keyword
MENU ▼
Read by QxMD icon Read
search

Pathology review

keyword
https://www.readbyqxmd.com/read/29141381/-inflammatory-myofibroblastic-tumor-of-the-hepatobiliary-pancreatic-system-report-of-three-cases-and-literature-review
#1
D F Hou, X M Bu, Y Su, C Zhao, G Y Wang, M W Yang
Objective: To improve the understanding, diagnosis and treatment of inflammatory myofibroblastic tumor (IMT) of the hepatobiliary pancreatic system through the cases review. Methods: The clinical data of three cases of pathologically-proved IMT of the hepatobiliary pancreatic system was reported and relevant literatures were reviewed. Results: Among three cases of IMT discussed, there consisted of a case of liver, a case of gallbladder and a case of pancreas. The clinical manifestations were nonspecific, and the preoperative diagnosis was difficult...
November 14, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29141372/-role-of-adrenal-vein-sampling-in-differential-diagnosis-of-primary-aldosteronism-subtypes
#2
H Y Li, P Li, S M Shen, X B Zhang, W H Feng, H Huang, W Chen, D L Zhu
Objective: To investigate the role of adrenal vein sampling (AVS) in identifying the subtype of primary aldosteronism (PA). Methods: AVS was performed in 50 patients who were confirmed as PA between September 2010 and September 2016 in Nanjing Drum Tower Hospital. Clinical, biochemical and follow-up data were reviewed retrospectively. Bilaterally simultaneous catheterization without cosyntropin stimulation and contemporaneous cortisol measurement during AVS were used. Selectivity index (SI)≥1.5 suggested that the sample was from the adrenal vein...
November 14, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29141286/ultrasound-features-of-secondary-appendicitis-in-pediatric-patients
#3
Lyo Min Kwon, Kwanseop Lee, Soo Kee Min, Soo Min Ahn, Hong Il Ha, Min-Jeong Kim
Purpose: The purpose of this study was to evaluate the ultrasonographic findings of secondary appendicitis (SA) and to discuss the differential findings compared with primary appendicitis. Methods: In this study, we analyzed the ultrasonographic findings of 94 patients under 15 years old of age treated at our institution from May 2005 to May 2014 who had bowel inflammation and an inflamed appendix with a maximal outer diameter >6 mm that improved with nonsurgical treatment (the SA group)...
August 25, 2017: Ultrasonography
https://www.readbyqxmd.com/read/29141184/unrecognized-venous-injuries-after-cardiac-implantable-electronic-device-transvenous-lead-extraction
#4
Khaldoun G Tarakji, Walid Saliba, Danny Markabawi, E Rene Rodriguez, Yoaav Krauthammer, Michael P Brunner, Ayman A Hussein, Bryan Baranowski, Daniel J Cantillon, Mohamed Kanj, Mark Niebauer, Jack Rickard, Thomas Callahan, Mingyuan Shao, David O Martin, Oussama M Wazni, Bruce L Wilkoff, Carmela D Tan
BACKGROUND: Major complication rate of transvenous lead extraction (TLE) is estimated around 1-2.0%. Laceration of the central veins can be fatal. OBJECTIVES: to define the incidence and extent of venous injuries on a microscopic level after TLE and compare it with the incidence of clinically documented events of venous laceration. METHODS: We studied all patients who underwent TLE at our tertiary center within 30 months via a variety of techniques...
November 7, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29140994/copy-number-gains-at-chr3p25-and-chr11p11-are-associated-with-lymph-node-involvement-and-survival-in-muscle-invasive-bladder-tumors
#5
Karla J Lindquist, Thomas Sanford, Terence W Friedlander, Pamela L Paris, Sima P Porten
Patients with muscle-invasive bladder cancer (MIBC) have poorer prognoses if cancer has metastasized to the lymph nodes. Genomic markers of lymph node involvement (LNI) would be useful for treatment planning, especially if measured at the biopsy stage, but large-scale studies of tumor tissue at any stage are needed to discover robust markers of LNI. We performed a genome-wide query of copy number alterations (CNA) in 237 MIBC surgical tumor specimens from patients in The Cancer Genome Atlas who had radical cystectomy and lymphadenectomy without neoadjuvant treatment...
