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Neuromuscular therapy

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https://www.readbyqxmd.com/read/28327054/effects-of-low-frequency-repetitive-transcranial-magnetic-stimulation-and-neuromuscular-electrical-stimulation-on-upper-extremity-motor-recovery-in-the-early-period-after-stroke-a-preliminary-study
#1
Aliye Tosun, Sabiha Türe, Ayhan Askin, Engin Ugur Yardimci, Secil Umit Demirdal, Tülay Kurt Incesu, Ozgur Tosun, Hikmet Kocyigit, Galip Akhan, Fazıl Mustafa Gelal
OBJECTIVE: To assess the efficacy of inhibitory repetitive transcranial magnetic stimulation (rTMS) and neuromuscular electrical stimulation (NMES) on upper extremity motor function in patients with acute/subacute ischemic stroke. METHODS: Twenty-five ischemic acute/subacute stroke subjects were enrolled in this randomized controlled trial. Experimental group 1 received low frequency (LF) rTMS to the primary motor cortex of the unaffected side + physical therapy (PT) including activities to improve strength, flexibility, transfers, posture, balance, coordination, and activities of daily living, mainly focusing on upper limb movements; experimental group 2 received the same protocol combined with NMES to hand extensor muscles; and the control group received only PT...
March 22, 2017: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/28323670/prevention-of-respiratory-complications-of-the-surgical-patient-actionable-plan-for-continued-process-improvement
#2
Katarina J Ruscic, Stephanie D Grabitz, Maíra I Rudolph, Matthias Eikermann
PURPOSE OF REVIEW: Postoperative respiratory complications (PRCs) increase hospitalization time, 30-day mortality and costs by up to $35 000. These outcomes measures have gained prominence as bundled payments have become more common. RECENT FINDINGS: Results of recent quantitative effectiveness studies and clinical trials provide a framework that helps develop center-specific treatment guidelines, tailored to minimize the risk of PRCs. The implementation of those protocols should be guided by a local, respected, and visible facilitator who leads proper implementation while inviting center-specific input from surgeons, anesthesiologists, and other perioperative stakeholders...
March 20, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28302142/maximum-inspiratory-pressure-as-a-clinically-meaningful-trial-endpoint-for-neuromuscular-diseases-a-comprehensive-review-of-the-literature
#3
REVIEW
Benedikt Schoser, Edward Fong, Tarekegn Geberhiwot, Derralynn Hughes, John T Kissel, Shyam C Madathil, David Orlikowski, Michael I Polkey, Mark Roberts, Harm A W M Tiddens, Peter Young
Respiratory muscle strength is a proven predictor of long-term outcome of neuromuscular disease (NMD), including amyotrophic lateral sclerosis, Duchenne muscular dystrophy, and spinal muscular atrophy. Maximal inspiratory pressure (MIP), a sensitive measure of respiratory muscle strength, one of several useful tests of respiratory muscle strength, is gaining interest as a therapeutic clinical trial endpoint for NMD. In this comprehensive review we investigate the use of MIP as a measure of respiratory muscle strength in clinical trials of therapeutics targeting respiratory muscle, examine the correlation of MIP with survival, quality of life, and other measures of pulmonary function, and outline the role of MIP as a clinically significantly meaningful outcome measure...
March 16, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28297684/physical-and-occupational-therapy-utilization-in-a-pediatric-intensive-care-unit
#4
Liang R Cui, Megan LaPorte, Matthew Civitello, Meg Stanger, Maxine Orringer, Frank Casey, Bradley A Kuch, Sue R Beers, Cynthia A Valenta, Patrick M Kochanek, Amy J Houtrow, Ericka L Fink
PURPOSE: To characterize the use of physical therapy (PT) and occupational therapy (OT) consultation in our pediatric intensive care unit (PICU). MATERIALS AND METHODS: We studied children aged 1week-18years admitted to a tertiary care PICU for ≥3days. Patient characteristics, details of PT and OT sessions and adverse events were collected. A multivariable logistic regression was performed to determine factors associated with receipt of PT and OT consultation with propensity analysis followed by a regression for factors associated with outcome...
