogenicity (PVL/E) in Rhesus isoimmunized infants. Seventy-one infants underwent cranial ultrasound within the first 3 days of life or discharge, whichever was earlier. Of these, 27(38%) infants had IVH/ PVL/E. On multivariate analysis, lower gestational age (P = 0.035), small for gestational age [aOR (95% CI) 10.6 (1.9, 58.9)], and sepsis [aOR (95% CI) 4.5 (1.1, 18.4)] were ndependently associated with IVH/PVL...
March 19, 2024: Indian Pediatrics
https://read.qxmd.com/read/38510896/survival-rates-of-extremely-low-birth-weight-infants-in-a-tertiary-care-center-in-saudi-arabia
#4
JOURNAL ARTICLE
Mohammad Alhasoon
Introduction Extremely low birth weight (ELBW) refers to the condition in which an infant is born with a weight of less than one thousand grams (2.2 pounds) at birth. ELBW infants face significant challenges and are at increased risk for various medical complications and developmental issues. ELBW poses unique challenges for infants, families, and healthcare providers. Understanding the causes, consequences, and appropriate management strategies for ELBW is crucial for improving the survival rates of these vulnerable infants...
February 2024: Curēus
https://read.qxmd.com/read/38508338/a-case-of-refractory-disseminated-subcutaneous-abscess-with-intrahousehold-transmission-by-a-usa300-lv-like-strain-of-pvl-positive-community-acquired-mrsa-clone
#5
Wakaki Kami, Motoo Baba, Tetsu Chinen, Jiro Fujita, Tetsuo Yamaguchi
A 44-year-old man with hypertension and dyslipidemia presented with pain in the buttocks. The patient was diagnosed with perianal ischiorectal fossa abscesses and cellulitis. He was subsequently diagnosed with a perineal subcutaneous abscess after a week, a right lower leg impetigo after a month, right periorchitis, a scrotal abscess, and Fournier's gangrene after two months. The patient was treated with various antimicrobials and underwent incisional drainage. Methicillin-resistant Staphylococcus aureus (MRSA) was detected in all draining specimens...
March 18, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/38505530/staphylococcus-aureus-panton-valentine-leukocidin-worsens-acute-implant-associated-osteomyelitis-in-humanized-brgsf-mice
#6
JOURNAL ARTICLE
Marloes I Hofstee, Claudia Siverino, Motoo Saito, Himanshu Meghwani, James Tapia-Dean, Samson Arveladze, Maria Hildebrand, Javier Rangel-Moreno, Martijn Riool, Stephan Zeiter, Sebastian A J Zaat, T Fintan Moriarty, Gowrishankar Muthukrishnan
Staphylococcus aureus is the most common pathogen that causes implant-associated osteomyelitis, a clinically incurable disease. Immune evasion of S. aureus relies on various mechanisms to survive within the bone niche, including the secretion of leukotoxins such as Panton-Valentine leukocidin (PVL). PVL is a pore-forming toxin exhibiting selective human tropism for C5a receptors (C5aR1 and C5aR2) and CD45 on neutrophils, monocytes, and macrophages. PVL is an important virulence determinant in lung, skin and soft tissue infections...
February 2024: JBMR Plus
https://read.qxmd.com/read/38496184/successful-rescue-transaortic-valve-replacement-using-edwards-sapien-3-following-failed-evolut-r-implantation-in-a-degenerated-surgical-bioprosthesis-a-case-report
#7
Victor H Molina-Lopez, Eduardo Partida-Rodriguez, Jaime Rivera-Babilonia, Luis Rodriguez-Ospina
This study examines a complex scenario of structural valve degeneration (SVD) in a high surgical-risk patient with a previously implanted 25 mm Carpentier-Edwards (CE) Perimount Magna Ease 3300 (Irvine, CA: Edwards Lifesciences) surgical bioprosthetic valve (SAV), the patient presented with both paravalvular leak (PVL) and central prosthetic valve insufficiency (PVI). The patient was considered for a transaortic valve-in-valve (ViV) intervention with a self-expanding 29 mm Evolut R valve (Minneapolis, MN: Medtronic)...
