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https://www.readbyqxmd.com/read/29353366/is-invasion-a-necessary-step-for-metastases-in-breast-cancer
#1
REVIEW
Steven A Narod, Victoria Sopik
PURPOSE: To review the empirical evidence to support the conventional (sequential) model of breast cancer progression, which is based on the paradigm that cancer passes through several stages, including an in situ stage prior to an invasive stage, and thereafter (in some cases) disseminates to the lymph nodes and distant organs. METHODS: We review the cancer literature of the last 50 years which relates to the prevention of invasive breast cancer (through radiotherapy or surgery) and reductions in the mortality for breast cancer...
January 20, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29353214/effects-of-poor-sleep-quality-on-brain-functional-connectivity-revealed-by-wavelet-based-coherence-analysis-using-nirs-methods-in-elderly-subjects
#2
Lingguo Bu, Dawei Wang, Congcong Huo, Gongcheng Xu, Zengyong Li, Jianfeng Li
OBJECTIVE: Poor sleep quality, which is typically related to impairments in cognitive control, is pervasive among the elderly. However, the brain function mechanisms underlying the association between sleep and elderly behavior remain elusive. This study aims to assess the effects of poor sleep quality on low-frequency neural oscillations based on the wavelet phase coherence (WPCO) and wavelet amplitude (WA) of oxyhemoglobin concentration changes (Delta [HbO2]) measured through near-infrared spectroscopy (NIRS) method...
January 17, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29353165/prognostic-value-of-primary-tumour-resection-in-synchronous-metastatic-colorectal-cancer-individual-patient-data-analysis-of-first-line-randomised-trials-from-the-arcad-database
#3
K L van Rooijen, Q Shi, K K H Goey, J Meyers, V Heinemann, E Diaz-Rubio, E Aranda, A Falcone, E Green, A de Gramont, D J Sargent, C J A Punt, M Koopman
Indication for primary tumour resection (PTR) in asymptomatic metastatic colorectal cancer (mCRC) patients is unclear. Previous retrospective analyses suggest a survival benefit for patients who underwent PTR. The aim was to evaluate the prognostic value of PTR in patients with synchronous mCRC by analysis of recent large RCTs including systemic therapy with modern targeted agents. Individual patient data (IPD) of 3423 patients enrolled into 8 randomised controlled trials (RCTs) with first-line systemic therapy in the ARCAD (Aide et Recherche en Cancérologie Digestive) database were analysed...
January 17, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29352501/predictors-of-beef-calf-temperament-at-weaning-and-its-impact-on-temperament-at-breeding-and-reproductive-performance
#4
V R Kasimanickam, R L Abdel Aziz, H M Williams, R K Kasimanickam
Two experiments were conducted to determine (i) factors influencing calf temperament at weaning, (ii) association between heifer-calf temperament at weaning and temperament at breeding and (iii) effect of heifer-calf temperament on pregnancy rate per artificial insemination (P/AI). In experiment 1, beef cows and their calves (n = 285) from three farms were used. Sire docility estimated progeny difference (EPD) score, birth type (normal or assisted), calf gender, calf behaviour (during 1st 4 weeks) and calf health status (until weaning) were recorded...
January 19, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29352256/time-management-in-a-co-housed-social-rodent-species-arvicanthis-niloticus
#5
Alexandra Castillo-Ruiz, Premananda Indic, William J Schwartz
Sociality has beneficial effects on fitness, and timing the activities of animals may be critical. Social cues could influence daily rhythmic activities via direct effects on the circadian clock or on processes that bypass it (masking), but these possibilities remain incompletely addressed. We investigated the effects of social cues on the circadian body temperature (Tb) rhythms in pairs of co-housed and isolated grass rats, Arvicanthis niloticus (a social species), in constant darkness (DD). Cohabitation did not induce synchronization of circadian Tb rhythms...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29351813/integrated-biogeography-of-planktonic-and-sedimentary-bacterial-communities-in-the-yangtze-river
#6
Tang Liu, An Ni Zhang, Jiawen Wang, Shufeng Liu, Xiaotao Jiang, Chenyuan Dang, Tao Ma, Sitong Liu, Qian Chen, Shuguang Xie, Tong Zhang, Jinren Ni
BACKGROUND: Bacterial communities are essential to the biogeochemical cycle in riverine ecosystems. However, little is presently known about the integrated biogeography of planktonic and sedimentary bacterial communities in large rivers. RESULTS: This study provides the first spatiotemporal pattern of bacterial communities in the Yangtze River, the largest river in Asia with a catchment area of 1,800,000 km2. We find that sedimentary bacteria made larger contributions than planktonic bacteria to the bacterial diversity of the Yangzte River ecosystem with the sediment subgroup providing 98...
