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https://www.readbyqxmd.com/read/28426520/nursing-practice-research-and-education-in-the-west-the-best-is-yet-to-come
#1
Heather M Young, Susan Bakewell-Sachs, Linda Sarna
PURPOSE: This paper celebrates the 60th anniversary of the Western Institute of Nursing, the nursing organization representing 13 states in the Western United States, and envisions a preferred future for nursing practice, research, and education. BACKGROUND: Three landmark calls to action contribute to transforming nursing and healthcare: the Patient Protection and Affordable Care Act of 2010; the Institute of Medicine report Future of Nursing: Leading Change, Advancing Health; and the report Advancing Healthcare Transformation: A New Era for Academic Nursing...
April 20, 2017: Nursing Research
https://www.readbyqxmd.com/read/28423132/repair-of-penetrating-pericardial-and-diaphragmatic-injury-with-cormatrix%C3%A2-patch-in-a-case-of-suicide-attempt
#2
Federica Jiritano, Carlo Garrasi, Lucia Cristodoro, Egidio Bevacqua, Pasquale Mastroroberto
The authors report the case of a suicide attempt. A 59-year-old man with self-inflicted penetrating chest trauma underwent emergency cardiothoracic surgery. Pre-operative computed tomography scan showed critical proximity between the blade and the right ventricle. Intraoperative findings showed a pericardial laceration and a huge diaphragmatic lesion with heart and abdominal organs integrity. The diaphragm muscle was repaired with a CorMatrix® patch, an acceptable alternative to the traditional synthetic mesh avoiding infection and repeated herniation...
January 2017: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28422986/a-critical-like-collective-state-leads-to-long-range-cell-communication-in-dictyostelium-discoideum-aggregation
#3
Giovanna De Palo, Darvin Yi, Robert G Endres
The transition from single-cell to multicellular behavior is important in early development but rarely studied. The starvation-induced aggregation of the social amoeba Dictyostelium discoideum into a multicellular slug is known to result from single-cell chemotaxis towards emitted pulses of cyclic adenosine monophosphate (cAMP). However, how exactly do transient, short-range chemical gradients lead to coherent collective movement at a macroscopic scale? Here, we developed a multiscale model verified by quantitative microscopy to describe behaviors ranging widely from chemotaxis and excitability of individual cells to aggregation of thousands of cells...
April 2017: PLoS Biology
https://www.readbyqxmd.com/read/28415359/experimental-investigation-of-the-effect-of-thresholding-on-temporal-statistics-of-avalanches
#4
M A Lebyodkin, I V Shashkov, T A Lebedkina, V S Gornakov
Avalanchelike behavior reflected in power-law statistics is a ubiquitous property of extended systems addressed in a number of generic models. The paper presents an experimental investigation of the effect of thresholding on the statistics of durations and waiting times between avalanches using acoustic emission accompanying unstable plastic deformation. It is found that durations of acoustic events obey power-law statistical distributions robust against thresholding. The quiescent time distributions follow the Poisson law for low threshold values...
March 2017: Physical Review. E
https://www.readbyqxmd.com/read/28415342/griffiths-phase-on-hierarchical-modular-networks-with-small-world-edges
#5
Shanshan Li
The Griffiths phase has been proposed to induce a stretched critical regime that facilitates self-organizing of brain networks for optimal function. This phase stems from the intrinsic structural heterogeneity of brain networks, i.e., the hierarchical modular structure. In this work, the Griffiths phase is studied in modified hierarchical networks with small-world connections based on the 3-regular Hanoi network. Through extensive simulations, the hierarchical level-dependent inter-module wiring probabilities are identified to determine the emergence of the Griffiths phase...
March 2017: Physical Review. E
https://www.readbyqxmd.com/read/28415149/integrating-teamstepps-%C3%A2-into-ambulatory-reproductive-health-care-early-successes-and-lessons-learned
#6
Maureen E Paul, Laura E Dodge, Evelyn Intondi, Guzey Ozcelik, Ken Plitt, Michele R Hacker
BACKGROUND: Most medical teamwork improvement interventions have occurred in hospitals, and more efforts are needed to integrate them into ambulatory care settings. In 2014, Affiliates Risk Management Services, Inc. (ARMS), the risk management services organization for a large network of reproductive health care organizations in the United States, launched a voluntary 5-year initiative to implement a medical teamwork system in this network using the TeamSTEPPS model. This article describes the ARMS initiative and progress made during the first 2 years, including lessons learned...
