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https://www.readbyqxmd.com/read/28651108/synchronous-characterization-of-carbohydrates-and-ginsenosides-yields-deeper-insights-into-the-processing-chemistry-of-ginseng
#1
Shan-Shan Zhou, Jun Xu, Ming Kong, Ka-Man Yip, Jin-Di Xu, Hong Shen, Zhong-Zhen Zhao, Song-Lin Li, Hu-Biao Chen
Carbohydrates and ginsenosides in ginseng are biologically interrelated. Their synchronous analysis is therefore essential in chemical research on ginseng to characterize its "holistic" quality. Here we investigated the processing chemistry of red ginseng (RG), a ginseng product processed by water-steaming, for which both carbohydrates and ginsenosides were qualitatively and quantitatively determined through multiple analytical techniques. Results revealed that the steam-processing not only qualitatively and quantitatively altered the ginsenosides but also affected the polymeric carbohydrates via changing their physiochemical parameters, i...
June 19, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28651048/nutritional-and-metabolic-characteristics-of-brassica-carinata-coproducts-from-biofuel-processing-in-dairy-cows
#2
Yajing Ban, Nazir Ahmad Khan, Peiqiang Yu
The increased utilization of Brassica carinata in the biofuel industry in Canada has resulted in the large scale production of coproducts that can be potentially exploited as alternative protein ingredient in dairy ration. The objectives of this study were to investigate the nutritive value of carinata presscake and meal for dairy cows in terms of (1) nutrient and anti-nutrient composition; (2) rumen degradation kinetics of organic matter (OM), crude protein (CP) and neutral detergent fiber; (3) hourly effective degradation ratio and potential N to energy synchronization; (4) intestinal digestion of rumen undegraded protein (RUP); and (5) total metabolizable protein (MP) supply to the small intestine...
June 26, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28650639/on-site-determination-and-monitoring-of-real-time-fluence-delivery-for-an-operating-uv-reactor-based-on-a-true-fluence-rate-detector
#3
Mengkai Li, Wentao Li, Zhimin Qiang, Ernest R Blatchley
At present, on-site fluence (distribution) determination and monitoring of an operating UV system represents a considerable challenge. The recently developed micro-fluorescent silica detector (MFSD) is able to measure the approximate true fluence rate (FR) at a fixed position in a UV reactor that can be compared with a FR model directly. Hence it has provided a connection between model calculation and real-time fluence determination. In this study, an on-site determination and monitoring method of fluence delivery for an operating UV reactor was developed...
June 26, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28650600/clear-cell-neuroendocrine-tumor-of-the-pancreas-in-von-hippel-lindau-disease-a-case-report-and-literature-review
#4
(no author information available yet)
Clear cell neuroendocrine tumor (NET) of the pancreas is found in von Hippel-Lindau (VHL) disease, multiple endocrine neoplasia type I (MEN I), and sporadic form. Clear cell NETs are often misdiagnosed as metastatic renal cell carcinoma. A 47-year-old woman with VHL was found to have a mass in the pancreatic tail and two masses in the right kidney with two cysts. A distal pancreatectomy and right radical nephrectomy were performed. The pancreatic lesion was a well-circumscribed, golden-yellow solid mass, which was lobulated by septal fibrosis...
May 26, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28650219/interrogating-cell-division-errors-using-random-and-chromosome-specific-missegregation-approaches
#5
Peter Ly, Don W Cleveland
Accurate segregation of the duplicated genome in mitosis is essential for maintaining genetic stability. Errors in this process can cause numerical and/or structural chromosome abnormalities - hallmark genomic features commonly associated with both tumorigenesis and developmental disorders. A cell-based approach was recently developed permitting inducible missegregation of the human Y chromosome by selectively disrupting kinetochore assembly onto the Y centromere. Although this strategy initially requires several steps of genetic manipulation, it is easy to use, highly efficient and specific for the Y without affecting the autosomes or the X, and does not require cell cycle synchronization or mitotic perturbation...