January 19, 2018: Microbiome
https://www.readbyqxmd.com/read/29351764/quantification-and-kinetics-of-viral-rna-transcripts-produced-in-orthohantavirus-infected-cells
#7
Julia Wigren Byström, Jonas Näslund, Fredrik Trulsson, Magnus Evander, Olivia Wesula Lwande, Clas Ahlm, Göran Bucht
BACKGROUND: Rodent borne viruses of the Orthohantavirus genus cause hemorrhagic fever with renal syndrome among people in Eurasia, and hantavirus cardiopulmonary syndrome in the Americas. At present, there are no specific treatments or efficient vaccines against these diseases. Improved understanding of viral transcription and replication may instigate targeted treatment of Orthohantavirus infections. For this purpose, we investigated the kinetics and levels of viral RNA transcription during an ongoing infection in-vitro...
January 19, 2018: Virology Journal
https://www.readbyqxmd.com/read/29351051/voluntary-ambulation-using-voluntary-upper-limb-muscle-activity-and-hybrid-assistive-limb%C3%A2-hal%C3%A2-in-a-patient-with-complete-paraplegia-due-to-chronic-spinal-cord-injury-a-case-report
#8
Yukiyo Shimizu, Hideki Kadone, Shigeki Kubota, Kenji Suzuki, Kousaku Saotome, Tomoyuki Ueno, Tetsuya Abe, Aiki Marushima, Hiroki Watanabe, Ayumu Endo, Kazue Tsurumi, Ryu Ishimoto, Akira Matsushita, Masao Koda, Akira Matsumura, Yoshiyuki Sankai, Yasushi Hada, Masashi Yamazaki
CONTEXT: We sought to describe our experience with the Hybrid Assistive Limb® (HAL®) for active knee extension and voluntary ambulation with remaining muscle activity in a patient with complete paraplegia after spinal cord injury. FINDINGS: A 30-year-old man with complete paraplegia used the HAL® for 1 month (10 sessions) using his remaining muscle activity, including hip flexor and upper limb activity. Electromyography was used to evaluate muscle activity of the gluteus maximus, tensor fascia lata, quadriceps femoris, and hamstring muscles in synchronization with the Vicon motion capture system...
January 19, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29350452/anatomical-and-phenological-implications-between-schinus-polygama-cav-cabrera-anacardiaceae-and-the-galling-insect-calophya-rubra-blanchard-hemiptera-psylloidea
#9
Lubia M Guedes, Narciso Aguilera, Bruno G Ferreira, José Becerra, Victor Hernández, Rosy Ms Isaias
The success of galling insects could be determined by synchronization with host plant phenology and climatic conditions, ensuring suitable oviposition sites for gall induction and food resources for their survivorship. The anatomical, histochemical and phenological synchronization strategies between Calophya rubra (Blanchard) (Hemiptera: Psylloidea) and its host, the evergreen plant Schinus polygama (Cav.) (Cabrera) (Anacardiaceae), in the Mediterranean climate of southern Chile was herein evaluated, and was compared to that of the congeneric C...
