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Pediatric SIRS

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https://www.readbyqxmd.com/read/28333771/classification-of-acute-pancreatitis-in-the-pediatric-population-clinical-report-from-the-naspghan-pancreas-committee
#1
Maisam Abu-El-Haija, Soma Kumar, Flora Szabo, Steven Werlin, Darwin Conwell, Peter Banks, Veronique D Morinville
INTRODUCTION: Acute pancreatitis (AP) is an emerging problem in pediatrics, with most cases resolving spontaneously. However, approximately 10-30% are believed to develop "severe acute pancreatitis" (SAP). METHODS: This consensus statement on the classification of AP in pediatrics was developed through a working group that performed an evidence-based search for classification of AP in adult pancreatitis, definitions and criteria of Systemic Inflammatory Response Syndrome (SIRS), and organ failure in pediatrics...
March 22, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28265695/pediatric-interventional-radiology-workforce-survey-10-year-follow-up
#2
Claire S Kaufman, Charles A James, Roger K Harned, Bairbre L Connolly, Derek J Roebuck, Anne M Cahill, Josee Dubois, Frank P Morello, Robin K Morgan, Manrita K Sidhu
BACKGROUND: Pediatric interventional radiology is a distinct subspecialty differing from both pediatric diagnostic radiology and adult interventional radiology. We conducted a workforce survey in 2005 to evaluate the state of pediatric interventional radiology at that time. Since then there have been many advancements to the subspecialty, including the founding of the Society for Pediatric Interventional Radiology (SPIR). OBJECTIVE: To evaluate the current state of the pediatric interventional radiology workforce and compare findings with those of the initial 2005 workforce survey...
March 6, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28193515/infliximab-is-not-associated-with-increased-risk-of-malignancy-or-hemophagocytic-lymphohistiocytosis-in-pediatric-patients-with-inflammatory-bowel-disease
#3
Jeffrey S Hyams, Marla C Dubinsky, Robert N Baldassano, Richard B Colletti, Salvatore Cucchiara, Johanna Escher, William Faubion, John Fell, Benjamin D Gold, Anne Griffiths, Sibylle Koletzko, Subra Kugathasan, James Markowitz, Frank M Ruemmele, Gigi Veereman, Harland Winter, Nicholas Masel, Chu Ri Shin, Kezhen L Tang, Meena Thayu
BACKGROUND AND AIMS: Immunosuppressive therapy for inflammatory bowel disease (IBD) in pediatric patients is thought to increase the risk of malignancy and lymphoproliferative disorders, including hemophagocytic lymphohistiocytosis (HLH). We compared unadjusted incidence rates of malignancy and HLH in pediatric patients with IBD exposed to infliximab (IFX) with patients not exposed to biologics and calculated standardized incidence ratios (SIRs). METHODS: We collected and analyzed data from 5766 participants in a prospective study of long-term outcomes of pediatric patients with IBD (NCT00606346), from 2007 through 30 June 2016...
February 11, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28179451/cushing-s-syndrome-in-children-and-adolescents-a-danish-nationwide-population-based-cohort-study
#4
Johanne Marie Holst, Erzsébet Horváth-Puhó, Rikke Beck Jensen, Mariane Rix, Kurt Kristensen, Niels Thomas Hertel, Olaf M Dekkers, Henrik Toft Sørensen, Anders Juul, Jens Otto L Jørgensen
OBJECTIVE: Cushing's syndrome (CS) affects all age groups, but epidemiologic data in young patients are very limited. We therefore examined the incidence, prevalence and hospital morbidity of CS in children and adolescents. DESIGN: In a nationwide cohort study, we included all Danish citizens aged 0-20 years from 1977 to 2012. Data were obtained from the Danish National Patient Registry using the International Classification of Diseases (ICD) codes and the Danish Civil Registration System...
May 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27928843/systemic-inflammatory-response-syndrome-after-pediatric-congenital-heart-surgery-incidence-risk-factors-and-clinical-outcome
#5
Martin Boehne, Michael Sasse, André Karch, Friederike Dziuba, Alexander Horke, Torsten Kaussen, Rafael Mikolajczyk, Philipp Beerbaum, Thomas Jack
BACKGROUND: Systemic inflammatory response syndrome (SIRS) is frequent after cardiac surgery, but data on its incidence and perioperative risk factors are scarce for children with congenital heart disease. METHODS: SIRS incidence within 72 hours following cardiac surgery was evaluated in a secondary analysis of children enrolled to a treatment-free control group of a randomized controlled trial. Intraoperative parameters were investigated for their association with SIRS using multivariable fractional polynomial logistic regression models...