2017: PloS One
https://www.readbyqxmd.com/read/29140757/new-insights-into-lymphoma-pathogenesis
#6
Kojo S J Elenitoba-Johnson, Megan S Lim
Lymphomas represent clonal proliferations of lymphocytes that are broadly classified based upon their maturity (peripheral or mature versus precursor) and lineage (B cell, T cell, and natural killer cell). Insights into the pathogenetic mechanisms involved in lymphoma impact the classification of lymphoma and have significant implications for the diagnosis and clinical management of patients. Serial scientific and technologic advances over the last 30 years in immunology, cytogenetics, molecular biology, gene expression profiling, mass spectrometry-based proteomics, and, more recently, next-generation sequencing have contributed to greatly enhance our understanding of the pathogenetic mechanisms in lymphoma...
November 15, 2017: Annual Review of Pathology
https://www.readbyqxmd.com/read/29140756/cellular-and-molecular-mechanisms-of-autoimmune-hepatitis
#7
G J Webb, G M Hirschfield, E L Krawitt, M E Gershwin
Autoimmune hepatitis is an uncommon idiopathic syndrome of immunemediated destruction of hepatocytes, typically associated with autoantibodies. The disease etiology is incompletely understood but includes a clear association with human leukocyte antigen (HLA) variants and other non- HLA gene variants, female sex, and the environment. Pathologically, there is a CD4+ T cell-rich lymphocytic inflammatory infiltrate with variable hepatocyte necrosis and subsequent hepatic fibrosis. Attempts to understand pathogenesis are informed by several monogenetic syndromes that may include autoimmune liver injury, by several drug and environmental agents that have been identified as triggers in a minority of cases, by human studies that point toward a central role for CD4+ effector and regulatory T cells, and by animal models of the disease...
November 15, 2017: Annual Review of Pathology
https://www.readbyqxmd.com/read/29140405/the-apoptotic-crypt-abscess-an-underappreciated-histologic-finding-in-gastrointestinal-pathology
#8
Geoffrey Talmon, Tristan Manasek, Ross Miller, David Muirhead, Audrey Lazenby
Objectives: To differentiate apoptotic crypt abscesses (ACAs) from neutrophilic crypt abscesses (NCAs). Methods: Cases with crypt abscesses were classified as containing ACAs, NCAs, or mixed crypt abscesses (MCAs) by H&E staining. Sections were stained with cleaved caspase 3 and myeloperoxidase and recategorized. Results: Fifty-nine cases were reviewed: inflammatory bowel disease (IBD; n = 33), acute cellular rejection (n = 5), graft vs host disease (GVHD; n = 14), cytomegalovirus (n = 5), and drug reaction (n = 2)...
November 11, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29140404/evaluation-of-opportunities-to-improve-hematopathology-diagnosis-for-vietnam-pathologists
#9
Vanessa Dayton, Chi Kim Nguyen, Trinh Thu Van, Nguyen Van Thanh, Ta Van To, Nguyen Phi Hung, Nguyen Ngoc Dung, Danny A Milner
Objectives: We evaluate the need for, feasibility of, and impediments to improving hematopathology diagnoses for cancer hospitals in Vietnam. Methods: Two hematopathologists from the United States visited three major cancer treatment hospitals in Vietnam to workshop a sampling of difficult hematopathology cases. With Vietnamese pathologists, they toured histopathology, immunohistochemistry, and ancillary laboratory facilities. Results: Automated tissue processors and slide staining equipment were documented for each of the three hospitals...
November 11, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29140397/progress-in-the-understanding-of-the-pathology-of-allergic-asthma-and-the-potential-of-fruit-proanthocyanidins-as-modulators-of-airway-inflammation
#10
REVIEW
Sara L Coleman, Odette M Shaw
Allergic asthma is a chronic inflammatory lung disease characterized by sensitization of the airways, and the development of immunoglobulin E antibodies, to benign antigens. The established pathophysiology of asthma includes recurrent lung epithelial inflammation, excessive mucus production, bronchial smooth muscle hyperreactivity, and chronic lung tissue remodeling, resulting in reversible airflow restriction. Immune cells, including eosinophils and the recently characterized type 2 innate lymphoid cells, infiltrate into the lung tissue as part of the inflammatory response in allergic asthma...