February 2024: Curēus
https://read.qxmd.com/read/38488293/enabling-closed-loop-circularity-of-non-polymerizable-%C3%AE-%C3%AE-conjugated-lactone-towards-high-performance-polyester-with-the-assistance-of-cyclopentadiene
#8
JOURNAL ARTICLE
Xiao-Tong Wu, Chun Yang, Jian-Shu Xi, Changxia Shi, Fu-Sheng Du, Zi-Chen Li
Chemical recycling of polymers to monomers presents a promising solution to the escalating crisis associated with plastic waste. Despite considerable progress made in this field, the primary efforts have been focused on redesigning new monomers to produce readily recyclable polymers. In contrast, limited research into the potential of seemingly "non-polymerizable" monomers has been conducted. Herein, we propose a paradigm that leverages a "chaperone"-assisted strategy to establish closed-loop circularity for a "non-polymerizable" α, β-conjugated lactone, 5,6-dihydro-2H-pyran-2-one (DPO)...
March 15, 2024: Angewandte Chemie
https://read.qxmd.com/read/38487883/antimicrobial-resistance-and-virulence-profiling-of-staphylococcus-pseudintermedius-isolated-from-cats-bangladesh
#9
JOURNAL ARTICLE
Eaftekhar Ahmed Rana, Tanvir Ahmad Nizami, Md Sayedul Islam, Subrata Sarker, Hafizar Rahman, Azizul Hoque, Mizanur Rahman
Staphylococcus pseudintermedius is a significant bacterial pathogen that frequently colonizes different body sites and mucous membranes of pets. The objectives of the cross-sectional study were to estimate the prevalence, antimicrobial resistance pattern, and detection of diverse resistance as well as virulence genes of S. pseudintermedius in cats. A standard bacteriological method, species-specific gene and different antimicrobial resistance as well as virulence genes were confirmed by PCR assay. A total of 233 swab samples were collected from different body sites of 102 cats, among them 146 swabs from 73 healthy cats, and 87 from 29 diseased cats...
December 2024: Veterinary Quarterly
https://read.qxmd.com/read/38482361/clinical-impact-and-public-health-challenges-of-a-pvl-mrsa-bacteraemia-outbreak-amongst-people-who-inject-drugs-in-south-yorkshire-uk
#10
JOURNAL ARTICLE
Matthew Beaumont, Bala Subramanian, Ken Agwuh, Yan Ryan, Bruno Pichon
BACKGROUND: Panton-Valentine leukocidin (PVL) Staphylococcus aureus (SA) is an emergent public health concern. PVL toxin has been mostly associated with methicillin-sensitive S. aureus (MSSA)-related skin and soft tissue infections occurring in high-risk groups such as people who inject drugs (PWID). The emergence of PVL methicillin-resistant S. aureus (MRSA) infection is causing severe and life-threatening disease in PWID. CLINICAL CASES: We present an outbreak of eight PVL-MRSA bacteraemia cases at a UK teaching hospital between 2018 and 2022...
2024: Access microbiology
https://read.qxmd.com/read/38471156/virtual-reality-to-predict-paravalvular-leak-in-bicuspid-severe-aortic-valve-stenosis-in-transcatheter-aortic-valve-implants
#11
JOURNAL ARTICLE
Johnny Chahine, Lorraine Mascarenhas, Demetris Yannopoulos, Ganesh Raveendran, Sergey Gurevich
OBJECTIVES: Severe aortic stenosis (AS) in bicuspid aortic valves (BAV) is associated with an increased risk of paravalvular leak (PVL) after a transcatheter aortic valve replacement (TAVR). Virtual reality (VR) has been shown to be an effective tool in surgical training, but its utility in clinical practice has not been studied. Here we present the first study to evaluate the use of VR simulation in pre-procedure planning and prediction of PVL in TAVR in patients with severe BAV AS. METHODS: Twenty-two patients with severe BAV AS undergoing TAVR between 2014 and 2018 at the University of Minnesota were included in the study...
March 11, 2024: Journal of Invasive Cardiology
https://read.qxmd.com/read/38470881/insights-from-a-decade-of-surveillance-molecular-epidemiology-of-methicillin-resistant-staphylococcus-aureus-in-norway-from-2008-to-2017
#12
JOURNAL ARTICLE
Torunn Gresdal Rønning, Hege Enger, Jan Egil Afset, Christina Gabrielsen Ås
AIM: Norway has a low prevalence of methicillin-resistant Staphylococcus aureus (MRSA) and reporting of all MRSA cases has been mandatory, including infections and carriage, since 1995 and 2005 accordingly. This provides a unique window to study the spread of MRSA in Norway over time. The aim of this study was to analyze the nationwide trends in the molecular epidemiology of MRSA in Norway over a period of 10 years. METHODS: Clinical and epidemiological data as well as bacterial genotype (spa-type and PVL) were analyzed for all reported MRSA cases in Norway in the period 2008-2017...
