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https://www.readbyqxmd.com/read/29677537/the-rescue-effect-of-mesenchymal-stem-cell-on-sodium-iodate-induced-retinal-pigment-epithelial-cell-death-through-deactivation-of-nf-%C3%AE%C2%BAb-mediated-nlrp3-inflammasome
#1
Xiying Mao, Ting Pan, Han Shen, Huiyu Xi, Songtao Yuan, Qinghuai Liu
Age-related macular degeneration (AMD) is a multifactorial disease resulting in the gradual loss of retinal pigment epithelium (RPE) and the permanent visual damage. Various risk factors, including oxidative stress, form a complex network at the confluence of inflammation. Mesenchymal stem cell (MSC) is a well-studied population of adult stem cell with strong neuroprotective and immunoregulatory properties. Here, we reported the protective effect of MSC on sodium iodate (NaIO3)-triggered RPE degeneration. Sodium iodate (NaIO3)-induced RPE cell death was remarkably reduced when cocultured with MSC...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29677509/beyond-host-defense-emerging-functions-of-the-immune-system-in-regulating-complex-tissue-physiology
#2
REVIEW
Lucille C Rankin, David Artis
The essential roles played by the immune system in the discrimination between self- versus non/altered-self and its integral role in promoting host defense against invading microbes and tumors have been extensively studied for many years. In these contexts, significant advances have been made in defining the molecular and cellular networks that orchestrate cell-cell communication to mediate host defense and pathogen expulsion. Notably, recent studies indicate that in addition to these classical immune functions, cells of the innate and adaptive immune system also sense complex tissue- and environment-derived signals, including those from the nervous system and the diet...
April 19, 2018: Cell
https://www.readbyqxmd.com/read/29677166/in-vitro-identification-of-new-transcriptomic-and-mirnomic-profiles-associated-with-pulmonary-fibrosis-induced-by-high-doses-everolimus-looking-for-new-pathogenetic-markers-and-therapeutic-targets
#3
Simona Granata, Gloria Santoro, Valentina Masola, Paola Tomei, Fabio Sallustio, Paola Pontrelli, Matteo Accetturo, Nadia Antonucci, Pierluigi Carratù, Antonio Lupo, Gianluigi Zaza
The administration of Everolimus (EVE), a mTOR inhibitor used in transplantation and cancer, is often associated with adverse effects including pulmonary fibrosis. Although the underlying mechanism is not fully clarified, this condition could be in part caused by epithelial to mesenchymal transition (EMT) of airway cells. To improve our knowledge, primary bronchial epithelial cells (BE63/3) were treated with EVE (5 and 100 nM) for 24 h. EMT markers (α-SMA, vimentin, fibronectin) were measured by RT-PCR. Transepithelial resistance was measured by Millicell-ERS ohmmeter...
April 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29676994/sbml-level-3-package-multistate-multicomponent-and-multicompartment-species-version-1-release-1
#4
Fengkai Zhang, Martin Meier-Schellersheim
Rule-based modeling is an approach that permits constructing reaction networks based on the specification of rules for molecular interactions and transformations. These rules can encompass details such as the interacting sub-molecular domains (components) and the states such as phosphorylation and binding status of the involved components. Fine-grained spatial information such as the locations of the molecular components relative to a membrane (e.g. whether a modeled molecular domain is embedded into the inner leaflet of the cellular plasma membrane) can also be provided...
April 20, 2018: Journal of Integrative Bioinformatics
https://www.readbyqxmd.com/read/29676773/modeling-and-simulating-networks-of-interdependent-protein-interactions
#5
Bianca K Stöcker, Johannes Köster, Eli Zamir, Sven Rahmann
Protein interactions are fundamental building blocks of biochemical reaction systems underlying cellular functions. The complexity and functionality of these systems emerge not only from the protein interactions themselves but also from the dependencies between these interactions, as generated by allosteric effects or mutual exclusion due to steric hindrance. Therefore, formal models for integrating and utilizing information about interaction dependencies are of high interest. Here, we describe an approach for endowing protein networks with interaction dependencies using propositional logic, thereby obtaining constrained protein interaction networks ("constrained networks")...