December 7, 2016: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/27807483/a-sizable-aortic-root-paravalvular-mycotic-pseudoaneurysm
#6
Ahmad Saeed Azhar, Noran M Abu-Ouf
Mycotic aneurysm is an established condition first identified in 1885 by Sir William Osler. It is linked to malignant endocarditis. With prevalence of 0.7-2.6% of all cases of aortic aneurysms, it is associated with a significant rate of mortality and morbidity. Physicians should be highly cautious, as diagnosis and effective treatment for this condition are difficult. The following is a case report of a 13-year-old pediatric patient diagnosed with mycotic aneurysm. Before an adequate treatment plan could be developed and implemented, patient's status worsened swiftly and was ultimately terminal...
2016: Case Reports in Cardiology
https://www.readbyqxmd.com/read/27805307/distinguishing-pediatric-and-adolescent-renal-cell-carcinoma-from-other-renal-malignancies
#7
Jamil S Syed, Kevin A Nguyen, Charlotte Q Wu, Nicholas G Cost, Mohummad M Siddiqui, Adam B Hittelman, Brian Shuch
PURPOSE: Renal cell carcinoma (RCC) represents a small proportion of renal malignancies early in life. Distinguishing RCC from other malignancies is important as treatment strategies may differ. We analyze the Surveillance Epidemiology, and End Results (SEER) database to identify predictive factors of RCC in the pediatric population with renal tumors. METHODS: We queried SEER to identify patients from ages 0 to 19 diagnosed with a renal malignancy between 1973 and 2013...
May 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27771157/the-diagnostic-value-of-soluble-urokinase-plasminogen-activator-receptor-supar-compared-to-c-reactive-protein-crp-and-procalcitonin-pct-in-children-with-systemic-inflammatory-response-syndrome-sirs
#8
Melis Şirinoğlu, Ahmet Soysal, Ayşe Karaaslan, Eda Kepenekli Kadayifci, Nilüfer Yalındağ-Öztürk, İsmail Cinel, Ali Yaman, Goncagül Haklar, Önder Şirikci, Serap Turan, Gülşen Altınkanat Gelmez, Güner Söyletir, Mustafa Bakır
BACKGROUND: The aim of the present study was to determine the diagnostic and prognostic values of suPAR and to compare them to CRP and PCT in pediatric patients with systemic inflammatory response syndrome (SIRS). MATERIAL-METHODS: A prospective case-control study was performed.The study was performed in a tertiary university hospital which has a 649-bed capacity. Patients included 27 children with SIRS and 27 control subjects without any infection or immunosuppressive condition...
January 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/27503068/prospective-evaluation-of-septifast-multiplex-pcr-in-children-with-systemic-inflammatory-response-syndrome-under-antibiotic-treatment
#9
Franziska Gies, Eva Tschiedel, Ursula Felderhoff-Müser, Peter-Michael Rath, Joerg Steinmann, Christian Dohna-Schwake
BACKGROUND: Antimicrobially pre-treated children with systemic inflammation often pose a diagnostic challenge to the physician. We aimed to evaluate the additional use of SeptiFast multiplex polymerase chain reaction (PCR) to identify causative pathogens in children with suspected systemic bacterial or fungal infection. METHODS: Prospective observational study in 39 children with systemic inflammatory response syndrome (SIRS) under empiric antibiotic treatment. Primary outcome was the rate of positive blood cultures (BC), compared to the rate of positive SeptiFast (SF) results...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27430754/central-line-associated-bloodstream-infections-in-qu%C3%A3-bec-intensive-care-units-results-from-the-provincial-healthcare-associated-infections-surveillance-program-spin
#10
Lynne Li, Elise Fortin, Claude Tremblay, Muleka Ngenda-Muadi, Caroline Quach
BACKGROUND Following implementation of bundled practices in 2009 in Quebec and Canadian intensive care units (ICUs), we describe CLABSI epidemiology during the last 8 years in the province of Québec (Canada) and compare rates with Canadian and American benchmarks. METHODS CLABSI incidence rates (IRs) and central venous catheter utilization ratios (CVCURs) by year and ICU type were calculated using 2007-2014 data from the Surveillance Provinciale des Infections Nosocomiales (SPIN) program. Using American and Canadian surveillance data, we compared SPIN IRs to rates in other jurisdictions using standardized incidence ratios (SIRs)...