2024: PloS One
https://read.qxmd.com/read/38456883/real-world-outcomes-for-the-fifth-generation-balloon-expandable-transcatheter-heart-valve-in-the-united%C3%A2-states
#13
JOURNAL ARTICLE
Curtiss T Stinis, Amr E Abbas, Paul Teirstein, Raj R Makkar, Christine J Chung, Vijay Iyer, Philippe Généreux, Robert M Kipperman, John K Harrison, G Chad Hughes, Jefferson M Lyons, Ayaz Rahman, Nikolaos Kakouros, Jennifer Walker, David K Roberts, Pei-Hsiu Huang, Biswajit Kar, Abhijeet Dhoble, Daniel P Logsdon, Puneet K Khanna, Joseph Aragon, James M McCabe
BACKGROUND: The fifth-generation SAPIEN 3 Ultra Resilia valve (S3UR) incorporates several design changes as compared with its predecessors, the SAPIEN 3 (S3) and SAPIEN 3 Ultra (S3U) valves, including bovine leaflets treated with a novel process intended to reduce structural valve deterioration via calcification, as well as a taller external skirt on the 29-mm valve size to reduce paravalvular leak (PVL). The clinical performance of S3UR compared with S3 and S3U in a large patient population has not been previously reported...
February 29, 2024: JACC. Cardiovascular Interventions
https://read.qxmd.com/read/38455385/self-healing-and-shape-memory-polymers-based-on-cellulose-acetate-matrix
#14
JOURNAL ARTICLE
Han Jia, Keiya Jimbo, Hirogi Yokochi, Hideyuki Otsuka, Tsuyoshi Michinobu
The creation of self-healing polymers with superior strength and stretchability from biodegradable materials is attracting increasing attention. In this study, we synthesized new biomass-derived cellulose acetate (CA) derivatives by ring-opening graft polymerization of δ-valerolactone followed by the introduction of ureidopyrimidinone (Upy) groups in the polymer side chains. Due to the semicrystalline aliphatic characteristics of the side chain poly(δ-valerolactone) (PVL) and quadruple hydrogen bonds formed by the Upy groups, the stretchability of the resulting polymers was significantly enhanced...
2024: Science and Technology of Advanced Materials
https://read.qxmd.com/read/38450376/intravascular-lithotripsy-ivl-enabled-the-percutaneous-closure-of-a-severely-calcified-paravalvular-leak-regurgitation-following-implantation-of-a-self-expandable-transcatheter-aortic-valve-a-case-report
#15
Salvatore Evola, Alessandro D'Agostino, Daniele Adorno, Oreste Fabio Triolo, Gioacchino Giarratana, Sebastiano Castrovinci, Vincenzo Argano, Eustaquio Maria Onorato
BACKGROUND: Closure of paravalvular leak (PVL) regurgitation after self-expandable (SE) transcatheter aortic valve implantation (TAVI) may be more challenging than after balloon-expandable (BE) valve implantation. CASE SUMMARY: An 85-year-old woman suffering from long-standing atrial fibrillation and severe symptomatic aortic stenosis underwent SE TAVI (26 mm Evolut™ R®, Medtronic Inc., MN, USA). A total of eighteen months after TAVI she was admitted for congestive heart failure and two-dimensional (2D) transesophageal echocardiography (TEE) color Doppler showed moderate-severe PVL regurgitation due to a long and heavily calcified leak located below the left coronary sinus...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38446025/optimal-oversizing-in-transcatheter-aortic-valve-replacement-with-the-self-expanding-evolut-valve-system
#16
JOURNAL ARTICLE
Silvia Mas-Peiro, Alberto Alperi, Marisa Avvedimento, Ander Regueiro, Pablo Avanzas, Domenico Angellotti, Giovanni Esposito, Pablo Vidal-Cales, Siamak Mohammadi, Julio Farjat, Cesar Moris, Josep Rodés-Cabau
OBJECTIVES: Valve oversizing has been associated with reduced paravalvular leaks (PVL) and valve migration risk. However, no optimal cut-off oversizing value has been defined for the Evolut system (Medtronic). The aim of this study was to assess the relationship between the degree of oversizing and moderate-to-severe PVL and determine the optimal oversizing cut-off value. METHODS: We conducted a multicenter study that included 740 consecutive patients with multidetector computed tomography (CT) data...