March 7, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28269315/cortical-excitability-effects-of-stimulation-intensity-change-speed-during-nmes
#5
Shenglong Jiang, Zhongpeng Wang, Weibo Yi, Feng He, Shuang Liu, Hongzhi Qi, Dong Ming
Rehabilitation method of motor dysfunction is a challenging issue of neural rehabilitation. Neuromuscular electrical stimulation (NMES) has been frequently used in rehabilitation therapy to improve neural recovery such as stroke and spinal cord injury. Stimulus, acting on sensorimotor neural system components, resulted in the increased cortical excitability which accompanied with motor performance improvement. Stimulus information conveyed by sensory system included below four elementary attributes: modality, location, intensity, and timing...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268751/model-based-assistance-as-needed-for-robotic-movement-therapy-after-stroke
#6
Hossein Taheri, David J Reinkensmeyer, Eric T Wolbrecht
This paper extends an adaptive control approach for robotic movement therapy that learns deficiencies in a patient's neuromuscular output and assists accordingly. In this method, adaptation is based on trajectory tracking error and a model of unimpaired motor control forces. The controller presented here adaptively learns and fills the gaps in the patient's ability to generate inertial forces, instead of just static forces, as has been proposed before. To test this method, a two dimensional model of an impaired human arm was used to simulate reaching movements in the horizontal plane...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267751/cost-effectiveness-of-adjunct-non-pharmacological-interventions-for-osteoarthritis-of-the-knee
#7
Beth Woods, Andrea Manca, Helen Weatherly, Pedro Saramago, Eleftherios Sideris, Christina Giannopoulou, Stephen Rice, Mark Corbett, Andrew Vickers, Matthew Bowes, Hugh MacPherson, Mark Sculpher
BACKGROUND: There is limited information on the costs and benefits of alternative adjunct non-pharmacological treatments for knee osteoarthritis and little guidance on which should be prioritised for commissioning within the NHS. This study estimates the costs and benefits of acupuncture, braces, heat treatment, insoles, interferential therapy, laser/light therapy, manual therapy, neuromuscular electrical stimulation, pulsed electrical stimulation, pulsed electromagnetic fields, static magnets and transcutaneous electrical nerve Stimulation (TENS), based on all relevant data, to facilitate a more complete assessment of value...
2017: PloS One
https://www.readbyqxmd.com/read/28261743/lllt-actives-mmp-2-and-increases-muscle-mechanical-resistance-after-nerve-sciatic-rat-regeneration
#8
Rodrigo Antonio Carvalho Andraus, Luciana Prado Maia, Anderson Diogo de Souza Lino, Karen Barron Parron Fernandes, Marcos Vinícius de Matos Gomes, Rinaldo Roberto de Jesus Guirro, Cláudio Henrique Barbieri
The purpose of this study was to analyze the low-level laser therapy (LLLT) on metalloproteinase expression and the mechanical strength of skeletal muscle regeneration after peripheral nerve injury. Rats were subjected to crush injury of the right sciatic nerve, followed by LLLT (830 nm, 35, 70, 140, and 280 J/cm(2)) for 21 consecutive days. Functional gait analysis was performed at weekly intervals and the animals were sacrificed after the last evaluation at day 21 for collection of the gastrocnemius muscles, which were submitted to analysis of resistance, and the tibialis anterior, for evaluation of metalloproteinase-2 (MMP-2)...
March 6, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28256693/-communication-and-language-problems-in-children-with-nemaline-myopathy
#9
J F Cervera-Merida, I Villa-Garcia, A Ygual-Fernandez
INTRODUCTION: Nemaline myopathy is a rare disease with an incidence of 1 in every 50,000 live births. It is the most prevalent of the congenital myopathies, a heterogeneous set of neuromuscular disorders present at birth or manifesting at a very early age, which affect the skeletal muscles and give rise to weakness, hypotonia and psychomotor retardation, although cognitive development remains normal. AIM: To review the studies conducted to date on the communication difficulties and dysphagia of children with nemaline myopathy and their possible management based on speech therapy...