January 19, 2018: Plant Biology
https://www.readbyqxmd.com/read/29349759/readdressing-the-role-of-surgery-of-the-primary-tumor-in-de-novo-stage-iv-breast-cancer
#10
Seema Ahsan Khan, Elizabeth S M DesJardin
The impressive advances in breast cancer treatment observed in recent years also apply to the metastatic setting, where a subset of patients with favorable metastatic disease enjoy long-term survival with systemic therapy. In patients with distant disease, the primary tumor in the breast has not classically been though to merit specific locoregional therapy. However, about 6% of Stage IV patients in the USA and up to 20% in limited resource environments present with synchronous distant metastases at the time of initial diagnosis...
2018: Cancer Treatment and Research
https://www.readbyqxmd.com/read/29349302/fast-noise-free-memory-for-photon-synchronization-at-room-temperature
#11
Ran Finkelstein, Eilon Poem, Ohad Michel, Ohr Lahad, Ofer Firstenberg
Future quantum photonic networks require coherent optical memories for synchronizing quantum sources and gates of probabilistic nature. We demonstrate a fast ladder memory (FLAME) mapping the optical field onto the superposition between electronic orbitals of rubidium vapor. Using a ladder-level system of orbital transitions with nearly degenerate frequencies simultaneously enables high bandwidth, low noise, and long memory lifetime. We store and retrieve 1.7-ns-long pulses, containing 0.5 photons on average, and observe short-time external efficiency of 25%, memory lifetime (1/e) of 86 ns, and below 10-4 added noise photons...
January 2018: Science Advances
https://www.readbyqxmd.com/read/29349282/does-non-standard-work-mean-non-standard-health-exploring-links-between-non-standard-work-schedules-health-behavior-and-well-being
#12
Megan R Winkler, Susan Mason, Melissa N Laska, Mary J Christoph, Dianne Neumark-Sztainer
The last century has seen dramatic shifts in population work circumstances, leading to an increasing normalization of non-standard work schedules (NSWSs), defined as non-daytime, irregular hours. An ever-growing body of evidence links NSWSs to a host of non-communicable chronic conditions; yet, these associations primarily concentrate on the physiologic mechanisms created by circadian disruption and insufficient sleep. While important, not all NSWSs create such chronobiologic disruption, and other aspects of working time and synchronization could be important to the relationships between work schedules and chronic disease...
April 2018: SSM—Population Health
https://www.readbyqxmd.com/read/29349038/abnormal-neural-hierarchy-in-processing-of-verbal-information-in-patients-with-schizophrenia
#13
Yulia Lerner, Maya Bleich-Cohen, Shimrit Solnik-Knirsh, Galit Yogev-Seligmann, Tamir Eisenstein, Waheed Madah, Alon Shamir, Talma Hendler, Ilana Kremer
Previous research indicates abnormal comprehension of verbal information in patients with schizophrenia. Yet the neural mechanism underlying the breakdown of verbal information processing in schizophrenia is poorly understood. Imaging studies in healthy populations have shown a network of brain areas involved in hierarchical processing of verbal information over time. Here, we identified critical aspects of this hierarchy, examining patients with schizophrenia. Using functional magnetic resonance imaging, we examined various levels of information comprehension elicited by naturally presented verbal stimuli; from a set of randomly shuffled words to an intact story...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29348367/a-pathway-for-mitotic-chromosome-formation
#14
Johan H Gibcus, Kumiko Samejima, Anton Goloborodko, Itaru Samejima, Natalia Naumova, Johannes Nuebler, Masato T Kanemaki, Linfeng Xie, James R Paulson, William C Earnshaw, Leonid A Mirny, Job Dekker
Mitotic chromosomes fold as compact arrays of chromatin loops. To identify the pathway of mitotic chromosome formation, we combined imaging and Hi-C of synchronous DT40 cell cultures with polymer simulations. We show that in prophase, the interphase organization is rapidly lost in a condensin-dependent manner and arrays of consecutive 60 kb loops are formed. During prometaphase ~80 kb inner loops are nested within ~400 kb outer loops. The loop array acquires a helical arrangement with consecutive loops emanating from a central spiral-staircase condensin scaffold...