October 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27388690/incidence-of-malignancies-in-patients-with-juvenile-idiopathic-arthritis-a-retrospective-single-center-cohort-study-in-germany
#11
Swaantje Barth, Jenny Schlichtiger, Barbara Hartmann, Betty Bisdorff, Hartmut Michels, Katja Radon, Boris Hügle, Linda Walsh, Johannes-Peter Haas
OBJECTIVES: In recent years, concern has been raised about Juvenile Idiopathic Arthritis (JIA) that it could be associated with an increased risk for malignancies. Therefore, the cancer incidence in the JIA patients was evaluated and compared to the cancer incidence in the German population. METHODS: A retrospective single-center hospital-based cohort study was performed using data on the JIA patients treated between 1952 and 2010 at the German Center for Pediatric and Adolescent Rheumatology (GCPAR) (Garmisch-Partenkirchen, Germany)...
January 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/27273392/long-term-results-of-abi-in-children-with-severe-inner-ear-malformations
#12
Levent Sennaroğlu, Gonca Sennaroğlu, Esra Yücel, Burçak Bilginer, Gamze Atay, M Demir Bajin, Burçe Özgen Mocan, Mehmet Yaral, Filiz Aslan, Betül Çiçek Çnar, Burcu Özkan, Merve Özbal Batuk, Çiğdem Ekin Kirazl, Jale Karakaya, Ahmet Ataş, Sarp Saraç, İbrahim Ziyal
OBJECTIVE: To report the long-term outcomes of children who received auditory brainstem implant (ABI) because of severe inner ear malformations. STUDY DESIGN: Retrospective chart review. SETTING: Tertiary referral otolaryngology clinic. SUBJECTS AND METHODS: Between July 2006 and October 2014, 60 children received ABI at Hacettepe University. Preoperative work up included otolaryngologic examination, audiological assessment, radiological evaluation together with assessment of language development and psychological status...
August 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27147715/a-pragmatic-biomarker-driven-algorithm-to-guide-antibiotic-use-in-the-pediatric-intensive-care-unit-the-optimizing-antibiotic-strategies-in-sepsis-oasis-study
#13
Kevin J Downes, Scott L Weiss, Jeffrey S Gerber, Sarah B Klieger, Julie C Fitzgerald, Fran Balamuth, Sherri E Kubis, Pam Tolomeo, Warren B Bilker, Xiaoyan Han, Irving Nachamkin, Charles Garrigan, Jennifer H Han, Ebbing Lautenbach, Susan E Coffin
BACKGROUND: Biomarkers that identify critically ill children with systemic inflammatory response syndrome (SIRS) at low risk for bacterial infection may help clinicians reduce unnecessary antibiotic use. METHODS: We conducted a prospective cohort study of children with SIRS and suspected infection admitted to a pediatric intensive care unit from January 5, 2012 to March 7, 2014. We enrolled patients upon initiation of new antibiotics (Time 0) and measured a panel of 8 serum biomarkers daily over 72 hours...
May 4, 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/27139386/automated-transformation-of-openehr-data-instances-to-owl
#14
Birger Haarbrandt, Thomas Jack, Michael Marschollek
Standard-based integration and semantic enrichment of clinical data originating from electronic medical records has shown to be critical to enable secondary use. To facilitate the utilization of semantic technologies on clinical data, we introduce a methodology to enable automated transformation of openEHR-based data to Web Ontology Language (OWL) individuals. To test the correctness of the implementation, de-identified data of 229 patients of the pediatric intensive care unit of Hannover Medical School has been transformed into 2...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27116911/diagnostic-value-of-soluble-triggering-receptor-expressed-on-myeloid-cells-in-paediatric-sepsis-a-systematic-review
#15
REVIEW
Giuseppe Pontrelli, Franco De Crescenzo, Roberto Buzzetti, Francesca Calò Carducci, Alessandro Jenkner, Donato Amodio, Maia De Luca, Sara Chiurchiù, Elin Haf Davies, Alessandra Simonetti, Elena Ferretti, Martina Della Corte, Luca Gramatica, Susanna Livadiotti, Paolo Rossi
BACKGROUND: Differential diagnosis between sepsis and non-infectious inflammatory disorders demands improved biomarkers. Soluble Triggering Receptor Expression on Myeloid cells (sTREM-1) is an activating receptor whose role has been studied throughout the last decade. We performed a systematic review to evaluate the accuracy of plasma sTREM-1 levels in the diagnosis of sepsis in children with Systemic Inflammatory Response Syndrome (SIRS). METHODS: A literature search of PubMed, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature (CINAHL) and ISI Web of Knowledge databases was performed using specific search terms...