March 4, 2024: Journal of Invasive Cardiology
https://read.qxmd.com/read/38437930/complications-in-transcatheter-aortic-valve-replacement-a-comprehensive-analysis-and-management-strategies
#17
REVIEW
Qi Zou, Zhiliang Wei, Shougang Sun
Transcatheter Aortic Valve Replacement (TAVR) marks a significant advancement in treating aortic stenosis (AS), especially for patients with high surgical risks. This concise review outlines TAVR's development, its broader application to include lower-risk patients, and innovations in device and procedural technology. Clinical trials, notably the PARTNER series, affirm TAVR's efficacy, showing it matches or surpasses surgical aortic valve replacement (SAVR) in mortality reduction, hemodynamic benefits, and symptom alleviation, including heart failure...
March 2, 2024: Current Problems in Cardiology
https://read.qxmd.com/read/38437463/antimicrobial-resistance-and-the-prevalence-of-the-panton-valentine-leukocidin-gene-among-clinical-isolates-of-staphylococcus-aureus-in-lithuania
#18
JOURNAL ARTICLE
Agnė Kirkliauskienė, Jonas Kriščiūnas, Jolanta Miciulevičienė, Daiva Radzišauskienė, Tomas Kačergius, Maksim Bratchikov, Lina Kaplerienė
This study aimed to determine resistance to antimicrobials of Staphylococcus aureus strains isolated from clinical specimens in Lithuanian hospitals and to identify the genes conferring resistance and virulence. The study was carried out from June 2019 to September 2021. S. aureus strains were isolated from skin, soft tissues, blood, lower respiratory tract, urine and other specimens. Antibiotic susceptibility testing was performed using the disc diffusion method according to EUCAST guidelines. All isolates were analyzed for detection of the ermA , ermC , mecA , mecC , tetK , tetM , and lukF-PV genes by multiplex real-time PCR...
March 1, 2024: Polish Journal of Microbiology
https://read.qxmd.com/read/38432260/inosine-pretreatment-of-pregnant-rats-ameliorates-maternal-inflammation-mediated-hypomyelination-in-pups-via-microglia-polarization-switch
#19
JOURNAL ARTICLE
Yong Han, Jinping Sun, Xiaojuan, Ma Xin Li, Quanrui Ma
Periventricular leukomalacia (PVL) is a neurological condition observed in premature infants, characterized by hypomyelination and activation of microglia. Maternal inflammation-induced brain injury in offspring significantly contributes to the development of PVL. Currently, there are no clinical pharmaceutical interventions available for pregnant women to prevent maternal inflammation-mediated brain injury in their offspring. Inosine has been shown to modulate the immune response in diverse stressful circumstances, such as injury, ischemia, and inflammation...
March 1, 2024: Brain Research
https://read.qxmd.com/read/38429165/impact-of-the-extent-and-location-of-liver-split-on-future-liver-remnant-hypertrophy-after-portal-vein-ligation-in-a-rat-model
#20
JOURNAL ARTICLE
Xue Chen, Bo Zhou, Shuai Wu, Guangyao Li, Yu Ma, Ping Chen, Geng Chen
BACKGROUND: To investigate the role and mechanism of liver parenchyma transection in accelerating the regeneration of future liver remnants in rats with portal vein ligation (PVL). METHODS: Rats were randomly divided into the PVL group (90% PVL at the caudate lobe, right lobe , left lateral lobe and left median lobe), associating liver partition and portal vein ligation for staged hepatectomy (portal vein ligation with complete liver parenchyma transection [ALPPS]) group (90% PVL with 80 to 90% liver parenchyma transection), PVL + partial liver partition (PLP) group (90% PVL with 30 to 50% liver parenchyma transection), PVL + partition in the ligated lobe (PLL) group (90% PVL with 40 to 60% liver parenchyma transection in the portal vein ligated lobe), PVL + partition in the remnant lobe (PRL) group (90% PVL with 40 to 60% liver parenchyma transection in the remnant lobe), PVL + radiofrequency ablation (RFA) group (90% PVL with splenic ablation) and sham operation (sham) group...
February 29, 2024: Surgery
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