April 2017: Journal of Healthcare Risk Management: the Journal of the American Society for Healthcare Risk Management
https://www.readbyqxmd.com/read/28404939/d-tocotrienol-a-natural-form-of-vitamin-e-inhibits-pancreatic-cancer-stem-like-cells-and-prevents-pancreatic-cancer-metastasis
#7
Kazim Husain, Barbara A Centeno, Domenico Coppola, Jose Trevino, Said M Sebti, Mokenge P Malafa
The growth, metastasis, and chemotherapy resistance of pancreatic ductal adenocarcinoma (PDAC) is characterized by the activation and growth of tumor-initiating cells in distant organs that have stem-like properties. Thus, inhibiting growth of these cells may prevent PDAC growth and metastases. We have demonstrated that δ-tocotrienol, a natural form of vitamin E (VEDT), is bioactive against cancer, delays progression, and prevents metastases in transgenic mouse models of PDAC. In this report, we provide the first evidence that VEDT selectively inhibits PDAC stem-like cells...
February 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28404746/wound-induced-ca-2-wave-propagates-through-a-simple-release-and-diffusion-mechanism
#8
L Naomi Handly, Roy Wollman
Damage associated molecular patterns (DAMPs) are critical mediators of information concerning tissue damage from damaged cells to neighboring healthy cells. Adenosine triphosphate (ATP) acts as an effective DAMP when released into extracellular space from damaged cells. Extracellular ATP receptors monitor tissue damage and activate a Ca(2+) wave in the surrounding healthy cells. How the Ca(2+) wave propagates through cells following a wound is unclear. Ca(2+) wave activation can occur extracellularly via external receptors or intracellularly through GAP junctions...
April 12, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28403855/quality-of-life-of-breast-and-cervical-cancer-survivors
#9
Huei-Ying Huang, Wen-Chen Tsai, Wen-Yu Chou, Yao-Ching Hung, Liang-Chih Liu, Kuo-Feng Huang, Wen-Ching Wang, Kam-Wing Leung, Ruey-Kuen Hsieh, Pei-Tseng Kung
BACKGROUND: Breast and cervical cancer are the most common cancers affecting women. The symptom distresses experienced by cancer survivors are critical factors influencing their quality of life (QOL). This study investigated the QOL of breast and cervical cancer survivors, their physical, psychological and social conditions. METHODS: The participants were older than 20 years, had been diagnosed with breast or cervical cancer for more than 2 years, and had completed their cancer treatment...
April 12, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28402942/mesenchymal-stem-cells-and-their-therapeutic-applications-in-inflammatory-bowel-disease
#10
REVIEW
Fei Mao, Qiang Tu, Li Wang, Fuliang Chu, Xia Li, Haiyan S Li, Wenrong Xu
Mesenchymal stem or stromal cells (MSCs) are non-hematopoietic stem cells that facilitate tissue regeneration through mechanisms involving self-renewal and differentiation, supporting angiogenesis and tissue cell survival, and limiting inflammation. MSCs were originally identified and expanded in long-term cultures of cells from bone marrow and other organs; and their native identity was recently confined into pericytes and adventitial cells in vascularized tissue. The multipotency, as well as the trophic and immunosuppressive effects, of MSCs have prompted the rapid development of clinical applications for many diseases involving tissue inflammation and immune disorders, including inflammatory bowel disease...
March 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28383814/specular-and-diffuse-reflectance-of-phase-separated-polymer-blend-films
#11
Asritha Nallapaneni, Matthew D Shawkey, Alamgir Karim
Diffuse reflectors have various applications in devices ranging from liquid crystal displays to light emitting diodes, to coatings. Herein, specular and diffuse reflectance from controlled phase separation of polymer blend films, a well-known self-organization process, are studied. Temperature-induced spinodal phase separation of polymer blend films in which one of the components is selectively extracted is shown to exhibit enhanced surface roughness as compared to unextracted films, leading to a notable increase of diffuse reflectance...
April 6, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28375996/listening-to-how-experienced-nurses-care-for-the-dying-husband-and-his-spouse
#12
Lana McLouth Kanacki, Betty Wehtje Winslow
BACKGROUND: Although most nurses in critical care settings provide nursing care for marital couples when 1 of the partners is dying, this is a relatively new area of research. OBJECTIVE: The aim of this study is to describe the nature of nursing care provided for marital couples in the critical care unit when the husbands were dying. METHOD: A qualitative interpretive description was used to construct this study. Data were collected by conducting semistructured individual interviews with 15 experienced critical care nurses in quiet conference rooms...
May 2017: Dimensions of Critical Care Nursing: DCCN
https://www.readbyqxmd.com/read/28375620/self-association-of-rafoxanide-in-aqueous-media-and-its-application-in-preparing-amorphous-solid-dispersions
#13
Fan Meng, Tongzhou Liu, Elizabeth Schneider, Shehab Alzobaidi, Marco Gil, Feng Zhang
Our primary objective is to characterize the self-association of rafoxanide in alkaline media. The second objective is to illustrate the feasibility of using rafoxanide micellar solution as the feed solution to prepare amorphous solid dispersion via spray drying. Rafoxanide is a poorly water-soluble drug. It is a weak acid, and its poor aqueous solubility is due to its hydrophobicity. The surface-active property of rafoxanide has not been previously reported. It was discovered that the addition of a small percentage of organic solvents is required to elevate the solubility of rafoxanide above the critical micelle concentration to allow for the formation of micelles...