February 24, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28251916/genetic-heterogeneity-of-motor-neuropathies
#10
Boglarka Bansagi, Helen Griffin, Roger G Whittaker, Thalia Antoniadi, Teresinha Evangelista, James Miller, Mark Greenslade, Natalie Forester, Jennifer Duff, Anna Bradshaw, Stephanie Kleinle, Veronika Boczonadi, Hannah Steele, Venkateswaran Ramesh, Edit Franko, Angela Pyle, Hanns Lochmüller, Patrick F Chinnery, Rita Horvath
OBJECTIVE: To study the prevalence, molecular cause, and clinical presentation of hereditary motor neuropathies in a large cohort of patients from the North of England. METHODS: Detailed neurologic and electrophysiologic assessments and next-generation panel testing or whole exome sequencing were performed in 105 patients with clinical symptoms of distal hereditary motor neuropathy (dHMN, 64 patients), axonal motor neuropathy (motor Charcot-Marie-Tooth disease [CMT2], 16 patients), or complex neurologic disease predominantly affecting the motor nerves (hereditary motor neuropathy plus, 25 patients)...
March 1, 2017: Neurology
https://www.readbyqxmd.com/read/28241031/a-novel-early-onset-phenotype-in-a-zebrafish-model-of-merosin-deficient-congenital-muscular-dystrophy
#11
Sarah J Smith, Jeffrey C Wang, Vandana A Gupta, James J Dowling
Merosin deficient congenital muscular dystrophy (MDC1A) is a severe neuromuscular disorder with onset in infancy that is associated with severe morbidities (particularly wheelchair dependence) and early mortality. It is caused by recessive mutations in the LAMA2 gene that encodes a subunit of the extracellular matrix protein laminin 211. At present, there are no treatments for this disabling disease. The zebrafish has emerged as a powerful model system for the identification of novel therapies. However, drug discovery in the zebrafish is largely dependent on the identification of phenotypes suitable for chemical screening...
2017: PloS One
https://www.readbyqxmd.com/read/28227554/cortical-excitability-effects-of-stimulation-intensity-change-speed-during-nmes
#12
Shenglong Jiang, Zhongpeng Wang, Weibo Yi, Feng He, Shuang Liu, Hongzhi Qi, Dong Ming, Shenglong Jiang, Zhongpeng Wang, Weibo Yi, Feng He, Shuang Liu, Hongzhi Qi, Dong Ming, Shuang Liu, Shenglong Jiang, Zhonapeng Wang, Dong Ming, Feng He, Qi Hongzhi, Weibo Yi
Rehabilitation method of motor dysfunction is a challenging issue of neural rehabilitation. Neuromuscular electrical stimulation (NMES) has been frequently used in rehabilitation therapy to improve neural recovery such as stroke and spinal cord injury. Stimulus, acting on sensorimotor neural system components, resulted in the increased cortical excitability which accompanied with motor performance improvement. Stimulus information conveyed by sensory system included below four elementary attributes: modality, location, intensity, and timing...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226939/model-based-assistance-as-needed-for-robotic-movement-therapy-after-stroke
#13
Hossein Taheri, David J Reinkensmeyer, Eric T Wolbrecht, Hossein Taheri, David J Reinkensmeyer, Eric T Wolbrecht, Eric T Wolbrecht, David J Reinkensmeyer, Hosoein Taheri
This paper extends an adaptive control approach for robotic movement therapy that learns deficiencies in a patient's neuromuscular output and assists accordingly. In this method, adaptation is based on trajectory tracking error and a model of unimpaired motor control forces. The controller presented here adaptively learns and fills the gaps in the patient's ability to generate inertial forces, instead of just static forces, as has been proposed before. To test this method, a two dimensional model of an impaired human arm was used to simulate reaching movements in the horizontal plane...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28213588/a-differential-autophagy-dependent-response-to-dna-double-strand-brakes-in-bone-marrow-mesenchymal-stem-cells-from-sporadic-als-patients
#14
Shane Wald-Altman, Edward Pichinuk, Or Kakhlon, Miguel Weil
Amyotrophic Lateral Sclerosis (ALS) is an incurable motor neurodegenerative disease caused by a diversity of genetic and environmental factors leading to neuromuscular degeneration and pathophysiological implications in non-neural systems. Our previous work showed abnormal transcriptional expression levels of biomarker genes in non-neuronal cell samples from ALS patients. The same genes proved to be differentially expressed in brain, spinal cord and muscle of the SOD1(G93A) ALS mouse model. These observations support the pathophysiological relevance of the ALS biomarkers discovered in human mesenchymal stem cells (hMSC) isolated from bone marrow samples of ALS patients (ALS-hMSC)...