April 20, 2018: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/29676527/undergraduate-nursing-assistant-employment-in-aged-care-has-benefits-for-new-graduates
#6
Maricris Algoso, Lucie Ramjan, Leah East, Kath Peters
AIMS: To determine how undergraduate assistant in nursing employment in aged care helps to prepare new graduates for clinical work as a registered nurse. BACKGROUND: The amount and quality of clinical experience afforded by university programs has been the subject of constant debate in the nursing profession. New graduate nurses are often deemed inadequately prepared for clinical practice and so many nursing students seek employment as assistants in nursing whilst studying to increase their clinical experience...
April 20, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29676484/structural-and-metabolic-brain-correlates-of-apathy-in-huntington-s-disease
#7
Saul Martínez-Horta, Jesús Perez-Perez, Frederic Sampedro, Javier Pagonabarraga, Andrea Horta-Barba, Mar Carceller-Sindreu, Beatriz Gomez-Anson, Gloria Andrea Lozano-Martinez, Diego Alfonso Lopez-Mora, Valle Camacho, Alejandro Fernández-León, Ignasi Carrió, Jaime Kulisevsky
BACKGROUND: Apathy is the most prevalent and characteristic neuropsychiatric feature of Huntington's disease. Congruent with the main early pathological changes, apathy is primarily associated with subcortical damage in frontal-striatal circuits. However, little is known about its precise subserving mechanisms and the contribution of regions other than the basal ganglia. OBJECTIVES: We aimed to define the neural correlates of apathy in Huntington's disease based on gray matter volume and PET/CT of 18 F-fluorodeoxyglucose metabolism...
April 20, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29676458/an-optimized-method-to-measure-human-foxp3-regulatory-t-cells-from-multiple-tissue-types-using-mass-cytometry
#8
Nicholas A J Dawson, Avery J Lam, Laura Cook, Romy E Hoeppli, Raewyn Broady, Anne M Pesenacker, Megan K Leving
Mass cytometry has facilitated the discovery of complex immunological networks and immune cell interactions; however, there are limited reports of using this technology to measure expression of intranuclear antigens such as transcription factors. Herein we describe testing of multiple staining methods to detect FOXP3, the lineage-defining transcription factor for regulatory T cells (Tregs), by mass cytometry. A custom paraformaldehyde/saponin-based fixation and permeabilization method was found to be the optimal method for mass cytometry-based Treg detection, yielding the best balance of FOXP3 detection and preserved cell surface marker expression...
April 20, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29676229/viral-induced-oxidative-and-inflammatory-response-in-alzheimer-s-disease-pathogenesis-with-identification-of-potential-drug-candidates-a-systematic-review-using-systems-biology-approach
#9
Puneet Talwar, Renu Gupta, Suman Kushwaha, Rachna Agarwal, Luciano Saso, Shrikant Kukreti, Ritushree Kukreti
Alzheimer's disease (AD) is genetically complex with multifactorial etiology. Here, we aim to identify the potential viral pathogens leading to aberrant inflammatory and oxidative stress response in AD along with potential drug candidates using systems biology approach. We retrieved protein interactions of amyloid precursor protein (APP) and tau protein (MAPT) from NCBI and genes for oxidative stress from NetAge, for inflammation from NetAge and InnateDB databases. Genes implicated in aging were retrieved from GenAge database and two GEO expression datasets...
April 19, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29675976/influence-of-aspartate-moieties-on-the-self-healing-behavior-of-histidine-rich-supramolecular-polymers
#10
Marcel Enke, Lukas Köps, Stefan Zechel, Johannes C Brendel, Jürgen Vitz, Martin D Hager, Ulrich S Schubert
Aspartate incorporated into the protein structure of mussel byssal threads is believed to play an important role, besides the reversible histidine-zinc interactions, in the self-healing behavior of mussel byssal threads. Therefore, copolymers containing both aspartate and histidine moieties are synthesized in order to investigate the influence of aspartate on the complexation of zinc(II) as well as on the self-healing behavior and the mechanical properties of the resulting supramolecular networks. For this purpose, isothermal titration calorimetry measurements of a model aspartate compound as well as of these copolymers are performed and the thermodynamic parameters are utilized for the design of self-healing copolymers...