June 26, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28650022/interaction-and-inhibitory-influence-of-the-azo-dye-carmoisine-on-lysozyme-amyloid-fibrillogenesis
#6
Anirban Basu, Gopinatha Suresh Kumar
The binding of the common food colorant carmoisine and its inhibitory effect on amyloid fibrillation in lysozyme have been investigated. Since humans are increasingly exposed to various food colorants like carmoisine, such studies are highly relevant. In the presence of lysozyme, the carmoisine absorption spectrum exhibited hypochromic changes. The intrinsic fluorescence of lysozyme was also quenched on interaction. Time-resolved fluorescence results suggested that the binding mechanism involved ground state complexation...
June 26, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28649434/a-clb-cdk1-mediated-regulation-of-fkh2-synchronizes-clb-expression-in-the-budding-yeast-cell-cycle
#7
Christian Linke, Anastasia Chasapi, Alberto González-Novo, Istabrak Al Sawad, Silvia Tognetti, Edda Klipp, Mart Loog, Sylvia Krobitsch, Francesc Posas, Ioannis Xenarios, Matteo Barberis
Precise timing of cell division is achieved by coupling waves of cyclin-dependent kinase (Cdk) activity with a transcriptional oscillator throughout cell cycle progression. Although details of transcription of cyclin genes are known, it is unclear which is the transcriptional cascade that modulates their expression in a timely fashion. Here, we demonstrate that a Clb/Cdk1-mediated regulation of the Fkh2 transcription factor synchronizes the temporal mitotic CLB expression in budding yeast. A simplified kinetic model of the cyclin/Cdk network predicts a linear cascade where a Clb/Cdk1-mediated regulation of an activator molecule drives CLB3 and CLB2 expression...
2017: NPJ Systems Biology and Applications
https://www.readbyqxmd.com/read/28649217/a-novel-computer-based-set-up-to-study-movement-coordination-in-human-ensembles
#8
Francesco Alderisio, Maria Lombardi, Gianfranco Fiore, Mario di Bernardo
Existing experimental works on movement coordination in human ensembles mostly investigate situations where each subject is connected to all the others through direct visual and auditory coupling, so that unavoidable social interaction affects their coordination level. Here, we present a novel computer-based set-up to study movement coordination in human groups so as to minimize the influence of social interaction among participants and implement different visual pairings between them. In so doing, players can only take into consideration the motion of a designated subset of the others...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28648756/clinicopathologic-features-and-prognosis-of-sporadic-bilateral-renal-cell-carcinoma-a-series-of-148-cases
#9
Nienie Qi, Teng Li, Xianghui Ning, Xiang Peng, Lin Cai, Kan Gong
INTRODUCTION: The purpose of this study was to investigate the clinicopathologic features, treatment, and prognosis of sporadic bilateral renal cell carcinoma (RCC). PATIENTS AND METHODS: A total of 148 patients with sporadic bilateral RCC treated in our center from June 1986 to December 2015 were included in this retrospective study. Their clinicopathologic features and treatments were evaluated. The survival and prognostic factors were assessed based on data from follow-up...
March 28, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28647671/use-of-oncogenic-driver-mutations-in-staging-of-multiple-primary-lung-carcinomas-a-single-center-experience
#10
Ramsey Asmar, Joshua R Sonett, Gopal Singh, Mahesh M Mansukhani, Alain C Borczuk
PURPOSE: The staging of multiple pulmonary adenocarcinomas requires the distinction of intrapulmonary metastasis (IPM) from multiple primary lung cancers (MPLC). This can be challenging in some patients, and the addition of data from oncogenic driver mutations in these tumors may be helpful in this determination. PROCEDURES: As a proof of principle, molecular driver results from primary tumors and their metastases in 45 patients were compared (cohort 1). Then, 69 patients with a total of 154 synchronous or metachronous lung carcinomas were identified, with pathologic findings compared to oncogenic driver mutation...