November 15, 2017: Food & Function
https://www.readbyqxmd.com/read/29140302/danger-high-voltage-the-role-of-voltage-gated-calcium-channels-in-central-nervous-system-pathology
#11
REVIEW
Andrea Schampel, Stefanie Kuerten
Voltage-gated calcium channels (VGCCs) are widely distributed within the central nervous system (CNS) and presumed to play an important role in the pathophysiology of a broad spectrum of CNS disorders including Alzheimer's and Parkinson's disease as well as multiple sclerosis. Several calcium channel blockers have been in clinical practice for many years so that their toxicity and side effects are well studied. However, these drugs are primarily used for the treatment of cardiovascular diseases and most if not all effects on brain functions are secondary to peripheral effects on blood pressure and circulation...
November 15, 2017: Cells
https://www.readbyqxmd.com/read/29140118/-11-c-choline-pet-ct-for-detection-and-localization-of-parathyroid-adenomas
#12
Ahmad Parvinian, Erica L Martin-Macintosh, Ajit H Goenka, Jolanta M Durski, Brian P Mullan, Brad J Kemp, Geoffrey B Johnson
OBJECTIVE: The purpose of this study is to determine the efficacy of (11)C-choline PET/CT for the detection of parathyroid adenomas by retrospectively reviewing a large patient population. MATERIALS AND METHODS: In this single-institution retrospective study, 7088 (11)C-choline PET/CT scans performed of 2933 men with prostate cancer from January 2005 through February 2016 were evaluated. Patients with suspected parathyroid adenomas were identified through a review of the electronic medical record and relevant imaging...
November 15, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29140093/early-diagnosis-and-treatment-of-asymptomatic-vertical-enamel-and-dentin-cracks
#13
Samer S Alassaad
Asymptomatic vertical enamel and dentin cracks can lead to multiple pathologic consequences ranging from caries to pulpal involvement, periodontal involvement, complete tooth fracture, and tooth loss if intervention is postponed. Early diagnosis, using magnification, tactile examination, transillumination, and dyes, and early restorative and occlusal treatments can be incorporated into daily practice to prevent further crack propagation before asymptomatic cracks become symptomatic and cause further damage to the dentition and surrounding tissues...
November 2017: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/29139613/nipple-sparing-mastectomy-as-treatment-for-patients-with-ductal-carcinoma-in%C3%A2-situ-a-10-year-follow-up-study
#14
Víctor Lago, Vincenzo Maisto, Julia Gimenez-Climent, Jose Vila, Carlos Vazquez, Rafael Estevan
The objective was to determine the 10-year oncological safety of nipple-sparing mastectomy (NSM) in patients diagnosed with ductal carcinoma in situ (DCIS). The use of NSM preserves the nipple-areola complex (NAC). As residual fibroglandular breast tissue can remain behind the spared NAC, its use for patient with breast cancer is controversial. The oncologic outcomes and complication rates after performing NSM compared to other techniques are still under debate and a concern when treating patients with breast cancer...