April 27, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27063755/predictors-of-pediatric-cochlear-implantation-outcomes-in-south-africa
#16
MULTICENTER STUDY
Talita le Roux, Bart Vinck, Iain Butler, Nicolize Cass, Liebie Louw, Leone Nauta, Dani Schlesinger, Maggi Soer, Mashudu Tshifularo, De Wet Swanepoel
OBJECTIVE: To identify and describe predictors of pediatric cochlear implantation outcomes in a South African population. METHODS: A retrospective study of 301 pediatric cochlear implant (CI) recipients from five CI programs was conducted and cross-sectional outcome data were added at the time of data collection. Twenty potential prognostic factors were identified from the retrospective dataset, including demographical, CI, risk and family factors. Multiple regression analyses were performed to identify predictor variables that influence outcomes in terms of auditory performance (CAP scores), speech production (SIR scores), communication mode and educational placement...
May 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/26539945/association-of-systemic-inflammatory-response-syndrome-with-clinical-outcomes-of-pediatric-patients-with-pneumonia
#17
COMPARATIVE STUDY
Steven Barron Frazier, Robert Sepanski, Christopher Mangum, Christine Bovat, Arno Zaritsky, Sandip Godambe
OBJECTIVES: Systemic inflammatory response syndrome (SIRS) may complicate pneumonia. When present, it suggests that the patient's pneumonia is more severe. As such, recognition of SIRS among patients with pneumonia may be helpful in identifying those requiring more careful evaluation. Our objective was to examine the relation between the presence of SIRS and adverse clinical outcomes among children with pneumonia seen in the emergency department (ED). METHODS: A retrospective chart review was performed on children diagnosed as having community-acquired pneumonia who presented to a children's hospital ED during a 3-month period...
November 2015: Southern Medical Journal
https://www.readbyqxmd.com/read/26488559/withdrawn-prophylactic-steroids-for-pediatric-open-heart-surgery
#18
REVIEW
Mahmoud Elbarbary, Wedad H Madani, Suzanne Robertson-Malt
No abstract text is available yet for this article.
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26382056/mannose-binding-lectin-mbl-insufficiency-protects-against-the-development-of-systemic-inflammatory-response-after-pediatric-cardiac-surgery
#19
Izabela Pągowska-Klimek, Anna S Świerzko, Mateusz Michalski, Maciej Moll, Agnieszka Szala-Poździej, Anna Sokołowska, Wojciech R Krajewski, Maciej Cedzyński
We investigated MBL2 and MASP2 genotypes, serum MBL (mannose-binding lectin) levels and activities of its complexes with associated serine proteases (MASP-1, MASP -2), in relation to complications following cardiac surgery in 195 children. The incidence of SIRS was lower in patients carrying MBL2 A/O and O/O genotypes (p=0.024). Children with MBL levels <500ng/ml had a lower risk of SIRS (p=0.014) and fever (p=0.044). Median MBL concentration was higher in patients who developed SIRS (p=0.048) but lower in those with post-operative infections (p=0...
February 2016: Immunobiology
https://www.readbyqxmd.com/read/26380998/recent-rehabilitation-experience-with-pediatric-abi-users
#20
Esra Yücel, Filiz Aslan, Hilal Burcu Özkan, Levent Sennaroğlu
OBJECTIVE: The aim of this study is to describe the rehabilitative outcomes of pediatric auditory brainstem implant (ABI) users in the Department of Otolaryngology in the Hacettepe University. It was a retrospective study, and all patients' files were reviewed. MATERIALS AND METHODS: The data was collected from 41 children who were fitted with ABI between 2005 and 2013. Inclusion criteria for children in our study are profound, congenital bilateral sensory-neural hearing loss with anomalies (such as cochlear, labyrinthine, and cochlear nerve aplasia) and more than one year of auditory experience with ABI...
August 2015: Journal of International Advanced Otology
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