June 21, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28647049/targeting-of-regulated-necrosis-in-kidney-disease
#11
Diego Martin-Sanchez, Jonay Poveda, Miguel Fontecha-Barriuso, Olga Ruiz-Andres, María Dolores Sanchez-Niño, Marta Ruiz-Ortega, Alberto Ortiz, Ana Belén Sanz
The term acute tubular necrosis was thought to represent a misnomer derived from morphological studies of human necropsies and necrosis was thought to represent an unregulated passive form of cell death which was not amenable to therapeutic manipulation. Recent advances have improved our understanding of cell death in acute kidney injury. First, apoptosis results in cell loss, but does not trigger an inflammatory response. However, clumsy attempts at interfering with apoptosis (e.g. certain caspase inhibitors) may trigger necrosis and, thus, inflammation-mediated kidney injury...
June 21, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28646920/dynamics-of-th9-cells-and-their-potential-role-in-immunopathogenesis-of-murine-schistosomiasis
#12
Tingzheng Zhan, Tingting Zhang, Yanyan Wang, Xiaoli Wang, Cai Lin, Huihui Ma, Zhongliang Duan, Chunxiang Li, Jing Xu, Chaoming Xia
BACKGROUND: Th1, Th2, Th17, Treg and Tfh cells play important roles in schistosomiasis. Th9 cells secrete IL-9 as a signature cytokine and contribute to several classes of inflammatory disease. However, the effects of Th9 cells in schistosomiasis are unknown. We aimed to explore the dynamic changes and potential roles of Th9 cells in the pathogenesis of hepatic egg granulomatous inflammation in mice infected with Schistosoma japonicum. METHODS: Twenty mice with S...
June 24, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28646622/dormancy-cycles-in-buried-seeds-of-three-perennial-xyris-xyridaceae-species-from-the-brazilian-campo-rupestre
#13
T G S Oliveira, I P Diamantino, Q S Garcia
Seed dormancy cycles are an important mechanism for avoiding germination under unfavorable periods for seedling establishment. This mechanism has been scarcely studied in tropical species. Here, we studied three tropical and perennial species of Xyris, X. asperula, X. subsetigera and X. trachyphylla, to investigate in situ longevity and the existence of seasonal seed dormancy cycles. Seeds of three species of Xyris were buried in their natural habitat with samples exhumed bimonthly for 18 months. Germination of exhumed seeds was assessed under a 12h-photoperiod over a broad range of temperatures...
June 24, 2017: Plant Biology
https://www.readbyqxmd.com/read/28646190/brain-to-brain-entrainment-eeg-interbrain-synchronization-while-speaking-and-listening
#14
Alejandro Pérez, Manuel Carreiras, Jon Andoni Duñabeitia
Electroencephalographic hyperscanning was used to investigate interbrain synchronization patterns in dyads of participants interacting through speech. Results show that brain oscillations are synchronized between listener and speaker during oral narratives. This interpersonal synchronization is mediated in part by a lower-level sensory mechanism of speech-to-brain synchronization, but also by the interactive process that takes place in the situation per se. These results demonstrate the existence of brain-to-brain entrainment which is not merely an epiphenomenon of auditory processing, during listening to one speaker...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28646175/ribosome-rna-profiling-to-quantify-ovarian-development-and-identify-sex-in-fish
#15
Zhi-Gang Shen, Hong Yao, Liang Guo, Xiao-Xia Li, Han-Ping Wang
Terminologies of ovary development, by somewhat subjective describing and naming main changes of oocytes, have been criticized for confusing and inconsistency of terms and classifications, and the incurred consequences impede communication among researchers. In the present work, we developed regression between ovary development and three ribosome RNA (rRNA) indexes, namely 5S rRNA percent, 18S rRNA percent, and 5S-18S rRNA ratio, using close relationship between volume percent of primary growth stage oocytes or gonadosomatic index and rRNA content, demonstrating species-specific quantification of ovary development can be established in species with either synchronous and asynchronous oogenesis...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28645513/atrial-fibrillation-current-therapies
#16
REVIEW
Romain Pariaut
A rate control or a rhythm control strategy can be applied to the management of atrial fibrillation. Rate control of atrial fibrillation consists of decreasing the ventricular response rate by limiting the number of supraventricular impulses that can travel through the atrioventricular node. The goal of decreasing heart rate in dogs with atrial fibrillation is usually achieved with a combination of the calcium channel blocker diltiazem and digoxin. Rhythm control of atrial fibrillation encompasses pharmacologic and nonpharmacologic methods to terminate the arrhythmia and restore sinus rhythm...