April 4, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28362447/nonadiabatic-dynamics-of-injected-holes-in-conjugated-polymers
#14
Luiz Antonio Ribeiro Junior, Wiliam Ferreira da Cunha
The dynamics of injected holes in short transient times that precede polaron formation is numerically studied in the framework of a tight-binding electron-phonon interacting approach aimed at describing organic one-dimensional lattices. In particular, the direct impact of internal and external factors on the conversion of injected holes into polarons is carefully investigated. The results show that a hole injected at levels lower than the highest occupied molecular orbital forms self-trapped bound structures that can merge spontaneously to form a polaron after, at least, one picosecond...
April 12, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28352218/cinematic-operation-of-the-cerebral-cortex-interpreted-via-critical-transitions-in-self-organized-dynamic-systems
#15
Robert Kozma, Walter J Freeman
Measurements of local field potentials over the cortical surface and the scalp of animals and human subjects reveal intermittent bursts of beta and gamma oscillations. During the bursts, narrow-band metastable amplitude modulation (AM) patters emerge for a fraction of a second and ultimately dissolve to the broad-band random background activity. The burst process depends on previously learnt conditioned stimuli (CS), thus different AM patterns may emerge in response to different CS. This observation leads to our cinematic theory of cognition when perception happens in discrete steps manifested in the sequence of AM patterns...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28351068/what-attitudes-and-values-are-incorporated-into-self-as-part-of-professional-identity-construction-when-becoming-a-surgeon
#16
Alexandra Cope, Jeff Bezemer, Stella Mavroveli, Roger Kneebone
PURPOSE: To make explicit the attitudes and values of a community of surgeons, with the aim of understanding professional identity construction within a specific group of residents. METHOD: Using a grounded theory method, the authors collected data from 16 postgraduate surgeons through interviews. They complemented these initial interview data with ethnographic observations and additional descriptive interviews to explore the attitudes and values learned by surgeons during residency training (2010-2013)...
April 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28350668/regeneration-of-vascularized-corticocancellous-bone-and-diploic-space-using-muscle-derived-stem-cells-a-translational-biologic-alternative-for-healing-critical-bone-defects
#17
Denver Lough, Edward Swanson, Nikolai A Sopko, Christopher Madsen, Devin Miller, Howard Wang, Qiongyu Guo, Srinivas M Sursala, Anand R Kumar
BACKGROUND: Regeneration of functional bone substrate remains a priority in reconstructive surgery especially for patients suffering from complex skeletal defects. Efforts to develop implantable osteoinductive constructs and novel osteoconductive materials remain at the forefront of industry forces and product line development. Despite advancement in clinical practice and bone biology, cancellous autograft remains the gold standard for procedures requiring osteogenic mechanisms of healing...
April 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28341421/mutations-evolution-and-the-central-role-of-a-self-defined-fitness-function-in-the-initiation-and-progression-of-cancer
#18
Robert A Gatenby, Joel Brown
The origin and progression of cancer is widely viewed as "somatic evolution" driven by the accumulation of random genetic changes. This theoretical model, however, neglects fundamental conditions for evolution by natural selection, which include competition for survival and a local environmental context. Recent observations that the mutational burden in different cancers can vary by 2 orders of magnitude and that multiple mutations, some of which are "oncogenic," are observed in normal tissue suggests these neglected Darwinian dynamics may play a critical role in modifying the evolutionary consequences of molecular events...
March 21, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28333497/not-all-nonnormal-distributions-are-created-equal-improved-theoretical-and-measurement-precision
#19
Harry Joo, Herman Aguinis, Kyle J Bradley
We offer a four-category taxonomy of individual output distributions (i.e., distributions of cumulative results): (1) pure power law; (2) lognormal; (3) exponential tail (including exponential and power law with an exponential cutoff); and (4) symmetric or potentially symmetric (including normal, Poisson, and Weibull). The four categories are uniquely associated with mutually exclusive generative mechanisms: self-organized criticality, proportionate differentiation, incremental differentiation, and homogenization...
March 23, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28330829/does-telehealth-monitoring-identify-exacerbations-of-chronic-obstructive-pulmonary-disease-and-reduce-hospitalisations-an-analysis-of-system-data
#20
Melissa Kargiannakis, Deborah A Fitzsimmons, Claire L Bentley, Gail A Mountain
BACKGROUND: The increasing prevalence and associated cost of treating chronic obstructive pulmonary disease (COPD) is unsustainable. Health care organizations are focusing on ways to support self-management and prevent hospital admissions, including telehealth-monitoring services capturing physiological and health status data. This paper reports on data captured during a pilot randomized controlled trial of telehealth-supported care within a community-based service for patients discharged from hospital following an exacerbation of their COPD...
March 22, 2017: JMIR Medical Informatics
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