April 20, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29675960/translating-value-based-health-care-an-experiment-into-healthcare-governance-and-dialogical-accountability
#11
Morten Bonde, Claus Bossen, Peter Danholt
This article analyses an experiment into healthcare governance in Denmark inspired by principles of value-based health care and intended to re-orient the focus of healthcare governance from 'productivity' to 'value for the patient'. The region in charge of the experiment exempted nine hospital departments from activity-based financing and accountability based on diagnosis-related groups, which allegedly incentivised hospitals in 'perverse' and counterproductive ways. Instead, the departments were to develop new indicators from their local practices to support and account for quality and value for the patient...
April 19, 2018: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29675329/decreased-resting-state-brain-signal-complexity-in-patients-with-mild-cognitive-impairment-and-alzheimer-s-disease-a-multiscale-entropy-analysis
#12
Xuanyu Li, Zhaojun Zhu, Weina Zhao, Yu Sun, Dong Wen, Yunyan Xie, Xiangyu Liu, Haijing Niu, Ying Han
Multiscale entropy (MSE) analysis is a novel entropy-based analysis method for quantifying the complexity of dynamic neural signals and physiological systems across multiple temporal scales. This approach may assist in elucidating the pathophysiologic mechanisms of amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD). Using resting-state fNIRS imaging, we recorded spontaneous brain activity from 31 healthy controls (HC), 27 patients with aMCI, and 24 patients with AD. The quantitative analysis of MSE revealed that reduced brain signal complexity in AD patients in several networks, namely, the default, frontoparietal, ventral and dorsal attention networks...
April 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29675215/redox-active-ligand-controlled-selectivity-of-vanadium-oxidation-on-au-100
#13
Christopher D Tempas, Tobias W Morris, David L Wisman, Duy Le, Naseem U Din, Christopher G Williams, Miao Wang, Alexander V Polezhaev, Talat S Rahman, Kenneth G Caulton, Steven L Tait
Metal-organic coordination networks at surfaces, formed by on-surface redox assembly, are of interest for designing specific and selective chemical function at surfaces for heterogeneous catalysts and other applications. The chemical reactivity of single-site transition metals in on-surface coordination networks, which is essential to these applications, has not previously been fully characterized. Here, we demonstrate with a surface-supported, single-site V system that not only are these sites active toward dioxygen activation, but the products of that reaction show much higher selectivity than traditional vanadium nanoparticles, leading to only one V-oxo product...
February 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29675146/efficient-prediction-of-reaction-paths-through-molecular-graph-and-reaction-network-analysis
#14
Yeonjoon Kim, Jin Woo Kim, Zeehyo Kim, Woo Youn Kim
Despite remarkable advances in computational chemistry, prediction of reaction mechanisms is still challenging, because investigating all possible reaction pathways is computationally prohibitive due to the high complexity of chemical space. A feasible strategy for efficient prediction is to utilize chemical heuristics. Here, we propose a novel approach to rapidly search reaction paths in a fully automated fashion by combining chemical theory and heuristics. A key idea of our method is to extract a minimal reaction network composed of only favorable reaction pathways from the complex chemical space through molecular graph and reaction network analysis...
January 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29674565/systematic-analysis-of-complex-genetic-interactions
#15
Elena Kuzmin, Benjamin VanderSluis, Wen Wang, Guihong Tan, Raamesh Deshpande, Yiqun Chen, Matej Usaj, Attila Balint, Mojca Mattiazzi Usaj, Jolanda van Leeuwen, Elizabeth N Koch, Carles Pons, Andrius J Dagilis, Michael Pryszlak, Jason Zi Yang Wang, Julia Hanchard, Margot Riggi, Kaicong Xu, Hamed Heydari, Bryan-Joseph San Luis, Ermira Shuteriqi, Hongwei Zhu, Nydia Van Dyk, Sara Sharifpoor, Michael Costanzo, Robbie Loewith, Amy Caudy, Daniel Bolnick, Grant W Brown, Brenda J Andrews, Charles Boone, Chad L Myers
To systematically explore complex genetic interactions, we constructed ~200,000 yeast triple mutants and scored negative trigenic interactions. We selected double-mutant query genes across a broad spectrum of biological processes, spanning a range of quantitative features of the global digenic interaction network and tested for a genetic interaction with a third mutation. Trigenic interactions often occurred among functionally related genes, and essential genes were hubs on the trigenic network. Despite their functional enrichment, trigenic interactions tended to link genes in distant bioprocesses and displayed a weaker magnitude than digenic interactions...