November 15, 2017: Breast Journal
https://www.readbyqxmd.com/read/29139258/-regulatory-effects-of-traditional-chinese-medicine-on-autophagy-in-myocardial-ischemia-reperfusion-injury
#15
REVIEW
Qing Zheng, Yi-Min Bao
Autophagy is a basic process of eliminating unnecessary or damaged organelles by lysosome to maintain the internal environment homeostasis. Recent studies have revealed that autophagy plays an important role in pathology of myocardial ischemia reperfusion. In the phase of ischemia, moderate autophagy can protect the cells against various stress; but in the phase of reperfusion, excessive autophagy can increase the death of cells. Therefore, the dual role of autophagy in myocardial ischemia reperfusion provides a new therapeutic target for the treatment of heart disease...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29139040/recommendations-for-the-follow-up-care-of-female-breast-cancer-survivors-a-guideline-of-the-spanish-society-of-medical-oncology-seom-spanish-society-of-general-medicine-semergen-spanish-society-for-family-and-community-medicine-semfyc-spanish-society-for-general
#16
A Barnadas, M Algara, O Cordoba, A Casas, M Gonzalez, M Marzo, A Montero, M Muñoz, A Ruiz, F Santolaya, T Fernandez
The increased incidence and decreased mortality of breast cancer have produced an increased number of breast cancer survivors. The type of sequelae and comorbidities that these patients present call for a collaborative follow-up by hospital-based specialized care and primary care. In this document, we present a guideline drafted and agreed among scientific societies whose members care for breast cancer survivors. The purpose of this guideline is to achieve the shared and coordinated follow-up of these patients by specialized care and primary care professionals...
November 14, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29138928/mechanisms-of-drug-binding-to-voltage-gated-sodium-channels
#17
M E O'Leary, M Chahine
Voltage-gated sodium (Na(+)) channels are expressed in virtually all electrically excitable tissues and are essential for muscle contraction and the conduction of impulses within the peripheral and central nervous systems. Genetic disorders that disrupt the function of these channels produce an array of Na(+) channelopathies resulting in neuronal impairment, chronic pain, neuromuscular pathologies, and cardiac arrhythmias. Because of their importance to the conduction of electrical signals, Na(+) channels are the target of a wide variety of local anesthetic, antiarrhythmic, anticonvulsant, and antidepressant drugs...
November 15, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/29138853/role-of-innate-lymphoid-cells-in-obesity-and-metabolic-disease-review
#18
Jirakrit Saetang, Surasak Sangkhathat
The immune system has previously been demonstrated to be associated with the pathophysiological development of metabolic abnormalities. However, the mechanisms linking immunity to metabolic disease remain to be fully elucidated. It has previously been suggested that innate lymphoid cells (ILCs) may be involved in the progression of numerous types of metabolic diseases as these cells act as suppressors and promoters for obesity and associated conditions, and are particularly involved in adipose tissue inflammation, which is a major feature of metabolic imbalance...
November 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29138745/spontaneous-nervous-system-concussion-in-dogs-a-description-of-two-cases-and-a-review-of-terminology-in-veterinary-medicine
#19
Angelo Pasquale Giannuzzi, Antonio De Simone, Mario Ricciardi
In human medicine, central nervous system (CNS) concussion is defined as a transient neurological dysfunction following a traumatic event, without evidence of structural abnormalities of the affected region on advanced diagnostic imaging. Depending on the anatomical region involved, three forms of concussive syndromes are described: brain concussion, spinal concussion and cerebellar concussion. Although major textbooks of veterinary neurology admit the existence of canine brain concussion, spontaneous cases of this pathological condition have not been reported in small animals so far...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/29138671/high-circulating-levels-of-angptl2-beyond-a-clinical-marker-of-systemic-inflammation
#20
REVIEW
Nathalie Thorin-Trescases, Eric Thorin
Angiopoietin-like 2 (ANGPTL2) is a proinflammatory protein belonging to the angiopoietin-like family. ANGPTL2 is secreted and detected in the systemic circulation. Different observational clinical studies reported that circulating levels of ANGPTL2 increase significantly in various chronic inflammatory diseases and showed associations between ANGPTL2 levels and diagnosis and/or prognosis of cardiovascular diseases, diabetes, chronic kidney disease, and various types of cancers. However, these studies did not address the following questions: (a) what are the sources of circulating ANGPTL2? (b) How and by which mechanisms an increase in circulating ANGPTL2 contributes to the pathogenesis of chronic inflammatory diseases? (c) Does an increase in circulating levels of ANGPTL2 measured in a well-defined chronic medical condition originate from a specific cell type? Mechanistic hypotheses have been proposed based on studies performed in mice and cultured cells, and proinflammatory, prooxidative, proangiogenic, proliferative, and antiapoptotic properties of ANGPTL2 have been reported...
2017: Oxidative Medicine and Cellular Longevity
keyword
keyword
15498
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"