February 16, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28212216/in-response-effective-doses-of-neuromuscular-blockers-during-electroconvulsive-therapy-and-the-effect-of-ect-parameters
#15
Hooman Mirzakhani, Matthias Eikermann, Edward Bittner, Ala Nozari
No abstract text is available yet for this article.
February 16, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28212212/neuromuscular-blocking-agents-during-electroconvulsive-therapy-was-the-crossover-design-appropriate-and-valid
#16
Mahmoud Daoud
No abstract text is available yet for this article.
April 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28210905/hypermagnesemia-disturbances-in-rats-no-related-pentadecapeptide-bpc-157-abrogates-l-name-and-l-arginine-worsen
#17
Maria Medvidovic-Grubisic, Vasilije Stambolija, Danijela Kolenc, Jadranka Katancic, Tamara Murselovic, Ivna Plestina-Borjan, Sanja Strbe, Domagoj Drmic, Ivan Barisic, Aleksandra Sindic, Sven Seiwerth, Predrag Sikiric
AIM: Stable gastric pentadecapeptide BPC 157, administered before a high-dose magnesium injection in rats, might be a useful peptide therapy against magnesium toxicity and the magnesium-induced effect on cell depolarization. Moreover, this might be an NO-system-related effect. Previously, BPC 157 counteracts paralysis, arrhythmias and hyperkalaemia, extreme muscle weakness; parasympathetic and neuromuscular blockade; injured muscle healing and interacts with the NOS-blocker and NOS-substrate effects...
February 16, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28210859/effectiveness-of-peloid-therapy-in-carpal-tunnel-syndrome-a-randomized-controlled-single-blind-study
#18
Burcu Metin Ökmen, Meliha Kasapoğlu Aksoy, Aygül Güneş, Riza Eröksüz, Lale Altan
Carpal tunnel syndrome(CTS) is the most common neuromuscular cause of upper extremity disability. We aimed to investigate the effectiveness of peloid therapy in patients with CTS. This randomized, controlled, single-blind study enrolled 70 patients between the ages of 30 to 65 who had a diagnosis of either mild, mild-to-moderate, or moderate CTS. The patients were randomized into two groups using random number table. In the first group, (Group 1)(n = 35), patients were given splint (every night for 6 weeks) + peloid treatment(five consecutive days a week for 2 weeks) and in the second group, (Group 2)(n = 28), patients received splint treatment(every night for 6 weeks) alone...
February 16, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28210049/the-immediate-effect-of-neuromuscular-joint-facilitation-on-the-rotation-of-the-tibia-during-walking
#19
Desheng Li, Qiuchen Huang, Ming Huo, Yukinobu Hiiragi, Hitoshi Maruyama
[Purpose] The aim of this study was to investigate the change in tibial rotation during walking among young adults after neuromuscular joint facilitation therapy. [Subjects and Methods] The subjects were twelve healthy young people (6 males, 6 females). A neuromuscular joint facilitation intervention and nonintervention were performed. The interventions were performed one after the other, separated by a 1-week interval. The order of the interventions was completely randomized. The rotation of the tibia during walking was evaluated before and after treatment...
January 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28209529/menopausal-hormone-therapy-is-associated-with-increased-risk-of-fecal-incontinence-in-women-after-menopause
#20
Kyle Staller, Mary K Townsend, Hamed Khalili, Raaj Mehta, Francine Grodstein, William E Whitehead, Catherine A Matthews, Braden Kuo, Andrew T Chan
BACKGROUND & AIMS: Low estrogen levels could contribute to development of fecal incontinence (FI) in women after menopause by altering neuromuscular continence mechanisms. However, studies have produced conflicting results on the association between menopausal hormone therapy (MHT) and risk of FI. METHODS: We studied the association between MHT and risk of FI among 55,828 post-menopausal women (mean age 73 years) who participated in the Nurses' Health Study, enrolled since 2008, with no report of FI...
February 13, 2017: Gastroenterology
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