April 20, 2018: Science
https://www.readbyqxmd.com/read/29674235/deep-embedding-convolutional-neural-network-for-synthesizing-ct-image-from-t1-weighted-mr-image
#16
Lei Xiang, Qian Wang, Dong Nie, Lichi Zhang, Xiyao Jin, Yu Qiao, Dinggang Shen
Recently, more and more attention is drawn to the field of medical image synthesis across modalities. Among them, the synthesis of computed tomography (CT) image from T1-weighted magnetic resonance (MR) image is of great importance, although the mapping between them is highly complex due to large gaps of appearances of the two modalities. In this work, we aim to tackle this MR-to-CT synthesis task by a novel deep embedding convolutional neural network (DECNN). Specifically, we generate the feature maps from MR images, and then transform these feature maps forward through convolutional layers in the network...
March 30, 2018: Medical Image Analysis
https://www.readbyqxmd.com/read/29673968/model-order-effects-on-ica-of-resting-state-complex-valued-fmri-data-application-to-schizophrenia
#17
Li-Dan Kuang, Qiu-Hua Lin, Xiao-Feng Gong, Fengyu Cong, Jing Sui, Vince D Calhoun
BACKGROUND: Component splitting at higher model orders is a widely accepted finding for independent component analysis (ICA) of functional magnetic resonance imaging (fMRI) data. However, our recent study found that intact components occurred with subcomponents at higher model orders. NEW METHOD: This study investigated model order effects on ICA of resting-state complex-valued fMRI data from 82 subjects, which included 40 healthy controls (HCs) and 42 schizophrenia patients...
April 16, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29673936/comparison-between-a-generalized-newtonian-model-and-a-network-type-multiscale-model-for-hemodynamic-behavior-in-the-aortic-arch-validation-with-4d-mri-data-for-a-case-study
#18
Marine Menut, Loïc Boussel, Xavier Escriva, Benyebka Bou-Saïd, Hélène Walter-Le Berre, Yann Marchesse, Antoine Millon, Nellie Della Schiava, Patrick Lermusiaux, John Tichy
Blood is a complex fluid in which the presence of the various constituents leads to significant changes in its rheological properties. Thus, an appropriate non-Newtonian model is advisable; and we choose a Modified version of the rheological model of Phan-Thien and Tanner (MPTT). The different parameters of this model, derived from the rheology of polymers, allow characterization of the non-Newtonian nature of blood, taking into account the behavior of red blood cells in plasma. Using the MPTT model that we implemented in the open access software OpenFOAM, numerical simulations have been performed on blood flow in the thoracic aorta for a healthy patient...
March 29, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29673857/crystalline-silica-alters-sulfatase-1-expression-in-rat-lungs-which-influences-hyper-proliferative-and-fibrogenic-effects-in-human-lung-epithelial-cells
#19
Timothy N Perkins, Paul M Peeters, Catrin Albrecht, Roel P F Schins, Mieke A Dentener, Brooke T Mossman, Emiel F M Wouters, Niki L Reynaert
Lung epithelial cells are the first cell-type to come in contact with hazardous dust materials. Upon deposition, they invoke complex reactions in attempt to eradicate particles from the airways, and repair damage. The cell surface is composed of a heterogeneous network of matrix proteins and proteoglycans, which act as scaffold and control cell-signaling networks. These functions are controlled, in part, by the sulfation patterns of heparin-sulfate proteoglycans (HSPGs), which are enzymatically regulated. Although there is evidence of altered HSPG-sulfation in idiopathic pulmonary fibrosis (IPF), this is not investigated in silicosis...
April 16, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29673346/elements-for-harnessing-participatory-action-research-to-strengthen-health-managers-capacity-a-critical-interpretative-synthesis
#20
REVIEW
Moses Tetui, Joseph Mumba Zulu, Anna-Karin Hurtig, Elizabeth Ekirapa-Kiracho, Suzanne N Kiwanuka, Anna-Britt Coe
BACKGROUND: Health managers play a key role in ensuring that health services are responsive to the needs of the population. Participatory action research (PAR) is one of the approaches that have been used to strengthen managers' capacity. However, collated knowledge on elements for harnessing PAR to strengthen managers' capacity is missing. This paper bridges this gap by reviewing existing literature on the subject matter. METHODS: A critical interpretive synthesis method was used to interrogate eight selected articles...
April 19, 2018: Health Research Policy and Systems
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