January 18, 2018: Science
https://www.readbyqxmd.com/read/29348148/replication-timing-kept-in-line
#15
Rachel J O'Neill, Michael J O'Neill
Accurate and synchronous replication timing between chromosome homologues is essential for maintaining chromosome stability, yet how this is achieved has remained a mystery. In this issue, Platt et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201707082) identify antisense LINE (L1) transcripts within long noncoding RNAs as the critical factor in maintaining synchronous chromosome-wide replication timing.
January 18, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29347806/synchrony-induced-modes-of-oscillation-of-a-neural-field-model
#16
Jose M Esnaola-Acebes, Alex Roxin, Daniele Avitabile, Ernest Montbrió
We investigate the modes of oscillation of heterogeneous ring networks of quadratic integrate-and-fire (QIF) neurons with nonlocal, space-dependent coupling. Perturbations of the equilibrium state with a particular wave number produce transient standing waves with a specific temporal frequency, analogously to those in a tense string. In the neuronal network, the equilibrium corresponds to a spatially homogeneous, asynchronous state. Perturbations of this state excite the network's oscillatory modes, which reflect the interplay of episodes of synchronous spiking with the excitatory-inhibitory spatial interactions...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347798/dispersion-of-the-intrinsic-neuronal-periods-affects-the-relationship-of-the-entrainment-range-to-the-coupling-strength-in-the-suprachiasmatic-nucleus
#17
Changgui Gu, Huijie Yang, Man Wang
Living beings on the Earth are subjected to and entrained (synchronized) to the natural 24-h light-dark cycle. Interestingly, they can also be entrained to an external artificial cycle of non-24-h periods. The range of these periods is called the entrainment range and it differs among species. In mammals, the entrainment range is regulated by a main clock located in the suprachiasmatic nucleus (SCN) which is composed of 10 000 neurons in the brain. Previous works have found that the entrainment range depends on the cellular coupling strength in the SCN...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347775/mode-locking-in-systems-of-globally-coupled-phase-oscillators
#18
Sebastian Eydam, Matthias Wolfrum
We investigate the dynamics of a Kuramoto-type system of globally coupled phase oscillators with equidistant natural frequencies and a coupling strength below the synchronization threshold. It turns out that in such cases one can observe a stable regime of sharp pulses in the mean field amplitude with a pulsation frequency given by spacing of the natural frequencies. This resembles a process known as mode locking in lasers and relies on the emergence of a phase relation induced by the nonlinear coupling. We discuss the role of the first and second harmonics in the phase-interaction function for the stability of the pulsations and present various bifurcating dynamical regimes such as periodically and chaotically modulated mode locking, transitions to phase turbulence, and intermittency...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347755/transition-to-synchrony-in-degree-frequency-correlated-sakaguchi-kuramoto-model
#19
Prosenjit Kundu, Pitambar Khanra, Chittaranjan Hens, Pinaki Pal
We investigate transition to synchrony in degree-frequency correlated Sakaguchi-Kuramoto (SK) model on complex networks both analytically and numerically. We analytically derive self-consistent equations for group angular velocity and order parameter for the model in the thermodynamic limit. Using the self-consistent equations we investigate transition to synchronization in SK model on uncorrelated scale-free (SF) and Erdős-Rényi (ER) networks in detail. Depending on the degree distribution exponent (γ) of SF networks and phase-frustration parameter, the population undergoes from first-order transition [explosive synchronization (ES)] to second-order transition and vice versa...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347748/asymmetric-couplings-enhance-the-transition-from-chimera-state-to-synchronization
#20
Changhai Tian, Hongjie Bi, Xiyun Zhang, Shuguang Guan, Zonghua Liu
Chimera state has been well studied recently, but little attention has been paid to its transition to synchronization. We study this topic here by considering two groups of adaptively coupled Kuramoto oscillators. By searching the final states of different initial conditions, we find that the system can easily show a chimera state with robustness to initial conditions, in contrast to the sensitive dependence of chimera state on initial conditions in previous studies. Further, we show that, in the case of symmetric couplings, the behaviors of the two groups are always complementary to each other, i...
November 2017: Physical Review. E
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