June 20, 2017: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/28645269/restricted-posture-in-dentistry-a-kinematic-analysis-of-orthodontists
#17
Daniela Ohlendorf, Christina Erbe, Imke Hauck, Jennifer Nowak, Ingo Hermanns, Dirk Ditchen, Rolf Ellegast, David A Groneberg
BACKGROUND: This study aims at identifying orthodontic activities with the highest frequency of unfavorable/awkward and static postures held over a period of more than 4 s based on kinematic analysis. Moreover, a separate analysis of static postures for orthodontic and non-orthodontic activities serves to evaluate the duration for which these particular postures are assumed. METHODS: In total, 21 (13f/8 m) orthodontists (age: 31.5 ± 3.8 years) participated in this study...
June 23, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28644911/interictal-oscillations-and-focal-epileptic-disorders
#18
Maxime Lévesque, Pariya Salami, Zahra Shiri, Massimo Avoli
Neuronal network oscillations represent a main feature of the brain activity recorded in the EEG under normal and pathological conditions such as epilepsy. Specific oscillations occur between seizures in patients and in animal models of focal epilepsy, and thus they are termed interictal. According to their shape and intrinsic signal frequency, interictal oscillations are classified as spikes and high frequency oscillations (HFOs). Interictal spikes are recorded in the "wideband" EEG signal and consist of large-amplitude events that usually last less than 1 s; HFOs, in contrast, are extracted by amplifying the appropriately filtered EEG signal, and are usually categorized as ripples (80-200 Hz) and fast ripples (250-500 Hz)...
June 23, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28644658/coevolution-of-synchronization-and-cooperation-in-costly-networked-interactions
#19
Alberto Antonioni, Alessio Cardillo
Despite the large number of studies on synchronization, the hypothesis that interactions bear a cost for involved individuals has seldom been considered. The introduction of costly interactions leads, instead, to the formulation of a dichotomous scenario in which an individual may decide to cooperate and pay the cost in order to get synchronized with the rest of the population. Alternatively, the same individual can decide to free ride, without incurring any cost, waiting for others to get synchronized to his or her state...
June 9, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28644151/ecg-based-4d-dose-reconstruction-of-cardiac-arrhythmia-ablation-with-carbon-ion-beams-application-in-a-porcine-model
#20
Daniel Richter, H Immo Lehmann, Anna Eichhorn, Anna M Constantinescu, Robert Kaderka, Matthias Prall, Patrick Lugenbiel, Mitsuru Takami, Dierk Thomas, Christoph Bert, Marco Durante, Douglas L Packer, Christian Graeff
Noninvasive ablation of cardiac arrhythmia by scanned particle radiotherapy is highly promising, but especially challenging due to cardiac and respiratory motion. Irradiations for catheter-free ablation in intact pigs were carried out at the GSI Helmholtz Center in Darmstadt using scanned carbon ions. Here, we present real-time electrocardiogram (ECG) data to estimate time-resolved (4D) delivered dose. For 11 animals, surface ECGs and temporal structure of beam delivery were acquired during irradiation. R waves were automatically detected from surface ECGs...
June 23, 2017: Physics in Medicine and Biology
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